Women's Health & Wellbeing

Women’s Health & Wellbeing

From field to supplement, Robertet offers a complete range of natural solutions that cater to women’s needs

Women’s Health & Wellbeing TO A MORE HOLISTIC WELLNESS-ORIENTED APPROACH

P.1

ROBERTET: STRONG EXPERTISE, HIGH QUALITY

P.3

MENOBELLE™ : LIVING THROUGH THE MENOPAUSE COMFORTABLY

P.5

LIPOWHEAT™: FOR HEALTHY, GLOWING SKIN

P.7

AN OUTSTANDING ANTIOXIDANT

P.9

HOLIMEL®: PHOTOAGING PROTECTION

P.11

DIMPLESS®: VISIBLE CELLULITE REDUCTION

P.12

KERANAT™: HAIR BEAUTY SOLUTION

P.13

TAILOR-MADE SOLUTIONS

P.14

TO A MORE HOLISTIC WELLNESS-ORIENTED APPROACH The women’s health and beauty supplements market refers to the segment of the industry that focuses on dietary supplements designed specifically for women to support their health and enhance their beauty.

These supplements are often marketed as supporting healthy aging, promoting radiant skin, boosting energy levels, and addressing specific women’s health concerns such as reproductive, digestive and bone health.

This market has been growing steadily, driven by factors such as increasing awareness about the importance of self-care, rising disposable incomes, and the desire to maintain a youthful appearance.

Lifting taboo around subjects such as menstrual care, menopausal health and sexual wellness, is accelerating consumer demand for more open and positive conversations but also for more targeted solutions that cater to women’s unique health needs.

Global Women’s Health and Beauty Supplements Market Size, By Application, 2022-2023 (USD Billion)

Beauty Women’s Health

100 90 80 70 60

54.5

57.3

59.9

2022

2023

2024

63.9

67.6

70.7

72.9

2027

2028

76.7

80.2

84.4

89.3

50 40 30 20 10 0 2025

2026

2029

2030

2031

2032

Source: Globenewswire.com

In 2023, 47% of women globally seek products and services uniquely tailored to them.

Source: Euromonitor International’s Voice of the Consumer: Lifestyles Survey fielded in January and February 2023

1

A wide spectrum of need states When it comes to health and wellness, many consumers now value personalization more than they did just a few years ago.

Women’s health is a continuous journey that encompasses multiple areas of care across a woman’s lifecycle from puberty and fertility to menopause and beyond.

Having a healthier-looking appearance and feeling good about it is a beautiful gift that helps to be more confident.

Other solutions can help women in their quest for wellbeing, for instance considering multiple needstate dimensions across the physical, nutritional and emotional spectrum.

As women age, they experience multiple social, psychological, physiological and biological challenges.

From menopausal symptoms to skin and hair beauty concerns, Robertet offers a wide range of natural solutions that cater to women’s needs at various stages of life.

These transitions bring significant changes in nutritional requirements and health and beauty considerations.

Those solutions combine environmental sustainability and a sciencefirst approach.

In today’s busy world, everyone is focusing on well-being and women aim to live long and live strong.

2

ROBERTET: STRONG EXPERTISE, HIGH QUALITY Robertet is a French family-run company founded in 1850 in Grasse with two fundamentals: a sense for excellence and passion for natural products. In 2014, Robertet Health & Beauty was created in order to explore the health and beauty benefits of natural ingredients. To industry supply the nutricosmetic with natural, safe, effective and competitive active ingredients, each step of the process is rigorously performed with quality, transparency and security, from field to consumer.

Innovation is one of our main drivers. Based on our phytochemistry and extraction expertise, our multidisciplinary R&D team carefully selects botanical raw materials.

They work everyday to develop high added value active ingredients with clinical proven efficacy.

Fields where the high quality of our natural ingredients begins. Closely working with local European producers, Robertet is involved to set up sustainable and responsible sourcing, allowing to ensure a strong level of traceability.

3

From raw material to active ingredient

Our production sites meet the highest quality standards on the beauty and health markets. Each batch is rigorously analyzed in our analytical laboratory with our state of the art equipment.

Our green production processes are developed in accordance with the environmental requirements.

Regulatory and quality compliance is fundamental to provide nutricosmetic ingredients with steady safety. The specifications of our ingredients are thought to ease the formulation in food supplements or beauty drinks while complying with the regulation frameworks of different markets.

A range of branded ingredients driven by: Naturally-oriented expertise for 200 years Sourcing and extraction experience High level of innovation Quality and safety In & Out solutions Science

Women's health & wellbeing

13

LIVING THROUGH THE MENOPAUSE COMFORTABLY Menobelle™

Thanks to the combination of Lemon Balm, bergamot and Peony, Menobelle™ relieves menopausal discomfort, including mental and physical well-being (EFSA pending claims ID2085, ID2474, ID2087)

A respectful approach to menopause Thanks to a blend of synergistic mediterranean botanicals, Menobelle™ offers a comprehensive solution for women’s health targeting both physical and mental changes of menopause.

Upcycled, Carrier-free

5

Hormones & phytoestrogens free

>20% Flavanons

>10% Polyphenols

Citrus bergamia

Melissa officinalis L.

Paeonia lactiflora

Vasomotor symptoms Cardio-metabolic disorders

Sleep & Mood Cognitive health Digestion & Bloating

Analgesic & Antispasmodic Menopause

Fruit juice concentrate

Patented green extraction

Root powder

Sourced in Italy

Sourced in Spain

Sourced in France

Randomized, placebo controlled exploratory study

1 EXPLORATORY STUDY

475 MG PER DAY

149 MENOPAUSAL WOMEN

2 MONTHS

Evolution of total menopausal symptom score

placebo

Menobelle™

-40%

-54%

Evolution of level of inconvenience of the symptom

PSYCHOSOCIAL SCORE

SEXUAL SCORE

0

0

-20%

-20%

-40%

-40%

-60%

-54% -55%

-60%

-54% -52%

after 2 months

after 2 months

NIGHT SWEATS 0

With Menobelle™, the total menopausal symptom score was significantly reduced compared to placebo (p<0.05) after 2 months of supplementation;

ENDURANCE 0

-20%

Menobelle™ shows significant effects compared to placebo after 2 months for the total sexual score (p<0.05), total psychosocial score (p<0.05) and endurance (p<0.05).

In addition, night sweats show an improvement trend with 54% for Menobelle™ group vs 36.8% for placebo group.

-20% -40% -40% -60%

-54% -59%

-60%

-54% -54%

-80%

after 2 months

after 2 months

Menobelle™

Placebo

$p<0.1 *p<0.05

Women’s health & wellbeing

6

FOR HEALTHY AND GLOWING SKIN PHYTOCERAMIDES

Skin hydration Skin radiance Wrinkle reduction

More than 20 years of research 6 clinical studies 4 publications

Biomimetic phytoceramides complex

LipowheatTM is a 100% plant-based and gluten free ingredient coming from wheat which grows in responsible, organic and sustainable farms.

The wheat comes from European fields of partner producers guaranteeing the highest quality of GMO-free raw material, carefully selected to consistently deliver a high concentrations of lipids, especially phytoceramides.

7

Acting as an inhibitor of collagenase and elastase activity, and boosting collagen production, LipowheatTM contributes to improve skin structure. An ex-vivo test highlighted the effect of LipowheatTM to restore by 30% the collagen synthesis during the skin aging process, At the dermis level, this results in visible reduction of wrinkles. On the epidermis, LipowheatTM strengthens skin’s barrier function and improve skin’s natural hydration levels.

Clinically proven to improve skin appearance

6 CLINICAL STUDIES

350 MG PER DAY

215 WOMEN

HYDRATION & COMFORT POST-SUPPLEMENTATION

Skin hydration (a.u.) measured by Corneometer®

SUPPLEMENTATION

After three months of supplementation, hydration was significantly increased by 29% (p<0.01 significant difference compared to placebo, p<0.05), and by 49% two months after the end of the supplementation.

100% of women noticed an improvement in their itching sensation after 12 weeks.

RADIANT COMPLEXION POST-SUPPLEMENTATION

Skin roughness score measured by dermatologist

SUPPLEMENTATION

Skin radiance score assessed by dermatologist was significantly improved by 24% after 8 weeks (p<0.001) and increased by 33% after 12 weeks versus placebo (p<0.001).

3/4 of women noticed an improved skin glow and complexion after supplementation.

WRINKLES & FINE LINES POST-SUPPLEMENTATION

Lemperle score (a.u.)measured by photonumeric scale

SUPPLEMENTATION

LipowheatTM

After 8 weeks, visible significant results on wrinkles are observed. After 12 weeks of supplementation, the wrinkle score is significantly improved by 29% (p<0.001; significant difference compared to placebo, p<0.001) with a long lasting effect.

72% of women self-assessed the efficacy of Lipowheat™ on wrinkle reduction after 12 weeks.

Placebo

Boisnic S. et al, 2019, Journal of Cosmetic Dermatology Lipowheat.com Women's health & wellbeing

8

AN OUTSTANDING ANTIOXIDANT Holimel

®

Dimpless

®

In & Out efficacy Quick efficacy Low dosage

30 years of research 8 clinical trials 30 publications

SOD coming from a unique variety of melon Holimel® and Dimpless® are natural melon juice concentrates obtained from a proprietary and non-GMO variety of Cantaloupe melon, produced in t h e South of France. The original discovery of this ingredient comes from French melon producers surprised by the impressively long shelf life of this variety.

R&D investigations revealed the very high content of Superoxide Dismutase (SOD), a powerful antioxidant, in the Cantaloupe melon explaining its high longevity.

Patented eco-process Unique and non-GMO variety of Cantaloupe melon Natural process Solvent-free Patented coating

1 SELECTION SORTING WASHING

9

2 SKIN & SEEDS SEPARATION

Thanks to a patented and gentle eco-process using no solvent, ® ® benefit from Holimel and Dimpless a very high content of SOD, an essential antioxidant enzyme, and melon nutrients such as vitamins, minerals, proteins and fibers. For oral application, a patented microencapsulation technology allows to prevent the enzyme from gastric denaturation and ensures its bioactivity. A full range of coating has been developed to answer the specific needs of various applications.

3 GRINDING CENTRIFUGATION FILTRATION

4 CONCENTRATION

5 FREEZE DRYING

6 COATING

Restoring a balanced oxidative status Oxidative stress has been widely studied and is known to be responsible for multiple disorders affecting body organs and tissues and accelerating aging and degeneration of cells. This melon extract acts as a super-antioxidant and has been demonstrated, via topical or oral administration, to boost endogenous expression of primary antioxidant enzymes: SOD, catalase (CAT) and gluthation peroxidase (GPx).

These enzymes exert a powerful antioxidant mechanism of action against free radicals precursor species, and participate to reinforce body defenses and to restore an balanced oxidative status.

At the skin level, Holimel® boosts the endogenous antioxidant defenses and limits the adverse effects induced by UVs on skin.

Thanks to its systemic action, Dimpless® has a multi-parametric effect on fat metabolism. While metabolic disorders may induce adipocyte hypertrophy and fibrosis of t h e c o n n e c t i v e t i s s u e, Dimpless® improves adipose tissue morphology, lipolysis and fibrosis by over 50%.

+14%

+39%

+63%

GPx

CAT

SOD

Effect on antioxidant enzymes s expression, in-vitro test on irradiated human skin explants, compared to untreated explants Women's health & wellbeing

10

PHOTOAGING PROTECTION Holimel

®

Skin resistance to UVs UV-related damage reduction Skin radiance and uniformity

1 CLINICAL STUDY

88 WOMEN

20 MG PER DAY

SKIN RESISTANCE TO UV Combo In & Out

MED (Increase between Do-D33)

MED (Increase between Do-D5)

Change of MED (Minimal Erythema Dose)

Oral administration

MED (Increase between Do-D33)

MED (Increase between Do-D5)

Change of MED (Minimal Erythema Dose)

Topical administration

Holimel® protects the skin from sun exposure damages and delays sunburns by significantly improving skin resistance to UV (p<0.001), in only four days for the cosmetic cream and one month with oral administration.

A synergistic effect is highlighted with the In&Out combination of Holimel®.

SUNBURN PROTECTION

SBC (Number of sunburn cells/mm2)

Holimel® decreases by 72% sunburn cells induced

by UVB exposure on skin explants. Sunburn cells are irreparably damaged and potentially mutagenic keratinocytes.

Holimel®

18

Placebo

Egoumenides L. et al, 2018, Nutrients Holimel.com

VISIBLE CELLULITE REDUCTION Dimpless

®

Cellulite reduction Silhouette improvement Weight management

2 CLINICAL STUDIES

76 WOMEN

40 MG PER DAY

1 TO 3 MONTH

CELLULITE REDUCTION Visual scoring of cellulite (a.u.)

After only one month of supplementation, Dimpless® significantly decreased by 10% the visual scoring of cellulite on tights (p<0.05), while placebo shows no effect.

SUBCUTANEOUS FATS

Change of fold size after 90 days (cm)

After three months of supplementation, Dimpless® significantly reduced gluteal and femoral fold sizes by respectively 23% and 28% compared to the placebo.

WAIST AND HIPS Change of hips and waist size after 90 days (cm)

Dimpless® significantly improved by 46% the waist size and by 40% the hips size compared to placebo after three months of supplementation.

Lemaire B. et al, 2015, Phytothérapie

Dimpless®

Placebo

Dimpless.com Women's health & wellbeing

12

HAIR BEAUTY SOLUTION Hair loss reduction Hair beauty & brightness Scalp dryness improvement

6 years of research 7 pre-clinical & clinical studies 1 international patent

Golden millet, for shining hair KeranatTM takes its origins in the Loire Valley, where millet fields grow in family farms working in sustainable agriculture or organic farming.

The symbol of strength and power, millet has been known for centuries to bring shine to the hair.

Carefully selected, millet seeds hold a very rare molecule, miliacine. KeranatTM miliacine benefits from a patented encapsulation system that enhances its bioavailability.

Due to multiple factors from stress to genetics, hair loss affects up to 50% of women with a high impact on quality of life. In ex-vivo studies, KeranatTM has shown to significantly increase keratinocyte proliferation in hair bulb and IGF-1 excretion, a growth factor secreted by the dermal papilla. On the same study models, the collagen sheath around the hair bulb appeared to be 20% thicker with KeranatTM. These mechanisms contribute to promote a healthy hair growth and to reinforce hair anchorage into the scalp.

13

Clinical results on hair loss and beauty

2 CLINICAL STUDIES

3O0 MG PER DAY

120 WOMEN

HAIR LOSS Hair loss (a.u.) measured by Phototrichogram

Hair loss was significantly reduced by 50% after 12 weeks (p<0.001), with a significant different versus placebo (p<0.05).

91% of women noticed a significant decrease of hair loss

HAIR SHINE AND BEAUTY Brightness and hair beauty assessed by clinical scoring

After 12 weeks of supplementation, brightness and hair beauty score was significantly increased by 2-fold (p<0.001) and significantly improved by 27% versus placebo (p<0.05).

75% of women noticed brighter, softer and more supple hair

SCALP DRYNESS Scalp dryness assessed by clinical scoring

After 6 weeks, the first significant results on scalp dryness were observed.

After 12 weeks of supplementation, the scalp dryness score was significantly decreased by 4-fold (p<0.001), and by 68% versus placebo (p<0.05).

88% of women had a good general impression of the product

Keranat

TM

Placebo

Keophiphath M. et al, 2019, J Cosmet Dermatol.

Keranat.com Women's health & wellbeing

14

TAILOR-MADE SOLUTIONS

A dedicated team At Robertet Health&Beauty, a team of experts is dedicated to answer any questions related to our ingredients, from R&D to business development.

We combine the agility of a human-scale team and the power of an international group.

15

Thanks to our internal ressources and the strength of our wide and qualified network of experts and service providers, we have developed a full-service of tailor-made solutions to support you throughout your nutricosmetic products development.

EA

OM

ID

More than an ingredient supplier

FR

SOURCING

RESEARCH & DEVELOPMENT

LABORATORY ANALYSIS

MARKETING & COMMUNICATION

EFFICACY

SM

REGULATORY & QUALITY

ET IC

PR OD

UC TS

FORMULATION

MANUFACTURERS TO U

N UE Q I N

U

O IC R T

INTERESTED IN OUR INGREDIENTS OR SERVICES ?

Please contact us at: contact@robertet.com Women's health & wellbeing

16

References Boisnic, S., Keophiphath, M., Serandour, A., Branchet, M., Le Breton, S., Lamour, I., & Gaillard, E. (2019). Polar lipids from wheat extract oil improve skin damages induced by aging: Evidence from a randomized, placebo‐ controlled clinical trial in women and an ex vivo study on human skin explant. Journal of Cosmetic Dermatology, 18(6), 2027–2036. https://doi.org/10.1111/jocd.12967

©Robertet - WPWHB0001-1023 – October 2023 - Photo credits @gettyimage @Istock. Creation & design: Irisco ; Production: Pardy. References upon request.

Egoumenides, L., Gauthier, A., Barial, S., Saby, M., Orechenkoff, C., Simoneau, G., & Carillon, J. (2018). A Specific Melon Concentrate Exhibits Photoprotective Effects from Antioxidant Activity in Healthy Adults. Nutrients, 10(4), 437. https://doi.org/10.3390/nu10040437

17

Keophiphath, M., Courbière, C., Manzato, L., Lamour, I., & Gaillard, E. (2020). “Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women”. Journal of Cosmetic Derma-tology, 19(2), 485–493. https://doi.org/10.1111/jocd.12998 Lemaire, B., Le Quéré, S., Simoneau, G., & Lacan, D. (2016). Étude clinique d’une SuperOxide Dismutase de melon naturelle et bioactive (SOD B Dimpless®) sur la cellulite. Phytothérapie, 14(1), 23–28. https://doi.org/10.1007/ s10298-015-0977-4

Robertet.com ROBERTET 400 International Drive, Mount Olive, New Jersey 07828 The information contained herein is for business and information purposes. This information is only shared with professionals. The statements in this document should not be considered as claims under any laws. The products presented should not be considered as drug i.e to diagnose, treat, cure or prevent any disease. Robertet has no liability in the future use of the information presented. Use of any information presented remains under liability of the professional that would use it.

Notes

Women's health & wellbeing

18

Notes

19

Notes

Women's health & wellbeing

18 20

26