NewsNotes - Summer 2020

CHILDREN’S DIABETES FOUNDATION — SUMMER 2020

NEWSNOTES FEATURES 6

Children’s Diabetes Foundation Board Members EXECUTIVE BOARD: Mrs. Barbara Davis, Chairman Dana Davis, Executive Director

ANTIBODY TESTS

Mr. Cameron van Orman, Vice Chairman Richard S. Abrams, M.D., Treasurer Mrs. Arlene Hirschfeld, Secretary

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Stephen Daniels, M.D., Ph.D. Chairman of Pediatrics The Children’s Hospital, Denver

INSULIN AFFORDABILITY

Mrs. Nancy Davis Rickel Daniel Feiten, M.D.

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40 ANNIVERSARY OF THE BDC TH

Mr. Wayne Forman Mr. Robert Garelick

Mr. Shawn Hunter

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TRIBUTE TO STEVE FARBER

KENDRA SCOTT

Mr. Steve Lucas Mrs. Marcela de la Mar Mrs. Tracy van Orman John J. Reilly, Jr., M.D. Vice Chancellor for Health Affairs & Dean, School of Medicine, University of Colorado Denver Mr. Ken Rickel Mrs. Stacy Mendelson Robinson Marian Rewers, M.D., Ph.D. Ex-Officio Member Mr. Joseph Smolen

Mark Atkinson, Ph.D. Professor of Pathology & Pediatrics, Director, University of Florida Diabetes Institute Ezio Bonifacio, Ph.D. Professor for Preclinical Approaches to Stem Cell Therapy, Center for Regenerative Therapies, Dresden, Germany Robert Eckel, MD Professor of Medicine, Physiology and Biophysics, University of Colorado School of Medicine

Mr. Shane Hendryson Mrs. Deidre Hunter

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SCIENTIFIC ADVISORY BOARD: Richard S. Abrams, M.D. Director, Colorado Preventive Medicine, Rose Medical Center; Clinical Professor of Medicine UCD

Matthias Hebrok, Ph.D. Professor in Residence and Director, Diabetes Center, University of California, San Francisco Steven Kahn, MB, Ch.B. Professor of Medicine, Director of the Diabetes Research Center, University of Washington Rudolph Leibel, MD Professor of Pediatrics and Medicine, Co-Director, Naomi Berrie Diabetes Center, Columbia University Alvin Powers, MD Professor of Medicine, Molecular Physiology/Biophysics, Division Director, Vanderbilt University William Tamborlane, MD Professor of Pediatrics, Yale University School of Medicine

NewsNotes is published quarterly by the Children’s Diabetes Foundation. If you would like to submit an article or a letter to NewsNotes, send information to Brent@ChildrensDiabetesFoundation.org.

Zachary Reece, Graphic Designer Brent McDaniel & Dana Davis, Editors

Facebook.com/ ChildrensDiabetesFoundation

@CDFdiabetes

@CDFdiabetes

CDFcares@ChildrensDiabetesFoundation.org 303-863-1200 • 4380 S. Syracuse St., Ste. 430 Denver, CO 80237

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DANA DAVIS

Executive Director, Children's Diabetes Foundation

Dear Friends, The Children’s Diabetes Foundation, in partnership with the Barbara Davis Center, has served the diabetic community for more than 40 years.

During this time, we have shared in breakthroughs and setbacks along with growth and uncertainty. We have faced every challenge together and built a community that is founded in purpose. This purpose is simple: to support, educate, and care for those with diabetes along with the relentless pursuit for a cure.

Over the past several months, many things have changed: how people work, how people interact, and how they serve their community. Together, the Children’s Diabetes Foundation and the Barbara Davis Center have not only adjusted to the demands of these changes but have embraced the challenge.

Events and gatherings have been cancelled, rescheduled and reimagined.

Patients and their families are utilizing technology to maintain their diabetes while embracing telemedicine as great way to manage their care and build connections with caregivers.

One thing that has not changed is the need to support those affected by diabetes. Patients, families, and caregivers are now, more than ever, in need of support, guidance and advocacy. In fact, the need has greatly expanded!

40% of patients are uninsured or underinsured. 30% are currently at or below the poverty line. These numbers will continue to increase as the year goes on. Diabetes is 24/7. It doesn’t take a break during a pandemic. It cannot be furloughed, and the costs do not go away.

Over the years, we have met the needs of our ever-changing community and our commitment has not changed. Both the Children’s Diabetes Foundation and the Barbara Davis Center are here to serve. This is at the heart of all we do, but the only way we can continue to meet the growing need of our community is with your support.

As our world evolves, people will gather and join together in our amazing community. The challenges we face now may be different than over the past 40 years, but together we will not only survive, we will thrive.

Wishing you and your loved ones continued health and safety today, tomorrow, and always.

LETTER FROM EXECUTIVE DIRECTOR

OUR COMMITMENT TO YOU

P.S. - A special thank you to the members of our community who contributed photos for our cover image. No matter what the world throws at us, these type 1 heroes prove they can handle anything. From creating beautiful sidewalk art to hiking with the family, we can still live happy and healthy lives with type 1 diabetes in spite of the challenges of COVID-19.

(Cover photos, top to bottom, left to right: Jan R. and Bill T., Katie T., Carson C., the Hess family, Izzy C., the Rider family, Dr. Bucca with Rachel and Heidi, Lori F., Christian D., the Fenech family, Samantha B. and friends, Sophie P., the Johnson family, Sharon G., Everly G., Logan M., Valerie W., Aida A., the Corcoran family, Keller S., Jacob R., Lettie, V., the Vande Hoef family, Beckham T., the Iwerson family, the Reinhardt family, the Martin family)

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COVID-19 UPDATE

BDC Clinic and Entry Information Please note: There is mandatory COVID-19 screening for patients and visitors entering the BDC building. Please arrive 5 minutes early to your appointment and use the northwest entrance to the lobby (closest to parking lot).

Pediatric Clinic and Adult Clinic As of May 18, 2020, telemedicine and in-person visits are now available for established patients without recent illness or risk factors. Clinics will be able to see newly diagnosed patients with type 1 diabetes on a limited and scheduled basis. However, we will not be able to see newly diagnosed patients at the BDC if, within the past 14 days, the patient or any member of the household or close contact has had: • •

Fever, cough, respiratory symptoms or shortness of breath Been in close contact (in same room or within 6 feet) with a person diagnosed with or who is under investigation for Coronavirus

Please call 303-724-2323 (Pediatric Clinic) or 303-724-6755 (Adult Clinic) and we will help you to receive diabetes care and education at a safe location.

For established patients, we have expanded our ability to help you without the risk of travel and exposure to Coronavirus.

Our providers are available to schedule visits as telephone or telemedicine visits. To review glucose downloads, make dosing changes, or address non-urgent problems, please contact your provider by MyChart or email between 8 am and 4 pm, Monday through Friday.

Urgent calls: 303-724-2323, press 1 English or 2 for Spanish, then 2 (Peds clinic), and 9 Re-schedule a visit: call 303-724-2323, press 1 English or 2 for Spanish, 2 (Peds clinic), and 2 Prescriptions: call 303-724-2323, press 1 English or 2 for Spanish, 2 (Peds clinic), and 3 (refill) Adult Clinic all calls: 303-724-6755 Eye Clinic As of May 11th, the Eye clinic is open and scheduling in-person visits to those without recent illness or COVID-19 risk factors. Please be advised that there are a reduced number of appointments per day due to University policy. We are gradually increasing the number of appointment slots available as University guidelines permit.

Urgent calls: 303-724-2323 Non-urgent or prescription calls: 720-724-6735 (leave a message) Clinical Research Studies All scheduled in-person visits are cancelled.

If you have a question, please contact your study coordinator/ research assistant. Email might be the best way to contact your study coordinator at this time.

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Colorado’s COVID-19 Resource Guide Find the state’s complete guide online at covid.colorado.gov. This site helps explain current stay-at-home orders and guidelines, connects you with food and employment resources, and provides a full directory of state agencies providing COVID-19 response and recovery assistance.

Prescription Assistance Discount Programs Please visit ChildrensDiabetesFoundation.org/coronavirus for a list of prescription discount programs offered by many pharmaceutical companies.

Colorado Financial Hardship Resources

COVID-19 UPDATE

RESOURCES

Telephone Assistance Program: (303) 866-5700 This is a program that is run in partnership with the Colorado Department of Human Services and it will pay a portion of your monthly phone bill. While some companies may provide a free cell phone, it is more likely to receive a discount on basic phone or cellular service.

Colorado Child Health Plan Plus (CHP+): (800) 359-1991 A low-cost health insurance plan that is offered for Colorado’s uninsured children and pregnant women. It is a health insurance program available for children from low income families and pregnant women who cannot afford private health insurance.

Food Stamps Program: (303) 866-3122 Assists lower income families and individuals who need assistance purchasing food. Helps ensure the nutritional needs of families are met.

Colorado Employment First: (719) 486-2497 Increases employment opportunities for food stamp participants through referrals, support, accountability, and community work, and credit repair. Also provides advice on how to eliminate debt.

Colorado Child Care Assistance Program: (303) 866-5700 This program helps parents afford childcare while they are actively working, receiving job training or looking for work.

This program may also be called the Low-Income Child Care Assistance.

Colorado Works/TANF: (303) 866-6210 This program helps strengthen families by providing cash grants, promoting opportunities for comprehensive job training, and fiscal support to state residents.

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COVID-19 UPDATE

CU ANSCHUTZ SCIENTISTS LAUNCH EFFORT TO BUILD COVID-19 ANTIBODY TEST

By Debra Melani, news.cuanschutz.edu

Putting their heads and labs together, several groups of researchers from across the University of Colorado Anschutz Medical Campus are working to build a “homegrown” antibody test. Once they do, they say, they are equipped for dispersal to all corners of the state and can help lead the way in corralling the novel coronavirus in Colorado.

Given a shortage of components in the commercial market for developing tests, and a question of accuracy surrounding many of the manufactured kits, the recently formed serology working group sees the approach as a better way to get them back into their labs, solving the many mysteries of the worldwide pandemic.

The collaborative effort involves more than 20 experts from various entities, including UCHealth University of Colorado Hospital and Children’s Hospital Colorado. While they hope to have a test within weeks, members emphasize that the path ahead is long, and an antibody test is only one tool in the battle against COVID-19.

A better approach to a critical mission “Instead of relying on the commercial supply line for antibody-based testing for past exposure to SARS-CoV-2, we are planning to ‘home grow’ the testing by assembling the components and using resources here on campus,” said Dara Aisner, MD, PhD, associate professor in the Department of Pathology of the virus that causes COVID-19. The same approach has been taken at other leading medical centers, including Mount Sinai and Stanford, she said.

Accurate, widespread antibody testing remains critical for better understanding the novel coronavirus and for guiding epidemiologists and state leaders in making crucial related decisions. An important part of the serology group’s effort includes growing a central biobank on campus for collecting recovered COVID-19 patients’ blood and other biological samples and creating an extensive screening plan.

Finding the COVID-19 secret wanderers “We have no idea right now how many Coloradans are walking around with antibodies,” said Ashley Frazer-Abel, PhD, an assistant research professor in the School of Medicine and director of the CAP-accredited Exsera BioLabs on campus. Without that information, critical questions for moving forward are left unanswered, she said.

Because supply of commercial tests for confirming infection failed to meet demand, mostly only hospitalized and high-risk patients have been tested for the virus. With a predicated majority of people contracting the virus having mild or no symptoms, combined with a history of false readings with the initial tests, experts believe many cases are undocumented.

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That suspected void makes accurate calculation of infection and mortality rates impossible, Frazer-Abel said.

Moreover, doctors still don’t know for sure if infection provides immunity or for how long, a critical question in social-distancing decision-making and in vaccine and therapeutic research. “This gives us the denominator for answering those questions,” she said.

“In the case of COVID-19, the virus has several proteins that are antigenic, meaning that people’s bodies produce antibodies to them,” Aisner said. “Once you’ve figured out what antigen to use to make your test, you make it synthetically.” To perform the rest of the test, researchers use blood from patients who have recovered from COVID-19 to determine whether the antibodies in their blood detect the synthetically made antigen.

As part of the effort, the working group has also been validating commercial antibody tests for the state, and researchers will compare their “home-grown” test with other tests currently in use, said Liping Yu, MD, associate research professor with the Barbara Davis Center for Diabetes (BDC). “If our assay is more specific and more sensitive, then hopefully they will accept our technology to serve the whole state and campus employees.”

Medical campus fertile ground for success With the experience and expertise on the CU Anschutz Medical Campus, the group is confident their efforts will have an impact. “We’ve done laboratory tests before and know how to get them to validation,” Frazer-Abel said. “And we have some really exciting ideas.”

“This is also potentially scalable at a completely different level than when basing what you are doing on one commercial kit,” Aisner said. “We could build the capacity to test hundreds of thousands of people with this across multiple labs.”

COVID-19 UPDATE

Building it better, stronger, faster “All antibody tests are designed a little bit differently and measure slightly different things,” said Brian Harry, MD, PhD, assistant professor in the Department of Pathology, explaining the fundamental basis of developing antibody tests.

Liping’s lab has been developing autoantigen tests for autoimmune diseases for 30 years, pumping out 200,000 type 1 diabetes tests annually. “So, he is able to readily adapt that technique to test for coronavirus,” said Lori Sussel, PhD, BDC research director and part of the working group.

Liping, who uses the highly sensitive electrogenerated chemiluminescence (ECL) technology, said the campus SARS CoV-2 antibody test will be highly specific with a high-output capability. “One person in the lab can do thousands of samples a week.”

The campus effort becomes even more critical with the governor’s recent loosening of social-distancing mandates, said Kevin Deane, MD. “And it gives the campus a great opportunity to not just work among ourselves, but to partner across the campus, community and state.”

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DIABETES NEWS

SICK DAY PLANNING At some point, you have probably talked to your doctor about sick day

planning and how to manage your type 1 diabetes when you come down with an illness like the flu or a cold. But when was the last time you updated your plan? Being prepared and knowing what to do if, or rather when, you get sick with some sort of bug is very important.

PREPAREDNESS IS KEY Check the medicine cabinet, pantry, and your diabetes supplies to make sure you have what you need to last a few weeks or more. Here is what the CDC recommends: Medicines and supplies: • Milk of magnesia • Medicine to control diarrhea • Antacid • Thermometer • Suppositories to treat vomiting • Pain reliever and fever reducer – Be aware that medicines containing acetaminophen (like Tylenol) can interfere with some CGM devices

Medicines and supplies: • Sports drinks • Juice boxes • Crackers • Applesauce • Regular soft drinks • Canned soup If you don’t have an appetite or can’t keep down meals, then easy-to-fix foods, snacks, and drinks will help you maintain your carbohydrate intake (about 50 grams every 4 hours).

IF YOU GET SICK

Blood sugars can be difficult to manage when you are sick. Your body is already working overtime to fight the illness, plus you may not be eating or drinking normal amounts. It’s a good idea to test your blood sugar more frequently when you are sick. And don’t solely trust your CGM – some medicines can affect the device readings so double check with a finger poke. Be sure to track the results in case your doctor needs more information.

Continue to take your insulin as usual. You don’t want to risk diabetic ketoacidosis (DKA) because you have too little insulin on board. Weigh yourself each day since weight loss can be a sign of high blood sugar. Check your temperature with a thermometer each morning and evening to keep an eye out for fever. And as always with illness: plenty of fluids and rest will do your body good.

IF YOU SHOW SYMPTOMS OF CORONAVIRUS Seek emergency medical attention if you have trouble breathing, persistent pain or pressure in the chest, new confusion, inability to stay awake, or bluish lips or face.

Keep track of which symptoms of coronavirus you are experiencing. These include, but are not limited to cough, shortness of breath, fever, chills, muscle pain, sore throat, and new loss of taste or smell.

Stay at home, except to get medical care. Most people with mild symptoms can recover at home with the help of fluids and rest. If you do need medical care, call your doctor beforehand for instructions. If you need emergency medical care, call 911 first.

Separate yourself from other people and pets in your household. Try as much as possible to stay in a specific room and use a separate bathroom if possible. Do wear a cloth face mask if you need to be around others.

Clean and disinfect the house anytime someone is sick.

Using gloves, clean with household cleaners or bleach, but never mix different cleaning products. Wash clothes and bedding on the warmest appropriate water setting and dry completely.

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By Paige Lindbloom, Community Engagement Manager

I have had type 1 diabetes for 15 years and throughout my time with diabetes, I have never had a digital doctor’s appointment or “telemedicine” experience. My family even moved to Colorado in 2007 for the amazing care the Barbara Davis Center offers, and I have been going to appointments in person every 3-4 months since. My visits have always been in person with an A1C, device download, and one-on-one doctor attention. With the new Coronavirus pandemic, I was slightly worried about how my care plan and upcoming visit would be impacted and if I would even be able to have a beneficial appointment at all.

My original appointment with Dr. Polsky was scheduled for March 30th, but I received a call from the BDC on March 24th asking if I would like to reschedule for a telemedicine visit. At first, I was a little nervous about a new appointment! My visits are usually such an event in my daily life where I have to travel, pay for parking, check in all of my diabetesrelated devices, etc. etc. etc.

It seemed difficult in my mind to have a successful appointment where my doctor can’t have the face to face interaction with me that I am used to and that they may not be able to successfully evaluate my current care plan to make changes. Knowing that I couldn’t put off my appointment any longer (I hadn’t had a visit in 6 months, sorry mom!) I scheduled my first telemedicine visit for March 27th.

With directions received via email from the BDC staff, I uploaded my pump and CGM data to Carelink for my doctor to view. Once I completed that step, I joined a video call with my endocrinologist. The biggest difference of this digital visit was seeing Dr. Polsky in her home! It made the call feel more like a chat with a friend than a doctor’s appointment.

Granted, we discussed my current time in range (instead of A1C as a better indication of BG control), my ratios, and any problems or questions I may have.

Dr. Polsky and I had conversations about the data, how to adjust doses for high/low BG trends, and more. It was the exact same as an actual visit to the BDC, but it felt a lot less formal!

DIABETES NEWS

MY FIRST TELEMEDICINE VISIT

"It made the call feel more like a chat with a friend than a doctor’s appointment."

Thinking back to before my visit, I wish I wasn’t as worried. The appointment was effortless, and I was able to see my data, get feedback, and ask questions the same as any appointment I have had in the past.

I have already rescheduled my next visit for July and whether it’s in-person or over a webcam, I know I will be receiving the same amazing care I have been getting for the past 13 years.

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DIABETES NEWS

IS HUMAN INSULIN (WALMART INSULIN) SAFE FOR YOU?

By H. Kaan Akturk, MD and Viral N. Shah, MD

The discovery of insulin during the summer of 1921 by Banting, was one of the most influential discoveries in medical history. It has saved lives of millions of people living with diabetes around the world. In 1923, Banting, Collip, and Best sold the patent to the University of Toronto for $1 in a hope that insulin will be accessible and affordable to all who need it. Now, insulin is one of the costliest life-saving medications in the USA. Unfortunately, many deaths have been reported due to lack of availability or unaffordability of insulin around the world.

Currently, we are living in an unprecedented time where a novel coronavirus (SARS-CoV-2) had already infected 1.3 million people in the USA and resulted in more than 80,000 deaths at the time of writing. An unintended consequence of preventing the spread of this virus has resulted in more than 24 million people losing their job. This resulted in a great toll on people living with a chronic condition such as type 1 diabetes. Many questions have been raised on insulin affordability during this time and many people are wondering about the use of older insulins such as human insulin (e.g. Walmart ReliOn insulin) to reduce their insulin cost. In this review, we intend to provide details on different types of insulin preparation and how they are different and some common questions you may have around human insulin use.

WHAT ARE THE DIFFERENT T YPES OF INSULIN AVAIL ABLE IN THE MARKET? After the initial discovery of insulin by Banting and Best, Insulin was purified from animal pancreas (cows and pigs), commonly known as Bovine or Porcine insulin. These insulins are no longer available in the market.

In early 1970, researchers made insulin from E.Coli (a type of bacteria) using recombinant DNA technology.

These insulins are like human insulin.

Examples of these types of insulin are Humulin-R (Regular insulin) and Humulin-N (N stands for NPH, intermediate-acting insulin), Novolin-R, and Novolin-N.

Human insulins were not perfect, and they have unpredictable absorption.

Therefore, scientists have modified amino acid sequences to develop rapidacting and long-acting insulin called as insulin analogs. Examples of insulin analogs are Lantus, Levemir, Tresiba, Toujeo, and Basaglar.

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DIABETES NEWS HOW ARE INSULIN ANALOGS DIFFERENT FROM HUMAN INSULIN? Insulin analogs are different from human insulin in many ways such as they have different onset and duration (see the table below). Therefore, human insulin-R should be taken 30-40 minutes prior to meal (depending on blood glucose level) compared to analogs that you can take 15-20 minutes prior to meal. Also, the absorption is unpredictable with human insulin compared to insulin analogs, and therefore, human insulin is associated with increased risk for low blood sugar in type 1 diabetes.

Onset

Peak

Duration

NPH (N)

2-4 h

4-10 h

12-18 h

Regular (R)

30-50 min

2-3 h

8-10 h

Premixed 70/30 N/R

30-50 min

2-6 h

12-18 h

Detemir

3-4 h

3-9 h

18-22 h

Glargine

2-6 h

none

20-24 h

Degludec

1-2 h

none

40-45 h

Lispro

5-15 min

30-90 min

4-6 h

Aspart

5-15 min

30-90 min

4-6 h

Glulisine

5-15 min

30-90 min

4-6 h

Premixed 70/30 or 75/25

5-15 min

2-4 h

14-24 h

HUMAN INSULIN

ANALOG INSULINS

Continued on next page

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DIABETES NEWS

WHAT IS THE COST PER VIAL OF HUMAN INSULIN VS INSULIN ANALOG?

As of May 2020, we searched the retail price of different insulin (U-100) on Good Rx website. Cost of various insulin per vial is provided in Table below. increased risk for low blood sugar in type 1 diabetes.

Brand name of insulin

Scientific name/ Company

Cost per vial #

Humalog, Generic

Insulin Lispro, Eli Lilly

$165

Humalog, Brand

Insulin Lispro, Eli Lilly

$324

Novolog, Generic

Insulin Aspart, NovoNordisk

$174

Novolog, Brand

Insulin Aspart, NovoNordisk

$310

Admelog, Generic

Insulin Lispro, Sanofi

$146

Apidra, Brand

Insulin Glulisine, Sanofi

$378

Afrezza, Brand

Technosphere inhaled insulin, Mannkind

$347 (90 cartridges of 4 units)

Levemir, Brand

Insulin Detemir, NovoNordisk

$330

Lantus, Brand

Insulin Glargine, Sanofi

$315

Basaglar, Generic

Insulin Glargine, Eli Lilly

$390 (5 pens)*

Toujeo, Brand

Insulin Glargine, Sanofi

$324 (3 pens)*

Tresiba, Brand

Insulin Degludec, NovoNordisk

$599 (5 pens)*

Humulin N

Eli Lilly

$179

Humulin R

Eli Lilly

$172

Humulin 70/30

Eli Lilly

$173

Novolin N

NovoNordisk

$25

Novolin R

NovoNordisk

$25

Novolin 70/30

NovoNordisk

$25

ReliOn insulin-R and N

They are manufactured by NovoNordisk and same as Novolin R and N.

$25

INSULIN ANALOGS

HUMAN INSULIN

# this is average retail price based on GoodRx. This cost may be different depending on geographical area, use of coupons, your insurance plan and formulary within your plan. Also, cost for insulin pen is different than vial. *These products are available as pen only.

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Those who are on insulin pump and those who cannot change to human insulin due to various reasons can get some support from companies to lower the cost of insulin analogs.

Companies have support programs and if you are eligible, you can apply either online or through paper application. After the COVID-19 financial crisis, insulin manufacturing companies initiated financial support programs too. We mentioned a few support programs below however it is better to check company website for recent updates. Regulations and rules of financial support programs are subject to change anytime. Programs available include free insulin for eligible patients, capping insulin prices at $99, and so on.

1. NovoCare and patient assistant programs from Novo Nordisk: www.NovoCare.com

2. Eli Lilly Insulin Affordability programs:

IS HUMAN INSULIN RIGHT FOR YOU? Type 2 diabetes There is still some pancreas function so human insulin use may cause less problems compared to type 1 diabetes. There is more evidence that in higher HbA1c in patients with type 2 diabetes, human insulin may be safer. For lower HbA1c, evidence is lacking.

Type 1 diabetes If you are on insulin pump: There is not enough data for human insulin to use in a pump effectively. There is literally no information to use in hybrid closed loop since all studies are done with rapid insulin analogs.

We recommend not using human insulin through insulin pump unless suggested by your provider.

If you are on injections: Human insulin has a different physiology than insulin analogs. Hypoglycemia risk is higher with human insulin compared to analogs in type 1 diabetes. Most individuals with type 1 diabetes, human insulin is not the best choice. We suggest you discuss with your diabetes provider if human insulin is right for you and how to use it safely and effectively.

DIABETES NEWS

IS THERE ANY SUPPORT FROM INDUSTRIES ON INSULIN ANALOGS?

www.InsulinAffordability.com

3. Sanofi Insulins Valyou Savings program: www.InsulinsValYOU.com

CONCLUSION Human insulin is a cheaper alternative to insulin analogs. Using human insulin seem less problematic in type 2 diabetes comparted to type 1 diabetes. But for patients that plan to use human insulin, best approach is to discuss with their providers and plan of transition. It is vital to know how each insulin is working and how to make changes in meal planning, exercise and administration frequency.

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#BDC40

40 TH ANNIVERSARY OF THE BARBARA DAVIS CENTER In May 2020, we marked the 40th anniversary of the Barbara Davis Center for Diabetes, albeit in a more muted fashion than we would have hoped. We took the necessary safe steps in light of COVID-19 to cancel any kind of celebration to mark the occasion, but the story of this amazing medical center is one that still needs to be recognized.

In 1978, Marvin and Barbara Davis founded both the Children’s Diabetes Foundation (CDF) and the Barbara Davis Center for Diabetes (BDC) after their daughter, Dana, was diagnosed with type 1 diabetes. Living in Denver at the time, they were frequently traveling to Boston for Dana’s care and knew there had to be a better solution closer to home.

The BDC would provide state-of-the-art care to type 1 patients and devote research to finding a cure for the chronic auto-immune disease. Meanwhile, CDF would function as the nonprofit fundraising arm of the Center, providing the necessary resources and volunteers to keep the BDC open and operational.

Marvin and Barbara generously donated a portion of their personal wealth for the building in 1978. Construction on the original Barbara Davis Center was completed in 1980 at the Ninth Avenue campus on Colorado Boulevard in Denver, Colorado. The building was expanded in 1983, 1986, and again in 1994 as more and more space was needed to treat patients and continue research.

In May 2005, the BDC relocated to its current location. Housed in a dedicated building on the Anschutz Medical Campus in Aurora, Colorado, the Center is an independent institute within the University of Colorado School of Medicine. BDC clinical faculty members teach medical, physician assistant, nursing, and dental students on campus. Residents and endocrinology fellows receive critical training at the leading edge of diabetes clinical care and research.

The BDC proudly provides state-of-the-art diabetes care to more than 7,500 children and adults with diabetes, as well as provides inpatient care to patients with any type of diabetes who are seen at the nearby Children’s Hospital Colorado. Of those thousands of patients, approximately 40% are uninsured or underinsured, meaning they may not have the ability to pay for their care or treatment. Thanks to support programs of the Children’s Diabetes Foundation, no one is turned away for care and families do not have to choose between the insulin their child needs and a roof over their head.

Marvin and Barbara had a dream more than 40 years ago, that the best possible diabetes care would be available to anyone and everyone who might need it. Not only would their daughter Dana receive the top-notch care and attention every parent wants for their child, but any patient who walks through the BDC’s doors would be welcomed just the same, as part of the Davis family.

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I am very proud of the Barbara Davis Center and the work we have accomplished in the last 40 years. I get very sentimental about it because this hospital was built out of love for a child, my daughter Dana, so that she and the rest of the world might have access to the best diabetes care available from the very best doctors.

I cherish the feeling of knowing we can provide such a high level of care and supply life-saving insulin to our patients, regardless of their ability to pay for it. More than a third of our patients would not be able to afford treatment elsewhere if not for the Barbara Davis Center and the support of the Children’s Diabetes Foundation.

#BDC40

REFLECTIONS FROM BARBARA DAVIS

We would not be here today without you, our very special patients.

When the FDA passed approval of the artificial pancreas, it was based on data and research from BDC patients. Our facility was chosen because so many of you were willing to participate in the kind of research that moves the diabetes world ever forward.

This facility is staffed by some of the most incredible people you will ever meet. We love our BDC patient care teams, researchers, administrators, and support staff, as I know you do too. I am so proud that we have these talented people on our team, caring deeply and working tirelessly to advance the treatment of type 1 diabetes. I can remember fondly that at one point we did so many transplants, and did them so fabulously, that our transplant doctor was made the head of transplants at the Mayo Clinic, a world-famous medical institute. This is the high level of skill and ability that our Center attracts.

These last 40 years have shown me what great work has been done here. This anniversary is such a great accomplishment and the success of this Center means so much to me. The Barbara Davis Center for Diabetes and the Children’s Diabetes Foundation touch so many lives and I am so happy to be a part of all the victories that could have been tragedies.

As I said in the beginning, this special place was built out of love for my daughter, Dana Davis. Nothing means more to you than your own children and Dana, now Executive Director of the Children’s Diabetes Foundation, has been an absolute inspiration. I thank her for her years of service and dedication to this fight, one that she never asked to be a part of.

Thank you to all the doctors for the great work they have done over the last four decades and the great strides they have made in our field.

My special thanks to all of you, for being so supportive and so caring.

I want you to know how much you mean to the success of these organizations. One day we will find a cure for this terrible disease and I want you to know it will be YOU who made all the difference in so many lives.

With love and appreciation,

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FOUNDATION NEWS

IN MEMORIAM - STEVE FARBER Steve Farber passed away in March of this year and the staff and board members

of CDF were deeply saddened to learn of his death. He was 76. Steve was a longtime supporter and board member of the Children’s Diabetes Foundation and we are so thankful to have had years of his support, service, and friendship.

“Throughout his career, Steve was one of the most respected and accomplished leaders in the country. He inspired change not only at the firm, but throughout Colorado and across the nation,” said his longtime business partner Norm Brownstein.

A message from Barbara Davis: Marvin Davis and I have been best friends with the Farber and Cook Families from the day we arrived in Denver. We drove Cindy to her first lunch date with Steve. From the moment I met him, he stood out as not only a great lawyer, but as a great human being who not only did Cindy fall in love with, but Marvin and I loved him too. We have loved Steve and Cindy, Debbie and Jimmy, Shelly and Rick and their families, they are the most wonderful family and they were very close to us. Steve, being a lawyer, had the greatest integrity, brilliance, kindness, and respect of everyone he met, he was a loving and special friend. Steve always gave the greatest advice, and was a brilliant lawyer and a very special human being.

Steve will be missed not only by his wife and children, but the world will miss him, his family will miss him and my family and I will miss him.

Steve, you leave us with love.

Cindy, my darling, my deepest sympathy.

With love, Barbara Davis A companion book to “The First Book for Understanding Diabetes”

for the challenge of our child’s diabetes, but this book paved the way for the acceptance and handling of this change in our lives.”

For additional copies of the publication, contact:

Children’s Diabetes Foundation 4380 South Syracuse Street, Suite 430 Denver, CO 80237 Phone: 303-863-1200 www.ChildrensDiabetesFoundation.org

UNDERSTANDING DIABETES

“Nothing could totally prepare us

ISBN barcode here

A handbook for people who are living with diabetes

H. Peter Chase, MD and

www.pinkpanther.com

Big thanks to our friends at Volley 4 Charity for their

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continued support of CDF and the Barbara Davis Center.

Their volleyball tournament in February of this year raised more than $22,000 for CDF. We appreciate all their hard work and thanks to the amazing players for bringing the action!

14th Edition

THE PINK PANTHER™ & © 1964-2020 Metro-Goldwyn-Mayer Studios Inc. All Rights Reserved.

Brigitte I. Frohnert, MD, PhD Barbara Davis Center

The Children’s Diabetes Foundation is excited to announce for Diabetes

an updated 14th edition of Understanding Diabetes will be 14thhas Edition coming later this summer. This publication long been an invaluable resource for those living with type 1 diabetes and their caregivers. Learn more and grab your discounted 13th edition at ChildrensDiabetesFoundation.org/books

THE BARBARA DAVIS CENTER IS

NOW SCHEDULING SUMMER APPOINTMENTS! There are 3 easy ways to schedule:

- Use MyChart - Call the ront es at 3 3- - 3 3 - mail atie ( atelin.thi%ener@cuanschutz.edu) or Rhea (rhea.allingham@cuanschutz.edu)

We are beginning to open the clinic to a limited number of in-person visits and will continue home telemedicine visits through the summer. If your appointment needs to be set up for home telemedicine, we will reach out to you within a week of the appointment to prepare you.

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GIVEBACK7993

June 19th & 20th only!

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Saturday, August 1, 2020

Presented by:

VIRTUAL

5K

RUN & WALK

Registration open now at RUNSIGNUP.COM/RUNFORTHERING 19

NEW DATE! AUGUST 31, 2 020 P I N EH U R S T C O UN T RY CL UB

TIED TO A CURE DENVER GOLF TOURNAMENT RESERV E YO UR F O URS O M E N O W A N D S UPPORT T YPE 1 D IA BE T ES CA RE AN D RES EA RC H AT CHILDREN SDI AB E T ESF O UN D A TIO N.O RG 20

N E W

D A T E !

|

S E P T E M B E R

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C H I L D R E N S D I A B E T E S F O U N D A T I O N . O R G

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The Carousel of Hope Join us as we fight to find a cure and care for the millions of people living with type 1 diabetes and celebrate Barbara Davis’s 90th Birthday!

Saturday, October 10, 2020 Beverly Hills, California 22

Children’s Diabetes Advisory Board Members and Guild Presidents THE GUILD PRESIDENTS:

ADVISORY BOARD:

Founding President, Amy Davis Mrs. Gina Abou-Jaoude Mrs. Christy Alberts Mrs. Jamie Angelich Mrs. Karen Aylsworth Mrs. Linda Broughton Mrs. Tangy Buchanan Mrs. Joy Burns Dr. Bonita Carson Mrs. Lisa Corley Mrs. Nancy Cowee Mrs. Dalyla Creaghe Mrs. Norma D’Amico Ms. Donna Douglas Mrs. Margy Epke Mrs. Chris Foster Mrs. Helenn Franzgrote Mrs. Sally Frerichs Mrs. Debbie Gradishar Mrs. Helen Hanks Mrs. Georgia Imhoff Mrs. Marty Jensen Mrs. Gail Johnson Mrs. Sharon Kamen Mrs. Janet Knisely Mrs. Cheryl Lebsock Mrs. Shelley Lucas Mrs. Suzy Love Mrs. Judy McNeil Mrs. Sally Newcomb Mrs. Barb Oberfeld Mrs. Gretchen Pope Mrs. Carol Roger Mrs. Kay Stewart Mrs. Diane Sweat Ms. Charlotte Tucker Mrs. Loretta Tucker Mrs. Melissa Tucker Mrs. Jane Weingarten

Sir Michael Caine Mr. and Mrs. Robert A. Daly The Honorable Diana DeGette, U.S. House of Representatives, Colorado Mr. Neil Diamond Mr. Placido Domingo Mr. John Elway Mr. David Foster Mr. Kenny G Mr. David Geffen Mr. Magic Johnson Mr. Quincy Jones Ms. Sherry Lansing Mr. Jay Leno Mr. Paul Marciano Mr. Mo Ostin Sir Sidney Poitier Mr. Lionel Richie Mrs. Adrienne Ruston Fitzgibbons Mr. George Schlatter Ms. Maria Shriver Mr. Steven Spielberg and Ms. Kate Capshaw Ms. Brenda Richie Ms. Barbera Thornhill Miss Joan van Ark Mr. Gary L. Wilson Mr. Stevie Wonder See complete list at ChildrensDiabetesFoundation.org

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Nonprofit Org. U.S. POSTAGE

PAID Children’s Diabetes Foundation 4380 South Syracuse Street Suite 430 Denver, CO 80237

Change Service Requested

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Denver, CO Permit No. 1752