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Computational and Systems Biology 2013/14

Featured textbooks


Systems biology and networks


Mathematical modeling


Statistics 9 Pattern recognition and machine learning


Knowledge management and data mining


Engineering mathematics


Neuroscience 15 Genetics and genomics


Biotechnology 18 Bioethics 18 Professional development


Also of interest


Related Journals

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Featured textbooks


Python Programming for Biologists

UNIX and Perl to the Rescue!

Bioinformatics and Beyond Tim Stevens and Wayne Boucher

A Field Guide for the Life Sciences (and Other Data-rich Pursuits) Keith Bradnam and Ian Korf

University of Cambridge

Presents core concepts in computational biology in an accessible, jargonfree manner and offers a complete foundation course in the Python language, with entry points for novices and experienced programmers alike. Material covers traditional bioinformatics and many topics beyond, with practical examples for Python versions 2 and 3. 2014 247 x 174 mm 500pp 978-0-521-89583-5 Hardback c. £75.00 978-0-521-72009-0 Paperback c. £29.99  Publication April 2014

University of California, Davis

Written in a fun, accessible style, this step-by-step guide teaches nonprogrammers the key aspects of Unix and Perl. Essential reading for those who want to work more effectively with large data sets. ‘UNIX and Perl to the Rescue! is a book I highly recommend for all those students, post-docs, and academics who are scared of programming but can benefit immensely from the power of Unix and scripting languages. It’s time to come out of your shell.’ Dr M. D. Sharma, Genetics Society News ‘… scientists Bradnam and Korf have come to the aid of laboratory or field researchers floundering helplessly under overwhelming gigabytes of unstructured raw data. With a characteristic charming and chipper cheerfulness, the book quickly guides the readers through finding/installing a UNIX system of any variety … Highly recommended.’ F. E. J. Linton, Choice

Contents: Part I. Introduction and Background; Part II. Installing Unix and Perl; Part III. Essential Unix; Part IV. Essential Perl; Part IV summary; Part V. Advanced Unix; Part V. Advanced Unix; Part VI. Advanced Perl; Part VII. Programming Topics. 2012 247 x 174 mm 428pp 5 b/w illus.   978-1-107-00068-1 Hardback £75.00 978-0-521-16982-0 Paperback £29.99 eBook available


Featured textbooks Genomics and Bioinformatics An Introduction to Programming Tools for Life Scientists Tore Samuelsson Göteborgs Universitet, Sweden

Designed for biologists without programming experience, this textbook provides a hands-on introduction to Unix and Perl tools for bioinformatics. Biological examples are combined with practical computational procedures, teaching students how to proceed from biological problem to bioinformatics solution. An accompanying website provides files, scripts and solutions to end-of-chapter exercises. ‘The book provides a lively and accessible introduction to current research in the life sciences, and it does so in a succinct way by grounding the explanations with simple algorithms expressed in Perl code. As such, the book can be very useful to a general science audience, particularly those with a computer science background, whether established researchers or undergraduate students. The writing is inspiring and engaging, and the inclusion of Perl code makes it easy for readers to apply the knowledge and observe the outcomes.’ Sara Kalvala, Computing Reviews

Contents: Preface; Acknowledgements; Design and conventions of this book; 1. Introduction – working with the molecules of life in the computer; 2. Gene technology – cutting DNA; 3. Gene technology – knocking genes down; 4. Gene technology – amplifying DNA; 5. Human disease – when DNA sequences are toxic; 6. Human disease – iron imbalance and the iron responsive element; 7. Human disease – cancer as a result of aberrant proteins; 8. Evolution – what makes us human?; 9. Evolution – resolving a criminal case; 10. Evolution – the sad case of the Tasmanian tiger; 11. A function to every gene – termites, metagenomics and learning about the function of a sequence; 12. A function to every gene – royal blood and order in the sequence universe; 13. A function to every gene – a slimy molecule; 14. Information resources – learning about flu viruses; 15. Finding genes – going ashore at CpG islands; 16. Finding genes – in the world of snurps; 17. Finding genes – hunting for the distant RNA relatives; 18. Personal genomes – the differences between you and me; 19. Personal genomes – what’s in my genome?; 20. Personal genomes – details of family genetics; Appendix I. Brief Unix reference; Appendix II. A selection of biological sequence analysis software; Appendix III. Short Perl reference; Appendix IV. Brief introduction to R; Index. 2012 246 x 189 mm 356pp 20 b/w illus.  70 colour illus.  23 tables  60 exercises   978-1-107-00856-4 Hardback £75.00 978-1-107-40124-2 Paperback £29.99 eBook available

Featured textbooks Bioinformatics for Biologists Edited by Pavel Pevzner University of California, San Diego

and Ron Shamir Tel-Aviv University

A team of renowned bioinformaticians take fresh approaches to lead biology students from first principles towards computational thinking. Intuitive explanations promote deep understanding, using little mathematical formalism. Covering essential bioinformatic topics in a concise textbook, the authors prepare students to meet the computational challenges of their life science careers. Contents: Part I. Genomes; Part II. Gene Transcription and Regulation; Part III. Evolution; Part IV. Phylogeny; Part V. Regulatory Networks. 2011 246 x 189 mm 392pp 37 b/w illus.  105 colour illus.  4 tables   978-1-107-01146-5 Hardback £91.00 978-1-107-64887-6 Paperback £40.00 eBook available


‘This volume contains a remarkable collection of individually-authored chapters cutting a wide swathe across the field as it is currently constituted. What is noteworthy, aside from the wide angle of the snapshot of today’s bioinformatics, something the editors promise to update in future editions, is the innovative and effective pedagogical emphasis apparent throughout … The editors set out to provide a resource for teaching bioinformatics to life science undergraduates, and this is reflected in the language, organization and mathematical restraint of the different chapters … It is highly suitable as a text or reference for bioinformatics courses at the graduate level, for biologists, medical students and computer scientists. Biological naïveté in thinking and writing plagues bioinformatics, and Pevzner and Shamir’s Bioinformatics for Biologists offers a wonderful therapy for that condition as well as an effective palliative for life science students’ math phobias.’ Professor David Sankoff, University of Ottawa

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Systems biology and networks Systems Biology: Simulation of Dynamic Network States Bernhard Ø. Palsson University of California, San Diego

Large omics data sets are difficult to interpret and use, but this practical book teaches how to build complex dynamical models of biochemical networks and simulate their responses. All examples in the text are available in MATLAB and MATHEMATICA® workbooks, allowing easy hands-on practice.

material that the research literature in quantitative systems biology should become accessible.’ Physics Today 2006 253 x 177 mm 336pp 978-0-521-85903-5 Hardback £51.00 eBook available

Networks in Cell Biology Edited by Mark Buchanan Guido Caldarelli

2011 247 x 174 mm 332pp 126 b/w illus.   978-1-107-00159-6 Hardback £48.00

Consiglio Nazionale delle Ricerche (CNR), Rome

eBook available

École Polytechnique Fédérale, Lausanne

Francesco Rao

Paolo De Los Rios University of Freiburg


Systems Biology Properties of Reconstructed Networks Bernhard Ø. Palsson University of California, San Diego

This textbook devoted to systems biology describes how to model networks, how to determine their properties, and how to relate these to phenotypic functions. The links between the mathematical ideas and biological processes are made clear, reflecting the irreversible trend of increasing mathematical content in biology education. To assist both teacher and student, an associated web site provides problem sets. ‘… [deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology … a welcome departure from the typical biology textbook … a very readable introduction to the subject … this is an exciting time for biology. The author exposes readers to enough


and Michele Vendruscolo University of Cambridge

With contributions from leaders in both network theory and modern cell biology, this is a key introductory text for graduate students and researchers in physics, biology and biochemistry. ‘This book describes the state of the art in understanding cellular networks through contributions by leaders in modern cell biology and network theory. It is clearly organized and exhibits an excellent balance between empirical studies and theory. The biological underpinnings are explained clearly and comprehensively, and the appendices give a great primer to the key mathematical concepts necessary for network analysis and modeling. This book will be of great use as a course textbook or for self-study.’ Reka Albert, Pennsylvania State University 2010 247 x 174 mm 280pp 73 b/w illus.   978-0-521-88273-6 Hardback £54.00 eBook available

Mathematical modeling Computational Mathematical Modeling: An Integrated Approach Across Scales Daniela Calvetti and Erkki Somersalo Case Western Reserve University, Ohio

A book that guides the reader through the mathematical modeling of real-world phenomena at both macroscopic and microscopic scales. The book, which emphasises computational skills, includes examples, self-study problems and MATLAB code to aid learning. Suitable for students in mathematics and the physical sciences at advanced undergraduate level and above. Monographs on Mathematical Modeling and Computation, 17

2013 247 x 174 mm 234pp 978-1-61197-247-4 Paperback £50.00

A Primer on Mathematical Models in Biology Lee Segel and Leah Edelstein-Keshet University of British Columbia, Vancouver

A book on mathematical modelling techniques for advanced undergraduate and graduate students in both biology and applied mathematics. Mathematical techniques are presented alongside powerful applications to biology, with emphasis on molecular events, excitable systems, and small protein and genetic circuits. 2013 247 x 174 mm 450pp 978-1-61197-249-8 Paperback £48.00

Mathematical Modelling in One Dimension An Introduction via Difference and Differential Equations Jacek Banasiak University of KwaZulu-Natal, South Africa

The universality of mathematical techniques is demonstrated through a wide variety of applications and a description of basic methods for their analysis. The author places equal importance on difference and differential equations, showing how they complement and intertwine in describing natural phenomena. AIMS Library of Mathematical Sciences

2013 216 x 138 mm 118pp 25 b/w illus.  35 exercises   978-1-107-65468-6 Paperback £15.99 eBook available

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Mathematical modeling Mathematical Models for Communicable Diseases Fred Brauer University of British Columbia, Vancouver

and Carlos Castillo-Chavez Arizona State University

A self-contained and comprehensive guide to the mathematical theory and modeling of disease transmission. Ideal for a graduate-level course on mathematical epidemiology and a useful resource for those involved with public health policy. CBMS-NSF Regional Conference Series in Applied Mathematics, 84

2013 247 x 174 mm 292pp 978-1-61197-241-2 Paperback £52.00

Genomic Clinical Trials and Predictive Medicine Richard M. Simon National Cancer Institute

Aimed at both clinical investigators and statisticians, this book covers the development and validation of prognostic and predictive biomarkers and their integration into clinical trials. Practical Guides to Biostatistics and Epidemiology

2013 247 x 174 mm 153pp 11 b/w illus.  3 tables   978-1-107-00880-9 Hardback £70.00 978-1-107-40135-8 Paperback £27.99 eBook available

Introduction to the Network Approximation Method for Materials Modeling Leonid Berlyand Pennsylvania State University

Alexander G. Kolpakov Università degli Studi di Cassino e del Lazio Meridionale

and Alexei Novikov Pennsylvania State University

This introductory text presents the state of the art in general framework approximation theory. Intended for graduate students in applied mathematics and related fields such as physics and engineering, it is also a useful overview of the topic for researchers in these areas. Encyclopedia of Mathematics and its Applications, 148

2012 234 x 156 mm 255pp 65 b/w illus.   978-1-107-02823-4 Hardback £50.00 eBook available

Statistics Advances in Statistical Bioinformatics Models and Integrative Inference for High-Throughput Data Edited by Kim-Anh Do University of Texas M.D. Anderson Cancer Center

Zhaohui S. Qin Emory University, Atlanta

and Marina Vannucci Rice University, Houston

Within the context of genomic medicine and with a strong focus on cancer research, this book describes the integration of high-throughput bioinformatics data from multiple platforms to inform our understanding of the functional consequences of genomic alterations. Written for statisticians interested in modeling and analysing high-throughput data. 2013 228 x 152 mm 520pp 120 b/w illus.  17 colour illus.  20 tables   978-1-107-02752-7 Hardback £80.00

Regression Analysis of Count Data

New in Paperback

Bayesian Inference for Gene Expression and Proteomics Edited by Kim-Anh Do MD Anderson Cancer Center

and Peter Müller Swiss Federal Institute of Technology, Zürich

Marina Vannucci Rice University, Houston

‘A text that has a systematic account of Bayesian analysis in computational biology has been needed for a long time. This book is a timely publication entirely devoted to cutting-edge Bayesian methods in genomics and proteomics research and many of its contributors are leading authorities in the field. It is thus an indispensable reference for researchers who are interested in applying Bayesian techniques in their own biological research.’ Ping Ma, Department of Statistics and Institute for Genomic Biology, University of Illinois, Urbana-Champaign

Second edition A. Colin Cameron

2012 228 x 152 mm 456pp 22 tables   978-1-107-63698-9 Paperback £30.00 Also available 978-0-521-86092-5 Hardback £60.00

University of California, Davis

eBook available

and Pravin Trivedi

Indiana University, Bloomington

Students in both social and natural sciences often seek regression methods to explain the frequency of events, such as visits to a doctor, auto accidents, or new patents awarded. The second edition provides the most comprehensive and up-to-date account of models and methods to interpret such data. Econometric Society Monographs, 53

2013 228 x 152 mm 540pp 17 b/w illus.  56 tables   978-1-107-01416-9 Hardback £80.00 978-1-107-66727-3 Paperback £35.00

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Statistics Introduction to Statistical Methods for Biosurveillance

Applied Longitudinal Data Analysis for Epidemiology

With an Emphasis on Syndromic Surveillance Ronald D. Fricker

A Practical Guide Second edition Jos W. R. Twisk

Naval Postgraduate School, Monterey, California

Discusses the design and evaluation of statistical methods for effective biosurveillance for readers with minimal statistical training. Weaving public health and statistics together, it presents basic and advanced methods with a focus on empirically demonstrating added value. 2013 234 x 156 mm 411pp 143 b/w illus.  3 maps  30 tables   978-0-521-19134-0 Hardback  £50.00 eBook available

Preventing and Treating Missing Data in Longitudinal Clinical Trials A Practical Guide Craig H. Mallinckrodt Eli Lilly and Company, Indianapolis, IN

Focusing on the prevention and treatment of missing data in longitudinal clinical trials, this book offers a practical guide to key principles and explains analytic methods for the non-statistician using limited statistical notation and jargon. Practical Guides to Biostatistics and Epidemiology

2013 247 x 174 mm 180pp 6 b/w illus.  32 tables   978-1-107-03138-8 Hardback £55.00 978-1-107-67915-3 Paperback £22.99 eBook available

Vrije Universiteit, Amsterdam

This second edition is revised and updated, including new chapters on the role of the time variable and new features of longitudinal data analysis. Review of the first edition: ‘… the book is a welcome reference manual or practical guide for practitioners of statistical methods in (but not limited to) epidemiological and clinical studies. The book’s main value is in its rather comprehensive presentation of a collection of longitudinal data analyses arising from different research questions. In this sense, the book is unique. Some practitioners of statistics may have struggled to learn longitudinal data analysis by reading manuals of software packages. This book is potentially of great benefit to them.’ Journal of the American Statistical Association 2013 247 x 174 mm 333pp 60 b/w illus.  212 tables   978-1-107-03003-9 Hardback £80.00 978-1-107-69992-2 Paperback £40.00 eBook available

Statistics New in Paperback

Large-Scale Inference

Statistical Principles for the Design of Experiments

Empirical Bayes Methods for Estimation, Testing, and Prediction Bradley Efron

Applications to Real Experiments R. Mead

Stanford University, California

S. G. Gilmour

‘In the last decade, Efron has played a leading role in laying down the foundations of large-scale inference, not only in bringing back and developing old ideas, but also linking them with more recent developments, including the theory of false discovery rates and Bayes methods. We are indebted to him for this timely, readable and highly informative monograph, a book he is uniquely qualified to write. It is a synthesis of many of Efron’s own contributions over the last decade with that of closely related material, together with some connecting theory, valuable comments, and challenges for the future. His avowed aim is ‘not to have the last word’ but to help us deal ‘with the burgeoning statistical problems of the 21st century’. He has succeeded admirably.’ Terry Speed, International Statistical Review


University of Reading University of Southampton

and A. Mead University of Warwick

This book focuses on the practical needs of applied statisticians and experimenters engaged in design, implementation and analysis in a variety of disciplines, including biological and physical sciences, engineering, medicine and agriculture. It contains numerous exercises and a wide range of examples drawn from real experiments. Cambridge Series in Statistical and Probabilistic Mathematics, 36

2012 253 x 177 mm 586pp 200 b/w illus.  400 tables  80 exercises   978-0-521-86214-1 Hardback £60.00 eBook available

Institute of Mathematical Statistics Monographs, 1

2012 228 x 152 mm 280pp 65 b/w illus.  10 colour illus.  105 exercises   978-1-107-61967-8 Paperback £24.99 eBook available

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Pattern recognition and machine learning Textbook

Machine Learning The Art and Science of Algorithms that Make Sense of Data Peter Flach University of Bristol

Machine Learning brings together all the state-of-the-art methods for making sense of data. With hundreds of worked examples and explanatory figures, the book explains the principles behind these methods in an intuitive yet precise manner and will appeal to novice and experienced readers alike. 2012 246 x 189 mm 409pp 120 colour illus.  15 tables   978-1-107-09639-4 Hardback £75.00 978-1-107-42222-3 Paperback £35.00 eBook available


Bayesian Reasoning and Machine Learning David Barber University College London

‘This book is an exciting addition to the literature on machine learning and graphical models. What makes it unique and interesting is that it provides a unified treatment of machine learning and related fields through graphical models, a framework of growing importance and popularity. Another feature of this book lies in its smooth transition from traditional artificial intelligence to modern machine learning. The book is well-written and truly pleasant to read. I believe that it will appeal to students and researchers with or without a solid mathematical background.’ Zheng-Hua Tan, Aalborg University, Denmark

Contents: Part I. Inference in Probabilistic Models; Part II. Learning in Probabilistic Models; Part III. Machine Learning; Part IV. Dynamical Models; Part V. Approximate Inference. 2012 246 x 189 mm 708pp 287 b/w illus.  1 table  260 exercises   978-0-521-51814-7 Hardback £45.00 eBook available


Knowledge management and data mining Fundamentals of Stream Processing

Data-Intensive Computing

Application Design, Systems, and Analytics Henrique C. M. Andrade

Architectures, Algorithms, and Applications Edited by Ian Gorton and Deborah K. Gracio

J. P. Morgan

Bugra Gedik Bilkent University, Ankara

and Deepak S. Turaga IBM Thomas J. Watson Research Center, New York

This book teaches fundamentals of the stream processing paradigm that addresses performance, scalability and usability challenges in extracting insights from massive amounts of live, streaming data. It presents core principles behind application design, system infrastructure and analytics, with real-world examples for a comprehensive understanding of the stream processing area. 2013 247 x 174 mm 624pp 191 b/w illus.  17 tables  10 exercises   978-1-107-01554-8 Hardback £65.00 Publication September 2013

Pacific Northwest National Laboratory

This reference for computing professionals and researchers describes the general principles of the emerging field of data-intensive computing, along with methods for designing, managing and analysing the big data sets of today. Applications in bioinformatics and cybersecurity illustrate these principles in practice. 2012 228 x 152 mm 297pp 82 b/w illus.  8 tables   978-0-521-19195-1 Hardback £45.00 eBook available

Mining of Massive Datasets Anand Rajaraman WalmartLabs

and Jeffrey David Ullman Stanford University, California

Written by two authorities in database and Web technologies, this is essential reading for students and practitioners. It teaches algorithms that have been used in practice to solve key problems in data mining and includes exercises suitable for students from the advanced undergraduate level and beyond. 2011 246 x 189 mm 326pp 90 b/w illus.  160 exercises   978-1-107-01535-7 Hardback £40.00 eBook available

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Engineering mathematics Variational Methods with Applications in Science and Engineering

Methods of Applied Mathematics for Engineers and Scientists

Kevin W. Cassel

Analytical and Numerical Approaches Tomas B. Co

Illinois Institute of Technology

There is a resurgence of applications for the calculus of variations, such as in solid mechanics and dynamics, numerical methods, numerical grid generation, modern physics, various optimization settings and fluid dynamics. This book reflects the connection between calculus of variations and the applications for which variational methods form the foundation. 2013 253 x 177 mm 416pp 112 b/w illus.  12 tables  108 exercises   978-1-107-02258-4 Hardback £65.00 Publication August 2013


Michigan Technological University

Co has written an engineering mathematics textbook, rich with examples, applications and exercises that use analytical approaches to solve smaller problems and numerical methods for complex problems. The book emphasises applying matrices with strong attention to matrix structure and computational issues. MATLAB® implementations and concepts are fully integrated. 2013 253 x 177 mm 650pp 176 b/w illus.  52 tables  298 exercises   978-1-107-00412-2 Hardback £75.00 Publication August 2013

Neuroscience Handbook of Neural Activity Measurement Edited by Romain Brette Ecole Normale Supérieure, Paris

and Alain Destexhe Centre National de la Recherche Scientifique (CNRS), Paris

Leading experts describe the various existing techniques for measuring neural activity (for example, intracellular recording and electroencephalograms). Readers will come to understand the physical principles underlying each technique and the precise relationship between the measured signals and neural activity. 2012 247 x 174 mm 489pp 95 b/w illus.  30 colour illus.   978-0-521-51622-8 Hardback £70.00 eBook available

New in Paperback

Information Processing by Neuronal Populations Edited by Christian Holscher University of Ulster

and Matthias Munk Max-Planck-Institut für biologische Kybernetik, Tübingen

This book addresses questions including how networks are formed and separated and associated with other networks. It strives to cover the range of single cell activity analysis to observation of network activity and to brain area activity and cognitive processes. 2012 244 x 170 mm 484pp 978-1-107-41129-6 Paperback £47.00 Also available 978-0-521-87303-1 Hardback £99.00


Principles of Computational Modelling in Neuroscience David Sterratt University of Edinburgh

Bruce Graham University of Stirling

Andrew Gillies Psymetrix Limited, Edinburgh

and David Willshaw University of Edinburgh

For neuroscientists at all levels and for people from the informational and physical sciences who want to develop computational models of the neuron and neural circuits. It presents the principles of computational neuroscience in a clear manner, and addresses practical issues that arise in modelling projects. ‘Here at last is a book that is aware of my problem, as an experimental neuroscientist, in understanding the maths … I expect it to be as mind expanding as my involvement with its authors was over the years. I only wish I had had the whole book sooner – then my students and post-docs would have been able to understand what I was trying to say and been able to derive the critical tests of the ideas that only the rigor of the mathematical formulation of them could have generated.’ Gordon W. Arbuthnott, Okinawa Institute of Science and Technology 2011 246 x 189 mm 402pp 178 b/w illus.  7 tables   978-0-521-87795-4 Hardback £43.00 eBook available

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Genetics and genomics Genetic Mapping in Experimental Populations J. W. Van Ooijen Kyazma B.V., Wageningen, The Netherlands

and J. Jansen Biometris, Wageningen University and Research Centre, The Netherlands

This concise introduction to genetic mapping in diploid species teaches the theory behind map construction, explains the computations involved at each stage, and provides exercises and problem-solving tips. 2013 247 x 174 mm 168pp 20 b/w illus.   978-1-107-01321-6 Hardback c. £75.00 978-1-107-60103-1 Paperback c. £29.99 Publication August 2013

students and researchers in a wide range of disciplines. Recommended for all academic libraries.’ Atsuo Ogura, RIKEN BioResource Center 2012 247 x 174 mm 548pp 100 b/w illus.  24 colour illus.  24 tables   978-1-107-00382-8 Hardback £125.00 eBook available

Basic Phylogenetic Combinatorics Andreas Dress Universität Bielefeld, Germany

Katharina T. Huber University of East Anglia

Jacobus Koolen Pohang University of Science and Technology, Republic of Korea

Vincent Moulton

Epigenomics From Chromatin Biology to Therapeutics Edited by Krishnarao Appasani GeneExpression Systems, Inc.

Leading experts from academia, the biotechnology and pharmaceutical industries introduce the emerging field of epigenomics, covering a wide range of topics and methods such as basic chromatin biology, imprinting at genome-wide level, and the role of epigenomics in disease biology and epidemiology. ‘This is an excellent work, highly readable and well documented by more than a hundred scientists from academia and industry. The extensive coverage of current theory, new technologies, and disease mechanisms, all associated with epigenomics, makes this book invaluable to


University of East Anglia

and Andreas Spillner Ernst-Moritz-Arndt-Universität Greifswald, Germany

The biosciences are generating new research directions in mathematical sciences. This book presents a new combinatorial theory that forms the basis for understanding structures such as phylogenetic trees and networks. Results are presented in full detail, so the reader can quickly reach the forefront of this fascinating new area. 2011 228 x 152 mm 276pp 55 b/w illus.   978-0-521-76832-0 Hardback £40.00 eBook available

Genetics and genomics Phylogenetic Networks Concepts, Algorithms and Applications Daniel H. Huson Regula Rupp Eberhard-Karls-Universität Tübingen, Germany

and Celine Scornavacca Centre National de la Recherche Scientifique (CNRS), Paris

‘Networks – rather than just trees – are fast becoming the essential tool for making sense of the complexities of evolution, and conflicting signal[s] in genomic data. Phylogenetic Networks provides a long-overdue exposition of networkbased methods, their possible uses, and details on practical software. A detailed and unified treatment of the many different types of networks is complemented by a crisp synopsis of the underlying theory. Numerous example[s] and illustrations make the text easy to follow. This book will further transform the way biologists use genomic data to study evolution. The Tübingen group has led the development of phylogenetic network algorithms, and this book delivers a clear exposition for biologists bewildered by a plethora of recent methods, as well as for bioinformaticians aiming to develop the field further. It is essential reading for any scientist or student seeking to understand how genomic data can be used to represent and study the intricate ‘web of life’.’



The Phylogenetic Handbook A Practical Approach to Phylogenetic Analysis and Hypothesis Testing Second edition Edited by Philippe Lemey University of Oxford

Marco Salemi University of California, Irvine

and Anne-Mieke Vandamme Katholieke Universiteit Leuven, Belgium

With a stronger focus on hypothesis testing, elaborate practical sections and recent versions of sequence analysis and software, this edition includes six new chapters. Topics on Bayesian inference, tree topology testing and the impact of recombination on phylogenies have been added as well as a detailed section on molecular adaptation. Contents: Part I. Introduction; Part II. Data Preparation; Part III. Phylogenetic Inference; Part IV. Testing Models and Trees; Part V. Molecular Adaptation; Part VI. Recombination; Part VII. Population Genetics; Part VIII. Additional Topics. 2009 247 x 174 mm 750pp 57 b/w illus.  18 tables   978-0-521-73071-6 Paperback £34.99 eBook available

Mike Steel, University of Canterbury 2010 247 x 174 mm 374pp 189 b/w illus.  80 exercises   978-0-521-75596-2 Hardback £36.99 eBook available

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Biotechnology Methodologies for Metabolomics Experimental Strategies and Techniques Edited by Norbert W. Lutz University Aix-Marseille, France

Jonathan V. Sweedler University of Illinois, Urbana-Champaign

and Ron A. Wevers University Medical Center Nijmegen, The Netherlands

Methodologies for Metabolomics provides comprehensive descriptions of

the newest strategies in metabolomic research. While a broad range of methodologies are presented, so too are applications including in vivo metabolomics in humans and animals as well as in vitro analysis of tissue samples, cultured cells and biofluids. 2013 253 x 177 mm 627pp 84 b/w illus.  83 colour illus.  37 tables   978-0-521-76590-9 Hardback £95.00 eBook available

Bioethics Human Identity and Identification Rebecca Gowland

Bioethics An Introduction Marianne Talbot

University of Durham

University of Oxford

and Tim Thompson

Written informally, including over 200 activities, detailed case studies and explanatory podcasts, this book encourages science students to formulate and evaluate their own arguments regarding biotechnical issues and their philosophical foundations.

Teesside University

Reflecting upon recent developments in research on the relationship between the body, environment and society, this book examines the role of the body in human identification and in the forging of identities. It integrates biological perspectives with current discourse in the social sciences, focusing particularly on bioarchaeology and forensic science. 2013 247 x 174 mm 233pp 9 b/w illus.  4 tables   978-0-521-88591-1 Hardback £75.00 978-0-521-71366-5 Paperback £29.99 eBook available

‘With its wonderful introduction into ethical theory and a multifaceted approach, it is an incomparable resource for the successful teaching of bioethics. The author’s eloquent writing … carefully examines practically every aspect of [this] exciting interdisciplinary [field] … a valuable reading of interest for both students and scholar[s], alike.’ Mirjana Brockett, Georgia Institute of Technology, Atlanta 2012 246 x 189 mm 478pp 54 b/w illus.  1 table  233 exercises   978-0-521-88833-2 Hardback £60.00 978-0-521-71459-4 Paperback £27.99 eBook available


Professional development Funding Your Career in Science From Research Idea to Personal Grant Ritsert C. Jansen Rijksuniversiteit Groningen, The Netherlands

How can you get the funding to establish or consolidate a career in science? This concise guide offers step-by-step advice, real-life stories and practical exercises to help you prepare effective career grant applications and optimise your funding opportunities. A must-read for students, postdocs, professors, and anyone else serious about science. 2013 228 x 152 mm 216pp 15 b/w illus.   978-1-107-04006-9 Hardback £45.00 978-1-107-62417-7 Paperback £16.99

Developing a Talent for Science Ritsert Jansen Rijksuniversiteit Groningen, The Netherlands

Successful Grant Proposals in Science, Technology and Medicine A Guide to Writing the Narrative Sandra Oster Oster-Edits, Oregon

and Paul Cordo Oregon Health Sciences University

A practical guide to writing effective narrative sections for scientific grant applications, this book is designed to enable you to successfully acquire research funding. The authors draw on real-life examples from more than twenty years of research, covering the content, organisation, phrasing, and scientific argumentation of narratives. 2013 228 x 152 mm 350pp 6 b/w illus.  20 tables   978-1-107-03809-7 Hardback c. £55.00 978-1-107-65930-8 Paperback c. £27.99 Publication November 2013

How can you make the most of your talent for science? This practical guide offers valuable recommendations, real-life stories and practical exercises to enable students, postdoctorates and professors to develop their skills and succeed in academia, industry or elsewhere. ‘This insightful book offers guidance toward an enhanced productive academic or professional scientific career … a must-read for any professional in the geophysical community and for those pursuing studies in this field.’ The Leading Edge 2011 228 x 152 mm 182pp 20 b/w illus. 978-0-521-19312-2 Hardback £48.00   978-0-521-14961-7 Paperback £16.99 eBook available

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Professional development Textbook

Scientific Method in Brief Hugh G. Gauch, Jr Cornell University, New York

Specifically designed to enhance perspective and encourage productivity, this is a guide to the key principles of scientific method including deductive and inductive logic, probability, parsimony and hypothesis testing. The examples and case studies span the physical, biological and social sciences and also highlight science’s interrelationship with the humanities. ‘A welcome, and well-informed, introduction for budding scientists to the general principles undergirding the rationality of science. The book draws powerful attention to the fact that future scientific advance itself depends on a proper understanding of scientific method.’ Roger Trigg, Emeritus Professor of Philosophy, University of Warwick, Senior Research Fellow, University of Oxford, and founding chair of the British Philosophical Association 2012 228 x 152 mm 303pp 37 b/w illus.  3 tables   978-1-107-66672-6 Paperback £24.99 eBook available


How to Prepare a Scientific Doctoral Dissertation Based on Research Articles Björn Gustavii Lund University Hospital

The article-based thesis is becoming increasingly common, especially in the ‘hard’ sciences such as biology, medicine and technology. Detailing examples of good versus bad practice, this easy-toread guide shows the PhD student how to prepare a thesis in this format. 2012 228 x 152 mm 101pp 40 b/w illus.  2 tables   978-1-107-66904-8 Paperback £14.99 eBook available

How to Write and Illustrate a Scientific Paper Second edition Bjorn Gustavii University Hospital, Lund, Sweden

This second edition has been broadened to include comprehensive advice on writing compilation theses for doctoral degrees, preparing case reports, advice on when to get a professional artist to redraw figures, what to include in figure legends and how to present them, and how to present statistical results. ‘This book ranks with the best in the field. It is brief, to the point and easy to follow … useful to the author and editor … and so recommended.’ Research Communications in Molecular Pathology and Pharmacology 2008 228 x 152 mm 178pp 978-0-521-70393-2 Paperback £16.99 eBook available

Also of interest Regenerative Pharmacology Edited by George Christ and Karl-Erik Andersson Wake Forest Institute for Regenerative Medicine

The first state-of-the-art book in the rapidly evolving field of regenerative medicine, focusing on the critical role that the pharmacological sciences will play in treatment of any disease or disorder characterised by a reduction or lack of viable cells or tissues. Invaluable for advanced students, postdoctoral fellows, and researchers. 2013 253 x 177 mm 356pp 28 b/w illus.  22 colour illus.  11 tables   978-0-521-89949-9 Hardback £80.00 eBook available

The Zebrafish Atlas of Macroscopic and Microscopic Anatomy Joseph A. Holden University of Utah

Lester L. Layfield University of Missouri School of Medicine

and Jennifer L. Matthews Zebrafish International Resource Center

Designed for researchers who require a fundamental understanding of zebrafish anatomy, this full-color atlas aids identification of gross and microscopic structures important to laboratory studies. The photomicrographs allow direct comparison with research slides and are focused exclusively on zebrafish, eliminating the need for exclusion of structures found in other fish.


Introduction to Cancer Biology Robin Hesketh University of Cambridge

‘Robin Hesketh has produced a remarkable introduction to cancer biology which covers all of the key areas of current knowledge and brings them up to date to current research concepts and developments remarkably. He writes in an accessible way that will be valuable for students fresh to biology but also produces a book that will be very useful to experienced biologists and physicians who want to have to hand a broad overview of this fast moving and diverse field … The structure of the book is clear and informative and encompasses critically important biological knowledge from the level of the cell to population studies in epidemiology … it is very challenging to introduce a book which is really useful both for new students and established practitioners. Robin Hesketh has succeeded remarkably well in doing so.’ Peter Selby, Director, Leeds Institute of Molecular Medicine 2012 246 x 189 mm 351pp 130 b/w illus.  38 colour illus.   978-1-107-01398-8 Hardback £75.00 978-1-107-60148-2 Paperback £29.99 eBook available

2013 276 x 219 mm 154pp 163 colour illus.   978-1-107-62134-3 Paperback £85.00 eBook available

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Also of interest Single-Molecule Cellular Biophysics Mark C. Leake University of Oxford

Covering state-of-the-art single molecule techniques and real-world applications in unravelling the inner workings of the cell, this textbook is indispensable for undergraduate students in the physical and life sciences. Every effort has been made to ensure the text can be easily understood by students from both disciplines. 2013 246 x 189 mm 284pp 43 b/w illus.  100 exercises   978-1-107-00583-9 Hardback £45.00 eBook available

Python for Software Design How to Think Like a Computer Scientist Allen B. Downey Olin College of Engineering, Massachusetts

A no-nonsense introduction to software design using the Python programming language. . ‘I liked this book. The presentation is neat and clean, I might even say cheerful. And I learned a lot, not least of all where higher level languages are going, and the terminology used to express that … I liked the pace of presentation. I liked the constant stirring of topics: a new feature, a hint on debugging, a few words on programming style, some thoughts on programming principles, then on to the next new feature. It really is a nice mix.’ Scientific Programming 2009 253 x 215 mm 270pp 25 b/w illus.  118 exercises   978-0-521-89811-9 Hardback £59.00 978-0-521-72596-5 Paperback £25.99 eBook available

Alan M. Turing Centenary Edition Sara Turing Afterword by John F. Turing Foreword by Lyn Irvine and Martin Davis ‘The book is full of brilliant treasures, anecdotal accounts of Turing’s eccentricity and genius, and insights into his science … This little book, with its kaleidoscopic picture of Alan Turing’s short life, goes some way towards decoding his mind, and his family.’ The Guardian 2012 228 x 152 mm 194pp 7 b/w illus.   978-1-107-02058-0 Hardback £17.99 eBook available

Membrane Structural Biology With Biochemical and Biophysical Foundations Second edition Mary Luckey San Francisco State University

Provides a strong foundation and comprehensive overview for students and an invaluable synthesis of cuttingedge research for working scientists. This edition is expanded to include and make accessible all the latest developments and topics, with 20+ new high resolution structures. Links between membrane research and human health are emphasised throughout. 2014 279 x 215 mm 400pp 184 b/w illus.  610 colour illus.  16 tables   978-1-107-03063-3 Hardback c. £40.00 Publication January 2014


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Computational and Systems Biology Catalogue 2013/14  

Latest Computational and Systems Biology books from Cambridge University Press

Computational and Systems Biology Catalogue 2013/14  

Latest Computational and Systems Biology books from Cambridge University Press