This paper explores policies, strategies and domestic factors that jointly determine China’s participation in multilateral and regional trade regimes, based on an examination of the performance and roles China played in both the World Trade Organization and some of the regional trade agreement (RTA) negotiations since 2001. China’s attitude and response to the Transatlantic Trade and Investment Partnership negotiations is a case in point that reflects its strategies, policies and domestic factors in RTAs and global trade governance. The case of China’s negotiation in the Regional Comprehensive Economic Partnership represents another.