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Lorazepam is FDA-approved for the short-term relief of anxiety symptoms associated with distress and anxiety, such as anti-anxiety insomnia. It is also used as a premedication for anaesthesia in adults to relieve anxiety or induce sedation/amnesia and to treat epilepsy. Some off-label lorazepam indications include rapid calming of an agitated patient, alcohol withdrawal delirium, alcohol withdrawal syndrome, muscle spasms, insomnia, panic disorder, delirium, anticipatory nausea and vomiting associated with chemotherapy, and psychogenic catatonia. You can buy Lorazepam online. MECHANISM OF ACTION OF LORAZEPAM: In the postsynaptic GABA-A ligand-gated chloride channel, Lorazepam binds on the benzodiazepine receptor at various places of the central nervous system