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them. These measures of precaution are by no means unnecessary.

An officer had saturated his cigarettes and cigars with a solution containing opium, and smoked for twenty-four hours almost without interruption. Another officer had slipped morphine between the soles of new slippers. Other individuals concealed immediately after their arrival morphine in powder in the upholstery of the sofa, upon the canopy and in the ventilators of the windows. Other patients enclosed morphine in envelopes of thin paper, which were placed between the leaves of their books, stitched it in the folds and lining of their garments, etc.

The first symptoms of the withdrawal of the drug show themselves in delicate individuals at the end of three or four hours, and in robust persons about fifteen hours, after the last dose. These symptoms consist of malaise, restlessness, a sense of muscular tension, chilly sensations, and the like, but do not demand treatment. As soon as shivering commences the patient must be put to bed—a measure to which, as a rule, he readily assents on account of the sense of muscular fatigue now experienced. For the relief of the headache, which is rarely absent, applications of cold water or of ice or etherdouches to the forehead may be employed. For the distressing gastralgia compresses moistened with chloroform may be applied to the epigastrium. The colic, which is often distressing, may be treated by sinapisms or hot compresses. The nausea and vomiting and epigastric distress, which are apt to continue for several days, may be treated by a solution of bicarbonate of sodium with tincture of nux vomica and essence of mint. If the vomiting be excessive, recurring twenty or thirty times in the course of twenty-four hours, small doses of morphine by the mouth must be given. If by reason of the continued vomiting and inability to retain nourishment dangerous exhaustion develops, nutritive enemata must be administered. The diarrhœa requires little treatment during the early days. If, however, it be excessive and persists beyond the third or fourth day, large enemata of warm water of a temperature of 98° F., repeated two or three times during the day, are attended by excellent results. The insomnia, which constitutes a most distressing symptom, defies every kind of treatment during the first three or four days. During this

time prolonged baths are not well borne, and even when they are employed they scarcely produce more than half an hour or an hour of sleep. Chloral is also, under these circumstances, inadmissible, whether administered by the stomach or by the rectum. It does not induce sleep, and its employment is very often followed by a high degree of excitement. After the fourth day it is well borne by many persons, and manifests its usual hypnotic property. Warm baths of five minutes, followed by cold affusions, exert an excellent influence upon the general debility and mental depression of the first days.

The objections of patients to these baths cease after they have experienced the excellent results which follow their use. During the bath stimulants, such as champagne, port, and hot bouillon, may be given. Care must be paid to the alimentation from the very beginning of the treatment. During the first days liquid nourishment should be given, and abundance of wine and other alcoholic beverages according to the previous habits of the patient. Some nourishment is to be given every hour or every two hours. Many patients experience an intense craving for alcoholic drinks; others, on the other hand, are unable to take them. To the former wine, beer, etc. may be given freely during the first three or four days; to the latter a restricted milk diet may be given, one to two quarts in the course of twenty-four hours. Such is the method of Levinstein, to which he adds, however, important modifications for those—and their number is large—who are unable to bear the abrupt withdrawal of the drug.

This method is attended in all cases by indescribable sufferings, and in many by serious dangers. Among the last, collapse and delirium tremens demand special consideration. The collapse which occurs in a certain proportion of the cases requires prompt and energetic treatment. The pulse becomes feeble, small, gradually or suddenly diminishes in frequency; the countenance is pale; the previous agitation gives place to an ominous calm; there is a tendency to syncope, accompanied by persistent somnolence and slowing of the respiration. Inhalations of ammonia and the administration of aromatic spirits of ammonia, champagne, brandy, or hot coffee, with frictions of the surface and cold applications to the head, may occasionally produce reaction. As a rule, however, it is necessary to

administer a hypodermic injection of morphine. This condition of collapse, once having shown itself, is apt to recur upon the same or the following day. The treatment of the delirium tremens consists in isolation, the administration of abundant nourishment, the use of the bromides, chloral, or paraldehyde, with alcoholic stimulants. As this complication is unattended by danger to life, and usually disappears in the course of a few days, the administration of morphine is not required.

The modifications of this method suggested by Levinstein for those who are unable to bear the abrupt suppression of the drug are as follows: The patient is isolated and guarded; for two or three days his habitual dose is administered, this duty being performed by the physician himself. The drug is then abruptly discontinued. At the end of twenty-four hours the phenomena of abstinence are manifested; the pulse loses its regularity, distressing diarrhœa and vomiting occur, etc. These symptoms are controlled by the injection of morphine, the dose being much smaller than that to which the patient has been accustomed. By this means the sufferings of the patient are ameliorated, and the dangers attendant upon the rapid suppression of the drug are averted. At the end of twenty-four hours it becomes necessary to again administer the drug, but in diminished dose. After a time it is discontinued altogether. b. The Gradual Diminution of the Dose.—This method is now generally employed. It consists in isolation of the patient with proper attendants and the progressive diminution of the dose. The drug should always be administered by the physician himself. The rapidity with which it is suppressed will be determined by the circumstances of the individual case. The time occupied should not exceed ten days. In the majority of cases it will be much shorter than this. If the administration of morphine to correct urgent symptoms be at all required after this time, it will be at most on one or two occasions at intervals of twenty-four or forty-eight hours. When the process of reducing the dose is too greatly prolonged, the sufferings of the patient are unnecessarily aggravated. As the diminution progresses the relief produced by each dose is followed by distressing reaction.

The anticipation of smaller doses from time to time or from day to day is a matter of great distress to patients. After a while their courage and endurance fail them, and they seek by every possible means to secure at least one good dose of the coveted drug.

The symptoms produced by the suppression of the drug speedily show themselves, increasing in intensity as the dose diminishes.

Temporary amelioration is, however, produced by each of the successively diminishing doses of the drug. Whatever may have been the method followed by the patient, the hypodermic injection of morphine is to be preferred in the treatment. The disturbances of the digestive system which speedily appear require but little special medication. The danger of inanition which attends the complete loss of appetite, the inability to take ordinary food, and the frequent often uncontrollable vomiting, are best met by the systematic administration of easily assimilable liquid diet, consisting of limewater and milk, milk and Vichy water, pancreatized milk, koumiss, concentrated broths, the expressed juice of fresh partly-cooked beef, and the various commercial foods used in the artificial feeding of infants. Vomiting rarely occurs immediately after the ingestion of articles of this kind. If it takes place in the course of an hour, some degree of digestion and absorption will have taken place. Should, however, all food be rejected by the stomach, efforts at rectal alimentation must be attempted. Efforts to control the vomiting by medicines other than the administration of opium or morphine in some way are not usually attended by success. The diarrhœa is usually frequent, the stools being liquid, sometimes small, often copious, and amounting in number from eight or ten to thirty or more in the course of twenty-four hours. They are not usually attended by pain. Some relief to this symptom follows the administration for a time of large doses of bismuth subnitrate (grs. xx to xxx) every second, third, or fourth hour. The sinking feeling at the pit of the stomach and the epigastric pain are to some extent alleviated by external applications. Hot fomentations or compresses containing a few drops of chloroform or turpentine are also useful.

The derangement of the respiratory system, which consists usually in a certain amount of bronchitis with more or less cough and some dyspnœa aggravated by exertion and movement, does not usually require special treatment.

Disturbances of the circulation constitute a very important group of symptoms, and require close watching always, active interference frequently. For the relief of the phenomena due to flagging action of the heart the recumbent posture, external warmth, friction of the extremities, the application of turpentine stupes or mustard to the præcordial and epigastric regions, the inhalation of ammonia or the administration of preparations of ammonia, and sometimes digitalis, which may be given either by the mouth or hypodermically, will be required. Alcohol, however, will prove in the greater number of cases a most useful remedy—in many an indispensable one. It may be given in the form of milk-punch, hot toddy, or of port, champagne, etc., according to the requirements of the case. Failure of the circulation may, notwithstanding every effort to control it, reach such a degree as to jeopardize the patient's life. Under such circumstances the treatment must be interrupted by the immediate administration of small but efficient doses of morphine, which, if necessary, must be repeated. As diarrhœa increases the quantity of urine excreted rapidly diminishes. It may not exceed eight or ten fluidounces in the course of twenty-four hours. After the third or fourth day of the treatment the urine in a considerable proportion of cases contains albumen and occasionally casts. The oliguresia is largely due to the excessive loss of fluid by the bowel, and does not require treatment. Nor, indeed, is active treatment demanded by the albuminuria, which usually spontaneously subsides in the course of a few days, although it sometimes persists for some weeks or months. Persistent albuminuria requires appropriate treatment.

The nervous symptoms, which constitute a most important group, are favorably influenced by methodical alimentation and the free use of alcoholics. Care must be taken to reduce the amount of alcohol administered as convalescence progresses. With the reestablishment of the normal functions of the body, the disappearance

of insomnia, and improved nutrition, alcohol may in the majority of cases be rapidly diminished or wholly withdrawn. This course, favored by the regular life which the patient should be obliged to lead on becoming convalescent, and the feeling of general bienaise which is gradually developed as the cure progresses, is rendered especially important by the fact that a considerable proportion of opium-habitués are individuals of unstable nervous organization, which in itself constitutes a powerful predisposing influence to alcoholism.

It seems hardly necessary to describe in detail the treatment demanded for the relief of the varied disturbances of the nervous system. The use of coca in the form of a good preparation of the wine or fluid extract in appropriate doses, to which may be added tincture of cannabis indica, exerts a favorable influence. The administration of cocaine by the mouth and hypodermically has in some instances seemed to me to be followed by favorable results. It is not, however, to be adopted as a routine practice, by reason of its occasional depressing effect and the possible danger of replacing the opium habit by a craving for cocaine. Lupulin, and in particular an ethereal extract of lupulin, exerts a favorable but not very powerful influence in tranquillizing the nervous system. With the view of controlling to some extent the insomnia, the hypodermic injections should, during the early part of the treatment, be so timed that the period of sleep or drowsiness which they produce should occur during the night. As soon as the number of injections is reduced to one daily, that one should be administered at the latest convenient hour before midnight. For twenty-four or forty-eight hours after the final discontinuance of morphine but little effect may be expected from ordinary doses of other sleep-inducing drugs. Chloral in single large doses (grs. xx to xxx), either alone or associated with a corresponding large dose (grs. xl to lx) of one of the bromides, administered on the second or third night after total suppression, is very often followed by prolonged, tranquil, and refreshing sleep.

Caution must be observed, however, in administering chloral so long as the indications of feeble circulation persist. Paraldehyde, although less certain, is a less dangerous hypnotic under such circumstances.

Massage, hot baths, and the cold pack are all useful adjuvants to the treatment. The sweating when copious and distressing is favorably influenced by sponging with hot alcohol.

The abject mental state of the patient calls for much firmness, gentleness, and tact on the part of the physician and attendants.

Every effort should be made to inspire courage and hope. Neither the importance of the symptoms nor the intensity of the sufferings of the patient should be underrated; nevertheless, the ordeal is a limited one. In the majority of instances, to get rid of the opium means to get well, because opium, unlike alcohol, does not leave permanent structural lesions of any organ. The expectation of a radical cure must therefore be confidently presented to the patient as a consolation in his sufferings.

With the return of convalescence sexual power is restored and menstruation is re-established. Insomnia and muscular weakness usually persist into the convalescence for some weeks, and only gradually yield to careful regulation of the daily life of the patient, with abundant nutritious food, open-air exercise, and change of scene.

The insomnia of this period constitutes a serious symptom, for the reason that it constantly subjects the patient to the temptation to return to the use of hypnotics. In the course of time, however, the normal physical and mental condition is regained, and the patient may be permitted to return to his former pursuits and associations.

The Treatment of the Chloral Habit.—That which has been said in the foregoing pages concerning the prophylaxis against the opium habit applies with equal force to chloral and other narcotics. The curative treatment of habitual addiction to chloral is attended neither by the difficulties nor the dangers which are encountered in the management of the opium habit. The symptoms attending the discontinuance of chloral are less severe and less persistent; in fact, individuals accustomed to the taking of large doses of chloral not infrequently voluntarily discontinue its use for considerable periods of time. As a rule, the treatment may be carried out at home, the patient, however, being isolated and cared for by a watchful

attendant. The drug should be stopped at once. For the first few days alcoholic stimulants should be freely given. Systematic feeding, pepsin, full doses of quinine, followed after a time by strychnia, and, as soon as the condition of the digestive system will permit of it, by iron, fulfil the general indications. Cod-liver oil and malt extracts may be given with advantage. Cardiac failure, collapse, and delirium tremens are to be treated in the same manner as similar complications occurring in the treatment of the opium habit. Vomiting is much less likely to occur, and when present is less persistent and less difficult of management. Diarrhœa does not usually prove troublesome, the bowels, on the contrary, being constipated. The latter condition yields to mild laxatives or to simple enemata.

Hemorrhages from the various mucous tracts may be controlled by fluid extract of ergot, the hypodermic injection of solution of ergotin, minute doses of wine of ipecac, or fluid extract of hamamelis. The conjunctivitis which is occasionally present usually subsides spontaneously upon the discontinuance of chloral. It may be treated by instillations of a 2 per cent. solution of cocaine and mild borax lotions (grs. v to fluidounce j). The after-treatment must be carefully carried out. Relapses are less frequent than after the opium habit.

The Treatment of Habitual Addiction to Paraldehyde, Cannabis indica, Ether, Chloroform, etc. must be based upon the general principles indicated in the foregoing pages. Cases of the habitual abuse of these drugs are comparatively infrequent on the one hand, and on the other do not often present the serious and progressive symptoms produced by excesses in opium and chloral; hence they come but rarely under the care of the physician, except in those unhappy individuals in whom the propensity to vicious narcotism is such that any drug capable of producing excitement and oblivion is made the means of gratification, and all are used by turns as the opportunity occurs.

CHRONIC LEAD-POISONING.

BY JAMES C. WILSON, M.D.

DEFINITION.—The term chronic lead-poisoning is used to designate the morbid phenomena induced by the gradual accumulation of lead in the organism.

SYNONYMS.—Plumbism, Saturnism, Morbus plumbeus, Molybdosis, Molybdonosus, Intoxication saturnine, Bleivergiftung.

CLASSIFICATION.—Chronic lead-poisoning manifests itself in serious disorders of nutrition which are widespread and implicate all the tissues of the body; but for the reason that its more striking and characteristic symptoms relate to the nervous system, it has been classed among disorders of that system as a toxic neurosis.

Acute poisoning by lead is an entirely different affection. It depends upon the power of the salts of lead to coagulate albumen. Its symptoms are those of acute corrosive gastritis; derangements of the nervous system are secondary. It does not fall within the scope of the present article.

HISTORY.—Chronic lead-poisoning must have existed from the infancy of the arts in which the metal is employed. It does not, however, appear to have been recognized until after the time of Hippocrates. Celsus was aware of the danger attending the administration of lead. Nicander, Dioscorides, Aretæus, and Paul of

Ægina recognized lead colic and the paralysis resulting from its longcontinued introduction into the stomach. Among Arabian physicians, Rhazes and Avicenna accurately describe the effects of the preparations of lead. No considerable addition to the knowledge of the subject was made until the seventeenth century. In 1616 was printed at Poitou the famous work of Citois, De novo et populari apud Pictones dolore Colico bilioso Diatriba. The epidemic colic described by this author was caused, although he little suspected it, by the common use of wine which had been treated by lead to remove its acidity. This practice, which is of very ancient date, and is described in the writings of Cato, Pliny, and Columella, was at one period very general in Europe, and had been forbidden by imperial ordinances as early as 1437.1 It remained for Stockhausen, in a treatise published at Goslar in 1656, and entitled De Lythargyrii Fumo, noxio, morbifico ejusque metallico frequentiori morbo vulgo dicto HuttenKatze, to demonstrate that Poitou colic was produced by lead in particles in emanations, and for Wepfer in 1671 to first clearly point out the fact that the epidemic colic so often described was usually caused by lead in wine. During the eighteenth century the epidemic colic attracted much attention among medical men, and its etiology was made clear. Henkel called the affection founder's colic, and showed how it was produced in those engaged in casting lead; Huxham, in his work on Fevers (1745), described the disease as it prevailed in Devonshire, and several English observers conclusively proved that the epidemics of colic frequently appearing in certain districts were caused by the presence of lead in cider, and that it was due to the action of the apple-juice upon lead used in the construction of the presses and implements employed in the manufacture of that popular beverage.

1 Vide Tanquerel des Planches, Lead Diseases, translation by S. L. Dana, M.D.,

LL.D., Lowell, 1848.

During the current century the closer study of the etiological relations of disease has revealed many unsuspected sources of leadpoisoning in the arts, and of lead contamination, both accidental and intentional, in articles of food, drink, and luxury. Hence the literature

of the subject has assumed very extensive proportions. The French physicians have devoted much attention to this subject. The great work of Tanquerel des Planches, to which reference has already been made, remains to this day the most complete and comprehensive authority. Quite recently valuable additions to existing knowledge have appeared in some of the Paris theses.2 2 Vide Capelle, De l'Intoxication saturnine, Paris, 1883; Séguin, Ch., De l'Albuminurie

transitoire des Saturnins, Paris, 1883; Goudot, Étude sur la Goutte saturnine, Paris, 1883; Verdugo, Contribution à l'Étude de la Goutte saturnine, Paris, 1883; and Coutard, La Colique du Poitou considérée comme Intoxication saturnine, Paris, 1884.

ETIOLOGY.—A. Predisposing Influences.—Individuals exposed to lead and its compounds are not all equally prone to its effects. The degree of liability is to some extent dependent upon individual susceptibility, and to a much greater extent upon circumstances which are determined by the season, climate, age, sex, diet, and mode of life of different persons. It will be convenient to consider the predispositions which arise from occupation under the head of the Exciting Cause.

Variations in the degree of susceptibility to chronic lead-poisoning appear to be explicable in a majority of the cases solely upon the theory of idiosyncrasy. While a large proportion of the cases are in well-developed, strong, and previously healthy adults, individuals of feeble constitutions do not escape. Those occupations which involve the greatest exposure to the danger of contracting this affection at the same time demand the powers of a robust frame. Habitual recognition of these dangers, such as begets the habitual exercise of reasonable precautions against them, diminishes to some degree the liability of a few workmen.

Season.—Due allowance being made for the difference in the number of workmen employed in manufactures which involve exposure to lead, and especially in the making of white lead, at different seasons of the year, it has been found that attacks of lead colic and of lead palsy are more common in warm than in cold weather. Heat predisposes to the attack, either by favoring the

dissemination of the lead compounds or by facilitating their absorption by various channels, especially by the skin, which is more freely exposed in summer, and at the same time more or less bathed in sweat in which the dust of lead salts may be dissolved.

Climate.—In the absence of definite statistics upon the subject, it appears probable that the dangers of chronic lead-poisoning would be greater in warm than in cold climates. The clinical features of the affection are alike in all parts of the globe.

Age.—The majority of individuals attacked are adults. Nevertheless, children employed in occupations involving exposure to lead are attacked with great frequency—so much so that it may be concluded that their liability is in fact greater than that of adults.

Sex exerts a decided influence, women being, under nearly similar circumstances, less frequently attacked than the men employed in the same factories—a fact to be explained only by their greater willingness to exercise the recognized precautions.

Diet does not constitute a predisposing influence. It is nevertheless probable that a deficient diet favors the development of the affection.

Excesses in food, and especially excesses in drink, predispose to lead colic.

The mode of life is important. Those who lead sober, regular, and, above all, cleanly lives are less liable to the affection than the intemperate, irregular, and careless. Particularly are the dangers in factories increased by neglect of ventilation. Persons suffering from affections of the digestive tract are not, among lead-workers, more prone to lead colic than their comrades who are free from such diseases.

B. The Exciting Cause.—Metallic lead is probably inert, but, owing to the ease and rapidity with which it oxidizes and forms salts, lead in any form, if introduced into the body continuously for a length of time, produces characteristic toxic effects. The oxides, acetates, and carbonate of lead, being soluble in the gastric juice, act more surely.3

But the sulphate, the least soluble of the lead compounds, may also have this effect (Gasserow).

3 Naunyn, Ziemssen's Encyclopædia, vol. xvii.

The channels by which lead is introduced into the body are the alimentary canal, the respiratory tract, and the cutaneous surface.

Hence the modes of introduction are of almost endless variety. The conveyance of lead into the stomach constitutes the most common as well as the most important means of access to the organism. This may be in the form of medicine, as the acetate, the unduly prolonged use of which, even in moderate doses, sometimes produces chronic poisoning. Articles of diet are not infrequently contaminated by lead derived from different sources, of which the most common is the lead glaze of earthenware vessels, which is soluble in acid fluids.

According to Naunyn, beer drawn through lead pipes may cause chronic lead-poisoning, which has also been frequently ascribed to the use of shot in cleaning bottles used for wine and malt liquors.

Drinking-water is occasionally contaminated with lead derived from pipes made of this metal and cisterns painted with lead colors. Pure water, freed from gases, does not act upon lead when the air is excluded. In the presence of air, however, an oxide of lead is formed which is partially soluble in water. If nitrates, nitrites, and chlorides, such as constitute ingredients of sewage, are also present, they form soluble compounds with lead and increase the proportion of lead salts soluble in the water. For this reason water contaminated by sewage is rendered decidedly more dangerous if carried in leaden pipes. On the other hand, the purer the water the greater the danger.

Hence rain-water and pure spring-water cannot safely be stored in cisterns painted with lead colors nor conveyed in leaden pipes, nor can lead covers be used for cisterns, because of the condensation of the vapor of water, which drops back, holding lead salts in solution.

The sulphates, phosphates, and carbonates usually found in riverwaters form insoluble lead compounds, which, being deposited upon the interior of the pipes, act as protectives and prevent further chemical changes.

Still more common is the accidental conveyance of lead dust and lead compounds to the mouth in consequence of their adhering to the hands or settling from the atmosphere upon articles of food and drink, in the case of workmen engaged in the various arts in which lead is freely used. As a rule, to which the exceptions are rare, the more severe cases of chronic lead-poisoning occur only among workers in lead, as miners, those employed in white-lead factories, painters, typesetters, plumbers, and lapidaries.

Potters engaged in the glazing of common pottery and tiles, workmen in file-factories, workers on colored papers and in enamels, especially in glass enamels, brushmakers for the reason that the bristles are sometimes colored by lead preparations, and those engaged in sewing coarse goods because the thread is sometimes treated with a preparation of lead in order to add to its weight, are likewise liable to chronic lead-poisoning. The introduction of lead into the body through the respiratory tract is a subject of the greatest importance in the trades. Inadequate ventilation of working-rooms, living or sleeping in apartments connected with or contiguous to factories in which lead is largely used, and particularly in leadfactories, is attended with serious dangers, as is also the habit of eating food in such apartments or drinking water that has been standing in them. The possibility of lead-poisoning by way of the respiratory tract has been questioned. In view of existing knowledge as to the readiness with which carbon in minute states of subdivision finds its way into the connective lymph-channels of the lung, there can be no doubt that the habitual respiration of an atmosphere loaded with the dust of lead or its preparations in a minute state of subdivision may give rise to chronic lead-poisoning. At the same time, the experiments of Hassel4 render it probable that less absorption takes place directly by means of the pulmonary mucous membrane than by way of the mucous membrane of the mouth and throat. It must be borne in mind that none of the preparations of lead are volatile. This affection is also occasionally observed in clowns and others upon the stage or elsewhere, who habitually use cosmetics containing lead. The use of cheap tinfoil, into the composition of which lead enters largely, as a wrapper for tobacco

and snuff is said to occasionally produce chronic lead-poisoning. It is stated by Naunyn that mattresses filled with horse-hair died black by lead compounds have occasioned this affection. The same authority states that a proof-reader was poisoned by reading printed proof for many years. Chronic lead-poisoning is pre-eminently a disease of the industrial arts. The means of obviating or diminishing the dangers of those exposed by their occupation to the preparations of lead will be considered under the head of Prophylaxis. The quantity of lead absorbed is of less importance than is its continuous introduction. As stated in the definition, the phenomena of chronic lead-poisoning are those brought about by the gradual accumulation of lead in the system, the amount absorbed into the blood in any given cases being comparatively small, even where large quantities are ingested. Hence prolonged exposure to small amounts of lead is attended with greater danger than a comparatively brief exposure to larger quantities. It is stated that the members of the household of Louis Philippe at Claremont manifested the symptoms of chronic lead-poisoning after the lapse of seven months in consequence of drinking water which contained a mere trace of lead. On the other hand, several grains of acetate of lead may often be administered medicinally to patients for a week at a time without inducing the phenomena of this affection, although, in view of the idiosyncrasy of many individuals, the exhibition of lead preparations for prolonged periods is not advisable.

4 The Inhalation Treatment of the Diseases of the Organs of Respiration, including

Consumption, London, 1885.

According to Heubel,5 the blood and internal organs contain but very small amounts of lead—.02 per cent. in the maximum. It is probable, therefore, that the more insoluble of the lead compounds may yield a sufficient amount of absorbable lead to produce the characteristic constitutional effects.

5 Pathogenese und Symptome der Chronic Bleivergiftung, Berlin, 1871.

So long as the urine remains free from albumen, it serves for the elimination of a mere trace of lead. In albuminous urine the amount

is larger. Lead is found in the bile and feces in small quantities.

SYMPTOMATOLOGY.—The general description of chronic leadpoisoning must include a great number of symptoms that do not always occur in regular order or sequence. According to the prominence of certain of these symptoms in particular cases the specific effects of lead may be grouped under the following five heads: (1) disturbances of nutrition; (2) the colic; (3) the arthralgia; (4) the paralysis; and (5) lead encephalopathy.

1. Disturbances of Nutrition—After the long-continued introduction of lead into the system the signs of impaired nutrition manifest themselves in almost all cases. The appearance of the patient is changed; he becomes thin, anæmic, and of a somewhat peculiar yellowish complexion. This hue of the skin, to which the term icterus saturninus has been applied, is not due to the deposition of bilepigments. The wasting of the tissues of the body seems to implicate the muscular to a much greater extent than the adipose tissues. In the majority of cases a dark or bluish-black line is observed at the border of the gums. This line is more strongly marked in the upper than in the lower jaw. It is, as a rule, more plainly developed in persons of careless habits, whose teeth are the seat of deposits of tartar, but the teeth in such individuals are often discolored and appear to be elongated in consequence of the retraction of the edge of the gums. This bluish or violet-black gingival line is due to the deposit of particles of sulphide of lead in the substance of the gum, in consequence of the reaction between the sulphuretted hydrogen formed by the decomposition of particles of food and the lead particles present in the mouth. According to Tanquerel, this color may extend over the greater part of the gum or even to the mucous membrane of other portions of the mouth. If due care be exercised, there is little danger of confounding the lead-line with the livid border of the gums frequently seen in people whose teeth are in bad condition. The occasional absence of this line in otherwise wellcharacterized cases of chronic lead-poisoning is to be noted. It does not occur when the teeth have been lost, and is slight if they are kept clean.

Patients complain of habitual dryness of the mouth and of an insipid, mildly astringent, sweetish, or faintly metallic taste; the tongue is coated, the breath fetid. There are nausea and occasional vomiting.

Constipation is common. The patient is now liable to attacks of lead colic, joint trouble, and the specific palsy, or to cerebral disturbances of grave character. Of these affections, colic is the most frequent; the joint affection is next in order; the paralysis far less common, and the cerebral disturbances comparatively rare. Continued exposure results after a time in an intensification of the malnutrition, either with repeated attacks of colic or the other specific disturbances, or occasionally in their absence, although at length the positive lead dyscrasia is established, characterized by obstinate dyspepsia, constipation, and intensification of the curious earthy or yellowish color of the skin, which is succeeded by the pallor of profound anæmia. Loss of muscular power with transient œdema now shows itself. The patient becomes apathetic, irritable, and morose. As the condition of cachexia deepens muscular tremor occasionally shows itself. After a prolonged period of profound ill-health the patient succumbs to some complication, among the more frequent of which are tuberculosis, pneumonia, and chronic interstitial nephritis. Gout is a very common complication of chronic lead-poisoning.

2. Lead Colic; Colica saturnina; Colique de plomb; Bleikolik.—This affection is also known as painter's colic, Devonshire colic, colica pictonum, the last term being derived from Poitou. It occasionally develops abruptly without previous symptoms. In the majority of cases, however, the earlier disturbances of nutrition before pointed out precede the attacks, often by a period of weeks or months. An increased tendency to constipation with transient recurrent abdominal pains, occurring sometimes immediately after food, more frequently at irregular intervals, often characterizes the prodromic period. There is, moreover, an intensification of the other symptoms of chronic lead-poisoning. The appetite is decidedly impaired, so also are the powers of digestion; the foul condition of the mouth becomes more annoying, and the peculiar taste alluded to more persistent and more marked. Constipation occasionally alternates with diarrhœa. The colicky pains which constitute the attack are of

variable intensity, but usually severe. They are of the nature of true colic. Pressure over the seat of pain almost invariably gives relief, particularly in severe attacks. During the remission pressure is grateful to the patient. The position of the pain varies. Its most common seat is in the region of the umbilicus. It may occupy the epigastric and hypochondriac regions or the lower part of the abdomen, extending from side to side above the level of the pubic bone. These colics are of some minutes' duration, recurring after short intervals, which are characterized by a certain amount of continuous cramp. Tenesmus is frequent. It may be accompanied by strangury or retention of urine, with pain in the course of the ureters, the spermatic cord, or in the penis. Shooting pains in the breast also occur. The abdomen is retracted, and scaphoid to such an extent in some instances that the prominence caused by the bodies of the vertebræ is apparent in the median line of the abdomen. It occasionally happens, however, that retraction does not occur, the belly, on the other hand, remaining prominent. As a rule, to which there are few exceptions, the bowels are constipated. This condition is often stubborn. In rare cases, however, the colic is accompanied by diarrhœa. Nausea is of common occurrence. Vomiting is sometimes violent and distressing, being ushered in by repeated attacks of retching. The vomited matters are usually discolored by bile, and icterus of slight degree usually occurs. The pulse is invariably diminished in frequency, sometimes as low as 40 or even 30, per minute. It is at the same time full and tense. The pulsefrequency is occasionally variable within comparatively brief periods of time. Respiration is increased in frequency during the attack. The urine is small in quantity and of high specific gravity, and frequently contains small amounts of albumen. It is sometimes entirely suppressed. Fever is absent, and the slight increase of temperature occasionally observed is attributable to the restlessness of the patient. The intellectual condition usually remains clear, but in violent cases it is characterized by excitement. The paroxysms of pain are more severe in the latter part of the day and during the night. The course of the attack is irregular. Relapses, which may occur in the course of some days or even weeks, are frequent. The duration of the attack does not, as a rule, exceed a week, but the illness is often

protracted by repeated relapses, and in continued exposure to the cause the tendency to colic may become chronic. The termination of the attack is in most instances as abrupt as its onset, and with the cessation of the colic the associated symptoms, such as retraction of the abdomen, constipation, vomiting, and diminished frequency of the pulse, rapidly subside. Lead colic is not unfrequently associated with the other affections of chronic lead-poisoning. The prognosis is favorable, the mortality being about 2 per cent.

3. The Arthralgia; Arthralgia saturnina.—The tissues entering into the formation of the joints and the muscular masses contiguous to them are frequently the seat of intense paroxysmal pains, which appear more or less suddenly, either with or without prodromes, and run a course similar to that of lead colic, exhibiting violent exacerbations and occasional more or less complete remissions. These pains are accompanied by painful contractions of the muscles. They are somewhat relieved by pressure and friction and aggravated by exercise and exposure to cold. Swelling and redness over the affected joints, ligaments, and tendons are absent. These pains do not follow the course and distribution of the nerve-trunks, and lack the tender pressure-points of true neuralgias. They are more common in the lower extremities, the knee being especially apt to be affected. When they affect the upper extremity the elbow and shoulder suffer more frequently than the other joints. The flexor muscles are much more frequently attacked than the extensors. The muscles of the back, especially the great masses of long muscles in the lumbar region, whose function is to sustain the equilibrium of the body, are frequently implicated. The intercostal muscles and the muscles of the neck are also frequently affected. The small joints and the muscles of the hands and feet as a rule escape. The pain is tearing and burning in character, and very often severe. It is occasionally associated with tremor. The derangement of the alimentary canal, especially constipation, which is so characteristic of lead colic, is often absent. Fever does not occur.

A careful study of these cases establishes the fact that in a considerable proportion of them the morbid condition is myalgic.

Whether it be due to simple muscular malnutrition or to some specific action of lead upon the muscle-substance is not determined.

The analogy between these muscular pains and lead colic renders it probable that in a large majority of the cases the latter view is correct. These pains are frequently associated with the attack of lead colic; sometimes, however, they precede the colic, while at other times they follow it. After a series of remissions and exacerbations the pain often ceases as suddenly as it began. As in other lead affections, relapses are frequent. The prognosis is favorable.

The English physicians, and especially Garrod,6 Todd,7 and Bence Jones,8 have insisted upon the frequency of gout in chronic leadpoisoning. Murchison,9 Wilks,10 and others regard this association as causative. This view has not found general acceptance in France.

Lancereaux11 in particular, after a comparative study of the lesions of the kidney and of the joints in saturnine cachexia and the corresponding lesion of gout, concludes that the gouty kidney and the kidney of lead-poisoning have the same appearance, and are simply varieties of interstitial nephritis, and that the articular and arterial lesions in both affections are identical. So-called saturnine gout differs in no respect, either in its clinical or anatomical characters, from ordinary gout. It would therefore appear superfluous to describe saturnine gout. At the same time, it must be insisted upon that chronic lead-poisoning exercises an important influence in the production of gout—a causal relation due to the fact that lead diminishes the excretion of uric acid.

6 Medico-Chirurg. Transactions, 1854, vol. lvi.

7 Clinical Lectures, London, 1856.

8 Transactions of the Pathological Society, London, 1856.

9 Lancet, 1868.

10 British Medical Journal, 1875.