June 2, 2011 Edition of the Bay Area Reporter

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BARtab Still Studly

Street artist faces charge

'Tales' opens at ACT

Arrests at Moscow Pride

The Eagle has Flown Pride by Night June Events

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Serving the gay, lesbian, bisexual, and transgender communities since 1971

Vol. 41 • No. 22 • June 2-8, 2011

Candles await marchers at last month’s annual AIDS vigil in the Castro. This Sunday marks the 30th anniversary of the first reported AIDS cases.

Rick Gerharter

The quest turns for a cure Attention to older HIV patients

by Liz Highleyman

by Matthew S. Bajko

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reg Edwards will turn 60 this August. It is an age he could hardly imagine he would ever celebrate when he was diagnosed with having HIV in 1992. At that time the country’s AIDS epidemic was entering its second decade. And it would be another three years before the introduction of breakthrough medications that would turn HIV into a manageable, chronic illness. “A lot of the anxiety and fear has dissipated over the years. But so many people over 50 were infected in the late 1980s or early 1990s but clearly are no longer around,” said the openly gay San Francisco resident who is the director of the Oakland-based Flowers Heritage Foundation, which supports HIV and AIDS services. As the AIDS epidemic now enters its fourth decade, older Americans represent the fastest growing age group among HIV-positive people. In San Francisco the majority of AIDS cases are already in this age bracket. As the Bay Area Reporter reported in February, 53 percent of AIDS cases in 2010 were among people 50 and older. And one in six people are over 50 when diagnosed with being HIV-positive, city data

The quest for a cure

Greg Edwards was diagnosed with having HIV in 1992.

shows. By 2015 the Centers for Disease Control and Prevention estimates that half of the people with HIV in America will be over the age of 50. That will be “a pretty big milestone,” said Dr. Brad Hare, medical director of the UCSF Positive Health Program at San Francisco See page 16 >>

hirty years after the first report of what would come to be known as AIDS, more and more researchers and advocates are talking about a cure for HIV – a development that is both shocking and long overdue. “Hope for a cure is based on amazing progress in drug development and in understanding the underlying biology of HIV infection,” said Paul Volberding, one of the first doctors to treat HIV and cofounder of the AIDS clinic at San Francisco General Hospital. When the syndrome of opportunistic infections, wasting, and plummeting T-cell counts was linked to a virus, many believed it would not be long before effective treatment, a vaccine, and ultimately a cure would become available. But HIV – which attacks the CD4 T-cells that coordinate the immune response – proved a wily foe. The advent of combination antiretroviral therapy (ART) in the mid-1990s dramatically reduced morbidity and mortality, and improvements over the past decade have enabled most people with access to treatment to reach an undetectable viral load.

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Liz Highleyman

Long-term AIDS survivor Matt Sharp, left, is a participant in a clinical trial run by Dr. Jay Lalezari.

Yet current antiretroviral drugs cannot completely eliminate the virus; HIV can silently hide in reservoirs such as long-lived memory T-cells and comes roaring back soon after treatment is interrupted. Several changes during the past few years have made discussion of a cure no longer taboo, including greater understanding of how HIV evades the immune system and persists in the body. “We’ve learned so much about the basic biology of HIV that we’re willing to say aloud See page 15 >>


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