ADCC Enhanced Antibody Antibody-dependent cellular cytotoxicity (ADCC) is an important function of antibody. It is a part of the humoral immune response to limit and contain infection. Creative Biolabs provides a wide range of ADCC enhanced antibody used in various research areas to accelerate your research process. Antibody-dependent cell-mediated cytotoxicity (ADCC), also referred to as antibodydependent cellular cytotoxicity, is a mechanism of cell-mediated immune defense. Antigens coated by specific antibodies are lysed by a cytotoxic effector cell through a non-phagocytic process. ADCC is triggered through interaction of an antibody’s Fc region with certain Fc receptors (FcRs) on effector cells (including natural killer (NK) cells, monocytes, macrophages, neutrophils, eosinophils and dendritic cells) and reached by the release of the content of cytotoxic granules or by the expression of cell death-inducing molecules. ADCC is highly dependent on the glycosylation profile of its Fc portion and on the polymorphism of Fcγ receptors.
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