BU BME 2022 Annual Report

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Boston University College of Engineering

Department of Biomedical Engineering

BIOMEDICAL ENGINEERING

ABOVE: The Wong lab is a design-driven lab where we apply synthetic biology to engineer desired properties in mammalian cells, with application in understanding cellular design principles and developing cellular therapy.

Highlights transformative Technologies

Since its inception, Boston University’s biomedical engineering department has maintained a holistic and interdisciplinary approach to new research. Its commitment to working at multiple levels—from the scale of molecules to entire organs—has led to extraordinary scientific innovations and technological advancements in tissue engineering, synthetic biology, neural engineering, and other groundbreaking areas.

Part of this success is due to the dynamic environment in which the department operates: faculty collaborate freely across multiple fields, and are encouraged to work on thorny problems that other researchers might shy away from tackling.

“I would say audaciousness is what defines our department,” says Chair John White. “It’s not just about making incremental progress. We choose faculty that want to work on really big, difficult problems that can shape healthcare 10-20 years in the future. They’re scientific risk takers, and we provide an environment where it’s safe to take those risks.”

This core philosophy is highlighted by current work taking place within the department. Scientists and engineers under its auspices are conducting research in wide-ranging yet deeply impactful areas: together, they’re designing new synthetic RNA that can detect viruses; building ways to diagnose neurological diseases with more specificity than ever before; and growing living heart tissue patches that could eventually save the lives of thousands of patients worldwide.

In all these cases, researchers are mounting a tireless effort to improve healthcare, making it safer, cheaper, more effective, and broadly deployable. “As biomedical engineers, it’s our calling in the world to improve human health,” says White. “That’s what drives every single person here.”

At right, discover the work of three visionary researchers within the department: Professor of Biomedical Engineering Chris Chen; Associate Professor Anna Devor; and Assistant Professor Alex Green—and learn how their audacious ideas might change the face of medicine.

Visionary BME Faculty shape the future of healthcare

Lab-Made Heart Tissue

The heart is arguably the hardest-working tissue in in the human body: it’s one of the first organs to form in the womb, and must keep ticking, without end, for the rest of our lives. Astoundingly, though, the cells within it can’t easily divide and reproduce. If damage occurs to any of them, that’s it—the injured tissue won’t be able to repair itself, leaving the remaining parts of the organ about to limp along as best as they can.

Professor Chris Chen wants to improve that outcome. He’s working to create new heart tissue in the lab, and is using a patient’s own skin or blood cells as a starting point. Through a complex biological process, Chen can reprogram those cells, turning them into pluripotent stem cells—a sort of universal cell that can become almost any kind of tissue in the body. From there, he anchors them onto a specialized substrate that cues them to become cardiomyocytes, the pulsating muscle cells that keep the heart beating. Because this newly-formed heart tissue originated from parts of the patient’s own body, there’s almost no chance that it would trigger an immune response, says Chen.

At the moment, Chen and his team are still develoing and testing the concept in the lab. While these heart patches aren’t yet ready to be used in humans, he notes, they may be incredibly valuable tools for developing new drug treatments. “The human heart can react very differently to a drug than animal heart cells,” he says.

“It’s very possible to miss a cardiotoxicity in the course of testing potential drugs. If you do, you’ve wasted a huge amount of resources developing a compound that turns out to be toxic to human cardiac tissue.” Lab-made human heart tissue, however, might help researchers catch those issues early, making drug development faster and more accurate—advances that could offer new hope for patients with serious heart disease.

The human heart can react very differently to a drug than animal heart cells. It’s very possible to miss a cardiotoxicity in the course of testing potential drugs.”

- Professor Chris Chen

Anna Devor and the USArhythms team: Diagnosing Cognitive Health with fMRI

Early diagnosis of cognitive disorders, including Alzheimer’s disease and dementia, is a challenge. Often, these disorders involve dysfunction of specific neuronal circuits controlling our alertness, arousal, and cognitive performance, such as our ability to focus or pay attention. While currently there’s no way to directly examine if any one specific neuronal circuit has been compromised, having such a tool would impact clinicians and basic scientists alike. For clinicians, it would allow stratifying patients based on the underlying neurobiological mechanisms. For basic scientists, knowing the mechanism of disease guides the development of targeted drugs and other interventions.

A multidisciplinary team of researchers led by Associate Professor Anna Devor is working on ways to squeeze more detailed information out of an existing noninvasive brain imaging technique called fMRI. fMRI shows changes in cerebral blood flow, which are driven by neuronal activity causing dilation and constriction of brain arteries.

The team USArhythms incudes researchers across two continents and four academic institutions. By performing parallel experiments in humans and mice and combining experimentation with computational modeling, they are identifying unique fMRI patterns that correspond to activity in specific brain-wide neuronal circuits. This is a first step towards a definitive way of telling whether those circuits are working correctly.

“If you may’ve broken a bone, your doctor doesn’t rely on your verbal report. They take an X-ray to see if there’s a fracture. At the moment, that kind of specific imaging capability is missing for cognitive disorders,” she says. “In the case of Alzheimer’s, by the time memory loss sets in, your brain has already experienced massive damage. As with any other disease, if we can find a way to catch it early, more options for treatment may be available.”

As with any other disease, if we can find a way to catch it early, more options for treatment may be available.”
- Associate Professor Anna Devor

Alex Green: Detecting Viruses with RNA “Sensors”

With a global Covid-19 pandemic still circulating and a Monkeypox outbreak gathering steam, detecting viruses quickly and efficiently is proving to be critical for public health. Right now, the only way to do that definitively is by testing whether viral DNA is present in a sample, a process that can take up to a day to complete using expensive equipment in centralized laboratories.

New paper-based tests that are being developed at BU could offer a cheaper and more nimble solution. The tests, which were created by Assistant Professor Alex Green, rely on folded molecules of RNA that they make in the lab. Green and his team the freeze-dry the DNA template to make the RNA along with other key enzymes needed to read genetic code, then apply the molecules onto a paper strip. When a sample of saliva or other liquid is applied, the mixture activates and goes to work searching for a virus.

“The RNA we make is basically acting as a molecular sensor,” says Green. “If it finds the right sequence from a virus and binds to it, the RNA molecule unfurls and creates an enzyme.” That enzyme in turn breaks down chemicals in a yellow dot on the test strip, changing it into a bright purple that indicates a positive result.

Unlike existing tests, these paper versions cost just a few dollars, and can be customized to search for any gene within a few days. If kept dry, they could last for months at a time, which would help emergency responders respond to future outbreaks before they become widespread.

The RNA we make is basically acting as a molecular sensor.”
- Assistant Professor Alex Green

BME Department 2021-2022

Faculty

In fiscal year 2022 the BME Department faculty search added four new faculty that will start in the next year. Assistant Professors Michelle Teplensky and Adriana Tomic will start September 1, 2022 and Assistant Professors Brian DePasquale and Liangliang Hao will start January 1, 2023. At the end of FY 2022, the BME faculty numbered 40, making the department one of the largest in the country in terms of primary faculty.

Graduate Program

The BME PhD Program awarded 24 degrees in AY21-22, bringing our total PhD degrees awarded to 396 since the program began in 1991. 41 MS degrees were awarded, as well as 19 MEng degrees. Our graduate programs enrolled 255 students (169 PhD students; 4 MD/PhD; 42 MS; 26 MEng).

Graduate student recruitment: In the fall 2022 we matriculated 99 new graduate students (40 PhD, 24 MS, 20 MEng and 15 LEAP). Our applicant pool continues to be competitive with other top tier Biomedical Engineering Programs. In the 2021 – 2022 recruiting season, we received 1,087 applications (PhD, MS and MEng).

Undergraduate Program

The BME Undergraduate Program awarded 126 Bachelor of Science degrees and enrolled 588 students in AY 21-22.

Research

In FY 2022 the BME faculty was awarded $51,532,933 in extramural funds available for expenditure during the year. They expended $40,122,863. This translates to about $1.56M per research active faculty member in new funding and $1.21M per research active faculty member in expenditures. The faculty submitted 135 research proposals for $169M.

Our faculty is comprised of world renowned scientists and engineers who work across every scale of biology and in a wide spectrum of bioengineering subspecialties. Their research is driven by advancing fundamental understanding of biology and physiology in health and disease and then translating these principles to new technologies that impact the human condition and the practice of medicine. The research laboratories of the research active faculty members are listed on our web site (http://www.bu.edu/bme/research/labs/) and they also participate in 8 interdisciplinary research centers that are directed by BME faculty: Bioengineering Technology and Entrepreneurship Center (BTEC), Biological Design Center (BDC), Biomolecular Engineering Research Center (BMERC), Center on Forced Displacement (CDF), NSF Engineering Research Center in Cellular Metamaterials (CELL-MET), Nanotechnology Innovation Center (BUnano), Neurophotonics Center (NPC), and Precision Diagnostics Center (PDC).

“ As biomedical engineers, it’s our calling in the world to improve human health. That’s what drives every single person here.“
- John A. White, BME Department Chair

40 Primary Faculty 169 PhD Students

588 Undergraduates

89 Courses Taught

$52 MILLION Research Funding

ADMINISTRATION

CHAIR

Dr. John A. White

VICE CHAIR

Dr. Muhammad Zaman

ASSOCIATE CHAIR FOR GRADUATE PROGRAM

Dr. James Galagan

ASSOCIATE CHAIR FOR UNDERGRADUATE PROGRAM

Dr. Irving Bigio

DIRECTOR OF PROFESSIONAL MASTERS PROGRAMS

Dr. Mario Cabodi

DIRECTOR OF PHD PROGRAM ADMISSIONS

Dr. Darren Roblyer

DIRECTOR FOR MASTERS PROGRAM ADMISSIONS

Dr. Kamal Sen

DIRECTOR

Matthew Barber

ASSOCIATE DIRECTOR

Christen Bailey

ASSISTANT DIRECTOR, FINANCE & ADMINISTRATION

Crystal Kelly

BME DEPARTMENT STAFF

ADMINISTRATIVE

Stefanie Salguero, Administrative Assistant to the Chair

Stephanie Johnson, Senior Program Coordinator

Lyn Markey, Design and Communications

Dr. Joshua Finkelstein, Executive Director, BDC

Lena Landaverde, Assistant Director PDC

ACADEMIC

Inna Gerzon, Professional Masters Programs Administrator

John Benducci, Undergraduate Program Administrator

FINANCIAL

Kyle Best, Financial Administrator

Katie Eno, Financial Manager

Irene Orzechowski, Financial Manager

Laura Prusaitis, Financial Manager

Tara Sorrentino, Financial Manager

Associate Professor Ahmad “Mo” Khalil was recognized with 3 major awards: the Schmidt Science Polymaths Award, the Future Fund Grant, and the WM Keck Foundation Medical Research Award. Based on his lab’s expertise in synthetic biology and solid track record of collaboration, the awards will empower Khalil to expand his lab’s science into new therapeutic innovations, uncovering the design principles of natural cellular circuits, and how they carry out specific biological functions.

Assistant Professor Laura Lewis was included in special issue of Science devoted to the essential physiological process of sleep. Her article discusses how sleep maintains the health of the brain through interconnected systems of neuronal activity and fluid flow. Lewis and her lab team focus on a common brain imaging technique— functional magnetic resonance imaging (fMRI)—to innovate new technologies for monitoring brain activity during sleep.

A new $2.3 million outreach program, led by BU Professor Douglas Densmore and funded by the Department of Defense, will introduce hundreds of underserved high school students to STEM careers and the emerging field of synthetic biology.

Assistant Prof. Hadi Nia was awarded a Beckman Young Investigator Award. The Beckman Foundation’s mission is to support the most promising young faculty members in the early stages of their academic careers in the chemical and life sciences, particularly to foster the invention of new research methods, instruments, and materials.

Two recent BME grads, Meghan Griffin and Leen Arnaout, garnered a top award in the 2021 Biomedical Engineers Society (BMES) Design Competition. Their novel device, a bracelet that helps regulate breathing in premature infants, would treat Apnea of Prematurity, which affects more than 85% of these infants. The duo are working with BU’s Office of Technology Development to eventually bring the device to market.

After developing a breakthrough method of regenerating liver tissue, Prof. Chris Chen and colleagues have launched a startup, Satellite Bio. The company says its novel technology, which it calls “tissue therapeutics,” would allow scientists to program cells and aggregate them “into novel, implantable therapies, called ‘satellites,’ which can be introduced to patients to repair, restore, or even replace dysfunctional or diseased tissue or organs”.

Assistant Professor Alexander Green has received a 2021 Scialog Collaborative Innovation Award from the Research Corporation for Scientific Advancement to develop a new type of sensor capable of detecting heretofore hidden signals within a cell, with potential applications both diagnostic and therapeutic.signals within a cell, with potential applications both diagnostic and therapeutic.

BME Profs. Mark Grinstaff, Wilson Wong and MGH’s Yolonda Colson were selected by the National Cancer Institute and NBIB for an award supporting trans-disciplinary teams employing collaborative approaches to engineer biology for cancer applications. The team will study precise tumor targeting with logic CAR circuits.

BU BME Seminars 2021-22

Joshua Glaser, PhD Columbia University

Interpretable Machine Learning for Systems Neuroscience

Longzhi Tan, PhD Stanford University

Probing the single-cell 3D genome architectural basis of neurodevelopment and aging in vivo

Arina Korneva, PhD Johns Hopkins University

Biomechanics of the Optic Nerve Head in Glaucoma

Liangliang Hao, PhD MIT

Visualizing the unseen: Enabling precision oncology through microenvironmenttriggered diagnostics and therapeutics

Changyang Linghu, PhD MIT

Multiplexed and Scalable Readout of Cellular Activities Enabled by Synthetic Protein Self-assemblies

Kayhan Batmanghelich, PhD University of Pittsburgh

Helping ML Models with Medical Insights for Learning, Inference, and Model Explanation

Michelle Teplensky, PhD Northwestern University Enhancing Immunity through Rational Design of Vaccine Structure

Jesse Marshall, PhD Harvard University Measuring the body to understand the mind

Hayden Metsky, PhD Broad Institute Designing genomics-based tools that surveil and combat pathogens at scale

Santiago Correa, PhD Stanford University Self-Assembling Nanotechnologies

Ritchie Chen, PhD Stanford University Biohybrid Tools to Study Brain and Body Circuits

Shiva Farashahi, PhD Flatiron Istitute Exploring Neural Mechanisms of Adaptive Behavior

Holly Wiberg, PhD MIT

Data-Driven Healthcare via Constraint Learning and Analytics

Brian DePasquale, PhD Princeton Neuroscience Institute An integrated statistical and mechanistic approach to modeling dynamic neural computation

Mariano Gabitto, PhD Allen Institute for Brain Science Learning Structure in Single-cell Chromatin Data During Cortical Development

Amirali Aghazadeh, PhD University of California, Berkeley Trusted AI for Molecular Inference: the Role of Sparsity

Xiaojun Cheng, PhD Boston University

Light Scattering in Dynamic Brain Tissue: Theoretical Exploration of Methods to Improve the Performance of Optical Imaging Techniques

BME Distinguished Seminars

Kathleen E. Cullen, PhD Johns Hopkins University

Predictive Coding of Natural Self-Motion: Implications for Perception & Action

Maribel Vazquez PhD Rutgers University

Microfluidic Modeling of the Regenerative Behaviors of Retinal Stem Cells

James A. Van Deventer, PhD Tufts University

Genetic Code Manipulation in Yeast

Ashutosh Agarwal, PhD University of Miami Human Organoids on a Chip

BU BME Faculty Publications

(sampling)

Ji-Xin Cheng, John White et al - LIGHT: SCIENCE AND APPLICATIONS

Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter

Hadi Nia et al - NATURE BIOMEDICAL ENGINEERING

Solid stress impairs lymphocyte infiltration into lymph-node metastases

Laura Lewis - SCIENCE

The interconnected causes and consequences of sleep in the brain

Laura Lewis - PROGRESS IN NEUROBIOLOGY

How pushing the spatiotemporal resolution of fMRI can advance neuroscience

Anna Devor - CURRENT OPINION IN BIOMEDICAL ENGINEERING

A suite of neurophotonic tools to underpin the contribution of internal brain states in fMRI

Anderson Chen et al - NATURE METHODS

An adaptive optics module for deep tissue multiphoton imaging in vivo

Muhammad Zaman - PROJECT SYNDICATE

Learning from COVID to Fight Drug-Resistant Disease

Oded Ghitza - eNEURO

Acoustically Driven Cortical Delta Oscillations Underpin Prosodic Chunking

Tim O’Shea et al. - NATURE

Divergent transcriptional regulation of astrocyte reactivity across disorders

Ahmad (Mo) Khalil - SCIENCE

One cell, many fates A synthetic gene circuit enables programming of many stable states in mammalian cells

Mary Dunlop - SCIENCE

Anticipating Antibiotic  Resistance

Alex Green - NATURE BIOMEDICAL ENGINEERING

Multi-arm RNA junctions encoding molecular logic unconstrained by input sequence for versatile cell-free diagnostics

Mark Grinstaff et al. - NATURE - ONCOGENE

H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth

Ahmad (Mo) Khalil, et al. - CELL

Modular design of synthetic receptors for programmed gene regulation in cell therapies

Chris Chen et al. - SCIENCES ADVANCES

Engineering a living cardiac pump on a chip using high-precision fabrication

Joe Tien - CELLULAR AND MOLECULAR BIOENGINEERING

Adipose stroma accelerates the invasion and escape of human breast cancer cells from an engineered microtumor.

Primary Faculty

IRVING J. BIGIO

Professor, Biomedical Engineering; Electrical and Computer Engineering; Physics; Medicine PhD, Physics, University of Michigan

Medical applications of optics, lasers and spectroscopy; biomedical optics and biophotonics; biomolecular dynamics; applied spectroscopy, especially to biomedical problems; nonlinear optics; quantum electronics and laser physics.

DAVID BOAS

Professor, Biomedical Engineering; Electrical and Computer Engineering; Director, Neurophotonics Center PhD, Physics, University of Pennsylvania

Neurophotonics; biomedical optics; functional near infrared spectroscopy; microscopy methods; oxygen delivery and consumption; neuro-vascular coupling; physiological modeling.

CHRISTOPHER S. CHEN

Professor, Biomedical Engineering; Director, Biological Design Center MD, Harvard University; PhD, Medical Engineering, MIT

My laboratory seeks to understand how cells interact with their environment, and to use this knowledge to control cell function. In particular, we are studying the cooperation between adhesive, mechanical and biochemical signaling in the regulation of angiogenesis and stem cell biology.

JI-XIN CHENG

Professor, Biomedical Engineering; Electrical and Computer Engineering; Chemistry; Physics; Moustakas Chair Professor in Photonics and Optoelectronics

PhD, Chemical Physics, University of Science and Technology of China

Molecular spectroscopic imaging technologies; label-free microscopy; medical photonics; neurophotonics; cancer metabolism; photonics for infectious diseases.

BRIANNE CONNIZZO

Assistant Professor, Biomedical Engineering

PhD, Bioengineering, University of Pennsylvania

Aging, orthopaedic and soft tissues, mechanobiology, multiscale biomechanics, extracellular matrix assembly and remodeling.

EDWARD DAMIANO

Professor, Biomedical Engineering PhD, Applied Mechanics, RPI

Integrated cellular and extracellular biomechanics; biofluid dynamics; microhemofluidics; microcirculation; vestibular biomechanics; non-Newtonian rheology; closed-loop bloodglucose regulation.

CHARLES DELISI

Metcalf Professor of Science and Engineering; Dean Emeritus, College of Engineering PhD, Physics, New York University

Developing and applying computational/mathematical methods, and high throughput experimental methods for inferring the structure and function of protein networks.

ALLISON M. DENNIS

Assistant Professor, Biomedical Engineering

PhD, Bioengineering, Georgia Institute of Technology

Nanobiotechnology; fluorescent biosensing; fluorescence resonance energy transfer (FRET); quantum dot chemistry; fluorescence microscopy; single molecule sensing/imaging.

ANNA DEVOR

Associate Professor, Biomedical Engineering

PhD, Hebrew University of Jerusalem, Israel

Cellular and systems-level neuroscience, microscopy, physiological underpinning of noninvasive imaging.

MARY DUNLOP

Associate Professor, Biomedical Engineering

PhD, Mechanical Engineering, California Institute of Technology

Understanding how microorganisms use feedback to respond to changes in their environment, studying naturally occurring examples of feedback to understand their implications for survival in changing conditions, and engineering novel, synthetic feedback control systems.

MICHAEL ECONOMO

Assistant Professor, Biomedical Engineering

PhD, Biomedical Engineering, Boston University

Systems neuroscience, motor control, long-range neural circuits, computational neuroscience, neurotechnology.

SOLOMON EISENBERG

Professor, Biomedical Engineering; Electrical and Computer Engineering; Senior Associate Dean for Academic Programs, College of Engineering

ScD, Electrical Engineering, MIT

Electrically mediated phenomena in tissues and biopolymers; cartilage biomechanics; computational modeling of electric field distributions in the human thorax and heart during defibrillation; transcranial magnetic stimulation.

JAMES GALAGAN

Professor, Biomedical Engineering; Microbiology, BUSM

PhD, Computational Neuroscience, MIT

Biosensor Development, Computational Biology, Systems Biology, Genomics.

ALEXANDER GREEN

Assistant Professor, Biomedical Engineering

PhD, Materials Science and Engineering, Northwestern University

Synthetic biology, nucleic acid nanotechnology, low-cost diagnostics, nanomaterials.

MARK GRINSTAFF

Professor, Biomedical Engineering; Chemistry; Director, Nanotechnology Innovation Center

PhD, Chemistry, University of Illinois Urbana-Champaign

Biomaterials; tissue engineering; drug delivery; macromolecular chemistry and engineering, self-assembly; nanodevices.

XUE HAN

Professor, Biomedical Engineering

PhD, Physiology, University of Wisconsin-Madison

Neurotechnology; optical neural modulation; optogenetics; neural prosthetics; neural network dynamics; brain rhythms; neurological and psychiatric diseases; cognition.

Primary Faculty Cont

DIANE JOSEPH-MCCARTHY

Professor of the Practice, Biomedical Engineering;

Executive Director, Bioengineering Technology & Entrepreneurship Center

PhD, Physical Chemistry, MIT

Chemical Biology, Biophysics, Computational Science, Drug Discovery & Development.

SIMON KASIF

Professor, Biomedical Engineering PhD, Computer Science, University of Maryland

Genomic systems biology, P4 medicine, wellness and disease prevention, medical bioinformatics,  artificial intelligence, machine learning,  high performance systems, reproducibility and science informatics.

AHMAD (MO) KHALIL

Associate Professor, Biomedical Engineering; Associate Director, Biological Design Center PhD, Mechanical Engineering, MIT

Synthetic & systems biology; gene regulation; protein aggregation; microbial communities; laboratory evolution.

CATHERINE KLAPPERICH

Professor, Biomedical Engineering; Director, Precision Diagnostics Center; PhD, Mechanical Engineering, University of California, Berkeley

Design of new molecular diagnostics and appropriate technologies for healthcare.

LAURA LEWIS

Assistant Professor, Biomedical Engineering; PhD, Neuroscience, Massachusetts Institute of Technology

Brain imaging; neural dynamics; computational neuroscience and signal processing; neural circuits underlying sleep and attention; decoding and predicting brain activity; neurovascular coupling; psychiatric and neurodegenerative disorders.

KENNETH R. LUTCHEN

Professor, Biomedical Engineering; Dean, College of Engineering

PhD, Biomedical Engineering, Case Western Airway and lung tissue mechanics and ventilation; Computational modeling of structure-function relations in the lung; Mechanical ventilation; Integrated biomechanics of the lung; linear and nonlinear systems identification; blood-glucose regulation.

JEROME MERTZ

Professor, Biomedical Engineering; Physics PhD, Physics, Université Paris VI and University of California, Santa Barbara

Development and application of new optical microscopy techniques to biological imaging.

JOHN NGO

Assistant Professor, Biomedical Engineering PhD, Biochemistry and Molecular Biophysics, California Institute of Technology

Protein structure and engineering; molecular and cellular engineering; single-molecule biophysics; cell signaling; fluorescence and electron microscopy.

HADI T. NIA

Assistant Professor, Biomedical Engineering

PhD, Mechanical Engineering, MIT

Tumor microenvironment; physical sciences of cancer; intravital imaging and animal models of cancer; mechanobiology and biomechanics.

TIMOTHY O’SHEA

Assistant Professor, Biomedical Engineering

PhD, Medical Engineering and Medical Physics, MIT

Glia Engineering, Biomaterials, Neural Engineering, Spinal Cord Injury, Stroke, Glial neurobiology, regenerative medicine, cell transplantation.

ERICA D. PRATT

Assistant Professor, Biomedical Engineering

PhD, Biomedical Engineering, Cornell University

Engineering-focused cancer research, Liquid biopsy and rare cell detection, Multi-Omics in oncology, Microfluidics and microfabrication, Pancreatic Cancer

DARREN ROBLYER

Associate Professor, Biomedical Engineering

Director of PhD Program Admissions

PhD, Bioengineering, Rice University

Optical functional imaging; diffuse optics; near infrared spectroscopy; monitoring of emerging targeted and cytotoxic therapies in oncology; non-invasive monitoring of tumor metabolism.

KAMAL SEN

Associate Professor, Biomedical Engineering Director of Master’s Program Admissions

PhD, Physics, Brandeis University

Electrophysiological recording of neural responses in auditory processing; theoretical methods to characterize neuronal encoding; computational models of natural sound processing.

ALLYSON SGRO

Assistant Professor, Biomedical Engineering

PhD, Chemistry, University of Washington

Developing a quantitative and predictive understanding of how cells coordinate their behavior and organize themselves as part of collectives by directly controlling cellular behavior and signaling.

MICHAEL L. SMITH

Associate Professor, Biomedical Engineering

PhD, Biomedical Engineering, University of Virginia

Cellular mechanotransduction through the extracellular matrix; fibronectin structural biology; and microfabricated surfaces for engineering cell function.

DIMITRIJE STAMENOVIĆ

Professor, Biomedical Engineering

PhD, Mechanics, University of Minnesota

Respiratory mechanics; cell mechanics; rheology of soft tissues; mechanics of foam-like structures.

Lecturers

BÉLA SUKI

Professor, Biomedical Engineering

PhD, Biomechanics, Jozsef Attila University, Szeged (Hungary)

Mechanical properties of living tissues; modeling the dynamic and nonlinear behavior of complex biological systems; pulmonary physiology.

JOE TIEN

Associate Professor, Biomedical Engineering

PhD, Physics, Harvard University

Vascularization of biomaterials; quantitative physiology of engineered tissues; biomaterials for microsurgical applications; lymphatics; interstitial transport; inverse problems in vascular imaging.

LUCIA M. VAINA

Professor, Biomedical Engineering; Neurology

PhD, Mathematical Logic, Sorbonne; Doctorat d’Etat ès Sciences and in Médecine (MD PhD); Institut National Toulouse, France

Behavioral, functional imaging (fMRI and MEG) and theoretical & computational approaches to study the neural basis and the plasticity of high-level visual functions in the human brain.

SANDOR VAJDA

Professor, Biomedical Engineering; Director, Biomolecular Engineering Research Center PhD, Chemistry, Hungarian Academy of Science

Scientific computing applied to problems in engineering, biochemistry, and biology, with focus on molecular mechanics, protein structure determination, protein-ligand interactions, docking, and drug design.

JOHN WHITE

Professor and Chair, Biomedical Engineering

PhD, Biomedical Engineering, Johns Hopkins University

Mechanisms of episodic memory; pathophysiology of epilepsy; computational neuroscience; design of real-time instrumentation; imaging of activity in neurons and astrocytes.

JOYCE WONG

Professor, Biomedical Engineering

PhD, Materials Science and Engineering, Program in Polymer Science and Technology, MIT

Biomaterials, tailoring cell-material interfaces for drug delivery and tissue engineering applications; direct, quantitative measurement of biological interactions.

WILSON WONG

Associate Professor, Biomedical Engineering PhD, Chemical Engineering, UCLA

Synthetic and systems biology in immune cells.

OUSAMA M. A’AMAR

Lecturer, Biomedical Engineering

Ph.D., with Distinction, Electrical Engineering, The National Polytechnic Institute of Lorraine (INPL), France EK131, EK210

XIN BROWN

Lecturer, Biomedical Engineering; Biointerface Technologies Facility Manager

PhD, Boston University School of Medicine BE209, BE605, BE726, BE727

MARIO CABODI

Master Lecturer, Biomedical Engineering

Director of Professional Master’s Programs

PhD, Cornell University BE694, BE695

ANDERSON (ICHUN) CHEN

Lecturer, Biomedical Engineering; Micro Nano Imaging Facility Manager

PhD, Applied Physics, Stevens Institute of Technology BE517

MUHAMMAD ZAMAN

Professor and Vice Chair, Biomedical Engineering PhD, Physical Chemistry University of Chicago

Comprehensive and quantitative approaches to develop a multiscale understanding of cell-matrix interactions for fundamental biological and applied clinical research.

WYNTER J. DUNCANSON

Lecturer, Biomedical Engineering; Assistant Dean of Outreach and Diversity

PhD, Biomedical Engineering, Boston University BE465, BE466

ANDY FAN

Lecturer, Biomedical Engineering

PhD, Electrical Engineering, MIT BE403, EK103, BE601, BE601, BE603, BE604, Mathematical Methods for Biomedical Engineering

KAVON KARROBI

Lecturer, Biomedical Engineering

BTEC Manager

Ph.D. Biomedical Engineering, Boston University BE492, BE465, BE466

ALEKSANDRS ZOSULS

Instructor, Biomedical Engineering

BS, Biomedical Engineering, Boston University EK210, EK307, BE491, BE492

Research Faculty Emeritus

ELIZABETH BARTOLAK-SUKI

Research Assistant Professor, Biomedical Engineering

MD, General Medicine, Szent-Gyorgyi Medical School, Szegred, Hungary; DSc, Molecular Cell biology, Semmelweis Medical School, Budapest, Hungary

Inter/intracellular signaling and molecular/ medical pathology.

DIMITRI BEGLOV

Research Assistant Professor, Biomedical Engineering

PhD, Molecular Biophysics, Moscow

Physical and Technical Institute

Computational chemistry and biology; protein structure and function; computational characterization and prediction of biomolecular interactions.

XIAOJUN CHENG

Research Assistant Professor, Biomedical Engineering

PhD, Physics, City University of New York Light scattering in the tissue and the development optical brain imaging techniques.

AARON COLBY

Research Assistant Professor, Biomedical Engineering

PhD, Biomedical Engineering, Boston University

Developing novel delivery systems including nanoparticles and drug concentrating devices as tools for treating cancer.

AURELIE EDWARDS

Research Professor, Biomedical Engineering

PhD, Chemical Engineering, MIT

Developing mathematical models of water and solute transport in the kidney, at different scales, to address physiological and pathological questions.

JEROEN EYCKMANS

Research Assistant Professor, Biomedical Engineering

PhD, Medical Sciences, KULeuven, Leuven, Belgium

Tissue repair and regeneration, wound healing biomechanics, biomimetic tissueon-chip models, skeletal organoid biology, reverse tissue engineering, fibrosis.

FERNANDO FERNANDEZ

Research Assistant Professor, Biomedical Engineering

PhD, Neuroscience, University of Calgary

Electrophysiology, biophysics and computational neuroscience; understanding the underlying mechanisms of neuronal electrical activity and its implications for synaptic integration and spike output modulation in cortical circuits.

ODED GHITZA

Research Professor, Biomedical Engineering

PhD, Electrical Engineering, Tel Aviv Univ.

Formulation of cortical computation principles that underlie the speech decoding process and that are capable of predicting human performance in speech perception tasks.

DMYTRO KOZAKOV

Research Associate Professor, Biomedical Engineering

PhD, Biomedical Engineering, Boston Univ. Development of protein-protein and protein-ligand docking algorithms, fast and efficient scoring functions for screening large number of potential docked complexes, protein homology. models suitable for docking.

NESE LORTLAR-ÜNLÜ, MD

Visiting Research Associate Professor, Biomedical Engineering

MD, Hacettepe University, Ankara, Turkey Optical characterization and nanophotonics.

BARBARA G. SHINN-CUNNINGHAM

Research Professor, Biomedical Engineering

PhD, EE and Computer Science, MIT Auditory neuroscience - binaural and spatial hearing.

BRIAN SNYDER

Research Professor, Biomedical Engineering

MD and PhD, Biomechanics, University of Pennsylvania

Basic and applied research in musculoskeletal biomechanics, cellular processes, and gene expression.

THOMAS L. SZABO

Research Professor, Biomedical Engineering

PhD, Physics, University of Bath, UK Medical imaging, diagnostic ultrasound, tissue characterization, transduction, biomedical signal processing, wave propagation, nonlinear acoustics.

MARTIN THUNEMANN

Research Assistant Professor, Biomedical Engineering

Eberhard-Karls-Universität Tübingen, Germany, Biochemistry, Dr. rer. nat. Cellular and systems-level neuroscience, microscopy, electrophysiology, preclinical imaging.

MERYEM YUCEL

Research Assistant Professor, Biomedical Engineering PhD, Biomedical Engineering, Boğaziçi University, Istanbul, Turkey  Functional neuroimaging (fNIRS, fMRI, EEG), fNIRS signal processing, cognitive neuroscience.

Adjunct Faculty

HERNAN JARA, PHD

Adjunct Associate Professor, Biomedical Engineering; Associate Professor of Radiology, BUSM

JULIO COLLADO VIDES, PHD

Adjunct Research Professor, Biomedical Engineering

JOSEPH LEHÁR, PHD

Adjunct Research Professor, Biomedical Engineering

CHRISTINE MCBETH, PHD

Adjunct Research Assistant Professor, Biomedical Engineering

CHARLES CANTOR, PHD

Professor Emeritus, Biomedical Engineering crcantor@bu.edu

H. STEVEN COLBURN, PHD

Professor Emeritus, Biomedical Engineering colburn@bu.edu

EVAN EVANS, PHD

Research Professor Emeritus, Biomedical Engineering cjd@bu.edu

MAXIM D. FRANK-KAMENETSKII

Professor Emeritus, Biomedical Engineering mfk@bu.edu

STEPHEN GROSSBERG, PHD

Professor Emeritus, Biomedical Engineering steve@bu.edu

TEMPLE F. SMITH, PHD

Professor Emeritus, Biomedical Engineering tsmith@bu.edu

Affiliated Faculty

MICHAEL ALBRO, PHD

Assistant Professor, Mechanical Engineering

MARGRIT BETKE, PHD

Professor, College and Grad School of Arts & Sciences, Computer Science

THOMAS BIFANO, PHD Professor, Mechanical Engineering; Materials Science & Engineering; Director, Photonics Center

DAVID BISHOP, PHD

Professor, Electrical and Computer Engineering; Physics; Materials Science & Engineering; Mechanical Engineering; Head, Div. of Materials Science & Engineering; Director, CELL-MET Engineering Research Ctr.

DAVID CENTER, MD Professor of Pulmonary Medicine, Medicine, and Biochemistry; Chief of Allergy, Pulmonary and Critical Care Medicine BUSM

CHANDRAMOULI CHANDRASEKARAN, PHD

Assistant Professor, Anatomy & Neurobiology; Psychological and Brain Sciences; Center for Systems Neuroscience

JERRY CHEN, PHD Assistant Professor, Biology

CHRISTOPHER CONNOR, MD, PHD Assistant Professor, Anesthesiology BUSM

QIANG CUI, PHD Professor, Chemistry

DOUGLAS DENSMORE, PHD Professor, Electrical and Computer Engineering

ANDREW EMILI, PHD Professor, Biology; Biochemistry; Director, Center for Network Systems Biology

SHYAMSUNDER ERRAMILLI, PHD Professor, Physics

JEFFREY GAVORNIK, PHD

Associate Professor, Biology

LEE GOLDSTEIN, MD, PHD

Associate Professor, Psychiatry; Neurology; Opthalmology; Pathology and Laboratory Medicine BUSM

FRANK GUENTHER, MS, PHD Professor, Sargent College, Speech Language and Hearing Science

JAMES A. HAMILTON, PHD Professor, Physiology and Biophysics BUSM

MICHAEL HASSELMO, PHD Professor, Biology; Director, Center for Systems Neuroscience

LAERTIS IKONOMOU, PHD Assistant Professor, Medicine BUSM

W. CLEMENT KARL, PHD Professor, Electrical and Computer Engineering

NANCY KOPELL, PHD Professor, Mathematics

DARRELL N. KOTTEN MD Professor, Medicine, BUSM Director, Center for Regenerative Medicine

ANN MCKEE, MD Professor, Neurology & Pathology, BUSM

S. HAMID NAWAB, PHD

Professor, Electrical and Computer Engineering

ELAINE O. NSOESIE, PHD

Assistant Professor, School of Public Health

PIETER NOORDZIJ, MD Professor, Medicine BUSM

GEORGE O’CONNOR, MD, MS Professor, Medicine BUSM

IOANNIS PASCHALIDIS, PHD

Professor, Electrical and Computer Engineering

TYLER PERRACHIONE, PHD

Associate Professor, Sargent College: Speech, Language & Hearing Sciences

STEVE RAMIREZ, PHD

Assistant Professor, Psychological & Brain Sciences

TOMMASO RANZANI, PHD

Assistant Professor, Psychological & Brain Sciences

Assistant Professor, Mechanical Engineering; Materials Science & Engineering

ROBERT M. G. REINHART, PHD

Assistant Professor, Psychological & Brain Sciences; Director, Cognitive & Clinical Neuroscience Laboratory

MICHELLE SANDER, PHD

Associate Professor, Electrical and Computer Engineering, Materials Science & Engineering

PANKAJ MEHTA, PHD Professor, Physics

ELISE F. MORGAN, PHD Professor, Mechanical Engineering

BENJAMIN SCOTT, PHD

Assistant Professor, Psychological and Brain Sciences

DANIEL SEGRÈ, PHD

Associate Professor, Biology

Affiliated Faculty Cont

SATISH K. SINGH, MD

Associate Professor, Gastroenterology BUSM

CARA STEPP, PHD

Professor, Sargent College, Speech, Language & Hearing Science

ROBERT A. STERN, PHD Professor, Neurology, Neurosurgery, and Anatomy; Neurobiology BUSM

LEI TIAN, PHD

Assistant Professor, Electrical and Computer Engineering

M. SELIM ÜNLÜ, PHD Professor, Electrical and Computer Engineering

ARTURO VEGAS, PHD Assistant Professor, Chemistry

DAVID WAXMAN, PHD Professor, Biology; BioInformatics; Medicine

ALICE WHITE, PHD Professor and Chair, Mechanical Engineering

ZEBA WUNDERLICH, PHD Assistant Professor, Biology

JI YI, PHD Assistant Professor, Medicine BUSM

KATHERINE YANHANG ZHANG, PHD Professor, Mechanical Engineering

XIN ZHANG, PHD

Professor, Mechanical Engineering; Electrical and Computer Engineering; Materials Science & Engineering

SENIOR POSTDOCTORAL ASSOCIATES

Afzal, Muhammad Imran (Devor)

Li, Huishan (Wong W)

POSTDOCTORAL ASSOCIATES

Alnahhas, Razan (Dunlop)

Andreadni, Virgile (Dunlop)

Angstman, James (Khalil)

Bays, Jennifer (Chen)

Beldzik, Ewa (Lewis)

Bowal, Kimberly (Larkin)

Chiesa, Guilio (Khalil)

Ching, Meining Carley (Zaman)

Dotson, Hannah (W Wong)

Drain, Allison (Chen)

Fomin-Thunmann, Natalie (Devor)

Frostig, Hadas (Mertz)

Gao, Yuanyua (Boas)

Hager, Emily (Sgro)

Jacob, Len (Lewis)

Jaswal, Rajneesh (Galagan)

Kays, Joshua (Dennis)

Kinstlinger, Ian (Wong W)

Klumpe, Heidi (Chen)

Kureli, Gulce (Boas)

Liang, Yong (Wong W)

Lowet, Eric (Han)

Lugagne, Jean-Baptiste (Dunlop)

McLellan, Micheal (Chen)

Moussa, Hagar (Khalil)

Moya, Maria (Economo)

Ngo, Mai (Chen)

Noueihed, Jad (White)

Orubu, Ebiowei (Zaman)

Parate, Kshama (Galagan)

Pham, Thao (Roblyer)

Ravikumar, Arjun (Khalil)

Raymond, Michael (Khalil)

Ricci-Tam, Chiara (Sgro)

Rosenbohm, Justin (Cobodi)

Shaw, William (Khalil)

Sundaram, Subramanian (Chen)

Teo, Jessica (Chen)

Tierrafria, Victor (Galagan)

Uroz, Marina (Chen)

Vayisoglu, Tugberk (Devor)

Wong, Brandon (Khalil)

SENIOR RESEARCH SCIENTISTS

Desai, Darash (Zaman)

Finkelstein, Joshua (Chen)

Kim, Jae (Vajda)

Kilic, Kivilcim (Devor)

RESEARCH SCIENTISTS

Buczek-Thomas, Joann (Wong, J)

Jiang, John (Boas)

Kim, Sudong (Chen)

Kondabolu, Krishnakanth (Han)

Tseng, Hua-an (Han)

Xiao, Sheng (Mertz)

Zimmerman, Bernhard (Boas)

RESEARCH TECHNICIANS

Anakwe, Stephanie (Lewis)

Charles, Roger (Galagan)

Diamandis, Zachary (Lewis)

Dubb, Jay (Boas)

Farzam, Parya (Boas)

Fuzail, Ahsan (Zaman)

Jadeja, Rohan (Bigio)

Kelleher-Tang, Laurie (Chen)

Kura, Sreekanth (Boas)

Lin, Wei (Roblyer)

Matta, Sidney (Economo)

Mlawer, Samuel (Connizzo)

Morales, Christian (J Wong)

Tucker, Stephen (Boas)

Ugarte Nunez, Juan (Economo)

Williams, Stephanie (Lewis)

Yee, Jessica (Lewis)

Zimmerman, Dabriel (Lewis)

Zhou, Samuel (Han)

Boston University’s Department of Biomedical Engineering

maintains a vibrant research program in its approximately 96,000 square feet of space on Boston University’s Charles River Campus. We are comprised of 38 separate research laboratories, and our faculty lead 8 research centers.

The research can be characterized by a combination of:

• Empirical and theoretical work with an attention to explicit mathematical models for the phenomena under study

• Intensive computer use for experimental and theoretical work

• A basic scientific flavor to the fundamental questions being asked

• An attention to the applications of improving health care, and a thorough understanding of the underlying physiological processes

• 4 Training Grants funding PhD students

7/1/21 - 6/30/22

118 new and continuing awards were funded.

$ 132 million in research proposals were submitted.

BME Faculty Annual Total Grant Funding

Research in the BME Department

BU BME Research Areas

We have world leaders in these areas of research:

• Biomechanics and Mechanobiology

• Synthetic and Systems Bioengineering

• Molecular-Cellular-Tissue Engineering

• Neural Engineering

Using the enabling technologies:

• Biomaterials

• Biomedical Imaging

• Computation Modeling and Data Sciences

• Nanotechnology and Sensing

BU Research Centers

BU has eight interdisciplinary research centers that are directed by BME faculty:

Bioengineering Technology and Entrepreneurship Center

Transforming education and innovation for bioengineering students through hands-on learning in partnership with industry, from gene editing to biosensors to digital medicine

Biological Design Center

To rigorously understand life’s design principles and re-engineer them to revolutionize our approach to addressing critical challenges in human health and the environment

Biomolecular Engineering Research Center

Developing and applying computational methods for the analysis and design of structures, functions,  interactions, regulation and evolution of biological macromolecules

Center on Forced Displacement

Fostering research and engagement with the global challenge of forced displacement, through multidisciplinary teams from across BU, around the country, and around the world

NSF Engineering Research Center in Cellular Metamaterials

Developing tissue-engineering principles to create scalable, low-cost technologies for growing clinically significant cardiac tissues from cell-level building blocks

Nanotechnology Innovation Center

Where nanomaterials intersect medicine and energy through collaborative interdisciplinary research

Neurophotonics Center

Advancing our understanding and treatment of brain disorders through advanced optical science and photonic systems

Precision Diagnostics Center

Discovery, design and development and clinical translation of technology for disease screening and monitoring, treatment management and health maintenance

BIGIO VALIDATION OF LIGHT SCATTERING SPECTROSCOPY FOR INTRA-OPERATIVE MARGIN GUIDANCE DURING ORAL CANCER RESECTION NIDCR (sub BMC) 180322

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BIGIO OPTIMIZATION AND VALIDATION OF QUANTITATIVE BIREFRINGENCE MICROSCOPY FOR ASSESSMENT OF MYELIN PATHOLOGIES ASSOCIATED WITH COGNITIVE IMPAIRMENTS AND MOTOR DEFICITS IN YOUNG AND OLD AGING MONKEY BRAIN NIA 569055

BOAS THE IMPACT OF MICROVASCULAR (DYS)REGULATION ON CEREBRAL FLOW AND OXYGEN HETEROGENEITY NINDS 620265

BOAS IMAGING AND ANALYSIS TECHNIQUES TO CONSTRUCT A CELL CENSUS ATLAS OF THE HUMAN BRAIN NIMH (sub MGH) 295122

BOAS TIME-GATED DIFFUSE CORRELATION SPECTROSCOPY FOR FUNCTIONAL IMAGING OF THE HUMAN BRAIN

(sub MGH)

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BOAS THE NEUROSCIENCE OF EVERYDAY WORLD- A NOVEL WEARABLE SYSTEM FOR CONTINUOUS MEASUREMENT OF BRAIN FUNCTION

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BOAS MULTISPECTRAL AND HYPERSPECTRAL PRECLINICAL IMAGER SPANNING THE VISIBLE, NIR-I AND NIR-II NIH/Office of the Director 404300

CHEN NOTCH SIGNALING AND ADHESION REGULATION NHLBI 825000

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CHEN LOCAL REGULATION OF ANGIOGENESIS BY MICROENVIRONMENT

CHEN NOVEL STRATEGIES TO UNDERSTAND, PREDICT, AND PREVENT VASCULAR TOXICITY OF TARGETED CML THERAPIES

(sub NEMC) 180781

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CHEN DEFINING GENETIC ARCHITECTURE AND PATHWAYS OF DCM NHLBI (sub Wyss Inst) 30380

CHEN MULTI-TISSUE PLATFORM FOR MODELING SYSTEMIC PATHOLOGIES NIBIB (sub Wyss Inst)

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CHENG UNVEILING THE MECHANISMS OF ULTRASOUND NEUROMODULATION VIA SPATIALLY CONFINED STIMULATION AND TEMPORALLY RESOLVED RECORDING

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CHENG SENSING VULNERABLE PLAQUE IN VIVO BY AN ALL-OPTICAL INTRAVASCULAR ULTRASOUND AND PHOTOACOUSTIC CATHETER

634489

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CHENG MAPPING CANCER METABOLISM BY MID-INFRARED PHOTOTHERMAL MICROSCOPY NCI 398440

CHENG UNVEILING THE MECHANISMS OF ULTRASOUND NEUROMODULATION VIA SPATIALLY CONFINED STIMULATION AND TEMPORALLY RESOLVED RECORDING

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CHENG METABOLIC ASSESSMENT OF ANTI-MICROBIAL SUSCEPTIBILITY WITHIN ONE CELL CYCLE

CHENG TARGETING LIPID UNSATURATION IN OVARIAN CANCER STEM CELLS

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CHENG HIGH-CONTENT HIGH-SPEED CHEMICAL IMAGING OF METABOLIC REPROGRAMMING BY INTEGRATION OF ADVANCED INSTRUMENTATION AND DATA SCIENCE

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COLLADO-VIDES A COMPREHENSIVE RESOURCE FOR ESCHERICHIA COLI GENOMIC DATA AND TOOLS

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CONNIZZO AGING AND INFLAMMATION IN THE ETIOLOGY OF COMPRESSION-INDUCED TENDON DEGENERATION NIA

CONNIZZO NON UNIFORMITY IN THE PDL: STRUCTURE AND FUNCTION OF THE DENSE COLLAR NIDCR (sub NEMC)

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DENNIS MULTIPLEXED IMAGING IN THE NEAR INFRARED WITH INDIUM PHOSPHIDE QUANTUM SHELLS NIGMS

DENNIS IN VIVO MAPPING OF ENZYME ACTIVITY USING SWIR-EMITTING, SELF-ILLUMINATING QUANTUM DOT SENSORS NIBIB 222750

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DEVOR EFFECTS OF INTRINSIC AND DRUG-INDUCED NEUROMODULATION ON FUNCTIONAL BRAIN IMAGING NIDA 382450

DEVOR MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGING NIMH 134300.3

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DEVOR UNDERSTANDING THE RELATIONSHIPS BETWEEN FUS-BBB OPENING, NEUROINFLAMMATION, AND THE NEUROVASCULAR RESPONSE NIBIB (sub BWH) 78776

DEVOR INTEGRATION OF HIGH DEFINITION DISPLAY TECHNOLOGIES WITH PLATINUM NANOROD MICROELECTRODES FOR LARGE SCALE IN-VIVO RECORDING AND STIMULATION NINDS (sub UCSD) 636423

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DEVOR LOCAL NEURONAL DRIVE AND NEUROMODULATORY CONTROL OF ACTIVITY IN THE PIAL NEUROVASCULAR CIRCUIT NINDS 5492099

DUNLOP CELL-TO-CELL HETEROGENEITY AND THE EMERGENCE OF ANTIBIOTIC RESISTANCE NIAID 412189

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DUNLOP QUANTIFYING CLOSTRIDIOIDES DIFFICILE SINGLE-CELL GROWTH DYNAMICS USING TIME-LAPSE ] MICROSCOPY NIAID (sub NEMC) 32111

ECONOMO REVERSE ENGINEERING THE BRAIN STEM CIRCUITS THAT GOVERN EXPLORATORY BEHAVIOR NINDS (sub UCSD) 95124

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ECONOMO LINKING MOTOR CORTEX ACTIVITY AND MOVEMENT IN THE MOUSE OROFACIAL SYSTEM. NINDS 412498

ECONOMO HIGH-THROUGHPUT MAPPING OF SYNAPTIC CONNECTIVITY BETWEEN TRANSCRIPTOMICALLY DEFINED CELL TYPES NIMH 1423833

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EYCKMANS DEVELOPMENT OF A WOUND-ON-CHIP MODEL TO STUDY STROMAL-EPITHELIAL INTERACTIONS DURING TISSUE REPAIR NIBIB 185625

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GALAGAN NOVEL BIOSENSORS BASED ON MINING BACTERIAL TRANSCRIPTION FACTORS NIBIB 655799

GREEN MODEL-GUIDED DESIGN OF RNA STABILIZING ELEMENTS FOR IMPROVED CORONAVIRUS DIAGNOSTICS NIBIB (sub ASU) 420000

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GREEN RAPID LOW-COST PAPER-BASED BIODOSIMETRY THAT REVEALS INDIVIDUAL ORGAN INJURIES NIAID (sub ASU) 143397

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SUPERHYDROPHOBIC DRUG LOADED BUTTRESSES FOR PREVENTION OF LUNG TUMOR RECURRENCE NCI 468259

GRINSTAFF OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA NCI 539833

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GRINSTAFF SULFATED POLY-AMIDO-SACCHARIDE (SULPAS) BIOMATERIALS AS ANTICOAGULANTS NHBLI 553824

HAN VOLTAGE IMAGING ANALYSIS OF STRIATAL NETWORK DYNAMICS RELATED TO VOLUNTARY MOVEMENT AND PARKINSONS DISEASE NINDS 477150

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HAN MULTIDIMENSIONAL OPTIMIZATION OF VOLTAGE INDICATORS FOR IN VIVO NEURAL ACTIVITY IMAGING NIMH

KHALIL EPACE: AN AUTOMATED SYSTEM FOR HIGH-THROUGHPUT, CLOSED-LOOP CONTROL OF CONTINUOUS MOLECULAR EVOLUTION TO ENABLE NOVEL THERAPEUTICS NIBIB 612043

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KHALIL SYNTHETIC TOOLKIT FOR PRECISION GENE EXPRESSION CONTROL AND SIGNAL PROCESSING IN MAMMALIAN CELLS NIBIB 675046

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KHALIL PROGRAMMABLE BENCHTOP BIOREACTORS FOR SCALABLE ECO-EVOLUTIONARY DYNAMICS OF THE HUMAN MICROBIOME NIAID 867648

KLAPPERICH FLIPPED BIOMEDICAL GRAND ROUNDS: CREATING A CLINICAL IMMERSION CLASSROOM NIBIB 21600

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LEWIS DEVELOPMENT OF THE HUMAN DYNAMIC NEUROCHEMICAL CONNECTOME SCANNER NIBIB (sub MGH) 36954

LEWIS SLEEP-DEPENDENT MODULATION OF CEREBROSPINAL FLUID FLOW IN AGING AND ACROSS GENETIC RISK FOR ALZHEIMER’S DISEASE NIA 695231

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LEWIS NEUROIMAGING THE IMPACT OF RESPIRATION AND RESPIRATORY-GATED NEUROMODULATION ON HUMAN GLYMPHATIC PHYSIOLOGY NCCIH 666351

LEWIS FMRI TECHNOLOGIES FOR IMAGING AT THE LIMIT OF BIOLOGICAL SPATIOTEMPORAL RESOLUTION NIBIB (sub MGH) 145162

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LEWIS A CONNECTOME-BASED CLINICAL TRIAL PLATFORM TO PROMOTE EARLY RECOVERY OF CONSCIOUSNESS AFTER TRAUMATIC COMA NICHD (sub MGH) 41942

MERTZ FAST, LARGE-SCALE NEURONAL IMAGING WITH MULTI-Z CONFOCAL MICROSCOPY NIBIB

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MERTZ MULTI-LAYER NEURONAL IMAGING WITH REVERBERATION MULTIPHOTON MICROSCOPY NINDS

MERTZ ULTRAFAST HIGH-CONTRAST VOLTAGE IMAGING IN FREELY MOVING ANIMALS NINDS

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NGO INTEGRATIVE APPROACHES FOR PROBING CELL MECHANOTRANSDUCTION IN HEALTH AND DISEASE NIGMS

NIA CLASSIFYING MALIGNANT PULMONARY NODULES USING BIOPHYSICS-ENHANCED ARTIFICIAL INTELLIGENCE NIBIB

ROBLYER LABEL-FREE MEASUREMENT OF BLOOD LIPIDS WITH HYPERSPECTRAL SHORT-WAVE INFRARED SPATIAL FREQUENCY DOMAIN IMAGING TO IMPROVE CARDIOVASCULAR DISEASE RISK PREDICTION AND TREATMENT MONITORING

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ROBLYER FREQUENCY DOMAIN DIFFUSE OPTICAL SPECTROSCOPY AND DIFFUSE CORRELATION SPECTROSCOPY FOR ASSESSING INSPIRATORY MUSCLE METABOLISM IN MECHANICALLY VENTILATED PATIENTS NIBIB

ROBLYER FREQUENCY DOMAIN SHORTWAVE INFRARED SPECTROSCOPY (FD-SWIRS) FOR VOLUME STATUS MONITORING DURING HEMODIALYSIS IN END STAGE KIDNEY DISEASE NIDDK

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SGRO CONNECTING SINGLE-CELL SIGNALING DYNAMICS TO MULTICELLULAR DECISION MAKING NIGMS

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SUKI A MULTI-SCALE COMPUTATIONAL MODEL OF THE EXTRACELLULAR MATRIX OF THE LUNG NHLBI

VAJDA ANALYSIS AND PREDICTION OF MOLECULAR INTERACTIONS

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WONG W ADVANCED RECOMBINASE-BASED GENE EXPRESSION TECHNOLOGY IN MAMMALIAN CELLS NIGMS

WONG W PRECISE TUMOR TARGETING WITH LOGIC CAR CIRCUITS

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WONG W ADVANCED RECOMBINASE-BASED GENE EXPRESSION TECHNOLOGY IN MAMMALIAN CELLS

WONG W MULTIPLEXED AND LOGICAL CONTROL OF THE MAMMALIAN TRANSCRIPTOME USING CAS13

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WONG W TARGETING FIBROBLAST DISCOIDIN DOMAIN RECEPTOR 2 FOR IMMUNOTHERAPY TO PULMONARY FIBROSIS NHLBI (sub U Michigan)

WONG W PRECISE TARGETING OF T1D SPECIFIC T CELLS USING CAR AND PEPTIDE-MHC CHIMERIC ANTIGEN LIGANDS NIDDK

WONG J THE BOSTON UNIVERSITY KIDNEY AND MEDICAL ENGINEERING PROGRAM (BU-KIDMEP)

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DUNLOP TRANSITIONS: DEEP LEARNING MODELS FOR MICROBIAL IMAGE ANALYSIS AND TIME-SERIES PREDICTIONS

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HAN COLLABORATIVE RESEARCH: DYNAMIC INTERACTIONS OF INDIVIDUAL NEURONS IN SUPPORTING HIPPOCAMPAL NETWORK OSCILLATIONS DURING BEHAVIOR

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ROBLYER EFRI CEE: OPTICALLY CONTROLLED LOCALIZED EPIGENETIC CHROMATIN REMODELING WITH PHOTOACTIVATABLE CRISPR-DCAS9

CHEN SCIENCE AND TECHNOLOGY CENTER FOR ENGINEERING MECHANO-BIOLOGY

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CHEN NANOSYSTEMS ENGINEERING RESEARCH CENTER FOR DIRECTED MULTISCALE ASSEMBLY OF CELLULAR METAMATERIALS WITH NANOSCALE PRECISION: CELL-MET

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Awards from Industry

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ZAMAN APTAMER DEVELOPMENT FOR THE PHARMACHK PLATFORM Merck KGaA (Germany) 150000

ROBLYER ESTIMATING BLOOD PRESSURE CHANGES USING LASER SPECKLE CONTRAST MEASUREMENTS ON THE WRIST AND HAND Facebook 369264

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GREEN INTERCEPTING THE CELL’S HIDDEN SIGNALS VIA PEPTIDE-ACTIVATED RNA SWITCHES Research Corporation for Science Advance 55000

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BOAS COMPARING LASER SPECKLE CONTRACT AND DIFFUSE CORRELATION SPECTROSCOPY MEASUREMENTS IN HUMAN BRAIN FUNCTION Facebook 23000

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GRINSTAFF BIOADHESIVE FORM IN PLACE PATCH DEVELOPMENT

GRINSTAFF NOVEL ANTIBODY-DRUG CONJUGATES FOR SQUAMOUS CELL CARCINOMA TREATMENT

Boston Scientific Corp. 65137

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NIA CELLULAR RESOLUTION IMAGING OF DRUG DELIVERY INTO TUMORS IN FUNCTIONING EX VIVO LUNG Johnson & Johnson Enterprise Innovation 250000

WONG W EVALUATING NOT-GATED CARS IN NK CELLS Senti Biosciences 241671

KHALIL DESIGN AND IN VIVO COMPARISON OF ALTERNATIVE STRATEGIES FOR ARTIFICIAL ZINC FINGER Novartis Institutes for (AZNF) BASED REGULATABLE GENE THERAPIES

KHALIL SEMI-CONTINUOUS EVOLUTION OF DNMT3A/L-BINDING NANOBODIES FOR TARGETED EPIGENOME EDITING

Medicine, Inc. 260047

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CHENG AN INFRARED PHOTOTHERMAL PHASE MICROSCOPE FOR HIGH-RESOLUTION CHEMICAL Leonardo DRS Daylight IMAGING IN FINGERPRINT REGION Solutions 216972

CHENG IMAGING BREAST TUMOR BY A

Awards from Other Government Agencies

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DIAL-A-THREAT YEAR 2

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KHALIL DRAPER TEAM FELIX PROPOSAL

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PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF A’AMAR

WONG J BIOMATERIALS SCIENCE AND ENGINEERING APPROACH FOR LOCAL PROGESTERONE INACTIVATION

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SHAW DECIPHERING GENETIC AND EPIGENETIC REGULATION IN EUKARYOTIC GENE CLUSTERS USING SYNTHETIC GENOMICS

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CHEN ENGINEERING HIGH DENSITY FUNCTIONAL VASCULAR, LYMPHATIC, AND DUCTAL TREES

Awards from Foundations

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ECONOMO THE DESCENDING CONTROL OF MOVEMENT INITIATION BY THE MOTOR CORTEX THE ESTHER A. & JOSEpH KLINGENSTEIN

ECONOMO INVESTIGATING THE CONTROL OF MOVEMENTS BY SuBSpACES AND CELL TYpES IN THE MOuSE OROFACIAL SYSTEM WHITEHALL FOuNDATION, INC 75000

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ZAMAN FELLOWSHIp IN QuALITY OF MEDICAL pRODuCTS AT BOSTON uNIVERSITY uS pHARMACOpEIAL CONVENTION 138855

ZAMAN EVALuATION OF FEASIBILITY FOR GRAND CHALLENGES pAKISTAN pARTNERSHIp II BILL & MELINDA GATES FOuNDATION 330199

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ZAMAN DOCuMENTING uNICEF’S WORK IN HEALTH SECTOR IN HuMANITARIAN SETTINGS uSING MODELLING, YR2 uNITED NATIONS CHILDREN S FuND 35000

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O’SHEA pROMOTING GLIA-BASED REpAIR IN SpINAL CORD INJuRY BRYON RIESCH pARALYSIS FOuND. 60000

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O’SHEA GLIA REpAIR OF CHRONIC SCI LESION CORES BY A SEQuENTIAL ENZYMATIC DEBRIDEMENT AND CELL GRAFTING STRATEGY WINGS FOR LIFE 220000

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LEWIS SpI STEVENS: GLIAL MECHANISMS BY WHICH SLEEp pRESERVES COGNITIVE FuNCTION AND pLASTICITY IN AGING SIMONS FOuNDATION 250000

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LEWIS HARVARD uNIVERSITY/MASSACHuSETTS INSTITuTE OF TECHNOLOGY JOINT RESEARCH GRANT pROGRAM IN BASIC NEuROSCIENCE HARVARD 23487

LEWIS SuBCORTICAL CIRCuIT DYNAMICS uNDERLYING HuMAN SLEEp AND WAKEFuLNESS THE pEW CHARITABLE TRuSTS 300000

LEWIS IMAGING ELECTROpHYSIOLOGICAL AND FLuID DYNAMICS IN THE SLEEpING BRAIN THE MCKNIGHT FOuNDATION 75000

ROBLYER A WEARABLE pROBE FOR DEEp TISSuE IMAGING OF HEMODYNAMICS IN BREAST TuMORS ACS 360000

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DENNIS DEEp TISSuE pHOTOACOuSTIC IMAGING WITH DEGRADABLE INORGANIC NANOpARTICLES SILICON VALLEY COMMuNITY (SCIALOG-DENNIS) FOuNDATION 57500

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NIA CLARE BOOTHE LuCE GRADuATE FELLOWSHIp FOR GABRIELLE GRIFNO THE HENRY LuCE FOuNDATION, INC 88654

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NIA DEVELOpMENT OF CRYSTAL RIBCAGE FOR IMAGING OF FuNCTIONING LuNG AT HIGH THE ARNOLD AND MABEL SpATIOTEMpORAL RESOLuTION BECKMAN FOuNDATION 150000

GRINSTAFF RELAXIN-2 AS A NOVEL INTRA-ARTICuLAR THERApEuTIC FOR ARTHROFIBROSIS BLAVATNIK FAMILY FOuNDATION (SuB BIDMC) 79455

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WONG W ENGINEERING BRANCHING NETWORKS THROuGH SYNTHETIC TuRING MORpHOGEN CIRCuITS ALLEN INSTITuTE D/B/A THE pAuL G. ALLEN 1300000

KHALIL SCHMIDT SCIENCE pOLYMATH AWARD THE ERIC AND WENDY SCHMIDT FuND FOR STRATEGIC INNOVATION 500000

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uROZ MARIMON MELANOMA VESSEL CO-OpTION IN BRAIN METASTASIS AHA 69446

CHEN GEOMETRIC AND MECHANICAL pATTERNING OF HIERARCHICAL VASCuLAR NETWORKS uNITED STATES - ISRAEL BINATIONAL SCIENC 33750

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HAGER uSING NATuRAL VARIATION AND CELLuLAR SLIME MOLDS TO uNCOVER COLLECTIVE CELL SIMONS FND (SuB LIFE SIGNALING RuLES (SIMONS FOuNDATION

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Awards for Student Support

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Graduate Enrollment

ENROLLMENT FOR AY 2021-2022

GRADUATE PROGRAM POPULATION

g MEng

g PhD

g MD/PhD

g MS

GRADUATE FUNDING AY 2021-2022

DEGREES AWARDED

ADMISSION RESULTS FOR AY 2020-2021

ADMISSION RESULTS FOR AY 2021-2022

MATRICULATIONS

MEng

PHD Graduates MENG Graduates

SEPTEMBER 25, 2021

Samantha Marie Berry (Mark Grinstaff, PhD Advisor)

“Supramolecularly Assembled Antibody Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer”

Israel Tilahun Desta (Sandor Vajda, PhD Advisor)

“Machine Learning and Template Based Modeling for Improving and Expanding the Functionality of Rigid Body Docking”

Yunpeng Feng (Arturo Vegas, PhD Advisor)

“Synthesis and Evaluation of Polymer Mosaics as Highly Tunable Biomaterials for Biomedical Applications”

Catherine Anne Gormley (Joyce Wong, PhD Advisor)

“Targeted Semi-Polymerized Shell Microbubbles for Detection of Early Post-Surgical Abdominal Adhesions”

Matti David Tyry Groll (Cara Stepp, PhD Advisor)

“The Quantitative Assessment of Laryngeal Physiology”

Haonan Lin (Ji-Xin Cheng, PhD Advisor)

“Stimulated Raman Spectroscopic Imaging: Data Science Driven Innovations and Applications”

Christos Michas (Christopher Chen and Alice White, PhD Co-Advisors)

“High-Precision Fabrication Enables On-Chip Modeling with OrganLevel Structural and Mechanical Complexity”

Justin Michael Rosenbohm (Catherine Klapperich, PhD Advisor)

“Qualitative and Semiquantitative Isothermal Detection of Nucleic Acids for Point-of-Care Testing Applications”

Smrithi Sunil (David Boas, PhD Advisor)

“Wide-Field Optical Imaging of Neurovascular Coupling During Stroke Recovery”

JANUARY 25, 2022

Cameron James Condylis (Jerry Chen, PhD Advisor)

“Cell Type-Specific Encoding and Routing of Sensory Information in Mouse Primary Somatosensory Cortex During Behavior”

Megan Elizabeth Egbert (Sandor Vajda, PhD Advisor)

“Detection and Analysis of Binding Sites and Protein-Ligand Interactions”

Joshua Christian Kays (Allison Dennis, PhD Advisor)

“Towards the Clinical Translation of Quantum Dots: Current Preclinical Barriers and Future Strategies”

Jeffrey Blye McMahan (John Ngo, PhD Advisor)

“Post-Translational Control Schemes in the Regulation of Synthetic Cellular Signaling via Engineered Notch Receptors”

Bahar Rahsepar (Steve Ramirez and John White, PhD Co-Advisors)

“Novel Strategies for the Modulation and Investigation of Memories in the Hippocampus”

Juliann Brina Tefft (Christopher Chen, PhD Advisor)

“The Impact of Perivascular Cells on Vascular Morphogenesis and Stability”

MAY 22, 2022

Hannah Lin Dotson (John Ngo, PhD Advisor)

“Chemogenetic Control of Gene Expression and Protein Function with Small Molecules”

Samuel Joseph Ghilardi (Allyson Sgro, PhD Advisor)

“Investigation and Control of Dermal Fibroblast Signaling During Injury Repair”

Gwendolyn Ann Hoffmann (Michael Smith and Joyce Wong, PhD Co-Advisors)

“Mechanically Active and Tunable Extracellular Matrix Fibers”

Seunghee Lee (Wilson Wong, PhD Advisor)

“Engineering Inhibitory Chimeric Antigen Receptor for Adoptive T Cell and NK Cell Therapy”

Justin Henry Letendre (Wilson Wong, PhD Advisor)

“Genetic Circuit Designs to Improve Synthetic Biological Signaling in Mammalian Cells”

Jad Noueihed Noueihed (John White, PhD Advisor) “Unsupervised Tracking and Automated Analysis of MultiPopulation Neural Activity Under Anesthesia”

Sanaya Ness Shroff (Xue Han, PhD Advisor)

“Optimization and Application of a High- Performance GeneticallyEncoded Fluorescent Sensor for Membrane Voltage Imaging”

Shannon Nicole Tunney (John Ngo, PhD Advisor) “Construction of Molecular Tools through Protein Excision and Splicing”

Dana Zemel (Xue Han, PhD Advisor)

“Pathological Neural Circuit States of the Dorsal Striatum in Parkinson’s Disease”

SEPTEMBER 25, 2021

Mercedes Suazo

MAY 22, 2022

Angela Maria Abrego Chavez

Thomas Clark Bohac

Rana Boustany

Sophia Grace Brocoum

Donivyn Cruz

Graham Edward Fullerton

Aideen Gill

Ellen Larson

Joel Stewart Miller

Kameron James Moore

Julia Pasco-Anderson

Ronak S. Shah

Acacia Thunder Tam

Elizabeth Grace Thaman

Claire Tourkin

Niketh Sam Vellanki

Hallie L. Wyles

Qian Xu

MS Graduates

SEPTEMBER 25, 2021

Bilal Syed Ahmed (Muhammad Zaman, MS Thesis Advisor)

“Development for a Blood Separation Method for Low- and Middle-Income Countries”

Danyal Fareed Bhutto (David Boas and Matthew Rosen, PhD Co-Advisors)

“From Optimal Experimental Design to Solving Inverse Problems for Various Imaging Modalities: Analyzing the Applicability and Robustness of Manifold Learning”

Caroline Margret Blassick (Mary Dunlop, PhD Advisor)

“Single-Cell Optogenetic Selection and Activation of Engineered Escherichia coli Transcription Factors for the Characterization and Prediction of Gene Regulatory Network Dynamics”

Emma Penelope Bortz (Xue Han, PhD Advisor)

“Strategies for Effective Ultrasound Neuromodulation”

Patrick Robert Doran (Anna Devor, PhD Advisor)

“Simultaneous Optical Imaging of Neuronal Activity and fMRI in Behaving Mice”

Carlos Augusto Gomez (Darren Roblyer, PhD Advisor)

“Combined Diffuse Optical Spectroscopy and Diffuse Correlation Spectroscopy Towards Monitoring of Inspiratory Muscle Metabolism of Mechanically Ventilated Patients”

Daniel James Hart Jr (Mo Khalil, PhD Advisor)

“Automated Atmospheric Control of Microbial Growth with Atmostat eVOLVER”

Liam Jackson (Frank Guenther, MS Mentored Project Advisor)

“Exploring the Significance of Electrocorticography Data with Machine Learning”

Jack Rainier Kirsch (Mark Grinstaff, PhD Advisor)

“Multimodal Delivery of Relaxin-2 for the Treatment of Arthrofibrosis”

Alex Andrew Lammers (Christopher Chen, PhD Advisor)

“Elucidating Mechanisms for Rapid Vascularization by Mimicking Vascular Islands in Early Embryogenesis”

Erin Elizabeth Landry

Yiting Liu (Aurelie Edwards, MS Mentored Project Advisor)

“Python-Based Model of Proximal Tubule Function”

Adam Gordon Sanford (Mo Khalil, PhD Advisor)

“Scalable, Continuous Directed Evolution of Nanobody-Based GPCR Agonists”

Mark Paladin Suprenant (Muhammad Zaman, PhD Advisor)

“Understanding the Link Among Diarrheal Diseases, Antimicrobial Resistance and Nutrition for the Improvement of Childhood Lives in Humanitarian Crisis”

Indorica Sutradhar (Muhammad Zaman, PhD Advisor)

“Quantitative Model of the Development of Antibiotic Resistant Bacterial Populations in Wastewater Settings”

Shane Howard Wright

Sue Shuyi Zhang (Mark Grinstaff and Hadi Nia, PhD CoAdvisors)

“Probing the Physical Tumor Microenvironment”

JANUARY 25, 2022

Kavindu Amarasinghe (Bela Suki, MS Mentored Project Advisor)

“Assessment of Microfluidic Flow Chamber for Analyzing Shear Moduli of Various Agarose Gel Samples”

Pierre Boucher (Chandramouli Chandrasekaran, MS Thesis Advisor)

“Gain Signal Manifest in Prestimulus Neural Population Dynamics Underlies Decision-Making”

Zahava Miriam Hirsch (Muhammad Zaman, MS Mentored Project Advisor)

“Modeling Access to IHS Healthcare for Rosebud Sioux Tribe Living on the Rosebud Indian Reservation”

Brendan Leap (David Boas, MS Mentored Project Advisor)

“bNIRDS Data Analysis”

Yue Liu

(Michael Albro, MS Mentored Project Advisor)

“Culture Media Replenishment Is Not Required to Generate Functional Engineered Cartilage in vitro”

Monica Martinez

(James Galagan, MS Thesis Advisor)

“Microbial Screening for Melatonin Responsive Enzymes”

Jacob Norman (John White, PhD Advisor)

“Investigating the Neuronal Basis of Engram Reactivation”

Rachel Lindsay Passaro (Hadi Nia, MS Mentored Project Advisor)

“Modelling Solid Stress in vitro with Cancer Spheroids”

Nicole Amber Rinaldi

Zian Wang (Ji-Xin Cheng, MS Mentored Project Advisor)

“Rapid Antifungal Susceptibility Testing (AFST) by Spectroscopic Stimulated Raman Scattering (SRS) Imaging of D2O Metabolism”

Hanrong Ye (Mo Khalil and Joyce Wong, PhD CoAdvisors)

“Infection Control and Immune Modulation with Monocyte-Targeting Nanoparticles and MacrophageBased Cell Therapy -- a Dual-Pronged Intervention System for Tuberculosis (TB)”

Jing Zhang (Ji-Xin Cheng, PhD Advisor)

“Single-Cell Analysis: From Phenotype to Genotype”

MAY 22, 2022

Rohin Banerji (Hadi Nia, PhD Advisor)

“Design, Development, and Validation of a Novel Crystal Ribcage to Study the Mechanobiology of Functioning Lung in Health and Disease at High Spatiotemporal Resolution”

Marcus W. Blackburn

(Mike Economo and Gabriel Ocker, MS Mentored Project Co-Advisors)

“Investigating Burst-Multiplexing in Visual Stimulus Encoding”

Xiaojie Chen

(Anna Devor, MS Thesis Advisor)

“Using Neurophotonic Tools to Access the Effects of Repeated BloodBrain-Barrier Opening with Focused Ultrasound”

Ramtin Jadbabaei Behbahan (Mark Grinstaff, MS Mentored Project Advisor)

“Synthesis, Optimization, and Characterization of Paclitaxel, Pt(IV) Cisplatin Prodrug, and Verticillin-A Expansile Nanoparticles (eNP) for Treatment of Epigenetically Resistant Mesothelioma”

Vibhav Jha

(Kamal Sen, MS Mentored Project Advisor)

“Decoding Spatial and Auditory Attention Using fNIRS and EEG

Simultaneously: Protocol, Cap Design and Analysis”

Sophia Kuipa

Uros Kuzmanovic

(James Galagan, PhD Advisor)

“Mining Metagenomes to Engineer Novel Hormone Biosensors”

Maximillian J Rozenblum

Alex Joseph Seibel (Joe Tien, PhD Advisor)

“Tissue-Engineered Human Lymphatic Models for the Study of Breast Cancer and Lymphatic Drainage”

Chenxin Sun

(Michelle Sander and Panagis Samolis, MS Mentored Project Co-Advisors)

“Photothermal Imaging of Mouse Glioblastoma Tumor Tissues”

Winnie Wang

(Jeroen Eyckmans, MS Thesis Advisor)

“Development of a Synthetically Modified Fibronectin Fragment as a Building Block for Recyclable Biomaterials”

Weerathunga Arachchige Hasini

Rathsara Weerathunge

(Cara Stepp, PhD Advisor)

“Sensorimotor and Kinematic Characterization and Modeling of Speech Motor Control in Individuals with Speech Disorders”

GRADUATE STUDENT AWARDS AND FELLOWSHIPS

Clare Boothe Luce Fellowship: Gabrielle Grifno

Dean’s Fellowships: Aarohi Mehendale, Leo Steiner

Distinguished BME Fellowships: Mohammed Abumuaileq, Alexander Boyd, Morgan Cambareri, Dhimiter Cobani, Emily Davis, Jingwen Deng, Maren Eltze, Harrison Fisher, Joseph Hall, Xingyu Hu, Zhuoying Huang, Mackenzie Hyman, Yixin Mei, Arun Nambiar, Kirk Pierce, Aidan Riley, Andrea Rosado-Quinones, Colin Skeen, Haochen Wan, Paige Woods, Hao Zang

F31 Fellowships: Jourdan Ewoldt, Gwendolyn Hoffman, Alex Lammers, Justin Letendre, Rebecca Mount, Sanaya Shroff

Kilachand Fellowships: Cristian Coriano-Ortiz, Daniel Hart, Xinwen Zhu

MLK Fellowship: Joshua Dupaty

NIH Quantitative Biology and Physiology T32 Fellowships: Diana Arguijo Mendoza, Sydney Bailes, Jack Cardini, Juan Jaramillo Montezco, Christopher Kuffner, Joshua Levitt, Carolyn Marar, Dev Mehrotra, Jack Vincent, McKayla Vlasity

NIH Synthetic Biology and Biotechnology T32 Fellowships: Sophia Kuipa, Noshin Nawar, Ezira Yimer Wolle

NIH Translational Research in Biomaterials T32 Fellowships: Eric Bressler, Alanna Farrell, Samantha Fletcher, Zoe Garman, Joshua McGee

NSF Graduate Research Fellowships: Danyal Bhutto, Caroline Blassick, Emma Bortz, Christian DeMoya, Padric Garden, Ariane Garrett, Carlos Gomez, Alison Lanzi, Alexander Marzilli, Christine McKee, Cara Ravasio, Emma Stowe

NSF Neurophotonics National Research Traineeship Program Fellowships: De’Ja Rogers

Society for Lab Automation & Screening Graduate Fellowship: David McIntyre

Mammalian Synthetic Biology Workshop (Talk): Menna Siddiqui

Acoustical Society of America, Raymond H. Stetson Scholarship, Honorable Mention: Hasini Weerathunge

NSF STTR Phase I Award: Uros Kuzmanovic

TiE University Regional Pitch Competition 1st Place Winner: Uros Kuzmanovic

M2D2 $200K Challenge 1st Place Winner: Uros Kuzmanovic

TiE University Global Pitch Competition 1st Place Winner: Uros Kuzmanovic

Hatch@Nest.Bio Award Winner: Uros Kuzmanovic

Northeast Bioengineering Conference 2022 (Poster): Yoseph Dance

National Institutes of Health/National Cancer Institute Cancer Tissue Engineering Collaborative Investigators Meeting (Poster/ Presentation): Yoseph Dance

WHS Annual Meeting 2022 (Talk): Megan Griebel

QBP/TRB/SB2 Graduate Research Symposium: Speakers - Nate Blanke, Mitch Clough, Yoseph Dance, Zachary Heins, Joshua Kays, Rebecca Mount Posters - Sydney Bailes, Emma Bortz, Christian DeMoya, Carlos Gomez, Jack Kirsch, Chris Kuffner, Josh Levitt, Carolyn Marar, Indorica Sutradhar, Sue Zhang

ENROLLMENT FOR AY 2021-2022

588 STUDENTS in the BME program 34% of the College of Engineering

COLLEGE OF ENGINEERING SELECTIVITY FOR AY 2021-2022

41% INCREASE in selectivity over 9 years

30% Selectivity

BME TEACHING HISTORY - AY 2021-2022

89 COURSES TAUGHT

40 PRIMARY FACULTY

$52 MILLION in research funding

10,101 total student credit hours

Undergraduate Degrees Awarded

BS DEGREES BREAKDOWN - AY 2021-2022

The Department awarded 126 BACHELOR OF SCIENCE DEGREES 28% of all the BS degrees awarded by the College of Engineering.

TRACKING ALUMNI

91% EMPLOYED or ENROLLED IN GRADUATE SCHOOL of 2020-2021 graduates

MMEDIC

M MEDIC

POST GRADUATION PLANS - 2019-2020 BME GRADUATES

EMPLOYED

GRADUATE/PROFESSIONAL SCHOOL

The College of Engineering conducts an exit survey of all graduating seniors in late April/ early May and continues to compile data until the end of the following fall semester. The results of these interviews are shown in the chart at left for the graduating class of May 2021 and are collected approximately six months after graduation.

Transitional Jobs/Travel/Still Looking

The Modular Medical/Dental Integrated Curriculum (MMEDIC) is a competitive early selection program that leads to a BS in Engineering and an MD from the Medical School. This program is offered and administrated in collaboration with our School of Medicine and is designed to train biomedical engineers who have the MD as their ultimate degree objective. MMEDIC admits to the School of Medicine a small number of highly qualified students who have completed two years of the premedical option of the biomedical engineering curriculum. The program is not designed to accelerate the engineering or the medical training but rather to effect a better transition from undergraduate engineering study to graduate medical training. The BS in Biomedical Engineering is normally earned after 4 years of undergraduate study and the MD after an additional 4 years of study at the Boston University Medical School.

Undergraduate Student Awards

In 2022, several of the BME seniors were recognized for achievements and contributions to the Boston University community and BME profession.

Adam M. Miller Memorial Award:

Awarded by the Biomedical Engineering Department to the graduating senior who has best advanced the reputation and prestige of the department through his/her involvement in department, college, university, professional activities, or organizations, as well as through the academic and senior project programs. This year the award was presented to Jodee Frias.

Engineering Alumni Association Student Leader Award:

Presented to seniors who have made outstanding contributions to the College and University through their involvement in activities and organizations. The 5 award winners this year are Rosangel Ramos Espinoza , Jodee Frias, Meghan Howard, Maria Lazou and Ethan Strauther

Student Advisor Service Awards:

Among the ENG winners for outstanding assistance in advising this year, the following BME seniors were recognized: Robert Bing, Jeonghoon Choi, Elizabeth Hanchar, Emily Hill, Maria Lazou, Laura Mazuera, Christianna Roggeveen, Olivia Claire Rose, Blaire Smith, Ethan Strauther, Rishi Vaidya and Rohun Yarala

Undergraduate Student Service Award:

Outstanding Senior Project Award:

This year’s award winner is BME senior Olivia Claire Rose.

First Place in the Department’s 2022 Outstanding Senior Design Project Award went to Mackenzie Obenreder and Christianna Roggeveen for their project “Developing placenta-on-a-chip model to test drug transfer at the maternal-fetal interface”, under the supervision of Robert Gaibler (Draper) and Corin Williams (Draper).

Societal Impact Capstone Project Award:

Second Place in the Department’s 2022 societal Impact Capstone Project Award went to Cecile Meier-Scherling and Taylor Schissel for their project “Systems analysis and modeling to improve access to healthcare among Native American Communities in Rosebud, SD”.

Undergraduate Student Organizations

Boston University Student Chapter of the Biomedical Engineering Society

The purpose of the Biomedical Engineering Society is: “To promote the increase of biomedical engineering knowledge and its utilization.” The student chapter at Boston University works towards this goal in all of its activities. The Biomedical Engineering Society provides a focus for community building among BME students with activities which strengthen their understanding of and interest in Biomedical Engineering. The Society provides students with literature, field trips, films and guest lectures, which provide them with a “resource center” concerning such vital areas as career opportunities and graduate study in Biomedical Engineering.

BMES Officers AY 2021-2022

President – Rishi Vaidya ‘22

Vice President – Simrita Dhulekar ‘22

Treasurer – Abbigale Shi ‘24

Communications Chair:– Jeonghoon Choi ‘22

Events Chair – Prinjali Kalyan ‘23

Public Relations Chair – Emily Oros ‘22

Undergraduate Research Activities

Fellows from the Distinguished Summer Research Fellowship program (DSRF) spend the summer engaged in a transformative research experience under the guidance of a faculty member. The program provides students with $10,000 per summer to cover housing, living expenses, and research expenses such as supplies, books, and related travel. Fellows must work full time in the lab of an engineering faculty member for at least 10 weeks.

The College of Engineering Supplemental Undergraduate Research Funds (SURF) program encourages faculty to involve undergraduates in their research programs during the academic year by providing matching funds for undergraduate students who are working on faculty-sponsored research. Requests for SURF funds are made by individual students when they have found positions in faculty labs.

The Undergraduate Research Opportunities Program (UROP) is a University-wide academic program which promotes participation by Boston University undergraduates in facultymentored research across all disciplines and throughout the calendar year.

DSRF Summer 2022

Armaan Vasowalla

Danielle Nadira

Do Hyun Park

Farida Korna

Gabriela Berniac

Hadassah Flagg

Johnathan Muhvich

Rashid Kolaghassi

Sarah Sheng

Taylor Ly

William Krska

Yiwen Zhang

DSRF Summer 2021

Alexandra Pineiro

Anushka Rathi

Artemis Margaronis

Brian Zhou

Emma Hartman

George Katsarakes

Isabelle Goode

Keira Donnelly

Riya Sen

SURF Summer 2021

Alexandra Van Waes

Aurelia Leona

Emily Martin

Gabriela Berniac

George Katsarakes

Jodee Frias

Joel Herbert

Julia Hua

Kate Lee

Matthew Collins

Nisrine Rahmaoui

Rana Hussein

Robert Bing

Ruiying Zhu

Soumaya Fayie

Zenia Valdiviezo

SURF Fall 2021

Alexandra Dolynuk

Alexandra Van Waes

Artemis Margaronis

Brian Zhou

Casey Goodwin

Emily Martin

Emma Hartman

Felicia Pinto

Fetsum Tadesse

George Katsarakes

Julia Hua

Juncheng Zhang

Ksenija Tasich

Layth Amra

May Aon

Nicole Leonard

Olivia Lewallen

Robert Bing

Soumaya Fayie

Zenia Valdiviezo

SURF Spring 2022

Artemis Margaronis

Aurelia Leona

Brandon Kao

Brian Zhou

Dayna Francis

Emilia Schimmelpfennig

Emily Martin

Emma Hartman

Fetsum Tadesse

George Katsarakes

Iris Vinal

Jenny Deng

Julia Hua

Juncheng Zhang

Kate Lee

Layth Amra

May Aon

Nicole Leonard

Nisrine Rahmaoui

Ruiying Zhu

Sidney Matta

Soumaya Fayie

Yuhan Li

Zenia Valdiviezo

UROP Fall 2021

Dhanvil Nanshah

Zachary Silfen

UROP Spring 2022

Artemis Margaronis

Brian Zhou

Chloe Grubb

Dea Turashvili

Emily Hill

Emre Karabay

Eren Ergene

Felicia Pinto

Gabriela Alba

Isabelle Goode

Jenny Deng

Mackenzie Obenreder

Madelyn Keller

Megan Lee

Melissa Gillis

Nicole Ostrovsky

Owen Kelly

Perry Katsarakes

Riya Sen

Taylor Ly

Zachary Silfen

UROP Summer 2021

Alec Perliss

Alexia Kaloudis

Daniel Jiang

Dogancan Kuyel

Grant Winkey

May Aon

Nicholas Mauro

Nicole Ostrovsky

Prakruti Dholiya

Rohin Bajaj

Siyuan Li

The Senior Design Project

A major strong point of our undergraduate program continues to be the Senior Design Project.

The Senior Design Project Experience

Every BME senior is required to develop a project proposal with an individual faculty member, local area scientific mentor, or even a bioengineering corporate technical advisor (with a BME faculty co-supervisor). The project is then carried out with the guidance of the student’s technical advisor. This brings together elements of engineering science and engineering design. In coordination with the technical work, this course includes experience in planning, establishing priorities and formal training in technical communication including proposal, abstract, progress reports and oral and written presentations of the final work. In conjunction

2022 Project Presentations

Neuroengineering

40 Hz Light Enhancement Study

Noah Abrha, Anton Homenuik, Eden Gideon, Jed Lartey, Medua Nwokolo

Development of Behavioral Task to Study Motor Control in Mice

Antoine Baize, Rachel Ferrigno, Sydney Holder, Zenia Valdiviezo

Optimization of Electroencephalography Reference Layer

Allan Garcia, Stefan Lütschg

Computer Automated Neuron Identification in Functional Microscopy for C. elegans

Jun Young Choi, Laura Mazuera

with the BME Department’s Visiting Committee, we have additional lectures from our industry partners to expose the students to elements of entrepreneurship, business plans, intellectual property, marketing, and clinical regulatory issues. The project continues over the full academic year and culminates in a Senior Design Project Conference that is attended by students, faculty, and representatives from BME industry, hospitals and other academic institutions. A record of the project presentations is followed by a listing of participating companies.

A Classifier for Predicting Depth of Anesthesia Using Multimodal Cortical Recordings

Vian Ambar Agustono, Elisa Cordeiro Lopes

A Cloud-Based Framework for Organizing and Analyzing fNIRS Datasets

Christian Arthur, Jeonghoon Choi, Jiazhen Liu, Juncheng Zhang

Investigating the Bioenergetic and Biophysical Effect of Ultrasound on Neural Mitochondrial Activity

John Rim, Rockwell Tang

NinjaNIRS 2022 Backpack System

Robert Bing, Benjamin Lissner, Juan Luis Ugarte Nunez

The Senior Design Project Devices

Developing an ECG Sensor and Smartphone Application to Monitor the Cardiac Health of Remote Patients

Rachael Chiao, Brian Jung, Jaspreet Momi, Dasha Veraksa

Multispectral 2D Imaging for Oxygen Saturation in Tumor Detection

Chengxi Fan, Yining Guo, Ziwen Xie

A Non-Invasive and Massively Parallel Imaging Device for Longitudinal Monitoring of Infection Progression in Fruit Flies

Beminet Desalegn, Joshua Monroy, Pablo Saucedo, Fetsum Tadesse

Improving the Sensitivity and Automating the Basilar Membrane Probe

Andrew Gross, Jose Miguel Sevilla, Jasper Zeng

NEPHRO: Novel Evaluative Probe for Hydration Real-Time Observation

Kylee Anders, Sabrina Franco, Jodee Frias, Olivia Claire Rose

Biomechanics

Novel Method for Strain Transfer Research on Murine Flexor Tendons at Cellular Level

Gabriela Alba, Anushka Murti, Chi Chiu Victor Wong

The Effect of Inflammatory Phase in Mechanobiological Modeling on Bone Fracture Healing

Zhuojian (Jamie) Jiang, Zakarey Sharif, Hanyu (Wendy) Wang

Rotator Cuff Tendon Surface Strain during Glenohumeral Motion: A Cadaveric Model to Assess the Effects of Mechanical Load and Joint Position

Andrew Miao, Zhongkun Xue

A System for Imaging Precision Cut Lung Slices

Keira Donnelly, Landon Kushimi, Reyn Tyler Saoit

Investigating the Density of Cetacean Middle Ear Bone

Viet Nguyen, Gautham Salgam, Danial Shafi

Nanoscience & Synthetic Biology

Miniaturized Microfluidic Device for High Throughput Production of Lipid Nanoparticles

Shirin Bakre, Genevieve Dowd, Liam Murray, Michael Sisk

Novel Nanoemulsions for Intra-ocular Delivery of Mitoprotective Drugs

Matthew Reynolds-Tejeda, Cedric Salame

Novel Design of Polymeric Nanoparticles for Targeted Drug Delivery to Glial Cells

Simrita Dhulekar, Elizabeth Hanchar, Alexandra Piñeiro, Rosangel Ramos Espinoza

Designing, Modeling, and Constructing Coherence Detection Synthetic Gene Circuits Based on Protein Oligomerization

Hannah Collins, Delaney Dow, Emily Hill, Blaire Smith

Apps & Diagnostics

Development of Affordable Kidney Disease Diagnostic Device for Use in Low Resource Areas

Lujain Khusheim, Ashley McFarlane, Ethan Strauther, Zakiah Tcheifa

Assessing Interstitial Fibrosis and Tubular Atrophy (IFTA) Using Minimally-Invasive Elastic Scattering Spectroscopy as an Indicator of Kidney Health

Giulia Boccardo, Ji Young Chung, Meghan Howard. Emily Oros

Effect of Digital Intervention on Social and Verbal Skills in Individuals with Autism Spectrum Disorder

Matthew Collins, Nathaniel Heitmann-Bastoni, James Maher

Digital Biopsy for Glomerular Ultrastructural Measurement in TEM Images

Connor Kim, Aksel Laudon, Grace Qian, Zhaoze Wang (ECE), Jackson Ye INTERDISCIPLINARY

The Senior Design Project

Digital & Predictive Medicine

Designing Novel Inhibitors of SARS-CoV-2 Viral Spike Protein Function by Targeting the Substrate Binding Domain of Chaperone Protein GRP78

Jonathan R. Hutton, Maria Lazou

Classifying and Modeling of Selective and Common Actives and Inactives Against GSK3⍺ and GSK3β

Joseph Bosco, Julia Roy

Computational Model of Tensional Homeostasis of Focal Adhesions at Subcellular Level

Selina Qin, Jiaming Zhang

Quantitative, Data-Driven Systems Analysis and Modeling to Improve Access to Healthcare Among Native American Communities in Rosebud, SD

Cecile Meier-Scherling, Taylor Schissel

Designing Novel Disruptors of SARS-CoV-2 Viral Spike Protein Function by Targeting the Nucleotide Binding Site of Chaperone Protein GRP78

Ximeng Fu, Huiyi Xiong

Cell & Tissue Engineering

Development of a Burst Pressure/Leak Testing System for Surgical Adhesives

Tyler Alstede, Connor Burke, Zachary Silfen, Kevin Wu

Developing Placenta-on-a-Chip Model to Test Drug Transfer at the Maternal-Fetal Interface

Mackenzie Obenreder, Christianna Roggeveen

Microfluidic Pump Optimizes Sample Transport In Integrated Bioreactor

Cassidy Balboa, Austin Cozzone, Kian Patton

Breaking Barriers in Bioprinting

Thang Le, Tiffany Lukmantara

A Long-lived Organ-on-chip Model of the Human Vasculature

Tyler Crawford, Krishna Kotak, Vien Tran

Projects Previously Presented

Development of a Dynamic Cushioning System with Continuous Piezoresistive Sensor Feedback for Pressure Injury Prevention and Treatment

Harin Lee, Irving Li (ME), Jessica Man (ME), Dhvanil Nanshah, Cooper Shifrin INTERDISCIPLINARY

Attachable Intraoral Camera for Dental Handpieces

Isabelle Goode, Megan Lee, Avani Sheth, Rishi Vaidya

Improving Management, Detection, and Treatment of Iron-Deficiency Anemia With Rapid, Portable, and Affordable

Next-Generation Point-of-Care Diagnostic Technology

Andrew Chan, Parth Jalihal, Sahil Mohanty, Rohun Yarala

Characterization of a Subcutaneous Bleb model

Jordan Barker, Thomas Settelmayer

Perfect Pessary

Lauren Caruso, Tiana Jazirian, Hayden Myers

Implantable Microdevice for Drug Efficacy Testing in Tumors

Samantha Downing, Rebecca Janes, Maria Merhej

Microneedle Blood Draw Device for Point-of-Care Anemia Diagnostic Test

Garrett Greaves, Safin Rouf, William Swift

The Senior Design Project

Participating Companies

PARTICIPATING COMPANIES:

3M

Accenture Life Sciences

Advanced Instruments, Inc.

Advanced Silicon Group

Ajax Biomedica

AltraBio

Altran

Applied Medical Resources

ArQule, Inc.

Atrium Medical

Avedro, Inc.

Banyan Life Sciences LLC

BD Advanced Diabetes Care

BD Medical

Beta Bionics

Beth Israel Deaconess Medical Center

Biotronik

BioTrove, Inc.

Bioventus LLC

Bitome

Boston Engineering

Boston Medical Center, Dept. of Anesthesiology

Boston Medical Center, Dept. of Clinical Engineering

Boston Medical Center, Dept. of Orthopedic Surgery

Boston Scientific

Boston University School of Management

Boston University School of Medicine

Boston University School of Medicine, Dept. of Pharmacology

Boston University School of Public Health

Boston University, Dept. of Athletic Training and Physical Therapy

Boston University, Dept. of Biochemistry

Boston University, Dept. of Biology

Boston University, Dept. of Mechanical Engineering

Boston University, Dept. of Physiological and Brain Sciences

Boston University, Dept. of Speech, Language and Hearing Sciences

Brandeis University

Brigham and Women’s Hospital

Bright Cloud International Corp

Broad Institute

Bruker Daltonics

CAE Healthcare

CBS Local

Center for Global Health and Development

Children’s Hospital Boston

CIMIT

CKD Associates

Clark & Elbing LLP

Cleveland Clinic

Codman Neuro, Johnson & Johnson

Colorado Nepal Alliance, Dept. of Veterans Affairs

Columbia University, College of Physicians and Surgeons

Comprehensive Health Management Inc.

ConforMIS, Inc.

Consult and Design

Covidien

CSA Medical

Cynosure

Davison

Davol - C.R. Bard, Inc.

Decision Resources

DEKA Research and Development Corporation

DePuy Spine, Inc.

DocBox, Inc.

Draeger Medical Systems, Inc.

Draper

Eastman Kodak Company

Eaton-Peabody Laboratory

Elm Electrical & Automation

EndoCore

Enumeral Biomedical Holdings, Inc.

Essex Orthopedics & Optima Sports Medicine

Fellers Snider et al.

Ferrotec Corporation

Fluidform

Foundation Medicine

Fractal Therapeutics

Fraunhofer USA-CMI

GE Healthcare

Gems Sensors

Genzyme Corporation

GlobalData Healthcare

Goodyear-Veyance Technologies, Inc.

Grant Street Group

Harvard Business School

Harvard Medical School

Harvard University

Harvard-MIT Division of Health Sciences and Technology

HeartWare, Inc.

Higher Order Technologies, LLC

Hologic

Hypertherm

Iandiorio Teska & Coleman

IDEXX Laboratories

Image Stream Medical

ImagiRation

Instrumentation Labs, Inc.

Integra LifeSciences

Ironwood Pharmaceuticals

iWorx Systems, Inc.

Jana Care Inc.

Janssen Pharmaceutical, Johnson & Johnson

JH Technologies

Johnson & Johnson

Lahey Hospital and Medical Center

Legionarius

Lux Research

Mankato National Instruments

Massachusetts Eye and Ear Infirmary

Massachusetts General Hospital

Massachusetts Institute of Technology

Medtronic, Inc.

METI

Minnesota State University

MIT/Koch Institute

Motility Biomedical, Inc.

nanoView Diagnostics , Inc.

Navinet

Neuroptix Corporation

New Health Sciences

Novartis Institutes for BioMedical Research

NuOrtho Surgical, Inc.

Olympus Surgical Technologies America

Optasia Medical, Inc.

Oregon Health & Science University

O’Shea Getz PC

Parexel

Perceptive Informatics PerkinElmer

Pfizer Biotherapeutics

Philips Healthcare

Philips Ultrasound

Praxis Advisors LLC

Pulmatrix, Inc.

Raytheon

Regeneron Pharmaceuticals

Respiratory Motion, Inc.

Rtangent

Sanofi

Sapient

Schepens Eye Research Institute

Schneider Electric

Shire Pharmaceuticals

Solace Therapeutics, Inc.

SoundMedicine

SQZ Biotechnologies

St. Jude Medical

Synthera Health

Takeda

Teleflex Medical

Ten15Ventures

Toxikon Corporation

Tufts University

UMASS

Universidad de Valencia

University of Texas at Austin

University of Wisconsin-Madison

US Army Institute of Environmental Medicine

USA Research Institute of Environmental Medicine

VA Boston Healthcare System

Vantage Management Group Verbal Care

Vertex Pharmaceuticals

Veterans Administration

Visus Technologies

Worcester Polytechnic Institute

Wyss Institute for Biologically Inspired

Engineering

Xcellerex

Youpling Corp.

Boston University Department of Biomedical Engineering

Annual Report 2021-2022

© 2022, Boston University

This report provides a description of the instructional and research activities of the Department of Biomedical Engineering at Boston University during the 2021-2022 academic year.

Boston University’s policies provide for equal opportunity and affirmative action in employment and admission to all programs in the university.

For more information or to download this report as a PDF, please visit our website at: bu.edu/bme

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