SINCE 1891
THE BROWN DAILY HERALD WEDNESDAY, FEBRUARY 7, 2018
VOLUME CLIII, ISSUE 11
WWW.BROWNDAILYHERALD.COM
Arts center met with controversy from Providence locals Elorza,
teachers union clash at City Hall
Vote on U.’s proposal delayed until March 20 following request for continuance By ERIC CHOI SENIOR STAFF WRITER
The Providence City Plan Commission has moved the vote on the University’s plan to build a performing arts center — which has sparked controversy over the possibility of demolishing or moving five historic buildings — to March 20, wrote Choyon Manjrekar, principal planner at Rhode Island’s department of planning and development, in an email to The Herald. The vote was first scheduled for Dec. 19 and then moved to Jan. 16, according to a press release from Rhode Island Public Radio. However, the University requested a continuance to move the decision again to March, Manjrekar wrote. At the December hearing, the public comments regarding the University’s proposal were “unanimous” in opposing the construction of the performing arts center, said Rachel Robinson, director of preservation at the Providence Preservation Society. After listening to the public
Teachers picket for pay raise outside as mayor delivers his State of the City address By SOPHIE CULPEPPER SENIOR STAFF WRITER
GUS REED / HERALD
After a December hearing featured concerns from various community members, the vote on the possible demolition of historic sites to build the performing arts center was postponed a second time. opinions, “it was clear that the proposal was not ready to be acted on at that meeting,” said Russell Carey ’91 MA’06, executive vice president for planning and policy at the University. “We requested a continuance, which … means that that matter stays on the agenda.”
It is unclear whether or not the initial plans will change before the hearing in March. “I’m not saying that they haven’t changed or they have changed,” Carey said. The possibility of demolishing or moving the historic buildings — all built in the 19th century — is one
source of opposition. One of the buildings at risk of being demolished is the Urban Environmental Lab, a proposition that has seen opposition from students and faculty, The Herald previously reported. The University could move the » See ARTS CENTER, page 2
Yesterday, in the Council Chambers of City Hall, Mayor Jorge Elorza was scheduled to begin his annual State of the City address at 6 p.m. But by 6 p.m., Elorza still had not made his entrance — and the staircases above and below the third-floor chambers were jam-packed. People chatted and chanted intermittently. Signs were written in English and Spanish, in bright colors and stark black marker. Some of the messages were personal: “Elorza … you were EDUCATED by PVD schools … Don’t throw us under the BUS!” » See ELORZA, page 2
U. researchers develop more complete model of sickle cell
COURTESY OF WIKIMEDIA COMMONS
The Titan supercomputer, located at the Oak Ridge National Laboratory in Tennessee, mapped fiber formation in sickle cells, enabling more detailed analysis of molecular interaction. Research conducted with this computer, the fourth-fastest of its kind in the world, has helped increase treatment options for sickle cell anemia.
Using supercomputer, University team simulates sickle cell formation, hopes to analyze possible treatments By CATE RYAN SENIOR STAFF WRITER
University researchers have developed computational methods using a supercomputer that enables them to dive deep inside sickle cells and analyze their molecular characteristics. By modeling the processes responsible for sickle cell formation, the team will be able to explore possible treatments for the disease. Sickle cell anemia is caused by a genetic mutation that makes normally concave, round red blood
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cells become stiff and misshapen, said George Karniadakis, professor of applied mathematics. Sickle cell was identified as the first molecular disease by Nobel laureate Linus Pauling in 1949. Pauling’s initial characterization was based on the behavior of hemoglobin, a molecule normally distributed evenly throughout the red blood cell. In an infected individual, the molecule “will self-assemble into a fiber, and this fiber will push the red blood cell into a sickle shape,” said Lu Lu GS, the study’s first author and
a member of Karniadakis’ research group. These fibers are rigid and behave similarly to the fibers in a plant stem, said Gregory Kato, professor of medicine and director of the Sickle Cell Center of Excellence at the University of Pittsburgh. While the cells affected by the disease are often thought of as sickleshaped, there are dozens of abnormal shapes they can also take, Karniadakis said. The presence of these abnormal red blood cells in the body catalyzes a sort of “crisis.” Unable to easily pass through thin vesicles and capillaries, hemoglobin cannot transfer oxygen everywhere it needs to go. The study, led by Karniadakis and
published in the Biophysical Journal, attempts to model hemoglobin fiber formation — a topic first discussed 30 to 50 years ago, but has since been relatively neglected in the field, Kato said. Today, the availability of supercomputer technologies makes the team’s study so unique. “They allowed for a new level of detail of molecular interaction … that has never been possible before,” Kato said. The study also stands out for its interdisciplinary approach to medicine, as it brought together mathematicians, engineers and physicians in an effort to learn more about sickle cell anemia, Karniadakis said.
Mapping the previously elusive process of fiber formation is an “expensive” computational problem, Karniadakis said. The problem’s complexity stems from the multi-scale approach necessary to consider both the microscopic and macroscopic implications of sickle cell anemia. The process “is more complex than most protein interactions. … There’s a lot of action going on,” Kato explained. Creating an accurate computational model required the use of the Titan supercomputer located at the Oak Ridge National Laboratory in Tennessee, as well as other facilities, and a smaller-scale system on campus » See SICKLE CELL, page 2
WEATHER
WEDNESDAY, FEBRUARY 7, 2018
NEWS Narragansett Bay Commission converts waste into energy to achieve sustainability
SCIENCE & RESEARCH University researchers study effects of longevity protein found in mitochondria of fruit flies
COMMENTARY Illick-Frank ’18, Sharpe ’18: U. has not been upfront about plans for performing arts center
COMMENTARY IBES committee member serves as chairman of group that supplies crowd-control weapons
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