Tagrix-80mg(Osimertinib)Tagrisso|Package Insert

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Buy Tagrix-80mg Tagrix-80mg-Oimertinib | Package Insert Description Tagrix-80mg-Osimertinib is a prescription medication used to treat adults with non-small cell lung cancer (NSCLC) that has abnormal epidermal growth factor receptor (EGFR) gene(s). EGFR is a protein that aids cell growth and division, but overactivity can cause cancer cells to grow and spread uncontrollably. Tagrix is a third-generation, irreversible EGFR-TKI with proven clinical activity in NSCLC, including against CNS metastases. It is used alone in patients whose cancer cells have specific mutations in a gene for EGFR. It is used to prevent lung cancer from returning after surgery, as a first treatment for metastatic lung cancer, or when previous treatment with an EGFR tyrosine kinase inhibitor (TKI) failed.

Indications Tagrix is a kinase inhibitor used to treat patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC) who have progressed on or after EGFR TKI therapy. It is approved under accelerated approval based on tumor response rate and duration of response, with continued approval contingent on verification and clinical benefit description in confirmatory trials. •

Adjuvant therapy is recommended for non-small cell lung cancer (NSCLC) patients who have undergone tumor resection, and whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R mutations.

For adult patients with metastatic NSCLC whose tumors have EGFR exon 19 deletions or exon 21 L858R mutations, first-line treatment is recommended.

In patients with metastatic EGFR T790M mutation-positive NSCLC, whose disease has progressed on or after EGFR tyrosine kinase inhibitor (TKI) therapy, treatment is recommended.

Mechanism of Action •

Tagrix (osimertinib) is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It works by irreversibly binding to and inhibiting the EGFR protein. EGFR is a protein that helps cells grow and divide. When EGFR is overactive, it can cause cancer cells to grow and spread uncontrollably.


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