C4TS Newsletter www.c4ts.qmul.ac.uk Spring/Summer 2016 Issue 10 Welcome to the C4TS Spring/Summer 2016 newsletter. In this bumper edition, we announce the start of ORDIT, a UK wide study mapping the incidence of multiple organ dysfunction after traumatic injury. Karen Hoffman outlines her plans to establish the UK's first on-line supported self-management program for trauma survivors, and Ross Davenport discusses how a clinical trial to provide the blood product cryoprecipitate early in treating haemorrhaging trauma patients could save more lives. Finally, we report on the resounding success of our Trauma Survivors Day cyclethon - a good omen for our upcoming music festival fundraiser. Enjoy!
Organ Dysfunction in Trauma: ORDIT - a point prevalence study Background Multiple organ dysfunction syndrome (MODS) is an exaggerated systemic inflammatory response following major tissue trauma which results in vital organs suffering temporary or permanent damage. International reports suggest that MODS affects 1 in 3 severely injured patients. However our local trauma data reveals that the burden of MODS may be much higher, with almost 80% of critical care patients being affected. MODS typically develops within a day or two from injury, frequently involving respiratory and coagulation dysfunction. There appears to be two forms of MODS – one that resolves quickly within the early period of critical care or prolonged MODS, which lasts for a week or more, and is associated with high rates of infection, long hospital stays and mortality. Despite advances in initial trauma Centre for Trauma Sciences
Dr Elaine Cole (Principal Investigator ORDIT)
by Dr Elaine Cole (Principal Investigator)
management, with targeted early resuscitation and delivery of care in Major Trauma Centres, little is understood about the incidence, drivers and severity of MODS in the UK trauma population.
ORDIT ORDIT is a one month point prevalence study of all trauma patients admitted to UK Major Trauma Centre (MTC) adult critical care units. It began on 1st June and all UK MTCs are now recruiting patients into the study. The primary aim of the study is to understand how many trauma patients in the UK develop organ dysfunction, how severe it is and at what stage it occurs after their injury. Detailed clinical data is being collected during the patients critical care stay. Other objectives are to evaluate the relationships between MODS and other outcomes such as the rates
Newsletter Spring/Summer 2016
Figure 1 – the Sequential Organ Failure Assessment score is a key ORDIT measurement tool
and mode of mortality. Quality of life data (QoL) at 12 months post injury will also be collected by the C4TS research team.
Implications The study is the first major trauma study to involve all the UK MTCs. It will provide comprehensive baseline data to help us better understand this challenging adverse outcome and contribute to the development of new treatments. More information about ORDIT can be found here. 1