MAXIMIZING NUTRITIONAL SUPPORT ALONGSIDE GLP-1 THERAPY The Role of Chia Fiber and Protein
Support Health Throughout and Beyond Treatment Emphasizing Nutrient Density
Challenges of GLP-1 Therapy GLP-1 medications function in part by slowing gastric
People seeking a healthier weight are increasingly
emptying and reducing appetite, resulting in significantly
turning to medications such as glucagon-like peptide-1
decreased food intake and potentially lower nutrient
(GLP-1) receptor agonists, which were developed to
intake. While this mechanism drives weight loss, it creates
influence insulin secretion, but can also suppress
a critical nutritional challenge: How to make every bite
appetite. Developed initially support healthy blood sugar
count by optimizing micro- and macronutrient density
metabolism. GLP-1s have also been FDA-approved for
to preserve lean mass, support energy, and maintain
long-term healthy weight support.
metabolic health from a substantially reduced volume of food. Otherwise, users risk losing a significant amount of lean muscle mass, which is essential for supporting metabolic function, physical strength, and long-term
Nearly half of U.S. adults (41.9%)
health outcomes.
are seeking healthy weight support today. GLP-1 medications such as Ozempic, Wegovy, and Mounjaro represent a significant in supporting a healthy weight. However, they also present notable challenges
The data on muscle loss during GLP-1 therapy is particularly concerning,
that can lead to negative health consequences, such as
with research showing that 25% to 40% of
reduced muscle and bone mass, and may complicate
weight lost consists of lean muscle tissue.
treatment adherence. They also introduce a further
For a patient experiencing 50 pounds of
consideration: how to get sufficient essential nutrients from much smaller meal volumes while maintaining health and long-term well-being once appetite returns.
weight loss, this could translate to 12 to 20 pounds of muscle loss. Equally challenging, for many, are the gastrointestinal side effects associated with GLP-1 therapy. Nausea, diarrhea, and constipation affect a substantial proportion of users. While the mechanisms behind these effects are not fully understood, they likely involve altered gastric emptying, central nervous system effects, changes in nutrient absorption, and modified intestinal motility. These digestive symptoms can add to the challenge of consuming adequate nutrition. For some users, the symptoms may even cause them to quit taking GLP-1s altogether.
MAXIMIZING NUTRITIONAL SUPPORT ALONGSIDE GLP-1 THERAPY: THE ROLE OF CHIA FIBER AND PROTEIN
Keys to GLP-1 Support: Fiber and Protein
Recent expert guidance on GLP-1 utilization has emphasized the importance of helping users:
GLP-1 is an incretin hormone the body releases
choose nutrient-dense foods
following food consumption. It promotes satiety, stimulates glucose-dependent insulin secretion, slows gastric emptying, and helps regulate appetite through
maintain lean muscle mass
central mechanisms in the brain. GLP-1 medications are synthetic analogs that amplify these endogenous
address the side effects that can lead to stopping treatment
effects. What’s more, both fiber and protein naturally support the same physiological pathways involved in satiety and metabolism that GLP-1 medications
optimize dietary approach, emphasizing lean proteins, whole grains, fruits and vegetables, and healthy fats
target. That makes them ideal nutrients for addressing challenges relating to GLP-1 therapy.
NUTRIENT
HEALTH BENEFITS
GLP-1 SUPPORTING
PROTEIN
• Maintain muscle mass
High-protein meals demonstrate particular
• Promote satiety
efficacy in enhancing GLP-1 secretion compared
• Maintain weight loss
to low-protein alternatives. Protein intake alone
Chia Fiber and Chia
is sufficient to trigger GLP-1 release, and specific
Protein can Help
peptides derived from protein digestion can inhibit the enzyme DPPIV, which normally degrades GLP-1.
These uniquely
This means high-quality protein may help extend
valuable ingredients
the beneficial effects of circulating GLP-1 while supporting lean muscle mass maintenance.
DIETARY FIBER
support GLP-1 users in maximizing
Dietary fiber operates through two distinct
nutritional density
gastrointestinal (GI)
mechanisms. First, it exerts direct effects in the
health
proximal intestine by activating specific receptors
while supporting
• Promote
healthy digestion.
• Promote satiety
that trigger GLP-1 release. Second, when fiber
• Maintain weight loss
reaches the colon, intestinal bacteria ferment it into
The result is more
short-chain fatty acids (SCFAs), which are natural
sustainable weight
GLP-1 stimulators. These dual functions mean fiber
loss that promotes
can promote GLP-1 release throughout the entire gastrointestinal tract, creating sustained impacts on
whole-person health.
satiety and glucose metabolism. That’s especially advantageous for patients attempting to maintain nutritional adequacy from reduced meal volumes.
SUPPORT HEALTH THROUGHOUT AND BEYOND TREATMENT
3
Supporting Nutrition Not all fiber sources are equally tolerable when the digestive system is already managing the effects of slowed gastric emptying and altered gut motility. Many high-fiber foods or supplements can exacerbate bloating, gas, and discomfort, which is particularly problematic for GLP-1 users already experiencing nausea or constipation from their medication.
THE DIGESTIVE HEALTH BENEFIT OF CHIA FIBER
THE MUSCLE-PRESERVING PROPERTIES OF CHIA PROTEIN
Chia fiber has unique properties that make it particularly
Adequate protein intake is essential for GLP-1 users to
well-suited for individuals undergoing GLP-1 therapy. It
protect lean mass and support satiety. And use of GLP-1s
increases luminal viscosity, which contributes to enhanced
should be combined with resistance training, experts
satiety without causing significant digestive discomfort.
recommend. But addressing muscle loss during weight
Unlike some fibers that undergo rapid fermentation in
reduction calls for more than just increasing protein intake
the upper gastrointestinal tract (potentially causing gas
and exercise. The quality of protein and its bioavailability
and bloating), chia fiber ferments slowly and primarily
are critically important, particularly when patients are
in the colon. This slow-and-steady fermentation
eating smaller portions and feel less hungry.
profile contributes to high digestive tolerance and creates prebiotic effects that support intestinal microbiota function.
These characteristics position chia protein as an excellent option for preserving lean muscle mass during weight loss, especially the rapid and significant weight loss that comes
Clinical research across five trials has demonstrated
with taking a GLP-1. When users struggle to consume
that chia fiber supplementation promotes the growth
adequate protein due to reduced appetite, every gram
of beneficial bacteria, including specific SCFA-producing
ought to provide the maximum benefit. A protein source
species such as Enterococcus and Lactobacillus. These
that offers high digestibility and amino acid balance
bacterial species produce the short-chain fatty acids
delivers optimal muscle-building support in a smaller
that naturally contribute to gut health support. The
package, maximizing nutritional density. This combination
increased bacterial diversity also positively impacts
thus helps meet protein goals even when appetite is low.
overall gastrointestinal health by increasing supportive
And particularly in the weight maintenance phase, these
metabolites, strengthening the intestinal barrier, and
attributes can assist in preventing rebound weight gain
reducing inflammation — all factors that may help with
and supporting ongoing muscle health.
occasional stomach upset and support intestinal health.
Chia’s unique gel-forming properties also enhance satiety without excess
Chia protein provides a well-balanced
bulk or bloating. The soluble fiber in chia
amino acid profile, delivering the essential
may help limit absorption of dietary fat,
building blocks muscles require in the right
providing supplementary support for
proportions. Chia protein’s high digestibility
weight management. Additionally, its slow,
helps ensure efficient absorption and
colon-targeted fermentation supports SCFA
utilization of constituent amino acids.
production and microbiome balance.
MAXIMIZING NUTRITIONAL SUPPORT ALONGSIDE GLP-1 THERAPY: THE ROLE OF CHIA FIBER AND PROTEIN
Practical Applications Incorporating Chia into GLP-1 Treatment Plans The utility of chia fiber and protein as nutritional tools lies in their versatility. They can be incorporated into
Chia fiber and protein can be incorporated into everyday recipes or formulations—
smoothies, mixed into yogurt, added to oatmeal, or
from smoothies and baked goods to
included in baked goods. For users managing early satiety
supplements—offering a clean-label,
and occasional nausea, having concentrated sources of
functional solution for the evolving GLP-1
fiber and protein that can be consumed in small volumes provides significant practical advantages.
consumer market.
To be clear, these ingredients are food-based complements to GLP-1 therapy, not pharmaceutical interventions. They are not intended to replace prescribed medical treatment. Rather, they’re simple, relatively inexpensive food-based components that address the specific nutritional challenges faced by GLP-1 users. They facilitate meeting fiber requirements without digestive distress. They provide high-quality protein to support muscle preservation. And they may support the body’s endogenous GLP-1 pathways, functioning complementarily rather than antagonistically with medication regimens.
THE BOTTOM LINE While GLP-1 medications offer substantial therapeutic benefits, their long-term effects continue to be investigated. What we know for sure: Successful outcomes call for more than pharmaceutical intervention alone. They necessitate maintaining a consistent, balanced diet that supports muscle preservation,
Maintaining Results after GLP-1 Therapy
gastrointestinal health, and overall wellness.
In the context of weight maintenance, when GLP-1 therapy
needs of individuals using GLP-1 medications,
is reduced or discontinued — whether at a physician’s direction or once weight goals are achieved, maintaining results becomes an important phase of care. Appetite often increases, and without nutritional strategies that promote satiety and help preserve lean muscle mass, weight regain may occur. Emphasizing nutrient-dense foods and functional ingredients such as chia protein and fiber can help support this transition by providing lasting
As interest grows in foods and beverages designed to meet the evolving nutritional chia fiber and protein offer nutritional and functional properties that make them relevant ingredients for product development. Their multifunctional characteristics may help formulators address nutritional density, texture, digestive tolerance, and overall product quality in formulations intended for this growing consumer segment.
fullness, balanced energy, and lean muscle protection for ongoing metabolic health.
PRACTICAL APPLICATIONS
5
Benexia® Chia Ingredients for GLP-1
Functional 56% Chia Fiber Concentrate
Premium 42% Chia Protein Concentrate
PRODUCT OVERVIEW
PRODUCT OVERVIEW
Benexia Xia Powder 435 W LM is a high-fiber, partially
Benexia® Xia Powder 125 W LM is a high-protein, partially
defatted micro-milled powder derived from white chia
defatted micro-milled powder derived from white chia
seeds. This ingredient delivers soluble and insoluble
seeds. This ingredient delivers a complete amino acid
fiber and plant-based protein. It is designed for bakery,
profile, excellent digestibility (91.9%), and is designed for
functional foods, and nutraceuticals.
nutraceuticals, functional foods, and beverages.
PRODUCT FEATURES
PRODUCT FEATURES
•
56% Dietary fiber
•
≥ 42% chia-based plant protein
•
25% High-quality protein
•
PDCAAS: 0.95
•
5% Omega-3 ala (600 mg/12 g)
•
Contains all essential amino acids
•
<1 g net carbs, keto-friendly
•
20% dietary fiber (soluble and insoluble)
•
Rich in minerals & antioxidants
•
9% omega-3 fatty acids (ALA)
•
Free of allergens, gluten, GMOs, starches
•
Mild, nutty flavor
•
Free of allergens, gluten, GMOs
®
NUTRITIONAL & HEALTH ADVANTAGES Insoluble Fiber 50% (hemicellulose)
ADVANTAGES
•
Health & Nutritional
Gut health & Regularity*
Soluble fiber 6%
•
Excellent plant-based protein source
(HMW polysaccharide - viscous/fermentable)
•
Contributes to muscle maintenance and
•
Supports gut microbiota (prebiotic effect)
•
Promotes glycemic management
•
Supports healthy cholesterol levels and promotes heart health
•
metabolic wellness •
Easy absorption with no bloating or digestive discomfort
•
Contributes to healthy satiety
Provides essential omega-3s (ALA) for cardiovascular health, and as precursor of EPA and DHA
TECHNICAL FUNCTIONALITIES
TECHNICAL FUNCTIONALITIES
•
Moisture control
•
•
Clean-label
•
Binding agent and texture enhancement
•
Shelf-life extender
•
Enhances dough structure
Clean-label: free of contaminants and chemical treatments
•
Binding agent and gluten-like performance: gum replacement
•
Smooth texture, unlike gritty alternatives
•
Easily dispersible, ideal for shakes, drinks, and powders
MAXIMIZING NUTRITIONAL SUPPORT ALONGSIDE GLP-1 THERAPY: THE ROLE OF CHIA FIBER AND PROTEIN
Applications BENEXIA® XIA POWDER 435 W LM*
Shakes & Meal Replacements
3% – 6%
Fiber Supplements
12 g/day
Bread & Bakery Products - to replace gums or emulsifiers
0.5% – 3%
- as high fiber flour
5% – 10%
Fruit Purée
Up to 5%
Cereal & Snack Products
2.5% – 5%
BENEXIA® XIA POWDER 125 W LM* Beverages & Dairy Protein drinks, Shakes
Bakery & Snacks Bars, Cereals, Snacks
Nutritional Supplements Powder blends, Capsules
Meat Analogues
0.2-0.5%
10%
4-6%
up to 10%
*These ingredients have been approved as a Novel Food (Commission Implementing Regulation (EU) 2020/500), and its use is subject to local regulations worldwide. DISCLAIMER This communication is intended for B2B use, and no statements are meant to be perceived as approved by regulatory authorities. Local regulations must be reviewed to confirm permissibility of ingredients and claims for each food category.
BENEXIA CHIA INGREDIENTS FOR GLP-1
7
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Meloni, A. R., DeYoung, M. B., Lowe, C., & Parkes, D. G. (2013). The role of glucagonlike peptide-1 in the regulation of lipid metabolism and body weight. Diabetes, Obesity & Metabolism, 15(—), —-—. https://pmc.ncbi.nlm.nih.gov/articles/PMC3556522/pdf/dom0015-0015.pdf
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Cisternas, C., et al. (2024). Impact of dietary fiber fraction of chia seed on hepatic steatosis and metabolic disturbances induced by a high-fat diet in rodents. Journal of Functional Foods, 105, 105543. https://www.sciencedirect.com/science/article/pii/ S1756464624003311?ref=pdf_download&fr=RR-2&rr=9a3c6dde5f70f50e
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Bettge, K., Kahle, M., Abd El Aziz, M. S., Meier, J. J., & Nauck, M. A. (2017). Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: A systematic analysis of published clinical trials. Diabetes, Obesity & Metabolism, 19(3), 336–347. https://pubmed.ncbi.nlm.nih.gov/27860132/
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Prado CM, Phillips SM, Gonzalez MC, Heymsfield SB. (2024). Muscle matters: the effects of medically induced weight loss on skeletal muscle. Lancet Diabetes Endocrinol. Nov;12(11):785-787. doi: 10.1016/ S2213-8587(24)00272-9.
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Hope DCD, Tan TMM. (2024) Adaptive infusion of a glucagon-like peptide-1/ glucagon receptor co-agonist G3215, in adults with overweight or obesity: Results from a phase 1 randomized clinical trialNat Rev Endocrinol.26:1479 –1491. https://dom-pubs.onlinelibrary.wiley.com/doi/pdf/10.1111/dom.15448
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MAXIMIZING NUTRITIONAL SUPPORT ALONGSIDE GLP-1 THERAPY: THE ROLE OF CHIA FIBER AND PROTEIN
Benexia, a leader in the industry All Benexia® Ingredients are naturally processed, cleanlabel, gluten-free, and come from sustainable agriculture. Benexia is a fully vertically integrated company (from agricultural production, extraction and concentration processes, ingredients development, and distribution), from chia agricultural production plant to the final ingredients and solutions. Benexia guarantees traceability from the fields to your facility and offers certified quality (GAP, GMP-HACCP, and FSSC 22000), Halal, and Kosher.
Our team, the best customer service We are a group of passionate people fully devoted to our customers, with a great sense of service and love for health and well-being. We offer support in formulation, nutrition, scientific and regulatory matters, with the best experts to assist your needs. Contact us for samples, application sheets and more information at info@benexia.com
BENEXIA CHIA INGREDIENTS FOR GLP-1
9
REFERENCES Scan the QR code to access scientific references.
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