Climb for a Cure
to global standard
In February 2026, a dedicated team of climbers will take on the Avenue of the Volcanoes Challenge in Ecuador to raise vital funds for the iCMLf. Want to take part or support the cause? Visit www.climb-for-a-cure.raiselysite.com to sign up or donate children with CML globally
In 1998, the world saw the first clinical trials of imatinib - an innovation that changed everything. Today, TKIs have turned CML into a manageable condition. We’re celebrating 25 years of progress with a global timeline of milestones and a special interview with Dr. Brian Druker, who helped lead this revolutionary breakthrough. Read more:
Read more:
iCMLf Global Alliances Update
The iCMLf Genomics and TFR Alliances now bring together over 40 collaborators across 21 countries, working with the HARMONY platform to advance TKI discontinuation and genomic risk prediction.
Genomics Alliance: All sites have now completed data upload, with 9 sites fully finalised and 3 more completing final mapping.
✔ 1,148 cases ready for analysis, with around 300 still to come.
TFR Alliance: 19 sites across 14 countries are participating in the iCMLf/HARMONY TFR project.
✔ 8 sites finalised, 2 mapping, 6 awaiting mapping, and 3 preparing data.
✔ 1,198 cases available for analysis, with around 1,400 more expected.
✔ Data analysis will begin in Q3 2025.
We thank Incyte and Pfizer for supporting the iCMLf Genomics and TFR Alliances.
Quarterly CML Paper Summaries
The iCMLf’s quarterly CML Paper Summaries, curated by Professor Tim Hughes, offer concise overviews of recent research to keep you up to
Recent summaries include:
The e13a3 (b2a3) and e14a3 (b3a3) BCR::ABL1 isoforms are resistant to asciminib High-throughput drug screening identifies SMAC mimetics as enhancers of NK cell cytotoxicity in chronic myeloid leukemia
Read the full summaries:
Congratulations to the 2025 iCMLf Prize Winners
Each year, we honor global leaders shaping the future of CML care:
Rowley Prize: Prof. Satu Mustjoki (Finland): For contributions to CML immunology and biology
Goldman Prize: Dr. Delphine Rea (France): For excellence in clinical leadership and care
iCMLf Prize: Prof. Nicholas Othieno-Abinya (Kenya): For advancing treatment in lowresource settings
Awards will be presented at the ESH-iCMLf 27th Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy.
Regional Discussion Groups 2025: What’s New?
Our RDG series continues to connect clinicians worldwide for timely, regional CML conversations.
Recent highlights:
South Asia: Managing TKI toxicity and third-line options
Latin America: Early molecular response + treatment switching Africa: Innovations in testing and care pathways
View the recordings:
