Chiral Pool Synthesis

Chiral Pool Synthesis BOC Sciences has a first-class R & D team and many years of rich experience in chiral synthesis to provide you with comprehensive synthesis services. BOC Sciences is highly focused on customized synthetic service business, which can efficiently carry out pilot scale-up, technical verification, and commercial production, ensure product quality stability and safety, saving time and cost for customers.

The mirror image of a chiral molecule can be termed as enantiomer. As exhibited as below, a pair of enantiomers is structurally symmetrical but not completely coincident in chemistry.

Chiral synthesis, is also called enantioselective synthesis, plays an essential role in the discovery of innovative drugs and materials and has been widely used in the development of pharmaceutical products and other biologically active substances. For example, axially chiral biaryls is one of the most important activity structures of many drug molecules.

It can be synthesized by metal-mediated cross coupling metal-mediated cross coupling, de novo construction of an aromatic ring, point-to-axial chirality transfer or an atropselective transformation of an existing biaryl.

Methods of Chiral Synthesis

Biocatalysis Biocatalysis is a method that performs chemical transformations using biological compounds from isolated enzymes to living cells. Biocatalysts are commonly used in industry for their advantages. Yeast is a typical biocatalyst for the chiral reduction of ketones.

Chiral pool synthesis Enantioselective catalysis Chiral auxiliaries Organocatalysis Our Services

Chiral Auxiliaries The Chiral auxiliary is a compound or unit that is temporarily added to organic synthesis in order to control the synthesis of stereochemistry.

By adding the chiral auxiliary, the prochiral substrate can be transformed into a chiral product. Moreover, through an auxiliary recycle, the auxiliary can be typically recovered for future use.

Chiral Building Blocks Chiral Catalysts Chiral Ligands Chiral Resolution Our Project Management

At BOC Sciences, we can provide various types of methods including biocatalysis, chiral pool synthesis, enantioselective catalysis, chiral auxiliaries, and organocatalysis. We also use multiple techniques (NMR, LCMS, GCMS, X-ray) to analyze compounds after the chiral synthesis completed. Our experts will work with you to optimize the synthetic route and approaches. Additionally, according to your needs and the properties of chemical substances, a wide range of custom services are available in our laboratory.

References 1. Jolliffe, J. D., Armstrong, R. J., & Smith, M. D. (2017). Catalytic enantioselective synthesis of atropisomeric biaryls by a cation-directed Oalkylation. Nature Chemistry, 9(6), 558.

2. Silverman, R. B., & Xue, F. (2015). U.S. Patent No. 9,212,161.

Washington, DC: U.S. Patent and Trademark Office.