ALSPAC_GW4_MH_2024

Nic Timpson

ALSPAC / “Children of the 90s”

>30k participants, >1.2million bio-samples, >92k variables, >30 years of deep longitudinal study, ~1,000 researchers, >3000 papers (>200/yr with a virtual h-index of >160)

>20 proposals/month for data/samples

>14541 pregnancies, 75% of all

Linkage consented and >8000 active

>9k at 8yrs, >6k at 18yr, 4.5k stable

>80% linked and >6000 active

G1partners

G0fathers

Grand parents

G0mothers

G1

>2000 new pregnancies

3100 pregnancies over next 5 years

Linkage consented

(Eldest G2 already >15

G3 likely over the next 5 years)

G3

G2

sibling(s)

https://www.bristol.ac.uk/primaryhealthcare/researchthemes/yarah-study/about-the-study/

Herbert, A et al. Categories of Intimate Partner Violence andAbuse Among Young Women and Men: Latent Class Analysis of Psychological, Physical, and Sexual Victimization and Perpetration in a UK Birth Cohort. Journal of Interpersonal Violence (2023) https://doi.org/10.1177/08862605221087708

Trajectories of health

Polygenic health predictors Early events Rare and functional mutations

Rebecca Pearson

Professor of Psychiatric Epidemiology

Manchester Metropolitan University r.pearson@mmu.ac.uk

Alex Kwong

Wellcome Senior Research Fellow

University of Edinburgh akwong@exseed.ed.ac.uk

Kate Northstone (ED Data – ALSPAC)

Professor of Epidemiology and Medical Statistics

University of Bristol kate.northstone@bristol.ac.uk

ALSPAC and mental health over the years

Symptoms of depression not more common after childbirth. Focus needed on understanding antenatal depression.

Era specific comparison allowed by longitudinal followup

EPDS item

Exposure toANTD and PNTD is strongly associated with greater offspring trajectories of depressive symptoms

Netsi et al JAMA Psychiatry (2018)

Weissman – Editorial – JAMA Psychiatry (2018)

ALSPAC and mental health over the years

Averaged population trajectories for males and females.

● Male age of peak velocity of depressive symptoms.

▲ Male age of maximum depressive symptoms.

Female age of peak velocity of depressive symptoms.

■ Female age of maximum depressive symptoms

Common genetic variation (indexed by varying psychiatric PRS) associated with both the severity and rate of change in depressive symptoms throughout adolescence and then into young adulthood

ALSPAC and mental health over the years

Mental health (MH) during COVID-19

Clear age gradients emerging across MH measures in both Generation Scotland and ALSPAC data from Q1

Depression, anxiety worse in in younger populations (ALSPAC-G0: n=3720; ALSPAC-G1: n=2850; GS: n= 4233)

Depression measured by the Short Mood and Feelings Q in ALSPAC and Patient Health Questionnaire 9 in GS

Anxiety measured by the Generalised Anxiety Disorder Assessment in ALSPAC and GS

Kwong et al. Mental health during the COVID-19 pandemic in two longitudinal UK population cohorts. Medrxiv.

Kwong et al. Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts. BJP (2021) doi:10.1192/bjp.2020.242

…@30 data collection – complete and being prepared for use

…New generation data collection bring planned and can be contributed to

…Administrative data linkages – updated and accessible (e.g. GW4 secure data environment)

…New approaches to visualization and access

ALSPAC – finding us and using the resource/platform

How deep is the resource?

Would ALSPAC work for my research?

Cohort profile papers:

Boyd,A. et al. Int J Epidemiol (2013) doi:10.1093/ije/dys064

Fraser,A. et al. Int J Epidemiol (2012) doi:10.1093/ije/dys066.

Lawlor, D.A. et al. Wellcome Open Res (2019) doi:10.12688/wellcomeopenres.15087.2

Northstone, K. et al. Wellcome Open Res (2019) doi:10.12688/wellcomeopenres.15132.1

Major-Smith, D. et al. Wellcome Open Res (2022) doi:10.12688/wellcomeopenres.18564.1

Northstone, K. et al. Wellcome Open Res (2023) doi:10.12688/wellcomeopenres.18782.1

Discoverability

Extensive web material including test data sets (www.bristol.ac.uk/alspac)

Wellcome Open Research (https://wellcomeopenresearch.org/gateways/ALSPAC)

CLOSER (https://closer.ac.uk)

UK Tissue Directory (https://biobankinguk.org)

Dementias Platform UK (https://portal.dementiasplatform.uk)

Birthcohorts.net (www.birthcohorts.net)

Health Data Research UK Innovation Gateway (www.healthdatagateway.org/)

The University of Bristol library – which supports theALSPAC archive (www.bristol.ac.uk/library/specialcollections/strengths/alspac/)

(ALSPAC data are also available and/or advertised through Maelstrom Research www.maelstromresearch.org/study/Alspac, UK Data Service - social science “sampler” https://beta.ukdataservice.ac.uk, the MRC

Cohort Directory and through a series of third parties www.bristol.ac.uk/alspac/researchers/our-data/external-sources/)