2015 Annual Report by Women & Infants Hospital of Rhode Island

2015 Annual Report

Department of Obstetrics & Gynecology

The Choice For the Advances of Health Care for Women

Our Commit ment “Make no mistake — it is never about the recognition; it is always about the quality of care.” — Maureen G. Phipps, MD, MPH Chair, Department of Obstetrics & Gynecology

CONTENTS Message from the Chief. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2

Urogynecology and Reconstructive Pelvic Surgery. . . . . . . . 22

Ambulatory Care. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Minimally-Invasive Surgery and Surgical Services. . . . . . . . . 24

Emergency Obstetrics & Gynecology . . . . . . . . . . . . . . . . . . . 6

Simulation Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26

Gynecologic Oncology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Inpatient Obstetrics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27

Gynecologic Oncology â&#x20AC;&#x201C; Breast Health. . . . . . . . . . . . . . . . . 10

Community-Based Physicians. . . . . . . . . . . . . . . . . . . . . . . . 30

Maternal-Fetal Medicine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Department Listing. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34

Medical Education . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

Grant Funding. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38

Midwifery Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

Peer-Reviewed Publications. . . . . . . . . . . . . . . . . . . . . . . . . . 44

Reproductive Endocrinology and Infertility. . . . . . . . . . . . . . . 18

Editorial Positions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56

Clinical Research in Womenâ&#x20AC;&#x2122;s Health. . . . . . . . . . . . . . . . . . . 20

Contacts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57

2015 Annual Report

Message from the Chief “I chose to come here because I wanted to get the best training I could get.” — Jonny Shaw, MD, fellow, Division of Urogynecology and Reconstructive Pelvic Surgery

Providers choose to come here to practice medicine – from our most senior faculty who are at the top in their fields and still innovating, teaching, providing incomparable care; to our mid-career faculty who have found a program that offers them the opportunity for clinical growth, an environment that supports creativity and a commitment to academic advancement; to our young, emerging leaders who have discovered a challenging and supportive environment that has enabled them to launch their careers. “I chose to come to Brown and Women & Infants in 1982 because the med school was quite young and the department had really just begun as a separate entity. I believed that there was the potential for building something outstanding. I have never been disappointed in my decision to move here, and I am very proud of the faculty, the facility and the infrastructure that developed.”

Over the years, it has become very clear to me that people consciously choose to come to the Department of Obstetrics & Gynecology at Women & Infants Hospital of Rhode Island and The Warren Alpert Medical School of Brown University. Students and trainees choose to come here to learn – for medical school, residency and specialized fellowship training. Our residents and fellows have the opportunity to learn from the leaders in the field, giving them a strong foothold to becoming leaders themselves. Undoubtedly, our trainees appreciate that they are learning from the best in an environment that offers first-rate clinical experiences coupled with an outstanding educational experience. 2

— Donald R. Coustan, MD, Division of Maternal-Fetal Medicine

Researchers choose to come here for opportunities to discover – in such areas as unexpected complications of low-risk pregnancy, abnormal uterine bleeding, achieving greater intimacy with conservation therapy for breast cancer treatment, preventing postpartum depression in vulnerable populations, novel combinations for the treatment of women’s cancers, optimizing weight gain in pregnancy, addressing the cost of care, risk analysis for obstetrical hemorrhage, preimplantation genetics, treating stress urinary incontinence at the same time as treating a woman with endometrial cancer, and improving health outcomes for women and their children.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

“I came to Women & Infants 11 years ago because it offered great opportunities for training women’s reproductive health investigators capable of interdisciplinary research aimed at improving maternal-child health and women’s reproductive health outcomes.” — Kristen Matteson, MD, MPH, Division of Clinical Research in Women’s Health

And of course patients choose to come here for their health care – from high risk and low risk pregnancies, to management for pelvic floor disorders, to evaluation and treatment for breast and gynecologic cancers, to some of the most advanced gynecologic surgery – because of the quality, state-of-the-art care. Quality is the cornerstone of what we do at Women & Infants. It’s why we were recognized by The Joint Commission as a Top Performer on Key Quality Measures® for 2015. And it’s why in 2015, after years of dedication to improving the maternity care services that improve breastfeeding, Women & Infants was delighted to announce that we have been designated a Baby-Friendly® USA Hospital – the second largest hospital in the U.S. to achieve this designation. But make no mistake – it is never about the recognition; it is always about the quality of care.

“I tell my patients all the time that I am the physician I am, in large part, because of the team at Women & Infants. The physicians (colleagues and residents), nurses, secretaries, lab personnel, radiology personnel, security staff, culinary staff and medical records staff who have worked with me for 33 years help me give my patients the best possible care. We work well together and focus on the patient. The relationship between the hospital-based and communitybased physicians is unparalleled. I believe that this benefits the patients because they are able to maintain continuity with their community-based physician while benefiting from the expertise of our subspecialists.” — Kathleen Cote Bowling, MD, Bayside Ob/Gyn, Women & Infants Health Care Alliance

We have created an environment in which we are supportive of each other – we are truly proud of each other, we lift each other up, we work as a team. So it is in the Department of Obstetrics & Gynecology at The Warren Alpert Medical School of Brown University and at Care New England’s Women & Infants Hospital of Rhode Island. And I am proud to present our 2015 annual report.

Maureen G. Phipps, MD, MPH Chair and Chace-Joukowsky Professor of Obstetrics & Gynecology Assistant Dean for Teaching and Research in Women’s Health Warren Alpert Medical School of Brown University Professor of Epidemiology Brown University School of Public Health Chief of Obstetrics & Gynecology Women & Infants Hospital of Rhode Island Care New England 2015 Annual Report

Ambulatory Care The mission of the Women’s Primary Care Center: We provide comprehensive obstetric and gynecologic services, education and research, and promote the health of our community through a multidisciplinary team that offers individualized state-of-the-art care in a culturally diverse setting.

ACHIEVEMENTS • Providers in the WPCC cared for 1,129 new obstetric patients and 12,736 gynecologic patients, performed 443 colposcopic exams, inserted 496 intrauterine devices and 278 contraceptive implants, and administered 1,780 vaccines in 2015.

EXPERTISE The faculty in the Division of Ambulatory Care is responsible for the administration, teaching and clinical care coordinated in the Women’s Primary Care Center (WPCC). In 2015, the WPCC continued to deliver comprehensive obstetric and gynecologic services to a large and diverse population, including a large percentage of patients who are underinsured and/or medically underserved. The WPCC registered 27,661 patient encounters which included visits through general obstetrics and gynecology continuity clinics, Women’s Dysplasia Program (formerly Colposcopy Clinic), Pelvic Pain Program, Menopause Program, Complex Contraceptive Counseling and Provision, Early Options, Infectious Disease, Pediatric Gynecology, Reproductive Endocrinology, Surgical Evaluation, Urogynecology, and Vulvar Care clinics.

• Renee Eger, MD, was named the new medical director of the WPCC and the director of the Menopause Program at Women & Infants Hospital. She serves as an examiner for the American Board of Obstetrics and Gynecology. • Rebecca Allen, MD, MPH, was invited to participate in updating U.S. national guidelines on the Medical Eligibility Criteria for Contraceptive Use and Selected Practice Recommendations for Contraceptive Use at the Centers for Disease Control and Prevention. Dr. Allen directs family planning services at the WPCC. • Dr. Allen was also ranked in the top 10 percent among reviewers in 2014 for the professional journal, Obstetrics and Gynecology. • Beth Cronin, MD, was accepted into the Association of Professors of Gynecology and Obstetrics (APGO) Scholars and Leaders Program for the upcoming year. Dr. Cronin is the new co-director of the Women’s Dysplasia Program as well as the director of the Pelvic Pain Program.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I chose to come to Women & Infants Hospital because of the comprehensive educational opportunities it offered. Residents were actively and directly involved with patient care. Women & Infants Hospital was and is the premier hospital for women in Rhode Island and southeastern Massachusetts. I chose to stay at Women & Infants because I learned during my residency what exemplary care we deliver. I wanted to be at a place where I myself would go. I wanted my patients to be cared for by people who I knew would provide state-ofthe-art care delivered with compassion.” — Renee Eger, MD, Division of Ambulatory Care

MEDICAL DIRECTOR: Renee Eger, MD Front row: Erin Dobson, RNP; Darcy Renagan, MSN, WHNI-BC; Renee Eger, MD; Anne Stulik, RNP. Back row: Ann Holdredge, CNM, NP; Ann Cooper, RNP; Beth Cronin, MD; Rebecca Crichton, MD; Rebecca Allen, MD; Patricia O’Connell, RNP

THE MENOPAUSE PROGRAM AT WOMEN & INFANTS HOSPITAL The Department of Obstetrics & Gynecology is committed to providing services to women at all ages and stages of their lives. And while the department faculty has always offered programs to menopausal women, this year Women & Infants Hospital introduced the Menopause Program, a multidisciplinary and complementary program for women at midlife. Many women focus on symptoms of menopause that they can feel or experience. These include vasomotor symptoms such as hot flashes and night sweats; vulvovaginal problems such as vaginal dryness, pain, burning and painful intercourse; and mood changes such as depression, anxiety and diminished libido. Other aspects of menopause are “silent” but can pose significant risk for women at midlife and beyond. These include cardiac disease, bone loss and increased risk of certain cancers in women as they age. The Menopause Program represents a coordination of care between gynecology, cardiology, endocrinology, and behavioral health, meeting the diverse needs of menopausal women while focusing on individualized care.

Providers in the Menopause Program: • Renee Eger, MD Program Director

• Ruben Alvero, MD Reproductive Endocrinology and Infertility

• Carol Wheeler, MD Reproductive Endocrinology and Infertility

• Ken Chen, MD Internal Medicine/Endocrinology

• Alice Kim, MD Cardiology

• Heather Hurlbert, MD Cardiology

• Jessica Pineda, MD Internal Medicine/Psychiatry

• Laura Chalk, PCNS Women’s Behavioral Health 2015 Annual Report

Emergency Obstetrics & Gynecology ACHIEVEMENTS The Emergency Unit patient care team includes 50 staff nurses, 10 board certified specialists in general obstetrics and gynecology, five certified nurse midwives, three nurse practitioners, residents in obstetrics and gynecology and emergency medicine, medical students and other trainees. • Women & Infants Hospital was designated by the Centers for Disease Control and Prevention as a Special Pathogen Assessment Center in November 2015.

EXPERTISE The Women & Infants Emergency Obstetrics & Gynecology Unit is one of two primary clinical sites for Women & Infants hospital-based specialists in general obstetrics and gynecology. The specialty emergency room provides care to women of all ages presenting with acute obstetric, benign gynecologic and cancer-related issues. The Emergency Department is the primary entry point for the majority of patients who access Women & Infants Hospital for care, and the volume for fiscal year 2015 was just under 30,000 visits. Women & Infants is the primary referral and treatment site for female victims of sexual assault and maintains the only comprehensive Sexual Assault Nurse Examiner (SANE) Program in Rhode Island. As a leader in this area, the Emergency Department staff was invited to join the Sexual Assault Task Force for the state of Rhode Island alongside other stakeholders including the Governor’s office, Day One, local colleges, the Department of Elderly Affairs, law enforcement, the Attorney General’s office, and the state laboratory. A primary charge of this task force is to address the critical need to create a consistent and standardized means for tracking sexual assault data in Rhode Island. 6

• Roxanne Vrees, MD, was part of a team that presented at the Annual Clinical meeting of the American College of Obstetricians and Gynecologists (ACOG), “Teaming Up for Women’s Health.” Her presentation was entitled “The Effect of Topical Lidocaine on Pain During Manual Vacuum Aspiration for Nonviable Pregnancies.” • Women & Infants’ Emergency Department is the only one in New England to be named to Becker’s list of “52 hospitals with the shortest ED wait times before admission,” with an average door-to-doctor time of 30 minutes. • Women & Infants is an integral part of a Sexual Assault Task Force that was launched in May 2015. The goals of the task force are to: • Establish a statewide, comprehensive and collaborative multidisciplinary, team-based approach to the evaluation and management of adult victims of sexual assault; • Develop and implement policies and protocols utilizing a best practice approach with emphasis on forensic investigation and prosecution; • Improve the response rate to sexual assault victims in urgent need of services; and • Ensure that an efficient sexual assault response team is accessible to all victims.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“My reasons for choosing Brown/Women & Infants are the sense of community (i.e. the Women & Infants family), academic excellence, teaching and mentorship.” — Roxanne Vrees, Division of Emergency Obstetrics and Gynecology

MEDICAL DIRECTOR: Roxanne Vrees, MD

Front row: Amy Snyder, MD; Roxanne Vrees, MD; E. Christine Brousseau, MD; Chelsy Caren, MD; Kate Zaluski, MD Back row: Beth Cronin, MD; Michael Sisitsky, MD; Mohamad Hamdi, MD

PREPARING FOR THE EBOLA THREAT In order to ensure that health care providers and facilities in the United States are prepared to safely identify, isolate, treat and transport patients with Ebola or other emerging pathogens, the U.S. Department of Health and Human Services recently launched a National Ebola Training and Education Center (NETEC). Nine regional Ebola treatment centers have been identified and are part of a special network of 55 total treatment centers. Women & Infants Hospital has been designated as one of two (state and federally selected) Special Pathogens Assessment Hospitals for the state of Rhode Island. With this designation, Women & Infants’ Emergency Care team will work collaboratively with Care New England medicine and infectious disease specialists to partner with the Rhode Island Department of Health and Rhode Island Hospital to receive, identify, assess, stabilize and provide initial care for perinatal/neonatal patients with suspected/confirmed Ebola or other special or emerging pathogens. As an assessment hospital, Women & Infants will

have the capability to evaluate and care for individuals who have a travel history and symptoms compatible with Ebola for up to 96 hours and initiate or coordinate Ebola testing as well as testing for alternative diagnoses until arrangements are made to transfer to a designated facility. As a part of the comprehensive preparedness training program, providers in the Emergency Obstetrics & Gynecology Unit are attending educational programs hosted by NETEC. Cornerstones of the training program will include development of department specific policies, patient care protocols and monitoring mechanisms for health care workers and patients suspected to have a seriously communicable disease. As a Special Pathogen Assessment Hospital, Women & Infants will continue to be a local and national leader in emergency obstetrics and gynecology.

2015 Annual Report

Gynecologic Oncology ACHIEVEMENTS • The program’s national reputation is reflected by international media’s solicitation of its expertise, two examples of which are: • National Public Radio’s “All Things Considered” radio show featured a story on a patient and her caregivers, including Elizabeth Ricci, RNP, MS from the Program in Women’s Oncology at Women & Infants Hospital. The story, which aired nationwide in March, featured an interview with an ovarian cancer patient who sought treatment at the Program in Women’s Oncology.

EXPERTISE The Division of Gynecologic Oncology and its Breast Health Center, collectively known as the Program in Women’s Oncology, has created a very special, unique and caring environment. This program continues to provide the best possible care for women with cancer, and their families, with a true dedication and compassion, always asking, “Can we do more?” and “What would you want done for your loved one?”. The Program in Women’s Oncology has, as its foundation, a unique philosophy and core values that focus on a multidisciplinary, prospective and patient-centered care team approach. An integral part of the Program in Women’s Oncology is its all-encompassing tumor board process. Following their first visit, each patient’s case is presented to the multidisciplinary tumor board. Ultimately, this group of experts formulates treatment recommendations. The Program in Women’s Oncology is also dedicated to research and education. It is actively engaged in basic science and clinical trials, as well as teaching at all levels, including its fellowships in gynecologic oncology and breast disease. And finally, in addition to the science of medicine, the program is committed to “art in medicine” and how it improves spirit and the moment for everyone, patients and providers among them. 8

• Rhode Island mandated the HPV vaccine for all school children, along with their other school required vaccines in seventh grade. Katina Robison, MD, was invited by the Rhode Island Department of Health to sit on a panel to discuss this mandate with the community. Dr. Robison then interviewed with multiple local radio stations and newspapers, including the Boston Globe and WPRO-AM radio. Dr. Robison was also interviewed by Al Jazeera America for one of their media segments. •

The program, including Gynecologic Oncology and the Breast Health Center, as well as its physicians are regularly selected among the best in the nation by different organizations, including Newsweek, Rhode Island Monthly magazine, Best Doctors in America, Top Cancer Doctors, and the American College of Obstetrics and Gynecology.

• C.O. (Skip) Granai III, MD, was the Presidential Speaker at the American Congress of Obstetricians and Gynecologists (ACOG) Annual Clinical and Scientific Meeting. • Ashley Stuckey, MD, was the invited speaker at the “Bring Back Breast Care to the OB-GYN” at the ACOG Annual Clinical and Scientific Meeting. •

Cara Mathews, MD, earned the Gynecologic Oncology Group Foundation’s national Young Investigator Award for 2015 for her research presentation, “Survival in advanced endometrial cancer: Does time to chemotherapy initiation matter?”

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Paul DiSilvestro, MD, is co-chair of both the Ovarian Cancer Committee and the Breast Cancer Committee of NRG Oncology. He was also recently appointed to a task force involving the SGO, FDA and NRG oncology developing a guidance document for neoadjuvant ovarian cancer treatment and accelerated drug approval.

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The Program in Women’s Oncology began a Women’s Intimacy and Sexual Health (WISH) Clinic. The clinic is led by Dr. Katina Robison; Dr. Jennifer Gass; Dr. Tina Rizack; nurse practitioner Elizabeth Ricci, RNP, MS; and clinical social worker Dana D’Alessandro Haseotes.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I have thought about why I chose to come to Women & Infants many times and am often asked this by applicants for medical school, residency and fellowship. As a native Californian, I never thought I would end up in RI, but the minute I interviewed for residency at Women & Infants, I knew it was where I wanted to be and then where I had to stay! The combination of world renowned physicians and a warm, ‘homey’ feel was not like anywhere I had ever been. I have stayed because it truly is my home, but I have a family that is helping me build a career I never thought imaginable. I am supported clinically, medically and personally. It is a special place.” — Katina Robison, MD Division of Gynecologic Oncology

DIVISION DIRECTOR: C.O. (Skip) Granai III, MD

Ashley Stuckey, MD; C.O. Granai, MD; Paul DiSilvestro, MD; Cara Mathews, MD; Katina Robison, MD

RESEARCH PROGRAM IN WOMEN’S ONCOLOGY The Research Program in Women’s Oncology at Women & Infants Hospital is a nationally recognized leader in gynecologic and breast cancer clinical trials. The fundamental mission of the program is to provide patients with the latest in treatment options and access to research on prevention, screening, survivorship, and quality of life for those women affected by gynecologic or breast malignancies. This is done through several resources. First, and most important, is the program’s participation in NRG Oncology. NRG Oncology is a National Cancer Institute funded, multi-institutional, cooperative research group with a major focus on gynecologic and breast cancer treatment. Additional resources include direct interaction with the pharmaceutical industry with its access to many novel agents, such as immunotherapeutics, immune modifiers and targeted therapies, along with programs developed primarily here at Women & Infants Hospital. An exciting development over the past several years has been the program’s participation in the phase I program of the Gynecologic Oncology Group. Phase 1 research evaluates newly developed drugs for their safety and efficacy as well as novel combinations for cancer treatment. As the only institution in Rhode Island and the surrounding communities offering this option, Women & Infants is committed to providing this level of care to its patients. Led by Dr. Cara Mathews, Women & Infants is a leader in the number of phase 1 trials offered and participants involved. In addition to treatment trials, the Program in Women’s Oncology has gained further stature through the investigation of survivorship issues relevant to its patients. One example of this is the recently approved study led by Dr. Katina Robison through the National Patient Care Outcomes Research (PCORI) mechanism, funded by the National Institutes of Health, evaluating urinary tract health in women affected by uterine cancer. This project showcases collaboration between several of the divisions within Women & Infants Hospital as well as other institutions regionally and nationally. 2015 Annual Report

Gynecologic Oncology – Breast Health ACHIEVEMENTS

EXPERTISE Within the Breast Health Center, a cornerstone of the Program in Women’s Oncology, surgical oncologists, gynecologic oncologists, medical oncologists, radiation oncologists, genetic counselors, nurse practitioners, nurses, social workers and dietitians work literally side by side in a true interdisciplinary model to provide state-of-theart care for women with both benign and malignant breast disease. After initial evaluation, all cases are prospectively presented at a multidisciplinary tumor board. This process, which takes place weekly, allows multiple experts to review all patient data and discuss and decide, together, the best plan for treatment. Accredited by the Society of Surgical Oncologists (SSO) and the National Accreditation Program for Breast Centers (NAPBC), the Breast Health Center is a local and national research leader, advancing knowledge on the causes of and treatment for breast cancer. Understanding and embracing the responsibility to train the next generation of health care providers, the Breast Health Center is one of just a few centers nationally which offers an SSO accredited breast disease fellowship. The faculty also provide daily training of medical students, residents, and medical and gynecologic oncology fellows through formal programs and electives within The Warren Alpert Medical School of Brown University. Physicians with an interest in breast disease from around the country and around the world also visit the center. 10

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As acknowledgement of its dedication to providing exceptional patient care and treatment for women with breast disease, The Breast Health Center has earned a 2015 Women’s Choice Award®, making it one of America’s best breast centers.

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David Edmonson, MD, has helped pioneer the use of a threedimensional device that is placed in the breast during a lumpectomy which identifies in a fixed, 3D manner where the tumor was removed from the breast, helping the radiation oncologist refine treatment. This technique may help increase the ability for some women to choose breast conservation over mastectomy and may significantly aid in cosmesis.

• Jennifer Gass, MD, now president of the National Consortium of Breast Centers (NCBC), served as program chair for the organization’s national meeting. • Leaders within Women & Infants Cancer Genetics and Prevention Program, Jennifer Scalia Wilbur, MS and Jessica Laprise, MS co-directed the NCBC’s post genetics conference entitled, “The New Era of Breast Cancer Risk Assessment and Genetic Testing: Building and Incorporating the Latest Data into Your High-Risk Clinic.” •

William Sikov, MD, presented data on a subtype of aggressive breast cancer entitled, “Event-free and overall survival following neoadjuvant weekly paclitaxel and dose-dense AC +/- carboplatin and/or bevacizumab in triple-negative breast cancer: Outcomes from CALGB 40603 (Alliance)” at the San Antonio Breast Cancer Symposium. Dr. Sikov led this national research study as part of a large group of investigators across the country.

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The Women & Infants clinical research program has greatly expanded this year and offers the most in-depth clinical research opportunities in the region for breast cancer treatment. The program currently offers clinical trials focusing on innovative therapies for locally advanced breast cancer administered before surgery such as chemotherapy, biologic therapy and endocrine therapy, as well as research trials focusing on optimizing the treatment of breast cancer which arises in individuals whose tumors harbor a genetic mutation, such as in BRCA1 or BRCA2.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“After nearly two decades, I choose to practice medicine as an oncologist/hematologist at Women & Infants Hospital, an institution which shuns mediocrity and is always striving to improve the lives of our patients and the wellbeing of our community. In an ever challenging health care environment, I am proud that Women & Infants stands firmly committed to clinical and basic research, translating scientific insight into more effective therapy for human disease. As a teaching institution, Women & Infants enriches my vocation through the opportunity to teach younger physicians, other health care providers and students on a daily basis. Within the Program in Women’s Oncology, founded and focused on core values, I am honored and extremely fortunate to work with an utterly amazing group of colleagues and staff dedicated to the holistic approach to the treatment and prevention of cancer.” — Robert D. Legare, MD Breast Health Center

CO-DIRECTOR: Jennifer Gass, MD

CO-DIRECTOR: Robert Legare, MD

Front row: Ashley Stuckey, MD; David Edmonson, MD; Jennifer Gass, MD; Tina Rizack, MD; Robert Legare, MD Back row: Sabrina Witherby, MD; William Sikov, MD; Bachir Sakr, MD; Steven Cohen, MD (Missing from photo: Sonali Pandya, MD and Rebecca Vanasse, MD)

TOWARD A SYSTEM-WIDE INTEGRATION OF BREAST CANCER CARE AND RESEARCH The Breast Health Center at Women & Infants Hospital, a local and national leader in breast cancer care and research, has been asked to create and lead a breast health service line across the hospital’s parent Care New England. Led by Robert D. Legare, MD, and Jennifer Gass, MD, and working with colleagues at Care New England’s Kent and Memorial hospitals, this year saw the establishment of a system-wide, multidisciplinary tumor board, at which all cases of invasive and pre-invasive breast disease from each institution are presented weekly using teleconferencing technology. This process allows a wider scope of opinion around each case as the team reviews, together, each patient’s history, radiology and pathology. As part of this collaborative, the Breast Health Center at Kent, with Candace Dyer, MD; Bachir Sakr, MD; and Ashley Stuckey, MD, has increasingly been able to serve the Kent County community. Having established the Breast Health Center at Kent, plans are now underway to similarly develop a vibrant breast health center program in collaboration with the physicians and caregivers at Memorial Hospital. To that end, “visiting physicians” from Memorial Hospital, such as Sabrina Witherby, MD, are working at the Women & Infants’ Breast Health Center. Genetic counselors are also providing consultative services both at Kent and Memorial hospitals, as part of the Cancer Genetics and Prevention Program. 2015 Annual Report

Maternal-Fetal Medicine ACHIEVEMENTS • Erika Werner, MD, MS, was chosen to be one of six Hassenfeld Faculty Scholars in the newly established Hassenfield Child Health Innovation Institute. Dr. Werner also received a grant from the American Diabetes Association’s Research Program, entitled “Assessing and avoiding barriers to postpartum glucose testing among women with gestational diabetes mellitus.” • Brenna Hughes, MD, MSc, served as chair or participated in three special emphasis panels for the CDC and NIAID and was an invited participant in the NICHD chorioamnionitis workshop. Dr. Hughes was appointed to ACOG’s Immunization Expert Work Group (IEWG) and was invited to be an examiner for the maternal-fetal medicine oral board exam.

EXPERTISE The Division of Maternal-Fetal Medicine is a team of nine faculty members and three fellows who serve both as consultants and as primary obstetric providers for women with a wide range of chronic medical conditions, obstetric complications, and fetal abnormalities. The maternal-fetal medicine specialists not only provide the full range of prenatal diagnosis and pregnancy monitoring services, but are also dedicated to taking care of vulnerable high-risk women in the hospital - truly keeping the “M” in maternal-fetal medicine. The division’s goal is to provide the most up-to-date, evidencebased medical, obstetrical and surgical care; to conduct high quality research on clinical problems in obstetrics and how to optimize outcomes for both mother and fetus; and to train medical students, residents and fellows to provide excellent clinical care and conduct valuable research in the specialty. The Division provides clinical services through the MaternalFetal Medicine Clinic and the Prenatal Diagnosis Center, which provides specialized services and testing, comprehensive screening, fetal assessment and genetic counseling. The division also participates in Women & Infants’ Integrated Program for High-Risk Pregnancy, working collaboratively with the hospital’s Division of Obstetric and Consultative Medicine. 12

• Tanya Booker, MD, chaired the RI Department of Health’s Commission for Health Advocacy and Equity, and served on the RI Preconception Health Strategic Plan Steering Committee. • Katharine Wenstrom, MD, was co-director of a course on noninvasive prenatal testing at the ACOG annual meeting, and was keynote speaker at the annual Lamaze International Annual Conference, the CDC’s National Birth Defects Prevention Network Annual Meeting, and the annual meeting of the Maryland Perinatal Safety Center/Perinatal-Neonatal Learning Network. • Matthew Esposito, MD, was a featured speaker at the inaugural Women & Infants’ Alumni Weekend Symposium. • Dwight Rouse, MD, was the invited speaker for the Massachusetts General Grand Rounds Clinical Pathologic Conference on the topic, “A 31-year-old pregnant woman with fever and cholestasis,” which will be published in the New England Journal of Medicine as “Case Records of the Massachusetts General Hospital.” • Stephen Carr, MD, serves the State Air Surgeon, Rhode Island Air National Guard, and advises the Assistant Adjutant General for Air on all aspects of medical capabilities and responses for Rhode Island Air National Guard medical assets. • Donald Coustan, MD, gave the Madras Diabetes Research Foundation Gold Medal Oration, “Gestational diabetes mellitus: The need for international consensus,” at the International Update on Gestational Diabetes Mellitus in Chennai, India, and was also an invited speaker at the International Symposium on Diabetes, Hypertension, Metabolic Syndrome and Pregnancy, in Berlin, Germany.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I chose to join Women & Infants Hospital because I wanted balance. I wanted to be able to care for patients, teach, do research and enjoy my life outside of the hospital walls. At Women & Infants, I found colleagues who were doing exactly this every day.” — Erika Werner, MD, Division of Maternal-Fetal Medicine

DIVISION DIRECTOR: Katharine Wenstrom, MD Erika Werner, MD; Brenna Hughes, MD; Stephen Carr, MD; Katharine Wenstrom, MD; Dwight Rouse, MD; Sarah Davis, MD; Tanya Booker, MD; Donald Coustan, MD; Matthew Esposito, MD

MATERNAL FETAL MEDICINE UNITS (MFMU) NETWORK

The NICHD Eunice Kennedy Shriver Maternal Fetal Medicine Units (MFMU) Network is a consortium of 14 premier clinical centers across the U.S. whose charge is to investigate problems in clinical obstetrics. Brown/Women & Infants Hospital of Rhode Island has been a participating center in the MFMU Network for the past three five-year cycles and is the only MFMU center in New England. The Network conducts large randomized clinical trials aimed at improving outcomes for pregnant women and their offspring. With 140,000 births spread among its 14 centers, the Network is able to perform trials of sufficient size to reach definitive conclusions that result in health-improving practice changes locally, nationally and internationally. These trials directly inform the guidelines of the American College of Obstetricians and Gynecologists and clinical obstetric practice in the U.S. and abroad. As a result of MFMU Network trials, in the U.S. it is now routine to: a) Use weekly 17-alpha hydroxyprogesterone caproate to prevent repeat preterm birth. b) Administer antibiotics to women with preterm premature rupture of membranes to improve neonatal health. c) Give women in early preterm labor magnesium sulfate to lower the chance that their baby will suffer from cerebral palsy. d) Treat mild gestational diabetes to improve maternal and neonatal health.

The two most recently completed MFMU Network studies, presented only in preliminary form, will also directly improve practice. The Antenatal Late Preterm Steroids (ALPS) study showed that betamethasone administered to mothers delivering in the late preterm period (from 34 to 36 weeks gestation) lowers the risk of respiratory problems in their babies. Of the 2,800 women in this study, 290 were enrolled at Women & Infants. The TSH study showed that treating pregnant women with subclinical hypothyroidism does not improve the intelligence of their children at age five (as had been claimed), and therefore screening pregnant women for this condition is not warranted. Ongoing Network trials include induction of labor compared to expectant management for low-risk, first-time mothers at 39 weeks of gestation, treatment of pregnant women with primary cytomegalovirus infection to prevent congenital infection of their babies (a study led by Women & Infants), and prevention of preterm birth in women with a short cervix who are carrying twins with vaginal progesterone or a cervical pessary. Currently Brown/Women & Infants is the single best recruiting hospital in the entire Network. This success is in no small part a reflection of the tremendous support of the community physicians and midwives, as, overwhelmingly, patients who participate in the MFMU trials are drawn from the practices of community providers who actively encourage their patients’ participation. 2015 Annual Report

Medical Education ACHIEVEMENTS • The Ob/Gyn Residency Program was again selected by U.S. News & World Report/Doximity as one of the top 10 Obstetrics and Gynecology Residency Programs in the country.

EXPERTISE The Division of Medical Education encompasses the Alpert Medical School’s Obstetrics and Gynecology Undergraduate Medical Education Program as well as the Graduate Medical Education Residency Program. Women & Infants houses the only obstetrics and gynecology residency training program at Brown and in Rhode Island with eight residents per year who are highly respected and recruited. Students and trainees in these programs benefit from the teaching of outstanding residents, nurse practitioners, midwives, and faculty physicians. Women & Infants is the primary teaching site for Alpert Medical School student clinical experiences in obstetrics and gynecology, hosting all third-year medical students, including students who participate in the traditional core clerkship curriculum and the longitudinal integrated clerkship curriculum. All medical student clinical learning is based on the educational objectives designated by the Association of Professors of Gynecology and Obstetrics (APGO). Didactics and hands-on workshops, including breast and pelvic exams using gynecologic teaching associates as live models as well as other simulation models, are taught by department faculty, fellows and residents. The outstanding teaching and mentoring that students receive during their clinical clerkships, as well as the hard work of the department’s unique and dedicated Undergraduate Medical Education Career Mentoring Committee, continues to inspire and support students in the pursuit of ob/gyn as a career. 14

•

Alpert Medical School medical students select six residents each year from all of the approximately 560 Brown residents for their Humanism and Excellence in Teaching Award. In the six years since this award was created, ob/gyn residents have won 11 of the 36 spots. Similarly, the Brown students vote on the two best overall teachers from all Brown residents. In the last seven years, the ob/gyn program has won five spots out of the possible 14.

•

This year residents applying for subspecialty fellowships matched into these very competitive fields, including three in gynecologic oncology, two in maternal-fetal medicine, and two in reproductive endocrinology and infertility.

• Residents’ scholarly productivity continues and includes multiple first author works, including six poster presentations, 15 oral presentations, and 14 publications with residents as first authors for 2014–15. •

The department has joined the BRIGHT Pathway (Brown Residency International/Global Health Training Pathway) to permit more global health opportunities. In addition to actual overseas rotations, the BRIGHT Pathway contains a curriculum with lectures such as advocacy, incorporating global health into one’s career.

•

Gary Frishman, MD, the program director, is in his second year of his six-year term on the Residency Review Committee of the ACGME, the credentialing body for all obstetric and gynecologic residency programs. He also continues in his role as deputy editor of the Journal of Minimally Invasive Gynecologic Surgery, serves as a board examiner for the American Board of Obstetrics and Gynecology and was recently elected secretary treasurer of the AAGL (with membership of more than 7,700 from more than 100 countries). In two years, he will be president of that society.

•

B. Star Hampton, MD, was co-director of a unique regional resident readiness course. Multiple members of the department served as faculty in this course, which was a national model and gave Alpert Medical School students a unique opportunity. Ten students successfully matched into the specialty this year.

•

Dr. Hampton, the clerkship director, served as program co-chair for the APGO Faculty Development Course and continues to serve on its Undergraduate Medical Education Committee, a 12-member national committee that produces teaching tools and promotes innovative teaching methods for continued national excellence in undergraduate medical education.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I was finishing my fellowship training, and my wife and I decided to move to this geographic area for her work. I researched the region including Boston and the surrounding area. My goal was to secure a position in an academic environment where I could not only provide outstanding patient care, but also participate in research and education. What I did not know enough to look for, at that time in my career, was superb mentoring and an outstanding and collegial department. Immediately upon starting here, I realized I had chosen correctly from a patient care and academic standpoint, but it took me some time along with talking with colleagues and peers around the country to realize my good fortune in the mentoring, department leadership and incredible cohort of colleagues that I interact with every day!” — Gary Frishman, MD Medical Education

PROGRAM DIRECTOR: Gary Frishman, MD

Rebecca Allen, MD; B. Star Hampton, MD; Roxanne Vrees, MD; Gary Frishman, MD

ALUMNI EVENT The Department of Obstetrics and Gynecology has a rich tradition of outstanding physicians who have both helped provide care to individual women and change how medicine is practiced. The experience of being a resident within this department includes learning from national leaders as well as accomplished community physicians, and the people are what make Women & Infants rich in history and accomplishment. In recognition of the people who have shaped Women & Infants/Brown history, the department celebrated its first Alumni Weekend Symposium. With structured learning centering around the subject of “The Impact of Obesity on Women’s Health,” the weekend was designed to foster idea sharing as well as networking. A welcome reception started the weekend and allowed for alumni and faculty to (re)connect. Outstanding educational talks were given by Women & Infants/Brown faculty focusing on the impact of obesity across a woman’s life, including pregnancy-related issues, pelvic floor disorders, cancer, polycystic ovary syndrome, and both medical and surgical treatment. A lunch and networking reception followed, with an evening social event closing out the hugely successful weekend. Former residents both newly graduated and seasoned physicians (dating back to the class of 1974) came from near and far (Grenada). 2015 Annual Report

Midwifery Program

Caucus, the American Midwifery Certification Board, The Journal of Midwifery and Women’s Health Editorial Board, The National Quality Forum, the Rhode Island Affiliate of American College of Nurse-Midwives, the Rhode Island InterProfessional Education Collaborative, and the Rhode Island Department of Health Board of Midwifery.

ACHIEVEMENTS • Elisabeth Howard, PhD, CNM, FACNM, presented nationally for both the Association of Women’s Health and Neonatal Nurses and the American College of Nurse-Midwives on obstetric triage.

EXPERTISE This year, the Midwifery Division celebrates its 25th year at Women & Infants Hospital as an academic practice focused on clinical excellence and medical education. This program is one of the first to concentrate on the inter-professional education of medical students and obstetrics/gynecology residents and continues to be a model for midwifery practices across the United States. A collaborative team-based approach is used to facilitate patient care and the learning needs of residents and medical students in a variety of clinical areas, such as the Emergency Obstetrics & Gynecology Unit, Labor and Delivery, and the Mother/Baby Units. In addition to clinical education, the Midwifery Department provides ongoing curriculum development and support in the form of mentoring, didactic lectures, workshops, and simulation experiences. The Midwifery Division is well represented in key leadership positions on both a state and national level, including the American College of Nurse-Midwives Medical Education 16

• Linda Hunter, EdD, CNM, FACNM, was a special guest editor of the Journal of Perinatal and Neonatal Nursing special topics issue on perinatal infections. • Articles by both Linda Steinhardt, CNM, FNP-C, MS, and Edie Mcconaughey, CNM, MSN, were selected by and published in the Journal of Midwifery and Women’s Health special issue on Innovations in Teaching. • Janet Singer, MSN, CNM, along with four Brown residents in the Department of Obstetrics & Gynecology, published a Current Commentary in the journal Obstetrics & Gynecology entitled “Four Residents’ Narratives on Abortion Training: A Residency Climate of Reflection, Support, and Mutual Respect.” Excerpts from the article were featured on WBUR’s Commonhealth blog. Janet and her coauthors were interviewed on WBUR’s Radio Boston and All Things Considered, as well as NPR’s Here and Now.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I did all of my midwifery training here in the 1990s and I was so impressed with the midwifery faculty at the time that this became a priority professional goal to someday return and join their academic practice. As a nurse midwife, it’s a privilege to be such an integral part of resident and medical student education, and I am proud to be a member of the academic faculty. Our ob/gyn residents are awesome, and I chose Women & Infants to be a part of this supportive and collaborative team.” — Linda Hunter, CNM, EdD, FACNM, Midwifery Program

INTERIM PROGRAM DIRECTOR: Elisabeth Howard, PhD, CNM, FACNM Front row: Janet Singer, MSN, CNM; Linda Steinhardt, MS, FNP-C, CNM; Edie McConaughey, MSN, CNM Back row: Linda Hunter, EdD, CNM, FACNM; Joanne Miga; Elisabeth Howard, PhD, CNM, FACNM

THE DIANE ANGELINI LECTURE ON INTER-PROFESSIONAL EDUCATION AND COLLABORATION In 1990, Diane Angelini was hired as the director of midwifery in the Department of Obstetrics and Gynecology by Dr. Donald Coustan, the chair of the department. Together, with their leadership and vision, a collaborative, team approach to both teaching and patient services developed into the seamless inter-professional model it is today. Professor Diane Angelini retired in the fall of 2014 after 24 years of service to the Department of Obstetrics & Gynecology and the Women & Infants community. Diane’s scholarly contributions to the field of obstetric triage and to inter-professional education are impressive. She continues to be the senior and founding editor of the Journal of Perinatal and Neonatal Nursing. Since her establishment of the Midwifery Department, more than 2,500 medical students and 200 residents have been taught by the midwifery faculty. To honor Diane’s accomplishments, leadership and dedication to medical education, the Diane Angelini Lecture on Inter-Professional Education and Collaboration was established. To date, more than 70 group and individual contributions have been received from faculty, staff, and colleagues from across the country, graduates of the residency program, friends and family members. The inaugural lecture took place in July with invited speaker Dr. Rita Charon, a professor of clinical medicine and director of the Program in Narrative Medicine at the Columbia University College of Physicians and Surgeons. Dr. Charon, the founder of the Discipline of Narrative Medicine, spoke about a culture of collaboration through respect and appreciation of multiple perspectives on a situation. This imagination and vision to see past silos and divides became a culture of team-based care, which was radically ahead of its time. The lecture will continue to take place annually as a Department of Obstetrics & Gynecology Grand Rounds. These new lectures will honor and extend Diane’s influence to the next generation of midwives and obstetricians. 2015 Annual Report

Reproductive Endocrinology and Infertility complexity laboratory director (HCLD), will now be overseeing the laboratory. Dr. Ruben Alvero, formerly the division director and vice chair at the University of Colorado, was named the division and fellowship director, bringing additional experience in assisted reproduction, robotic surgery, and ovulatory disorders. Anchored by seasoned veterans and with the addition of new practitioners, the division is poised to take REI to the next level for families in Rhode Island and its surrounding communities.

ACHIEVEMENTS • Gary Frishman, MD, was elected secretary of the American Association of Gynecologic Laparoscopists, the first step in the presidential chain for the organization.

EXPERTISE • Achieving pregnancies in patients who otherwise would have great difficulty in conceiving. • Eliminating the passing on of heritable genetic diseases by testing embryos created by couples who are carriers of the gene for the disorder. • Normalizing the uterine cavity in women with recurrent miscarriages so that they can carry a pregnancy to term. • Preserving fertility in young women who are about to undergo potentially gonadotoxic chemotherapy. The Division of Reproductive Endocrinology and Infertility provides these and many other services to women from adolescence to menopause. Success in this fast-paced subspecialty requires human, technical and basic science resources, a team approach, and seamless integration of many moving parts. Drs. Gary Frishman, John Buster and Carol Wheeler have been at Women & Infants Hospital for many years and have been recognized by the medical and patient community for their expertise and dedication. Dr. Victoria Snegovskikh joined the group this year after graduating from her fellowship at Women & Infants. Dr. Shunping Wang, a long-time high 18

• Carol Wheeler, MD, served as co-chair of the Residency Education Committee for the National Association for Pediatric and Adolescent Gynecology (NASPAG). Dr. Wheeler was also elected chairman of the Pediatric and Adolescent Gynecology Special Interest Group for the American Society for Reproductive Medicine. • Ruben Alvero, MD, was elected to the Society for Reproductive Endocrinology and Infertility Board of Directors. Dr. Alvero was also co-author on two New England Journal of Medicine publications as part of the Reproductive Medicine Network. • Victoria Snegovskikh, MD, is currently completing a PhD program and was named chair of the Committee on Perinatal Research at the Siberian Perinatal Center. • John Buster, MD, was honored with a named lectureship by the American Society for Reproductive Medicine. He also gave the Dr. Sterling Williams lecture at the American College of Obstetrics and Gynecology Annual Meeting and was named a Castle Connolly Top Doctor. • Lynae Brayboy, MD is a Reproductive Scientist Development Program (RSDP) Scholar of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. She developed Girl Talk, a smart phone app offering sexual education for adolescent girls, evaluated its impact and presented her findings at NASPAG.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I chose to come to Women & Infants many years ago because of the amazing educational environment and opportunity to grow as a young faculty member. The faculty was very warm and welcoming to me and has continued to be so over the years.” — Carol Wheeler, MD Division of Reproductive Endocrinology and Infertility

DIVISION DIRECTOR: Ruben Alvero, MD Shunping Wang, PhD; Carol Wheeler, MD; John Buster, MD; Victoria Snegovskikh, MD; Ruben Alvero, MD; Gary Frishman, MD

PREIMPLANTATION GENETIC SCREENING While in vitro fertilization (IVF) has only been available to infertile couples for 40 years, today it accounts for 1.6% of all the babies born in the United States and well over 2% of those born in Europe. There have been three major innovations since the first successful IVF pregnancy delivered in 1978: the use of super-ovulation to improve gamete and embryo selection, the use of intracytoplasmic sperm injection (ICSI) to overcome severe male factor infertility, and the use of extended culture to allow for the development of blastocysts, a process that has yielded a significantly higher implantation rate than that previously available with cleaving embryo transfer. Assisted reproduction is on the cusp of the next revolution in technique: the use of genetic analysis to assess single gene defects and to screen for structural chromosomal abnormalities. Studies suggest that genetically normal embryos have a very high implantation rate and that in women up to age 42, finding a genetically normal embryo is the great equalizer in terms of success rates and that, even in older women, pregnancy rates are exceptionally good if a normal euploid embryo is identified. Women & Infants Center for Reproduction and Infertility has embraced this technology and is offering preimplantation genetic diagnosis (PGD) for single gene defects such as cystic fibrosis, Tay Sachs disease, and many other genetic abnormalities. Availability of this technique will substantially decrease disease burden for future generations. Preimplantation genetic screening (PGS) is offered for women who wish to assess whether their embryos are chromosomally normal. This will help to substantially reduce the impact of aging oocytes in reproductively older women, reduce miscarriage risk, and improve implantation rates. This game-changing technology gives the women and families of southern New England the most sophisticated approach to improving pregnancy outcomes available anywhere in the world. 2015 Annual Report

Clinical Research in Women’s Health

ACHIEVEMENTS • The department was successful in submitting and receiving a competitive third grant cycle for the The National Institute of Child Health & Human Development (NICHD) funded Women’s Reproductive Health Research (WRHR) program. • This year saw the establishment of the Hassenfeld Child Health Innovation Institute with a focus on discovering and applying strategies to improve the lives of children and their families in Rhode Island, nationally and globally. This is a collaboration with Brown University, Hasbro Children’s Hospital and Women & Infants Hospital and was launched with a $12.5 million gift from the family of Alan Hassenfeld.

EXPERTISE The goal of the Division of Research is to promote and support the research and scholarly activities of the Department of Obstetrics & Gynecology and the Women & Infants Hospital community. Through its multidisciplinary team, the Division of Research provides expertise in epidemiology, statistics, database development, grant submissions, grants management, public health, and research support. By fostering an environment that encourages innovation in women’s health, the division works towards the goal of generating the scientific evidence needed to advance health care for women and transforming this evidence into practical information that can be shared with health care providers and the community. The Division of Research is driven by collaboration, education, training and investigator support. The staff works to support faculty within the Department of Obstetrics & Gynecology with their research needs, including grant submission, data management and statistical work.

• Kristen Matteson, MD, MPH, presented at the Annual Clinical Meeting of the American College of Obstetricians and Gynecologists (ACOG), “Teaming Up for Women’s Health.” Her presentation was entitled, “Abnormal Uterine Bleeding: Wading Through the Evidence on Treatment Effectiveness.” • Dr. Matteson also presented at the International Federation of Gynecology and Obstetrics (FIGO) 2015 World Congress. • Dr. Matteson and Maureen G. Phipps, MD, MPH, presented “Scholarship of Discovery: Developing a Research Career for the Generalist” at the Annual Meeting of the Society for Academic Specialists in General Obstetrics and Gynecology (SASGOG). • Valery Danilack, PhD, MPH, and Dr. Phipps, post doctoral fellow, published new research about unexpected complications of low risk pregnancies in The American Journal of Obstetrics and Gynecology. • The grants and data teams provided assistance and statistical support for more than 91 research projects.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I choose to advance my career at Women & Infants and Brown because it provides me with world class practitioners and facilities that compel success while allowing me the freedom to pursue research that I am passionate about.” — Christine Brousseau, MD Division of Research

INTERIM DIVISION DIRECTOR: Kristen Matteson, MD, MPH Phinnara Has, MS; Christina Raker, ScD; Kristen Matteson, MD; Valery Danilack, PhD; E. Christine Brousseau, MD

WOMEN’S REPRODUCTIVE HEALTH RESEARCH (WRHR) CAREER DEVELOPMENT PROGRAM

In 2015, the National Institute of Child Health and Human Development (NICHD) awarded Women & Infants Hospital and Brown University an additional five years of grant funding to support the Women’s Reproductive Health Research (WRHR) Career Development program. With just 14 active sites throughout the country, this highly competitive program provides a tailored research and career development plan to enable junior faculty obstetrician/gynecologists to develop into leaders in women’s health research.

WRHR Scholars 2014–2015 included: Katina Robison, MD, a gynecologic oncologist with the hospital’s Program in Women’s Oncology, completed the WRHR Program in September 2015 after successfully transitioning to become the principal investigator on a multi-institution project funded by the Patient Centered Outcomes Research Institute (PCORI) to compare quality of life among women with endometrial cancer and stress urinary incontinence who undergo simultaneous surgeries.

The program is led by Maureen Phipps, MD, MPH (principal investigator) and Kristen Matteson, MD, MPH (research director) and is managed by the Division of Research. In granting Women & Infants/ Brown this funding, the NICHD has recognized the success of the WRHR program over the past 10 years and supports the vision and plan to train future leaders in women’s health research.

E. Christine Brousseau, MD, an academic specialist general obstetrics and gynecology in the Division of Emergency Obstetrics and Gynecology, is in her second year as a WRHR scholar. Dr. Brousseau is actively pursuing coursework to complete a master’s degree in public health at Brown University and is performing research on risk factors for complications during the postpartum period.

Dr. Matteson, along with Drs. Vivian Sung and Brenna Hughes, are all previous Women & Infants WRHR scholars who have remained on faculty after transitioning to independent funding and are committed to serving as research and career mentors for trainees and junior faculty.

The WRHR Program looks forward to recruiting a new scholar in 2016. By investing in the development of clinician-researchers in obstetrics and gynecology, Women & Infants is leading the way in developing and retaining women’s health physician-scientists as nationally recognized academic leaders. 2015 Annual Report

Urogynecology and Reconstructive Pelvic Surgery

ACHIEVEMENTS • Cassandra Carberry, MD, was lead author in the development of the guidelines on evaluation of pelvic organ prolapse for the American Urogynecologic Society Clinical Practice Committee. • B. Star Hampton, MD, published in The American Journal of Obstetrics and Gynecology for the APGO Undergraduate Medical Education Committee the article, “To the Point: Teaching the Obstetrics and Gynecology Medical Student in the Operating Room.” • Nicole Korbly, MD, previous resident in obstetrics and gynecology and fellow in FPMRS at Brown/ Women & Infants, joined the faculty in August 2015.

EXPERTISE The Division of Urogynecology and Reconstructive Pelvic Surgery at Women & Infants, also known as the Center for Women’s Pelvic Medicine and Reconstructive Surgery, is a tertiary care center for women with pelvic floor disorders. All physician faculty members are subspecialty fellowship board certified in Female Pelvic Medicine and Reconstructive Surgery (FPMRS). The Division’s staff has a depth of expertise in the diagnosis and treatment of pelvic floor disorders, sensory disorders of the genitourinary tract, voiding and bowel dysfunction, and reproductive tract anomalies. The Division is home to one of eight national clinical sites for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Pelvic Floor Disorders Network (PFDN) and conducts multi-centered trials studying pelvic floor disorders.

• Deborah Myers, MD, was selected to serve on the advisory committee of the FDA Obstetrics and Gynecology Medical Devices Panel. • Charles Rardin, MD, was the scientific program chair for the Society of Gynecologic Surgeons 41st annual scientific meeting. • Vivian Sung, MD, is the president-elect of the Society of Gynecologic Surgeons. • Kyle Wohlrab, MD, was selected to lead network development for the American Association of Gynecologic Laparoscopists. • Dr. Hampton chairs the Membership Committee for the American Urogynecologic Society, the Abstract Review Committee, and the Pelvic Anatomy Group for the Society of Gynecologic Surgeons.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I had trained here years ago and realized then that Women & Infants Hospital is a special place to work. Having worked in other hospitals in New England, I can say that none compare to the quality of patient care and collaboration amongst providers that exists here at Women & Infants.” — Deborah Myers, MD Division of Urogynecology and Reconstructive Pelvic Surgery

DIVISION DIRECTOR: Deborah Myers, MD

Front row: Nicole Korbly, MD; Deborah Myers, MD; Vivian Sung, MD Back row: Kyle Wohlrab, MD; Charles Rardin, MD; Cassandra Carberry, MD; B. Star Hampton, MD.

EXPANSION AND GROWTH TO SERVE OUR PATIENTS

This year the division moved its primary office location to a larger facility that has allowed for expansion and growth. The new space, approximately 12,500 square feet, brought with it additional exam rooms and consultation rooms, increased space for research, administrative and clinical staff, and a more patient-centered experience. There is improved privacy and patient flow, as well as increased access for those with disabilities.

sacral nerve function for incontinence issues is now possible with non-invasive sacral nerve testing. The division has diagnostic testing for those women who suffer from fecal incontinence with anal ultrasound and anal physiology testing. Office-based treatments for overactive bladder and urgency urinary incontinence using intra-detrusor on abotulinum toxin A and percutaneous tibial nerve stimulation are performed in a new procedure room.

This year also saw the addition of two new providers – Dr. Nicole Korbly joined faculty in August 2015 and Yanghee Courbron, NP in October 2015, to offer more services to women with pelvic floor disorders. The division is now better able provide outreach services throughout Rhode Island.

With clinical, academic and administrative offices in close proximity, the division is better able to support its clinical and academic missions with efficiency and increased collaboration amongst providers. Enhanced focus on patient-centered care is possible for women with pelvic floor disorders by hosting other specialties such as Care New England urology, colorectal surgery and gastrointestinal practices within one office setting, further underscoring the multidisciplinary efforts of the Rhode Island Center for Pelvic Floor Disorders.

Additional diagnostic tools and treatment options to the practice include perineal and vaginal ultrasound for location of mesh materials and to assist in diagnosis of prolapse. Assessment of

2015 Annual Report

Minimally-Invasive and Surgical Services

EXPERTISE 2015 saw the continued implementation of the structures that bring Women & Infants’ Minimally-Invasive and Surgical Services’ motto to life – “the right surgery, by the right surgeon, for the best outcomes.” Women & Infants’ program is focused around well-trained surgeons, advanced equipment, skilled nursing in the operating room, and a data-driven approach to assuring quality. The credentialing processes, combining ongoing surgical volume with simulation skills enhancement, assure that each surgeon is bringing the highest level of skills to each and every procedure and to each and every patient.

Across the surgical spectrum, every patient is an individual, and each case requires individualized plans. Through supporting of all forms of open and minimally-invasive surgery – vaginal, laparoscopic, and robotic – Women & Infants surgeons continue to reduce the number of large abdominal incisions for patients. This commitment results in reduced bleeding, infections, postoperative pain, and recovery periods.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I chose Women & Infants because of its large group of dedicated and talented surgeons and nurses, working together to provide the highest level of surgical care. We actively engage in quality measures, so we can be confident in providing the full array of minimally invasive surgery. Our patients deserve nothing less – the right procedure, by the right surgeon, for the best outcomes.” — Charles Rardin, MD Minimally-Invasive and Robotic Surgical Services •

MEDICAL DIRECTOR, SURGICAL SERVICES: Gary Wharton, MD

Beata Dizoglio, MD, Co-Director, Robotic Surgery Program Charles Rardin, MD, Director, Minimally-Invasive and Robotic Surgical Services

ACHIEVEMENTS

More than 7,500 operative cases were successfully completed this year, including the 2,000th robotic surgical procedure at Women & Infants Hospital in October by Beata DiZoglio, MD.

• Women & Infants continues to be recognized as a Center of Excellence in Minimally Invasive Surgery by the American Association of Gynecologic Laparoscopists. •

Efforts to sustain the vaginal surgery approach have resulted in an increase in the number of women undergoing vaginal hysterectomy – the original minimally invasive surgery. This provides better training for young doctors and keeps costs under control for the organization, while offering eligible women a procedure without any abdominal incisions at all. Of the 1,247 hysterectomies, 269 were abdominal, 275 were robotic, 244 were vaginal, and 459 were laparoscopic.

•

Charles Rardin, MD, director of Minimally-Invasive and Robotic Surgical Services, presented “MIS and Robotics Programs: Setting Up for Success” at the annual meeting of the American Congress of Obstetricians and Gynecologists (ACOG), with a meeting theme of “Teaming Up for Women’s Health.”

•

Surgical Services initiated the availability of the “cell saver” for all cases, lowering the use of blood and enhancing capabilities to care for those women who, for religious or other reasons, choose not to receive blood products.

• The massive transfusion protocols were updated this year to adhere to the latest data and recommendations for those who may need such products.

2015 Annual Report

Simulation Program

EXPERTISE The Women & Infants Simulation Center is the flagship of the Care New England Simulation Program. The center and its staff are dedicated to providing all employees with the training and tools they need to deliver state-ofthe-art health care. The Women & Infants Hospital on-site location promotes efficient and dedicated learning in a protected environment. New residents and fellows from the departments of Obstetrics & Gynecology and Pediatrics participate in orientation “Boot Camps” at the beginning of their learning careers at Women & Infants Hospital. In addition, regularly held “Simulation Days” prepare trainees and experienced clinicians for rare and complex surgical and medical events as well as procedures. The Simulation Center is also an integral training site for students from The Warren Alpert Medical School of Brown University and from the nursing schools at the Community College of Rhode Island, Rhode Island College and the University of Rhode Island. Interprofessional learning opportunities are open to trainees and practicing staff to enhance team roles and build communication skills. Simulation Days are held three times per year. The programs are organized and prepared by two elected obstetrics/ gynecology residents who have demonstrated an interest in simulation and educational curriculum development. The residents take the initiative in planning simulations that mimic rare and life-threatening procedures or novel techniques not yet mastered. Many of these simulations are taught by expert faculty who incorporate medical decision-making and team training into the learning objectives.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I came to Women & Infants from Chicago to train at the best ob/gyn

PROGRAM CO-DIRECTOR: Kyle Wohlrab, MD

program in the country. There was…and still is…no other program that can train young physicians to become the

ACHIEVEMENTS

best women’s health MD

The following is a small representation of some of the most recent simulation modules implemented in 2015:

in whatever path they

• Breech extraction and delivery using a high fidelity birthing mannequin with the incorporation of forceps training.

choose. Whether private practice, academic track, or subspecialty trained, our residents become leaders in our field. I

• Internal podalic version. • Robotic surgery training focusing on docking, trouble shooting and simulator training. • Code Blue and first responder simulations taught by Rhode Island Hospital ED chief residents. • Postpartum IUD insertion, indications and contraindications with visual teaching aides.

chose Women & Infants

• Vaginal morcellation techniques for large uteri during vaginal hysterectomy; subsequently presented at the AAGL Scientific Meeting.

because I knew no matter

• Intra and extraperitoneal laser safety focusing on safety, indications and troubleshooting.

what I decided to do, the door would always be open.” — Kyle Wohlrab, MD Division of Urogynecology and Reconstructive Pelvic Surgery

• Obstetrical hemorrhage stations have included methods to accurately estimate blood loss and a simulator for using the Bakri balloon. • Other simulation modules include advanced laparoscopic suturing, retropubic and transobturator slings, introduction to pelvic floor physical therapy, flexible hysteroscopy, palliative care and difficult conversations, maternal cardiac arrest, cardiac arrhythmias, repair of severe obstetrical lacerations, pulmonary embolism in the pregnant patient, psychiatric emergencies in ob/gyn, and pediatric gynecology. 2015 Annual Report

Inpatient Obstetrics

EXPERTISE Fiscal year 2015 saw 8,805 births at Women & Infants, an increase of nearly 400 births from fiscal year 2014. Inpatient Obstetrics continued to focus on improved clinical performance and patient satisfaction. The implementation of the obstetric dashboard is testimony to the clinical skill and dedication of Women & Infants’ medical and nursing staffs with eight of nine active clinical measures surpassing target. In addition, Inpatient Obstetrics has convened a multidisciplinary task force to develop and implement a Care New England-wide approach to preventing and treating obstetrical hemorrhage. Collaborative work with Blue Cross Blue Shield of Rhode Island continues with the completion of phase one of the region’s first maternity care partnerships, also known as the maternal bundle, which will offer incentives for strong clinical performance during intrapartum and postpartum care. Phase two work was initiated, focusing on standardizing and streamlining prenatal care for both normal and at-risk pregnancies.

MEDICAL DIRECTOR: James O’Brien, MD

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Measures Total Cesarean Delivery Rate

Primary Cesarean Delivery Rate

Numerator Denominator N:Number of cesarean deliveries performed D:Number of deliveries performed N:Number of cesarean deliveries performed without prior cesarean delivery D:Number of deliveries performed

VBAC Rate

N:Number of vaginal births to women with a prior cesarean delivery D:Number of births to women with a prior cesarean delivery

N:Pts w elective deliveries at 37–39 wks

Elective Deliveries < 39’0 weeks gestation

D:Pts deliver w/ 37–39 wks completed OR number of delivered

ObstetricalAdverse Outcomes Index (AOI)

Weighted measure of selected maternal and neonatal outcomes

Bench mark Base line

Target

Threshold

Oct-Dec 2014

Jan-Mar 2015

Apr-Jun 2015

CWISH (35.3%)

31.5%

30.8%

33.4%

30.9%

30.4%

30.2%

CWISH (19.5%)

18.1%

17.9%

18.8%

17.5%

16.8%

16.6%

CWISH (12.0%)

17.4%

17.7%

17.0%

20.6%

20.4%

19.6%

NPIC (6.1%)

0.0%

3.0%

3.3%

0.0%

0..0%

0.0%

CWISH (0.055)

0.05

0.06

0.053

0.044

Pending

Note: Data source National Perinatal Information Center (NPIC) and Cerner electronic medical record.

ACHIEVEMENTS • The obstetric dashboard was developed and implemented with the work of a multidisciplinary team. Fourteen clinical measures and one patient satisfaction measure are included, and the results from the first two quarters of fiscal year 2015 showed all measures meeting or exceeding targets. • Using a multidisciplinary approach to address the issue of obstetrical hemorrhage, the team is developing a new tool for risk assessment, assessing methods for quantifying blood loss, and recognizing and responding to a series of volume related triggers with the goal of improved quality outcomes.

• Women & Infants was designated a Baby-Friendly® USA Hospital, the second largest hospital in the nation to achieve this designation. This designation was the culmination of work by a multidisciplinary team that committed to changing the culture at Women & Infants by enhancing the maternity care practices that best support breastfeeding. Because of the high volume of births at Women & Infants Hospital, Rhode Island now ranks number one in the nation of babies born at a designated Baby-Friendly® USA Hospital.

• Women & Infants was designated as a Leapfrog Best Hospital – the only perinatal hospital in the country to achieve this recognition.

Community-Based Faculty ACHIEVEMENTS • Delivering care to a community of patients with diverse health care needs, the expertise in obstetrics and gynecology of the community-based faculty partners seamlessly with the subspecialty trained faculty, resulting in the delivery of high quality, state-of-the-art, cost effective clinical care to women of all ages. In 2015, there were more than 8,500 deliveries at Women & Infants Hospital and 7,300 surgeries performed. The overwhelming majority of these procedures were performed by faculty in the department.

EXPERTISE In 2015, the Department of Obstetrics & Gynecology at Women & Infants Hospital and The Warren Alpert Medical School of Brown University included 88 active communitybased faculty, 85 percent of whom hold Brown faculty appointments and seven with Emeritus status. Outstanding clinicians and educators, the community-based faculty – including obstetricians and gynecologists, midwives and other allied health professionals – are integral to the training of medical students and residents at the Alpert Medical School, to the care of patients at Women & Infants Hospital, and to research that aims to improve the health of women and newborns for generations to come.

• Committed to research, innovation and high quality, evidence-based medicine, the success of the department’s research program is based on the commitment of the community-based faculty to enroll their patients in clinical research protocols that will impact women’s health for generations to come. The community based faculty collaborated on research projects across Women & Infants Hospital, encouraging participation to ensure the success and validity of the research. Among many protocols, patients participated in the Maternal-Fetal Medicine Units Research Network, Project REACH (to help reduce the risk of postpartum depression in teens), and SHIPP (researching non-surgical treatments for heavy bleeding). • Highlighted by the countless teaching awards, the community-based faculty members play a vital role in teaching medical students and residents, sharing their expertise in obstetrics and gynecology and giving trainees clinical exposures to the practice of women’s health care. Fifty-seven community-based faculty served as medical student preceptors, five physicians participated in the medical student doctoring course, and more than 30 community-based faculty served as resident mentors. • The department is fairly unique in the ability to tap into the literally hundreds of years of experience of its community-based faculty. These physicians are divided up into teams, each with a team chief and associate team chief, to provide in-house, direct supervision to our residents-in training, helping them to provide outstanding care to the clinic population 24 hours a day, seven days a week.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Why

Women & Infants/ Brown?

“I chose Women & Infants for the perfect combination of academic medicine in a community setting. I love the sense of community among the physicians. People are always willing to help each out!” — Elizabeth Burchand, MD Center for Ob/Gyn

Front row: Audoen Maddock, MD; Dilek Cermik, MD; Kathleen Cote Bowling, MD; Lisa Domagalski, MD; Caroline Skudlarek, DO; Lisa Boyle, MD; Beata DiZoglio, MD Back row: Elizabeth Sullivan, MD; David Carcieri, MD; Marc Jaffe, MD; Laina Crowthers, MD; Gary Wharton, MD; Tawfik Hawwa, MD

FACULTY LISTING M. David Beitle, MD Clinical Assistant Professor

Debra Brendel, MD Clinical Assistant Professor

Rosa Bermudez-Emmanuelli, MD

Constance Brennan, MD

John J. Bert, MD Clinical Assistant Professor

Cheryl Brodsky, MD Clinical Assistant Professor

David A. Carcieri, MD Designated Institutional Official Clinical Assistant Professor

Kathleen Cote Bowling, MD Assistant Chief of Obstetrics & Gynecology Team Chief Clinical Associate Professor

Fred A. Brosco, MD Clinical Assistant Professor

Colleen Cavanaugh, MD Clinical Assistant Professor

Elizabeth Burchard, MD Clinical Assistant Professor

Dilek Cermik, MD Associate Team Chief Clinical Assistant Professor

Lisa Boyle, MD Clinical Assistant Professor

Terrence F. Cahill, MD Team Chief Clinical Associate Professor

Continued 2015 Annual Report

Community-Based Faculty

Wayne Clairborne, MD Clinical Associate Professor

Lindsay Clark Donat, MD

Annmarie Jurczak, MD Clinical Assistant Professor

Jose Eugenio-Colon, MD (2011â&#x20AC;&#x201C;2015) Mauro Colavita, MD Clinical Assistant Professor Jeannine Connelly, MD Clinical Assistant Professor Michael Coppa, MD Clinical Instructor Laina Crowthers, MD Associate Team Chief Clinical Assistant Professor

Stephen Falkenberry, MD Clinical Associate Professor Harris M. Galkin, MD Clinical Assistant Professor Michele Gange, MD President, Medical Staff Team Chief Clinical Assistant Professor Alfredo Gil, MD

Suzanne Dambek, MD Clinical Instructor Anh-Tai Dang, MD Clinical Assistant Professor Mary Catherine DeRosa, MD Clinical Assistant Professor Paula DeYoung, MD Clinical Instructor John DiOrio, Jr., MD Clinical Assistant Professor Beata DiZoglio, MD Co-Director, Robotics Surgery Program Clinical Assistant Professor

Amr Kader, MD Clinical Instructor Nabil Khoury, MD Clinical Associate Professor Emeritus Erika Klein, MD Clinical Assistant Professor Tolga Kokturk, MD Clinical Assistant Professor Altug Koymen, MD Clinical Assistant Professor

Debra Goldman, MD Associate Team Chief Clinical Assistant Professor

Donna LaFontaine, MD Clinical Associate Professor

Michael Gottlieb, MD

Christine LaRose, MD

Robin Gray, DO Clinical Assistant Professor

Stacey P. Lievense, MD Clinical Assistant Professor

Cynthia M. Hanna, MD Clinical Assistant Professor

Althea Lindsay, DO Audoen D. Maddock, MD

Tawfik F. Hawwa, MD Team Chief Clinical Associate Professor

Henry G. Magendantz, MD Clinical Associate Professor Emeritus

Jennifer Hosmer, MD Clinical Assistant Professor

Nayana Manjunath, MD Clinical Instructor

Marc A. Jaffe, MD Clinical Assistant Professor

Carol Manning, MD

Joseph DiZoglio, MD Lisa Domagalski, MD Associate Team Chief Clinical Assistant Professor 32

Beth Marcaccio, MD Clinical Assistant Professor

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Elizabeth Mayhall, MD Clinical Instructor

Adrienne J. Perry, MD Clinical Assistant Professor

Karen McGoldrick, MD Clinical Assistant Professor

Martha Pizzarello, MD Clinical Assistant Professor

Megan McMahon, MD Clinical Assistant Professor

Marylin Powers, DO Clinical Assistant Professor

Carroll Medeiros, MD Team Chief Clinical Assistant Professor

Donald Ramos, MD Clinical Assistant Professor

Jane Sharp, MD Associate Team Chief Clinical Assistant Professor Santina L. Siena, MD (1982â&#x20AC;&#x201C;2015) Clinical Assistant Professor Meera Simoes-Varma, MD Clinical Assistant Professor Caroline M. Skudlarek, DO Clinical Assistant Professor

Natujwa Mmbaga, MD (2013â&#x20AC;&#x201C;2015)

Rebecca W. Randall, MD Clinical Assistant Professor

Samir Moubayed, MD Clinical Associate Professor Emeritus

Pablo Rodriguez, MD Clinical Associate Professor

John Murphy, MD Clinical Assistant Professor Emeritus

Christian Roman-Rodriguez, MD

Marshall Taylor, MD Clinical Assistant Professor Emeritus

Caitlin Saint-Aubin, MD Clinical Assistant Professor

Marguerite Vigliani, MD Clinical Professor

Jessica Salak, MD Clinical Assistant Professor

Benjamin Vogel, MD Clinical Assistant Professor

Robert Salk, DO Clinical Assistant Professor

Gary G. Wharton, MD Medical Director, Surgical Services Clinical Assistant Professor

Anne Murray, MD Associate Team Chief Clinical Assistant Professor Laura S. Nevel, MD Clinical Assistant Professor J. Douglas Nisbet II, MD Chief, Kent Hospital Obstetrics & Gynecology Clinical Assistant Professor Nwamaka M. Onwugbenu, MD Frank Pensa, MD Clinical Associate Professor Michael Pepi, MD Chief, Memorial Hospital Obstetrics & Gynecology Clinical Assistant Professor

Mark F. Scott, MD Clinical Assistant Professor Bahram Shah-Hosseini, MD Clinical Assistant Professor Reza Shah-Hosseini, MD Clinical Associate Professor Emeritus

Elizabeth Sullivan, MD Associate Team Chief Clinical Instructor

Emily White, MD Clinical Assistant Professor Doreen Wiggins, MD Clinical Assistant Professor Robert Williams, MD Clinical Associate Professor Bethany Wortman, MD 2015 Annual Report

Hospital-Based Faculty

FACULTY LISTING Chair Maureen G. Phipps, MD, MPH Chace-Joukowsky Professor Professor, Obstetrics & Gynecology and Epidemiology Vice Chair Deborah L. Myers, MD Professor Assistant Chief Kathleen Cote Bowling, MD Clinical Associate Professor Ambulatory Care Renee Eger, MD Medical Director Assistant Professor (Clinical) Rebecca H. Allen, MD Associate Director Medical Student Core Clerkship Assistant Professor, Obstetrics & Gynecology and Medical Science Rebecca Crichton, MD Clinical Assistant Professor Beth Cronin, MD Assistant Professor (Clinical) Sarah Fox, MD (1998–2015) Assistant Professor (Clinical) Amy Gottlieb, MD (2005–2015) Associate Professor (Clinical) Nurse Practitioners Ann Cooper, RNP Senior Teaching Associate

Erin Dobson, RNP Senior Teaching Associate

Michael Sisitsky, MD Assistant Professor (Clinical)

Ann Holdredge, CNM, NP Senior Teaching Associate

Amy Snyder, MD Assistant Professor (Clinical)

Patricia O’Connell, RNP Senior Teaching Associate

Kate Zaluski, MD Assistant Professor (Clinical)

Darcy Renagan, MSN, WHNI-BC

Nurse Practitioners Tara Capuano, MSN, RNP Teaching Associate

Anne Stulik, RNP Senior Teaching Associate

Heather Aliotta, NP Emergency Obstetrics and Gynecology Roxanne Vrees, MD Medical Director Associate Director, Residency Program Assistant Professor E. Christine Brousseau, MD Assistant Professor Chelsy Caren, MD Assistant Professor (Clinical) Beth Cronin, MD Assistant Professor (Clinical) Mohamad Hamdi, MD Assistant Professor (Clinical) Donna LaFontaine, MD Clinical Associate Professor Alexandra Mainiero, MD (2014–2015) Rachel Shepherd, MD Assistant Professor (Clinical)

Melissa Pragana, NP Gynecologic Oncology and Breast Health C. O. (Skip) Granai III, MD Division Director Director, Fellowship Program Professor Paul DiSilvestro, MD Associate Division Director Chair, Women & Infants Hospital Institutional Review Board Professor Steven Cohen, MD David Edmonson, MD Assistant Professor (Clinical), Surgery and Obstetrics & Gynecology Jennifer Gass, MD Director, Surgery Co-Director, Breast Health Center Associate Professor, Surgery and Obstetrics & Gynecology

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Obstetrics & Gynecology

Kyu Kwang Kim, PhD Assistant Professor (Research) Robert D. Legare, MD Co-Director, Breast Health Center Director, Cancer Genetics and Prevention Program Associate Professor (Clinical), Obstetrics & Gynecology and Medicine Cara Mathews, MD Assistant Professor Richard Moore, MD (2002–2015) Director, Center for Biomarkers and Emerging Technologies Director, Molecular Therapeutics Laboratory Professor Sonali Pandya, MD Tina Rizack, MD, MPH Assistant Professor (Clinical), Medicine and Obstetrics & Gynecology Katina Robison, MD Assistant Professor Bachir Sakr, MD Director, Medical Oncology Assistant Professor (Clinical) William Sikov, MD Associate Director of Research Associate Professor (Clinical), Medicine and Obstetrics & Gynecology Rakesh Singh, PhD Assistant Professor (Research) Ashley Stuckey, MD Assistant Professor, Obstetrics & Gynecology and Medical Science

Sabrina Witherby, MD Naohiro Yano, MD, PhD Research Associate Nurse Practitioners Patricia K. Barlow, MSN, ANP-BC Megan T. Gaynor Charette, RNP, MSN Grace Cook, RN, FNP, MS, OCN Maeve Dargush, MSN, RNP Patricia Karwan, DNP, RNP Paige McCann, MSN, RNP Molly Merlino, MSN, RNP Elizabeth S. Ricci, RNP, MS Laura Saccoccio, FNP-BC, MSN Wendy Young, NP-C, MSN Maternal-Fetal Medicine Katharine Wenstrom, MD Division Director Professor

Barbara O’Brien, MD (2007–2015) Associate Professor Dwight Rouse, MD Professor, Obstetrics & Gynecology and Epidemiology Erika Werner, MD Assistant Professor Nurse Faculty Julie Daley, RN Teaching Associate Midwifery Elisabeth Howard, PhD, CNM, FACNM Interim Program Director Assistant Professor (Clinical) Linda Hunter, EdD, CNM, FACNM Assistant Professor (Clinical)

Tanya L. Booker, MD Assistant Professor (Clinical)

Edie McConaughey, MSN, CNM Senior Teaching Associate

Stephen Carr, MD Director, Prenatal Diagnosis Center Professor

Janet Singer, MSN, CNM Senior Teaching Associate

Donald R. Coustan, MD Professor Sarah Davis, MD Assistant Professor (Clinical) Matthew Esposito, MD Assistant Professor (Clinical) Brenna Hughes, MD Director, Fellowship Program Director, Women’s Infectious Disease Consult Service Associate Professor

Linda Steinhardt, MS, FNP, CNM Senior Teaching Associate Reproductive Endocrinology and Infertility Ruben Alvero, MD Division Director Director, Fellowship Program Professor Lynae Brayboy, MD Assistant Professor (Research) John Buster, MD Professor

Rebecca Vanasse, MD 2015 Annual Report

Hospital-Based Faculty

Gary Frishman, MD Director, Residency Program Professor Kelly Pagidas, MD (1999–2015) Associate Professor Victoria Snegovskikh, MD Assistant Professor (Clinical) Carol Wheeler, MD Associate Professor (Clinical) Clinical Research in Women’s Health Kristen A. Matteson, MD, MPH Interim Division Director Director, Resident Research Associate Professor E. Christine Brousseau, MD Assistant Professor Susan Cu-Uvin, MD Professor, Obstetrics & Gynecology and Medicine Valery Danilack, PhD Research Associate/Post-Doctoral Fellow Christina Raker, ScD Research Associate Dwight Rouse, MD Professor. Obstetrics & Gynecology and Epidemiology Urogynecology and Reconstructive Pelvic Surgery Deborah L. Myers, MD Division Director Professor

B. Star Hampton, MD Director, Medical Student Core Clerkship Associate Professor, Obstetrics & Gynecology and Medical Science Nicole B. Korbly, MD Assistant Professor (Clinical)

Brenda Roy, MD Adjunct Assistant Professor Timothy Shafman, MD Adjunct Assistant Professor Emeritus Appointments in Obstetrics & Gynecology Diane Angelini, EdD, CNM Professor (Clinical) (Emerita)

Charles R. Rardin, MD Director, Fellowship Program Director, Minimally-Invasive and Robotic Surgical Services Andrew Blazar, MD Associate Professor Clinical Professor (Emeritus) Vivian W. Sung, MD, MPH Associate Professor

Patrick Sweeney, MD, PhD Professor (Emeritus)

Kyle J. Wohlrab, MD Co-Director, Simulation Center Assistant Professor (Clinical) Nurse Practitioners Yanghee Courbron, RN, MS, WHNP-BC Leah K. Moynihan, RNC, MSN

Secondary Appointments in Obstetrics & Gynecology Eli Adashi, MD, MS Professor

Inpatient Obstetrics James J. O’Brien, MD Medical Director Associate Professor (Clinical) Surgical Services Gary Wharton, MD Medical Director Clinical Assistant Professor Adjunct Appointments in Obstetrics & Gynecology Sandra Carson, MD Adjunct Professor Darleen Gabeau, MD Adjunct Assistant Professor

Kenneth Chen, MD Assistant Professor Melissa Clark, PhD (2007–2015) Professor Jennifer Clarke, MD, MPH Associate Professor Francois Luks, MD Professor Raymond Powrie, MD Professor David Savitz, PhD Professor Caron Zlotnick, PhD Professor

Cassandra L. Carberry, MD Assistant Professor (Clinical) 36

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Obstetrics & Gynecology

CURRENT RESIDENTS PG-1 (2015–2019) Kelly Benabou, MD Kathleen Cohen, MD Michael Cohen, MD Jenny David, DO Luwam Ghidei, MD Sebastian Ramos, MD Bridget Spelke, MD Hope Yu, MD PG-2 (2014–2018) Libertad Flores, MD Mary Friedman, MD Meghana Limaye, MD Caitlin MacGregor, MD Reeva Makhijani, MD Katherine Miller, MD Desmond Sutton, MD Meena Theva, MD PG-3 (2013–2017) Ilina Datkhaeva, MD Jenna Emerson, MD Dennis Goulet, MD, MPH Alexandra Jen, MD Martha Kole, MD Kristin Rojas, MD Jennifer Villavicencio, MD Erica Weston, MD PG-4 (2012–2016) Karen Browning, MD Elizabeth Connor, MD Stephen Fiascone, MD Valerie Flores, MD Erin Greenberg, MD Alisse Hauspurg, MD Warren Huber, MD, PhD Jeffrey Sperling, MD, MS

RECENT RESIDENT GRADUATES (2011–2015) Amy Bregar, MD, MS Danielle Dray, MD Maureen Hamel, MD Tiffany Hunter, MD, MA Alicja Kreczko, MD Marguerite Palisoul, MD Leanna Sudhof, MD, MPH Kristin Taylor, MD

CURRENT FELLOWS Program in Women’s Oncology (Gynecologic Oncology and Breast Health) Evelyn Cantillo, MD (2014–2018) Rebecca Kwait, MD (Breast Health) (2015–2016) Elizabeth Lokich, MD (2012–2016) Matthew Oliver, MD (2015–2019) Anze Urh, MD (2013–2017)

RECENT FELLOWSHIP GRADUATES Emily Hill, MD (2011–2015) Fellow in Gynecologic Oncology and Breast Disease Lindsay Maggio, MD (2012–2015) Fellow in Maternal-Fetal Medicine Sarah Pesek, MD (2014–2015) Fellow in Breast Disease Sonali Raman, MD (2012–2015) Fellow in Urogynecology and Reconstructive Pelvic Surgery Victoria Snegovskikh, MD (2012–2015) Fellow in Reproductive Endocrinology and Infertility

Maternal–Fetal Medicine Catherine Albright, MD (2013–2016) Rosemary Froehlich, MD (2014–2017) Maureen Hamel, MD (2015–2018) Reproductive Endocrinology and Infertility Virginia Mensah, MD (2014–2017) Urogynecology and Reconstructive Pelvic Surgery Kristin Jacobs, MD (2015–2018) Annetta Madsen, MD (2014–2017) Kavita Mishra, MD (2013–2016) Jonathan Shaw, MD (2013–2016)

2015 Annual Report

Grant Funding â&#x20AC;&#x201D; 2015

Our grant funding agencies and foundations have included:

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Allen, RH: NICHD. Contraceptive Clinical Trials Network (HHSN2752013000151) 2013–2020. Role: Co-PI. Phipps, MG: Role: Co-PI.

Cu-Uvin, S: NIH/FIC. “AIDS International Research and Training Program (Fogarty Center).” (5D43TW000237 (Cu-Uvin)). 6/1/10–4/30/15. Role: PI.

Allen, RH: Society of Family Planning, “Helping women choose between local anesthesia alone and IV sedation for first-trimester surgical abortion.” 2014–2016. Role: PI.

Cu-Uvin, S: NIH. “Reproductive Hormones and Their Impact on HIV-1 Acquisition.” (R01HD072693 (Cu-Uvin/Ramratnam/Gupta)). 4/14/12–2/28/17. Role: Co-PI.

Brayboy, L: NIH/NICHD Reproductive Scientist Development Program, “The Role of Multidrug Resistant Transporters in the Protection of the Ovary from Chemotherapy.” (K12HD000849 (Moley)) Role: Physician Scientist.

Cu-Uvin, S: NIH/NIAID. “Lifespan/Tufts/Brown–Center for AIDS Research.” (P30A1042853 (Carpenter)). 9/1/98–6/30/17. Role: Associate Director; Director: HIV and Women and Underserved Populations Core.

Brayboy, L: WIH Perinatal Biology COBRE. “Vasa dysfunction leads to abnormal chromosomal segregation and increased rates of miscarriage.”

Cu-Uvin, S: NIH. “Monoclonal Antibody-based Multipurpose Microbicides.” (U19A1096398 (Anderson)) 7/1/11–6/2016. Role: Co-I.

Carr, S: NIH/NIDA. “Fetal Behavior, Brain & Stress Response: Ultrasound Markers of Maternal Smoking.” (R01 DA036999-01 (Stroud)). 2013–2018. Role: Co-I. Clark, MA: AHRQ. “Family evaluation of hospice care survey.” (Teno) 2/2010−present. Role: Investigator. Clark, MA: Annie E. Casey Foundation (Subcontract with University of Washington). “Evidence 2 Success.” (Catalano). 3/2013–present. Role: Investigator/Subcontract PI. Clark, MA: AHRQ. “Evaluating the impact of patient-centric home health quality reports.” (R21 HS021879 (Baier)). 9/2012–present. Role: Investigator/Subcontract PI. Clarke, JG: NICHD. “Contraceptive Awareness and Reproductive Education.” (1R01HD065942 (Stein)). 7/1/11–6/30/16.

DiSilvestro, P: Kettering Foundation. “Prospective Breast Cancer Tissue and Serum Bank.” 2010–present. Role: PI. DiSilvestro, P: Everett F. Boyden Trust. “Prospective Breast Cancer Tissue and Serum Bank.” 2010–present. Role: PI. DiSilvestro, P: NIH. “Gynecologic Oncology Group of the National Cancer Institute.” U10-CA27469 (DiSaia). 2004–2/28/15. Role: Site PI. DiSilvestro, P: NCI/CRSU. “Gynecologic Oncology Group of the National Cancer Institute, Leadership Grant, Protocol 219.” 2006–present. Role: PI. DiSilvestro, P: AstraZeneca /GOG 3004. “A Phase III randomized, double blind, placebo controlled, multicenter study of Olaparib maintenance monotherpay in patients with BRCA mutated advanced (FIGO Stage III_IV) ovarian cancer following first line platinum based chemotherapy.” 2013–present. Role: International Project PI.

2015 Annual Report

Grant Funding

DiSilvestro, P: Boehringer–Ingelheim 1199.15. “Multicenter, Randomized, Double-Blind, Phase III Trial to Investigate the Efficacy and Safety of BIB 1120 in Combination with Carboplatin and Paclitaxel compared to Placebo plus Carboplatin and Paclitaxel in Patients with Advanced Ovarian Cancer.” 2010–present. Role: PI. DiSilvestro, P: Genetech. “A randomized, open-label, multicenter, phase II trial evaluating the safety and activity of DNIB0600A compared to pegylated liposomal doxorubicin administered intravenously to patients with platinum-resistant ovarian cancer (GO28609).” 2013–present. Role: PI. DiSilvestro, P: Janssen Pharmaceuticals. “A randomized, openlabel study comparing the combination of YONDELIS and DOXIL/ CAELYS with DOXIL/CAELYX Monotherapy for the treatment of advanced-relapsed epithelial ovarian, primary peritoneal, or fallopian tube cancer.” 2013–present. Role: PI. DiSilvestro, P: Tesaro. “A randomized, open-label study of maintenance with Nariparib versus placebo in patients with platinum sensitive ovarian cancer.” 2013–present. Role: PI. Hughes (Anderson), BL: CDC and Prevention and National Center on Birth Defects and Developmental Disabilities. “Clinical Trial of Behavioral Modification to Prevent Congenital Cytomegalovirus.” (1U01DD000921 (Anderson)) 9/28/2012- 3/27/2015. Role: PI. Hughes (Anderson), BL: Brown University - 2014 Dean’s Emerging Areas of New Science (DEANS) Awards. “The impact of vaginal microbiome on HIV infectivity among pregnant and nonpregnant women.” 7/1/2014–6/30/2015. Role: Co-PI. Hughes (Anderson), BL: NIAID / DMID Contract. “Identification of Herpes Simplex Virus (HSV) Shedding in the Female Genital Tract of Pregnant and Nonpregnant Women by GeneXpert PCR, Routine PCR, and Culture.” (HIISN 272201100037C (Kimberlin/Whitely)). 3/2015–9/2016. Role: Site PI. 40

Madsen, A: American Urogynecologic Society Foundation. “Peer support for Pelvic Floor Disorders (PEERS).” 7/1/2015–6/30/2017. Role: PI Sung, V: Role: Primary Mentor Mathews, C: AstraZeneca. “A Phase III randomized, double blind, placebo controlled, multicenter study of Olaparib maintenance monotherpay in patients with BRCA mutated advanced (FIGO Stage III_IV) ovarian cancer following first line platinum based chemotherapy.” 2013–present. Role: Site PI. Mathews, C: Rhode Island Foundation. “Molecular biomarkers in uterine papillary serous cancer: biopsy vs. hysterectomy.” 3/1/2014–2/28/2015. Role: PI. Matteson, KA: NIH/NICHD. “Levonorgestrel intrauterine system versus oral contraceptives for heavy menses.” (R01 HD074751 (Matteson)) 2/2013–1/31/17. Role: PI. Clark, MA: Role: Investigator / PI Brown subcontract. Moore, R: NIH / NCI. “Urine and serum biomarkers for screening and diagnosis of ovarian cancer.” (R01 CA108990 (Lokshin)). 8/1/10–1/31/15. Role: PI (Subcontract). Moore, R: NIH / NCI. “Early detection of epithelial ovarian cancer.” University of Texas MD Anderson Cancer Center SPORE in ovarian cancer. (P50 CA 083639 (Bast)) 9/2/10–8/31/15. Role: Site PI. Moore, R: Swim Across America Research Development Grant. 2010 to present. Role: PI. Moore, R: Fujirebio Diagnostics, Inc. Unrestricted grant to support Center for Biomarkers and Emerging Technologies (CBET). 2010–present. Role: PI.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Moore, R: Brown University – 2014 Dean’s Emerging Areas of New Science (DEANS) Awards. “Establish genomic targets of HE4 & antisense therapy for treatment of ovarian cancer.” 7/1/2014–6/30/2015. Role: Co-PI. Pagidas, K: AbbVie. Clinical Study Protocol M12-671A. “Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Elagolix in Subjects with Moderate to Severe Endometriosis Associated Pain.” 9/2013-8/2015. Role: PI. Phipps, MG: NIH NICHD. “Brown University/Women & Infants Women’s Reproductive Health Research Program.” (2K12 HD050108 (Phipps)). 9/27/05–3/31/15. Role: PI. Matteson, KA: Role: Research Director. Robison, KM: Role: Scholar (3/31/09–7/31/11, 10/1/12–9/30/2015). Brousseau, EC: Role: Scholar (1/15/14–present). Phipps, MG: NIH NIMH. “Project REACH: Preventing Postpartum Depression in Adolescent Mothers.” (R01 MH093342 (Phipps)). 8/1/11–4/30/17. Role: PI. Zlotnick, C: Role: Co-I. Phipps, MG: NIH NIDA. “Maternal smoking: HPA and Epigenetic Pathways to Infant Neurobehavioral Deficits.” (R01DA031188 (Stroud)). 12/1/11–4/30/16. Role: Co-I. Phipps, MG: NHLBI. “Preventing excessive gestational weight gain in obese women.” (U01 HL114377 (Phelan)). 09/23/11–07/31/16. Role: Co-I. Phipps, MG: NIH NINR. “RCT of a tailored walking program to reduce stress among pregnant women.” (R01NR014540-01A1 (Battle / Salisbury)). 9/17/14–7/31/19. Role: Co-I.

2015 Annual Report

Grant Funding

Rardin, C: Foundation for Female Health Awareness. “vaULT: Vaginal Uphold Hysteropexy and Laparoscopic Sacral Hysteropexy for the Treatment of Uterovaginal Pelvic Organ Prolapse: A Parallel Cohort Study.” 2011–present. Role: PI. Rardin, C: Pelvalon, Inc. “LIBERATE: A Clinical Evaluation of the Eclipse™ System, a Vaginal Bowel Control (VBC) Therapy for Fecal Incontinence in Women.” 2015–present. Role: RI Site PI. Rardin, C: Solace Therapeutics. “SUCCESS Trial: Stress Urinary inContinence Control/Efficacy and Safety Study. Randomized Controlled trial of the VesAir balloon system.” 2015–present. Role: RI Site PI.

Robison, K: Everett Boyden Trust, “The effect of neoadjuvant depot medroxyprogesterone acetate on glandular cellularity in women with complex atypical hyperplasia or grade 1-2 endometrial adenocarcinoma awaiting hysterectomy.” 12/1/2014–12/1/2015. Role: PI. Robison, K: Patient Centered Outcomes Research Institute (PCORI) “Ovarian Cancer Patient-Centered Decision Aid.” 03/17/2015–06/16/2016. Role: Site PI. Robison, K: Patient Centered Outcomes Research Institute (PCORI) “Cancer of the Uterus and Treatment of Incontinence (CUTI).” PCORI: FC14-1409-22034 (Robison)) 06/01/2015–06/01/2018. Role: PI Wohlrab, K: Role: Co-PI. Sung, VW: Role: Co-I Rouse, DJ: NIH/NICHD. “Cooperative Multicenter Network of Maternal Fetal Medicine Units.” (PHS#510HD040500 (Rouse)). 4/2011-3/2016. Role: PI. Anderson, BL: Role: Alternate PI. Savitz, DA: NIH. “The epidemiology of postpartum depression and associated childhood outcomes.” (1 R21 HD073030 Mount Sinai School of Medicine (Silverman)) 08/01/13–07/31/15.

Robison, K: NIH/NCI. GOG Protocol 237, Comparative analysis of CA-IX, P16, proliferative markers, and human papilloma virus in the diagnosis of significant cervical lesions in patients with a cytologic diagnosis of atypical glandular cells (AGC). 02/09–present. Role: Site PI. Robison, K: Lura Cook Hull Trust Award. “The effect of neoadjuvant depot medroxyprogesterone acetate on glandular cellularity in women with complex atypical hyperplasia or grade 1-2 endometrial adenocarcinoma awaiting hysterectomy.” 12/1/14–12/1/15. Role: PI.

Savitz, DA: AHRQ. “National Research Service Award.” (2 T32 HS000011 (Mor)). 07/01/13–06/30/18 Role: Contributor. Savitz, DA: NIH NIEHS. “Air pollution and pregnancy-induced hypertension in Rhode Island.” (R21 ES1023073 (Wellenius)). 07/01/13–7/31/15. Role: Site–PI Phipps MG: Role: Co-I.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Savitz, DA: NIH NICHD. “Effect of iatrogenic delivery at 34–38 weeks’ gestation on pregnancy outcome.” (1 R01 HD077592 (Savitz)) 5/15/14–4/30/20. Role: PI. Hughes (Anderson), BL: Role: Co-I. Savitz, DA: NIH. “Marcellus shale development, respiratory and reproductive outcomes in Pennsylvania.” (1R21ES023675 (Schwartz B)). 12/1/13–11/30/15. Role: Co-I. Sung, VW: NIH / NICHD. “The Pelvic Floor Disorders Network”Brown/Women & Infants Site. (U10 HD 069013). 7/1/2011–6/30/2016. Role: Site PI. Myers DM: Role: Site Co-PI. Sung, VW: NIH / NICHD. “Patient-reported outcomes in functioning for female pelvic floor disorders.” K23HD060665 6/16/09–5/31/2014 (NCE 5/31/15). Role: PI. Sung, VW: NIH / NIDDK. “Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN).” (U01 DK097772 (Bradley/ Kreder)). 9/30/12–5/31/17. Role: Co-I. Sung, VW: SGS-ABOG. “Building evidence-based medicine skills in gynecology: A partnership between SGS and ABOG.” 4/20134/2015. Role: PI on behalf of Society of Gynecologic Surgeons. Sung, VW: AHRQ. “Patient Centered Outcomes Research (PCOR) Institutional Mentored Career Development Program.” (K12) (Lau). Role: Mentor, Recruitment Committee member. Sung, VW: NIH/NIA. “Investigation to Minimize Prolapse Recurrence of the Vagina using Estrogen (IMPROVE).” (1R01AG047290-01A1 (Rhan)). 8/15/2015–4/30/2020. Role: Co-I.

Werner, E: Brown University. “Rhode Island Child Obseogen Study–Pilot Phase.” (Braun) 5/2014–5/2015. Role: Co-PI. Werner, E: rEVO Pharmaceuticals.“Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1), Protocol no. RB AT PPE 01-13.” May 2014–May 2016. Role: PI. Werner, E: NICHD/MFMU Network. “Myo-inositol to prevent gestational diabetes mellitus.” Start date pending. Role: Co-PI. Zlotnick, C: NIH/NIMH. “Treatment of PTSD in Residents of Battered Women’s Shelters.” (MH095767-01(Johnson)). 07/1/12–06/30/16. Role: Co-I. Zlotnick, C: NICHD. “Computer Intervention for HIV/STI Risk and Drug Use during Pregnancy.” (R21 HD075658-01). 9/3/13–7/30/15. Role: Joint PI. Zlotnick, C: NICHD. “Computer-based Intervention for Battered Sheltered Women with Substance Use.” (R34 DA 038770). 04/15/15–02/28/18. Role: PI. Zlotnick, C: NICHD. “Dating Violence Prevention for Juvenile Justice Girls.” R01 HD080780-01 (Rizzo) 04/-1/15–03/31/20. Role: Co-I. Zlotnick, C: “Addressing the Health Concerns of VA Women with Sexual Trauma.” (W81XWH-14-1-0368). 09/2014–08/2017. Role: PI. Zlotnick, C: CDC. “Preventing Sexual Aggression among High School Boys.” (1-U01-CE002541-01 (Orchowski)). 09/30/2014–09/29/2018. Role: Co-I.

2015 Annual Report

Peer-Reviewed Publications

Adashi EY. Global women’s health in the balance. Preface. Semin Reprod Med. 2015 Jan;33(1):3-4. PMID: 25565504. Adashi EY, Kocher RP. Physician self-referral: Regulation by exceptions. JAMA. 2015 Feb 3;313(5):457-8. PMID: 25580941. Adashi EY, Gao H, Cohen IG. Hospital-Based Active Shooter Incidents: Sanctuary under Fire. JAMA. Mar 24-31;313(12):1209-1210. PMID: 25719264. Adashi EY. Money and Medicine: Indivisible and Irreconcilable. AMA J Ethics. 2015 Aug 1;17(8):780-6. PMID: 26270880. Adashi EY. Howard Wilbur Jones Jr., MD: A giant in our midst. Fertil Steril. 2015 Sep;104(3):531-2. [Epub 2015 Aug 4]. PMID: 26247567. Adashi EY. A Same-Sex Infertility Health Insurance Mandate in Maryland? JAMA. 2015 Jul7;314(1):15. PMID: 26151251. Adashi EY, Kocher RP. Government Regulations on Physician SelfReferral—Reply. JAMA. 2015 May 19;313(19):1977-8. PMID: 25888474. Adashi EY. Fifty years after Huxley: The Roadmap of Reproductive Medicine Revisited and Updated: The 2015 SRI-Pardi Distinguished Scientist Plenary Lecture of the Society of Reproductive Investigation. Reprod Sci. 2015 Nov; 22(11):1220-5. PMID: 26459419. Albright CM, Ali TN, Lopes V, Rouse DJ, Anderson BL. Lactic acid measurement to identify risk of morbidity from sepsis in pregnancy. Am J Perinatol. Apr 2015. 32(5): 481-6. doi: 10.1055/s-0034-1395477. PMID: 25486284. Albright CM, Emerson JB, Werner EF, Hughes BL. Thirdtrimester prenatal syphilis screening: A cost-effectiveness analysis. Obstet Gynecol. 2015 Sept;126(3):479-85. PMID: 26244531. Albright C, Wenstrom KD. Malignancies in pregnancy. Best Practice & Research Clinical Obstet Gynecol. 2015. In press.

Ali S, Lankes HA, Backes F, Moore K, Mutch D, Robison K, Behbakht K, Waggoner S, Rahel G Ghebre, Pearl M, Ramirez NC, Goodfellow P, Zighelboim I. Assessing the prognostic role of ATR mutation in endometrioid endometrial cancer: An NRG Oncology/ Gynecologic Oncology Group study. Gynecol Oncol. 2015 Jul 3. Pii: S0090-8258(15)30059-7. [Epub ahead of print]. PMID: 26144601. Angione SL, Oulhen N, Brayboy LM, Tripathi A, Wessel GM. Simple perfusion apparatus for manipulation, tracking, and study of oocytes and embryos. Fertil Steril. 2015 Jan;103(1):281-290.e5. [Epub 2014 Nov 20]. PMID: 25450296. Avanasi R, Shin HM, Vieira VM, Savitz DA, Bartell SM. Impact of exposure uncertainty on the association between perfluorooctanoate and preeclampsia in the C8 Health Project population. Environ Health Perspect. 2015 Jun 19. [Epub ahead of print] PMID: 26090912. Bailit JL, Grobman W, McGee P, Reddy UM, Wapner RJ, Varner MW, Thorp JM, Leveno KJ, Iams JD, Tita AT, Saade G, Sorokin Y, Rouse DJ, Blackwell SC; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. Does the presence of a condition-specific obstetric protocol lead to detectable improvements in pregnancy outcomes? Am J Obstet Gynecol. Feb 2015. [Epub ahead of print] PMID: 25659468. Bailit JL, Grobman WA, Rice MM, Reddy UM, Wapner RJ, Varner MW, Leveno KJ, Iams JD, Tita AT, Saade G, Rouse DJ, Blackwell SC; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Morbidly adherent placenta treatments and outcomes. Obstet Gynecol. 2015 Mar; 125(3): 683-9. PMID: 25730233. Belfort MA, Saade GR, Thom E, Blackwell SC, Reddy UM, Thorp JM Jr, Tita AT, Miller RS, Peaceman AM, McKenna DS, Chien EK, Rouse DJ, Gibbs RS, El-Sayed YY, Sorokin Y, Caritis SN, VanDorsten JP. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units (MFMU) Network. A randomized trial of intrapartum fetal ECG ST-segment analysis. N Engl J Med. 2015 Aug 13;373(7):632-41. PMID: 26267623.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

2013â&#x20AC;&#x201C;2014

Bernstein MH, McSheffrey SN, van den Berg JJ, Vela JE, Stein LA, Roberts MB, Martin RA, Clarke JG. The association between impulsivity and alcohol/drug use among prison inmates. Addict Behav. 2015 Mar;42-140-3. [Epub 2014 Nov 23]. PMID: 25462662. Blein S, Bardel C, Danjean V, McGuffog L, DiSilvestro PA, et al. An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers. Breast Cancer Res. 2015 Apr 25;17:61. PMID: 25925750. Brayboy LM, Wessel GM. The double-edged sword of the mammalian oocyte - advantages, drawbacks and approaches for basic and clinical single cell analysis. Mol Hum Reprod. 2015 Nov 19. [Epub ahead of print]. PMID: 26590170. Buery-Joyner SD, Dalrymple JL, Abbott JF, Craig LB, Forstein DA, Graziano SC, Hampton BS, Hopkins L, Page-Ramsey SM, Pradhan A, Wolf A, McKenzie ML. Overcoming Electronic Medical Record Challenges on the Obstetrics and Gynecology Clerkship. Obstet Gynecol. 2015 Sep;126(3):553-5589. PMID 26244540. Cantillo E, Rizack T. Therapeutic Molecular Biomarkers in Gynecological Cancers. RI Med J (2013). 2015 Nov 2;98(11):20-2. PMID: 26517250. Casey JA, Savitz DA, Rasmussen SG, Ogburn EL, Pollak J, Mercer DG, Schwartz BS. Unconventional natural gas development and birth outcomes in Pennsylvania, USA. Epidemiology. 2015 Sep 30. [Epub ahead of print] PMID:26426945.

Department. Addict Disord Their Treat. 2015 June; 14(2): 95-104. PMID: 26167133; PMCID: PMC 4498583. Christianson MS, Mensah VA, Shen W. Multiple sclerosis at menopause: Potential neuroprotective effects of estrogen. Maturitas. 2015 Feb;80(2):133-139. Epub 2014 Nov 27. PMID: 25544310. Clarke JG, Martin SA, Martin RA, Stein LA, van den Berg JJ, Parker DR, McGovern AR, Robers MB, Bock BC. Changes in smokingrelated symptoms during enforced abstinence of incarceration. J Health Care Poor Underserved. 2015 Feb;26(1):106-18. PMID: 25702731. Clark, MA, Gorelick JJ, Sicks JD, Park ER, Graham AL, Abrams DB, Gareen IF. The relations between false positive and negative screens and smoking cessation and relapse in the national lung cancer screen trial: Implications for public health. Nicotine Tob Res. 2015 Mar 6. [Epub ahead of print]. PMID: 25746779. Clark, MA, Ott M, Rogers ML, Politi MC, Miller SC, Moynihan L, Robison K, Stuckey A, Dizon D. Advance care planning as a shared endeavor: Completion of ACP documents in a multidisciplinary cancer program. Psychooncology. 2015 Oct 21. [Epub ahead of print]. PMID: 26489363. Cohen ID, Savulescu J, Adashi EY. Medicine. Transatlantic lessons in regulation of mitochondrial replacement therapy. Science. 2015 Apr 10;348(6231):178-80. [Epub 2015 Apr 9]. PMID: 25859028.

Chau DB, Ciullo SS, Watson-Smith D, Chun TH, Jurkchubasche AG, Luks FI. Patient-centered outcomes research in appendicitis in children: Bridging the knowledge gap. J Pediatr Surg 2015 Oct 22 [Epub ahead of print]. PMID: 26545589.

Cohn DE, Havrilesky LJ, Osann K, Lipscomb J, Hsieh S, Walker JL, Wright AA, Alvarez RD, Karlan BY, Bristow RE, DiSilvestro PA, Wakabayashi MT, Morgan R, Mukamel DB, Wenzel L. Consensus in controversy: The modified Delphi method applied to Gynecologic Oncology practice. Gynecol Oncol. 2015 Sep;138(3):712-6. [Epub 2015 Jul 12].PMID: 26177553.

Choo EK, Ranney ML, Wetle TF, Morrow K, Mello MJ, Squires D, Garro A, Tape C, Zlotnick C. Attitudes toward computer interventions for partner abuse and drug use among women in the Emergency

Conley LJ, Bush TJ, Darrach TM, Palefsky JM, Under ER, Patel P, Steinau M, Kojic EM, Martin H, Overten ET, Cu-Uvin S, Hammer J, Henry K, Wood K. Brooks JT; SUN Study Group. Incidence and

2015 Annual Report

Peer-Reviewed Publications

predictors of abnormal anal cytology findings among HIV-infected adults receiving contemporary antiretroviral therapy. J Infect Dis. 2015 Aug 12. [Epub ahead of print]. PMID: 26268855.

Dean LA, Adashi EY. Repealed and Replaced: SGR Gives Way to Value-based Medicare Payment Reform. Am J Med. 2015 Oct;128(10):1052-3. [Epub 2015 May 27]. PMID: 26021814.

Coustan DR. Costs of gestational diabetes. Diabet Med. 2015 Sep 11 doi: 10.111/dme.12961 [Epub ahead of print]. PMID: 26361358.

DePaepe ME, Shapiro S,Young LE, Luks FL. Placental weight, birth weight and fetal:placental weight ratio in dichorionic and monochorionic twin gestations in function of gestational age, cord insertion type and placental partition. Placenta. 2015 Feb;36(2):21320. [Epub 2014 Nov 22]. PMID: 25492576.

Coustan DR. Re: Follow-up of women with previous gestational diabetes. Acta Diabetol. 2015 Jun 27. [Epub ahead of print] PMID: 26112414. Coustan D. Response to Andiy Danyliv. Diabet Med. 2015. Oct 20. Doi:10.1111/dme.12995. [Epub ahead of print]. PMID: 26482118. Creech SK, Swift R, Zlotnick C, Taft CT, Street AE. Combat Exposure, Mental Health, and Relationship Functioning Among Women Veterans of the Afghanistan and Iraq Wars. Journal of Fam Psycol. Epub September 7, 2015. PMID: 26348108. Dahlke JD, Mendez-Figueroa H, Maggio L, Albright CM, Chauhan SP, Wenstrom KD. Early Term versus Term Delivery in the Management of Fetal Growth Restriction: A Comparison of Two Protocols. Am J Perinatol. 2015 May;32 (6): 523-30. [Epub 2014 Dec 29] PMID: 25545442. Danilack VA, Dore DD, Triche EW, Muri JH, Phipps MG, Savitz DA. The effect of labour induction on the risk of caesarean delivery: Using propensity scores to control confounding by indication. BJOG. 2015 Sep 28. doi: 10.1111/1471-0528.13682. [Epub ahead of print] PMID: 26411752. Danilack VA, Nunes AP, Phipps MG Unexpected complications of low-risk pregnancies in the United States. Am J Obstet Gynecol. 2015 Jun;212(6):809.e1-6. doi: 10.1016/j.ajog.2015.03.038. PMID: 26042957. Danilack VA, Okunbor O, Richardson CR, Teylan M, Moy ML. Performance of a pedometer to measure physical activity in U.S. cohort with chronic obstructive pulmonary disease. J Rehabil Res Dev 2015; 52(3):333â&#x20AC;&#x201C;42. PMID: 26230737. 46

Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Ager J, Huang H, Hansen KR, Baker V, Usadi R, Seungdamrong A, Bates GW, Rosen RM, Haisenleder D, Krawetz SA, Barnhart K, Trussell JC, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H; NICHD Reproductive Medicine Network. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. N Engl J Med. 2015 Sep 24;373(13):1230-40. PMID: 26398071. DiBiasio EL, Clark MA, Gozalo PL, Spence C, Casarett DJ, Teno JM. Timing of survey administration after hospice patient death: Stability of bereaved respondents. J Pain Symptom Manage. 2015 Jul;50(1):1727. [Epub 2015 Jan 31]. PMID: 25647420. Druacker CB, Johnson DM, Johnson NL, Kadeba MT, Mazurczyk J, and Zlotnick C. Rapid HIV testing and counseling for residents in domestic violence shelters. Women & Health. 2015; 55(3):334-52. PMID: 25738795; PMCID: PMC4401648. Dumont DM, Parker DR, Viner-Brown S, Clarke JG. Incarceration and perinatal smoking: A missed public health opportunity. J Epidemiol Community Health. 2015 Jul;69(7): 648-53. [Epub 2015 Feb 19]. PMID: 25700530. Dunn HK, Clark MA, Pearlman DN. The relationship between sexual history, bully victimization, and poor mental health outcomes among heterosexual and sexual minority high school students: A feminist perspective. J. Interpers Violence. 2015 Aug 12 {Epub ahead of print]. PMID: 26268273.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Ehsanipoor RM, Seligman NS, Saccone G. Szymanski LM, Wissinger C, Werner EF, Berghella V. Physical Examination-Indicated Cerclage: A Systematic Review and Meta-Analysis. Obstet Gynecol. 2015 Jul;126(1):125-35. PMID: 26241265. Fallon EA, Ha AY, Merck DL, Ciullo SS, Luks FI. Interactive instrument-driven image display in laparascopic surgery. J Laparendosc Adv Surg Tech A. 2015 Jun;25(6):531-5. [Epub 2015 May 5]. PMID: 25942694. Febbraro T, Robison K, Scalia Wilbur J, Laprise J, Bregar A, Lopes V, Legare R, Stuckey A. Adherence patterns to National Comprehensive Cancer Network (NCCN) guidelines for referral to cancer genetic professionals. Gynecol Oncol. 2015 Jul;138(1):109-14.. [Epub ahead of print 2015 Apr 28]. PMID: 25933682. Fiascone S, Datkhaeva I, Winer ES, Rizack T. Primary mediastinal large B-cell lymphoma in pregnancy. Leuk Lymphoma. 2015 Jun 18:14. [Epub ahead of print]. PMID: 25956044. Frishman G. Is it time to take a second look at second look laparoscopy? J Minim Invasive Gynecol. 2015 Mar 25. PMID: 25818377. Froehlich R, Simhan HN, Larkin JC. An Evidence Based Approach to Defining Macrosomia. Am J Perinatol.2015 Oct 25. [EPUB ahead of print]. PMID: 26499356. Gleason JL, Parden AM, Jauk V, Ballard A, Sung V, Richter HE. Outcomes of midurethral sling procedures in women with mixed urinary incontinence. Int Urogynecol J. 2015 May;26(5):715-20. [Epub 2015 Jan 10]. PMID: 25576468. Golshan M, Cirrincione C, Sikov WM, et al. Impact of neoadjuvant chemotherapy in stage II-III triple negative breast cancer on eligibility for breast conserving surgery and breast conservation rates: Surgical results from CALGB 40603 (Alliance). Ann Surg. 2015 Sept;262(3):434-9 discussion 438-9. PMID: 26222764.

Goodfellow PJ, Billingsley CC, Lankes HA, Ali S, Cohn DE, Broaddus RJ, Ramirez N, Pritchard CC, Hampel H, Chassen AS, Simmons LV, Schmidt AP, Gao F, Brinton LA, Backes F, Landrum LM, Geller MA, DiSilvestro PA, Pearl ML, Lele SB, Powell MA, Zaino RJ, Mutch D. Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers from GOG210: An MRG Oncology and Gynecologic Oncology Group Study. J Clin Oncol. 2015 Nov 9. [Epub ahead of print] PMID: 26552419. Grobman WA, Bailit JL, Rice MM, Wapner RJ, Reddy UM, Varner MW, Thorp JM Jr, Leveno KJ, Caritis SN, Iams JD, Tita AT, Saade G, Rouse DJ, Blackwell SC, Tolosa JE, VanDorsten JP; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Racial and ethnic disparities in maternal morbidity and obstetric care. Obstet Gynecol. June 2015. 125(6): 1460-7. PMID: 26000518. Hamel MS, Hughes BL, Rouse DJ. Whither oxygen for intrauterine resuscitation? Am J Obstet Gynecol. Apr 2015. 212(4): 461.e1-3. doi: 10.1016/j.ajog.2015.01.057. PMID: 25659471. Hampton BS, Craig LB, Abbott JF, Buery SD, Dalyrymple JL, Forstein DA, Hopkins L, McKenzie ML, Page-Ramsay S, Pradhan A, Wolf A, Graziano SC; For the APGO Undergraduate Medical Education Committee. To the Point: Teaching the Obstetrics and Gynecology Medical Student in the Operating Room. Am J Obstet Gynecol. April 2015. [Epub ahead of print] PMID: 25857571. Hampton BS, Kay A, Pilzek A. Urinary fistula and incontinence. Semin Reprod Med. 2015 Jan; 33(1):47-52. Epub 2015 Jan 7. PMID: 25565512. Han CS, Herrin MA, Pitruzzello MC, Flannery CA, Pettkey C, Werner EF, Abrahams VA. Glucose and metformin modulate human first trimester trophoblast function: A model and potential therapy for diabetes-associated uteroplacental insufficiency. Am J Reprod Immunol. 2015 Apr;73(4):362-71. [Epub 2014 Nov 14]. PMID: 25394884.

2015 Annual Report

Peer-Reviewed Publications

Hartnett EG, Cronin B. Cervical Cancer Screening: What Do I Need to Know? Update on Guidelines Changes and Review of Complications of Treatment. Postgraduate Obstet Gynecol. Feb 2015: Vol 35(4). Pgs 1-8. Hartwich J, Luks FI, Watson-Smith D, Kurkchubasche AG, Muratore CS, Wills HE, Tracy TF Jr. Nonoperative treatment of acute appendicitis in children: A feasibility study. J Pediatr Surg. 2015 Oct 23 [Epub ahead of print]. PMID: 26547287. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH; Reproductive Medicine Network (Alvero R, consortium member), Stener-Victorin E, Legro RS, Dunaif A. Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2015 Aug 18;6:7502. PMID: 26284813.

Hogue CJ, Parker CB, Willinger M, Temple JR, Bann CM, Silver RM, Dudley DJ, Moore JL, Coustan DR, Stoll BJ, Reddy UM, Varner MW, Saade GR, Conway D, Goldenberg RL; Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network Writing Group. The association of stillbirth with depressive symptoms 6-36 months post-delivery. Paediatr Perinat Epidemiol. 2015 Mar; 29(2): 131-43. PMID: 25682858. Howard ED, Jolles, D. 2015. Navigating the Perinatal Quality Landscape. J Perinat Neonatal Nurs. 2015 Apr-June; 29(2):116-29. PMID: 25919602. Hughes BL. Antibiotic prophylaxis in pregnancy: Benefit without harm? BJOG 2015 Sep 28. Doi: 10.111.1471-0528 [Epub ahead of print]. PMID: 26411525.

Hickey EA, Rouse DJ. Pregnancy and weight gain: We have observed enough. Obstet Gynecol. Apr 2015. 125(4): 771-2. doi: 10.1097. PMID: 25751225.

Jelovsek JE, Markland AD, Whitehead WE, Barber MD, Newman DF, Rogers RG, Dyer K, Visco A, Sung VW, Sutkin G. Meikle SF, Gantz MG for the PFDN. Controlling anal incontinence in women by performing anal exercises with biofeedback or loperamide (CAPABLe) trial: Design and methods. Contemp Clin Trials. 2015 Aug 17. PMID: 26291917.

Hill EK, Blake RA, Emerson JB, Svider P, Eloy JA, Raker C, Robison K, Stuckey A. Gender Differences in Scholarly Productivity Within Academic Gynecologic Oncology Departments. Obstet Gynecol. 2015 Nov 5 [Epub ahead of print]. PMID: 26551177.

Johnson JE, Williams C, and Zlotnick C. Development and feasibility of a cell phone-based transitional intervention for women prisoners with comorbid substance use and depression. Prison J. 2015 Sep;95(3):330-352. [Epub 2015 Jun1]. PMID: 26508805.

Hirtz DG, Weiner SJ, Bulas D, DiPietro M, Seibert J, Rouse DJ, Mercer BM, Varner MW, Reddy UM, Iams JD, Wapner RJ, Sorokin Y, Thorp JM Jr, Ramin SM, Malone FD, Carpenter MW, O’Sullivan MJ, Peaceman AM, Hankins GD, Dudley D, Caritis SN. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. Antenatal magnesium and cerebral palsy in preterm infants. J Pediatr. 2015 Oct;167(4):834-839.e3. doi: 10.1016/j.jpeds.2015.06.067. [Epub 2015 Aug 5]. PMID: 26254839.

Joseph AM, Adashi EY. Health CO-OPs of the Affordable Care Act: Promise and Peril at the 5-Year Mark. JAMA. 2015 Apr 14;313 (14):1419-1420. PMID: 25633925.

Kao J, Johnson J, Todorova R, Zlotnick C. The positive effect of a group intervention to reduce postpartum depression on breastfeeding outcomes in low-income women. Int J Group Psychother. 2015 Jul; 65(3):445-58. PMID: 26076207; PMCID: PMC4470302.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Kuang H, Jin S, Thomas T, Engmann L, Hansen KR, Coutifaris C, Casson P, Christman G, Alvero R, Santoro N, Eisenberg E, Diamond MP, Legro RS, Zhang H; Reproductive Medicine Network. Predictors of participant retention in infertility treatment trials. Fertil Steril. 2015 Sep 3. PMID: 26354094. Kuang H, Jin S, Hansen KR, Diamond MP, Coutifaris C, Casson P, Christman G, Alvero R, Huang H, Bates GW, Usadi R, Lucidi S, Baker V, Santoro N, Eisenberg E, Legro RS, Zhang H; Reproductive Medicine Network. Identification and replication of prediction models for ovulation, pregnancy and live birth in infertile women with polycystic ovary syndrome. Hum Reprod. 2015 Sep;30(9):2222-33. [Epub 2015 Jul 22]. PMID: 26202922.

Ligibel JA, Cirrincione CT, Liu M, Citron M, Ingle JN, Gradishar W, Martino S, Sikov W, Michaelson R, Mardis E, Perou CM, Ellis M, Winer E, Hudis CA, Berry D, Barry WT. Body Mass Index, PAM50 Subtype, and Outcomes in Node-Positive Breast Cancer: CALGB 9741 (Alliance). J Natl Cancer Inst. 2015 Jun 25;107(9). PMID: 26113580. Liu XM, Chan HC, Ding GL, Cai J, Song Y, Wang TT, Zhang D, Chen H, Yu MK, Wu YT, Qu F, Liu Y, Lu YC, Adashi EY, Sheng JZ, Huang HF (2015). FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca2+ /CREB pathway. Aging Cell. 2015 Jun;14(3)409-20. PMID: 25754247.

Kuchenbaecker KB, Ramus SJ, Tyrer J, Lee A, DiSilvestro PA, et al. Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet. 2015 Feb;47(2):164-71. [Epub 2015 Jan 12]. PMID: 25581431.

Lokich E, Palisoul M, Romano N, Miller CM, Robison K, Stuckey A, DiSilvestro P, Mathews C, Granai CO, Lambert-Messerlian G, Moore RG. Assessing the Risk of Ovarian Malignancy Algorithm for the Conservative Management of Women with a Pelvic Mass. Gynecol Oncol. 2015 Sep 11. [Epub ahead of print]. PMID: 26364809.

Kunkle CM, Hallock JL, Hu X, Blomquist J, Thung SF, Werner EF. Cost utility analysis of urethral bulking agents versus midurethral sling in stress urinary incontinence. Female Pelvic Med Reconstr Surg. 2015 May-Jun;21(3):154-9. PMID: 25730435.

Lopez M, Bernholc A, Zeng Y, Allen RH, Bartz D, O’Brien PA, Hubacher D. Interventions for pain with intrauterine device insertion. Cochrane Database of Syst Rev 2015. July 29;7:CD007373 [Epub ahead of print] PMID: 26222246.

Kuritzky B, Sikov WM. How high a bar to change neoadjuvant therapy for triple-negative breast cancer? J Comp Eff Res. 2015;4(4):293-6. PMID: 26274790.

Loveless M, Amies Oelschlager AM, Browner-Elhanan KJ, Evans Y, Huguelet PS, Karjane NW, Laul P, Talib HJ, Wheeler C, Fleming N. Long Curriculum in Resident Education. J Pediatr Adolesc Gynecol. 2015 Jun;28(3):196-206. [Epub 2015 Jun 2]. PMID: 26123870.

Lantini R, van den Berg JJ, Roberts MB, Bock BC, Stein LA, Parker DR, Friedmann PD, Clarke JG. Characteristics of smoking used cigarettes among an incarcerated population. Psychol Addict Behav. 2015 Mar;29(1):254-8. [Epub 2014 Sept 1]. PMID: 25180554. Lewis RC, Evenson KR, Savitz DA, Meeker JD. Temporal variability of daily personal magnetic field exposure metrics in pregnant women. J Expo Sci and Environ Epidemiol. 2015 Jan;25(1):58-64. doi: 10.1038/ jes.2014.18. Epub 2014 Apr 2. PMID: 24691007.

Luks FI. Re: Fetal intervention for severe lower urinary tract obstruction: A multicenter case-control study comparing fetal cystoscopy with vesicoamniotic shunting. R. Ruano, N. Sanaes, H. Sangi-Haghpeykar, S. Hernandez-Ruano, R. Moog, F. Becmeur, A. Zaloszyc, A.M. Giron, B. Morin and R. Favre. Ultrasound Obstet Gynecol 2015;45:452-458. Ultrasound Obstet Gynecol. 2015 Apr;45(4):375-6. PMID: 25833370. Luks FI, Johnson A, Polzin WJ, North American Fetal Therapy Network. Innovation in maternal-fetal therapy: A position statement 2015 Annual Report

Peer-Reviewed Publications

from the North American Fetal Therapy Network. Obstet Gynecol. 2015 Mar;125(3):649-52. PMID: 25730229. Lum LG, Thakur A, Al-Kadhimi Z, Colvin GA, Cummings FJ, Legare RD, Dizon DS, Kouttab N, Maizel A, Colaiace W. Liu Q, Rathore R. Targeted T-cell Therapy in Stage IV Breast Cancer: A Phase I Clinical Trial. Clin Cancer Res. 2015 May 15;21(10):2305-14. [Epub 2015 Feb 16]. PMID: 25688159.

C. The metabolic profile of intrahepatic cholestasis of pregnancy is associated with impaired glucose tolerance, dyslipidemia, and increased fetal growth. Diabetes Care. 2015 Feb;38(2):243-8. [Epub 2014 Dec 12]. PMID: 25504029.

Maggio L, Carr SR, Watson-Smith D, O’Brien BM, Lopes V, Muratore CS, Luks FI. Iatrogenic Preterm Premature Rupture of Membranes after Fetoscopic Laser Ablative Surgery. Fetal Diagn Ther. 2015;38(1):29-34. [Epub 2014 Nov 22]. PMID: 25427832. Maggio L, Dahlke JD, Mendez-Figueroa H, Albright CM, Chauhan SP, Wenstrom KD. Perinatal Outcomes with normal compared with elevated umbilical artery systolic-to-diastolic ratios in fetal growth restriction. Obstet Gynecol. Apr 2015. 125(4): 863-9. doi: 10.1097. PMID: 25751217. Maggio L, Nicolau DP, DaCosta M, Rouse DJ, Hughes BL. Cefazolin prophylaxis in obese women undergoing cesarean delivery: A randomized controlled trial. Obstet Gynecol. 2015 May; 125(5): 1205-10. PMID: 25932849. Mainiero AD, Rouse DJ, Lopes V, Hughes BL. Association of 17 α-Hydroxyprogesterone Caproate and Risk of Infection. Obstet Gynecol. 126(1):103-108, July 2015. PMID: 26241262. Mandelberger AH, Robins JC, Buster JE, Strohsnitter WC, Plante BJ. Preconception counseling: Do patients learn about genetics from their obstetrician gynecologists? J Assist Reprod Genet. 2015 Jun 9. [Epub ahead of print] PMID: 26050996. Marrero S, Adashi EY. Noncommunicable diseases. Semin Reprod Med. 2015 Jan;33(1):35-40. PMID: 25565510.

Matteson KA, Scott DM, Raker CA, Clark MA. The menstrual bleeding questionnaire: Development and validation of a comprehensive patient-reported outcome instrument for heavy menstrual bleeding. BJOG. 2015 Apr;122(5):681-9. PMID: 25615842. Mayhall EA, Gray R, Lopes V, Matteson KA. Comparison of antiemetics for nausea and vomiting of pregnancy in an emergency department setting. Am J Emerg Med. 2015 Jul;33(7):882-6. [Epub 2015 Mar 18]. PMID: 25921968. McCoin ML, Flores VA, Wheeler CA, Lopes V, Matteson KA. Influence of clinical history and demographic factors on infertility patients’ willingness to participate in clinical research. Edorium J Clin Res. 2015;1:1–7. McDonough JE, Adashi EY. In defense of the employer mandate: Hedging against uninsurance. JAMA 2015 Feb 17;313(7)”655-6. PMID: 25521209. Mendez-Figueroa H, Chauhan SP, Pedroza C, Refuerzo JS, Dahlke JD, Rouse DJ. Preterm cesarean delivery for nonreassuring fetal heart rate: Neonatal and neurologic morbidity. Obstet Gynecol. 2015 Mar;125(3): 636-42. PMID: 25730227.

Martineau MG, Raker C, Dixon PH, Chambers J, Machirori M, King NM, Hooks ML, Monaharan R, Chen K, Powrie R, Williamson 50

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

McMeekin DS, Sill MW, Walker JL, Moore KN, Waggoner SE, Thaper PH, Rizack T, Hoffman JS, Fracasso PM. A phase I study of IV doxorubicin plus intraperitoneal (IP) paclitaxel and IV or IP cisplatin in endometrial cancer patients at high risk for peritoneal failure (GOG 9920): An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2015 Jul’138(1):36-40. [Epub 2015 May 6]. PMID: 25958319. Mehta N, Chen K, Hardy E, Powrie R. Respiratory disease in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2015 Jul;29(5):598611. [Epub 2015 Apr 20]. PMID: 25997564. Miller R, Smiley R, Thom E, Grobman W, Iams J, Mercer B, Saade G, Tita A, Reddy U, Rouse D, Sorokin Y, Blackwell S, Esplin M, Tolosa J, Caritis S; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. The association of beta-2 adrenoceptor genotype with short-cervix mediated preterm birth: A case-control study. BJOG. 2015 Jan. doi: 10.1111/1471-0528.13243. [Epub ahead of print] PMID: 25600430. Myers DL. Bariatric Surgery and Urinary Incontinence. JAMA Intern Med. 2015 Aug 1;175(8):1387-8. PMID: 26098294. Norwitz ER, Bonney EA, Snegovskikh VV, Williams MA, Phillippe M, Park JS, Abrahams VM. Molecular Regulation of Parturition: The Role of the Decidual Clock. Cold Spring Harb Perspect Med. 2015 Apr 27. [Epub ahead of print]. PMID: 25918180. Olson G, Weiner SJ, Rouse DJ, Reddy UM, Mercer BM, Varner MW, Leveno KJ, Iams JD, Wapner RJ, Ramin SM, Malone FD, Carpenter MW, O’Sullivan MJ, Dinsmoor MJ, Hankins GD, Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. Relation Between Birth Weight and Weight and Height at the Age of 2 in Children Born Preterm. Am J Perinatol. 2015 May; 32(6): 591-8. PMID: 25730133.

Onstad M, Stuckey A. Hereditary Breast Cancer: An update on risk assessment and genetic testing in 2015. Am J Obstet Gynecol. 2015 Mar 3. [Epub ahead of print]. PMID: 25747548. Palatnik A, Mele L, Landon MB, Reddy UM, Ramin SM, Carpenter MW, Wapner RJ, Varner MW, Rouse DJ, Thorp JM Jr, Sciscione A, Catalano P, Saade GR, Caritis SN, Sorokin Y; Eunice Kennedy Shriver National Institute of Child Health and Human Development MaternalFetal Medicine Units (MFMU) Network; Timing of Treatment Initiation for Mild Gestational Diabetes and Perinatal Outcomes. Am J Obstet Gynecol. June 201. [Epub ahead of print]. PMID: 26071920. Palatnik A, Rouse DJ, Stamilio DM, McPherson JA, Grobman WA. Association Between Cerebral Palsy or Death and Umbilical Cord Blood Magnesium Concentration. Am J Perinatol. June 2015. . [Epub ahead of print]. PMID: 26058371. Parker DR, Eltinge S, Rafferty C, Eaton CB, Clarke JG, Goldman RE. Primary care providers’ views on using lung age as an aid to smoking cessation counseling for patients with chronic obstructive pulmonary disease. Lung. 2015 Jun;193(3):321-7. [Epub 2015 Mar 20]. PMID: 25791068. Parker DR, Roberts MD, van den Berg JJ, Bock B, Stein LA, Martin RA, Clarke JG. Exploration of incarcerated men’s and women’s attitudes of smoking in the presence of children and pregnant women: Is there a disparity between smoking attitudes and smoking behavior? Nicotine Tob Res. 2015 May 25. [Epub ahead of print]. PMID: 26014453. Pearce MM, Zilliox MJ, Thomas-White KJ, Richter HE, Nager CW, Cisco AG, Nygaard IE, Barber MD, Schaffer J, Moalli P, Sung VW, Smith AL, Rogers R, Nolen TL, Wallace D, Meikle SF, Gai X, Wolfe AJ, Brubaker L; Pelvic Floor Disorders Network. The female urinary microbiota in urgency urinary incontinence. Am J Obstet Gynecol. 2015 Jul 23. Pii:S0002-9378(15)00745-0 [Epub ahead of print]. PMID: 26210757.

2015 Annual Report

Peer-Reviewed Publications

Pradhan A, Page-Ramsey S, Buery-Joyner SD, Craig LB, Dalrymple JL, Forstein DA, Graziano S, Hampton BS, Hopkins L, McKenzie M, Wolk A, Abbott JB. Undergraduate Obstetrics and Gynecology Medical Education: Why Are We Underrated and Underappreciated? Am J Obstet Gynecol. 2015 Oct 29. [Epub ahead of print]. PMID: 26522859. Radoff K, Natch A, McConaughey E, Salstrom J, Schelling K, Seger S. Midwives in Medical Student and Resident Education and the Development of the Medical Education Caucus Toolkit. J Midwifery Womens Health. 2015 May;60(3):304-12. [Epub 2015 May 15]. PMID: 25980324. Ramaswamy M, Chen HF, Cropsey KL, Clarke JG, Kelly PJ. Highly effective birth control use before and after women’s incarceration. J Womens Health (Larchmt). 2015 Jun;24(6):530-9. [Epub 2015 Jan 2]. PMID: 25555175. Rana AI, Liu T, Gillani FS, Reece R, Kojic EM, Zlotnick C, and Wilson IB. Multiple gaps in care common among newly diagnosed HIV patients. AIDS Care. 2015; 27(6):679-687. PMID: 25634492; PMCID: PMC4366312. Reddy UM, Rice MM, Grobman WA, Balilt JK, Wapner RJ Varner MW, Thorp JM Jr, Leveno KJ, Caritis SN, Prasad M, Tita AT, Saade GR, Sorokin Y, Rouse DJ, Blackwell SC, Tolosa JE. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. Serious maternal complications after early preterm delivery (24-33 weeks’ gestation). Am J Obstet Gynecol. 2015 Oc;213(4):538e1-9. [Epub 2015 Jul 9] PMID: 26164696. Rich JD, Adashi EY. Ideological Anachronism Involving Needle and Syringe Exchange Programs: Lessons from the Indiana HIV Outbreak. JAMA. 2015 Jul 7;314(1):23-4. PMID: 26000661. Rich JD, McKenzie M, Larney S, Wong JB, Tran L. Clarke J, Noska A, Reddy M, Zaller N. Methadone continuation versus forced withdrawal on incarceration in a combined US prison and jail: A randomized,

open-label trial. Lancet. 2015 Jul 25,386(99991):350-9. [Epub 2015 May 28]. PMID: 26028120. Richter HE, Whitehead N, Arya L, Ridgeway B, Allen-Brady K, Norton P, Sung V, Shepherd JP, Komesu Y, Gaddis N, Fraser M, Tan-Kim J, Meikle S, Page GP, Pelvic Floor Disorders Network. Genetic contributions to urgency urinary incontinence in women. J Urol. 2015;193(6):2020-2027. PMID: 25524241. Robison K, Cronin B, Bregar A, Luis C, DiSilvestro P, Schechter S, Pisharodi L, Raker C, Clark MA. Anal cytology and HPV genotyping in women with a history of lower genital tract neoplasia compared to women without a history of lower genital tract neoplasia. Obstet Gynecol. 2015 Nov 5. [Epub ahead of print]. PMID: 26551180. Roque DR, Robison K, Raker CA, Wharton GG, Frishman GN. The accuracy of surgeons’ provided estimates for the duration of hysterectomies: A pilot study. J Minim Invasive Gynecol. 2015 Jan;22(1):57-65. [Epub 2014 Jul 11]. PMID: 25020086. Rose PG, Java J, Whitney CW, Stehman FB, Lanciano R, Thomas GM, DiSilvestro PA. Nomograms Predicting Progression-Free Survival, Overall Survival, and Pelvic Recurrence in Locally Advanced Cervical Cancer Developed From an Analysis of Identifiable Prognostic Factors in Patients from NRG Oncology/Gynecologic Oncology Group Randomized Trials of Chemoradiotherapy. J Clin Oncol. 2015 Jul 1;33(19):2136-42. [Epub 2015 Mar 2]. PMID: 25732170. Rouse DJ. Prophylactic negative pressure wound therapy: We need proof before application. Obstet Gynecol. Feb 2015; 125 (2): 297-8. PMID: 25569011. Santhakumar S, Adashi EY. The Physician Payment Sunshine Act: Testing the value of transparency. JAMA. 2015 6;313(1):23-4. PMID: 25473969. Sau MS, Balamane M, Lurie M, Harwell J, Welle E. Mean C, CuUvin S. Assessment of Prevention of Mother-to-Child Transmission

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

HIV Services in the Bantey Meanchey Province in Cambodia. J Int Assoc Provid AIDS Care. 2015 Sept 3. [Epub ahead of print]. PMID: 26337679. Savitz DA, Elston B, Bobb JF, Clougherty JE, Dominici F, Ito K, Johnson S, McAlexander T, Ross Z, Shmool JL, Matte TD, Wellenius GA. Ambient fine particulate matter, nitrogen dioxide, and hypertensive disorders of pregnancy in New York City. Epidemiology. 2015 Sep;26(5):748-57. PMID: 26237745. Savitz DA, Fell DB, Ortiz JR, Bhat N. Does influenza vaccination improve pregnancy outcome? Methodological issues and research needs. Vaccine. 2015 Aug 28. pii: S0264-410X(15)01168-8. doi: 10.1016/j.Vaccine.2015.08.041. PMID: 26319740. Savitz DA, Werner EF. Invited commentary: Isolating preterm birth to assess its impact. Am J Epidemiol. 2015 Sep 25. Pii: kwv166. [Epub ahead of print]. PMID: 26409236. Shmool JL, Bobb JF, Ito K, Elston B, Savitz DA, Ross Z, Matte TD, Johnson S, Dominici F, Clougherty JE. Area-level socioeconomic deprivation, nitrogen dioxide exposure, and term birth weight in New York City. Environmental Research. 2015 Aug 26;142:624-632. doi: 10.1016/j.envres.2015.08.019. PMID: 26318257. Shaw JS, Jeppson PC, Rardin CR. Decreasing transobturator sling groin pain without decreasing efficacy using TVT-Abbrevo. Int Urogynecol J. 2015 Sep;26(9):1369-72. PMID: 26032699. Siddiqui NY, Grimes CL, Casiano ER, Abed HT, Jeppson PC, Olivera CK, Sanses TV, Steinberg AC, South MM, Balk EM, Sung VW; Society of Gynecologic Surgeons Systematic Review Group. Mesh sacrocolpopexy compared with native tissue vaginal repair: A systematic review and meta-analysis. Obstet Gynecol. 2015 Jan;125(1):44-55. PMID: 25560102. Sikov WM, Berry DA, Perou CM, Singh B, Cirrincione CT, Tolaney SM, Kuzma CS, Pluard TJ, Somlo G, Port ER, Golshan M. Bellon JR, Collyar D, Hahn OM, Carey LA, Hudis CA, Winer EP. Impact

of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II and III triple-negative breast cancer: CALCB 40603 (Alliance). J Clin Oncol. 2015 Jan 1;33(1):13-21. [Epub 2014 Aug 4]. PMID: 25092775. Sikov WM. I will recommend a clinical trial â&#x20AC;&#x201C; If I can. Am Soc Clin Oncol Educ Book. 2015;35:44-6. PMID: 25993141. Sikov WM. Assessing the role of platinum agents in aggressive breast cancers. Curr Oncol Rep. 2015 Feb;17(2):3. Review. PMID: 25665554. Singer J, Fiascone S, Huber WJ, Hunter T, Sperling J. Four Residentsâ&#x20AC;&#x2122; Narratives on Abortion Training: A Residency Climate of Reflection, Support, and Mutual Respect. Obstet Gynecol. 2015 July 126(1):55-60. PMID: 26241256. Sperling JD, Dahlke JD, Huber WH, Sibai BM. The Role of Headache in the Classification and Management of Hypertensive Disorders in Pregnancy. Obstet Gynecol. 2015 August; 126(2):297302. PMID. 26241418. Stein LA, Clair M, Rossi JS, Martin RA, Cancilliere MK, Clarke JG. Gender, ethnicity and race in incarcerated and detained youth: Services and policy implications for girls. Psychiatr Rehabil J. 2015 Mar;38(1):65-73. [Epub 2014 Sep 1]. PMID: 25180525. Steinhardt L. Workshop for New Leaders - Innovative Midwifery Teaching for Obstetrical and Gynecological Residents. J Midwifery Womens Health. 2015 May 8. [Epub ahead of print]. PMID: 25959237. Steiner AZ, Diamond MP, Legro RS, Schlaff WD, Barnhart KT, Casson PR, Christman GM, Alvero R, Hansen KR, Geisler WM, Thomas T, Santoro N, Zhang H, Eisenberg E; Reproductive Medicine Network. Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubes. Fertil Steril. 2015 Sep 25. [Epub ahead of print]. PMID: 26413816.

2015 Annual Report

Peer-Reviewed Publications

Stuckey AR, Onstad MA. Hereditary Breast Cancer: An update on risk assessment and genetic testing in 2015. Am J Obstet Gynecol. 2015 Aug;213(2):161-5. Mar 3. [Epub 2015 Mar 3]. PMID: 25747548. Stuebe AM, Landon MB, Lai Y, Klebanoff M, Ramin SM, Wapner RJ, Varner MW, Rouse DJ, Sciscione A, Catalano P, Saade G, Sorokin Y, Peaceman AM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. Is There a Threshold Oral Glucose Tolerance Test Value for Predicting Adverse Pregnancy Outcome? Am J Perinatol. 2015 Jan. PMID: 25594222. [Epub ahead of print]. PMID: 25594222. Tower AM, Cronin B. Myomectomy after a vaginal delivery to treat postpartum hemorrhage resulting from an intracavitary leiomyoma.Â Obstet Gynecol. 2015 Mar 9. [Epub ahead of print]. PMID: 25774928. Usadi RS, Diamond MP, Legro RS, Schlaff WD, Hansen KR, Casson P, Christman G, Wright Bates G, Baker V, Seungdamrong A, Rosen MP, Lucidi S, Thomas T, Huang H, Santoro N, Eisenberg E, Zhang H, Alvero R; Reproductive Medicine Network. Recruitment strategies in two Reproductive Medicine Network infertility trials. Contemp Clin Trials. 2015 Sep 16. [Epub ahead of print]. PMID: 26386293. Varadan V, Kamalakaran S, Gilmore H, Ganerjee N, Janevski A, Miskimen KL, Williams N, Basavanhalli A, Madabhushi A, LezonGeyda K, Bossuty V, Lannin DR, Abu-Khalaf M, Sikov W, Dimitrova N, Harris LD. Brief-exposure to preoperative bevacizumab reveals a TFG-Î˛ signature predictive of response in HER2-negative breast cancers. Int J Cancer. 2015 Aug 18. [Epub ahead of print]. PMID: 26284485. Washington BB, Raker CA, Kabeja GA, Kay A, Hampton BS. Demographics and delivery characteristics associated with obstetrics fistula in Kigali, Rwanda. Int J Gynaecol Obstet. 2015 Apr;129(1):34-7. [Epub 2014 Dec 6]. PMID: 25497047.

Washington CI, Jamshidi R, Thung SF, Nayeri UA, Caughey AB, Werner EF. Timing of postpartum intrauterine device placement: A cost-effectiveness analysis. Fertil Steril. 2015 Jan;103(1):131-7. {Epub 2014 Oct 25]. PMID: 25439838. Wenstrom KD. Screening for Rh c Alloimmunisation at 27 Weeks: Not Yet Convinced. Br J Obstet Gynaecol. 2015. in press. Werner EF, Braun JM, Yolton K, Khoury JC, Lanphere DP. The association between maternal urinary phthalate concentrations and blood pressure in pregnancy: The HOME Study. Environ Health. 2015 Sept 17;14(1):75. PMID: 26380974. Werner EF, Hamel MS, Orzechowski K, Berghella V, Thung SE. Cost-Effectiveness of Transvaginal Ultrasound Cervical Length Screening in Singletons without a Prior Preterm Birth: An Update. Am J Obstet Gynecol. 2015 Jun 10. [Epub ahead of print]. PMID: 26071914. Werner EF, Hausperg A, Rouse D. Costs of low-dose aspirin to prevent preeclampsia. Obstet Gynecol. 2015 Nov 5 [Epub ahead of print]. PMID: 26551178. Williams ST, Doody KJ, Schattman GL, Adashi EY. Public Reporting of Assisted Reproductive Technology Outcomes: Past, Present, and Future. Am J Obstet Gynecol. 2015 Feb;212(2):157-62. PMID: 24813599. Witherby S, Rizack T, Sakr BJ, Legare RD, Sikov WM. Advances in medical management of early stage and advanced breast cancer: 2015. Seminars in Radiation Oncology. Accepted August 2015. Zlotnick C, Tzilos G, Miller I, Seifer R, Stout R. Randomized controlled trial to prevent postpartum depression in mothers on public assistance. J Affect Disord. 2015 Sept 30;189:263-268. [Epub ahead of print]. PMID: 26454186.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Other Publications

Allen RH, Cwiak C, Kaunitz A. Progestin injectable contraceptive. The Handbook of Contraception: A Guide to Practical Management. Springer. New York, New York. 2015.

Rizack T, Perez K, Strenger R. Special Hematological Issues in the Pregnant Patient. Medical Management of the Pregnant Patient: A Clinician’s Handbook, K Rosene-Montella (ed). Springer 2015.

Allen RH, Hickey M, Kaunitz Am. Hormonal contraceptives. Williams Textbook of Endocrinology. Thirteenth Edition. Elsevier. 2015.

Rouse DJ. ACOG Update: Managing Normal and Abdominal Labor in the 21st Century. Volume 40; No. 10. Publication Date: April 1, 2015. Published in www.acogupdate.com.

Bishop K and Rizack T. Oncologic Emergencies. Principles and Practice of Hospital Medicine. McGraw-Hill, ACP 2nd edition: McKean, Ross, Dressler, Scheurer eds. Fall 2015. Browning K, Flores V, Robison K. Salpingectomy for Sterilization: A new standard of care? Postgraduate Obstetrics and Gynecology. 2015 July;35(14):1-5. Dizon D and Rizack T. Section Editors Oncology. Principles and Practice of Hospital Medicine, McGraw- Hill, ACP 2nd edition: McKean, Ross, Dressler, Scheurer eds. Fall 2015.

Sokol ER., Rardin, C. Expert tips on retropubic vs. transobturator sling approaches. Ob.Gyn News Digital Network. February 2015. Vigliani MB and Bakardjiev AI. Intracellular organisms as placental invaders. Fetal and Maternal Medicine Review, Available on CJO 2015. doi:10.1017/S0965539515000066. (http://journals.cambridge. org/abstract_ S0965539515000066) Vrees, R. Colon Cancer Screening: A Clinical Update for the Obstetrician/Gynecologist. Postgraduate Obstetrics and Gynecology. October 2015, Volume 35 –Issue 19.

Hampton B, contributing author, APGO Medical Student Objectives Teaching Cases, Association of Professors of Gynecology and Obstetrics, Crofton, MD.

Villavicencio J, Vrees R. Challenging Cases in Ob/Gyn. Office Diagnosis of Child Sexual Abuse (in press).

Hampton B, lead contributor, Ob/Gyn Student Log Book, Association of Professors of Gynecology and Obstetrics, Crofton, MD.

Wenstrom KD. Cardiac Disease. Protocols in High Risk Pregnancy. 6th edition. Queenan JT, Hobbins JC, Spong CY, editors. 2015.

Huber WJ, Frishman GN. Ovarian Ectopic Pregnancy. Ectopic Pregnancy: A Clinical Casebook. Ed. Tulandi T. New York: Springer, 2015 April, 93-99.

Publication as part of the U.S. Preventive Services Task Force (Phipps, MG)

Prager S, Allen RH, Dalton VK. American College of Obstetricians and Gynecologist Practice Bulletin: Early Pregnancy Loss. ACOG, May 2015. Rardin, CR. Dos and don’ts for handling common sling complications. OBGYN News. April 2015.

LeFevre ML; U.S. Preventive Services Task Force. Screening for thyroid dysfunction: U.S. Preventive Services Task Force recommendation statement. Annals of Internal Medicine. 2015 May 5;162(9):641-50. PMID: 25798805. Siu AL; U.S. Preventive Services Task Force. Screening for Speech and Language Delay and Disorders in Children Aged 5 Years or Younger: U.S. Preventive Services Task Force recommendation statement. Pediatrics. 2015 Aug;136(2):e474-81. [Epub 2015 Jul 7]. PMID: 26152670. 2015 Annual Report

Editorial Positions

PUBLICATION

POSITION

DATES OF SERVICE

FACULTY

American Journal of Epidemiology

Associate Editor

2012–Present

Savitz

American Journal of Obstetrics and Gynecology

Associate Editor

2007–Present

Phipps

American Journal of Obstetrics and Gynecology

Advisory Board

2002–Present

Wenstrom

American Journal of Perinatology

Editorial Board

2001–Present

Wenstrom

Clinical Medicine – Case Reports

Editorial Board

2008–Present

Alvero

Contraceptive and Reproductive Medicine

Editorial Board

2014–Present

Allen

Environmental Health Perspectives

Editorial Board

2009–Present

Savitz

Fertility and Sterility

Editorial Board

2013–Present

Buster

Fetal Diagnosis and Therapy

Associate Editor

2015

Luks

International Journal of Women’s Health and Wellness

Editorial Board

2015–Present

Moore

Journal of Gynecology Research

Editorial Board

2014–Present

Moore

Journal of Maternal-Fetal and Neonatal Medicine

Editorial Board

2002–Present

Coustan

Journal of Midwifery and Women’s’ Health

Contributing Editor

2011–Present

Hunter

Journal of Women’s Health & Gynecology

Editorial Board

2014–Present

Moore

Obstetrical and Gynecological Survey

Editorial Board

2013–Present

Hughes (Anderson)

Obstetrics and Gynecology, Ferri’s Clinical Advisor, Elsevier/Mosby Publications

Section Editor

2007–Present

Alvero

Obstetrics and Gynecology

Associate Editor

2013–Present

Rouse

Postgraduate Obstetrics and Gynecology

Associate Editor

2013–Present

Hampton

Reproductive Medicine Insights

Editorial Board

2008–Present

Alvero

The Journal of Minimally Invasive Gynecology (formerly Journal of the AAGL)

Contributing Editor Deputy Editor

2008–2012 2012–Present

Frishman

The Journal of Minimally Invasive Gynecology (formerly Journal of the AAGL)

Editorial Board

2010–Present

Rardin

The Obstetrician and Gynaecologist (TOG)

International Editorial Board

2013–Present

Matteson

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Contact Information

Women & Infants Hospital of Rhode Island 101 Dudley Street Providence, RI 02905 womenandinfants.org Maureen G. Phipps, MD, MPH Department of Obstetrics & Gynecology Chair mphipps@wihri.org (401) 274-1122, ext. 41575 Chris Fruggiero, MHA Director, Administrative Operations cfruggiero@wihri.org (401) 274-1122, ext. 41577 Kathy Farnum Executive Secretary kfarnum@wihri.org (401) 274-1122, ext. 41575 Denise Flinn Senior Project Coordinator dflinn@wihri.org (401) 274-1122, ext. 41578

Ruben Alvero, MD Reproductive Endocrinology and Infertility Division Director ralvero@wihri.org Renee Eger, MD Women’s Primary Care Center (Ambulatory Care) Medical Director reger@wihri.org Gary Frishman, MD Medical Education Director, Residency Program gfrishman@wihri.org Jennifer Gass, MD Breast Health Center Co-Director jgass@wihri.org C.O. (Skip) Granai III, MD Gynecologic Oncology Division Director sgranai@wihri.org Elisabeth Howard, PhD, CNM Midwifery Interim Division Director ehoward@wihri.org Robert D. Legare, MD Breast Health Center Co-Director rlegare@wihri.org

Deborah L. Myers, MD Urogynecology and Reconstructive Pelvic Surgery Division Director dmyers@wihri.org James O’Brien, MD Inpatient Obstetrics Medical Director jobrien@wihri.org Charles Rardin, MD Minimally-Invasive and Robotic Surgical Services Director crardin@wihri.org Roxanne Vrees, MD Emergency Obstetrics & Gynecology Medical Director rvrees@wihri.org Katharine Wenstrom, MD Maternal-Fetal Medicine Division Director kwenstrom@wihri.org Gary Wharton, MD Surgical Services Medical Director gwharton@wihri.org Kyle Wohlrab, MD Simulation Center Co-Director kwohlrab@wihri.org

Kristen A. Matteson, MD, MPH Clinical Research in Women’s Health Interim Division Director kmatteson@wihri.org 2015 Annual Report