ESPCA by nação terra criativa

Dear SĂŁo Paulo School of Advanced Science on Vaccines participant, Welcome! Thank you for joining us in Santos. We are pleased to offer an international course in Brazil to train students, postdoctoral fellows, and early career individuals who are engaged in vaccine development. We are privileged to benefit from the participation of lecturers who are global leaders in vaccinology and immunology. Many lecturers will stay for at least a few days; we encourage you to interact with them, both during and outside of their formal lectures. While we are delighted to be joined by such a distinguished faculty, much of the richness of the course comes from you, the participants. All participants will have the opportunity to present ongoing work in posters, and most of you will also have the opportunity to present your work in a 10 minutes talk. We hope this will stimulate new collaborations. Many future successes in vaccine development will depend on your knowledge and commitment. We have selected a group of participants that reflects a wide range of specialties and geographic origins, and we look forward to many rich and stimulating discussions over the course period. Santos is a lively city, and we encourage you to go and explore its many interesting features.

Dr. Irene S. Soares Dr. Silvia B. Boscardin Dr. Daniel Y. Bargieri Dr. Helder Nakaya Dr. Eduardo Silveira Dr. Ricardo Gazzinelli 3

Index

University of SĂŁo Paulo

Organizing Committee

Course Expenses

Programme Summary

Importance of the Event

High-Profile Professors

Key dates

High-Profile Professors

Application and costs

Maps

Program

Professors

Organizers

Participants

UNIVERSITY OF SÃO PAULO The University of São Paulo (USP) is the largest institution dedicated to higher education and research in Brazil. It is a public university maintained by the State of São Paulo. Created in 1934, USP is one of the most important institutions of higher learning in Latin America. USP’s undergraduate program consists of 249 majors in all fields of knowledge, distributed across 42 institutes and faculties, with more than 58,000 students. Graduate-level teaching comprises 239 MSc and PhD programs with 35,000 students. USP’s campus expands across the cities of São Paulo, Ribeirão Preto, Piracicaba, São Carlos, Santos, Pirassununga, Bauru, and Lorena. Additional USP museums and research centers are located outside these locations, in various municipalities in the State of São Paulo. The School of Pharmaceutical Sciences and the Institute of Biomedical Sciences host many research groups in vaccinology and immunology. They are both located in the main campus of USP on the west side of the city of São Paulo (neighborhood of Butantã).

ORGANIZING COMMITTEE Dr. Irene S. Soares School of Pharmaceutical Sciences University of São Paulo

Dr. Silvia S. Boscardin Institute of Biomedical Sciences University of São Paulo

Dr. Daniel Y. Bargieri Institute of Biomedical Sciences University of São Paulo

Dr. Helder Nakaya School of Pharmaceutical Sciences University of São Paulo

Dr. Eduardo Silveira School of Pharmaceutical Sciences University of São Paulo

Dr. Ricardo Gazzinelli Oswaldo Cruz Foundation Rene Rachou Institute

COURSE EXPENSES Our main course sponsor, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), is providing generous Travel Award Fellowships to all participants. The following course expenses are covered by this support:

Transportation: Round-trip economy-class airfare to São Paulo, Brazil, for international participants and Brazilian participants traveling more than 400 km. Transfer to the course venue.

Accommodations: A hotel room (to be shared with other participants of the same gender) for the duration of the course at Mendes Plaza Hotel, as well as daily breakfast, lunch and dinner, and Internet access. Refreshments during course breaks.

The Travel Award Scholarships do NOT include the following, which are the responsibility of the participant: Visa fees; Extra nights at the hotel before/after the course; Personal expenses.

Boarding Pass If your travel is supported by FAPESP, you are required to keep your original boarding pass and bring it with you at the opening day of the course (November 22). We expect to help you with the online check in for your return flight, so we can save a PDF copy of your boarding pass. If this not possible, we ask you to send your boarding passes by e-mail to: fapesp.vaccines@gmail.com

The course is also sponsored by generous partners: BD Biosciences offers the opening cocktail and a prize at the end of the course. University of São Paulo and Sinapse offer coffee breaks. The Brazilian Society of Immunology (SBI) and Eppendorf offer room structure. The National Institute of Technology and Science on Vaccines (INCTV) offers the poster structure.

Local Currency Brazil’s currency is called the Real (meaning both “royal” and “real”); the plural is Reais. The symbol is R$ and the currency code is BRL. A Real is comprised of 100 “centavos.” The exchange rate as of October 30, 2018 was BRL 3.70 per US Dollar. If you have a credit card, call your credit card company to let them know you’ll be in Brazil; while credit cards are accepted widely in cities, it will be convenient for you to have modest quantities of cash for personal expenses and purchases. If you have an ATM card, you can withdraw cash from the automatic tellers at the airport upon arrival, and throughout the city. The exchange rate you get by withdrawing from a cash machine will likely be better than that at an airport currency exchange. Avoid withdrawing cash at night for safety reasons. When possible, withdraw money at indoor shopping centers, convenience stores, etc. Travelers’ checks are not widely accepted in Brazil. 8

Phones Pre-paid mobile phones are widely used in Brazil. Leading operators in Brazil include TIM (www.tim. com.br), Claro (www. claro.com.br), Oi (www.oi.com.br), and Vivo (www.vivo.com.br). If you have an unlocked GSM mobile phone from your existing operator, you will be able to purchase a SIM card (the small chip located within GSM phones) with pre-paid minutes on it from a local mobile phone operator in Brazil and simply swap out the SIM card in your existing phone. Brazil’s country code is “55.” The local area code of São Paulo is 11. The local area code of Santos is 13. When dialing from one city to another within Brazil, dial 0+21+city code+phone number (eight or nine digits). To dial internationally, dial: 00 + an exit code (depends on which network you are using: 0015 – Vivo, 0021 – Claro, 0031 – Oi, 0041 – Tim) + country code + phone number.

Local transportation To travel to other places on your own time you can use taxis or buses. The hotel is located at a very lively region in Santos, near the beach (walking distance).

Course Venue The course will meet in the RUBI Auditorium at the Mendes Plaza Hotel, except on the first day, when we will meet at the CRISTAL Auditorium.

Hotel Information Mendes Plaza Hotel Located in the heart of the Gonzaga (the most traditional neighborhood of Santos) and one block from the beach, the Mendes Plaza Hotel offers all the comfort and convenience you deserve. It comprises two Towers (Plaza and Panorama) and stands out for the excellent infrastructure offered to welcome guests. In addition to the accommodations, guests can take advantage of the sophisticated “The Garden” Restaurant, which offers the best of international cuisine. The hotel also offers guests broad access to the internet, providing free high-speed Wi-Fi in all areas. Finally, the Mendes Plaza Hotel is attached to Miramar Shopping, one of Santos’ main shopping centers with more than 100 stores and a food court. It is 4.5 km away from Santos Bus Terminal, 4.6 km away from the Cruise Terminal and 1 hour from the city of São Paulo. Tel: +55 13 3208-6400

Emergencies To call the police, ambulance or fire department in Brazil, dial 190, 192, and 193, respectively. In case of any emergency please contact: Irene Soares (English/Portuguese): 55-11-999331657 Silvia Boscardin (English/Portuguese): 55-11-963430277 Daniel Bargieri (English/French/Portuguese): 55-11-941305792 Helder Nakaya (English/Portuguese): 55-11-941992004 Eduardo Silveira (English/Portuguese): 55-11-964841980

PROGRAMME SUMMARY The SĂŁo Paulo Advanced School on Vaccines aims to provide participants with a critical and comprehensive view of the state of the art in vaccine research.

IMPORTANCE OF THE EVENT Vaccines are arguably the most important tools for global health. Vaccination reduces disability and death, and saves billions in public health costs by preventing disease. However, the discovery of new vaccines has been very limited. The challenges for the discovery and development of new vaccines will be addressed at the Sao Paulo Advanced School, where a multidisciplinary group of worldrenowned scientists will be present. The event will bring together experts from Brazil, United States, Europe, and Asia, along with students from the entire world.

HIGH-PROFILE PROFESSORS The program of lectures given by internationally renowned researchers includes research themes for the development of vaccines against pathogens of great importance, such as those causing malaria, AIDS, dengue, zika, and chikungunya

KEY DATES Application period: April 1st to June 10th, 2018 Selection process: June-July, 2018 Application results: August, 2018

APPLICATION AND COSTS We will provide FULL coverage of costs and expenses related to the course (travel, meals, accommodation, etc). The Sao Paulo Advanced School on Vaccines will select 80 PhD students, post-docs and independent researchers, of which 40 will be international candidates. Application period is over. We have over 200 applicants from 37 different countries!

PROGRAM DAY 1 - 11/22/2018 - THURSDAY 9:00 - 9:20

9:20 -10:10

Welcome remarks Dr. Irene S. Soares and Dr. Ricardo Gazzinelli Opening lecture - Chair: Dr. Daniel Bargieri The history of vaccination and global impact Dr. Oscar Bruna-Romero (Federal University of Santa Catarina, Brazil)

10:10 - 10:30

Coffee Break

10:30 - 10:40

Definition of the groups for project discussion

10:40 - 11:30

Plenary lecture A - Chair: Dr. Helder Nakaya The WHO priorities and challenges Dr. Ricardo Palacios - Butantan Institute – Brazil

11:30 - 12:20

Plenary lecture B - Chair: Dr. Helder Nakaya Novel mechanisms of host resistance to the malaria erythrocytic stages Dr. Ricardo Gazzinelli - University of São Paulo – Brazil

12:20 - 14:00 14:00 - 15:40

Lunch Chair: Dr. Silvia Boscardin ORAL PRESENTATIONS FROM STUDENTS (I)

15:40 - 16:00 16:00 - 18:30 19:00 - 23:00 16

Coffee Break Project discussion - Groups 1-8 Welcome cocktail party

DAY 2 - 11/23/2018 - FRIDAY 9:00 - 10:40

Chair: Dr. Eduardo Silveira ORAL PRESENTATIONS FROM STUDENTS (II)

10:40 – 11:00

Break

11:00 – 11:40

Lecture 1 - Chair: Dr. Oscar Bruna Romero Antigen presentation and the Dendritic Cell Dr. Silvia Boscardin (University of São Paulo, Brazil)

11:40 – 12:30

Lecture 2 – Chair: Oscar Bruna Romero Heterologous (non-specific) effects of vaccines Dr. Nigel Curtis (University of Melbourne – Australia)

12:30 - 13:30

Lunch

13:30 - 15:30

Project discussion - Groups 1-8

15:30 - 18:30

Mini symposia - Arboviruses - Chair: Dr. Ricardo Gazzinelli Dr. Jean Pierre Schartzmann Peron (University of São Paulo, Brazil) Coffee Break Dr. Esper G. Kallas (University of São Paulo, Brazil) Dr. Rafael Larocca (Harvard Medical School, USA)

DAY 3 - 11/24/2018 - SATURDAY 9:00 - 10:30

Chair: Dr. Daniela Santoro Rosa ORAL PRESENTATIONS FROM STUDENTS (III)

10:30 - 12:00

Project discussion - Groups 1-8

12:00 - 13:30

Lunch

13:30 - 14:20

Lecture 3 - Chair: Dr. Karina Bortoluci B-cell and the germinal center Dr. Gabriel Victora (The Rockefeller University, USA)

14:20 - 15:10

Lecture 4 - Chair: Dr. Karina Bortoluci Reverse vaccinology Dr. Rino Rappuoli (GlaxoSmithKline, Italy)

15:10 - 16:00

Lecture 5 - Chair: Dr. Karina Bortoluci Neutralizing Antibodies Dr. Ésper G. Kallas (University of São Paulo, Brazil)

16:00 - 16:20

Coffee Break

16:20 - 18:20

Plenary lectures D and E - Chair: Dr. Ésper Kallas Dr. Gabriel Victora (The Rockefeller University, USA) Dr. Rino Rappuoli (GlaxoSmithKline, Italy)

DAY 4 - 11/25/2018 - SUNDAY 8:20 - 10:00

Chair: Dr. José Ronnie Vasconcelos ORAL PRESENTATIONS FROM STUDENTS (IV)

10:00 - 10:20 10:20 - 12:00

Coffee Break Lecture 6 - Chair: Dr. Eduardo Silveira Innate immunity Lecture 6A: Dr. Karina Bortoluci (Federal University of Sao Paulo, Brazil) Lecture 6B: Dr. Dario Zamboni (University of Sao Paulo, Brazil)

12:00 - 13:00

Lunch

13:00 - 14:40

Lecture 7 - Chair: Dr. Irene Soares Cellular immunity Lecture 7A: Dr. Maria Bellio (Federal University of Rio de Janeiro, Brazil) Lecture 7B: Dr. José Ronnie Vasconcelos (Federal University of Sao Paulo, Brazil)

14:40 - 15:30

Lecture 8 - Chair: Dr. Maria Bellio Genetics and virulence Dr. Santuza Teixeira (Federal University of Minas Gerais, Brazil)

15:30

SOCIAL EVENT

DAY 5 - 11/26/2018 - MONDAY

08:00

Shuttle leaves to University of São Paulo

10:00 - 12:00

Visit the Institute of Biomedical Sciences – USP

12:00 - 13:30

Lunch

13:30 - 15:30

Visit the School of Pharmaceutical Sciences – USP

15:30 - 16:00

Presentation from FAPESP - Dr. Hernan Chaimovich

16:00

Shuttle leaves to Hotel

DAY 6 - 11/27/2018 - TUESDAY 9:00 - 10:40

10:40 - 12:00 12:00 - 13:30 13:30 - 14:20

Chair: Dr. Arturo Reyes Sandoval ORAL PRESENTATIONS FROM STUDENTS (V) Project discussion - Groups 1-8 Lunch Lecture 9 - Chair: Dr. Daniela Santoro Rosa Antigen discovery Dr. Edécio Cunha Neto (University of São Paulo, Brazil)

14:20 - 15:10

Lecture 10 - Chair: Dr. Daniela Santoro Rosa Antigen expression systems Dr. Takafumi Tsuboi (Ehime University, Japan)

15:10 - 15:30 15:30 - 16:20

Coffee Break Lecture 11 - Chair: Dr. Silvia Boscardin Heterologous prime-boost vaccination Dr. Arturo Reyes Sandoval (Oxford University, UK)

16:20 - 18:00

Lecture 12 - Chair: Dr. Silvia Boscardin Mucosal immunology and vaccines Dr. Denise Moraes da Fonseca (University of São Paulo, Brazil) Dr. Luís Carlos de Souza Ferreira (University of São Paulo, Brazil)

18:00 - 18:50

Lecture BD FACSymphony

DAY 7 - 11/28/2018 - WEDNESDAY 9:00 - 10:40

Chair: Dr. Helder Nakaya ORAL PRESENTATIONS FROM STUDENTS (VI)

10:40 - 12:30

Project discussion - Groups 1-8

12:30 - 14:00

Lunch

14:00 - 14:50

Lecture 13 - Chair: Dr. Irene Soares Designing Phases 1 and 2 Clinical Trials Dr. Andrew Simpson (Orygen)

14:50 - 15:40

Plenary lecture F - Chair: Dr. Daniel Bargieri Dr. Nigel Curtis (University of Melbourne â&#x20AC;&#x201C; Australia)

15:40 - 16:00

Coffee Break

16:00 - 19:00

Plenary lectures G and H - Chair: Dr. Daniel Bargieri Dr. Takafumi Tsuboi (Ehime University, Japan) Dr. Arturo Reyes Sandoval (Oxford University, UK)

DAY 8 - 11/29/2018 - THURSDAY 9:00 - 10:40

Chair: Dr. Fabio Costa ORAL PRESENTATIONS FROM STUDENTS (VII)

10:40 - 12:30

Project discussion - Groups 1-8

12:30 - 14:00

Lunch

14:00 - 15:40

Mini symposia: Translational vaccinology - Chair: Dr. Daniela S. Rosa Dr. Andrew Simpson (Orygen) Dr. Ana Paula Salles Fernandes (Federal University of Minas Gerais, Brazil)

15:40 - 16:00 16:00 - 18:10

Coffee Break Mini symposia: Cancer immunology and vaccines - Chair: Dr. Silvia Boscardin Dr. Gustavo Amarante-Mendes (University of São Paulo, Brazil) Dr. Stephen Schoenberger (La Jolla Institute for Allergy and Immunology, USA) Dr. José Alexandre M. Barbuto (University of São Paulo, Brazil)

18:10 - 20:00

POSTER SESSION I

DAY 9 - 11/30/2018 - FRIDAY 8:20 - 9:40

Chair: Dr. Ricardo Gazzinelli ORAL PRESENTATIONS FROM STUDENTS (VIII)

9:40 - 10:30

Plenary lecture I - Chair: Dr. Ricardo Gazzinelli Dr. Fabio Costa (University of Campinas, Brazil)

10:30 - 10:50

Coffee Break

10:50 - 12:30

Plenary lectures J and K - Chair: Dr. Gustavo Amarante-Mendes Dr. Stephen Schoenberger (La Jolla Institute for Allergy and Immunology, USA) Dr. José Alexandre M. Barbuto (University of São Paulo, Brazil)

12:30 - 14:00

Lunch

14:00 - 15:20

Final project presentation Groups 1 and 2

15:20 - 15:40

Coffee Break

15:40 - 17:00

Final project presentation Groups 3 and 4

17:00 - 19:00

POSTER SESSION II

DAY 10 - 12/01/2018 - SATURDAY 9:00 - 10:20

Final project presentation Groups 5 and 6

10:20 - 10:40

Coffee Break

10:40 - 12:00

Final project presentation Groups 7 and 8

12:00 - 14:00

Lunch

14:00 - 20:00

Free afternoon

20:00 - 23:00

Closing cocktail party

DAY 11 - 12/02/2018 - SUNDAY 9:30 - 10:30

Closing lecture - Chair: Dr. Irene Soares Vaccinology in the era of high-throughput biology Dr. Helder Nakaya (University of SĂŁo Paulo, Brazil)

10:30 - 11:00

Dr. Ricardo Gazzinelli - Presentation of the National Institute of Science and Technology in Vaccines

11:00 - 12:00

Final remarks Dr. Irene Soares and Dr. Ricardo Gazzinelli

12:00 - 13:00

Lunch

13:00 - 16:00

Shuttles leave to the airport 25

PROFESSORS

Rino Rappuoli Rino Rappuoli is Chief Scientist & Head of External Research and Development (R&D) at GlaxoSmithKline (GSK) Vaccines. He is known globally for his work in vaccines and immunology. He cofounded the field of cellular microbiology, a discipline combining cell biology and microbiology, and pioneered the genomic approach to vaccine development known as reverse vaccinology.

Takafumi Tsuboi Dr. Tsuboi has a Doctor of Medicine degree from the School of Medicine at the Ehime University where in 1986 he obtained a Ph.D. in parasitology. In 1997 he became Associate Professor at the Department of Parasitology of the Ehime University, and in 2003 he became Professor at the Cell-free Science and Technology Research Center at the same university. Since 2013 he is a Professor at the Division of Malaria Research and is the Director of the Proteo-Science Center, Ehime University, Japan. His laboratory uses cell-free protein expression technology to study malarial antigens.

Stephen Schoenberger Professor at La Jolla Institute for Allergy and Immunology and Co-Director of San Diego Center for Precision Immunotherapy. He is a translational cellular immunologist working on precision cancer immunotherapy through the development of personalized vaccines and cellular therapies.

Gabriel Victora Dr. Victora obtained Bachelor and Master of Music degrees from the Mannes College of Music. In 2006 he obtained a Master of Science in immunology at the University of Sao Paulo and in 2011 a Ph.D. in immunology at the New York University. He was a Whitehead Fellow at the Whitehead Institute for Biomedical Research from 2012 to 2016. Since 2016 he is an Assistant Professor at the Rockefeller University and head of the Laboratory of Lymphocyte Dynamics. In 2017 he was awarded the MacArthur Genius Grant. His laboratory studies how antibodies are formed. Arturo Reyes-Sandoval Dr. Arturo Reyes-Sandoval is an Associate Professor at the Nuffield Department of Medicine (University of Oxford) since 2015. His laboratory has been working on the vaccine development for neglected and emerging infectious diseases, such as Chagas disease, Dengue, Malaria (P. vivax), Zika and Chikungunya. For the last 3 cited diseases, vaccine formulations developed by his group have already entered in the clinical stage testing. Also, he contributed to the creation of the NDM-Mexico initiative to support collaborative work between research groups in Oxford with Mexican scientists. Nigel Curtis Prof Nigel Curtis is a clinician scientist who trained in the UK and Canada. He is now based in Australia where he is Head of Infectious Diseases at the Royal Children’s Hospital Melbourne and Professor of Paediatric Infectious Diseases at the University of Melbourne. He is also Leader of the Infectious Diseases & Microbiology Research Group at the Murdoch Children’s Research Institute. His research interests focus on the innate and cellular immune response to BCG vaccine, as well as the immunodiagnosis of childhood TB (or not TB). Prof Curtis leads a large randomised controlled trial of neonatal BCG vaccination to investigate the immunomodulatory heterologous (‘non-specific’) effects of this vaccine, including its ability to prevent infections, allergic disease and asthma.

Andrew Simpson Andrew Simpson earned his Ph.D. in 1980 at the National Institute for Medical Research (Mill HillLondon), in the Division of Parasitology and subsequently spent two years at the National Institutes of Health (USA). In 1990, Dr. Simpson moved to Brazil where he continued his research into schistosomiasis and other parasitic diseases while working at the Centro de Pesquisas René Rachou of the Fundação Oswaldo Cruz in Belo Horizonte. In 1995, he joined the Ludwig Institute for Cancer Research (LICR) in São Paulo where he extended his research interests into genomics, and led the FAPESP and national genome projects between 1997 and 2002. In 2002, Dr Simpson transferred to the Ludwig Institute’s office in New York and eventually became LICR Scientific Director in 2007. In 2012, Dr. Simpson left LICR and moved back to Brazil to take up the position of Scientific Director of the Brazilian startup biotechnology company Orygen. Orygen is currently being structured to develop, produce and commercialize therapeutic monoclonal antibodies and vaccines. Denise da Fonseca Dr. Fonseca has a Ph.D. in immunology in 2006 from the University of Sao Paulo. From 2012 to 2016 she was a postdoctoral fellow at the Laboratory of Parasitic Diseases of the National Institute of Health. Since 2016 she is a FAPESP Young Researcher at the Department of Immunology of the Institute of Biomedical Sciences, University of Sao Paulo. In 2016 she was awarded the prize L’Oréal-UNESCO For Women in Science. Her laboratory studies the interactions of mucosal immunity and the gut microbiota. Rafael Larocca Dr. Larocca joined Dr. Dan Barouch’s laboratory at the Center for Virology and Vaccine Research (Beth Israel Deaconess Medical Center - Harvard Medical School). Currently, he is an Instructor there and his projects aim to develop potential vaccine candidates to prevent viral infections, such as HIV and Zika. His research interests are focused on cellular and humoral immune response as well as in vaccines, viral vectors for vaccination (adenovirus), immunomodulatory pathways, innate immunity and T and B lymphocytes. 28

Esper Kallás Dr. Kallás graduated in Medicine in 1989. In 1996, he obtained a Master’s degree, and in 1999, a Ph.D. in Infectology from the Federal University of São Paulo. Since 2009, he is an Associate Professor at the University of São Paulo School of Medicine. He is also a Researcher at the Laboratory of Clinical Immunology and Allergy (LIM-60), where he carries out translational medicine projects, bringing basic science concepts to clinical applications, especially in infectious diseases. Edécio Cunha-Neto Dr. Cunha Neto completed his post-doctorate/visiting research internships at the Universities of Stanford (1991) and Harvard (2002), and at the Instituto Roche Milano Ricerche in Italy (1996). In 2001, he became an Associate Professor at the University of São Paulo School of Medicine. He is currently chief of the Laboratory of Clinical Immunology and Allergy (LIM60) and vice-coordinator of the Research Support Center of the Institute of Immunology Research (INCTiii). His laboratory focuses on translational research in the areas of cellular and molecular immunology of human diseases, with emphasis on the immunopathology of chronic Chagas’ heart disease and HIV-1 infection. Daniela Santoro Rosa Dr. Rosa obtained her Ph.D. in Microbiology, Immunology and Parasitology from the Federal University of São Paulo in 2006. Since 2010, she is a Professor at the Department of Microbiology, Immunology and Parasitology of the Federal University of São Paulo. Her laboratory is interested in the development and evaluation of new vaccine candidates for HIV, Zika and Chikungunya, and also studies the effect of sleep deprivation on immunity.

Luís Carlos Ferreira Dr. Ferreira is the current Director of the Biomedical Sciences Institute at University of São Paulo. As head of the Vaccine Development Laboratory, his research interests focus on the development of different vaccine strategies for dengue, dental caries, tumors induced by papilloma virus and diarrhea diseases caused by enteric bacteria. Gustavo Amarante-Mendes Dr. Gustavo P. Amarante-Mendes is the current vice-director of the Institute of Biomedical Sciences at the University of São Paulo and was the president of the Brazilian Society of Immunology (2016-2017). He worked as a Research Associate at the La Jolla Institute for Allergy and Immunology, and as visiting scientist at Trinity College Dublin and at Genentech. His laboratory studies cancer immunology and cell-death. Oscar Bruna-Romero Dr. Bruna-Romero obtained his PhD degree at the University of Navarra, Spain. He completed post-doctoral internships in Spain (ISCIII - Ministry of Health) in 1998 and USA (New York University) in 2001. He was a Visitant Researcher at FIOCRUZ, Brazil from 2001 to 2004, when joined Federal University of Minas Gerais, Brazil as an Assistant Professor. Currently, he is an Associate Professor at the Federal University of Santa Catarina with research interests focused on Immunology and Microbiology towards the development of recombinant vaccines (viral vectors) against infectious diseases. Santuza Teixeira Dr. Teixeira is Full Professor at the Federal University of Minas Gerais, member of the Brazillian INCT (CNPq) for Vaccine development, Coordenator of the Center of Vaccine Technology in Vaccines, Brazil and has been ranked as 1B Researcher at CNPq, Brazil. Her research interests focus on Molecular Parasitology and Parasite Genomics to evaluate gene expression, parasite-host interactions, genetic variability and DNA repair in Trypanosoma cruzi. 30

Maria Belio Dr. Bellio has a PhD degree in Biophysics at the Federal University of Rio de Janeiro, Brazil. She is Associate Professor and Head of Department of Immunology at the Federal University of Rio de Janeiro. Her research interests focus on Cellular Immunology aspects, such as antigen recognition by TCR, role of TLRs in the cytotoxic CD8+ T cell response against Trypanosomatides, MyD88-dependent signalling pathways in Th1 response, development of vaccines based on recombinant phages as vaccine vectors, B cell maturation, homeostasis of Treg cells and control mechanism for experimental colitis and ZIKVspecific immunity. Ana Paula Fernandes Dr. Fernandes has a PhD degree in Parasitology at the Federal University of Minas Gerais, Brazil in 1997. Currently, she is Full Professor at the Federal University of Minas Gerais and has been ranked as 1B Researcher at CNPq, Brazil. Her research interests focus on the development of diagnostics, molecular epidemiology, vaccine and treatment against infectious diseases as Leishmaniasis. Also, risk factors associated with hipercoagulation states have been investigated. Dario Zamboni Dr. Zamboni is an Associate Professor at the RibeirĂŁo Preto School of Medicine, University of SĂŁo Paulo (FMRP/USP) and an Affiliate Member of TWAS (The World Academy of Sciences - TWAS/UNESCO). The research carried out by Dr. Zamboni involves areas of Cell Biology, Microbiology and Immunology, with special emphasis on Pathogen-Host Cell Interaction and aspects of Microbial Pathogenesis and Innate Immunity.

Fabio Trindade Costa Dr. Costa is an Associate Professor at the State University of Campinas (UNICAMP) where he is also coordinator of international actions of the Institute of Biology and the postgraduate program in Genetics and Molecular Biology. He served as UNICAMP’s international relations adviser from 2010 to 2012. His lines of research involve immunopathological aspects of malaria and the development of new drugs and experimental vaccines. Karina Bortoluci Dr. Bortoluci holds a Ph.D. (2003) and post-doc (2005) in Immunology from the University of São Paulo. She is currently an Associate Professor in the Department of Biological Sciences at the Federal University of São Paulo (UNIFESP), and responsible for the Molecular Immunology Laboratory in the Center for Cellular and Molecular Therapy (CTC-Mol). The main focus of her research group is the study of the molecular pathways involved in the activation of inflamomasomes and their impact on the control of infections caused by Salmonella typhimurium, Trypanosoma cruzi and Zika virus. Ricardo Palácios Gomez Dr. Palácios Gomez is is currently Research and Clinical Development Manager of the Butantan Institute. He holds a medical degree from the National University of Colombia (1995) and a social sciences degree from the University of São Paulo (2016). He has also a PhD in Infectology from the Federal University of São Paulo (2006) and a specialization in Bioethics from the University of São Paulo (2012).

José Ronnie de Vasconcelos Dr. Carvalho de Vasconcelos has a PhD in Microbiology and Immunology from the Federal University of São Paulo (2004). He is currently Adjunct Professor in the Department of Biosciences of the Federal University of São Paulo (Campus Baixada Santista). His research lines focus on the development of DNA and recombinant adenovirus vaccines against Trypanosoma cruzi, the causative agent of Chagas Disease. Jean Pierre Schatzmann Peron Dr. Peron obtained his PhD degree at the University of São Paulo (2008). Currently, he is an Associate Professor at the University of São Paulo with research interests focused on the cellular and molecular mechanisms involved in the pathogenesis of microcephaly caused by Zika virus. José Alexandre Marzagão Barbuto Dr. Barbuto graduated in Medicine in 1981. In 1983, he obtained a Master’s degree in Microbiology and Immunology from the Federal University of São Paulo, and in 1988, a Ph.D. in Immunology from the University of São Paulo. Since 2007, he is an Associate Professor at the University of São Paulo. His research line focuses on cancer immunotherapy, studying mainly dendritic cells and their clinical applications.

ORGANIZERS Irene Soares Irene da Silva Soares is Assistant Professor at the Department of Clinical Analyses and Toxicology of School of Pharmaceutical Sciences. She works in the field of Protozoology of Parasites, specifically in human malaria. Dr. Soares’ team combines decades of experience of malaria research in the Amazon with internationally recognized expertise in the areas of epidemiology and immunology in order to generate know-how that can be translated in the development of an effective vaccine against malaria caused by Plasmodium vivax, the most prevalent species in Brazil. Ricardo Gazzinelli Ricardo Gazzinelli is Professor at the Federal University of Minas Gerais (UFMG), Senior Investigator at the René Rachou Institute from Oswaldo Cruz Foundation (Fiocruz), Professor at the University of Massachusetts Medical School (UMMS), and CNPq Researcher. He has done important contributions in the area of immunology of infectious diseases. In 2001, he was listed by the ISI Web of Knowledge among the Highly Cited Immunologists demonstrating his influential work in the area of immunology. He is the Director of the National Institute of Science and Technology in Vaccines/MCT, and has contributed for the development of vaccines against neglected diseases, which include Chagas disease, leishmaniasis, and malaria.

Daniel Bargieri Graduated in Biomedical Sciences in the Federal University of São Paulo (2004) and Ph.D. in Microbiology and Immunology, Federal University of São Paulo (2009). Did a post-doctoral training at the Institut Pasteur in Paris, France. He is currently assistant professor at the Dapertment of Parasitology, University of São Paulo. Has experience in immunology with emphasis on vaccine development, in molecular genetics of Plasmodium oriented for generation of recombinant parasites, and in the field of cell biology of Plasmodium. (Source: Lattes Curriculum)

Silvia Boscardin Dr. Silvia Beatriz Boscardin is an assistant professor at Department of Parasitology / Institute of Biomedical Sciences, University of SĂŁo Paulo (USP). She has experience in Parasitology and Immunology, with emphasis on the development of vaccination strategies against parasites and viruses. Present projects involve the use of a strategy to target proteins derived from pathogens (more specifically Plasmodium sp. and dengue virus) to dendritic cells (DCs) that are responsible for the activation of the adaptive immune response. Eduardo da Silveira Eduardo Lani Volpe da Silveira is an Assistant Professor at University of Sao Paulo, Brazil, in the School of Pharmaceutical Sciences. Dr. Silveira obtained Masters and PhD degrees in Immunology and had a 6-year postdoctoral period in the same field. His strong background in vaccine development has allowed him to investigate the development of protective immune responses against viral and parasitic infections. Dr. Silveira research is focused on B cell responses elicited by viral infections (Dengue, Zika, Chikungunya) or immunizations (Dengue, Influenza and Hepatitis B). Helder Nakaya Helder Nakaya is an assistant professor of University of Sao Paulo, Brazil and adjunct professor at Emory University, USA. He has a PhD in Molecular Biology with extensive training in Bioinformatics. He is an expert in Systems Vaccinology, an interdisciplinary field that combines systems-wide measurements, networks, and predictive modeling in the context of vaccines and infectious disease. Dr. Nakaya has developed systems biology approaches to understand and predict the mechanisms of vaccine induced-immunity for Yellow Fever, seasonal Influenza, Meningococcal, and Tularemia vaccines. His lab is focused on investigating the basis of infectious diseases using computational systems biology. 35

PARTICIPANTS Alphonse Ouedraogo [Burkina Faso] Dr. Ouédraogo has a Doctor of Medicine degree in 2002 from the School of Medicine at the University of Ouagadougou (Burkina Faso). In 2013, he obtained a Ph.D. in medical epidemiology from the University of Roma Sapienza (Italy). During his career, he has progressively gained more expertise in malaria epidemiology and clinical trials. He currently serves as the Head Scientist of the Development of New Drugs and Vaccines Laboratory for CNRFP. Amed Ouattara [United States] I am a Research Associate at the Center for Vaccine Development and Global Health, University of Maryland, Baltimore. I use a diversity-covering approach that incorporates polymorphisms from various malaria parasite alleles into the design of a multivalent vaccine to address the issue of antigen diversity. The approach prioritize malaria vaccine antigens and, importantly, variants of these antigens based on a systematic evaluation of their worldwide genetic diversity and haplotype prevalences. Angela Choi [United States] Angela is a PhD candidate at Icahn School of Medicine at Mount Sinai in Dr. Adolfo García -Sastre’s laboratory. Her research focuses on how preexisting immunity to influenza modulates virus-host interactions in the antigenexperienced host. Specifically, she is trying to dissect the different aspects of both the innate and adaptive branch of the host immune response to vaccination and repeated influenza virus infections, and how these parameters contribute to long-lasting protection. Aroon Chande [United States] Aroon Chande is a Ph.D. student in the Jordan Lab at Georgia Institute of Technology and a Bioinformatics Scientist with the Applied Bioinformatics Laboratory. His Ph.D. focuses on recently admixed populations in Colombia and ancestry-specific health disparities. His work at the Applied Bioinformatics Laboratory supports public health initiatives across the United States through software development, workforce development training, and bioinformatics research. 36

Beatriz Meza [México] Beatriz Meza-Márquez. I am a doctoral student in the Center for Biological Research of the Northwest (CIBNOR, México). My current research is in the final stages of the development of a multiantigenic, multistage and multiepitope vaccine against Helicobacter pylori. Camille L. Novis [Unites States] Dr. Novis obtained a Bachelor’s degree from the Universidade Federal Fluminense, Brazil. During her undergraduate studies she was a CNPq fellow at FIOCRUZ. In 2015, she obtained her Ph.D. in Immunology & Microbiology from the University of Utah, USA. As a Ph.D. candidate, she described HIV latency-reversal compounds. Currently, as a postdoctoral fellow, Dr. Novis studies the effect of epigenetics in Tfh cell differentiation and its contribution to the improvement of humoral immunity. Carolina M. Andrade [Germany] Young scientist with a strong knowledge of host-pathogen interactions, mainly in Plasmodium parasites. Currently developing her PhD studies investigating host and parasite factors that influence the dry season maintenance of P. falciparum in Mali. Caroline Cleopatra Chisenga [Zambia] Dr. Caroline is a Postdoctoral Research Fellow at the Centre for Infectious Diseases Research in Zambia (CIDRZ) and works under the Enteric Disease and Vaccine Research Unit. She obtained her PhD degree in immunology from the University of Zambia. Her current role involves profiling vaccine immune responses in infants in a clinical trial scenarios. César López-Camacho [United Kingdom] Dr. César holds a PhD in Molecular Biology by the U. of Manchester,UK and he did two postdoctoral fellowships in the USA at the U. of Massachusetts Med. School and U. of Vermont. He is now a senior postdoctoral scientist in Reyes-Sandoval’s Lab at The Jenner Institute, U. of Oxford. His research focuses in the development of vaccines against ZIKV, DENV, CHIKV and MAYV using replication-deficient simian adenovirus and MVAs. He collaborates in vaccine designs/cloning for Chagas, Malaria, and HPV. 37

Danilo Legisa [Argentina] Danilo Legisa, PhD. I am R&D and fermentation analyst at Center for R&D in Industrial Biotechnology at INTI-Argentina: a state institution aimed to develop and transfer bioprocess technology to regional industries and academia. As PhD student I`ve been working on Bluetongue Virus (vaccine development and epidemiology) and as post doc on diagnosis kit development for hemolytic uremic syndrome. Currently University Instructor at UNLaM and also Biotech entrepreneur. Dismas Oketch [Kenya] Dr. Dismas Oketch (MD) is the Associate Director of the Kenya Medical Research Instituteâ&#x20AC;&#x2122;s HIV Prevention Clinical Trials & Linkage to Care. He holds an MBChB from Moi University, an MSc in Clinical Trials from the University of London, and spires to be a global leader in the field of vaccines and immunotherapy within the decade. He currently leads the AMP and LIFE studies - two large and pivotal NIH-funded HIV prevention clinical trials at the KEMRICDC Clinical Research Center. Erick Muok [Kenya] Dr. Muok has a Ph.D. in Immunology in 2014 from the Jomo Kenyatta University of Technology in Nairobi. From 2015 to 2018 he was a postdoctoral fellow at Emory University, USA and the Rwandan-Zambian HIV research group. Since 2014 he is a Senior research officer at the Center for global Health Research of KEMRI in Kisumu , Kenya. His laboratory studies is in the early Immune responses in acute HIV infection and HIV co-morbidity with Schistosomiasis. Erwan Atcheson [United Kingdom] Dr Erwan Atcheson is a post-doctoral scientist working on vaccines for Hepatitis C virus, using a novel rat/rodent hepacivirus model, at the Medawar Building for Pathogen Research. He completed a DPhil (2017) developing novel vaccines for malaria (P. vivax and P. falciparum), including mathematical modelling of vaccine combinations, screening of new epitopes using highly immunogenic virus-like particles, and viral-vectored vaccines.

Fabiana Leoratti [Switzerland] Dr. Fabiana Leoratti graduated in Pharmacy Biochemistry in 1998. In 2004 she obtained a Master’s degree and in 2008 a PhD in Sciences from the University of São Paulo. Since 2016, she is Research fellow at University of Bern/Inselspital Department Rheumatology, Imunology and Allergy, where her research involves the development of vaccines in HIV using VLP (Virus like particles). Federica Ghersa [Argentina] Masters in Immunology student and finishing my PhD in Biochemistry focused on endometriosis. Currently applying for a postdoc position initiating formation in nanotechnology in vaccine development in INTA-Bariloche and INIBIOMA-CONICET. Gerardo Montalvo Zurbía Flores [United Kingdom] Gerardo has been awarded a BSc in Biology and a MSc in Medical Virology. Currently, he is undertaking a DPhil in Clinical Medicine which aims to design novel strategies towards the development of a multi-disease vaccine against medically important arboviruses such as Dengue, Zika, Yellow Fever, Chikungunya and Mayaro virus. Gianmarco Gasperini [Italy] Gianmarco Gasperini is a scientist working in the molecular biology unit of GSK Vaccines Institute for Global Health, a company dedicated to the development of affordable vaccines for impoverished countries. He obtained his PhD in Cellular and Molecular biology as part of a joined program between the University of Bologna (Italy) and Novartis Vaccines and specialized in the field of antigen identification for vaccines against bacterial pathogens. Hugo Alberto Valdez [Argentina] Dr. Valdez graduated in Molecular Biology in 2005. In 2010, he obtained a Ph.D. in Molecular Biology and Biotechnology from the National University of San Martin. Since 2014, he is Professor at the University of San Martin. He is also a Assisten Researcher at the Argentinean Research Council, where he carries out research focuses on whooping cough problems, the persistence mechanisms used by the bacterium and development a new vaccine against Bordetella pertussis and Bordetella parapertussi. 39

João Paulo Portela Catani [Belgium] Dr. João Paulo Portela Catani obtained an engineer degree at the Federal University of Paraná and a master degree at the University of CergyPointoise. In 2014, he obtained a PhD in Sciences at the University of São Paulo. He is currently a post doc at the University of Ghent and his current research is focused in mRNA delivery for immuno-modulatory purposes. Linda E Amoah [Ghana] Dr Linda E Amoah obtained a PhD from Georgetown University, Washington DC in 2007. She worked at MR4, VA, USA for two years then joined the NMIMR, University of Ghana in 2009. Her laboratory uses the L. lactis system to express essential malaria antigens and is generally interested in the identification and design of new transmission blocking vaccines and drugs as well as identifying parasite and host genetic traits that influence the infectiousness of Plasmodium gametocytes. Lorena Preciado-Llanes [United Kingdom] Lorena is a postdoctoral researcher at the University of Oxford, working on vaccine trials against arboviruses. After obtaining her medical degree in Mexico, she undertook an MSc and PhD in infection and immunity at the University of Sheffield (UK). Her research interests include human challenge models, host-pathogen interactions and adaptive immune responses to vaccines. María José Germanó [Argentina] Maria José has a degree in Molecular Biology at National University of San Luis. From 2013 at 2016 she was auxiliary professor of chemistry at National University of San Luis. She is PhD student at National University of Cuyo. Currently, she is working on first and thirst generation vaccines against leishmaniasis. Mariateresa Coppola [Netherlands] Mariateresa Coppola works as a PhD student in the group of Tom Ottenhoff where she moved to after obtaining her medical degree from Sapienza University in 2013. She uses genomics, in-silico tools and high-throughput sequencing technologies to discover novel Mycobacterium tuberculosis antigens and she studies their antigenicity by comprehensive comparison of pathogenspecific immunity in health and disease. Besides, she has been trained as a vaccinologist in the European Network Vactrain. 40

Melanie J Shears [United States] Dr Melanie Shears has recently completed her postdoctoral training in malaria research at Johns Hopkins University. She is moving to begin as a Staff Scientist at the Center for Emerging and Re-emerging Infectious Diseases at the University of Washington. She works on malaria vaccine target identification and vaccine testing in rodents and non-human primates. Monica A McArthur [United States] Dr. McArthur is an Assistant Professor of Pediatrics and a member of the Center for Vaccine Development and Global Health at the University of Maryland School of Medicine. Her clinical expertise is Pediatric Infectious Diseases and her research focus is to support the development of vaccines. She performs clinical vaccine trials and is also involved in translational human immunology projects for pathogens such as V cholerae, ETEC, Zika and Dengue Viruses. Nancy Hiu Lan Leung [Hong Kong] Dr Leung is a post-doctoral fellow at the WHO Collaborating Centre for Infectious Disease Epidemiology and Control, the University of Hong Kong, with primary research interest in influenza epidemiology and population immunity. She has experience in the design, implementation and analysis of field studies on influenza burden, transmission, population immunity and vaccine immunogenicity. She aspires to be an immuno-epidemiologist and to study the mechanisms of human immunity. Pablo A Romagnoli [Argentina] Adjunct Investigator (CONICET) at IUCBC. B.S. and M.S. in Biochemistry (1998) at Universidad Nacional de Cรณrdoba (UNC) and Ph.D. on Immunology and Molecular Pathogenesis (2011) at the Emory Vaccine Research Center, Emory University (Atlanta, GA, USA). Postdoctoral studies on T cell responses to oral infection with L. monocytogenes under Dr. Leo Lefrancois and Kamal Khanna supervision at UCONN Health (Farmington, CT, USA). Leads translational research on IBD at CIMETSA-IUCBC (Cรณrdoba, Argentina). Rodrigo Ochoa [Colombia] Bioengineer, MSc in Basic Biomedical Sciences and PhD(c) in Chemical Sciences. He has experience in the fields of Bioinformatics, Cheminformatics, Modeling and Computational Strategies applied to the design and discovery of drugs and vaccines. 41

Rosemary Thwaite [Spain] PhD student in immunology at the Universitat Autonoma de Barcelona (UAB), Spain, working on the development of recombinant protein nanoparticles as a vaccine strategy against viral diseases in aquaculture. Previously Rosemary worked in gene therapy, on the immunogenicity of adeno-associated viral vectors (AAVs) in the human population. With a background in English language teaching, she also gives classes in scientific writing and communication skills in the Biochemistry Dept. of the UAB. Sharareh Eskandari [Australia] Dr Sharareh Eskandari has been a Postdoctoral Research Fellow at Laboratory of Vaccines for the Developing World (Institute for Glycomics, Australia) since 2016 post completing her PhD at University of Queensland. She has PhD and professional experience in pharmaceutical industry. Currently, her research studies involve developing a preclinical liposome vaccine candidate to protect against group A streptococcus infection. Her interests focus on translational research on vaccine delivery systems. Vanessa Arato [Italy] Vanessa obtained a Masterâ&#x20AC;&#x2122;s degree in Cellular and Molecular Biology at the University of Siena in 2014. She was then a post-graduate intern at Novartis Vaccines, where she worked on host-pathogen interaction mechanisms of bacteria such as Bordetella pertussis and Neisseria meningitidis. Vanessa is currently completing her PhD with the University of Padua in a joined program with GSK Vaccines Siena with research focusing on the pathogenesis of Clostridium difficile. Vijay Kumar Prajapati [India] Dr. Vijay Kumar Prajapati is working as Assistant Professor in Department of Biochemistry, Central University of Rajasthan, Ajmer, India. He is working on drug discovery and vaccine development against human infectious diseases. He is a recipient of INSA Medal for Young Scientist and Associate-Indian Academy of Sciences, Bengaluru. He was awarded ASM-IUSSTF Indo-US Research Professorship from The American Society for Microbiology (ASM) and IndoUS Science and Technology Forum (IUSSTF). 42

Yamil Ezequiel Masip [Argentina] Yamil graduated in Biotechnology in 2018. His interest in Neglected Tropical Diseases led him to start a PhD in Molecular Biology and Biotechnology, focusing on Chagas disease. His thesis is based on the study of functionality and protective capacity of TcTASV, a newly recently discovered gene family of Trypanosoma cruzi. Alexandre Rodrigues Calazans [Brazil] Alexandre Calazans has a PhD in. Genetics in 2008 from the Federal University of Rio de Janeiro. From 2011-2013 he was a research fellow at International AIDS Vaccine Initiative, working at the Vaccine Design and Development Laboratory, in New York. In 2014, he was selected to work as a specialist, at the Center for Technological Development in Health, Oswaldo Cruz Foundation. Alysson Henrique Urbanski [Brazil] Alysson graduated in Biomedical Sciences in 2016. In 2018 he obtained a Master’s degree in Biochemestry, with emphasis on molecular biology, from the Federal University of Paraná. His current research, as a PhD student at the University of São Paulo, aims the human antibody repertoire analysis. Barbara Ferri Moraschi [Brazil] Barbara holds a bachelors degree in Biological Sciences from São Judas University (2013). Currently, she is a PhD student at the Molecular Immunology Laboratory at Federal University of São Paulo, working with the following topics: recombinant genetic vaccines, Trypanosoma cruzi and CD8+ T cells. Caroline Brandão Monteiro [Brazil] I am biomedical. Master of Science (MSc) in Immunology and Parasitology from Federal University of Mato Grosso about ecoepidemiology research in virology, emerging viruses, hantavirus and arbovirus. I am a Ph.D. student in the Health Sciences program at UNIFESP and I am currently working with specific CD8+ T cell, migration, obesity and genetic vaccination against T. cruzi.

Catarina Bourgard [Brazil] MSc Catarina Bourgard is a PhD student at Tropical Diseases Laboratory, IB-UNICAMP, developing her project on “Analyses of the immuno-pathological and molecular mechanisms involved in cytoadherence of Plasmodium vivax”. She is a young researcher between pure experimental setup,endemic field work, parasite culture, biomol and NGS, and bioinformatics for in silico screens, optimized NGS experimental design and data analysis, both within Malaria parasite biology and drug discovery research fields. Diogenes Saulo de Lima [Brazil] Diogenes obtained a pharmacy degree in University of São Paulo. In 2015, he joined Computational Systems Biology Laboratory to pursue a doctoral degree. Currently, Diogenes is studying a role for lncRNAs in vaccination response. Fabio Miyajima [Brazil] Fabio obtained a BDS degree at University of Sao Paulo and a MSc at Unicamp. He undertook a PhD in Molecular Epidemiology at the University of Manchester and accrued most of his postdoctoral experience on translational medicine at the University of Liverpool, retaining an honorary fellowship. He is currently a Researcher at Oswaldo Cruz Foundation in Ceara with interests on the development of innovative solutions for molecular surveillance of emerging diseases, such as arbovirus. Fabio Neves dos Santos [Brazil] Dr. Fabio Santos has a Ph.D. in Chemistry in 2017 from the University of Campinas. Currently, he is a postdoctoral fellow of the FAPESP with research interests focused on metabolomics-based in high resolution mass spectrometry for identify specific biomarkers of the Zika, Chikungunya and Dengue virus infections in biological fluids. He was a finalist of the SBBQ-Biozeus Biopharmaceutical Award of Innovation in Life Sciences in 2017 and 2018 for the development of new devices for the diagnosis. Fernanda Caroline Coirada [Brazil] Fernanda Coirada graduated in Pharmacy and Biochemistry in 2016 at São Paulo State University. Now, she is a PhD student at Federal University of São Paulo and her work is focused on the generation and preclinical evaluation of vaccine candidates against Zika and Chikungunya viruses. The main goal is to target the envelope antigen to dendritic cells. 44

Fernanda Lins Brandão Mügge [Brazil] Dr. Mügge obtained her PhD in Cell Biology in 2018 and is currently a Post Doc in molecular biology and biochemistry at Universidade Federal de Minas Gerais, Brazil. She has been investigating the role of RNA binding proteins from Trypanosoma cruzi in the regulation of parasite differentiation and/or virulence. Her research interests focus on gene expression and parasite-host interactions. Flavia Fonseca Bagno [Brazil] Bachelor in Biochemistry from the Federal University of Viçosa (UFV, Brazil), including exchange program at the University of Reading (United Kingdom). She obtained a Master of Science in Microbiology at the Federal University of Minas Gerais (UFMG, Brazil) and is currently a PhD student at the same University. Main research focus on production of recombinant proteins of arboviruses for diagnostic and vaccine purposes. Francys Rangel [Brazil] Bachelor in Biology and Magister Scientiae in Cell Biology from University of Los Andes (Venezuela). In 2009 she became assistant professor at the Faculty of Sciences (ULA-Venezuela). In 2017 she won an OAS/PAEC scholarship and started a PhD in Health Sciences at the Federal University of Bahia (Brazil) and is currently doing her research work at FIOCRUZ-Bahia.The main focus of her research is the development of vaccines against cutaneous leishmaniasis using transgenic Leishmania tarentolae. Gabriela Burle-Caldas [Brazil] Dr Burle-Caldas obtained her Ph.D in Biochemistry and Immunology in 2016 in the Federal University of Minas Gerais (UFMG) with sandwich period in the Bern University (Switzerland). Currently she has a pos doc position in the laboratory of Santuza Teixeira and in the CT Vacinas at the UFMG. Her research interests focus on the study of Trypanosoma cruzi biology and it’s interaction with the mammalian host using CRISPR/Cas9 technology. Georgia Guimarães [Brazil] Dr Guimaraes has a Ph.D. in Genetic by Federal University of Pernambuco (2013). Scholar Research at the University of Pittsburgh (Pennsylvania, USA). Pos-doc in Virology at Rio Preto Medical School (FAMERP). Experience in Virology, working on the following topics: dengue, zika, yellow fever, chickungunyaas well as in epidemiology, molecular biology of viruses and vaccine. 45

Irina Dobrescu [Brazil] In 2011, I graduated in Biology of the François Rabelais University of Tours, France and in 2013, I obtained a Master degree of the same University. For a period of time I worked at the Pasteur Institute, Paris, France as an engineer. Since 2015, I am a PhD student at the Parasitology department of the Institute of Biomedical Sciences, University of São Paulo, Brazil. Izabella Pereira [Brazil] Postdoctoral fellow at Laboratório de Imunofarmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ). She has a Doctor Degree in Sciences (2016) from UFRJ and her main research topics include mucosal vaccines against leishmaniasis, immune tolerance, nanotechnology applied for new adjuvant development. Juliana Apostolico [Brazil] I completed my master’s degree in immunology at School of medicine at São Paulo University. During my master, I analyzed the immune response of mice immunized with a HIV recombinant protein in the presence of differents adjuvants. Next, I started my PhD project at Federal University of São Paulo. Now, I am a postdoc fellow and involved to study the development of HIV vaccines candidates. Luan Firmino Cruz [Brazil] No bio provided Luciana Conde [Brazil] MSc. Luciana Conde currently is a PhD student in the Immunology and Inflammation program at Federal University of Rio de Janeiro. Her doctoral thesis consists in the identification of linear epitopes conserved as target of protective antibodies in the experimental model of Visceral Leishmaniasis. She also worked in the research of therapeutic intervention in Zika and Chaga’s disease. Luiza Almeida de Figueiredo [Brazil] Luiza Figueiredo is a biologist and has a master degree in parasitology from Federal University of Minas Gerais. In 2015 she started to develop her Ph.D. project focusing on the production of a polyvalent vaccine against trypanosomiasis. She has theoretical and practical experience in parasitology, molecular biology and immunology. 46

Maria Alice Queiroz [Brazil] Dr. Maria Alice Freitas Queiroz is a pharmacist with a master and PhD degree in Biology of Infectious and Parasitic Agents. She is a pos-doc working in the Virus Laboratory (ICB/UFPA) and is involved in the search of biomarkers of the progression to disease of HTLV-1 infection and in the strategies to develop teranostic molecules using HTLV-1, HIV-1 and Chlamydia trachomatis as infectious agents models to improve diagnosis, treatment and vaccine production. Mariana Ribeiro Dominguez [Brazil] Dr. Dominguez obtained her Bachelor degree in Biomedical Science from the State University of São Paulo in 2008. In 2013, she obtained a Ph.D. in Science at the University of São Paulo. With two former post-doctoral research trainings from The George Washington University (2014-2015) and the School of Medicine at the University of São Paulo (2016), she currently is a post-doctoral fellow from the School of Pharmaceutical Science at the University of São Paulo. Marina Gimenez [Brazil] Dr Marina Gimenez graduated in Molecular Biology in 2006 and obtained her Ph.D in Biological Sciences in 2012. Currently she has post-doc position in University of São Paulo, with a fellowship of São Paulo Research Foundation (FAPESP) as part of the National Malaria Control Program. Her studies deal with the development and testing of recombinant proteins from immunodominant antigens of Babesia bovis and Plasmodium vivax to be used as vaccines against babesiosis and malaria, respectively. These studies included post-doctoral internships in Argentinian National Institute of Agropecuary Technology (INTA) and the University of Oxford (UK). Marisé Solórzano [Brazil] Marisé Solórzano got her master degree in Molecular Biology at The University of Los Andes (Venezuela) and actually is a PhD Student at Biomedical Sciences Institute of the University of São Paulo working in the developtment of new targets for Malaria Vaccines.

Nagela Ghabdan Zanluqui [Brazil] Msc Nagela Ghabdan Zanluqui was graduated in Biomedicine in 2014. In 2016, she obtained Master’s degree in Bioscience and Biotechnology. Currently, she is a Ph.D. student in Immunology at the Medicine Faculty of São Paulo University. Since 2016 is NeuroImmune Interaction Laboratory student, under Professor Jean Pierre S. Peron supervision, where she studies the role of CD8 T cells during Zika virus infection. Natália Ketrin Almeida de Oliveira [Brazil] My name is Natália, I am PhD student in Tropical Medicine at FIOCRUZ (Fundação Oswaldo Cruz). I joined the group of the Laboratory of Malaria Research, as undergraduate student followed by the admission in Master Degree. Currently, I am engaged in PhD thesis entitled “Genetic diversity of P. vivax vaccine target molecules in isolates of Brazilian endemic and non-endemic areas”, Natalia Marchesan Bexiga [Brazil] Natalia M. Bexiga received her master’s degree from University of Sao Paulo (2014) in the field of biopolymers and biomaterials. Currently she is a PhD student in the area of adjuvants for delivery of biological products. She has experience in biopolymer synthesis, nanotechnology, and cellular rheology. Currently she is working on the following subjects: delivery systems for proteins and antigens, techniques applied to the study of cellular rheology and metabolomics. Natália Satchiko Hojo-Souza [Brazil] Dr. Hojo-Souza obtained her MSc degree in Cell Biology and PhD degree in Immunoparasitology from Federal University of Minas Gerais in 2012 and 2016, respectively. Since then, she has been working as postdoc research in the Immunopathology lab at René Rachou Institute/Fiocruz. Her research interests focus on the immune response in parasite-host cells interactions, especially in malaria and Chagas diseases. Natan Raimundo Gonçalves de Assis [Brazil] Dr. Assis graduated in Biotechnology in 2010. In 2012, he obtained a Master’s degree, and in 2016, a Ph.D. in Immunology from the Federal University of Minas Gerais. Since 2016, he is a post-doc at the Federal University of Minas Gerais. His research interests are focused on vaccine development, mainly by the use of smart nanoplatforms and DNA vaccines. 48

Patrícia Conceição Gonzalez Dias Carvalho [Brazil] “Graduated in Biotechnology by Federal University of Grande Dourados. Master in Cellular and Molecular Biology by Oswaldo Cruz Institute/FIOCRUZ and currently is PhD student of the Pharmacy (Physiopathology and Toxicology) Program at University of São Paulo. She has experience in molecular biology, bioinformatics and immunology with emphasis on vaccine development. Currently, she works using Systems Biology to predict and understand the immune response to different vaccines. Rafael Casarin Penha Filho [Brazil] Dr. Penha Filho is a Doctor in Veterinary Medicine (DVM). During 2014 and 2015 he worked as a post-doc in Cornell University, Ithaca, NY, USA. His interests are vaccines and immunotherapics to control foodborne pathogens in animals as a viable alternative to reduce antibiotics usage and ermerging resistance. Currently coordinating a FAPESP Young Investigator project at Sao Paulo State University (UNESP) for the development of a novel recombinant vaccine to control multiple Salmonella serovars. Rodrigo Benedetti Gassen [Brazil] Pharmacist by Centro Universitário Franciscano (2012). Master’s degree in Medicine/Pediatrics from PUCRS (2015), and currently attends the PhD in it. He develops his activities in the laboratory of Cellular and Molecular Immunology and in the Laboratory of Clinical and Experimental Immunology of PUCRS, acting mainly in viral and tumor immunology, immune checkpoint blockade, follicular T cells and T cell memory. Rory Brito [Brazil] PhD in Pharmaceutical Sciences with emphasis in Therapeutics, Vaccine, Diagnosis and Prognosis of Diseases Neglected at Federal University of Ouro Preto in 2018. Experience in Reverse Vaccinology, Immunoinformatics and Multiparametric/multicolor flow cytometry. His research interests are development of recombinant and peptide vaccines against Leishmaniasis.

Sibylle Sophie Hacker [Brazil] Sibylle Sophie Hacker joined the laboratory of BiochemicalPharmaceutical Technology Center of the University of São Paulo - Brazil. She is currently completing her PhD with a project to develop a model of mucosal vaccine with chitosan nanoparticles based on the capsular polysaccharide of Streptococcus agalactiae as a vaccine antigen. His research interests are focused on humoral and cellular immune response, vaccine models, vaccine delivery. Simone Gonçalves Fonseca [Brazil] Dr Fonseca obtained her Ph.D. in Immunology at University of São Paulo in 2002. During 2007 to 2009 she was post-doctoral fellow at University of Montreal, Canada. She worked at Vaccine and Gene Therapy Institute, Florida, USA from 2010 to 2011. Since 2012 she is an Assistant Professor at the Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia, Brazil. Brazil. Her laboratory is focused on immunopathology of infectious diseases as HIV, Zika and Chagas disease. Sthefany Pagliari [Brazil] “Sthefany has been awarded a BSc in Biological Sciences with a specialization in Collective and Family Health and a MSc in Animal Sciences. Currently she is a PhD student at Federal University of Santa Catarina, Brazil. In her project she aims to develop new vaccine candidates against Plasmodium vivax based on virus-like particles. Recently, undertook an internship at the University of Oxford’s Jenner Institute, in which the efficacy and protection of the vaccine candidates was examined. “ Tiago Fazolo [Brazil] My name is Tiago Fazolo, I’m a Bachelor in Biological Sciences by UPF university in Brazil and my PhD was in child health with emphasis in Cellular and Molecular Immunology at PUC University under professor Doctor Cristina Bonorino in Porto Alegre, Brazil.

Vivian Bonezi [Brazil] Vivian obtained her Master of Science degree in Molecular Biology at the University of Sao Paulo (Brazil) in 2015 by studying the signalling modulation of T cells exposed to different immunosuppressants upon renal transplantation. Currently, she is a PhD student in Immunology at the University of São Paulo and her project aims to investigate the molecular pathways involved in the B cell signaling triggered by Dengue virus infection that elicits a massive expansion of antibody-secreting cells. Victória Lunardelli [Brazil] Ms. Lunardelli is a PhD student at the Department of Microbiology, Immunology and Parasitology from the Federal University of São Paulo. Since 2014, she has been studying vaccines development at the Experimental Vaccines Laboratory with an HIV vaccine candidate. And now her PhD project goal is to produce different ZIKV recombinant proteins, evaluate the humoral immune response in ZIKV-infected patients (antigenicity) and the immunogenic potential in preclinical settings. Wagner José Tenório dos Santos [Brazil] Bachelor’s degree in Biomedical Sciences, master in Genetics and genetics PhD student at the Federal University of Pernambuco (Brazil). My thesis project is focused on vaccine development for human visceral leishmanasis and the validation of novel serological diagnostic tests for the detection of human and canine visceral leishmaniasis, simultaneously. Working with these research fields, gave me large experience in cellular and molecular biology, bioinformatics, immunology, parasitology