Bioptimizers Gluten Guardian Bioptimizers Gluten Guardian is a mix of eight plant-based proteolytic enzymes that includes Peptidase DPP-IV (an enzyme reseaerch proven to help break down gluten) — as well as four enzymes that break down starches & sugars. Specifically designed to support digestive issues relating to gut-irritating foods containing gluten or casein. Gluten Guardian contains a highly potent gluten-digesting enzyme called peptidase DPP-IV, shown in research studies to help break down gluten. Gluten Guardian is a dietary supplement that is manufactured using gluten, and it is used to rid the body of gluten. It is available for both women and men.