Biochemical pharmacology - Lecture Notes, Study Materials and Important questions answers

Biochemical Pharmacology Lecture Notes, Study Materials and Important questions answers

Subject : Biochemical Pharmacology Introduction 1.

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What is `biochemical pharmacology'? - Answer (click here) What are drugs? - Answer (click here) Drugs and drug target molecules - Answer (click here) Drug molecules may or may not have physiological counterparts - Answer (click here)

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Synthetic drugs may exceed the corresponding physiological agonists in selectivity - Answer (click here) Metabolism of physiological mediators and of drugs - Answer (click here) Strategies of drug development - Answer (click here)

Pharmacokinetics 1.

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Pharmacokinetics - Answer (click here) Drug application and uptake - Pharmacokinetics - Answer (click here) Drug distribution - Pharmacokinetics - Answer (click here) Drug elimination: Kidneys - Answer (click here) Drug elimination: Metabolism - Answer (click here)

Pharmacodynamics 1.

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Pharmacodynamics - Answer (click here) Classes of drug receptors - Answer (click here) Mechanisms and kinetics of drug receptor interaction - Answer (click here) Drug dose-effect relationships in biochemical cascades - Answer (click here)

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Spare receptors - Answer (click here) Potency and efficacy - Answer (click here) Partial agonism and the two-state model of receptor activation - Answer (click here)

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Toxic and beneficial drug effects - Answer (click here)

The ionic basis of cell excitation 1.

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The ionic basis of cell excitation - Answer (click here) Ion gradients across the cell plasma membrane - Answer (click here) The physics of membrane potentials - Answer (click here) Voltage-gated cation channels and the action potential - Answer (click here) The origin of cell excitation - Answer (click here) Anion channels - Answer (click here)

Drugs that act on sodium and potassium channels 1.

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Drugs that act on sodium and potassium channels - Answer (click here) Local anesthetics - Answer (click here) Sodium channel blockers as antiarrhythmic agents - Answer (click here) Sodium channel blockers in epilepsia - Answer (click here) Potassium channel blockers - Answer (click here) Potassium channel openers - Answer (click here)

Some aspects of calcium pharmacology 1.

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Some aspects of calcium pharmacology - Answer (click here) Calcium in muscle cell function - Answer (click here) Calcium channel blockers - Answer (click here) Digitalis (foxglove) glycosides - Answer (click here) Calcium-dependent signaling by adrenergic receptors - Answer (click here)

Some aspects of neurophysiology relevant to pharmacology 1.

Some aspects of neurophysiology relevant to pharmacology - Answer (click here)

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Structure and function of synapses - Answer (click here) Mechanisms of drug action on synapses - Answer (click here) Pharmacologically important neurotransmitters and their receptors Answer (click here)

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Neurotransmitter receptors - Answer (click here) Overview of the autonomic nervous system - Answer (click here)

G protein coupled receptors 1.

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G protein-coupled receptors - Answer (click here) Structure and function of G protein-coupled receptors - Answer (click here) The complexity of G protein signalling - Answer (click here)

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Agonist-specific coupling - Answer (click here) GPCR oligomerization - Answer (click here) 'Allosteric' GPCR agonists and antagonists - Answer (click here)

Pharmacology of cholinergic synapses 1.

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Pharmacology of cholinergic synapses - Answer (click here) Structure and function of the nicotinic acetylcholine receptor - Answer (click here)

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Cholinergic agonists - Answer (click here) Cholinergic antagonists - Answer (click here) Cholinesterase antagonists - Answer (click here)

Pharmacology of catecholamines and of serotonin 1.

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Pharmacology of catecholamines and of serotonin - Answer (click here) Biosynthesis and degradation of catecholamines - Answer (click here) Pharmacokinetic aspects - Answer (click here) Drug targets in catecholaminergic synapses - Answer (click here) Adrenergic receptor agonists and antagonists - Answer (click here) Inhibitors of presynaptic transmitter reuptake - Answer (click here) Inhibition of vesicular storage - Answer (click here) Indirect sympathomimetics - Answer (click here) L-DOPA and carbidopa in the therapy of Parkinson's disease - Answer (click here)

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False transmitters - Answer (click here) Cytotoxic catecholamine analogs - Answer (click here) Monoamine oxidase inhibitors - Answer (click here)

Pharmacology of nitric oxide NO 1.

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Pharmacology of nitric oxide (NO) - Answer (click here) Vascular effects of nitric oxide - Answer (click here) Nitric oxide synthase and its isoforms - Answer (click here) Biochemical mechanisms of NO signaling - Answer (click here) Role of NO in macrophages - Answer (click here) NO releasing drugs - Answer (click here) NOS inhibitors - Answer (click here)

Pharmacology of Eicosanoids 1.

Pharmacology of Eicosanoids - Answer (click here)

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Biosynthesis of eicosanoids - Answer (click here) Cyclooxygenase inhibitors - Answer (click here) Lipoxygenases and related drugs - Answer (click here)

Some principles of cancer pharmacotherapy 1.

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Some principles of cancer pharmacotherapy - Answer (click here) Cell type-specific antitumor drugs - Answer (click here) The cell cycle - Answer (click here) Alkylating agents - Answer (click here) Antibiotics - Answer (click here) Antimetabolites - Answer (click here) Inhibitors of mitosis - Answer (click here) Monoclonal antibodies in tumour therapy - Answer (click here)