Publicacions científiques CSDM 2022

Publicacions científiques 2022

Consorci Sanitari del Maresme. Publicacions de l’any 2022

Biblioteca.

Direcció Acadèmica, Recerca i Innovació Consorci Sanitari del Maresme.

Publicacions Científiques CSDM 2022

Presentació.

Aquest document recull i presenta els articles científics del Consorci Sanitari del Maresme (amb almenys un autor amb filiació CSDM) indexats al llarg de l’any 2022 en almenys alguna de les següents bases de dades: MEDLINE/PubMed/Web of Science (WOS)/Journal Citation Reports (JCR)

Els indicadors bibliomètrics adjudicats a cada article i per Serveis (Factor d’Impacte, Quartil, i Posició de la revista) corresponen al Journal Citation Reports 2021, per la qual cosa s’ha de tenir en compte que són valors aproximats, els valors definitius seran els del JCR 2022 i estaran disponibles el proper mes de juliol de 2023

En aquest document s’inclouen els articles amb etiqueta ahead of print de PubMed encara que siguin posteriorment indexats a MEDLINE durant l’any 2023. Per tant, no s’han inclòs aquells articles ahead of print del 2021 de PubMed que han estat indexats definitivament a MEDLINE durant el 2022 i que ja es van incloure a la llista de l’any passat o anteriors, evitant, d’aquesta manera, duplicitats.

No s’han considerat aquells articles que els autors CSDM consten dins de grups d’investigació (col.laboradors). I tampoc s’han considerat aquells articles indexats però que corresponen a resums/abstracts de congresos.

El document recull també els articles no indexats a cap de les BDD anteriors, així com altres documents (llibres, capítols de llibres, guies, protocols, documents de consens…) publicats durant l’any 2022.

Aquest document recull els articles publicats en el període que va del dia 22 de desembre de 2021 a 22 desembre 2022 En el present document hi han 3 articles amb data 2021 que van ser publicats posteriorment a la data de tancament del document Publicacions Científiques CSDM 2021.

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Fotografia : Dani Olea. Comunicació

Índex

PRESENTACIÓ…………………………………………………………………………………………………………………………..………………………… 2

Anestesiologia– Anesthesiology ……………………………………………………………………….…………………………………….…..….…. 4

Cirurgia General – General Surgery …………………………………………………………………………….…………………………………..…. 5

Cirurgia Ortopèdica i Traumatologia – Orthopaedic Surgery……………………………………………………………….………………. 9

Cirurgia Vascular – Vascular Surgery ……………………………………..………………………………………………………..…………………. 11

Dermatologia - Dermatology …..……...…….…………………………..……………………………………………………………………………… 12

Digestiu – Gastroenterology …..……………………….……………………………………………..……………..……….………………………… 13

Direcció –Management …………………...…….…………………………..……………………………………………………………………………… 16

Farmàcia – Pharmacy ……………………...…….…………………………..……………………………………………………………………………… 16

Hematologia– Hematology ….……………………….……………………………………………..………………….………………………………… 18

Medicina de Família – Family Medicine ………………………….…………………………………………………………………………………. 20

Medicina Física y Rehabilitació – Physical Medicine & Rehabilitation…………….……………………………………..………… 21 Medicina Intensiva – Intensive Care Medicine ……………………………………………………………………………………………….... 23 Medicina Interna – Internal Medicine ……………………………………………………………………….………………………………..…. .. 31

Motilitat Digestiva – Gastrointestinal Motility ……………………………………………………………………………………..………….. 41

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Publicacions Científiques CSDM 2022

ANESTESIOLOGIA – ANESTHESIOLOGY

Nº Articles indexats: 2 Factor Impacte total: 5.721 Factor d’impacte liderat: 0

Ripollés-Melchor J, Sánchez-Santos R, Abad-Motos A, Gimeno-Moro AM, Díez- Remesal Y, Jove-Alborés P, AragóChofre P, Ortiz-Sebastian S, Sánchez-Martín R, Ramírez-Rodríguez JM, Trullenque-Juan R, Valentí-Azcárate V, Ramiro-Ruiz Á, Correa-Chacón OC, Batalla A, Gimeno-Grauwinkel C, Sanahuja-Blasco JM, González-Valverde FM, Galán-Menéndez P, Díez-Zapirain MJ, Vilallonga R, Zorrilla-Vaca A, Pascual-Bellosta AM, Martínez-Ubieto J, Carrascosa-Mirón T, Ruiz-Escobar A, Martín-García-Almenta E, Suárez-de-la-Rica A, Bausili M, Palacios-Cordoba Á, Olvera-García MM, Meza-Vega JA, Sánchez-Pernaute A, Abad-Gurumeta A, Ferrando-Ortola C, MartínVaquerizo B, Torres-Alfonso JR, Aguado-Sánchez S, Sánchez-Cabezudo-Noguera F, García-Erce JA, Aldecoa C;

POWER 3 Study Investigators Group.

Higher Adherence to ERAS Society® Recommendations is Associated with Shorter Hospital Stay Without an Increase in Postoperative Complications or Readmissions in Bariatric Surgery: the Association Between Use of Enhanced Recovery After Surgery Protocols and Postoperative Complications after Bariatric Surgery (POWER 3) Multicenter Observational Study.

Obes Surg. 2022 Apr;32(4):1289-1299. doi: 10.1007/s11695-022-05949-6. Epub 2022 Feb 10. PMID: 35143011

Abstract

Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCVRNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018.

Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation.

Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001).

Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population.

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Publicacions Científiques CSDM 2022

Pre-operative prevalence of asymptomatic carriers of COVID-19 in hospitals in Catalonia during the first wave after the resumption of surgical activity.

Cir Esp (Engl Ed). 2022 Jun;100(6):352-358. doi: 10.1016/j.cireng.2022.05.013. Epub 2022 May 14. PMID: 35580757; PMCID: PMC9107105.

Abstract

Introduction: The COVID-19 pandemic led to the cancellation of non-essential surgical procedures in March 2020. With the resumption of surgical activity, patients undergoing surgery were one of the first population groups to be systematically tested for PCR. The aim of this study was to determine the prevalence of asymptomatic SARS-CoV-2 carriers after the resumption of non-essential surgical activity.

Methods: Retrospective multicenter observational study of patients scheduled for surgery or undergoing emergency surgery in Catalonia between 20 April and 31 May 2020. The microbiological results of preoperative PCR tests and clinical records were reviewed, and an epidemiological survey was conducted on patients with positive PCR for SARS-CoV-2.

Results: A total of 10,838 patients scheduled for surgery or who underwent emergency surgery were screened for COVID-19. One hundred and eighteen patients (1.09%) were positive for SARS-CoV-2 in the 72 h prior to surgery. The prevalence of asymptomatic carriers was 0.7% (IC95%: 0.6%-0.9%). The first week of the study presented the highest prevalence of asymptomatic carriers [1.9% (CI95%:1.1%-3.2%)].

Conclusions: The low levels of asymptomatic carriers of COVID-19 infection obtained in the surgical population of hospitals in Catalonia after the resumption of surgical activity, shows that most patients were able to undergo surgical procedures without the risks of COVID-19 associated complications in the perioperative period.

Cir Esp (Engl Ed). 2022 Jun;100(6):336-344. doi: 10.1016/j.cireng.2022.05.023. Epub 2022 May 23. PMID: 35618203.

Abstract

Background: Incisional hernia (HI), in open and laparoscopic surgery, is a very frequent complication. HI located in the umbilical region are called M3. The main aim of this study is to compare HI produced by the placement of an umbilical laparoscopic trocar (M3T) with those located in M3 in open surgery (M3O) in terms of basal characteristics, complications and recurrences; and secondarily the identification of risk factors.

Method: Cross-sectional observational study based on the national prospective registry EVEREG during the period of July 2012-June 2018. The main variables were recurrences and postoperative complications. Both groups (M3T and M3O) were compared. Multiple logistic regression was performed to identify the risk factors of the entire cohort.

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Publicacions Científiques CSDM 2022

Results: 882 had a follow-up time longer than 12 months. M3O group presented superior ASA-Class, more complex HI and previous repair. It also presented a higher recurrence rate at 12 and 24 months (8.6% vs. 2.5%; P < 0,0001 and 9.3% vs. 2.9%; P < 0.0001) and higher postoperative complications rate (21.9% vs. 14.6 %; P = 0.02). Previous repair, intervention length and associated procedures requirement were identified as risk factors for postoperative complications. Absence of a specialist present during surgery, previous repair, and the absence of complications were identified as risk factors for recurrence. In the PSM analysis no differences were detected in of complications and recurrences.

Conclusions: HI M3O is more complex than M3T. The complexity is not related to the origin of the hernia but to its characteristics and those of the patient.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.242 Quartil: 3 Categoria: Surgery Posició: 123/213

Morales-García

Consensus of the ambulatory surgery commite section of the

Surgeons

role of ambulatory surgery in the SARS-CoV-2 pandemic.

Cir Esp (Engl Ed). 2022 Mar;100(3):115-124. doi: 10.1016/j.cireng.2022.02.014. Epub 2022 Feb 24. PMID: 35249855; PMCID: PMC8866086

Abstract

The current situation of the SARS-CoV-2 pandemic has paralyzed non-urgent and/or oncological surgery in many hospitals in our country with what it means for the health of citizens who are awaiting a surgical procedure. Outpatient Surgery can afford more than 85% of the surgical procedures that are performed in a surgical department and is presented as a feasible and safe alternative at the present time since it does not require admission and decreases clearly the risk of infection. In addition, it is the tool that should be generalized to solve the accumulation of patients on the waiting list that the pandemic is generating, so it seems appropriate that the Ambulatory Surgery section of the Spanish Association of Surgeons present a series of recommendations for the implementation of outpatient surgery in these exceptional circumstances that we have to live.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.242 Quartil: 3 Categoria: Surgery Posició: 123/213

Lopez Gordo S, Bettonica C, Miró M, Estremiana F, Aranda H, Farran L. Gastric and Small Intestine Gist: Results of 156 Cases in 20 Years.

J Gastrointest Cancer. 2022 Jun;53(2):451-459. doi: 10.1007/s12029-021-00641-x. Epub 2021 Apr 19. PMID: 33871798

Abstract

Purpose: Gastric and small intestine are the most common gastrointestinal stromal tumors (GISTs). There are few studies of patients who underwent surgical treatment with disparate findings. We aimed to evaluate the differences between groups and the risk factors for recurrence and mortality.

Methods: A retrospective study of 96 gastric and 60 small intestine GIST was performed between 1995 and 2015. Both groups were compared in terms of clinicopathologic features, morbidity, recurrence, and mortality. Statistical analysis was performed with SPSS®.

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D, Docobo-Durantez F, Capitán Vallvey JM, Suarez-Grau JM, Campo-Cimarras ME, GonzálezVinagre S, Hidalgo-Grau LA, Puigcercos-Fusté JM, Zaragoza-Fernández C, Valera-Sánchez Z, Vega-Ruiz V; Surgery-AEC-COVID-19 workgroup.

SpanishAssociation of

on the

Publicacions Científiques CSDM 2022

Results: Eighty-one gastric GISTs and 56 small intestine GISTs underwent surgical treatment. Gastrointestinal bleeding was the most common cause of emergency surgery being more frequent in gastric GIST (P = 0.009); however, emergency surgery was indicated more frequently in the small intestinal GIST (P = 0.004) and was mostly due to perforation (P = 0.009). With a median follow-up of 66.9 (39.7-94.8) months, 28 (20.4%) patients had recurrence. A mitotic index > 5 (P ≤ 0.001) and the intestinal location (P = 0.012) were significantly associated to recurrence. Tumor size > 15 cm (P = 0.001) and an age of ≥ 75 years (P = 0.014) were associated to mortality. On univariate analysis, higher mean values of Ki-67 were associated to higher mortality (P = 0.0032). Small intestine GIST presented lower disease-free survival (DFS) than that of gastric GIST (65.7% vs 90.8%) with P = 0.003. The overall survival (OS) of gastric and small intestine GIST was 74.7% and 71.6%, respectively (P = 0.68).

Conclusion: Small intestine GIST received emergency surgery more frequently showing lower DFS and same OS than that of gastric GIST. We found that Ki-67 could be a prognostic factor. Further studies are necessary to assess whether Ki-67 is a prognostic risk factor for GISTs

Indexat a: MEDLINE/WOS

20:S0748-7983(22)00658-8. doi: 10.1016/j.ejso.2022.09.007. Epub ahead of print. PMID: 36163062

Abstract

Patient Blood Management (PBM) programs have probed to reduce blood transfusions and postoperative complications following gastric cancer resection, but evidence on their economic benefit is scarce. A recent prospective interventional study of our group described a reduction in transfusions, infectious complications and length of stay after implementation of a multicenter PBM program in patients undergoing elective gastric cancer resection with curative intent. The aim of the present study was to analyze the economic impact associated with these clinical benefits. The mean [and 95% CI] of total healthcare cost per patient was lower (1955 [-3764, -119] €) after the PBM program implementation. The main drivers of this reduction were the hospital stay (-1847 [-3161, -553] €), blood transfusions (-100 [-145, -56] €), and post-operative complications (162 [-718, 411] €). Total societal cost was reduced by -2243 [-4244, -210] € per patient. These findings highlight the potential economic benefit of PBM strategies.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.037 Quartil: 1 Categoria: Surgery Posició: 41/213

Acute foreign body appendicitis. Cir Esp (Engl Ed). 2022 Sep 12:S2173-5077(22)00351-9. mdoi: 10.1016/j.cireng.2022.09.011. Epub ahead of print. PMID: 36100048

Abstract

Acute foreign body appendicitis is an exceptional entity caused by obstruction of the appendiceal lumen by an object foreign to the digestive tract. We present the case of a 41-year-old man who underwent surgery for a diagnosis of acute appendicitis after consulting due to typical clinical symptoms of 48-h onset. Surgery revealed

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Jericó C, Puértolas N, Osorio J, Miranda C, Santamaría M, Artigau E, Galofré G, Garsot E, Luna A, Aldeano A, Olona C, Pulido L, Pera M; Spanish EURECCA Esophagogastric Cancer Group. Cost analysis of a patient blood management program for patients undergoing gastric cancer surgery. Eur J Surg Oncol. 2022 Sep

Vila Tura M, Perdomo Valles MD, Clos Ferrero P, Ferré Forcadell T.

Publicacions Científiques CSDM 2022

acute phlegmonous appendicitis and section of the appendiceal base revealed that the lumen of the appendix was occupied by a dental prosthesis. On further questioning, the patient reported the accidental ingestion of the implant four days before the onset of symptoms.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.242 Quartil: 3 Categoria: Surgery Posició: 123/213

Osorio J, Madrazo Z, Videla S, Sainz B, Rodríguez-Gonzalez A, Campos A, Santamaria M, Pelegrina A, GonzalezSerrano C, Aldeano A, Sarriugarte A, Gómez- Díaz CJ, Ruiz-Luna D, García-Ruiz-de-Gordejuela A, Gomez-Gavara C, Gil-Barrionuevo M, Vila M, Clavell A, Campillo B, Millan L, Olona C, Sanchez-Cordero S, Medrano R, LopezArevalo CA, Pérez-Romero N, Artigau E, Calle M, Echenagusia V, Otero A, Tebe C, Pallares N, Biondo S, Valderas JM; COVID-CIR Collaborative Group.

Use of failure-to-rescue after emergency surgery as a dynamic indicator of hospital resilience during the COVID-19 pandemic. A multicenter retrospective propensity score-matched cohort study.

Int J Surg. 2022 Oct;106:106890. doi:10.1016/j.ijsu.2022.106890. Epub 2022 Sep 9. PMID: 36089261; PMCID: PMC9458615

Abstract

Background: Surgical failure-to-rescue (FTR, death rate following complications) is a reliable cross-sectional quality of care marker, but has not been evaluated dynamically. We aimed to study changes in FTR following emergency surgery during the COVID-19 pandemic.

Material and methods: Matched cohort study including all COVID-19-non-infected adult patients undergoing emergency general surgery in 25 Spanish hospitals during COVID-19 pandemic peak (March-April 2020), nonpeak (May-June 2020), and 2019 control periods. A propensity score-matched comparative analysis was conducted using a logistic regression model, in which period was regressed on observed baseline characteristics. Subsequently, a mixed effects logistic regression model was constructed for each variable of interest. Main variable was FTR. Secondary variables were post-operative complications, readmissions, reinterventions, and length of stay.

Results: 5003 patients were included (948, 1108, and 2947 in the pandemic peak, non-peak, and control periods), with comparable clinical characteristics, prognostic scores, complications, reintervention, rehospitalization rates, and length of stay across periods. FTR was greater during the pandemic peak than during non-peak and pre-pandemic periods (22.5% vs. 17.2% and 12.7%), being this difference confirmed in adjusted analysis (odds ratio [OR] 2.13, 95% confidence interval [95% CI] 1.27-3.66). There was sensible inter-hospital variability in FTR changes during the pandemic peak (median FTR change +8.77%, IQR 0-29.17%) not observed during the pandemic non-peak period (median FTR change 0%, IQR -6.01-6.72%). Greater FTR increase was associated with higher COVID-19 incidence (OR 2.31, 95% CI 1.31-4.16) and some hospital characteristics, including tertiary level (OR 3.07, 95% CI 1.27-8.00), medium-volume (OR 2.79, 95% CI 1.14-7.34), and high basaladjusted complication risk (OR 2.21, 95% CI 1.07-4.72).

Conclusion: FTR following emergency surgery experienced a heterogeneous increase during different periods of the COVID-19 pandemic, suggesting it to behave as an indicator of hospital resilience. FTR monitoring could facilitate identification of centres in special needs during ongoing health care challenges

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 13.400 Quartil: 1 Decil: 1 Categoria: Srugery

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Posició: 5/213

Publicacions Científiques CSDM 2022

Hidalgo L.

Cirugía Mayor Ambulatoria en España. ¿Dónde estamos?

Cir May Amb 2021, 26 (4): 188-189

Abstract

Muchos profesionales del mundo de la sanidad estamos convencidos de que el futuro de la asistencia hospitalaria pasa necesariamente por una apuesta decidida por la ambulatorización. En efecto, recursos asistenciales como son el Hospital de Día, el Hospital a Domicilio y la Cirugía Ambulatoria serán esenciales para conseguir que nuestro sistema sanitario sea viable y sostenible. Es evidente que los recursos mencionados consiguen un producto sanitario más eficiente, pero no podemos olvidar que la eficiencia se basa en combinar el mantenimiento de la calidad asistencial con el ahorro de costes, y uno de los puntales de la calidad asistencial es la seguridad de los pacientes.

Según las cifras publicadas por el Ministerio de Sanidad y Consumo, que corresponden al año 2019, la Cirugía Mayor Ambulatoria (CMA) representa el 47,2 % del total de la actividad de cirugía mayor en España (1). De acuerdo con los datos correspondientes a 2013, la CMA representaba ese año el 43,04 % de dicha actividad. Por lo tanto, el incremento que hemos conseguido en ese periodo de 4 años es algo superior al 4 %. Esta cifra, siendo valorable tanto de forma absoluta como en aumento porcentual, queda lejos de las que aportan otros países, por encima del 60 %, y en algunos casos cercanas al 80 %.

Necesitamos incrementar la ambulatorización de la cirugía en nuestro país y acercarnos a las cifras que han conseguido otros países. Este incremento pasa por aumentar nuestra cartera de servicios (incluyendo nuevos procedimientos) y también por aumentar los índices de substitución de procedimientos consolidados en CMA. Pero como se comentaba anteriormente, para que ambas circunstancias se den, es esencial tener en cuenta la calidad asistencial que ofrezcamos junto a la seguridad de los pacientes.

loads developed by

across the elbow joint.

model. J Biomech. 2022 Oct 22;145:111356. doi: 10.1016/j.jbiomech.2022.111356. Epub ahead of print. PMID: 36403528

Abstract

The radio-humeral joint has traditionally been believed to support most of the loads transmitted through the elbow. Load transfer through the elbow has been a controversial issue since the publication of the first biomechanical studies on the subject, most of which were based on extrinsic forces acting on the extended joint. The present study analyzes load distribution across the six different compartments in the elbow while the joint is flexed, as well as the intrinsic forces generated in the epicondylar and epitrochlear muscles. Ten cadaveric elbows were positioned at 90° of flexion, forearm in a neutral position and wrist at 0°. Tekscan sensors were used for measuring intraarticular pressures. Forces generated by epitrochlear muscles results in a series of loads that affect mainly the anteromedial facet (40%), followed by the posterolateral facet (34%) of the ulnohumeral joint, with the flexor carpi ulnaris generating the heaviest loads (43% on the anteromedial and 38% on the posterolateral facets). Conversely, the forces generated by the epicondylar muscles, similar in behavior but with an opposite direction, convey heavier loads to the elbow's anterolateral facet (45%), followed by the

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Pérez-Abad M, Noriego Muñoz D, Ferreres Claramunt Á, Del Valle Jou M, Rodríguez-Baeza A.

epicondylar and epitrochlear muscles

A dynamic simulated

Publicacions Científiques CSDM 2022

radiohumeral joint (26%) with the extensor carpi ulnaris generating the heaviest loads (54% on the anterolateral facet and 17% on the radiohumeral joint). Our results indicate that the elbow joint exhibits a characteristic load distribution pattern that depends on the muscles, as intrinsic forces are generated by the epicondylar and epitrochlear muscles. The anterior portion of the ulnohumeral joint is the area bearing the heaviest loads.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.789 Quartil: 3 Categoria: Biophysics Posició: 45/72

Abstract

Background: Maceira’s triple cut modified Weil osteotomy is indicated in the manage-ment of propulsive metatarsalgia. In this surgical procedure, the osteotomy will be usually stabilized with fixation. Our study is aimed at comparing the effectiveness of Maceira’s triple cut modified Weil osteotomy stabilized with fixation and without fixation.

Methods: A retrospective individual cohort study was conducted from the data retrieved from 44 feet included of 40 patients, presented with propulsive metatarsal-gia, who underwent “Maceira’s triple cut modification of Weil osteotomy”. In 29 feet, 57 osteotomies were performed without fixation, while in 15 feet, 56 osteotomies were performed along with the fixation. The mean follow-up period was 13.1 months and 12.4 months, respectively, in non-fixed and fixed groups. The patients were evaluated using AOFAS LIMS scale.

Results: In fixation group, the pre-operative mean scores were 42.47 ± 12.72 and the post-operative mean score was 70.8 ± 25.14, where as in non-fixation group preoperative mean score was 43.79 ± 13.20 and post-operative mean score was 81.59 ± 14.19. In both the groups there was improvement in the mean scores, which was statistically significant. But when compared amongst the fixation and nonfixation of osteotomy groups, there was no difference that was statistically significant (p > 0.01).

Conclusions: Maceira’s triple cut modification of Weil osteotomy with or without fixation yields equal and effective results in patients with propulsive (3rd rocker) metatarsalgia.

Acta Scientific

Abstract

5.9 (2022): 59-62.

Several anesthetic techniques are used in foot and ankle surgery, WALANT technique is one of them that has several advantages: fast procedure, no ischemia or tourniquet needed, dynamic evaluation. Less preoperative test are needed and the total cost is reduced. It has very successful proven in upper extremity.

We would like to evaluate the patient satisfaction of the WALANT technique in forefoot surgery. 21 patients are included in the study. 66% of the patients had no pain and 19% had minimal pain during the surgery. 85% of the cases recommended or strongly recommended this technique for the forefoot surgery. Our results indicate that WALANT surgery is a safe with very good satisfaction indicators for the patients

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Krishnaprasad PR, Lucar-López G, Guevara-Noriega KA, Lakshmisha Rao Y, Murlimanju BV, Ballal A, BallesterAlomar M.

Propulsive Metatarsalgia: a Comparative Study of Maceira’s Osteotomy with and without Fixation. Muscles, Ligaments and Tendons Journal. 2022 Jan 1;12(1):24-34. https://doi.org/10.32098/mltj.01.2022.04.

Indexat a: WOS

Lucar-López G, Paz Ramirez J, Gomez Blanco FM, Ballester-Alomar M, Guevara-Noriega, KA, Villamizar Avendaño MA.

Patient Satisfaction in Forefoot Surgery Using Walant Technique

Orthopaedics

Publicacions Científiques CSDM 2022

Description

Abstract

2022;36(1):54-58

Most of the time forefoot surgery requires the use of a tourniquet, and therefore, the surgery is usually performed with either a popliteal block or an ankle block. Surgical departments have traditionally relied on an anesthesiologist to perform these procedures. The elective nature of the forefoot surgery and the lack of surgical anaesthetists due to the COVID-19 pandemic have become mandatory to find alternatives to continue performing these surgeries in order to avoid an increase of waiting lists. The foot and ankle wide-awake local anaesthesia with no tourniquet (WALANT) technique is an adaptation from the one used for hand surgery. This technique requires no sedation, no regional or general anaesthesia, and the patient is fully conscious during the operation. WALANT technique consists of administration of lidocaine and epinephrine for local anaesthesia and vasoconstriction. This technique allows the surgeon to perform the surgery with the patient fully awake and without a tourniquet. In addition, this gives the advantage to perform an intraoperative assessment of function. WALANT for foot and ankle surgery is a suitable, safe, and cheap technique. Taking into consideration the lack of anaesthetists, operating rooms, and hospital resources observed during SARS-CoV-2 epidemic, this technique represents an acceptable alternative to consider in order to be able to continue performing selected cases of foot and ankle surgery.

CIRURGIA VASCULAR – VASCULAR SURGERY

Nº Articles indexats: 1 Factor Impacte total: 3.007 Factor d’impacte liderat: 0 Alzamora MT, Forés R, Serra N, Martinez E, Pera G, Seda G,

P.

Supervised physical activity in patients with symptomatic peripheral arterial disease: protocol for a randomized clinical trial (ARTPERfit Study).

BMJ Open. 2022 Apr 27;12(4):e054352. doi: 10.1136/bmjopen-2021-054352. PMID: 35477870; PMCID: PMC9047770.

Abstract

Introduction: Peripheral arterial disease (PAD) is a marker of cardiovascular morbidity, causing disability, loss of mobility and poor quality of life, manifesting clinically in the form of intermittent claudication (IC). Physical exercise increases the distance walked and improves quality of life. The aim of our study will be increased walking distance prolonging the time of onset of pain in patients with symptomatic PAD (IC).

Methods and analysis: This study will be performed in Mataró Hospital's vascular surgery service and School of Health Sciences, TecnoCampus. This population comes from 15 primary healthcare centres ofNorth Barcelona, Spain (450 000 inhabitants). This study will be a four-group parallel, longitudinal, randomised controlled trial, blind to analysis.The main primary outcome of this study will be the improvement in pain-free walking distance. Others primary objectives are and improvement in functional status, quality of life and Ankle-Brachial Index (ABI). Secondary outcomes will be the analysis of cardiorespiratory fitness, evaluation of muscle fitness, determine the maintenance of primary objectives at 6 and 12 months.We will be included 124 patients (31 per group). The changes of the outcome (Barthel, SF-12, VascQOL-6, ABI) of the three intervention groups vs the control group at 3, 6 and 12 months will be compared, both continuously (linear regression) and categorically (logistic regression). A person who has not performed at least 75% of the training will be considered to have not completed the intervention.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Lucar López G, Guevara-Noriega KA, Villamizar Avendaño MA, Sierra Pereira AA, Ballester-Alomar M.

of WALANT technique in forefoot surgery in time of COVID-19. Revista del Pie y Tobillo.

Lopez Palencia J, Gomis M, Heras Tébar A, Valverde M, Garnacho MV, Torán

Publicacions Científiques CSDM 2022

Ethics and dissemination: The study will be conducted according to the Declaration of Helsinki . It was approved by the Ethics Committee of the Research Institute Primary Health IDIAP Jordi Gol (20/035 P),Barcelona 6 October 2020. Informed consent will be obtained from all patients before the start of the study. We will disseminate results through academic papers and conference presentations.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 3.007 Quartil: 2 Categoria: Medicine, General & Internal Posició: 86/172

DERMATOLOGIA – DERMATOLOGY

Nº Articles indexats: 1 Factor Impacte total: 2.481 Factor d’impacte liderat: 0

Australas J Dermatol. 2022 Feb;63(1):53-61. doi: 10.1111/ajd.13781. Epub 2021 Dec 27. PMID: 34958128. Abstract

Background: Clinical and dermoscopic recognition of seborrheic keratoses (SKs) is often straightforward, and biopsy might not be required. However, inflamed SKs (iSKs) can pose a diagnostic challenge. Dermoscopic features of iSKs have not yet been evaluated to date.

Objectives: To assess the diagnostic ability of a group of dermatologists to diagnose iSKs by dermoscopy. To evaluate the dermoscopic findings of a long series of inflamed seborrheic keratoses.

Methods: Clinical and dermoscopic images of 100 difficult-to-diagnose skin tumours, including 29 iSKs, were presented to 33 clinicians (24 dermatologists and 9 dermatology residents), who were blinded to the diagnosis. The dermoscopic features of a series of 219 iSKs were retrospectively analysed.

Results: iSKs were correctly identified in a 37.6% of cases. Classic dermoscopic criteria were present in only 47% of iSKs. The most frequent dermoscopic feature in iSKs was the presence of vascularization (91.3%), but only a 44.5% showed predominance of hairpin vessels. A bluish hue was observed in 18.3% of lesions. Seven dermoscopic patterns were identified, based on the dermoscopic similarity to other tumours: seborrheic keratosis-like (28.8%); squamous cell carcinoma-like (25.6%); melanoma-like (17.8%); keratoacanthoma-like (6.8%); basal cell carcinoma-like (5.9%); verruca vulgaris-like (5.9%); nevus-like (2.3%).

Conclusions: The diagnosis of iSKs can be challenging even with dermoscopy. They may behave as authentic mimics of other cutaneous tumours, including squamous cell carcinoma or melanoma. For this reason, histopathological examination should be mandatory in these cases.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Álvarez-Salafranca M, Gómez-Martín I, Bañuls J, Serrano P, Medina C, Llambrich A, Pizarro Á, Ara M, Zaballos P. Dermoscopy of inflamed seborrheic keratosis: A great mimic of malignancy.

Publicacions Científiques CSDM 2022

DIGESTIU - GASTROENTEROLOGY

Nº Articles indexats: 4 Factor Impacte total: 22.7 Factor d’impacte liderat: 0

Navarro P, Laserna-Mendieta EJ, Casabona S, Savarino E, Pérez-Fernández MT, Ghisa M, Pérez-Martínez I, Guagnozzi D, Perelló A, Guardiola-Arévalo A, Racca F, Betoré E, Blas-Jhon L, Krarup AL, Martín-Domínguez V, Maniero D, Suárez A, Llerena-Castro R, de la Peña-Negro L, Navacerrada AG, Pellegatta G, Alcedo J, de Hurtado Mendoza-Guena L, Feo-Ortega S, Barrio J, Gutiérrez-Junquera C, Fernández-Fernández S, De la Riva S, E Navés J, Carrión S, Ciriza de Los Ríos C, García-Morales N, Rodríguez-Oballe JA, Dainese R, Rodríguez-Sánchez A, Masiques- Mas ML, Palomeque MT, Santander C, Tamarit-Sebastián S, Arias Á, Lucendo AJ. Accurate and timely diagnosis of Eosinophilic Esophagitis improves over time in Europe. An analysis of the EoE CONNECT Registry.

United European Gastroenterol J. 2022 Jun;10(5):507-517. doi: 10.1002/ueg2.12240. Epub 2022 May 16. PMID:35578565; PMCID: PMC9189464

Abstract

Background: Poor adherence to clinical practice guidelines for eosinophilic esophagitis (EoE) has been described and the diagnostic delay of the disease continues to be unacceptable in many settings.

Objective: To analyze the impact of improved knowledge provided by the successive international clinical practice guidelines on reducing diagnostic delay and improving the diagnostic process for European patients with EoE.

Methods: Cross-sectional analysis of the EoE CONNECT registry based on clinical practice. Time periods defined by the publication dates of four major sets of guidelines over 10 years were considered. Patients were grouped per time period according to date of symptom onset.

Results: Data from 1,132 patients was analyzed and median (IQR) diagnostic delay in the whole series was 2.1 (0.7-6.2) years. This gradually decreased over time with subsequent release of new guidelines (p < 0.001), from 12.7 years up to 2007 to 0.7 years after 2017. The proportion of patients with stricturing of mixed phenotypes at the point of EoE diagnosis also decreased over time (41.3% vs. 16%; p < 0.001), as did EREFS scores. The fibrotic sub-score decreased from a median (IQR) of 2 (1-2) to 0 (0-1) when patients whose symptoms started up to 2007 and after 2017 were compared (p < 0.001). In parallel, symptoms measured with the Dysphagia Symptoms Score reduced significantly when patients with symptoms starting before 2007 and after 2012 were compared. A reduction in the number of endoscopies patients underwent before the one that achieved an EoE diagnosis, and the use of allergy testing as part of the diagnostic workout of EoE, also reduced significantly over time (p = 0.010 and p < 0.001, respectively).

Conclusion: The diagnostic work-up of EoE patients improved substantially over time at the European sites contributing to EoE CONNECT, with a dramatic reduction in diagnostic delay.

Indexat a: MEDLINE/WOS/JCR

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Abstract

Background: The growing prevalence of eosinophilic esophagitis (EoE) represents a considerable burden to patients and health care systems. Optimizing cost-effective management and identifying mechanisms for disease onset and progression are required. However, the paucity of large patient cohorts and heterogeneity of practice hinder the defining of optimal management of EoE.

Methods: EoE CONNECT is an ongoing, prospective registry study initiated in 2016 and currently managed by EUREOS, the European Consortium for Eosinophilic Diseases of the Gastrointestinal Tract. Patients are managed and treated by their responsible specialists independently. Data recorded using a web-based system include demographic and clinical variables; patient allergies; environmental, intrapartum, and early life exposures; and family background. Symptoms are structurally assessed at every visit; endoscopic features and histological findings are recorded for each examination. Prospective treatment data are registered sequentially, with new sequences created each time a different treatment (active principle, formulation, or dose) is administered to a patient. EoE CONNECT database is actively monitored to ensure the highest data accuracy and the highest scientific and ethical standards.

Results: EoE CONNECT is currently being conducted at 39 centers in Europe and enrolls patients of all ages with EoE. In its aim to increase knowledge, to date EoE CONNECT has provided evidence on the effectiveness of firstand second-line therapies for EoE in clinical practice, the ability of proton pump inhibitors to induce disease remission, and factors associated with improved response. Drug effects to reverse fibrous remodeling and endoscopic features of fibrosis in EoE have also been assessed.

Conclusion: This prospective registry study will provide important information on the epidemiological and clinical aspects of EoE and evidence as to the real-world and long-term effectiveness and safety of therapy. These data will potentially be a vital benchmark for planning future EoE health care services in Europe.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.802 Quartil: 2 Categoria: Gastroenterology & Hepatology Posició: 39/93

Cárdenas-Jaén K, Sánchez-Luna SA, Vaillo-Rocamora A, Castro-Zocchi MR, Guberna-Blanco L, Useros-Brañas D, Remes-Troche JM, Medina AR, Priego-Parra BA, Velarde-Ruiz Velasco JA, Martínez-Ayala P, Urzúa Á, GuiñezFrancois D, Pawlak KM, Kozłowska-Petriczko K, Gorroño-Zamalloa I, Urteaga-Casares C, Ortiz-Polo I, Antoñana ADV, Lozada-Hernández EE, Obregón-Moreno E, García-Rayado G, DomperArnal MJ, Casas-Deza D, Esteban-Cabello EI, Díaz LA, Riquelme A, Martínez-Lozano H, Navarro-Romero F, Olivas I, Iborra-Muñoz G, Calero-Amaro A, Caravaca-García I, Lacueva-Gómez FJ, Pastor-Mateu R, Lapeña-Muñoz B, Sastre-Lozano V, Pizarro- Vega NM, Melcarne L, Pedrosa-Aragón M, Mira JJ, MStat AM, Carrillo I, de-Madaria E. Gastrointestinal symptoms and complications in patients hospitalized due to COVID-19, an international multicentre prospective cohort study (TIVURON project).

Gastroenterol Hepatol. 2022 Oct 12:S0210-5705(22)00233-3. English, Spanish. doi: 10.1016/j.gastrohep.2022.10.007. Epub ahead of print. PMID: 36243249; PMCID: PMC9557114.

Abstract

Background: retrospective studies suggest that coronavirus disease (COVID-19) commonly involves gastrointestinal (GI) symptoms and complications. Our aims was to prospectively evaluate GI manifestations in patients hospitalized for COVID-19.

Methods: this international multicentre prospective cohort study recruited COVID-19 patients hospitalized at 31 centres in Spain, Mexico, Chile, and Poland, between May-September 2020. Patients were followed-up until 15 days post-discharge and completed comprehensive questionnaires assessing GI symptoms and complications. A descriptive analysis as well as a bivariate and multivariate analysis were performer using binary logistic regression. P<0.05 was considered significant.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Results: eight hundred twenty-nine patients were enrolled; 129 (15.6%) had severe COVID-19, 113 (13.7%) required ICU admission, and 43 (5.2%) died. Upon admission, the most prevalent GI symptoms were anorexia (n=413; 49.8%), diarrhoea (n=327; 39.4%), nausea/vomiting (n=227; 27.4%), and abdominal pain (n=172; 20.7%), which were mild/moderate throughout the disease and resolved during follow-up. One-third of patients exhibited liver injury. Non-severe COVID-19 was associated with ≥2 GI symptoms upon admission (OR 0.679; 95% CI 0.464-0.995; p=0.046) or diarrhoea during hospitalization (OR 0.531; 95% CI 0.328-0.860; p=0.009). Multivariate analysis revealed that worse hospital outcomes were not independently associated with liver injury or GI symptoms.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.867 Quartil: 2 Categoria: Gastroenterology & Hepatology Posició: 29/93

Laserna-Mendieta EJ, Navarro P, Casabona-Francés S, Savarino EV, Pérez- Martínez I, Guagnozzi D, Barrio J, Perello A, Guardiola-Arévalo A, Betoré-Glaria ME, Blas-Jhon L, Racca F, Krarup AL, Gutiérrez-Junquera C, Fernández-Fernández S, la Riva S, Naves JE, Carrión S, García-Morales N, Roales V, Rodríguez-Oballe JA, Dainese R, Rodríguez-Sánchez A, Masiques-Mas ML, Feo-Ortega S, Ghisa M, Maniero D, Suarez A, Llerena-Castro R, GilSimón P, Peña-Negro L, Granja- Navacerrada A, Alcedo J, Hurtado de Mendoza-Guena L, Pellegatta G, PérezFernández MT, Santander C, Tamarit-Sebastián S, Arias Á, Lucendo AJ; EUREOS EoE CONNECT Research group. Differences between childhood- and adulthood-onset eosinophilic esophagitis: An analysis from the EoE connect registry.

Dig Liver Dis. 2022 Oct 21:S1590-8658(22)00728-9. doi: 10.1016/j.dld.2022.09.020. Epub ahead of print. PMID: 36280437

Abstract

Background: Direct comparisons of childhood- and adulthood-onset eosinophilic esophagitis (EoE) are scarce.

Aim: To compare disease characteristics, endoscopic and histological features, allergic concomitances and therapeutic choices across ages.

Methods: Cross-sectional analysis of the EoE CONNECT registry.

Results: The adulthood-onset cohort (those diagnosed at ≥18y) comprised 1044 patients and the childhoodonset cohort (patients diagnosed at <18 y), 254. Vomiting, nausea, chest and abdominal pain, weight loss, slow eating and food aversion were significantly more frequent in children; dysphagia, food bolus impaction and heartburn predominated in adults. A family history of EoE was present in 16% of pediatric and 8.2% of adult patients (p<0.001). Concomitant atopic diseases did not vary across ages. Median±IQR diagnostic delay (years) from symptom onset was higher in adults (2.7 ± 6.1) than in children (1 ± 2.1; p<0.001). Esophageal strictures and rings predominated in adults (p<0.001), who underwent esophageal dilation more commonly (p = 0.011). Inflammatory EoE phenotypes were more common in children (p = 0.001), who also presented higher eosinophil counts in biopsies (p = 0.015) and EREFS scores (p = 0.017). Despite PPI predominating as initial therapy in all cohorts, dietary therapy and swallowed topical corticosteroids were more frequently prescribed in children (p<0.001).

Conclusions: Childhood-onset EoE has differential characteristics compared with adulthood-onset, but similar response to treatment.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.165 Quartil: 2 Categoria: Gastroenterology & Hepatology

Posició: 35/93

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

DIRECCIÓ – MANAGEMENT

Nº Articles indexats: 1 Factor Impacte total: 0 Factor d’impacte mig per article: 0

Ibáñez-Romaguera JM, Lavado-Cuevas Á, Camacho-Del-Valle J, Valls-Soler J.

Visual analytics: A key decision support tool in the COVID-19 pandemic management at the hospital.

J Healthc Qual Res. 2022 Mar 10:S2603-6479(22)00022-7. doi: 10.1016/j.jhqr.2022.02.007. Epub ahead of print. PMID: 35534423; PMCID: PMC8907016

Abstract

In every healthcare center a huge amount of data are generated, usually computed-recorded data through different coexisting applications. Any data hosted in the hospital information system (HIS) can be extracted, processed and related to each hospitalized patient, either demographic data, a vital sign as the cardiac frequency or temperature, a laboratory value, a medical treatment (for instance antimicrobial therapy), the presence of multi-resistant bacteria and the need of isolation, or different scales of severity or complexity (NEWS, Barthel, EVA, etc.) and it's possible to create different access profiles for the different healthcare professionals (doctors, nurses) and also for administration or facility staff. The cost of its process could be very high if there are no specific objectives addressed to management decisions. Therefore, any management support tool must be efficient, effective, friendly and easy to use for the professionals, and would allow as well an easy interaction with the hospital information system (HIS)...

Indexat a: MEDLINE/WOS

FARMÀCIA - PHARMACY

from total parenteral nutrition to enteral nutrition in critically ill patients In Spain: A national survey.

Med Intensiva (Engl Ed). 2022 Jun 24:S2173-5727(22)00117-5. doi: 10.1016/j.medine.2022.06.003. Epub ahead of print. PMID: 35760732

Abstract

The administration of parenteral nutrition to critically ill patients is indicated in cases of intestinal failure that prevents the administration of enteral nutrition (EN) or in situations that condition poor supply1,2. Despite the factthat few studies have been conducted in critically ill patients, it is assumed that bowel rest associated with the exclusive use of total parenteral nutrition (TPN) damages the structure and functions of the intestinal mucosa3 5. In this context, tolerance at the beginning of enteral support could be influenced by these anatomical and functional changes. The clinical implications of these alterations have not been studied thoroughly and are barely mentioned in the clinical practice guidelines and the medical literature available. At this point, the incidence rate of complications during transition from total parenteral nutrition to enteral nutrition (TPN-to-EN) or whether it is possible to impact through clinical practice the tolerance of rebooting EN remains unknown. The objective of our study is to know the routine clinical practice in the management of TPN-to-EN in critically ill patients at the intensive care unit (ICU) setting

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Pérez-Cordón L, Yébenes JC, Martínez de Lagrán I, Campins L Transition

Publicacions Científiques CSDM 2022

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.799 Quartil: 3 Categoria: Critical Care medicine Posició: 24/35

Pérez-Cordón L, Sánchez A, Marin S, Force L, Serra-Prat M, Palomera E, Campins L. Real-world effectiveness and durability of dual antiretroviral therapy in HIV-infected patients.

Eur J Hosp Pharm. 2022 Jul 26:ejhpharm-2022-003277. doi: 10.1136/ejhpharm-2022-003277. Epub ahead of print. PMID: 35882532

Abstract

Background and objectives: While randomised controlled trials in HIV-infected patients have shown that certain dual antiretroviral therapy (DAT) regimens are non-inferior in terms of efficacy compared with classical tripledrug regimens, few real clinical experiences have been described. The aim of the study was to investigate, in real clinical practice, DAT effectiveness, durability, and risk factors for treatment discontinuation.

Methods: This was a prospective cohort study that included HIV-infected patients treated with DAT (20152020). DAT was considered effective when patients achieved or maintained virological suppression and was assessed at 24 and 48 weeks. DAT durability was evaluated using the Kaplan-Meier method. Adherence and treatment cost were compared with patients' previous antiretroviral regimens.

Results: 51 patients were included, 27.5% with HIV-1 RNA ≥50 copies/mL at baseline, treated with a wide range of dual combinations. At 48 weeks follow-up, 83.8% and 50.0% of patients who started DAT with HIV-1 RNA <50 copies/mL and ≥50 copies/mL, respectively, were suppressed. 39 out of 51 patients (76.5%) maintained DAT for a mean treatment duration of 40.5±14.8 weeks. Full adherence was observed in 78.4% of patients compared with 70.2% in the previous regimen. Mean daily cost was €18.6±4.3 compared with €16.1±7.9 in the previous regimen (p=0.008).

Conclusion: DAT effectiveness and durability were higher in patients who were virologically suppressed at baseline. DAT is a possible alternative for virologically non-suppressed patients who cannot be treated with a triple-drug regimen.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.530 Quartil: 3 Categoria: Pharmacology & Pharmacy Posició: 205/279

Nutr Hosp. 2022 Feb 9;39(1):171-201. Spanish. doi: 10.20960/nh.03736. PMID: 345380582.

Abstract

Introduction and objective: in recent years, the number of oral antineoplastic and immunomodulating drugs in oncohematology has increased enormously. Often, these drugs must be administered to patients with enteral tube feeding or swallowing disorders, which causes safety problems when handling these drugs (many of them are classified as hazardous drugs). In addition, it is important to note that the administration of these drugs can also interact with enteral nutrition (EN). The objective of this study was to review and update the recommendations for the administration and handling of oral antineoplastic and immunomodulating drugs.

Methods: a Working Group made up of pharmacists from the Pharmacy Group of The Spanish Society of Clinical Nutrition and Metabolism (SENPE) and the Clinical Nutrition Group of The Spanish Society of Hospital Pharmacy (SEFH) was created. A bibliographic review was carried out between 2015 and 2020 on the administration and handling of oral antineoplastic and immunomodulating drugs in oncohematology. The information about

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Crespo Martínez CL, Romero Jiménez RM, Vázquez-López C, Pérez-Cordón L, Vallinas Hidalgo S, Bravo José P. Recomendaciones para la administración de antineoplásicos e inmunomoduladores orales por sonda enteral en oncohematología.

Publicacions Científiques CSDM 2022

pharmaceutical specialties, dosage, presentation, brand names, instructions for oral or enteral tube administration, interactions with EN, precautions, and remarks for handling and administration was analyzed. Results: a total of 77 active principles and 84 pharmaceutical forms were included. Recommendations and instructions for oral, nasogastric tube, and gastrostomy administration, handling of the antineoplastic and immunomodulating drugs, and interactions with EN were described. Conclusions: the handling and administration information about the oral antineoplastic and immunomodulating drugs currently used in oncohematology for people with enteral accesses or swallowing disorders is limited. It is important to perform post-marketing studies to ensure a safe and effective administration of these drugs.

HEMATOLOGIA

HEMATOLOGY

New Mutations in <i>HFE2</i> and <i>TFR2</i> Genes Causing Non <i>HFE</i>-Related Hereditary Hemochromatosis Genes (Basel). 2021 Dec 13;12(12):1980. doi: 10.3390/genes12121980. PMID: 34946929; PMCID: PMC8702017

Abstract

Hereditary hemochromatosis (HH) is an iron metabolism disease clinically characterized by excessive iron deposition in parenchymal organs such as liver, heart, pancreas, and joints. It is caused by mutations in at least five different genes. HFE hemochromatosis is the most common type of hemochromatosis, while non-HFE related hemochromatosis are rare cases. Here, we describe six new patients of non-HFE related HH from five different families. Two families (Family 1 and 2) have novel nonsense mutations in the HFE2 gene have novel nonsense mutations (p.Arg63Ter and Asp36ThrfsTer96). Three families have mutations in the TFR2 gene, one case has one previously unreported mutation (Family A-p.Asp680Tyr) and two cases have known pathogenic mutations (Family B and D-p.Trp781Ter and p.Gln672Ter respectively). Clinical, biochemical, and genetic data are discussed in all these cases. These rare cases of non-HFE related hereditary hemochromatosis highlight the importance of an earlier molecular diagnosis in a specialized center to prevent serious clinical complications.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Aims: We set up a prospective protocol with a 10-color tube and acquisition of 500.000 leukocytes on a Nav flow cytometer for evaluation of BMI in FL by FC. Materials and methods: FC was compared with a combination of histopathology and IGH gene rearrangement, which were considered the gold standard. We also compared BMI by FC with PET. Results: Fifty-two patients were included (median 67 years, 54% female). BMI by FC was seen in 35 (67%), with a median involvement of 1.2% (interquartile range: 0.3%-7%) of leukocytes. Comparison with the gold standard revealed two false negatives and two false positives (potentially true involvement undetected by the gold standard). BMI by PET was seen in 14/46 (30%). Immunophenotype of FL in the bone marrow was highly heterogeneous. The most common phenotypic abnormality was dim expression of CD19 (>0.5 log loss in 30% of patients). CD10 was negative in 13 (37%) and incompletely positive (overlap with the negative population) in a further 8 (28%) while entirely positive only in 14 (48%). Other abnormalities (loss of CD20, gain or loss of CD79b, expression of CD43, and substantial loss of CD45) were rare. Computational analysis by means of FlowSOM confirmed the heterogeneous phenotype, with FL from different patients clustering in unrelated metaclusters. Conclusion: BMI by FL was frequent and immunophenotype was heterogeneous. However, this protocol enabled detection of FL in bone marrow in the vast majority of patients with bone marrow involvement by the gold standard.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 3.284 Quartil: 2 Categoria:

M, Pérez P, Pérez MA, Ramirez JM, Raga X, Lucena J, Aramburu J, Sanfeliu-Riera E, Sauca G, Vilamala A, Rodriguez-Garrido V, Rodriguez G, Tubau F, Quesada MD, Torrellas N, Claver N, Bastida MT, Santos R, GonzalezMoreno O.

Epidemiologia i perfil de resistència antibiòtica de salmonel.la no tifòdica i salmonel.la tífica. Catalunya 20162019. Generalitat de Catalunya. Departament de Salut. Juliol 2022. Disponible en: https://salutpublica.gencat.cat/web/.content/minisite/aspcat/vigilancia_salut_publica/SNMC/resistenciesantimicrobianes/epidemiologia-resistencia-antibiotica-Salmonella-catalunya-2016-2019.pdf

Abstract:

La salmonel·losi és una de les quatre causes principals de malalties diarreiques en l’àmbit mundial i està produïda per la Salmonella, un bacil gramnegatiu que pertany a la família Enterobacteriaceae. El gènere Salmonella es pot dividir en dues espècies (S. enterica i S. bongori), en funció del seu perfil fenotípic. A la vegada Salmonella enterica es diferencia en sis subespècies d’acord amb el seu perfil fenotípic (enterica o I, salamae o II, arizonae o IIIa, diarizonae o IIIb, houtenae o IV i indica o VI). La Salmonella enterica, o subespècie I, és la que s’aïlla més freqüentment en humans. La determinació del serotip és el primer marcador epidemiològic per a la tipificació de les soques de Salmonella i fins avui se n’han identificat més de 2.500 serotips agrupats en més de 50 serogrups. Els diferents serotips de Salmonella també es poden diferenciar segons si estan adaptats o no a hostes o ambients específics. El serotip que té un reservori exclusivament humà és la Salmonella typhi i les Salmonella paratyphi A, B i C també tenen un reservori animal i són anomenades “salmonel·les tifoparatífiques”. Ambdues produeixen febres tifoides. Els serotips ubics, no adaptats a hostes específics, inclouen la majoria dels serotips i són els responsables de la majoria de les gastroenteritis humanes als països desenvolupats i són anomenades “salmonel·les gastroentèriques”. En destaquen com a més freqüents els serotips Salmonella enteritidis i Salmonella typhimurium. L’hàbitat natural de la Salmonella és el tub digestiu d’animals i també d’humans. Hi ha dues vies de transmissió del microorganisme: per ingesta d’aigua o d’aliments contaminats, i per via fecal-oral de persona o animal infectat a persona especialment quan hi ha diarrea. Al nostre medi, els

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Medical Laboratory Technology Posició: 12/29

Ciruela P, Ferré L, Broner S, Esteve S, Coronas L, Piqué M, Mendioroz J, Jané M, Benítez Ma, Pitart C, Ballester F, Falgueras T, Calderon A, Martí C, Curriu M, Comellas E, Ayala PJ, Gallés C, Capdevila E, Hernandez P, Gassiot P, Gómez F, Gonzalez A, Aixalà MJ, Padilla E, Muñoz J, Gené A, Navarro F, Muñoz C, Trujillo G, López J, Mico M, Olsina

Publicacions Científiques CSDM 2022

ous són l’aliment més important de vehiculació de salmonel·les. L’estat de portador crònic és rar en humans, però és comú en els animals. El període de transmissibilitat és molt variable i l’estat de portador temporal pot prolongar-se durant diversos mesos, especialment en els lactants. El tractament antimicrobià pot allargar l’estat de portador. Les altes temperatures faciliten la supervivència i multiplicació de la Salmonella, observant-se un clar predomini de la incidència en els mesos d’estiu. En la salmonel·losi no tifòdica, el període d’incubació és de 6 a 72 hores. Són freqüents les infeccions asimptomàtiques i les formes lleus. Les manifestacions clíniques, quan apareixen, consisteixen en nàusees, vòmits, diarrea, dolor abdominal, febre, cefalea i postració. Pot aparèixer moc i sang a la femta. Aquest quadre s’autolimita i va cedint en un període que va de 3 a 7 dies. Les formes septicèmiques simptomàtiques són poc freqüents, però poden arribar a ser greus quan es tracta d’infants, gent gran o persones immunodeprimides, podent produir osteomielitis, artritis sèptica, meningitis, pneumònia, pericarditis, colecistitis, piodèrmia o pielonefritis. En la salmonel·losi tifòdica, el període d’incubació és de 1 a 2 setmanes. La clínica de la febre tifoide és caracteritza per febre prolongada, cansament, cefalees, nàusees, dolor abdominal i restrenyiment o diarrea, en ocasions apareix una erupció cutània i hipertrofia de la melsa. Els casos greus es poden complicar amb perforació intestinal i hemorràgies. En alguns casos pot provocar la mort.

MEDICINA DE FAMILIA

FAMILY MEDICINE

Depressive symptom severity is a major risk factor for frailty in community- dwelling older adults with depression. A prospective study. Fam Pract. 2022 Mar 4:cmab174. doi: 10.1093/fampra/cmab174. Epub ahead of print. PMID: 35244162.

Abstract

Background: Depression and frailty are closely related, but the mechanisms by which depressed older adults are at an increased risk of becoming frail are still not well understood.

Aim: To assess socioeconomic and depression-related risk factors for frailty in older adults with depression. Methods: Observational and prospective cohort study, with 12-month follow-up, of nonfrail communitydwelling subjects aged ≥70 years old with depression. The main study factors were clinical characteristics of depression, including symptom severity (Hamilton Depression Rating Scale), accompanying anxiety and cognitive symptoms, pharmacological treatment, and social factors including educational level, income, housing conditions and living circumstances, and social network. Frailty status was established according to Fried criteria.

Results: We recruited and analysed 216 subjects (mean age 76.5 years; 74% women), 65 (30%) of whom were lost to follow-up. Annual incidence of frailty was 23.2 new cases/100 persons. Age, female gender, osteoarthritis, pain, number of medications, major depression, first-degree family history of depression, depressive symptom severity, low educational level, and low-income level were risk factors for frailty. The multivariate analysis showed that age (odds ratio [OR] = 1.16; 95% confidence interval [CI]: 1.04-1.29), visual analogue scale (VAS)-pain (OR = 1.25; 95% CI: 1.01-1.55), and severe or very severe depressive symptoms (OR = 37.36; 95% CI: 2.68-518.53) were significantly associated with incident frailty at 12 months of follow-up

Conclusions: Both clinical and social characteristics are risk factors for frailty, but severity of depressive symptoms had the highest independent effect on frailty in depressed aged subjects. Frailty requires a multidisciplinary approach that pays special attention to pain and depressed mood.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.290 Quartil: 3 Categoria: Medicine, General & Internal Posició: 107/172

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Oyon J, Serra-Prat M, Limon E, Ferrer M, Pastor N, Palomera E, Burdoy E

MEDICINA FISICA i REHABILITACIÓ - PHYSICAL MEDICINE & REHABILITATION

Nº Articles indexats: 5 Factor Impacte total: 23.223 Factor d’impacte liderat: 4.997

Garnacho-Castaño MV, Sánchez-Nuño S, Molina-Raya L, Carbonell T, Maté-Muñoz JL, Pleguezuelos-Cobo E, Serra-Payá N.

Circulating nitrate-nitrite reduces oxygen uptake for improving resistance exercise performance after rest time in well-trained CrossFit athletes.

Sci Rep. 2022 Jun 11;12(1):9671. doi: 10.1038/s41598-022-13786-x. PMID: 35690665; PMCID: PMC9188609.

Abstract

This study aimed to determine the effects of circulating nitrate plus nitrite (NOx) concentrations on resistance exercise performance, VO2 and biomarkers of muscle damage. Eleven well-trained male CrossFit athletes (29.2 ± 3.7 years, 78.9 ± 5.4 kg, 175.1 ± 6.3 cm) carried out a resistance exercise test after drinking 140 mL of beetroot juice (BJ) or placebo. The test consisted of repeating the same resistance exercise routine twice: wall ball shots plus full back squat with 3-min rest (1st routine) or without rest (2nd routine) between the two exercises. Higher NOx plasma levels were verified after BJ than placebo in the pretest and post-test (p < 0.001). A higher number of repetitions was observed after BJ intake compared to placebo in the full back squat exercise during the first routine (p = 0.004). A significantly reduced VO2 was detected after BJ intake compared to placebo during rest and full back squat execution in the first routine (p < 0.05). Plasma myoglobin concentrations were significantly increased with BJ compared to placebo (p = 0.036). These results showed that plasma NOx levels reduced VO2 after BJ intake during rest time. These reduced VO2 was a key factor for improving full back squat performance during the first routine.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.997 Quartil: 2 Categoria: Multidisciplinary Sciences Posició: 19/74

Moreira-Reis A, Maté-Muñoz JL, Hernández-Lougedo J, Vilches-Sáez S, Benet M, García-Fernández P, Pleguezuelos E, Carbonell T, Alva N, Garnacho-Castaño MV.

Aerobic Dance on an Air Dissipation Platform Improves Cardiorespiratory, Muscular and Cellular Fitness in the Overweight and Obese Elderly. Biology (Basel). 2022 Apr 11;11(4):579. doi: 10.3390/biology11040579. PMID: 35453778; PMCID: PMC9031850

Abstract

Background: Obesity is a global health problem associated with a high number of comorbidities that decrease functional capacity, especially in elderly people. Aerobic dance is considered a viable strategy to prevent the effects of aging, mainly in obese and overweight elderly people. This study aimed to evaluate the effects of aerobic dance on an air dissipation platform (ADP) on body composition, oxidative stress and muscular and cardiorespiratory fitness in elderly people.

Methods: In total, 32 elderly adults (67.1 ± 3.6) were divided into 3 groups based on body mass index: healthy (HG), overweight (OWG) and obese (OG). Training program of aerobic dance on an ADP was carried out twice a week for 12 weeks.

Results: OWG (p = 0.016) and OG decreased their weight (p &lt; 0.001). There was a significant decrease in malondialdehyde concentrations in all experimental groups (p &lt; 0.05). OWG and OG significantly improved their peak oxygen uptake (p &lt; 0.01). HG increased the vertical jump height (p &lt; 0.05), and HG and OG improved the power output of the lower extremities (p &lt; 0.05).

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Conclusions: The aerobic dance on an ADP may be an effective alternative to lose weight, prevent oxidative stress and improve cardiorespiratory fitness in obese and overweight elderly people.

Indexat a: PubMed/WOS/JCR

Factor Impacte: 5.168

Quartil: 1 Categoria: Biology Posició: 21/94

Similar Slow Component of Oxygen Uptake and Ventilatory Efficiency between an Aerobic Dance Session on an Air Dissipation Platform and a Constant-Load Treadmill Test in Healthy Women.

Biology (Basel). 2022 Nov 10;11(11):1646. doi: 10.3390/biology11111646. PMID: 36358347

Abstract

There is a lack of evidence about the slow component of oxygen consumption (V.O2sc) and ventilatory efficiency (slope VE·VCO2-1) during an aerobic dance (AD) session on an air dissipation platform (ADP) despite the key role played in endurance exercises. This research was designed to assess V.O2sc, ventilatory efficiency, and blood lactate concentration by comparing two exercise modes: AD session on an ADP versus treadmill test at a constant-load intensity of the first ventilatory threshold (VT1). In the first session, an incremental treadmill test was completed. In sessions 2 and 3, the participants were randomly assigned to the AD session on an ADP or to a treadmill constant-load test at VT1 intensity to determine their cardioventilatory responses. In addition, their blood lactate levels and ratings of perceived exertion (RPE, CR-10) were evaluated. No significant differences were found between the constant-load treadmill test and AD session on an ADP with respect to V.O2sc, VE VCO2-1 slope, and RPE (p &gt; 0.05). Higher blood lactate concentrations were observed in an AD session on an ADP than in a constant-load treadmill test at 10 min (p = 0.003) and 20 min (p &lt; 0.001). The two different exercise modalities showed similar V.O2sc and VE·VCO2-1 slope, even though the blood lactate concentrations were different.

Indexat a: PubMed/WOS/JCR Factor Impacte: 5.168 Quartil: 1 Categoria: Biology Posició: 21/94

Int J Chron Obstruct Pulmon Dis. 2022 Nov 5;17:2835-2846. doi: 10.2147/COPD.S381427. PMID: 36381995; PMCID: PMC9645109

Abstract

Purpose: The Spanish Activity Questionnaire in COPD (SAQ-COPD) is a short, simple physical activity (PA) measurement instrument for patients with chronic obstructive pulmonary disease (COPD). In this study, we analyzed its validity and sensitivity to change.

Methods: Prospective scale validation study. An accelerometer (DynaPort MoveMonitor®) and the Yale Physical Activity Survey (YPAS) were used as reference standards. The analyses examined the criterion validity (Spearman correlations), internal consistency (Cronbach's alpha), factorial structure, test-retest reliability (intraclass correlation coefficient, ICC), sensitivity to change and receiver operating characteristic (ROC) curve to classify patients with low PA.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Moreira-Reis A, Maté-Muñoz JL, Hernández-Lougedo J, García-Fernández P, Heredia-Elvar JR, Pleguezuelos E, Carbonell T, Alva N, Garnacho-Castaño MV.

Soler-Cataluña JJ, Puente Maestu L, Román Rodríguez M, Esteban C, Gea J, Bernabeu Mora R, Pleguezuelos Cobo E, Ancochea J, García-Río F. Validation of the Spanish Activity Questionnaire in COPD (SAQ-COPD) in Patients with Chronic Obstructive Pulmonary Disease.

Publicacions Científiques CSDM 2022

Results: A total of 300 patients diagnosed with COPD were analyzed (73% males, mean age 66 ± 8 years, 40.3% with severe airflow limitation). Cronbach's alpha was 0.60 and Spearman's correlations with accelerometer measurements of PA [number of steps, metabolic equivalents (MET), physical activity level (PAL)] and YPAS ranged from 0.37 to 0.53 (all p < 0.001). ICC was 0.69 (95% CI 0.61-0.74) and the area under the ROC curve to identify low PA was 0.65 (95% confidence interval: 0.58-0.73). Significant variations in SAQ-COPD scores were found between groups defined by YPAS for change.

Conclusion: The SAQ-COPD questionnaire is a valid instrument for classifying PA in patients with COPD. Correlations with other instruments provide criterion validity and also demonstrate good sensitivity to change

Indexat a: PubMed/WOS/JCR

Factor Impacte: 2.893 Quartil: 3 Categoria: Respiratory System Posició: 49/66

Impaired pulmonary and muscle function during moderate exercise in female patients recovered from SARSCoV-2.

Sci Rep. 2022 Dec 4;12(1):20943. doi: 10.1038/s41598-022-24941-9. PMID:36464697; PMCID: PMC9719894

Abstract

This study aimed to assess pulmonary and muscle dysfunction by analyzing the slow component of oxygen uptake (VO2SC), and mechanical and ventilatory efficiency in adult women recovered from the severe acute respiratory syndrome coronavirus type II (SARS-CoV-2) during a constant load test. 32 women (N = 17 patients with SARS-CoV-2; N = 15 control group) performed two cardiopulmonary exercise tests (CPX) on a cycle ergometer. In the first test, the participants performed incremental CPX until extenuation. In the second test the participants performed a 10-min CPX at a constant load intensity (watts) corresponding to the first ventilatory threshold. There was a 48-72 h rest period between the two tests. There was a significant increase in the VO2SC in the patients recovered from SARS-CoV-2 (160.4 ± 60 mL min-1) in comparison with the healthy participants (59.6 ± 65 mL min-1) (P < 0.001). Mechanical efficiency significantly decreased in patients recovered from SARSCoV-2 compared to the control group (P = 0.04). Ventilatory inefficiency significantly increased in the patients recovered from SARS-CoV-2 compared with the control group (P < 0.001). Adult women recovered from SARSCoV-2 infection have important pulmonary and muscular dysfunction and fatigue which contributes to increasing the VO2SC and reducing mechanical and ventilatory efficiency during mild-moderate exercise at a

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Pleguezuelos E, Del Carmen A, Moreno E, Ortega P, Robles A, Serra-Prat M, Miravitlles M, Yebenes JC, Garnacho-Castaño MV

Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID19: CIBERESUCICOVID study.

Intensive Care Med. 2022 Jun 21. doi:10.1007/s00134-022-06726-w. Epub ahead of print. PMID: 35727348

Abstract:

Purpose: Although there is evidence supporting the benefits of corticosteroids in patients affected with severe coronavirus disease 2019 (COVID-19), there is little information related to their potential benefits or harm in some subgroups of patients admitted to the intensive care unit (ICU) with COVID-19. We aim to investigate to find candidate variables to guide personalized treatment with steroids in critically ill patients with COVID-19.

Methods: Multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish ICUs. The primary outcome was 90-day mortality. Subsequent analyses in clinically relevant subgroups by age, ICU baseline illness severity, organ damage, laboratory findings and mechanical ventilation were performed. High doses of corticosteroids (≥ 12 mg/day equivalent dexamethasone dose), early administration of corticosteroid treatment (< 7 days since symptom onset) and long term of corticosteroids (≥ 10 days) were also investigated.

Results: Between February 2020 and October 2021, 4226 patients were included. Of these, 3592 (85%) patients had received systemic corticosteroids during hospitalisation. In the propensity-adjusted multivariable analysis, the use of corticosteroids was protective for 90-day mortality in the overall population (HR 0.77 [0.65-0.92], p = 0.003) and in-hospital mortality (SHR 0.70 [0.58-0.84], p < 0.001). Significant effect modification was found after adjustment for covariates using propensity score for age (p = 0.001 interaction term), Sequential Organ Failure Assessment (SOFA) score (p = 0.014 interaction term), and mechanical ventilation (p = 0.001 interaction term). We observed a beneficial effect of corticosteroids on 90-day mortality in various patient subgroups, including those patients aged ≥ 60 years; those with higher baseline severity; and those receiving invasive mechanical ventilation at ICU admission. Early administration was associated with a higher risk of 90-day mortality in the overall population (HR 1.32 [1.14-1.53], p < 0.001). Long-term use was associated with a lower risk of 90-day mortality in the overall population (HR 0.71 [0.61-0.82], p < 0.001). No effect was found regarding the dosage of corticosteroids. Moreover, the use of corticosteroids was associated with an increased risk of nosocomial bacterial pneumonia and hyperglycaemia.

Conclusion: Corticosteroid in ICU-admitted patients with COVID-19 may be administered based on age, severity, baseline inflammation, and invasive mechanical ventilation. Early administration since symptom onset may prove harmful.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

de la Gándara A, Martínez Varela I, López Messa J, Albaiceta GM, Nieto M, Novo MA, Peñasco Y, Pérez-García F, Pozo-Laderas JC, Ricart P, Sagredo V, Sánchez-Miralles A, Sancho Chinesta S, Serra-Fortuny M, Socias L, SoléViolan J, Suarez-Sipmann F, Tamayo Lomas L, Trenado J, Úbeda A, Valdivia LJ, Vidal P, Barbé F; CIBERESUCICOVID Project Investigators.

Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study.

Lancet Reg Health Eur. 2022 May 29;18:100422. doi: 10.1016/j.lanepe.2022.100422. PMID: 35655660; PMCID: PMC9148543

Abstract:

Background: The clinical heterogeneity of COVID-19 suggests the existence of different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill COVID-19 patients and assess their impact on in-hospital outcomes, response to treatment and sequelae.

Methods: Multicenter prospective/retrospective observational study in intensive care units of 55 Spanish hospitals. 5866 PCR-confirmed COVID-19 patients had comorbidities recorded at hospital admission; clinical and biological parameters, in-hospital procedures and complications throughout the stay; and, clinical complications, persistent symptoms and sequelae at 3 and 6 months.

Findings: Latent class analysis identified 3 phenotypes using training and test subcohorts: low-morbidity (n=3385; 58%), younger and with few comorbidities; high-morbidity (n=2074; 35%), with high comorbid burden; and renal-morbidity (n=407; 7%), with chronic kidney disease (CKD), high comorbidity burden and the worst oxygenation profile. Renal-morbidity and high-morbidity had more in-hospital complications and higher mortality risk than low-morbidity (adjusted HR (95% CI): 1.57 (1.34-1.84) and 1.16 (1.05-1.28), respectively). Corticosteroids, but not tocilizumab, were associated with lower mortality risk (HR (95% CI) 0.76 (0.63-0.93)), especially in renal-morbidity and high-morbidity. Renal-morbidity and high-morbidity showed the worst lung function throughout the follow-up, with renal-morbidity having the highest risk of infectious complications (6%), emergency visits (29%) or hospital readmissions (14%) at 6 months (p<0.01).

Interpretation: Comorbidity-based phenotypes were identified and associated with different expression of inhospital complications, mortality, treatment response, and sequelae, with CKD playing a major role. This could help clinicians in day-to-day decision making including the management of post-discharge COVID-19 sequelae

Indexat a: MEDLINE/WOS

Cantón-Bulnes ML, Pérez CC, Carbonell N, Catalán-González M, de Frutos R, Franco N, Galbán C, Gumucio-Sanguino VD, de la Torre MC, Díaz E, Estella Á, Gallego E, Garmendia JLG, Gómez JM, Huerta A, García RNJ, Loza-Vázquez A, Marin-Corral J, Delgado MCM, Gándara AM, Varela IM, Messa JL, Albaiceta GM, Nieto M, Novo MA, Peñasco Y, Pérez-García F, Pozo-Laderas JC, Ricart P, Sagredo V, Sánchez-Miralles Á, Chinesta SS, Serra-Fortuny M, Socias L, Solé-Violan J, Suárez-Sipmann F, Lomas LT, Trenado J, Úbeda A, Valdivia LJ, Vidal P, Barbé F; CIBERESUCICOVID Project (COV20/00110, ISCIII).

Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units.

Arch Bronconeumol. 2022 Apr;58 Suppl 1:22-31. doi: 10.1016/j.arbres.2022.03.010. Epub 2022 Apr 15. PMID: 35491287; PMCID:PMC9012512.

Abstract:

Introduction: The COVID-19 pandemic created tremendous challenges for health-care systems. Intensive care units (ICU) were hit with a large volume of patients requiring ICU admission, mechanical ventilation, and other organ support with very high mortality. The Centro de Investigación Biomédica en Red-Enfermedades

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Añón JM, Carbajales Pérez C, Sagredo V, Bofill N, Carbonell N, Socias L, Barberà C, Estella A, Valledor Mendez M, Diaz E, López Lago A, Torres A, Barbé F; CIBERESUCICOVID Project (COV20/00110, ISCIII).

Torres A, Motos A, Ceccato A, Bermejo-Martin J, de Gonzalo-Calvo D, Pérez R, Barroso M, Pascual IZ, Gonzalez J, Fernández-Barat L, Ferrer R, Riera J, García Gasulla D, Peñuelas O, Lorente JÁ, Almansa R, Menéndez R, Kiarostami K, Canseco J, Villar RA, Añón JM, Mariño AB, Barberà C, Barberán J, Ortiz AB, Boado MV, BustamanteMunguira E, Caballero J,

Publicacions Científiques CSDM 2022

Respiratorias (CIBERES), a network of Spanish researchers to investigate in respiratory disease, commissioned the current proposal in response to the Instituto de Salud Carlos III (ISCIII) call.

Methods: CIBERESUCICOVID is a multicenter, observational, prospective/retrospective cohort study of patients with COVID-19 admitted to Spanish ICUs. Several work packages were created, including study population and ICU data collection, follow-up, biomarkers and miRNAs, data management and quality.

Results: This study included 6102 consecutive patients admitted to 55 ICUs homogeneously distributed throughout Spain and the collection of blood samples from more than 1000 patients. We enrolled a large population of COVID-19 ICU-admitted patients including baseline characteristics, ICU and MV data, treatments complications, and outcomes. The in-hospital mortality was 31%, and 76% of patients required invasive mechanical ventilation. A 3-6 month and 1 year follow-up was performed. Few deaths after 1 year discharge were registered. Low anti-SARS-CoV-2 S antibody levels predict mortality in critical COVID-19. These antibodies contribute to prevent systemic dissemination of SARS-CoV-2. The severity of COVID-19 impacts the circulating miRNA profile. Plasma miRNA profiling emerges as a useful tool for risk-based patient stratification in critically ill COVID-19 patients.

Conclusions: We present the methodology used in a large multicenter study sponsored by ISCIII to determine the short- and long-term outcomes in patients with COVID-19 admitted to more than 50 Spanish ICUs.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 6.333 Quartil:1 Categoria: Respiratory System Posició: 14/66

Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to

observational retrospective study. Crit Care. 2022 Feb 8;26(1):37. doi: 10.1186/s13054-022-03905-5. PMID: 35135588; PMCID: PMC8822661.

Abstract:

Background: Non-invasive oxygenation strategies have a prominent role in the treatment of acute hypoxemic respiratory failure during the coronavirus disease 2019 (COVID-19). While the efficacy of these therapies has been studied in hospitalized patients with COVID-19, the clinical outcomes associated with oxygen masks, highflow oxygen therapy by nasal cannula and non-invasive mechanical ventilation in critically ill intensive care unit (ICU) patients remain unclear.

Methods: In this retrospective study, we used the best of nine covariate balancing algorithms on all baseline covariates in critically ill COVID-19 patients supported with > 10 L of supplemental oxygen at one of the 26 participating ICUs in Catalonia, Spain, between March 14 and April 15, 2020.

Results: Of the 1093 non-invasively oxygenated patients at ICU admission treated with one of the three standalone non-invasive oxygenation strategies, 897 (82%) required endotracheal intubation and 310 (28%) died during the ICU stay. High-flow oxygen therapy by nasal cannula (n = 439) and non-invasive mechanical ventilation (n = 101) were associated with a lower rate of endotracheal intubation (70% and 88%, respectively) than oxygen masks (n = 553 and 91% intubated), p < 0.001. Compared to oxygen masks, high-flow oxygen therapy by nasal cannula was associated with lower ICU mortality (hazard ratio 0.75 [95% CI 0.58-0.98), and the hazard ratio for ICU mortality was 1.21 [95% CI 0.80-1.83] for non-invasive mechanical ventilation.

Conclusion: In critically ill COVID-19 ICU patients and, in the absence of conclusive data, high-flow oxygen therapy by nasal cannula may be the approach of choice as the primary non-invasive oxygenation support strategy.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Wendel-Garcia PD, Mas A, González-Isern C, Ferrer R, Máñez R, Masclans JR, Sandoval E, Vera P, Trenado J, Fernández R, Sirvent JM, Martínez M, Ibarz M, Garro P, Lopera JL, Bodí M, Yébenes-Reyes JC, Triginer C, Vallverdú I, Baró A, Bodí F, Saludes P, Valencia M, Roche-Campo F, Huerta A, Cambra FJ, Barberà C, Echevarria J, Peñuelas Ó, Mancebo J; UCIsCAT study group.

the ICU: a multicenter

Publicacions Científiques CSDM 2022

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 19.344 Quartil:1 Categoria: Critical Care Medicine Posició: 4/35

Lorencio Cárdenas C, Yébenes JC, Vela E, Clèries M, Sirvent JM, Fuster-Bertolín C, Reina C, Rodríguez A, RuizRodríguez JC, Trenado J, Esteban Torné E.

Trends in mortality in septic patients according to the different organ failure during 15 years. Crit Care. 2022 Oct 3;26(1):302. doi: 10.1186/s13054-022-04176-w. PMID: 36192781; PMCID: PMC9528124.

Abstract:

Background: The incidence of sepsis can be estimated between 250 and 500 cases/100.000 people per year and is responsible for up to 6% of total hospital admissions. Identified as one of the most relevant global health problems, sepsis is the condition that generates the highest costs in the healthcare system. Important changes in the management of septic patients have been included in recent years; however, there is no information about how changes in the management of sepsis-associated organ failure have contributed to reduce mortality.

Methods: A retrospective analysis was conducted from hospital discharge records from the Minimum Basic Data Set Acute-Care Hospitals (CMBD-HA in Catalan language) for the Catalan Health System (CatSalut). CMBD-HA is a mandatory population-based register of admissions to all public and private acute-care hospitals in Catalonia. Sepsis was defined by the presence of infection and at least one organ dysfunction. Patients hospitalized with sepsis were detected, according ICD-9-CM (since 2005 to 2017) and ICD-10-CM (2018 and 2019) codes used to identify acute organ dysfunction and infectious processes.

Results: Of 11.916.974 discharges from all acute-care hospitals during the study period (2005-2019), 296.554 had sepsis (2.49%). The mean annual sepsis incidence in the population was 264.1 per 100.000 inhabitants/year, and it increased every year, going from 144.5 in 2005 to 410.1 in 2019. Multiorgan failure was present in 21.9% and bacteremia in 26.3% of cases. Renal was the most frequent organ failure (56.8%), followed by cardiovascular (24.2%). Hospital mortality during the study period was 19.5%, but decreases continuously from 25.7% in 2005 to 17.9% in 2019 (p < 0.0001). The most important reduction in mortality was observed in cases with cardiovascular failure (from 47.3% in 2005 to 31.2% in 2019) (p < 0.0001). In the same way, mean mortality related to renal and respiratory failure in sepsis was decreased in last years (p < 0.0001).

Conclusions: The incidence of sepsis has been increasing in recent years in our country. However, hospital mortality has been significantly reduced. In septic patients, all organ failures except liver have shown a statistically significant reduction on associated mortality, with cardiovascular failure as the most relevant.

Indexat a: MEDLINE/WOS/JCR

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

It has recently been evidenced that COVID-19 pneumonia is associated with respiratory failure and ARDS, which may require invasive mechanical ventilation (IMV) in the more serious cases. It has been seen that ARDS COVID19 patients requiring IMV have a higher incidence of barotrauma than patients with ARDS due to other etiologies, even with the use of protective ventilation strategies. Barotrauma can manifest as pneumothorax (PTX), pneumomediastinum (PMD) or subcutaneous emphysema.3

In an attempt to predict the risk of PTX/PMD in ARDS COVID-19 patients requiring IMV, use has been made of the Macklin effect, described as a lineal accumulation of air adjacent to the bronchovascular sheath in the lung parenchyma window of the thoracic CT scan, as an early radiological predictor allowing the selection of patients who are more likely to develop this complication. We report the incidence of barotrauma in our Intensive Care Unit (ICU) of Hospital de Mataró (Mataró, Spain) and the number of patients with PTX/PMD in which the Macklin effect was observed in the lung parenchyma window of a thoracic CT scan performed before the first radiological evidence of the disorder.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.799 Quartil:3 Categoria: Critical Care Medicine Posició: 24/35

Is sèrum hyperosmolality related with myocardial dysfunction in septic shock patients?

Eur J Intern Med. 2022 Jan;95:108-110. doi: 10.1016/j.ejim.2021.09.015. Epub 2021 Oct 4. PMID: 34620541.

Abstract: Etiopathogenesis of cardiac dysfunction in septic shock is multifactorial, arising from autonomic dysregulation, increased capillary permeability, metabolic and mitochondrial dysfunction, oxidative stress, and activation of cytokines and inflammatory factors. Transthoracic echocardiography is the main tool to early diagnose cardiac dysfunction in septic shock patients, but the use of complementary tools to improve the diagnose and treatment of these patients is much warranted.

In the present study we analysed the relationship between blood osmolyte curve in the first 72h after ICU admission and myocardial dysfunction diagnosed by transthoracic echocardiography in septic shock patients. The study had been approved by the Ethical Committee (CEIm) of the University Hospital of Girona Dr. Josep Trueta (reference 2012.127); an informed consent was requested from all enrolled patients or their relatives.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 7.749 Quartil: 1 Categoria: medicine, General & Internal Posició: 26/172

Martin-Loeches I, Motos A, Menéndez R, Gabarrús

J, Carbajales C, Carbonell N, Catalán-González M, Galbán C, Gumucio-Sanguino VD, de la Torre MC, Díaz E, Gallego E, García Garmendia JL, Garnacho-Montero J, Gómez JM, Jorge García RN, Loza-Vázquez A, Marín-Corral J, Martínez de la Gándara A, Martínez Varela I, Lopez Messa J, Albaiceta GM, Novo MA, Peñasco Y, Ricart P, UrreloCerrón L, Sánchez-Miralles A, Sancho Chinesta S, Socias L, Solé-Violan J, Tamayo Lomas L, Vidal P, Torres A. ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome. J Clin Med. 2021 Dec 31;11(1):224. doi: 10.3390/jcm11010224. PMID: 35011967; PMCID:PMC8746263

Abstract:

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Murcia-Gubianas C, Yébenes JC, Buxó M, Foradada S, Pinart E.

Publicacions Científiques CSDM 2022

Background: Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associated with the characteristics of persistent COVID-19. On the other hand, these patients very often have intensive care unitacquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence on poor health post-COVID 19 syndrome in ICU-discharged patients.

Methods: This prospective, multicentre, and observational study was carrid out across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge.

Results: A total of 1255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP). Patients requiring invasive mechanical ventilation had more persistent post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, development of ICUAP, and ARDS were independent factors for persistent poor health post-COVID-19.

Conclusions: Persistent post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay, development of ICUAP, and ARDS all comprised independent factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-COVID-19.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.964 Quartil: 2 Categoria: medicine, General & Internal Posició: 55/172

Int J Environ Res Public Health. 2022 Nov 6;19(21):14557. doi: 10.3390/ijerph192114557. PMID: 36361437; PMCID: PMC9658367.

Abstract: This study aims to evaluate the effect of regularly reporting spirometry results during smoking cessation counseling from a primary care physician on the quit rate in adult smokers.

Methods: A randomized, two-arm intervention study was conducted at six primary care centers. A total of 350 smokers, ≥18 years of age, who consulted their primary care physician, participated in the study. At the selection visit, smokers who gave their consent to participate underwent spirometry. Subsequently, an appointment (visit 0) was scheduled to complete a nicotine dependence test, a smoking cessation motivation questionnaire, and a sociodemographic questionnaire. Participants were also offered brief, structured advice on how to quit smoking, as well as detailed information on spirometry results. Patients were then randomized and scheduled for follow-up visits at 3, 6, 12, and 24 months. Both arms received brief, structured advice and detailed information on spirometry results at visit 0. At consecutive follow-up visits, the control group only received brief, structured smoking cessation advice, while the intervention group also received information on initial spirometry results at visits 3 and 6, and a spirometry retest at visit 12. Exhaled carbon monoxide testing was used to check smoking cessation.

Results: The study included 350 smokers; 179 were assigned to the control group and 171 to the intervention group. Smoking cessation at one year was 24.0% in the intervention group compared to 16.2% in the control group. At two years, it was 25.2% in the intervention group and 18.4% in the control group. Overall, the adjusted odds of quitting smoking in the intervention group were 42% higher than in the control group (p = 0.018).

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Rodriguez-Alvarez MDM, Roca-Antonio J, Martínez-González S, Vilà-Palau V, Chacón C, Ortega-Roca A, BorrellThiò E, Erazo S, Almirall-Pujol J, Torán-Monserrat P. Spirometry and Smoking Cessation in Primary Care: The ESPIROTAB STUDY, A Randomized Clinical Trial.

Publicacions Científiques CSDM 2022

Conclusions: Regular and detailed feedback of spirometry results with smokers increases smoking cessation. Specifically, the likelihood of quitting smoking in the intervention group is 1.42 times higher than in the control group (p = 0.018).

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.614 Quartil: 2 Categoria: Public, Environmental & Occupat. Health Posició: 71/210

Riera J, Barbeta E, Tormos A, Mellado-Artigas R, Ceccato A, Motos A, Fernández-Barat L, Ferrer R, García-Gasulla D, Peñuelas O, Lorente JÁ, Menéndez R, Roca O, Palomeque A, Ferrando C, Solé-Violán J, Novo M, Boado MV, Tamayo L, Estella Á, Galban C, Trenado J, Huerta A, Loza A, Aguilera L, Garmendia JLG, Barberà C, Gumucio V, Socias L, Franco N, Valdivia LJ, Vidal P, Sagredo V, Ruiz- García ÁL, Varela IM, López J, Pozo JC, Nieto M, Gómez JM, Blandino A, Valledor M, Bustamante-Munguira E, Sánchez-Miralles Á, Peñasco Y, Barberán J, Ubeda A, Amaya-Villar R, Martín MC, Jorge R, Caballero J, Marin J, Añón JM, Sipmann FS, Muñiz G, Castellanos-Ortega Á, Adell-Serrano B, Catalán M, de la Gándara AM, Ricart P, Carbajales C, Rodríguez A, Díaz E, de la Torre MC, Gallego E, Cantón- Bulnes L, Carbonell N, González J, de Gonzalo-Calvo D, Barbé F, Torres A; CiberesUCICOVID Consortium.

Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis.

Eur Respir J. 2022 Nov 17:2201426. doi: 10.1183/13993003.01426-2022. Epub ahead of print. PMID: 36396142

Abstract:

Background: The primary aim of our study was to investigate the association between intubation timing and hospital mortality in critically ill patients with COVID-19-associated respiratory failure. We also analysed both the impact of such timing throughout the first four pandemic waves and the influence of prior non-invasive respiratory support on outcomes.

Methods: This is a secondary analysis of a multicentre, observational and prospective cohort study that included all consecutive patients undergoing invasive mechanical ventilation due to COVID-19 from across 58 Spanish intensive care units (ICU) participating in the CIBERESUCICOVID project. The study period was between 29 February 2020 and 31 August 2021. Early intubation was defined as that occurring within the first 24 h of intensive care unit (ICU) admission. Propensity score (PS) matching was used to achieve balance across baseline variables between the early intubation cohort and those patients who were intubated after the first 24 h of ICU admission. Differences in outcomes between early and delayed intubation were also assessed. We performed sensitivity analyses to consider a different timepoint (48 h from ICU admission) for early and delayed intubation. Results: Of the 2725 patients who received invasive mechanical ventilation, a total of 614 matched patients were included in the analysis (307 for each group). In the unmatched population, there were no differences in mortality between the early and delayed groups. After PS matching, patients with delayed intubation presented higher hospital mortality (27.3% versus 37.1%, p =0.01), ICU mortality (25.7% versus 36.1%, p=0.007) and 90-day mortality (30.9% versus 40.2%, p=0.02) when compared to the early intubation group. Very similar findings were observed when we used a 48-hour timepoint for early or delayed intubation. The use of early intubation decreased after the first wave of the pandemic (72%, 49%, 46% and 45% in the first, second, third and fourth wave, respectively; first versus second, third and fourth waves p<0.001). In both the main and sensitivity analyses, hospital mortality was lower in patients receiving high-flow nasal cannula (n=294) who were intubated earlier. The subgroup of patients undergoing NIV (n=214) before intubation showed higher mortality when delayed intubation was set as that occurring after 48 h from ICU admission, but not when after 24 h. Conclusions: In patients with COVID-19 requiring invasive mechanical ventilation, delayed intubation was associated with a higher risk of hospital mortality. The use of early intubation significantly decreased throughout

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Publicacions Científiques CSDM 2022

the course of the pandemic. Benefits of such an approach occurred more notably in patients who had received high-flow nasal cannula.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 33.801 Quartil: 1 Decil: 1 Categoria: Respiratory System Posició: 2/66

MEDICINA INTERNA

–

INTERNAL MEDICINE

Nº Articles indexats: 12 Factor Impacte total: 53.765 Factor d’impacte liderat: 8.111

Boixeda R, Moreno MI, Bartolomé M, Juanola J; en nombre del grupo GEMPaC. Incidencia de agudizaciones en la EPOC: estudio INAMPOC. Importancia del error diagnóstico. Aten Primaria. 2022 Jun 9;54(8):102389. Spanish. doi:10.1016/j.aprim.2022.102389. Epub ahead of print. PMID: 35691216.

Abstract

El estudio EPISCAN II estimó la prevalencia de la EPOC en el 11,4% de la población en España, y describió un infradiagnóstico que se situaba alrededor del 75%. Se han descrito entre 2 y 3 episodios de exacerbación por paciente al año, siendo la mayor parte ambulatorias, y sobre un 50% desconocidas por el equipo asistencial2. El objetivo de nuestro estudio es describir la incidencia de las agudizaciones de la EPOC (AEPOC), así como evaluar la incidencia de ingreso hospitalario por agudización o por neumonía. Como objetivo secundario analizamos el error diagnóstico de nuestra población de estudio al evaluar el registro de una espirometría en los registros electrónicos en la base de datos del sistema de salud (REBDSS), y poder calcular la prevalencia de EPOC según estos registros.

Se realizó un estudio observacional de base poblacional con identificación prospectiva y sistemática durante un año de todas las AEPOC de la población adscrita a 3 áreas básicas de salud mediante un sistema de vigilancia activa que incluyó una red de profesionales sanitarios tanto a nivel ambulatorio como hospitalario en el hospital de referencia.

La población de estudio eran los pacientes mayores de 35 años con diagnóstico de EPOC en los registros del sistema de salud con los códigos ICD-10 (J 44.9) en la ciudad de Mataró y adscritos a los centros de salud Mataró-Centre (MC) y Cirera-Molins (CM), y los residentes en Vilassar de Dalt (VD).

Se estimó la incidencia anual de AEPOC al dividir los pacientes que consultaban por una agudización o ingreso hospitalario en el período de estudio por los pacientes con diagnóstico de EPOC en los REBDSS en fecha de 15 de marzo de 2015. Se asumió la estabilidad de la población de estudio durante el año de reclutamiento.?Los datos se presentaban como incidencia anual con un intervalo de confianza (IC) del 95%.

Se revisó la historia clínica de los pacientes y se identificó y registró la presencia de una espirometría en todos los pacientes, clasificando los pacientes en 3 grupos: pacientes con una espirometría con datos de obstrucción (EPOC confirmada), pacientes sin espirometría realizada o registrada (EPOC no confirmada) y los pacientes con espirometría sin patrón espirométrico (sobrediagnóstico).

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.206 Quartil:3 Categoria: Medicine, General & Internal Posició: 110/172

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Publicacions Científiques CSDM 2022

Badia-Cebada L, Peñafiel J, López-Contreras J, Pomar V, Martínez JA, Santana G, Cuquet J, Montero MM, Hidalgo-López C, Andrés M, Gimenez M, Quesada MD, Vaqué M, Iftimie S, Gudiol C, Pérez R, Coloma A, Marron A, Barrufet P, Marimon M, Lérida A, Clarós M, Ramírez-Hidalgo MF, Garcia Pardo G, Martinez MJ, Chamarro EL, Jiménez-Martínez E, Hornero A, Limón E, López M, Calbo E, Pujol M, Gasch O; Surveillance of health-care associated infections in Catalonia (VINCat). Decreased mortality among patients with catheter-related bloodstream infections at Catalan hospitals (2010-2019). J Hosp Infect. 2022 May 18;126:70-77. doi: 10.1016/j.jhin.2022.05.009. Epub ahead of print. PMID: 35594988

Abstract

Background: The incidence of catheter-related bloodstream infections (CRBSIs) has fallen over the last decade, especially in intensive care units (ICUs).

Aim: To assess the existence of concomitant trends in outcomes and to analyse the current risk factors for mortality.

Methods: A multicentre retrospective cohort study was conducted at 24 Catalan hospitals participating in the Surveillance of healthcare-associated infections in Catalonia (VINCat). All hospital-acquired CRBSI episodes diagnosed from January 2010 to December 2019 were included. A common protocol including epidemiological, clinical, and microbiological data was prospectively completed. Mortality at 30 days after bacteraemia onset was analysed using the Cox regression model.

Findings: Over the study period, 4795 episodes of CRBSI were diagnosed. Among them, 75% were acquired in conventional wards and central venous catheters were the most frequently involved (61%). The 30-day mortality rate was 13.8%, presenting a significant downward trend over the study period: from 17.9% in 2010 to 10.6% in 2019 (hazard ratio (HR): 0.95; 95% confidence interval (CI): 0.92-0.98). The multivariate analysis identified age (HR: 1.03; 95% CI: 1.02-1.04), femoral catheter (1.78; 1.33-2.38), medical ward acquisition (2.07; 1.62-2.65), ICU acquisition (3.45; 2.7-4.41), S. aureus (1.59; 1.27-1.99) and Candida sp. (2.19; 1.64-2.94) as risk factors for mortality, whereas the mortality rate associated with episodes originating in peripheral catheters was significantly lower (0.69; 0.54-0.88).

Conclusion: Mortality associated with CRBSI has fallen in recent years but remains high. Intervention programmes should focus especially on ICUs and medical wards, where incidence and mortality rates are highest.

Indexat a: MEDLINE/WOS/JCR Factor Impacte: 8.944 Quartil: 1

Infectious Diseases Posició: 18/95 Fanciulli C, Berenguer J, Busca C, Vivancos MJ, Téllez MJ, Domínguez L, Domingo P, Navarro J, Santos J, Iribarren JA, Morano L, Artero A, Moreno J, Rivero-Román A, Santos I, Giner L, Armiñanzas C, Montero M, Manzardo C, Cifuentes C, García C, Galindo MJ, Ferrero OL, Sanz J, de la Fuente B, Rodríguez C, Gaspar G, Pérez L, Losa JE, Force L, Veloso S, Martínez-Alfaro E, Jarrín I, De Miguel M, González Garcia J; GeSIDA 8514 Study Group. Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019.

HIV Med. 2022 Aug;23(7):705-716. doi: 10.1111/hiv.13229. Epub 2022 Jan 17. PMID: 35037379.

Abstract:

El estudio EPISCAN II1 estimó la prevalencia de la EPOC en el 11,4% de la población en España, y describió un infradiagnóstico que se situaba alrededor del 75%. Se han descrito entre 2 y 3 episodios de exacerbación por paciente al año, siendo la mayor parte ambulatorias, y sobre un 50% desconocidas por el equipo asistencial2. El objetivo de nuestro estudio es describir la incidencia de las agudizaciones de la EPOC (AEPOC), así como evaluar la incidencia de ingreso hospitalario por agudización o por neumonía. Como objetivo secundario analizamos el error diagnóstico de nuestra población de estudio al evaluar el registro de una espirometría en los

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

registros electrónicos en la base de datos del sistema de salud (REBDSS), y poder calcular la prevalencia de EPOC según estos registros.

Se realizó un estudio observacional de base poblacional con identificación prospectiva y sistemática durante un año de todas las AEPOC de la población adscrita a 3 áreas básicas de salud mediante un sistema de vigilancia activa que incluyó una red de profesionales sanitarios tanto a nivel ambulatorio como hospitalario en el hospital de referencia.

La población de estudio eran los pacientes mayores de 35 años con diagnóstico de EPOC en los registros del sistema de salud con los códigos ICD-10 (J 44.9) en la ciudad de Mataró y adscritos a los centros de salud Mataró-Centre (MC) y Cirera-Molins (CM), y los residentes en Vilassar de Dalt (VD).

Se estimó la incidencia anual de AEPOC al dividir los pacientes que consultaban por una agudización o ingreso hospitalario en el período de estudio por los pacientes con diagnóstico de EPOC en los REBDSS en fecha de 15 de marzo de 2015. Se asumió la estabilidad de la población de estudio durante el año de reclutamiento.?Los datos se presentaban como incidencia anual con un intervalo de confianza (IC) del 95%.

Se revisó la historia clínica de los pacientes y se identificó y registró la presencia de una espirometría en todos los pacientes, clasificando los pacientes en 3 grupos: pacientes con una espirometría con datos de obstrucción (EPOC confirmada), pacientes sin espirometría realizada o registrada (EPOC no confirmada) y los pacientes con espirometría sin patrón espirométrico (sobrediagnóstico).

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 3.094 Quartil: 3 Categoria: Infectious Diseases Posició: 68/95

Network. Coronavirus disease 2019 hospitalization outcomes in persons with and without HIV in Spain. AIDS. 2022 Apr 1;36(5):683-690. doi: 10.1097/QAD.0000000000003056. PMID: 35323157.

Abstract:

Objective: To compare coronavirus disease 2019 (COVID-19) hospitalization outcomes between persons with and without HIV.

Design: Retrospective observational cohort study in 150 hospitals in Spain. Methods: Patients admitted from 1 March to 8 October 2020 with COVID-19 diagnosis confirmed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 positive) PCR test in respiratory tract samples. The primary data source was the COVID-19 Sociedad Española de Medicina Interna's registry (SEMI-COVID-19). Demographics, comorbidities, vital signs, laboratory parameters, and clinical severity as well as treatments received during admission, treatment duration, ICU admission, use of invasive mechanical ventilation, and death were recorded. Factors associated with mortality and the composite of ICU admission, invasive mechanical ventilation, and death, were analyzed.

Results: Data from 16 563 admissions were collected, 98 (0.59%) of which were of persons with HIV infection. These patients were younger, the percentage of male patients was higher, and their Charlson comorbidity index was also higher. Rates of mortality and composite outcome of ICU admission, invasive mechanical ventilation or death were lower among patients with HIV infection. In the logistic regression analysis, HIV infection was associated with an adjusted odds ratio of 0.53 [95% confidence interval (CI) 0.29-0.96] for the composite outcome.

Conclusion: HIV infection was associated with a lower probability of ICU admission, invasive mechanical ventilation, or death.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.632 Quartil: 2 Categoria: Infectious Diseases Posició: 43/95

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Olalla-Sierra J, Martín-Escalante MD, García-Alegría J, Rubio-Rivas M, de Miguel-Campo B, Zurita-Etayo M, Arbones-Fernández L, Alcalá-Pedrajas JN, Roldán- Silvestre A, Cortés-Rodríguez B, Casas-Rojo JM, Núñez-Cortés JM; SEMI-COVID-19

Publicacions Científiques CSDM 2022

Gómez-Antúnez M, Recio-Iglesias J, Almagro P, Díez-Manglano J, López-García F, Boixeda R.

Impact of the iCODEX tool in routine clinical practice in Spain.

Curr Med Res Opin. 2022 Feb;38(2):181-187. doi: 10.1080/03007995.2021.2014162. Epub 2021 Dec 24. PMID: 34894948.

Abstract:

Introduction: The prognosis of COPD patients can be calculated using multidimensional indexes that improve the predictive capacity of the individual variables. The CODEX index can be calculated using iCODEX, a digital support tool available on the web and in an app. The aim of this study was to evaluate how the usefulness and applicability of iCODEX and its recommendations in routine clinical practice are perceived by specialists in internal medicine, pneumology, and primary care.

Methods: A cross-sectional study was conducted from November 2019 to February 2020 with the participation of specialists in internal medicine, primary care, and pneumology. All respondents completed a survey consisting of 104 questions on their perception of the iCODEX tool.

Results: Overall, 335 physicians responded. Of these, 95.2% had no difficulty accessing the tool and 83.1% were quite or very satisfied with it. Regarding the applicability and implementation of iCODEX recommendations in routine clinical practice, respondents reported that the recommendations were generally applicable: most questions obtained a median score of ≥ 4 out of 5. The recommendations with the greatest expected clinical benefit are listed.

Conclusions: Our study shows that the iCODEX tool is easy for participating specialists to use and identifies the recommendations that have the greatest clinical impact in areas such as lung obstruction, severe exacerbations, exercise, smoking, and patient follow-up.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.705 Quartil: 3 Categoria: Medicine, General & Internal Posició: 94/172

Dey M, Naveen R, Nikiphorou E, Sen P, Saha S, Lilleker JB, Agarwal V, Kardes S, Day J, Milchert M, Joshi M, Gheita T, Salim B, Velikova T, Edgar Gracia-Ramos A, Parodis I, O'Callaghan AS, Kim M, Chatterjee T, Tan AL, Makol A, Nune A, Cavagna L, Saavedra MA, Shinjo SK, Ziade N, Knitza J, Kuwana M, Distler O, Barman B, Singh YP, Ranjan R, Jain A, Pandya SC, Pilania RK, Sharma A, Manoj M M, Gupta V, Kavadichanda CG, Patro PS, Ajmani S, Phatak S, Goswami RP, Chowdhury AC, Mathew AJ, Shenoy P, Asranna A, Bommakanti KT, Shukla A, Pande AR, Chandwar K, Pauling JD, Wincup C, Üsküdar Cansu D, Zamora Tehozol EA, Rojas Serrano J, La Torre IG, Del Papa N, Sambataro G, Atzeni F, Govoni M, Parisi S, Bocci EB, Sebastiani GD, Fusaro E, Sebastiani M, Quartuccio L, Franceschini F, Sainaghi PP, Orsolini G, De Angelis R, Danielli MG, Venerito V, Traboco LS, Hoff LS, Kusumo Wibowo SA, Tomaras S, Langguth D, Limaye V, Needham M, Srivastav N, Yoshida A, Nakashima R, Sato S, Kimura N, Kaneko Y, Loarce-Martos J, Prieto-González S, Gil-Vila A, Aranega-Gonzalez R, Chinoy H, Agarwal V, Aggarwal R, Gupta L; COVAD Study Group.

Higher risk of short term COVID-19 vaccine adverse events in myositis patients with autoimmune comorbidities: results from the COVAD study.

Rheumatology (Oxford). 2022 Oct 25:keac603. doi: 10.1093/rheumatology/keac603. Epub ahead of print. PMID: 36282492

Abstract: Vaccination against coronavirus disease 2 (COVID-19) is known to reduce adverse infection outcomes in the general population. However, most COVID-19 vaccination studies have excluded immunosuppressed individuals and those with systemic autoimmune diseases (SAIDs), including idiopathic inflammatory myopathies (IIMs), leading to a lack of safety data for this patient group. Studies of self-reported adverse events (AEs) following vaccination against COVID-19 have yielded conflicting results, with either higher or comparable adverse events

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in IIMs versus healthy controls (HCs). This could potentially be explained by the effect of coexistent comorbidities on AEs in these patients, especially comorbid autoimmune conditions, an area that remains under-studied.

The COVID-19 Vaccination in Autoimmune Diseases (COVAD) study is an ongoing International collaborative study involving 106 countries and 152 investigators. It captures data including vaccination uptake, AEs, COVID infection and comorbidities in people with SAIDs, by means of an online survey. We previously reported a modest increase in the incidence of severe adverse events 7-day post-vaccination in 1227 patients with IIMs compared to 5033 HCs, as well as other SAIDs. Notably, adverse events were higher in the dermatomyositis (DM) group and active disease The COVAD study is currently in its second phase which captures data on the long-term efficacy of vaccines, vaccine-induced disease flares, de novo emergence of autoimmune diseases, effects of booster vaccine doses, and specific risks of antenatal vaccination. Patients with IIM often have multiple comorbidities, and the effects and burden of these comorbidities on patient-reported outcomes are seldom accounted for. We hypothesized that harboring multiple autoimmune comorbidities may influence post-vaccination AEs and outcomes. Therefore, we explored the influence of autoimmune multimorbidity (i.e. defined as 1 or more coexistent autoimmune diseases in patients with IIMs) on their self-reported AEs, and the effect of adjustment for these factors in the IIM-SAID group with IIMs alone HCs.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 7.046 Quartil: 1 Categoria: Rheumatology Posició: 6/34

Correlación de la proteína C reactiva determinada

y venosa en las infecciones del tracto respiratorio inferior.

Aten Primaria. 2022 Mar;54(3):102210. Spanish. doi: 10.1016/j.aprim.2021.102210. Epub 2022 Jan 13. PMID: 35033851; PMCID: PMC8762367.

Abstract:

Las infecciones del tracto respiratorio inferior (ITRI) son uno de los motivos más frecuentes de consulta en atención primaria (AP) y la bronquitis aguda de etiología viral representa la mayoría de estas infecciones respiratorias. En la práctica clínica, la diferenciación etiológica de la infección respiratoria entre vírica y bacteriana es compleja porque no existe ninguna combinación validada de síntomas y signos que aseguren el diagnóstico, lo que implica que una gran parte de estas infecciones sean tratadas con antibióticos, con la consiguiente contribución al desarrollo de resistencias bacterianas y la adición de efectos adversos para el paciente sin que se haya demostrado mejoría en la evolución de la infección. La proteína C reactiva (PCR), biomarcador de fase aguda que se eleva en sangre periférica a las 4-6 horas del inicio del proceso infeccioso4 ha demostrado utilidad para diferenciar entre procesos infecciosos y otros trastornos inflamatorios, así como para distinguir entre infecciones bacterianas de otras infecciones víricas e incluso diferenciar neumonía de otras causas de infección respiratoria aguda. La medición de este biomarcador en sangre capilar mediante test de diagnóstico rápido (TDR) en el mismo momento de la visita médica, podría tener utilidad para el manejo de este tipo de infecciones en las consultas de AP donde el acceso a pruebas complementarias es mucho más limitado que el medio hospitalario y se trabaja con gran incertidumbre diagnóstica. El objetivo principal de nuestro estudio fue determinar la correlación existente entre la concentración PCR en sangre capilar obtenida mediante TDR y la concentración de PCR en sangre venosa (gold standard) en pacientes afectos de ITRI para así poder inferir la posible utilidad de la aplicación de esta técnica en las consultas de AP.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.206 Quartil: 3 Categoria: Medicine, General & Internal Posició: 110/172

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Fernández Fernández EP, Almirall J, Pere T, Roca J, Boixeda R

en sangre capilar

Publicacions Científiques CSDM 2022

Arévalo-Lorido JC, Carretero-Gómez J, Casas-Rojo JM, Antón-Santos JM, Melero- Bermejo JA, López-Carmona MD, Palacios LC, Sanz-Cánovas J, Pesqueira-Fontán PM, de la Peña-Fernández AA, de la Sierra Alcántara NM, García-García GM, Torres Peña JD, Magallanes-Gamboa JO, Fernández-Madera-Martinez R, FernándezFernández J, Rubio-Rivas M, Maestro-de la Calle G, Cervilla-Muñoz E, Ramos-Martínez A, Méndez-Bailón M, Ramos-Rincón JM, Gómez-Huelgas R; SEMI-COVID-19 Network. The importance of association of comorbidities on COVID-19 outcomes: a Machine learning approach. Curr Med Res Opin. 2022 Apr;38(4):501-510. doi: 10.1080/03007995.2022.2029382. Epub 2022 Feb 1. PMID: 35037799

Abstract:

Background: The individual influence of a variety of comorbidities on COVID-19 patient outcomes has already been analyzed in previous works in an isolated way. We aim to determine if different associations of diseases influence the outcomes of inpatients with COVID-19.

Methods: Retrospective cohort multicenter study based on clinical practice. Data were taken from the SEMICOVID-19 Registry, which includes most consecutive patients with confirmed COVID-19 hospitalized and discharged in Spain. Two machine learning algorithms were applied in order to classify comorbidities and patients (Random Forest -RF algorithm, and Gaussian mixed model by clustering -GMM-). The primary endpoint was a composite of either, all-cause death or intensive care unit admission during the period of hospitalization. The sample was randomly divided into training and test sets to determine the most important comorbidities related to the primary endpoint, grow several clusters with these comorbidities based on discriminant analysis and GMM, and compare these clusters.

Results: A total of 16,455 inpatients (57.4% women and 42.6% men) were analyzed. According to the RF algorithm, the most important comorbidities were heart failure/atrial fibrillation (HF/AF), vascular diseases, and neurodegenerative diseases. There were six clusters: three included patients who met the primary endpoint (clusters 4, 5, and 6) and three included patients who did not (clusters 1, 2, and 3). Patients with HF/AF, vascular diseases, and neurodegenerative diseases were distributed among clusters 3, 4 and 5. Patients in cluster 5 also had kidney, liver, and acid peptic diseases as well as a chronic obstructive pulmonary disease; it was the cluster with the worst prognosis.

Conclusion: The interplay of several comorbidities may affect the outcome and complications of inpatients with COVID-19.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.705 Quartil: 3 Categoria: Medicine, General & Internal Posició: 94/172

The "FIFTY SHADOWS" of the RALES Trial: Lessons about the Potential Risk of Dietary Potassium Supplementation in Patients with Chronic Kidney Disease.

J Clin Med. 2022 Jul 8;11(14):3970. doi: 10.3390/jcm11143970. PMID: 35887733; PMCID: PMC9318835.

Abstract: Background: COVID-19 severely impacted older adults and long-term care facility (LTCF) residents. Our primary aim was to describe differences in clinical and epidemiological variables, in-hospital management, and outcomes between LTCF residents and community-dwelling older adults hospitalized with COVID-19. The secondary aim was to identify risk factors for mortality due to COVID-19 in hospitalized LTCF residents.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Romero-González G, Bover J, Arrieta J, Salera D, Troya M, Graterol F, Ureña-Torres P, Cozzolino M, Di Lullo L, Cippà PE, Urrutia M, Paúl-Martinez J, Boixeda R, Górriz JL, Ara J, Bayés-Genís A, Bellasi A, Ronco C.

Publicacions Científiques CSDM 2022

Methods: This is a cross-sectional analysis within a retrospective cohort of hospitalized patients ≥75 years with confirmed COVID-19 admitted to 160 Spanish hospitals. Differences between groups and factors associated with mortality among LTCF residents were assessed through comparisons and logistic regression analysis.

Results: Of 6 189 patients ≥75 years, 1 185 (19.1%) were LTCF residents and 4 548 (73.5%) were communitydwelling. LTCF residents were older (median: 87.4 vs 82.1 years), mostly female (61.6% vs 43.2%), had more severe functional dependence (47.0% vs 7.8%), more comorbidities (Charlson Comorbidity Index: 6 vs 5), had dementia more often (59.1% vs 14.4%), and had shorter duration of symptoms (median: 3 vs 6 days) than community-dwelling patients (all, p < .001). Mortality risk factors in LTCF residents were severe functional dependence (adjusted odds ratios [aOR]: 1.79; 95% confidence interval [CI]: 1.13-2.83; p = .012), dyspnea (1.66; 1.16-2.39; p = .004), SatO2 < 94% (1.73; 1.27-2.37; p = .001), temperature ≥ 37.8°C (1.62; 1.11-2.38; p = .013); qSOFA index ≥ 2 (1.62; 1.11-2.38; p = .013), bilateral infiltrates (1.98; 1.24-2.98; p < .001), and high C-reactive protein (1.005; 1.003-1.007; p < .001). In-hospital mortality was initially higher among LTCF residents (43.3% vs 39.7%), but lower after adjusting for sex, age, functional dependence, and comorbidities (aOR: 0.74, 95%CI: 0.62-0.87; p < .001).

Conclusion: Basal functional status and COVID-19 severity are risk factors of mortality in LTCF residents. The lower adjusted mortality rate in LTCF residents may be explained by earlier identification, treatment, and hospitalization for COVID-19.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.964 Quartil: 2 Categoria: Medicine, General & Internal Posició: 55/172

Rubio-Rivas

SEMI-COVID-19 Network.

Clusters of inflammation in COVID-19: descriptive analysis and prognosis on more than 15,000 patients from the Spanish SEMI-COVID-19 Registry.

Intern Emerg Med. 2022 Jun;17(4):1115-1127. doi: 10.1007/s11739-021-02924-4. Epub 2022 Mar 2. PMID: 35235131; PMCID: PMC8890024.

Abstract:

Uncontrolled inflammation following COVID-19 infection is an important characteristic of the most seriously ill patients. The present study aims to describe the clusters of inflammation in COVID-19 and to analyze their prognostic role. This is a retrospective observational study including 15,691 patients with a high degree of inflammation. They were included in the Spanish SEMI-COVID-19 registry from March 1, 2020 to May 1, 2021. The primary outcome was in-hospital mortality. Hierarchical cluster analysis identified 7 clusters. C1 is characterized by lymphopenia, C2 by elevated ferritin, and C3 by elevated LDH. C4 is characterized by lymphopenia plus elevated CRP and LDH and frequently also ferritin. C5 is defined by elevated CRP, and C6 by elevated ferritin and D-dimer, and frequently also elevated CRP and LDH. Finally, C7 is characterized by an elevated D-dimer. The clusters with the highest in-hospital mortality were C4, C6, and C7 (17.4% vs. 18% vs. 15.6% vs. 36.8% vs. 17.5% vs. 39.3% vs. 26.4%). Inflammation clusters were found as independent factors for inhospital mortality. In detail and, having cluster C1 as reference, the model revealed a worse prognosis for all other clusters: C2 (OR = 1.30, p = 0.001), C3 (OR = 1.14, p = 0.178), C4 (OR = 2.28, p < 0.001), C5 (OR = 1.07, p = 0.479), C6 (OR = 2.29, p < 0.001), and C7 (OR = 1.28, p = 0.001). We identified 7 groups based on the presence of lymphopenia, elevated CRP, LDH, ferritin, and D-dimer at the time of hospital admission for COVID-19. Clusters C4 (lymphopenia + LDH + CRP), C6 (ferritin + D-dimer), and C7 (D-dimer) had the worst prognosis in terms of inhospital mortality.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

M, Mora-Luján JM, Formiga F, Corrales González MÁ, García Andreu MDM, Moreno-Torres V, García García GM, Alcalá Pedrajas JN, Boixeda R, Pérez- Lluna L, Cortés-Rodríguez B, Mella-Pérez C, Navas Alcántara MS, López Reboiro ML, Alfaro-Lara V, Pérez-Martín S, Martín-Oterino JÁ, Gracia Gutiérrez A, Martín-Urda DíezCanseco A, Comas Casanova P, Pérez García C, Varona JF, Gómez-Huelgas R, Antón-Santos JM, LumbrerasBermejo C;

Publicacions Científiques CSDM 2022

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.472 Quartil: 2 Categoria: Medicine, General & Internal Posició: 46/172

Ramos-Rincón JM, Bernabeu-Wittel M, Fiteni-Mera I, López-Sampalo A, López- Ríos C, García-Andreu MD, Mancebo-Sevilla JJ, Jiménez-Juan C, Matía-Sanz M, López-Quirantes P, Rubio-Rivas M, Paredes-Ruiz D, GonzálezSan-Narciso C, González-Vega R, Sanz-Espinosa P, Hernández-Milián A, Gonzalez-Noya A, Gil- Sánchez R, Boixeda R, Alcalá-Pedrajas JN, Palop-Cervera M, Cortés-Rodríguez B, Guisado-Espartero ME, Mella-Pérez C, GómezHuelgas R; SEMI-COVID-19 Network.

Clinical Features and Risk Factors for Mortality Among Long-term Care Facility Residents Hospitalized Due to COVID-19 in Spain.

J Gerontol A Biol Sci Med Sci. 2022 Apr 1;77(4):e138-e147. doi: 10.1093/gerona/glab305. PMID: 34626477

Abstract:

Background: COVID-19 severely impacted older adults and long-term care facility (LTCF) residents. Our primary aim was to describe differences in clinical and epidemiological variables, in-hospital management, and outcomes between LTCF residents and community-dwelling older adults hospitalized with COVID-19. The secondary aim was to identify risk factors for mortality due to COVID-19 in hospitalized LTCF residents.

Methods: This is a cross-sectional analysis within a retrospective cohort of hospitalized patients ≥75 years with confirmed COVID-19 admitted to 160 Spanish hospitals. Differences between groups and factors associated with mortality among LTCF residents were assessed through comparisons and logistic regression analysis.

Results: Of 6 189 patients ≥75 years, 1 185 (19.1%) were LTCF residents and 4 548 (73.5%) were communitydwelling. LTCF residents were older (median: 87.4 vs 82.1 years), mostly female (61.6% vs 43.2%), had more severe functional dependence (47.0% vs 7.8%), more comorbidities (Charlson Comorbidity Index: 6 vs 5), had dementia more often (59.1% vs 14.4%), and had shorter duration of symptoms (median: 3 vs 6 days) than community-dwelling patients (all, p < .001). Mortality risk factors in LTCF residents were severe functional dependence (adjusted odds ratios [aOR]: 1.79; 95% confidence interval [CI]: 1.13-2.83; p = .012), dyspnea (1.66; 1.16-2.39; p = .004), SatO2 < 94% (1.73; 1.27-2.37; p = .001), temperature ≥ 37.8°C (1.62; 1.11-2.38; p = .013); qSOFA index ≥ 2 (1.62; 1.11-2.38; p = .013), bilateral infiltrates (1.98; 1.24-2.98; p < .001), and high C-reactive protein (1.005; 1.003-1.007; p < .001). In-hospital mortality was initially higher among LTCF residents (43.3% vs 39.7%), but lower after adjusting for sex, age, functional dependence, and comorbidities (aOR: 0.74, 95%CI: 0.62-0.87; p < .001).

Conclusion: Basal functional status and COVID-19 severity are risk factors of mortality in LTCF residents. The lower adjusted mortality rate in LTCF residents may be explained by earlier identification, treatment, and hospitalization for COVID-19

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Abstract:

La COVID-19, enfermedad causada por el SARS-CoV-2, se identificó en diciembre de 2019 y rápidamente progresó a una pandemia global. La edad y algunas comorbilidades, como la obesidad, las enfermedades cardiovasculares y la diabetes mellitus, se describieron en nuestro entorno como factores pronósticos de mala evolución y aumentaron el riesgo de hospitalización y muerte en las 2 primeras oleadas de la pandemia, antes de la vacunación. Además, los pacientes afectos de enfermedad oncohematológica, cáncer de pulmón o neoplasias en fases diseminadas demostraron un peor pronóstico. También se describió que los pacientes con neoplasias hematológicas en tratamiento con quimioterapia reciente eran los que tenían un mayor riesgo de mortalidad asociada a un ingreso por COVID-19 (OR 2,09; IC95%: 1,09-4,08; p = 0,028)4. Por último, la linfopenia, hallazgo muy frecuente en pacientes en tratamiento con quimioterapia o con fármacos biológicos, también se definió como un factor de mal pronóstico en la enfermedad por SARS-CoV-2.

A lo largo de la pandemia, los tratamientos se fueron modificando en función del conocimiento obtenido. Inicialmente la indicación de tratamiento específico se restringía a la infección grave que precisaba ingreso hospitalario. Debido a la aparición de las diferentes variantes del SARS-CoV-2 y a la implementación de la vacunación, superior al 80% de la población en Cataluña, a principios de 2022 se aprobó la indicación de tratamientos específicos para la enfermedad leve-moderada en pacientes con riesgo de progresión; entre ellos, los pacientes inmunodeprimidos.

En este momento se plantea el reto para los clínicos de adaptarse a este nuevo escenario: indicación de un tratamiento en la fase precoz de la enfermedad, en general en los 5 primeros días desde el inicio de los síntomas de la infección y una administración ambulatoria intravenosa de una sola dosis (sotromivab), 3 dosis (remdesivir) o, incluso, antivirales orales (nirmatrelvir/ritonavir). En este contexto, la existencia de protocolos y circuitos consensuados dirigidos a la prevención, detección precoz de la infección y tratamiento en los casos indicados con el mejor fármaco disponible puede contribuir a mejorar el manejo de estos pacientes. Para ello, parece imprescindible la creación de un grupo multidisciplinar que permita integrar el conocimiento de las enfermedades o tratamientos que puedan causar una inmunosupresión, la actualización de la indicación de tratamientos en estos pacientes de alto riesgo, las peculiaridades de la infección por SARS-CoV-2 y el conocimiento de la respuesta a la vacunación en estos pacientes

Indexat a: WOS/JCR Factor Impacte: 3.200 Quartil: 2 Categoria: Medicine. General & Internal Posició: 75/172

Abstract regimen), una vez al día, para una gran parte de nuestros pacientes. Todo ello favorece un seguimiento más relajado, con visitas semestrales o a veces incluso anuales. Asimismo, la reducción de la mortalidad asociada al VIH-SIDA ha comportado un envejecimiento de las personas viviendo con VIH; más de la mitad de esta población ha superado los 50 años. Ello se asocia a un aumento de la comorbilidad y la polifarmacia en la población VIH comparado con la población general de la misma edad. Esto puede llevar a tener que modificar el modelo asistencial actual de nuestros pacientes.

En los últimos años, la telemedicina ha empezado a tener cabida en el seguimiento de los pacientes con enfermedades crónicas, con el objetivo de mejorar tanto la atención médica como su calidad de vida. La telemedicina puede ser un modelo complementario que facilite la comunicación entre el paciente y el personal sanitario, mejorando la atención, a la vez que empoderando al paciente.

Sin embargo, estas ventajas han podido verse ensombrecidas en el momento actual, con la pandemia por el COVID-19. En concreto, en la infección crónica por el VIH, la situación actual ha obligado a sustituir la visita

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Abdulghani N, Burgos J, Cervantes M, Curran A, Dalmau D, Force L, Knobel H, Laguno M, Negredo E, Saumoy M. Nuevo paradigma, nuevo modelo de seguimiento del paciente con infección por VIH. Revista Multidisciplinar Sida. 2022; 10(26):23-28.

Publicacions Científiques CSDM 2022

presencial de muchos de nuestros pacientes por un nuevo modelo de visitas (videoconferencias, visitas telefónicas, etc.). Este cambio repentino en la asistencia, sin protocolos predefinidos ni herramientas adecuadas en muchas ocasiones, ha hecho que el seguimiento de nuestros pacientes con infección por el VIH haya sido, en cierto modo, desordenado e irregular, y a veces en detrimento de la calidad asistencial. Del mismo modo, este nuevo modelo de visitas no favorece el cambio proactivo de tratamiento a pautas menos complejas, más seguras o más adecuadas para el paciente. La inseguridad del facultativo a realizar cambios ante la incertidumbre de un seguimiento correcto o el hecho de no poder transmitir correctamente al paciente las peculiaridades del cambio, son algunos motivos que frenan los cambios proactivos. Ante esta situación, se plantea un nuevo reto. Pensamos que es necesario cambiar los modelos tradicionales de manejo de nuestros pacientes por otros más convenientes a la situación actual. Y por ello, proponemos un nuevo modelo de abordaje de nuestros pacientes para mejorar la calidad asistencial de los mismos en el momento actual.

Abstract:

En los últimos años las autoridades sanitarias, mundiales y nacionales, han establecido unos objetivos encaminados a disminuir los nuevos casos de infección por el VIH, a realizar un diagnóstico más precoz, y a cuidar a las personas que viven con el VIH (PVIH), para conseguir que se mantengan con una carga viral indetectable y con la mejor calidad de vida posible. Pero, aunque en nuestro país se ha avanzado mucho en este camino, algunos de estos objetivos no son todavía una realidad.

Actualmente la tasa global de nuevos diagnósticos del VIH en España, aunque se ha reducido respecto a décadas pasadas, sigue siendo superior a la media de la Unión Europea. Y, a pesar de que la prueba diagnóstica es gratuita y confidencial, el 45,9% de las personas diagnosticadas del VIH en 2019, todavía presentaba un diagnóstico del VIH tardío .

Por otra parte, el curso de la infección por el VIH/Sida ha sufrido un claro cambio desde que se dispone de un tratamiento antirretroviral (TAR) eficaz y hemos asistido a una importante reducción de la morbimortalidad y de la transmisión de la infección por el VIH. Este TAR ha evolucionado hasta unos niveles altísimos de eficacia, tolerancia y sencillez en el 80% de las personas que viven con el VIH.

Pero el escenario asistencial no es necesariamente más sencillo, ya que a la vez que sucede esto, nuestra población ha ido envejeciendo (el porcentaje de personas mayores de 50 años atendidas en los hospitales ha ido ascendiendo progresivamente desde el 12% en 2004 hasta el 55,4% en 2019) , y cada vez son más los pacientes con comorbilidades y polimedicación, por lo que resulta fundamental en este momento un abordaje multidisciplinar con la participación de los médicos de atención primaria (MAP), de los especialistas hospitalarios en VIH y de otros médicos de atención hospitalaria.

Estas realidades justifican un abordaje multidisciplinar y coordinado entre Atención Primaria (AP) y Atención Hospitalaria (AH), tanto para realizar tareas de prevención y cribado de la infección por el VIH en la población general, como para atender de forma integral los múltiples aspectos y matices que configuran esa atención, siempre intentando contemplar el principio de la medicina centrada en el paciente.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Alastrue I, Losa JE, Orozco N, Perez-Elias MJ, Ramon JL, Agusti Benito C, Abadia J, Alonso G, Arbizu L, Bachiller P, Barrerira I, Belda J, Barrufet P, Cabello A, Cabezas A, Caja L, Carrillo R, Cervero M, de la torre J, de los Santos I, Diaz de Santiago A, Diez A, Fanjul F, Flor ME, Flores J, Fuster MJ, Fuente V, Galera C, Galindo Mj, Garcia-Fraile LJ, Gimeno A, Gómez C, Hernandez J, Kortajaerena X, Lopez Bernaldo de Quiros JC, Macias J, Marco A, Martin L, Martinez J, Mascort J, Menendez A, Merino D, Mir C, Monsavo R, Navarro M, Nistal S, Orozco N, Ortega J, Peinado C, Perez JL, Portu J, Ramiro MA, Riera M, Rodriguez B, Romero A, Rubio R, Ryan P, Sanchez J, Sanchez Y, Santirso T, Sanz J, Serrano, R, Velasco M, Vera M, Zorzano C Manejo Compartido del Paciente con Infección por VIH entre Atención Primaria y Hospitalaria. Versión 1.0. –Febrero 2022. Disponible en: https://gesida-seimc.org/wp-content/uploads/2021/09/Documento_AP.pdf

Publicacions Científiques CSDM 2022

MOTILITAT DIGESTIVA –

GASTROINTESTINAL MOTILITY

Nº Articles indexats: 11 Factor Impacte total: 59.619 Factor d’impacte liderat: 41.487

Clavé P.

Economic evaluations of health care interventions in oropharyngeal dysphagia after stroke: protocol for a systematic review.

Syst Rev. 2022 May 14;11(1):92. doi: 10.1186/s13643-022-01969-6. PMID:35568891; PMCID: PMC9107184.

Abstract:

Background and purpose: Oropharyngeal dysphagia (OD) affects 40-81% of patients after stroke. A recent systematic review on the costs of OD and its main complications showed higher acute and long-term costs for those patients who developed OD, malnutrition and pneumonia after stroke. These results suggest that appropriate management of post-stroke OD could reduce clinical complications and costs. The purpose of this systematic review is to assess the available literature for healthcare interventions that are efficient or costeffective in the management of OD.

Methods: A systematic review on economic evaluations of health care interventions will be performed on poststroke patients with OD following PRISMA recommendations. Four bibliographic databases will be searched and a subsequent reference check will be done. English and Spanish literature will be included without date restrictions. Studies will be included if they refer to economic evaluations or in which cost savings were reported in post-stroke patients suffering OD. Studies will be excluded if they are partial economic evaluation studies, if they refer to esophageal dysphagia, or if OD is caused by causes different from stroke. Evidence will be presented and synthetised with a narrative method and using tables. Quality evaluation will be done using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement.

Discussion: The protocol for this systematic review is the first step to assess the cost-effectiveness of the healthcare interventions that have been described as potential treatments for post-stroke OD. This systematic review will summarise the current evidence on the relation between cost and benefits associated with the appropriate management of OD in post-stroke patients.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 3.136 Quartil: 2 Categoria: Medicine, General & Internal Posició: 80/172

Dysphagia: An Observational Study.

Dysphagia. 2022 Apr 23:1–11. doi: 10.1007/s00455-022-10451-3. Epub ahead of print. PMID: 35460440; PMCID: PMC9034075.

Abstract:

Oropharyngeal dysphagia (OD) is a frequent complication after stroke (PSOD) that increases morbidity and mortality. Early detection of PSOD is essential to reduce morbidity and mortality in patients with acute stroke. In recent years, an association between reduced spontaneous swallowing frequency (SSF) and OD has been described. Likewise, the reduction of saliva substance P (SP) concentration has been associated with an increased risk of aspiration and a decrease in SSF. In this study we aimed to compare SSF, salivary SP concentration, hydration and nutritional status in post-stroke (PS) patients with and without OD. We included 45 acute PS patients (4.98 ± 2.80 days from stroke onset, 62.22% men, 71.78 ± 13.46 year). The VolumeViscosity Swallowing Test (V-VST) was performed for clinical diagnosis of OD. SSF/minute was assessed through 10-min neurophysiological surface recordings including suprahyoid-electromyography and cricothyroidaccelerometry. Saliva samples were collected with a Salivette® to determine SP by ELISA. Hydration status was

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Marin S, Serra-Prat M, Ortega O,

Alvarez-Larruy M, Tomsen N, Guanyabens N, Palomeras E, Clavé P, Nascimento W. Spontaneous Swallowing Frequency in Post-Stroke Patients with and Without Oropharyngeal

Publicacions Científiques CSDM 2022

assessed by bioimpedance. Nutritional status was evaluated by Mini Nutritional Assessment Short Form (MNAsf) and blood analysis. Twenty-seven PS patients (60%) had OD; 19 (40%), impaired safety of swallow. SSF was significantly reduced in PSOD, 0.23 ± 0.18 and PSOD with impaired safety, 0.22 ± 0.18 vs 0.48 ± 0.29 swallows/minute in PS without OD (PSnOD); (both p < 0.005). Nutritional risk was observed in 62.92% PSOD vs 11.11% PSnOD (p = 0.007) and visceral protein markers were also significantly reduced in PSOD (p < 0.05). Bioimpedance showed intracellular dehydration in 37.50% PSOD vs none in PSnOD. There were no differences for saliva SP concentrations. SSF is significantly reduced in PSOD in comparison with PSnOD. Acute PSOD patients present poor nutritional status, hydropenia, and high risk for respiratory complications

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.733 Quartil: 2 Categoria: Otorhynolaryngology Posició: 15/43

The Hydration Status of

Effect of Thickened Fluid Therapy on Fluid Intake and Hydration: Results of Two Parallel Systematic and Scoping Reviews. Nutrients. 2022 Jun 16;14(12):2497. doi: 10.3390/nu14122497. PMID: 35745228; PMCID: PMC9228104.

Abstract:

Background: The effect of oropharyngeal dysphagia (OD) and thickened fluid (TF) therapy on hydration status has not been well defined in the literature. We aimed to assess the hydration status in patients with OD and the effect TF therapy has on it.

Methods: Two literature reviews following PRISMA methodology (each one including a systematic and a scoping review) were performed: (R1) hydration status in adult patients with OD; (R2) effect of TF therapy on fluid intake and dehydration. Narrative and descriptive methods summarized both reviews. Quality assessment was assessed by Joanna Briggs Institute tools and GRADE.

Results: (R1) Five out of twenty-two studies using analytical parameters or bioimpedance showed poorer hydration status among OD and 19-100% prevalence of dehydration; (R2) two high quality studies (total of 724 participants) showed positive effects of TF on hydration status. Among the articles included, nine out of ten studies that evaluated fluid intake reported a reduced TF intake below basal water requirements.

Conclusions: Dehydration is a highly prevalent complication in OD. There is scientific evidence on the positive effect of TF therapy on the hydration status of patients with OD. However, strict monitoring of fluid volume intake is essential due to the low consumption of TF in these patients. Indexat a: MEDLINE/WOS/JCR Factor Impacte: 6.706 Quartil: 1 Categoria: Nutrition & Dietetics Posició: 15/90

Food Hydrocoll. 2022;123:106960. doi: 10.1016/j.foodhyd.2021.106960

Abstract:

Thickening products (TPs) are a valid therapeutic strategy in patients with oropharyngeal dysphagia, their effect is mainly related to the bolus viscosity achieved. The aim of the study was to compare the information on the labels of 10 TPs of different thickening agents (hydrocolloids): modified starch-based, gum-based and mixtures. Viscosity was measured in SI units (mPa·s), using a rotational viscometer at 50 s−1 and 300 s−1, and the effect of oral amylase (α-SA) and shear thinning on the viscosity levels recommended by each manufacturer were

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Viñas P, Bolivar-Prados M, Tomsen N, Costa A, Marin S, Riera SA, Barcons N, Clavé P.

Adult Patients with Oropharyngeal Dysphagia and the

Publicacions Científiques CSDM 2022

assessed. Results were classified according to 3 textural classifications: National Dysphagia Diet (NDD), International Dysphagia Diet System (IDDSI) and Japanese Dysphagia Diet (JDD2013). Results are also presented in SI units (mPa·s) following a new proposed scientific labelling system developed in our laboratory at Hospital de Mataró and endorsed by eleven medical and scientific societies. The effect of α-SA was assessed after 30 s oral incubation of the thickened bolus. All TPs fulfil Food for Special Medical Purposes labelling regulations, use 3 thickness levels, and 70% use the NDD descriptors. Viscosities at 50 s−1 ranged between 75 and 350 mPa s for level 1, 256–1280 for level 2 and 377–6205 for level 3. α-SA caused 98–99% decrease in viscosity for modified starch-based TPs (MS) and 16% or even an increment for gum-based TPs. Shear thinning decreased viscosity from 40 to 60% for MS-based TPs and 70–75% for gum-based TPs. This study showed that TPs are commercialised using the same descriptors for very different viscosities when measured in mPa·s. Shear rate and α-SA strongly affect viscosity but this is not described on the labels. We claim labels should include viscosity in SI Units (mPa·s at 50 s−1) and the effect of αSA and shear thinning as main factors affecting the therapeutic effect and mode of action of thickening agents.

Indexat a: WOS/JCR

Factor Impacte: 11.504 Quartil: 1 Decil: 1 Categoria: Chemistry, Applied Posició: 3/72

Gels. 2022 Jul 9;8(7):430. doi: 10.3390/gels8070430. PMID: 35877515; PMCID: PMC9323126.

Abstract:

Besides shear viscosity, other texture parameters (adhesiveness or cohesiveness) might be relevant for safe swallowing in people suffering from oropharyngeal dysphagia. Shear viscosity is assessed through protocols developed using a viscometer or a rheometer. In contrast, protocols and instruments (capillary break-up rheometer) to assess adhesiveness and cohesiveness are less common and much less developed. Other equipment such as texture analyzers can provide useful information on food properties. Here, we aimed to explore different texture analyzer settings (type of test, probe, and protocol) to characterize four commercial dysphagia thickeners at the shear viscosity levels recommended by manufacturers. Among the tests used (extrusion or penetration) with the different probes (disc, cone and shape holder, sphere, or cylinder), cone extrusion provided information about adhesivity, disc extrusion about sample cohesiveness, and sphere about penetration and sample elasticity. The test speeds used influenced the results, but only one speed is needed as the different speeds provided the same fluid information; for easiness, it is proposed to use 1 mm/s. Comparing the texture analyzer results with viscosity values obtained at different shears, the texture analyzer parameters reflected information that differ from shear viscosity. This information could be relevant for the therapeutic effect of thickening products and food characterization.

Indexat a: WOS/JCR

Factor Impacte: 4.432 Quartil: 1 Categoria: Polymer Sicence Posició: 22/90

The Impact of Periventricular Leukoaraiosis in Post-stroke Oropharyngeal Dysphagia: A Swallowing Biomechanics and MRI-Based Study. Dysphagia. 2022 Aug 23. doi: 10.1007/s00455-022-10509-2. Epub ahead of print. PMID: 35997813

Abstract:

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Baixauli R, Bolivar-Prados M, Ismael-Mohammed K, Clavé P, Tárrega A, Laguna L.

Characterization of Dysphagia Thickeners Using Texture Analysis-What Information Can Be Useful?

Guanyabens N, Cabib C, Ungueti A, Duh M, Arreola V, Palomeras E, Fernández MT, Nascimento W, Clavé P, Ortega O

Publicacions Científiques CSDM 2022

Besides shear viscosity, other texture parameters (adhesiveness or cohesiveness) might be relevant for safe swallowing in people suffering from oropharyngeal dysphagia. Shear viscosity is assessed through protocols developed using a viscometer or a rheometer. In contrast, protocols and instruments (capillary break-up rheometer) to assess adhesiveness and cohesiveness are less common and much less developed. Other equipment such as texture analyzers can provide useful information on food properties. Here, we aimed to explore different texture analyzer settings (type of test, probe, and protocol) to characterize four commercial dysphagia thickeners at the shear viscosity levels recommended by manufacturers. Among the tests used (extrusion or penetration) with the different probes (disc, cone and shape holder, sphere, or cylinder), cone extrusion provided information about adhesivity, disc extrusion about sample cohesiveness, and sphere about penetration and sample elasticity. The test speeds used influenced the results, but only one speed is needed as the different speeds provided the same fluid information; for easiness, it is proposed to use 1 mm/s. Comparing the texture analyzer results with viscosity values obtained at different shears, the texture analyzer parameters reflected information that differ from shear viscosity. This information could be relevant for the therapeutic effect of thickening products and food characterization.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.733 Quartil: 2 Categoria: Otorhynolaryngology Posició: 15/43

Abstract:

NutriCOVer is a global research program sponsored by Nutricia to support initiatives in clinical investigation in 16 countries worldwide. The program's objective is to adapt nutritional care to the needs of patients with COVID-19 who have been discharged from the intensive care unit. In Spain - a reference country for the NutriCOVer program - three research projects are being carried out. These studies analyze the clinical course of COVID-19 patients from a nutritional point of view, evaluating relevant aspects such as the prevalence and evolution of malnutrition and sarcopenia (the NUTRICOVID study), the prevalence and impact of dysphagia (the COVID-19-DN-OD study), or changes in corporal composition measured through nutritional ultrasound and bioimpedance analysis (the NUTRIECOMUSCLE study). In this article, the principal investigators of the three projects discuss the steps taken to develop these studies in the context of a worldwide pandemic: from initial concept, study design, and patient recruitment to problems in the execution of the project in day-to-day practice and publication policies. Also, they offer some insights on the initial results and the implications which these studies may have for current clinical practice

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Olveira Fuster G, Clavé Civit P, Álvarez Hernández J, de la Cuerda Compés C, García Almeida JM, Joaquín Ortiz C. Investigación en nutrición clínica y generación de nuevas evidencias: el programa NutriCOVer. Nutr Hosp. 2022 Mar 29;38(Spec No1):37-45. Spanish. doi: 10.20960/nh.04068. PMID: 35137596.

Publicacions Científiques CSDM 2022

replacement therapy (NRT) and inhibitors of the nicotinic acetylcholine receptor, which is activated by nicotine. Common side effects of oral NRT products include hiccoughs, gastrointestinal disturbances and, most notably, irritation, burning and pain in the mouth and throat, which are the most common reasons for premature discontinuation of NRT and termination of cessation efforts. Attempts to reduce the unwanted sensory side effects are warranted, and research discovering the most optimal masking procedures is urgently needed. This requires a firm mechanistic understanding of the neurobiology behind the activation of sensory nerves and their receptors by nicotine. The sensory nerves in the oral cavity and throat express the so-called transient receptor potential (TRP) channels, which are responsible for mediating the nicotine-evoked irritation, burning and pain sensations. Targeting the TRP channels is one way to modulate the unwanted sensory side effects. A variety of natural (Generally Recognized As Safe [GRAS]) compounds interact with the TRP channels, thus making them interesting candidates as safe additives to oral NRT products. The present narrative review will discuss (1) current evidence on how nicotine contributes to irritation, burning and pain in the oral cavity and throat, and (2) options to modulate these unwanted side-effects with the purpose of increasing adherence to NRT. Nicotine provokes irritation, burning and pain in the oral cavity and throat. Managing these side effects will ensure better compliance to oral NRT products and hence increase the success of smoking cessation. A specific class of sensory receptors (TRP channels) are involved in mediating nicotine's sensory side effects, making them to potential treatment targets. Many natural (Generally Recognized As Safe [GRAS]) compounds are potentially beneficial modulators of TRP channels.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.825 Quartil: 1 Categoria: Public, Environmental & Occupational Health Posició: 45/210

A Comparative Study between the Three Waves of the Pandemic on the Prevalence of Oropharyngeal Dysphagia and Malnutrition among Hospitalized Patients with COVID-19. Nutrients. 2022 Sep 16;14(18):3826. doi:10.3390/nu14183826. PMID: 36145215; PMCID: PMC9502091.

Abstract:

Background: The phenotype of patients affected by COVID-19 disease changed between the waves of the pandemic. We assessed the prevalence of oropharyngeal dysphagia (OD), malnutrition (MN), and mortality between the first three waves of COVID-19 patients in a general hospital.

Methods: a prospective observational study between April 2020-May 2021. Clinical assessment for OD was made with the volume-viscosity swallowing test; nutritional assessment was performed consistent with GLIM criteria. A multimodal intervention was implemented in the second and third wave, including (a) texturized diets-fork mashable (1900 kcal + 90 g protein) or pureed (1700 kcal + 75 g protein), (b) oral nutritional supplements (500-600 kcal + 25-30 g protein), and (c) fluid thickening (250 mPa·s or 800 mPa·s).

Results: We included 205 patients (69.3 ± 17.6 years) in the 1st, 200 (66.4 ± 17.5 years) in the 2nd, and 200 (72.0 ± 16.3 years;) in the 3rd wave (p = 0.004). On admission, prevalence of OD was 51.7%, 31.3% and 35.1%, and MN, 45.9%, 36.8% and 34.7%, respectively; mortality was 10.7%, 13.6% and 19.1%. OD was independently associated with age, delirium, and MN; MN, with age, OD, diarrhea and ICU admission; mortality, with age, OD and MN. (4) Conclusions: Prevalence of OD, MN and mortality was very high among COVID-19 patients. OD was independently associated with MN and mortality. An early and proactive multimodal nutritional intervention improved patients' nutritional status

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 6.706 Quartil: 1 Categoria: Nutrition & Dietetics Posició: 15/90

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Viñas P, Martín-Martínez A, Alarcón C, Riera SA, Miró J, Amadó C, Clavé P, Ortega O

Publicacions Científiques CSDM 2022

A Comparative Study on the Effect of Acute Pharyngeal Stimulation with TRP Agonists on the Biomechanics and Neurophysiology of Swallow Response in Patients with Oropharyngeal Dysphagia.

Int J Mol Sci. 2022 Sep 15;23(18):10773. doi: 10.3390/ijms231810773. PMID: 36142680; PMCID: PMC9506471.

Abstract:

Fluid thickening is the main compensatory strategy for patients with oropharyngeal dysphagia (OD) associated with aging or neurological diseases, and there is still no pharmacological treatment. We aimed to compare the effects of increasing bolus viscosity with that of acute stimulation with TRPV1, TRPA1 or TRPM8 agonists on the biomechanics and neurophysiology of swallow response in patients with OD. We retrospectively analyzed seven studies from our laboratory on 329 patients with OD. The effect of increasing shear viscosity up to 3682 mPa·s was compared by videofluoroscopy and pharyngeal sensory evoked potentials (pSEP) with that of adding to the bolus: capsaicin (TRPV1, 150 μM/10 μM), piperine (TRPA1/V1, 1 mM/150 μM), menthol (TRPM8, 1 mM/10 mM), cinnamaldehyde-zinc (TRPA1, 100 ppm-70 mM), citral (TRPA1, 250 ppm) or citral-isopulegol (TRPA1-TRPM8, 250 ppm-200 ppm). Fluid thickening improved the safety of swallow by 80% (p &lt; 0.0001) by delaying bolus velocity by 20.7 ± 7.0% and time to laryngeal vestibule closure (LVC) by 23.1 ± 3.7%. Capsaicin 150μM or piperine 1 mM significantly improved safety of swallow by 50% (p &lt; 0.01) and 57.1% (p &lt; 0.01) by speeding time to LVC by 27.6% (p &lt; 0.001) and 19.5% (p &lt; 0.01) and bolus velocity by 24.8% (p &lt; 0.01) and 16.9% (p &lt; 0.05), respectively. Cinnamaldehyde-zinc shortened the P2 latency of pSEPs by 11.0% (p &lt; 0.01) and reduced N2-P2 amplitude by 35% (p &lt; 0.01). In conclusion, TRPV1 and TRPV1/A1 agonists are optimal candidates to develop new pharmacological strategies to promote the recovery of brain and swallow function in patients with chronic OD.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 6.208 Quartil: 1 Categoria: Biochemistry & Molecular Biology Posició: 69/297

Yoshimatsu

Development

implementation of an aspiration pneumònia cause investigation algorithm. Clin Respir J. 2022 Nov 14. doi: 10.1111/crj.13557. Epub ahead of print. PMID: 36373578.

Abstract: The diagnostic criteria of aspiration pneumonia have not been established, and it remains an underdiagnosed entity. Diagnosis and cause investigation is essential in improving the management of aspiration pneumonia. The Japanese Respiratory Society Guidelines for the Management of Pneumonia in Adults (JRS Guidelines) show a list of risk factors for aspiration pneumonia. We developed an algorithm to aid physicians in evaluating these possible underlying factors and guide their management with a focus on aspiration pneumonia. The algorithm was developed based on the JRS Guidelines. The algorithm suggested dysphagia screening, pneumococcal and influenza vaccination, and other preventative measures for pneumonia. The algorithm was implemented in the acute setting of a general hospital among older patients admitted with pneumonia. Their outcomes were compared with a historical control group constituting similar patients from the previous year. Forty patients with pneumonia were assessed with the algorithm group, and 44 patients were included in the control group. In the algorithm group, significantly more cases (95.0% vs. 15.9%, p < 0.01) underwent early screening for a swallowing disorder. Two patients in the algorithm group were diagnosed with a new condition causing aspiration pneumonia, as opposed to none in the control group. Drugs with a potential risk for aspiration were identified and discontinued in 27.5% of the patients in the algorithm group and 4.5% in the control group. In conclusion, an aspiration pneumonia cause investigation algorithm translating the JRS guideline approach into practice enhanced the rate of swallow screening and preventative measures for aspiration.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Tomsen N, Ortega O, Alvarez-Berdugo D, Rofes L, Clavé P.

Y, Tobino K, Ortega O, Oda H, Ota H, Kawabata T, Hiramatsu Y, Murakami Y, Clavé P.

and

Publicacions Científiques CSDM 2022

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 1.761 Quartil: 4 Categoria: Respiratory System Posició: 63/66

Nutrients. 2022; 14(23):5028. https://doi.org/10.3390/nu14235028.

Abstract:

Increasing shear viscosity (ShV) in thickening products (TP) is a valid therapeutic strategy for oropharyngeal dysphagia (OD). However, salivary amylase in the oral phase and shear rate in the pharyngeal phase of swallowing can change the viscosity of TPs when swallowed. This study aims to design and validate a rheological protocol to reproduce the oral and pharyngeal factors that affect the therapeutic effect of TPs and report the viscosity measurements in a standardized scientific and precise manner. We measured (a) the variability of the ShV measurements across several laboratories; (b) the in vitro and ex vivo properties of TPs and (c) the impact of the X-ray contrast Omnipaque, temperature and resting time on the rheological properties of TPs. A common protocol was applied in four international laboratories to assess five ShV values (100, 200, 400, 800 and 1600 mPa·s) for the xanthan-gum TP Tsururinko Quickly (TQ). The protocol included the dose (g/100 mL water), stirring procedure and standing time before measurement. Each value was characterized at the shear rate of 50 and 300 s−1 pre- and post-oral incubation in eight volunteers. The effect of temperature, standing time and Omnipaque was assessed. The main results of the study were: (a) The mean intra-laboratory variability on the ShV at all levels was very low: 0.85%. The mean inter-laboratory variability was higher: 9.3%; (b) The shear thinning of TQ at 300 s−1 was 75–80%. Increasing the temperature or standing time did not affect the ShV, and oral amylase caused a small decrease; (c) Omnipaque slightly decreased the dose of TP and hardly affected the amylase resistance or shear thinning. This study showed that different laboratories can obtain very accurate and similar ShV measurements using this protocol which uses scientific, universal SI units (mPa·s). Our protocol accurately reproduces oral and pharyngeal factors affecting the therapeutic effect of TPs. The addition of X-ray contrast did not produce significant changes.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Bolivar-Prados M, Tomsen N, Hayakawa Y, Kawakami S, Miyaji K, Kayashita J, Clavé P

Proposal for a Standard Protocol to Assess the Rheological Behavior of Thickening Products for Oropharyngeal Dysphagia.

Publicacions Científiques CSDM 2022

new pulmonary infiltrates. The initial diagnostic impression was exacerbation of ILD due to probable res-piratory infection, so antibiotic treatment with antipseudomonal coverage began and corticosteroid therapy was increased. Subsequently, on examination, vesicular, hemorrhagic, bul-lous, and crusted lesions were observed on the right upper armand chest, without dermatomal distribution, suggestive of disseminated cutaneous herpes zoster, so intravenous acy-clovir was initiated. Given the suspicion of varicella zoster virus(VZV) pulmonary involvement, a pharyngeal smear PCR was per-formed that was positive for VZV, giving a diagnosis of bilateral VZV pneumonia. Despite antiviral treatment, fever persisted andacute phase reactant levels increased, so fiberoptic bronchoscopy was performed. Pseudomonas aeruginosa was isolated from the bronchial aspirate, so the same antibiotic treatment was main-tained. Despite treatment, the patient’s progress was poor withradiological progression and respiratory worsening, and he finallydied. Reactivation VZV pneumonia is a rare but fatal complication inpatients with ILD. Early diagnosis from skin lesions can be vital.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 6.333 Quartil: 1 Categoria: Respiratory System Posició: 14/66

González J, Carmona P, Gracia-Lavedan E, Benítez ID, Antón A, Balaña A, Díaz SB, Bernadich Ò, Córdoba A, Embid C, Espallargues M, Luján M, Martí S, Ortega Castillo MP, Tárrega J, Barbé F, Escarrabill J; CatCoVer group.

Cluster Analysis of Home Mechanical Ventilation in COPD Patients: A Picture of the Real World and Its Impact on Mortality.

Arch Bronconeumol. 2022 Jan 12:S0300-2896(22)00013-8. English, Spanish. doi: 10.1016/j.arbres.2021.12.015. Epub ahead of print. PMID: 35312537

Abstract

Background: Treatment of chronic hypercapnic failure in COPD patients with home noninvasive ventilation (HNIV) remains unclear.

Aim: To create a curated cohort of all COPD patients on HNIV in Catalonia, perform a cluster analysis, and evaluate mortality evolution.

Study design and methods: This study was a multicenter, observational study including all COPD patients on HNIV on 1st January of 2018. Patients were selected through the Catalan Health Service, and administrative and clinical data were obtained in the previous four years. Principal component analysis of mixed data and hierarchical clustering were performed to identify clusters of patients. Mortality was evaluated from 1 January 2018 until 31 December 2020.

Results: A total of 247 patients were enrolled. They were mostly male (78.1%), with a median (SD) age of 70.4 (9.4) years old. In 60%, 55% and 29% of patients, obesity, sleep apnea and heart failure coexisted, respectively. Cluster analysis identified four well-differentiated groups labeled for their clinical characteristics: (1) obese smokers, (2) very severe COPD, (3) sleep apnea and (4) older comorbid males. Patients belonging to Clusters (2) and (4) had a worse prognosis than patients in Clusters (1) and (3).

Interpretation: A high heterogeneity in the prescription of HNIV was demonstrated. Cluster analysis identifies four different groups, of which only one had COPD as the main cause of ventilation, while the other three clusters showed a predominance of other comorbidities. This leads to different survival outcomes, including an overlapping phenotype of obesity-related disease and sleep apnea with better survival

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 6.333 Quartil: 1 Categoria: Respiratory System Posició: 14/66

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Narváez J, Aburto M, Seoane-Mato D, Bonilla G, Acosta O, Candelas G, Cano- Jiménez E, Castellví I, GonzálezRuiz JM, Corominas H, López-Muñiz B, Martín- López M, Robles-Pérez A, Mena-Vázquez N, Rodríguez-Portal JA,

Publicacions Científiques CSDM 2022

Screening criteria for interstitial lung disease associated to rheumatoid arthritis: Expert proposal based on Delphi methodology.

Reumatol Clin (Engl Ed). 2022 Jun 23:S2173-5743(22)00095-8. doi: 10.1016/j.reumae.2021.12.003. Epub ahead of print. PMID: 35753951

Abstract

Objective: To develop a joint proposal for screening criteria of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) and vice versa, which serves as a guidelines in patient referral between the Rheumatology and Pneumology departments to early detection of these patients.

Methods: A systematic literature review was carried out on the risk factors for the development of ILD in RA patients, and for the referral criteria to Rheumatology for suspected early RA. Based on the available evidence, screening criteria were agreed using the Delphi method by a panel of pneumologists and rheumatologists with expertise in these pathologies.

Results: Screening criteria for ILD in patients with RA and for the early detection of RA in cases with ILD of unknown etiology have been developed. In both cases, a detection strategy was based on clinical risk factors. Recommendations also included the complementary tests to be carried out in the different clinical scenarios and on the periodicity that screening should be repeated.

Conclusion: A selective screening strategy is recommended for the first time in the early diagnosis of patients with ILD-RA. This multidisciplinary proposal aims to solve some common clinical questions and help decisionmaking, although its usefulness to identify these patients with good sensitivity must be confirmed in a validation study.

Indexat a: MEDLINE/WOS

Abstract

Background: Acute ischemic stroke patients not referred directly to a comprehensive stroke center (CSC) have reduced access to endovascular treatment (EVT). The RACECAT trial is a population-based cluster-randomized trial, designed to compare mothership and drip-and-ship strategies in acute ischemic stroke patients outside the catchment area of a CSC.

Aims: To analyze the evolution of performance indicators in the regions that participated in RACECAT.

Methods: This retrospective longitudinal observational study included all stroke alerts evaluated by emergency medical services in Catalonia between February 2016 and February 2020. Cases were classified geographically according to the nearest SC: local SC (Local-SC) and CSC catchment areas. We analyzed the evolution of EVT rates and relevant workflow times in Local-SC versus CSC catchment areas over three study periods: P1

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Ortiz AM, Sabater-Abad C, Castrejón I, Dos Santos R, Garrote-Corral S, Maese J, Silva-Fernández L, Castañeda S, Valenzuela C.

Publicacions Científiques CSDM 2022

(February 2016 to April 2017: before RACECAT initiation), P2 (May 2017 to September 2018), and P3 (October 2018 to February 2020).

Results: We included 20603 stroke alerts, 10,694 (51.9%) of which were activated within Local-SC catchment areas. The proportion of patients receiving EVT within Local-SC catchment areas increased (P1 vs. P3: 7.5% (95% confidence interval (CI), 6.4-8.7) to 22.5% (95% CI, 20.8-24.4) p < 0.001). Inequalities in the odds of receiving EVT were reduced for patients from CSC versus Local-SC catchment areas (P1: odds ratio (OR) 3.9 (95% CI, 3.2-5) vs. P3: OR 1.5 (95% CI, 1.3-1.7) In Local-SC, door-to-image (P1: 24 (interquartile range (IQR) 15-36), P2: 24 (15-35), P3: 21 (13-32) min, p < 0.001) and door-to-needle times (P1: 42 (31-60), P2: 41 (29-58), P3: 35 (25-50) p < 0.001) reduced. Time from Local-SC arrival to groin puncture also decreased over time (P1: 188 [151-229], P2: 190 (157-233), P3: 168 (127-215) min, p < 0.001).

Conclusion: An increase in EVT rates in Local-SC regions with a significant decrease in workflow times occurred during the period of the RACECAT trial.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 6.948 Quartil: 1 Categoria:

Neurology Posició: 25/212

Neurologia (Engl Ed). 2022 Jul 13:S2173-5808(22)00074-8. doi: 10.1016/j.nrleng.2020.10.012. Epub ahead of print. PMID: 35842129.

Abstract

Introduction: Ischaemic stroke (IS) due to cervical and cerebral artery dissection (CAD) is a rare entity, and few data are available on the use of such reperfusion therapies as intravenous fibrinolysis and mechanical thrombectomy in these patients. We analysed the use of these treatments in patients with IS due to CAD and compared them against patients receiving reperfusion treatment for IS of other aetiologies.

Methods: We conducted an observational, retrospective, multicentre study of patients with IS due to CAD recorded in the National Stroke Registry of the Spanish Society of Neurology during the period 2011-2019. Comparative analyses were performed between: a) patients with CAD treated and not treated with reperfusion therapies and b) patients treated with reperfusion for IS due to CAD and patients treated with reperfusion for IS due to other causes. Epidemiological data, stroke variables, and outcomes at discharge and at 3 months were included in the analysis.

Results: The study included 21,037 patients with IS: 223 (1%) had IS due to CAD, of whom 68 (30%) received reperfusion treatment. Reperfusion treatments were used less frequently in cases of vertebral artery dissection and more frequently in patients with carotid artery occlusion. Compared to patients with IS due to other causes, patients with CAD were younger, more frequently underwent mechanical thrombectomy, and less frequently received intravenous fibrinolysis. Rates of haemorrhagic complications, mortality, and independence at 3 months were similar in both groups.

Conclusions: Reperfusion therapy is frequently used in patients with IS due to CAD. The outcomes of these patients demonstrate the efficacy and safety of reperfusion treatments, and are comparable to the outcomes of patients with IS due to other aetiologies

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.486 Quartil: 1 Categoria: Clinicla Neurology Posició: 46/212

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Clinical

Campo-Caballero D, de la Riva P, de Arce A, Martínez-Zabaleta M, Rodríguez-Antigüedad J, Ekiza J, Iruzubieta P, Purroy F, Fuentes B, de Lera Alfonso M, Krupinski J, Mengual Chirife JJ, Palomeras E, Guisado-Alonso D, Rodríguez-Yáñez M, Ustrell X, Tejada García J, de Felipe Mimbrera A, Paré-Curell M, Tembl J, Cajaraville S, Garcés M, Serena J.

Reperfusion therapy in acute ischaemic stroke due to cervical and cerebral artery dissection: results from a Spanish multicentre study.

Publicacions Científiques CSDM 2022

Food borne-botulism during SARS- CoV-2 pandemic time. A case and a possible familial outbreak in Barcelona. Rev Neurol. 2022 Aug 1;75(3):71-74. Spanish, English. doi: 10.33588/rn.7503.2021294. PMID: 35879883.

Abstract

Introduction: Botulism is a potentially fatal neuroparalytic syndrome caused by Clostridium botulinum neurotoxin. The 25% are food-borne botulism cases.

Case report: We describe a confirmed case of botulism attended in our hospital in September 2020, together with a second case in a patient's relative, suspected but not confirmed by laboratory tests. Clinical presentation consisted on general weakness, bilateral cranial palsy, mydriasis, and rapidly progressive tetraparesis in case 1, involving respiratory and swallowing function so she required hospitalization and support treatment. Non specific and transient symptoms occurred in case 2. SARS-CoV-2 infection was initially suspected in both cases due to pandemic situation in our country, ruled out by negative PCR. When B neurotoxin was detected in stool sample of patient 1 we confirmed the diagnosis of food-borne botulism probably linked to home-made conserved beans.

Conclusion: Early clinical suspicion, together with laboratory and electromyography findings, and support treatment provided at hospital were crucial for favourable outcome. Being aware of this rare syndrom might contribute to its better management.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 1.235 Quartil: 4 Categoria: Clinical Neurology Posició: 198/212

Gelpi E, Baiardi S, Nos C, Dellavalle S, Aldecoa I, Ruiz-Garcia R, Ispierto L, Escudero D, Casado V, Barranco E, Boltes A, Molina-Porcel L, Bargalló N, Rossi M, Mammana A, Tiple D, Vaianella L, Stoegmann E, Simonitsch-Klupp I, Kasprian G, Klotz S, Höftberger R, Budka H, Kovacs GG, Ferrer I, Capellari S, Sanchez-Valle R, Parchi P. Sporadic Creutzfeldt-Jakob disease VM1: phenotypic and molecular characterization of a novel subtype of human prion disease.

Acta Neuropathol Commun. 2022 Aug 17;10(1):114. doi: 10.1186/s40478-022-01415-7. PMID: 35978418; PMCID: PMC9387077.

Abstract

The methionine (M)-valine (V) polymorphic codon 129 of the prion protein gene (PRNP) plays a central role in both susceptibility and phenotypic expression of sporadic Creutzfeldt-Jakob diseases (sCJD). Experimental transmissions of sCJD in humanized transgenic mice led to the isolation of five prion strains, named M1, M2C, M2T, V2, and V1, based on two major conformations of the pathological prion protein (PrPSc, type 1 and type 2), and the codon 129 genotype determining susceptibility and propagation efficiency. While the most frequent sCJD strains have been described in codon 129 homozygosis (MM1, MM2C, VV2) and heterozygosis (MV1, MV2K, and MV2C), the V1 strain has only been found in patients carrying VV. We identified six sCJD cases, 4 in Catalonia and 2 in Italy, carrying MV at PRNP codon 129 in combination with PrPSc type 1 and a new clinical and neuropathological profile reminiscent of the VV1 sCJD subtype rather than typical MM1/MV1. All patients had a relatively long duration (mean of 20.5 vs. 3.5 months of MM1/MV1 patients) and lacked electroencephalographic periodic sharp-wave complexes at diagnosis. Distinctive histopathological features included the spongiform change with vacuoles of larger size than those seen in sCJD MM1/MV1, the lesion profile with prominent cortical and striatal involvement, and the pattern of PrPSc deposition characterized by a dissociation between florid spongiform change and mild synaptic deposits associated with coarse, patch-like deposits in the cerebellar molecular layer. Western blot analysis of brain homogenates revealed a PrPSc type 1 profile with physicochemical properties reminiscent of the type 1 protein linked to the VV1 sCJD subtype. In

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Casado-Ruiz V, Cano A, Suárez-López A, Muriana D, Guanyabens-Buscà N, Sanz-Cartagena P, Álvarez-Larruy M, Palomeras E.

Publicacions Científiques CSDM 2022

summary, we have identified a new subtype of sCJD with distinctive clinicopathological features significantly overlapping with those of the VV1 subtype, possibly representing the missing evidence of V1 sCJD strain propagation in the 129MV host genotype.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 7.581 Quartil: 1 Categoria: Neurosciences Posició: 37/275

Font MÀ, García-Sánchez SM, Mengual JJ, Mena L, Avellaneda C, Serena J, Valls-Carbó A, Chamorro Á, Ustrell X, Molina C, Cardona P, Guasch-Jiménez M, Purroy F, Rodríguez-Campello A, Palomeras E, Cocho D, Krupinski J, Cánovas D, García-Alhama J, Zaragoza J, Puiggròs E, Matos N, Aragonès JM, Costa X, Sanjurjo E, Pedroza C, Monedero J, Almendros MC, Rybyeva M, Carrión D, Díaz G, Barceló M, Jiménez-Fàbrega X, Salvat-Plana M, Elosúa R, Pérez de la Ossa N, Gómez-Choco M; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR Consortium).

Determinants and Trends of the Use of Intravenous Thrombolysis for Minor Stroke: A Population-Based Study, 2016 to 2020. Stroke. 2022 Aug 10:101161STROKEAHA122038996. doi: 10.1161/STROKEAHA.122.038996. Epub ahead of print. PMID: 35946402.

Abstract Background: We analyzed the main factors associated with intravenous thrombolysis (IVT) in patients with minor ischemic stroke.

Methods: Data were obtained from a prospective, government-mandated, population-based registry of stroke code patients in Catalonia (6 Comprehensive Stroke Centers, 8 Primary Stroke Centers, and 14 TeleStroke Centers). We selected patients diagnosed with ischemic stroke and National Institutes of Health Stroke Scale (NIHSS) ≤5 at hospital admission from January 2016 to December 2020. We excluded patients with a baseline modified Rankin Scale score of ≥3, absolute contraindication for IVT, unknown stroke onset, or admitted to hospital beyond 4.5 after stroke onset. The main outcome was treatment with IVT. We performed univariable and binary logistic regression analyses to identify the most important factors associated with IVT.

Results: We included 2975 code strokes; 1433 (48.2%) received IVT of which 30 (2.1%) had a symptomatic hemorrhagic transformation. Patients treated with IVT as compared to patients who did not receive IVT were more frequently women, had higher NIHSS, arrived earlier to hospital, were admitted to a Comprehensive Stroke Centers, and had large vessel occlusion. After binary logistic regression, NIHSS score 4 to 5 (odds ratio, 40.62 [95% CI, 31.73-57.22]; P<0.001) and large vessel occlusion (odds ratio, 16.39 [95% CI, 7.25-37.04]; P<0.001) were the strongest predictors of IVT. Younger age, female sex, baseline modified Rankin Scale score of 0, earlier arrival to hospital (<120 minutes after stroke onset), and the type of stroke center were also independently associated with IVT. The weight of large vessel occlusion on IVT was higher in patients with lower NIHSS.

Conclusions: Minor stroke female patients, with higher NIHSS, arriving earlier to the hospital, presenting with large vessel occlusion and admitted to a Comprehensive Stroke Centers were more likely to receive intravenous thrombolysis

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 10.170 Quartil: 1 Decil:1 Categoria: Clinical Neurology

Posició: 14/212

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Workflow times and outcomes in patients triaged for a

Ann Neurol. 2022 Aug 23. doi: 10.1002/ana.26489. Epub ahead of print. PMID: 36053966.

Abstract

Introduction: Current recommendations for regional stroke destination suggest that patients with severe acute stroke in non-urban areas should be triaged based on estimated transport time to referral thrombectomycapable center.

Methods: We performed a post-hoc analysis to evaluate the association of pre-hospital workflow times with neurological outcomes in patients included in the RACECAT trial. Workflow times evaluated were known or could be estimated before transport allocation. Primary outcome was the shift analysis on the modified Rankin score at 90 days.

Results: Among the 1369 patients included, the median time from onset to EMS evaluation, estimated transport time to thrombectomy-capable center and local stroke center, and estimated transfer time between centers were 65 minutes (interquartile ratio(IQR) 43-138), 61 minutes (IQR 36-80), 17 minutes(IQR 9-27) and 62 minutes(IQR 36-73), respectively. Longer time intervals from stroke onset to EMS evaluation were associated with higher odds of disability at 90 days in the local stroke center group (adjusted common odds ratio(acOR) for each 30 minutes increment, 1.03, 95% CI 1.01-1.06), with no association in the thrombectomy-capable center group(acOR for each 30 minutes increment, 1.01, 95% CI 0.98-1.01)(pinteraction =0.021). No significant interaction was found for other pre-hospital workflow times. In patients evaluated by EMS later than 120 minutes after stroke onset, direct transport to a thrombectomy-capable center was associated with better disability outcomes(acOR 1.49, 95% CI 1.03- 2.17).

Conclusion: We found a significant heterogeneity in the association between initial transport destination and neurological outcomes according to the elapse of time between stroke onset and EMS evaluation(ClinicalTrials.gov:NCT02795962).

a:

Gadolinium-enhanced brain lesions in multiple sclerosis relapse.

Neurologia (Engl Ed). 2022 Sep;37(7):557-563. doi: 10.1016/j.nrleng.2021.10.005. PMID: 36064284.

Abstract

Objective: To study the clinico-radiological paradox in multiple sclerosis (MS) relapse by analyzing the number and location of gadolinium-enhanced (Gd+) lesions on brain MRI before methylprednisolone (MP) treatment. Methods: We analyzed brain MRI from 90 relapsed MS patients in two Phase IV multicenter double-blind randomized clinical trials that showed the noninferiority of different routes and doses of MP administration. A 1.5- or 3-T brain MRI was performed at baseline before MP treatment and within 15 days of symptom onset. The number and location of Gd+ lesions were analyzed. Associations were studied using univariate analysis.

Results: Sixty-two percent of patients had at least 1 Gd+ brain lesion; the median number was 1 (interquartile range 0-4), and 41% of patients had 2 or more lesions. The most frequent location of Gd+ lesions was subcortical

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

García-Tornel Á, Seró L, Urra X, Cardona P, Zaragoza J, Krupinski J, Gómez- Choco M, Mas Sala N, Catena E, Palomeras E, Serena J, Hernandez-Perez M, Boned S, Olivé-Gadea M, Requena M, Muchada M, Tomasello A, Molina CA, Salvat-Plana M, Escudero M, Jimenez X, Davalos A, Jovin TG, Purroy F, Abilleira S, Ribó M, Perez de la Ossa N; RACECAT trial investigators.

suspected severe stroke.

Publicacions Científiques CSDM 2022

(41.4%). Gd+ brain lesions were found in 71.4% of patients with brainstem-cerebellum symptoms, 57.1% with spinal cord symptoms and 55.5% with optic neuritis (ON). Thirty percent of patients with brain symptoms did not have Gd+ lesions, and only 43.6% of patients had symptomatic Gd+ lesions. The univariate analysis showed a negative correlation between age and the number of Gd+ lesions (p=0.002).

Conclusion: Most patients with relapse showed several Gd+ lesions on brain MRI, even when the clinical manifestation was outside of the brain. Our findings illustrate the clinico-radiological paradox in MS relapse and support the value of brain MRI in this scenario.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.486 Quartil: 1

Categoria: Clinical Neurology Posició: 46/212

Stroke. 2022 Nov 3. doi: 10.1161/STROKEAHA.122.039090. Epub ahead of print. PMID: 36325911.

Abstract

Background: We studied the evolution over time of diffusion weighted imaging (DWI) lesion volume and the factors involved on early and late infarct growth (EIG and LIG) in stroke patients undergoing endovascular treatment (EVT) according to the final revascularization grade.

Methods: This is a prospective cohort of patients with anterior large artery occlusion undergoing EVT arriving at 1 comprehensive stroke center. Magnetic resonance imaging was performed on arrival (pre-EVT), <2 hours after EVT (post-EVT), and on day 5. DWI lesions and perfusion maps were evaluated. Arterial revascularization was assessed according to the modified Thrombolysis in Cerebral Infarction (mTICI) grades. We recorded National Institutes of Health Stroke Scale at arrival and at day 7. EIG was defined as (DWI volume post-EVT-DWI volume pre-EVT), and LIG was defined as (DWI volume at 5d-DWI volume post-EVT). Factors involved in EIG and LIG were tested via multivariable lineal models.

Results: We included 98 patients (mean age 70, median National Institutes of Health Stroke Scale score 17, final mTICI≥2b 86%). Median EIG and LIG were 48 and 63.3 mL in patients with final mTICI<2b, and 3.6 and 3.9 cc in patients with final mTICI≥2b. Both EIG and LIG were associated with higher National Institutes of Health Stroke Scale at day 7 (ρ=0.667; P<0.01 and ρ=0.614; P<0.01, respectively). In patients with final mTICI≥2b, each 10% increase in the volume of DWI pre-EVT and each extra pass leaded to growths of 9% (95% CI, 7%-10%) and 14% (95% CI, 2%-28%) in the DWI volume post-EVT, respectively. Furthermore, each 10% increase in the volume of DWI post-EVT, each extra pass, and each 10 mL increase in TMax6s post-EVT were associated with growths of 8% (95% CI, 6%-9%), 9% (95% CI, 0%-19%), and 12% (95% CI, 5%-20%) in the volume of DWI post-EVT, respectively.

Conclusions: Infarct grows during and after EVT, especially in nonrecanalizers but also to a lesser extent in recanalizers. In recanalizers, number of passes and DWI volume influence EIG, while number of passes, DWI, and hypoperfused volume after the procedure determine LIG

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 10.170

Quartil: 1 Decil:1 Categoria: Clinical Neurology

Posició: 14/212

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Hernández-Pérez M, Werner M, Remollo S, Martín C, Cortés J, Valls A, Ramos A, Dorado L, Serena J, Munuera J, Puig J, Pérez de la Ossa N, Gomis M, Carbonell J, Castaño C, Muñoz-Narbona L, Palomeras E, Domenech S, Massuet A, Terceño M, Davalos A, Millán M.

Early and Delayed Infarct Growth in Patients Undergoing Mechanical Thrombectomy: A Prospective, Serial MRI Study.

Publicacions Científiques CSDM 2022

OFTALMOLOGIA–OPHTALMOLOGY

Nº Articles indexats: 1 Factor Impacte total: 2.536 Factor d’impacte liderat: 2.536

Clavé L, Torrents A, Millan Ms. Visual Acuity at Various Distances and Defocus Curve: A Good Match. Photonics, 2022;9(2):85.

Abstract

The defocus curve (DC) has become the gold standard method for assessing the visual performance at different distances, and hence, to evaluate the depth of focus that is provided by modern presbyopia-compensating intraocular lenses that are used in cataract surgery. A former study, carried out by other authors, reported that the DC method, based on placing the chart at far distance and using trial negative lenses, underestimated the visual acuity that was measured by varying the test distance (VD) in pseudophakic patients. We have revisited the issue with pseudophakic subjects and have extended the study to include young phakic observers with their natural accommodation preserved. Our results show that both the VD and DC methods are equivalent in precision and accuracy and can be used indistinctly. However, the DC method is more practical in the clínics because it does not require further control of the chart positioning and illuminance

Indexat a: WOS/JCR

Factor Impacte: 2.536 Quartil: 3 Categoria: Optics Posició: 51/101

ONCOLOGIA

patients (2021). Clin Transl Oncol. 2022 Apr;24(4):724-732. doi: 10.1007/s12094-022-02800-3. Epub 2022 Mar 1. PMID: 35230619; PMCID: PMC8886704.

Abstract

Infections are still a major cause of morbi-mortality in patients with cancer. Some of these infections are preventable through specific measures, such as vaccination or prophylaxis. This guideline aims to summarize the evidence and recommendations for the prevention of infections in cancer patients, devoting special attention to the most prevalent preventable infectious disease. All the evidences will be graded according to The Infectious Diseases Society of America grading system.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 3.340 Quartil: 3 Categoria: Oncology Posició: 165/245

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Romeo

Multicenter Real-World Data of Subsequent Chemotherapy after Progression to PARP Inhibitors in a Maintenance Relapse Setting. Cancers (Basel). 2022 Sep 11;14(18):4414. doi: 10.3390/cancers14184414. PMID: 36139574; PMCID: PMC9497128

Abstract

Background: Despite impressive progression-free survival (PFS) results from PARP inhibitors (PARPi) in ovarian cancer, concerns about their effect on post-progression treatment outcomes have recently arisen, particularly when administered in the relapsed setting. Overlapping mechanisms of resistance between PARPi and platinum have been described, and optimal therapies upon progression to PARPi are unknown. We communicate realworld data (RWD) on outcomes of subsequent chemotherapy upon progression to PARPi used as maintenance in ovarian cancer relapses, particularly focusing on platinum rechallenge, according to BRCA status.

Methods: Data from high-grade serous or endometrioid ovarian cancer patients who received subsequent chemotherapy after progression to maintenance PARPi in the relapsed setting, in 16 Catalan hospitals between August 2016 and April 2021, and who were followed-up until July 2021, were included. Endpoints were overall response rate (ORR), and PFS and overall survival (OS) measured from the subsequent chemotherapy starting date

Results: 111 patients were included [46 (41.4%) presented pathological BRCA1/2 mutations, 8 (7.5%) in other homologous recombination-related genes]. Sixty-four patients (57.7%) had received two prior chemotherapy lines, including the one immediately prior to PARPi. PARPi were niraparib (n = 60, 54.1%), olaparib (n = 49, 44.1%), and rucaparib (n = 2, 1.8%). A total of 81 patients remained platinum-sensitive (PS population) after progression to PARPi (when progression-free interval [PFI] was &gt;6 months after the last cycle of prior platinum) [median PFI 12.0 months (interquartile range, IQR, 8.8-17.1)]. Of those, 74 were treated with subsequent platinum regimens, with the following results: ORR of 41.9%, median PFS (mPFS) of 6.6 months (95% CI 6-9.2), and median OS (mOS) of 20.6 months (95% CI 13.6-28.9). Analysis of these 74 patients according to BRCA status showed that PFIs for BRCA mutant and non BRCA-mutant patients were 13.6 [IQR11.2-22.2] and 10.3 [IQR 7.4-14.9] months, respectively (p = 0.010); ORR were 40.0% versus 43.6%, respectively; Rates of progression (as best response) to subsequent platinum were 45.7% versus 17.9%, respectively (p = 0.004); mPFS and mOS were 3.5 (95% CI 2.5-8.6) versus 7.5 months (95% CI 6.5-10.1, p = 0.03), and 16.4 (95% CI 9.3-27.5) versus 24.2 months (95% CI 17.2-NR, p = 0.036), respectively.

Conclusion: This is the largest series of real-world data on ovarian cancer patients retreated with platinum in the post-PARPi scenario, separately analyzing BRCA mutant and non-mutant patients, to our knowledge. In our platinum-sensitive population, rechallenge with platinum after progression upon PARPi in the 3rd or later lines for ovarian cancer relapses shows relevant ORR and similar PFS outcomes to historical series of the prePARPi era. However, BRCA mutant patients presented significantly higher rates of progression under subsequent platinum and worse survival outcomes associated with subsequent platinum than non-BRCA-mutant patients.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 6.575 Quartil: 1 Categoria: Oncology Posició: 60/245

Br J Cancer. 2022 Oct 26. doi: 10.1038/s41416-022-01991-4. Epub ahead of print. PMID: 36289372

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

M, Gil-Martín M, Gaba L, Teruel I, Taus Á, Fina C, Masvidal M, Murata P, Fernández-Plana J, Martínez A, Pérez C, García Y, Rodriguez V, Cros S, Parera M, Zanui M, Catot S, Pardo B, Plaja A, Esteve A, Barretina-Ginesta MP.

Rodriguez-Vida A, Maroto P, Font A, Martin C, Mellado B, Corbera A, Orrillo M, Reig O, Querol R, Rios-Hoyo A, Cano L, Alonso J, Martinez G, Galtes S, Taus A, Martinez-Garcia M, Juanpere N, Juan O, Bellmunt J. Safety and efficacy of avelumab plus carboplatin in patients with metastatic castration-resistant prostate cancer in an open-label Phase Ib study.

Publicacions Científiques CSDM 2022

Abstract

Background: Single-agent PD-1/PD-L1 inhibitors have shown limited efficacy in unselected mCRPC. The evidence of a survival benefit with sipuleucel-T and ipilimumab, provides a rationale to study further increasing immunogenicity in mCRPC through combinations.

Methods: Safety and efficacy avelumab plus carboplatin was investigated in a single-arm Phase Ib study in mCRPC, progressing to at least one taxane and one androgen-receptor inhibitor. The primary endpoint was safety. Secondary endpoints included PSA/radiographic responses, progression-free survival (PFS) and overall survival (OS). Germline/somatic mutation analysis was performed.

Results: In total, 26 patients were included. Patients were heavily pretreated: 76.9% received ≥3 and 42.3% ≥4 prior lines. A DNA damage repair (DDR) alteration was found in three patients (11.5%). The safety profile was acceptable with 73% Grade 3-4 treatment-related adverse events. PSA response rate ≥50% was seen in 7.7% of patients. The objective response rate was 17.6%, including one complete response (5.9%). Two of these responders had a known DDR alteration (one BRCA2, one ATM). The median response duration was 6 months. Median radiographic PFS was 6.6 months (95% CI 4.28-9.01), and median OS 10.6 months (95% CI 6.68-NR).

Conclusions: Avelumab plus carboplatin has an acceptable safety profile and was associated with a prolonged OS given the heavily pretreated population.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 9.082 Quartil: 1 Categoria: Oncology Posició: 37/245

PEDIATRIA– PEDIATRICS

Nº Articles indexats: 9 Factor Impacte total: 14.376 Factor d’impacte liderat: 11.999

Brunet-Garcia L

H,

Kaski

E. Noncompaction Cardiomyopathy, Sick Sinus Disease, and Aortic Dilatation: Too Much for a Single Diagnosis? JACC Case Rep. 2022 Mar 2;4(5):287-293. doi: 10.1016/j.jaccas.2022.01.013. PMID: 35257104

Abstract: HCN4 mutations have been reported in association with sick sinus syndrome. A more complex phenotype, including noncompaction cardiomyopathy and aortic dilatation, has recently emerged. We report 3 family members with the pathogenic p.Gly482Arg variant, emphasizing the importance of considering HCN4 mutations when this combination of features is encountered in clinical practice. (Level of Difficulty: Advanced).

Indexat a: PubMed

Garriga Ferrer-Bergua L,

Senra AM, Pérez Velasco C, Montero Valladares C, Collazo Vallduriola I, Moya Villanueva S, Velasco Zúñiga R, Pérez Alba M, de la Torre Espí M; en representación del Grupo de Trabajo de Enfermedades Infecciosas de la SEUP.

Rate of methicillin-resistant Staphylococcus aureus in pediatric emergency departments in Spain. An Pediatr (Engl Ed). 2022 Jul 1:S2341-2879(22)00142-9. doi: 10.1016/j.anpede.2021.06.015.Epub ahead of print. PMID: 35788335

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

, Odori A, Fell

Field E, Roberts AM, Starling L,

JP, Cervi

Borrull

Publicacions Científiques CSDM 2022

Abstract

Introduction: Staphylococcus aureus is a common germ in bacterial infections in children. The rate of methicillin-resistant S. aureus (MRSA) is increasing lately.

Objectives: The main aim is to know the rate of positive cultures to MRSA in Spanish pediatric emergency departments. The secondary aims are to analyse the risk factors for MRSA isolation (patient origin, history of hospitalization or surgery in the previous 90 days, antibiotherapy in the previous 60 days, presence of comorbidity, invasive devices, prior MRSA isolation) and to analyse the morbidity of these infections.

Methodology: Retrospective multicenter study (07/01/2017-06/30/2018) with review of patient histories with isolation of S. aureus in samples of any origin obtained in 8 pediatric emergency departments of the Infectious Diseases Working Group of the Spanish Society of pediatric Emergencies.

Results: During this period, S. aureus was detected in 403 patients (average age 75.8 ± 59.2 months; 54.8% male): 28.8% hospital-related infections (HRI) and 71.2% community-related infections (CRI). Overall, MRSA rate was 16.6% (95% CI: 13-20.2%); 18.1% in HRI and 16.2% in CRI (p > 0.05). The highest rates of MRSA were obtained in skin abscesses (29.3%, CI 95%: 21.8-36.8%), patients not born in Spain (52%; CI 95%: 32-72%) or patients with a previous MRSA infection (90%; CI 95% 71.4-100%). 167 (41%) patients were admitted, 12 (3%) had complications and 4 (1%) suffered sequels. There were no deaths.

Conclusions: The overall MRSA rate was one in 6 staphylococcal infections. Higher MRSA rates were detected in samples of suppurating skin injuries and in foreign children or in children with a history of previous MRSA infection. In suppurative skin lesions, early drainage is essential and the change to an antibiotic with MRSA coverage should be considered if the evolution is inadequate.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.377 Quartil: 3 Categoria: Pediatrics Posició: 77/130

Brunet

Cardiac Manifestations of Myotonic Dystrophy in a Pediatric Cohort.

Front Pediatr. 2022 Jun 9;10:910660. doi: 10.3389/fped.2022.910660. PMID: 35757141; PMCID: PMC9218560

Abstract

Myotonic dystrophy type 1 (DM1) is the most prevalent inherited neuromuscular dystrophy in adults. It is a multisystem disease with cardiac manifestations. Whilst these are well-defined in adults, there are scarce published data in the pediatric population. This study aimed to investigate the yield and progression of cardiac disease in pediatric DM1 patients, focusing on congenital DM1 (cDM1).

Methods: A retrospective observational study of all pediatric DM1 patients referred to our center (December 2000-November 2020) was conducted. Patients were classified into DM1 forms according to age of symptom onset and disease severity. Patients underwent clinical and cardiac evaluation with 12-lead ECG, transthoracic echocardiography and 24-h ECG Holter monitoring.

Results: 67 DM1 pediatric patients were included: 56 (83.6%) cDM1 and 11 (16.4%) non-cDM1. Median followup time of cDM1 patients was 8.0 [3.25-11.0] years. 49 (87.5%) cDM1 patients had baseline 12-lead ECG and 44 (78.6%) had a follow-up 12-lead-ECG, with a median follow-up time from diagnosis to baseline ECG of 2.8 [1.08.5] years and to follow-up ECG of 10.9 [5.7-14.2] years. Overall, 43 (87.8%) presented ECG abnormalities, most commonly in the form of asymptomatic conduction disease (n = 23, 46.9%), of which 21 (42.9%) had first degree atrioventricular block (1st AVB). There was an increase of prevalence from baseline to follow-up ECG in low QRS voltage (16.7%), poor R wave progression (13.9%), abnormal repolarisation (11.9%) and 1st AVB (7.6%). one patient (1.8%) underwent pacemaker implantation for syncope in the context of progressive conduction disease. No patients developed left ventricular systolic dysfunction. 4 (7.1%) cDM1 patients died during follow up, including three who died suddenly with no clear cause of death.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Garcia L, Hajra A, Field E, Wacher J, Walsh H, Norrish G, Manzur A, Muntoni F, Munot P, Robb S, Quinlivan R, Scoto M, Baranello G, Sarkozy A, Starling L, Kaski JP, Cervi E.

Publicacions Científiques CSDM 2022

Conclusions: This study is the first to analyse the prevalence and progression of ECG abnormalities in cDM1 pediatric patients. The high prevalence of abnormal findings, progressive changes and number of potentially associated events (1 pacemaker implantation and 3 unexplained sudden deaths) stresses the importance of systematic and continued cardiac evaluation of these patients.

Indexat a: PubMed/WOS/JCR

Factor Impacte: 3.569 Quartil: 2

Categoria: Pediatrics Posició: 38/130

J. Partial absence of the pericardium: Only an incidental finding? An Pediatr (Engl Ed). 2022 Jun;96(6):540-542. doi: 10.1016/j.anpede.2022.04.006. Epub 2022 May 13. PMID: 35570189

Brunet-Garcia L

Abstract

Absence of the pericardium (AoP) is a rare anomaly usually detected by chance. Its incidence is less than 1 case per 10 000 inhabitants.1 It is classified based on its extension (complete or partial) and position (left, right or bilateral), and complete left-sided defects are the most frequent form (70%).2, 3, 4 In 30%–50% of cases, AoP is associated with congenital heart defects such as tetralogy of Fallot, atrial septal defect, patent ductus arteriosus, mitral valve defects or sinus venosus defects with partial anomalous pulmonary venous drainage3 as well as pulmonary malformations, Marfan syndrome, VATER syndrome and Palliester–Killian syndrome.2 Although most cases are asymptomatic, patients with partial absence of the pericardium (PAoP) may experience chest pain, palpitations, syncope or even sudden death secondary to herniation of cardiac structures through the pericardial defect. We present 2 cases of incidental finding of AoP. The first corresponded to a patient referred at the age of 13 years due to abnormal position of the heart in the chest radiography (CXR). He was symptomatic and did not have any relevant personal or family history. The physical examination was normal. The electrocardiogram (ECG) (Fig. 1A) showed sinus bradycardia with right axis deviation (+112 °), incomplete right bundle branch block (IRBBB), slow R wave progression, nonspecific intraventricular conduction delay (QRS duration of 96 ms) and abnormal repolarization (inverted T waves in V1–V4, transitioning in V5 and positive in V6). The CXR showed lung interposition between the aorta and pulmonary artery (PA), leftward shift of the heart with no visible right heart border and lung interposition between the left diaphragm and the base of the left heart (Fig. 2A–B). After performing an echocardiogram, PAoP was suspected on account of the posterior and leftward shift of the apex, paradoxical septal motion and apparent dilatation of the right ventricle due to leftward cardiac displacement (Fig. 1C; Supplemental material Appendix B, videos 1 and 2). Computed tomography (CT) and magnetic resonance imaging (MRI) findings confirmed the diagnosis (Fig. 2C–E). His exercise test was normal. As the patient was asymptomatic, a conservative approach was chosen. He has remained asmptomatic with no complications after 7 years follow-up

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

, Carretero Bellon JM, Pérez-Casares A, Prada Martínez FH, Sánchez-de-Toledo

Brunet-Garcia

Publicacions Científiques CSDM 2022

Abstract

Idiopathic ventricular fibrillation (IVF) is diagnosed in out-of-hospital VF survivors after comprehensive investigations have excluded structural heart disease or inherited channelopathies. Current guidelines recommend clinical screening of first-degree relatives of IVF survivors, but this approach has not been validated in children. This study aimed to assess the yield of clinical cardiac screening in child first-degree relatives of IVF victims. A retrospective observational study was conducted of all consecutive pediatric first-degree relatives of IVF patients referred to our center between December 2007 and April 2020. Patients underwent systematic evaluation including medical and family history; 12-lead resting, signal-averaged, and ambulatory electrocardiogram (ECG); echocardiogram; exercise testing; cardiac magnetic resonance imaging; and ajmaline provocation testing. Sixty child first-degree relatives of 32 IVF survivors were included [median follow-up time of 55 months (IQR 27.0-87.0 months); 30 (50%) females]. Eight patients (13.3%) from 6 families (18.8%) received a cardiac diagnosis: long QT syndrome (n = 4); Brugada syndrome (n = 3); and dilated cardiomyopathy (n = 1). There were no deaths during follow-up. This study demonstrates a high yield of clinical screening for inherited cardiac disease in child first-degree relatives of IVF survivors. These findings highlight the variable expression of inherited cardiac conditions and the importance of comprehensive clinical evaluation in pediatric relatives, even when extensive investigations in the proband have not identified a clear etiology. Moreover, our results support the validity of the investigations proposed by current guidelines in family relatives of IVF survivors.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 1.838 Quartil: 3 Categoria: Pediatrics Posició: 96/130

Brunet-Garcia L, Prada Martínez FH, Sanchez-de-Toledo J, Carretero Bellón JM.

Massive Dilatation of the Ascending Aorta in a Patient With Generalized Arterial Calcification of Infancy. World J Pediatr Congenit Heart Surg. 2022 Oct 13:21501351221129188. doi: 10.1177/21501351221129188. Epub ahead of print. PMID:36226411

Abstract

We report a case of massive ascending aortic dilatation in a patient with generalized arterial calcification of infancy (GACI). He was found to carry compound heterozygous mutations in ABCC6 gene, previously associated with pseudoxanthoma elasticum, although recently linked to GACI. Our case confirms previous reports of a genotypic overlap between both entities.

Indexat a: MEDLINE/WOS

Brunet-Garcia L, Albujar M, Sanchez-de-toledo J, Carretero Bellon JM.

Chiari's network: A truly a benign entity?

An Pediatr (Engl Ed). 2022. doi: 10.1016/j.anpedi.2022.05.007.

Abstract

La red de Chiari (RC) es una delgada membrana adherida a la aurícula derecha secundaria a la regresión incompleta del seno venoso derecho. Aunque generalmente es una entidad benigna, la persistencia de RC se ha asociado a complicaciones cardiovasculares como arritmias supraventriculares, defectos del septo interauricular, tromboembolismos o cianosis.2,3 Su diagnóstico es habitualmente incidental. El tratamiento es conservador debido a la involución de la RC durante los primeros meses de vida. No obstante, algunos pacientes pueden precisar cirugía.

Presentamos cuatro neonatos con cianosis secundaria a persistencia de RC que condicionaba flujo de derecha dirigiendo el flujo de derecha a izquierda a través del foramen oval permeable (FOP). Un paciente también

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Epub 2022 June 21.

Publicacions Científiques CSDM 2022

presentó taquicardia supraventricular autolimitada, iniciándose tratamiento con flecainida oral. Tres pacientes evolucionaron favorablemente con desaparición de la cianosis coincidiendo con la reversión del shunt a través del FOP. Otro paciente precisó cirugía a los dos meses de vida por persistencia de cianosis y obstrucción de la válvula tricúspide por protrusión de la RC.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 2.377 Quartil: 3

Mid-aortic Syndrome in a Pediatric Cohort.

Categoria: Pediatrics Posició: 77/130

Pediatr Cardiol. 2022 Oct 28. doi: 10.1007/s00246-022-03036-2. Epub ahead of print. PMID: 36307565.

Abstract

Mid-aortic syndrome (MAS) is an uncommon condition characterized by severe narrowing of the abdominal aorta, usually involving visceral and renal arteries. Most patients are asymptomatic and typically present with incidental hypertension which might evolve into end-organ damage if untreated. Our aim was to review 8 new pediatric MAS cases. A retrospective observational study of all pediatric patients with MAS diagnosis (April 1992-November 2021) was conducted. Patients underwent systematic evaluation (medical and family history; 12-lead electrocardiogram; echocardiogram; angiography and/or computed tomography or magnetic resonance angiography). 8 pediatric patients with MAS were included. Median age at diagnosis was 2.6 [0.2-4.7] years; median follow-up time was 8.6 [6.6-10.0] years. 6/8 patients presented with incidental hypertension, 1/8 with heart murmur, and 1/8 with heart failure symptoms. All patients were on antihypertensive treatment. 1/8 patients underwent surgery and 7/8 an endovascular treatment. At the end of the study period, among the 6 patients that underwent a successful endovascular procedure, 2 achieved good blood pressure (BP) control, 2 acceptable BP control, 1 stage 1 hypertension and, another, stage 2 hypertension. There was 1 death during follow-up. BP monitoring in pediatric patients is crucial for early recognition of MAS. Treatment should be based on the individual clinical characteristics of patients with careful planning of surgical revascularisation, if possible, after adult growth is completed. Our study demonstrates that endovascular treatment might be a good alternative to surgery. Nevertheless, further trials with larger sample size and longer-term follow-up are required to determine the best treatment approach.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 1.838 Quartil: 3 Categoria: Pediatrics Posició: 96/130

Brunet-Garcia L, Zuccarino F,

Garrido BA,

Bellon JM. Interrupted Aortic Arch Associated With Aortopulmonary Window: The Role of Multidetector Computed Tomography Angiography.

World J Pediatr Congenit Heart Surg. 2022 Nov 4:21501351221133756. doi: 10.1177/21501351221133756. Epub ahead of print. PMID: 36330683.

Abstract

We report a case of a 2-day-old male with a diagnosis of interrupted aortic arch combined with aortopulmonary window suspected through echocardiography and confirmed by multidetector computer tomography (MDCT) angiography. Our case highlights how MDCT angiography was a key factor in planning surgical approach as it not only accurately defined aortic arch anatomy but also aortopulmonary window morphology

Indexat a: MEDLINE/WOS

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Brunet-Garcia L, Prada Martínez FH, Lopez Sainz A, Sanchez-de-Toledo J, Carretero Bellon JM.

Moscoso

Carretero

PSIQUIATRIA - PSYCHIATRY

Nº Articles indexats: 20 Factor Impacte total: 88.805 Factor d’impacte liderat: 37.7

Monreal JA,

N,

A,

M, Crespo JM, Nadal R, de Arriba-Arnau A, Massaneda C, Palao D, Menchón JM, Labad J, Soria V. The relationship between sex, personality traits, and the hypothalamic-pituitary-adrenocortical axis. Arch Womens Ment Health. 2022 Jun 23. doi: 10.1007/s00737-022-01241-9. Epub ahead of print. PMID: 35732898

Abstract

The aim of our study was to examine whether there are sex-based differences in the relationship between personality traits and hypothalamic-pituitary-adrenal (HPA) axis measures. A total of 106 healthy volunteers (56.6% women; age: 48.0 ± 15.8 years) were studied. The revised temperament and character inventory (TCI-R) and the Childhood Trauma Questionnaire (CTQ) were administered. HPA axis function was assessed using three dynamic measures: the cortisol awakening response (CAR), the diurnal cortisol slope, and the cortisol suppression ratio with 0.25 mg of dexamethasone (DSTR). Female sex was associated with an increased CAR and a more flattened diurnal cortisol slope, although a negative significant interaction between harm avoidance and female sex was found. Regarding the DSTR, perseverance was associated with increased cortisol suppression after dexamethasone; sex did not affect this association. Our study suggests that the relationship between specific personality traits (harm avoidance) and HPA axis measures (CAR, diurnal slope) differs according to sex.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.405 Quartil: 2 Categoria: Psychiatry (SCIE) Posició: 72/155

J

Abstract

Clozapine is seldom prescribed in treatment-resistant schizophrenia (TRS) patients during early phases of the illness. We aimed to examine the pathway and patterns and the impact of clozapine use in patients with TRS who were followed up for 10 years after the first outbreak of the illness. Data were obtained retrospectively from an epidemiological cohort of first episode schizophrenia patients (n = 218) who had been treated in a specialized intervention program (PAFIP). Out of 218, 35 (16%) individuals were on clozapine at 10-year assessment, while 183 (84%) were taking other antipsychotics. Among those 183 psychosis subjects who were not on clozapine, 13 (7.1%) met criteria for TRS. In the clozapine group, ten (28.6%) met criteria for early-TR and twenty-five (71.4%) met criteria for late-TR. Before clozapine treatment was initiated, the median number of days under other antipsychotic treatment was 1551 days (IQR = 1715) and the median time that subjects remained on clozapine was 6.3 years (IC95%: 5.49-7.20). At 10 years, we found that those individuals taking clozapine had higher CGI total scores (F = 12.0, p = 0.001) and SANS total scores (F = 9.27, p = 0.003) than subjects taking other antipsychotics after correcting for baseline values. Interestingly, when performing these analyses at 10 years between subjects taking clozapine (n = 35) and subjects who despite meeting TRS criteria were not taking clozapine (n = 13), we found that subjects taking clozapine had significantly lower total scores on all clinical scales compared with subjects who met TRS criteria and were not taking clozapine (p values < 0.05). TRS patients who took the longest time to start clozapine (third tertile) showed significantly higher CGI

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Salvat-Pujol

González-Rodríguez

Urretavizcaya

Moreno-Sancho L, Juncal-Ruiz M, Vázquez-Bourgon J, Ortiz-Garcia de la Foz V, Mayoral-van Son J, TordesillasGutierrez D, Setien-Suero E, Ayesa-Arriola R, Crespo-Facorro B. Naturalistic study on the use of clozapine in the early phases of non-affective psychosis: A 10-year follow-up study in the PAFIP-10 cohort.

Psychiatr Res. 2022 Sep;153:292-299. doi: 10.1016/j.jpsychires.2022.07.015. Epub 2022 Jul 6. PMID: 35878537.

Publicacions Científiques CSDM 2022

scores at 10-year follow-up compared to those who initiated clozapine earlier (first tertile) (t = 2.60; p = 0.043). Our findings reinforce the need of a timely assessment of treatment-resistant criteria in early schizophrenia patients and highlight the long-term benefits of an early introduction of clozapine on those patients meeting treatment-resistant criteria.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.250 Quartil: 2 Categoria: Psychiatry (SCIE) Posició: 54/155

Anti-NMDA receptor encephalitis in older adults: A systematic review of case reports. Gen Hosp Psychiatry. 2022 Jan-Feb;74:71-77. doi: 10.1016/j.genhosppsych.2021.11.006. PMID: 34929551.

Abstract

Clozapine is seldom prescribed in treatment-resistant schizophrenia (TRS) patients during early phases of the illness. We aimed to examine the pathway and patterns and the impact of clozapine use in patients with TRS who were followed up for 10 years after the first outbreak of the illness. Data were obtained retrospectively from an epidemiological cohort of first episode schizophrenia patients (n = 218) who had been treated in a specialized intervention program (PAFIP). Out of 218, 35 (16%) individuals were on clozapine at 10-year assessment, while 183 (84%) were taking other antipsychotics. Among those 183 psychosis subjects who were not on clozapine, 13 (7.1%) met criteria for TRS. In the clozapine group, ten (28.6%) met criteria for early-TR and twenty-five (71.4%) met criteria for late-TR. Before clozapine treatment was initiated, the median number of days under other antipsychotic treatment was 1551 days (IQR = 1715) and the median time that subjects remained on clozapine was 6.3 years (IC95%: 5.49-7.20). At 10 years, we found that those individuals taking clozapine had higher CGI total scores (F = 12.0, p = 0.001) and SANS total scores (F = 9.27, p = 0.003) than subjects taking other antipsychotics after correcting for baseline values. Interestingly, when performing these analyses at 10 years between subjects taking clozapine (n = 35) and subjects who despite meeting TRS criteria were not taking clozapine (n = 13), we found that subjects taking clozapine had significantly lower total scores on all clinical scales compared with subjects who met TRS criteria and were not taking clozapine (p values < 0.05). TRS patients who took the longest time to start clozapine (third tertile) showed significantly higher CGI scores at 10-year follow-up compared to those who initiated clozapine earlier (first tertile) (t = 2.60; p = 0.043). Our findings reinforce the need of a timely assessment of treatment-resistant criteria in early schizophrenia patients and highlight the long-term benefits of an early introduction of clozapine on those patients meeting treatment-resistant criteria.

Indexat a: MEDLINE/WOS/JCR

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Giné-Servén E, Serra-Mestres J, Martinez-Ramirez M, Boix-Quintana E, Davi- Loscos E, Guanyabens N, Casado V, Muriana D, Torres-Rivas C, Cuevas-Esteban J, Labad J.

Publicacions Científiques CSDM 2022

Background: The brain functional correlates of delusions have been relatively little studied. However, a virtual reality paradigm simulating travel on the London Underground has been found to evoke referential ideation in both healthy subjects and patients with schizophrenia, making brain activations in response to such experiences potentially identifiable.

Method: Ninety patients with schizophrenia/schizoaffective disorder and 28 healthy controls underwent functional magnetic resonance imaging while they viewed virtual reality versions of full and empty Barcelona Metro carriages.

Results: Compared to the empty condition, viewing the full carriage was associated with activations in the visual cortex, the cuneus and precuneus/posterior cingulate cortex, the inferior parietal cortex, the angular gyrus and parts of the middle and superior temporal cortex including the temporoparietal junction bilaterally. There were no significant differences in activation between groups. Nor were there activations associated with referentiality or presence of delusions generally in the patient group. However, patients with persecutory delusions showed a cluster of reduced activation compared to those without delusions in a region in the right temporal/occipital cortex.

Conclusions: Performance of the metro task is associated with a widespread pattern of activations, which does not distinguish schizophrenic patients and controls, or show an association with referentiality or delusions in general. However, the finding of a cluster of reduced activation close to the right temporoparietal junction in patients with persecutory delusions specifically is of potential interest, as this region is believed to play a role in social cognition.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 10.592 Quartil: 1 Decil: 1 Categoria: Psychiatry (SSCI) Posició: 11/143

Cirici Amell R, Soler AR, Cobo J, Soldevilla Alberti JM.

Psychological consequences and daily life adjustment for victims of intimate partner violence.

Int J Psychiatry Med. 2022 Jan 4:912174211050504. doi: 10.1177/00912174211050504. Epub ahead of print. PMID: 35393871.

Abstract

Introduction: Intimate partner violence (IPV) is a distressing reality worldwide. Victims of IPV usually experience long-term mental health disorders and maladjustments in their daily lives.

Aims: To examine the prevalence of depression, anxiety, and post-traumatic stress disorder in female victims of IPV that participated in a public mental health care program, and to analyze the relationships between the type of IPV exposure, its psychological consequences, and daily life adjustment.

Method: Up to 164 female victims of IPV referred by their primary care doctors to the Adult Mental Health Casntre of Sant Cugat del Vallès (Barcelona) between 2010 and 2016 were evaluated using several tests (Index of Spouse Abuse - ISA, Beck Depression Inventory - BDI-II, Sate-Trait Anxiety Inventory - STAI, the Maladjustement Scale - MS, and the Severity Symptom Scale for Post-traumatic Stress Disorder - EGS).

Results: Of the 164 referred women, 102 (62.2%) agreed to participate (mean age 44.98 years, range 19-71) and 73% scored above the cut-off point in the physical IPV dimension (ISA). Moreover, 73% had depression symptoms, 77% trait anxiety, and 87% state anxiety altered scores. Prevalence of post-traumatic stress disorder was also high (87%). IPV interfered significantly in all the aspects of the daily lives of 92% of the sample.

Conclusions: The participants of the study experienced many psychological symptoms and a high level of interference with all aspects of their daily lives. These consequences were of similar magnitude amongst victims of emotional abuse compared to those who suffered physical violence

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 1.275 Quartil: 4 Categoria: Psychiatry (SCIE) Posició: 142/155

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

J Psychiatr Res. 2022 May;149:217-225. doi: 10.1016/j.jpsychires.2022.02.041. Epub 2022 Mar 2. PMID: 35287052

Abstract

Our study aimed to explore whether stress-related hormones (hypothalamic-pituitary-adrenal [HPA] axis hormones and prolactin) are associated with poorer cognitive functioning in adolescents with attention deficit and hyperactivity disorder (ADHD) and to test the potential moderating effect of childhood maltreatment. Seventy-six adolescents with ADHD were studied. The ADHD rating scale (ADHD-RS) and Childhood Trauma Questionnaire (CTQ) were administered. Seven cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were administered, and two cognitive factors (attention and memory as well as executive functioning) were identified by confirmatory factor analysis. Stress-related hormone levels were assessed at the clinic (plasma prolactin and cortisol levels and salivary cortisol levels) before cognitive testing and at home for two consecutive days (cortisol awakening response [CAR] and diurnal cortisol slope). Multiple linear regression analyses were used to explore the association between hormone levels and ADHD severity or cognitive functioning while adjusting for sex and childhood maltreatment. Regarding hormonal measurements obtained at the clinic, female sex moderated the relationship between salivary cortisol levels and executive functioning, whereas childhood maltreatment moderated the relationship between salivary cortisol levels and inattention symptoms of patients with ADHD. Prolactin levels were not associated with cognitive functioning or the severity of ADHD. Regarding HPA axis measurements performed at home, lower cortisol levels at awakening were associated with poorer executive functioning. Neither CAR nor the cortisol diurnal slope were associated with cognitive functioning or ADHD severity. Our study suggests that HPA axis hormone levels are associated with the severity of cognitive and inattention symptoms of patients with ADHD and that childhood maltreatment and sex exert distinct moderating effects depending on the symptom type

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.250 Quartil: 2 Categoria: Psychiatry (SCIE) Posició: 54/155

Clocks Sleep. 2022 Feb 15;4(1):52-65. doi: 10.3390/clockssleep4010007. PMID: 35225953; PMCID: PMC8883931

Abstract

While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in these populations. Although melatonin treatment improved the quality and efficiency of the sleep of patients with schizophrenia, few studies have explored its use in postmenopausal women with schizophrenia. The estrogen and progesterone pathways are dysregulated in major psychiatric disorders, such as in schizophrenia. While, in the context of menopause, a high testosterone-to-estradiol ratio is associated with higher frequencies of depressive symptoms, the effects of estradiol and other sex hormones on sleep disorders in postmenopausal women with schizophrenia has not been sufficiently investigated. Raloxifene, a selective estrogen receptor modulator, has shown positive effects on sleep disorders in postmenopausal women. Future studies should

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Llorens M, Barba M, Torralbas J, Nadal R, Armario A, Gagliano H, Betriu M, Urraca L, Pujol S, Montalvo I, Gracia R, Giménez-Palop O, Palao D, Pàmias M, Labad J.

Stress-related biomarkers and cognitive functioning in adolescents with ADHD: Effect of childhood maltreatment.

González-Rodríguez A, Haba-Rubio J, Usall J, Natividad M, Soria V, Labad J, Monreal JA. Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review.

Publicacions Científiques CSDM 2022

investigate the effectiveness of hormonal compounds on insomnia in postmenopausal women with schizophrenia.

Indexat a: PubMed/WOS

Attempted suicide with intravenous methamphetamine and chemsex. Rev Colomb Psiquiatr (Engl Ed). 2022 Jan-Mar;51(1):76-80. English, Spanish. doi: 10.1016/j.rcpeng.2020.09.002. Epub 2022 Feb 21. PMID: 35210209.

Abstract

Background: Undiagnosed attention deficit and hyperactivity disorder (ADHD) is frequent in the substance abuse disorder population, and has an intense repercussion in the daily life of the patients. That condition increases the risk of substance abuse disorders and risk conducts derived from impulsivity. There are not yet studies linking ADHD and the new emergent phenomenon of chemsex, that is, the action of use the intravenous injection of substances in sex parties, with the objective of maximising the practising time and sexual experience. In these sessions, different types of drug are used, for example, synthetic cathinone or mephedrone, and may lead to diverse medical and psychiatric complications like psychosis, aggressiveness and suicide ideation.

Case: We report the case of a 44-year-old man admitted into a psychiatric unit, presenting with 2nd time suicidal high risk attempt using intravenous methamphetamine and a dissolvent acid in the context of a depressive episode, after practising chemsex sessions almost every weekend with psychoactive substances taken orally, intravenously and intrarectally. The patient also presented psychotic symptoms from the use of these drugs. When we interviewed the patient during his hospital stay, we observed that there were symptoms of a possible attention and hyperactivity deficit, which was confirmed by study with ASRS-V1.1 and WURS scales. After three weeks, the patient improved substantially as his depressive symptoms and autolytic ideation disappeared.

Discussion: Look for "hidden" symptoms in substance abuse disorder patients. It is important not to delay important diagnostic tests and to prevent complications. Psychiatric and medical conditions related to chemsex have been reported in several European cities, and recently in Spain where it is an emergent phenomenon and a problem concerning medical and political institutions. The suicide attempt with metamphetamine and acid taken intravenously in the case we report, depressive and psychotic symptoms, addiction, suicide attempts and medical complications are described.

Indexat a: MEDLINE

Abstract

Jumping to conclusions (JTC) and impaired social cognition (SC) affect the decoding, processing, and use of social information by people with psychosis. However, the relationship between them had not been deeply explored

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Garcia-Fuentes D, Fernández-Fernández EP, Planet Nielsen N, Batlle De Santiago E, Giné-Servén E, Cañete Crespillo J.

Publicacions Científiques CSDM 2022

within psychosis in general, and in first-episode psychosis (FEP) in particular. Our aim was to study the relationship between JTC and SC in a sample with FEP. We conducted a cross-sectional study with 121 patients with FEP, with measures to assess JTC (easy, hard, and salient probability tasks) and SC (emotional recognition, attributional style, and theory of mind). We performed Student's t-test and logistic regression in order to analyse these associations.We found a statistically significant and consistent relationship of small-moderate effect size between JTC (all three tasks) and impaired emotional recognition. Also, our results suggest a relationship between JTC and internal attributions for negative events. Relationships between JTC and theory of mind were not found. These results highlight the importance of psychological treatments oriented to work on a hasty reasoning style and on improving processing of social information linked to emotional recognition and single-cause attributions

Indexat a: PubMed/WOS

Sci

Abstract

2022 Jul 6;12(1):11386.

Metabolic syndrome (MetS) is a cluster of parameters encompassing the most dangerous heart attack risk factors, associated with increased morbidity and mortality. It is highly prevalent in recent-onset psychosis (ROP) patients. In this pilot study, we evaluated MetS parameters (fasting glucose, high-density lipoprotein (HDL) cholesterol (HDL-c), fasting triglycerides, waist circumference, and systolic and diastolic blood pressure), clinical symptoms, pharmacological treatment, lifestyle, and inflammatory markers in 69 patients with ROP and 61 healthy controls (HCs). At baseline, waist circumference (p = 0.005) and fasting triglycerides (p = 0.007) were higher in patients with ROP than in HCs. At the 1-year follow-up, patients showed clinical improvement, with a reduction in the positive and negative syndrome scale (PANSS) score (p < 0.001), dietary intake (p = 0.001), and antipsychotic medication dose (p < 0.001); however, fasting glucose (p = 0.011), HDL-c (p = 0.013) and waist circumference worsened (p < 0.001). We identified sex, age, BMI, dietary intake, physical activity, daily tobacco use, daily cannabis use, and antipsychotic doses as risk factors contributing to baseline MetS parameters. After 1-year follow-up, those factors plus the PANSS and Calgary Depression Scale for Schizophrenia (CDSS) scores were associated with MetS parameters. Further studies are needed to understand the contributions of the studied risk factors in patients with ROP at onset and during disease progression.

Abstract

Perceived personal wellbeing tends to be lower in individuals with autism spectrum disorders (ASD), especially in the case of women. To develop the present study, the Personal Wellbeing Index (PWI-A) was administered to a Spanish-speaking sample of women with ASD (N = 401) and self-diagnosed ASD (N = 343), women without ASD (N = 373) and men with ASD (N = 65) to compare their self-perceptions. Women with ASD showed significantly lower wellbeing rates than women in the control group for the total PWI-A and across all the domains, and

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08 67

Alonso Y, Miralles C, Algora MJ, Valiente-Pallejà A, Sánchez-Gistau V, Muntané G, Labad J, Vilella E, Martorell L. Risk factors for metabolic syndrome in individuals with recent-onset psychosis at disease onset and after 1year follow-up.

Rep.

doi: 10.1038/s41598-022-15479-x. PMID: 35794221; PMCID: PMC9259625.

Publicacions Científiques CSDM 2022

there were no significant differences when compared with self-diagnosed women with ASD and men with ASD. Autism explained between 24 and 26% of the decline in the PWI-A total score, with life achievement, future security, safety and relationships being the domains most highly correlated with the total. These findings are an effective contribution to improving diagnosis and professional intervention in women with ASD.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.345 Quartil: 2 Categoria: Psychology, Developmental (SSCI) Posició: 20/78

Fuentes-Claramonte P, Ramiro N, Torres L, Argila-Plaza I, Salgado-Pineda P, Soler-Vidal J, García-León MÁ, Albacete A, Bosque C, Panicalli F, Boix E, Munuera J, Tristany J, Sarró S, Bernardo M, Salvador R, McKenna PJ, Pomarol- Clotet E.

Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect.

Neuroimage Clin. 2022 Jul 16;35:103119. doi: 10.1016/j.nicl.2022.103119. Epub ahead of print. PMID: 35870381.

Abstract

Background: The negative symptoms of schizophrenia have been proposed to reflect prefrontal cortex dysfunction. However, this proposal has not been consistently supported in functional imaging studies, which have also used executive tasks that may not capture key aspects of negative symptoms such as lack of volition.

Method: Twenty-four DSM-5 schizophrenic patients with high negative symptoms (HNS), 25 with absent negative symptoms (ANS) and 30 healthy controls underwent fMRI during performance of the Computerized Multiple Elements Test (CMET), a task designed to measure poor organization of goal directed behaviour or 'goal neglect'. Negative symptoms were rated using the PANSS and the Clinical Assessment Interview for Negative Symptoms (CAINS).

Results: On whole brain analysis, the ANS patients showed no significant clusters of reduced activation compared to the healthy controls. In contrast, the HNS patients showed hypoactivation compared to the healthy controls in the left anterior frontal cortex, the right dorsolateral prefrontal cortex (DLPFC), the anterior insula bilaterally and the bilateral inferior parietal cortex. When compared to the ANS patients, the HNS patients showed reduced activation in the left anterior frontal cortex, the left DLPFC and the left inferior parietal cortex. After controlling for disorganization scores, differences remained in clusters in the left anterior frontal cortex and the bilateral inferior parietal cortex.

Conclusions: This study provides evidence that reduced prefrontal activation, perhaps especially in the left anterior frontal cortex, is a brain functional correlate of negative symptoms in schizophrenia. The simultaneous finding of reduced inferior parietal cortex activation was unexpected, but could reflect this region's involvement in cognitive control, particularly the 'regulative' component of this

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.891 Quartil: 2 Categoria: Neuroimaging Posició: 5/14

Prog Neuropsychopharmacol Biol Psychiatry. 2022 Aug 19;120:110619. doi: 10.1016/j.pnpbp.2022.110619. Epub ahead of print. PMID: 35988848

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Tost M, González-Rodríguez A, Aguayo R, Álvarez A, Montalvo I, Barbero JD, Gabernet R, Izquierdo E, Merodio I, Monreal JA, Palao D, Labad J

Switching from risperidone to paliperidone palmitate in schizophrenia: Changes in social functioning and cognitive performance.

Publicacions Científiques CSDM 2022

Abstract

Background: Previous studies suggest that paliperidone might show a better profile for social functioning and cognitive abilities than risperidone. We aimed to study whether switching from risperidone to paliperidone palmitate (PP) is associated with improved cognitive abilities at 3 or 6 months after the switch.

Methods: Thirty-eight patients with a DSM-IV diagnosis of schizophrenia were studied. All patients were treated with oral risperidone or risperidone long-acting injection (RLAI) and had an indication to be switched to PP by their psychiatrists. Statistical analyses were conducted in a final sample of 27 patients who completed the follow-up visits. Three assessments were completed: 1) baseline (preswitch), 2) 3 months postswitch, and 3) 6 months postswitch. Social functioning at each visit was assessed with the Personal and Social Performance Scale. Cognitive assessment was conducted at each visit with the MATRICS Consensus Cognitive Battery. Statistical analyses were performed with R. Linear mixed models were used to explore longitudinal changes in social functioning and cognitive outcomes.

Results: PSP scores significantly improved over time after the switch from risperidone to PP. A sensitivity analysis found a significant negative interaction between time and PP maintenance doses (greater improvement in those patients receiving lower doses when compared to higher doses). Regarding longitudinal changes in cognitive functioning, patients improved in 6 out of 10 cognitive tasks involving processing speed, working memory, visual memory, reasoning and problem solving, and attention and vigilance.

Conclusions: Our study suggests that switching from risperidone to PP in patients with schizophrenia is associated with an improvement in social functioning and cognitive performance.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.201 Quartil: 2 Categoria: Clinical Neurology Posició: 55/212

Vázquez-Bourgon J, Gómez-Revuelta M, Mayoral-van Son J, Labad J, Ortiz-García de la Foz V, Setién-Suero E, Ayesa-Arriola R, Tordesillas-Gutiérrez D, Juncal- Ruiz M, Crespo-Facorro B.

Pattern of long-term weight and metabolic changes after a first episode of psychosis: Results from a 10-year prospective follow-up of the PAFIP program for early intervention in psychosis cohort. Eur Psychiatry. 2022 Aug 16;65(1):e48. doi: 10.1192/j.eurpsy.2022.2308. PMID: 35971658.

Abstract

Background: People with psychosis are at higher risk of cardiovascular events, partly explained by a higher predisposition to gain weight. This has been observed in studies on individuals with a first-episode psychosis (FEP) at short and long term (mainly up to 1 year) and transversally at longer term in people with chronic schizophrenia. However, there is scarcity of data regarding longer-term (above 3-year follow-up) weight progression in FEP from longitudinal studies. The aim of this study is to evaluate the longer-term (10 years) progression of weight changes and related metabolic disturbances in people with FEP.

Methods: Two hundred and nine people with FEP and 57 healthy participants (controls) were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric, clinical, and sociodemographic data were collected.

Results: People with FEP presented a significant and rapid increase in mean body weight during the first year of treatment, followed by less pronounced but sustained weight gain over the study period (Δ15.2 kg; SD 12.3 kg). This early increment in weight predicted longer-term changes, which were significantly greater than in healthy controls (Δ2.9 kg; SD 7.3 kg). Weight gain correlated with alterations in lipid and glycemic variables, leading to clinical repercussion such as increments in the rates of obesity and metabolic disturbances. Sex differences were observed, with women presenting higher increments in body mass index than men.

Conclusions: This study confirms that the first year after initiating antipsychotic treatment is the critical one for weight gain in psychosis. Besides, it provides evidence that weight gain keep progressing even in the longer term (10 years), causing relevant metabolic disturbances.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 7.156 Quartil: 1 Categoria: Psychiatry (SCIE) Posició: 35/155

Smoking

Adicciones. 2022 Jul 1;34(3):227-234. English, Spanish. doi: 10.20882/adicciones.1492. PMID: 33768256.

Abstract

Substance use disorders (SUD) treatment centers are an optimal setting for delivering smoking cessation interventions (SCI). This study aimed to examine the adoption of SCI in SUD treatment centers in Catalonia (Spain) as well as to assess their managers' views on the appropriateness and feasibility of providing SCI. Managers directly in charge of SUD treatment centers (n = 57) answered a 30-item on-line questionnaire. Data was obtained of 50 centers (87.7% response rate). Forty-six per cent of the centers provided some kind of SCI, but only 4.8% of the new patients were treated for smoking cessation. Managers reported that 73.3% of mental health professionals working in SUD centers had not been trained in SCI. Sixty-four per cent of managers agreed that all health professionals should deliver SCI. Those centers offering SCI attended more patients and were more likely to have professionals trained in SCI than those not offering SCI. The implementation of SCI in SUD treatment centers in Catalonia was suboptimal. Continuing education and training should be provided for all health professionals working in SUD centers. Not systematically delivering SCI to patients in treatment for other SUD means missing opportunities to reduce health and economic costs while perpetuating a smoking culture.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.102 Quartil: 2 Categoria: Substance Abuse (SCIE) Posició: 10/21

Hidalgo

J Autism Dev Disord. 2021 Dec 25. doi: 10.1007/s10803-021-05400-2. Epub ahead of print. PMID: 34953140

Abstract

Perceived personal wellbeing tends to be lower in individuals with autism spectrum disorders (ASD), especially in the case of women. To develop the present study, the Personal Wellbeing Index (PWI-A) was administered to a Spanish-speaking sample of women with ASD (N = 401) and self-diagnosed ASD (N = 343), women without ASD (N = 373) and men with ASD (N = 65) to compare their self-perceptions. Women with ASD showed significantly lower wellbeing rates than women in the control group for the total PWI-A and across all the domains, and there were no significant differences when compared with self-diagnosed women with ASD and men with ASD. Autism explained between 24 and 26% of the decline in the PWI-A total score, with life achievement, future security, safety and relationships being the domains most highly correlated with the total. These findings are an effective contribution to improving diagnosis and professional intervention in women with ASD

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.345 Quartil: 2 Categoria: Psychology, Developmental (SSCI) Posició: 20/78

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Nieva G, Ballbè M, Cano M, Carcolé B, Fernández T, Martínez À, Mondon S, Raich A, Roig P, Serra I, Serrano J, Pinet C.

cessation interventions in substance use disorders treatment centers of Catalonia: The abandoned addiction.

PM, Martínez MM, González AG, Petisco LG, Forcadell CA, D'Agostino CI, de la Varga LP. Self-Perceived Quality of Life in Spanish-Speaking Women with Autism Spectrum Disorders.

Publicacions Científiques CSDM 2022

Álvarez A, Guàrdia A, González-Rodríguez A, Betriu M, Palao D, Monreal JA, Soria V, Labad J.

A systematic review and meta-analysis of suicidality in psychotic disorders: stratified analyses by psychotic subtypes, clinical setting and geographical region.

Neurosci Biobehav Rev. 2022 Nov 17:104964. doi: 10.1016/j.neubiorev.2022.104964. Epub ahead of print. PMID: 36403792

Abstract

We studied the prevalence of suicide attempts and cumulative incidence of completed suicide in schizophrenia (SZ), schizoaffective disorder (SZAF), delusional disorder (DD) and first-episode psychosis (FEP). A systematic review was performed using Scopus and PubMed databases (1990- July 2020). A random effects meta-analysis was conducted. Stratified analyses were conducted by diagnosis, clinical setting and geographical region. The prevalence of attempted suicide was 20.3% for SZ, 46.8% for SZAF, 11.1% for DD and 12.5% for FEP. Suicide attempts rates were higher for outpatient samples than for inpatient samples in SZ, SZAF and DD (but not FEP) studies. Analyses by geographical region in SZ showed greater prevalence of suicide attempts in North America and Northern Europe. The cumulative incidence of completed suicide was 2.0% for SZ, 2.4% for SZAF; 2.2% for DD and 1.9% for FEP. In schizophrenia and FEP studies, Northern European studies reported higher rates of completed suicide when compared to Western European countries. In conclusion, suicidal behaviour rates in psychoses differ by diagnoses, clinical setting and geographical region.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 9.052 Quartil: 1 Decil: 1 Categoria: Behavioral Sciences Posició: 3/53

Cognitive and clinical gender-related differences among binge-spectrum eating disorders: Analysis of therapy response predictors.

Eur Eat Disord Rev. 2022 Dec 8. doi: 10.1002/erv.2961. Epub ahead of print. PMID: 36482806.

Abstract

Objective: This study assessed gender-related differences in executive functions (decision-making, inhibitory control and cognitive flexibility), personality traits and psychopathological symptoms in binge-spectrum eating disorders (EDs). Secondly, we aimed to separately explore the predictive value of gender and executive functions in treatment outcome.

Method: A battery of self-reported and neurocognitive measures were answered by a sample of 85 patients (64 females) diagnosed with a binge-spectrum ED (41 BN; 44 binge eating disorder).

Results: Data showed gender-related differences in executive functioning, displaying women lower inhibitory control and lower cognitive flexibility than men. Regarding personality traits and psychopathology symptoms, women presented higher reward dependence and cooperativeness, as well as more drive for thinness, body dissatisfaction, bulimia, and somatisation symptoms than men. Finally, worse executive functioning, particularly having lower ability in concept formation seems to predict worse treatment outcomes and dropout in these patients.

Conclusions: We described gender specific neuropsychological, personality and psychopathological impairments in patients with binge-spectrum EDs. Moreover, difficulties in executive functioning might have an impact on treatment response, since patients with a lower ability in concept formation are less likely to benefit from

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Mallorquí-Bagué N, Lozano-Madrid M, Granero R, Mestre-Bach G, Vintró-Alcaraz C, Sánchez I, Jiménez-Murcia S, Fernández-Aranda F.

Publicacions Científiques CSDM 2022

treatment. The present results can help improving current treatment approaches by tackling gender and individual differences.

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 5.360 Quartil: 1 Categoria: Psychology, Clinical Posició: 25/131

Solanes A, Mezquida G, Janssen J, Amoretti S, Lobo A, González-Pinto A, Arango C, Vieta E, Castro-Fornieles J, Bergé D, Albacete A, Giné E, Parellada M, Bernardo M; PEPs group (collaborators), Pomarol-Clotet E, Radua J. Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis. Schizophrenia (Heidelb). 2022 Nov 17;8(1):100. doi: 10.1038/s41537-022-00309-w. PMID: 36396933.

Abstract

Detecting patients at high relapse risk after the first episode of psychosis (HRR-FEP) could help the clinician adjust the preventive treatment. To develop a tool to detect patients at HRR using their baseline clinical and structural MRI, we followed 227 patients with FEP for 18-24 months and applied MRIPredict. We previously optimized the MRI-based machine-learning parameters (combining unmodulated and modulated gray and white matter and using voxel-based ensemble) in two independent datasets. Patients estimated to be at HRR-FEP showed a substantially increased risk of relapse (hazard ratio = 4.58, P < 0.05). Accuracy was poorer when we only used clinical or MRI data. We thus show the potential of combining clinical and MRI data to detect which individuals are more likely to relapse, who may benefit from increased frequency of visits, and which are unlikely, who may be currently receiving unnecessary prophylactic treatments. We also provide an updated version of the MRIPredict software

Indexat a: PubMed/WOS

Incidence rate and distinctive characteristics of first episode psychosis during the COVID-19 pandemic: a multicenter observational study.

Sci Rep. 2022 Dec 21;12(1):22036. doi: 10.1038/s41598-022-26297-6. PMID: 36543820

Abstract

The COVID-19 pandemic has affected the mental health of people around the world. However, its impact on first-episode psychosis (FEP) remains unclear. The aim of this study was to determine the incidence rate (IR) and the clinical and sociodemographic characteristics of patients who developed FEP during the nine-month period following the COVID-19 outbreak in Spain and to compare these data to the corresponding period in the previous year. We included all patients (n = 220) treated for the first time during these two time periods at three FEP programs in Spain. The IR was 0.42/100,000 person-years during the pandemic vs. 0.54/100,000 in the prior year (p = 0.057). Compared to prior year, women accounted for a significantly higher proportion of FEP patients (46.3% vs. 28%; p = 0.005) during the COVID-19 period. This association was significant on the logistic regression analysis (odds ratio, female: 2.12 [confidence interval 1.17-3.82]; p = 0.014). These data reveal a non-significant trend towards a lower incidence of FEP during the pandemic period. Female sex was associated with a greater risk of developing FEP during the pandemic period, perhaps due to differences between males and females in the susceptibility and expression of psychosis. The findings of this study contribute to a better understanding of stress-related disorders

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Casanovas F, Trabsa A, Bergé D, Sánchez-Gistau V, Moreno I, Sanchez J, Montalvo I, Tost M, Labad J, Pérez-Solà V, Mané A.

Publicacions Científiques CSDM 2022

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 4.997 Quartil: 2 Categoria: Multidisciplinary Sciences Posició: 19/74

Women. 2022; 2(1):1-14. https://doi.org/10.3390/women2010001

Abstract

Sex and age are important factors influencing physical and mental health in schizophrenia. Our goal was to review the recent literature for associations between gynecological conditions and psychotic illness and to propose integrated strategies for their management in order to improve overall health outcomes in women. We addressed the following questions: What are the prevalence and risk factors of gynecological disorders in women with schizophrenia or delusional disorder (DD)? What are the rates of uptake of gynecological cancer screening and mortality in this population? What role does menopause play? We found an increased incidence of breast cancer in women with schizophrenia. Other gynecological comorbidities were less frequent, but the field has been understudied. Low rates of breast and cervical cancer screening characterize women with schizophrenia. Menopause, because of endocrine changes, aging effects, and resultant comorbidity is associated with high rates of aggressive breast cancer in this population. Uterine and ovarian cancers have been less investigated. Psychosocial determinants of health play an important role in cancer survival. The findings lead to the recommendation that primary care, psychiatry, gynecology, oncology, and endocrinology collaborate in early case finding, in research into etiological links, and in improvement of prevention and treatment

UNITAT DE RECERCA

RESEARCH UNIT

Abstract

Background: primary care screening for frailty status is recommended in clinical guidelines, but is impeded by doctor and nurse workloads and the lack of valid, easy-to-use and time-saving screening tools.

Aim: to develop and validate a new electronic tool (the electronic screening index of frailty, e-SIF) using routinely available electronic health data to automatically and massively identify frailty status in the population aged ≥65 years.

Methods: the e-SIF was developed in three steps: selection of clinical conditions; establishment of ICD-10 codes, criteria and algorithms for their definition; and electronic tool design and data extraction, transformation and load processes. The validation phase included an observational cohort study with retrospective data collection from computerised primary care medical records. The study population included inhabitants aged ≥65 years corresponding to three primary care centres (n = 9,315). Evaluated was the relationship between baseline e-SIF categories and mortality, institutionalisation, hospitalisation and health resource consumption after 2 years.

Results: according to the e-SIF, which includes 42 clinical conditions, frailty prevalence increases with age and is slightly greater in women. The 2-year adjusted hazard ratios for pre-frail, frail and very frail subjects, respectively, were as follows: 2.23 (95% CI: 1.74-2.85), 3.34 (2.44-4.56) and 6.49 (4.30-9.78) for mortality; 2.80

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

González-Rodríguez A, Seeman MV, Guàrdia A, Natividad M, Marín M, Labad J, Monreal JA. Gynecological Health Concerns in Women with Schizophrenia and Related Disorders: A Narrative Review of Recent Studies.

À, Cabré M, Burdoy E, Palomera E, Papiol M, Parera JM

Publicacions Científiques CSDM 2022

(2.39-3.27), 5.53 (4.59-6.65) and 9.14 (7.06-11.8) for hospitalisation; and 1.02 (0.70-1.49), 1.93 (1.21-3.08) and 2.69 (1.34-5.40) for institutionalisation.

Conclusions: the e-SIF shows good agreement with mortality, institutionalisation, hospitalisation and health resource consumption, indicating satisfactory validity. More studies in larger populations are needed to corroborate our findings.

Indexat a: WOS/JCR

Factor Impacte: 12.782 Quartil: 1 Decil:1 Categoria: Geriatrics & Gerontology Posició: 1/54

J Frailty Aging. 2022;11(1):91-99. doi: 10.14283/jfa.2021.38. PMID: 35122096.

Abstract

Background: Obesity is a risk factor for frailty and muscle weakness, so weight loss in obese older adults may prevent frailty and functional decline.

Objective: To assess the safety and efficacy of a multimodal weight-loss intervention in improving functional performance and reducing frailty risk in obese older adults.

Design: Randomized controlled trial with 2 parallel arms.

Setting and participants: Community-dwelling obese adults aged 65-75 years with body mass index (BMI) 30-39 kg/m2.

Intervention: 6-month multimodal intervention based on diet and a physical activity program.

Control group: Usual care. Main and secondary outcome measures: Frailty (Fried criteria) rate and functional performance at 6, 12, and 24 months of follow-up, respectively. Intermediate outcome measures: Weight loss, body composition changes, and metabolic and inflammatory biomarker changes.

Results: N=305. The study intervention increased gait speed at 12 and 24 months of follow-up, but had no significant effect on frailty prevention. It was effective in reducing weight, BMI, fat mass, interleukin 6, and insulin resistance and improving self-reported quality of life.

Conclusions: The study intervention was not demonstrated to be effective in preventing frailty in obese people aged 65-75 years at 24 months of follow-up. However, it allowed weight loss and a reduction in inflammatory and insulin resistance markers, which could have a long-term effect on frailty that requires further research.

Indexat a: MEDLINE/WOS

Relationship with Plasmaosmolarityinaged Population.

J Fam Med. 2022; 9(5): 1305.

Abstract

Background: The causes of age-related poor urine concentration capacity favouring low-grade chronic dehydration in aged populations are not well understood.

Objectives: To explore links between age and plasma and urine osmolarity levels and a possible picture of peripheral resistance to arginine vasopressin (R-AVP) in an aged population.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Serra-Prat M, Terradellas M, Lorenzo I, Arús M, Burdoy E, Salietti A, Ramírez S, Palomera E, Papiol MS, Pleguezuelos E.

Effectiveness of a Weight-Loss Intervention in Preventing Frailty and Functional Decline in CommunityDwelling Obese Older People. A Randomized Controlled Trial.

Serra-Prat M, Lorenzo I, Pérez-Cordon L, Campins L, Palomera E, Ruiz A, Cabré M, Pleguezuelos E. Peripheral Resistance to Arginine Vasopressin and Its

Publicacions Científiques CSDM 2022

Design: observational cross-sectional study. Study population: communitydwelling subjects aged 70 years and older. Data collection: Blood and urine samples collected after 10 hours night fasting were analysed for osmolarity and copeptin levels (AVP surrogate). R-AVP was established based on a urinary osmolarity/copeptin ratrio<35.

Results: 237 subjects were recruited (mean age 75.7 years, 52.7% women). Plasma osmolarity was similar between the sexes and age groups (70-79 and ≥80 years); whereas urine osmolarity was lower in women and in the older age group. Plasma hyperosmolarity (>295 mOsm/L) was present in no women and in 4.5% of men, and was significantly 14 times greater in the older group. R-AVP prevalence was 12.7% in the younger group vs 20.7% in the older group (p=0.252). Subjects with R-AVP, compared to without R-AVP, presented higher plasma osmolarity (287.6 vs 285.4 mOsm/L; p=0.023) and higher prevalence of plasma hyperosmolarity (8.7% and 0.7%; p=0.053). R-AVP was also related with IL-6 and creatinine levels and with loop diuretic use.

Conclusions: Urine concentration capacity decreases and plasma hyperosmolarity increases after the age of 80 years. Fourteen percent of ≥70 year’s old population present R-AVP, which greatly increases the risk of plasmahyperosmolarity and is related with loop diuretic use, and IL-6 and creatinine levels

UROLOGIA– UROLOGY

Nº Articles indexats: 2 Factor Impacte total: 1.317 Factor d’impacte liderat: 0

A

Arch Esp Urol. 2022 Nov;75(9):753-757. doi: 10.56434/j.arch.esp.urol.20227509.110. PMID: 36472057

Abstract

Background: The objective of this article was to assess the long-term efficacy and safety of the MV140 vaccine to prevent recurrent urinary tract infections (UTIs).

Methods: This is a prospective, descriptive, comparative and multicenter study of 1003 patients with 3 or more urinary infections for 12 months, treated with the MV140 vaccine from 2011 to 2021.

Variables: Age, gender, urinary infections at 3, 6 and 12 months, distribution according to age and months of the year, smoking, use of MV140 vaccines and autovaccines.

Results: Mean age was 78 and 82.7% were women. At baseline, 84.1% had 3 to 5 infections. According to age, 68.6% had >70 years. There were more consultations in March (12.3%) and fewer in August (4.4%). Smokers represented 24.6% and 21.8% follow autovaccines. Results at 3 months: 0 UTI 45%, 1 UTI 31.3%, 2 UTI 19.2%. 6 months: 0 UTI 29.3%, 1 UTI 33.2%, 2 UTI 24.3%. 12 months: 0 UTI 9%, 1 UTI 28.2%, 2 UTI 17.5%. Smokers: 0-1 UTI 80.2% (3 months), 65.5% (6 months), 53.9% (12 months). Non-smokers: 0-1 UTI 85.8% (3 months), 66.8% (6 months), 20% (12 months). p = 0.41, 0.27 and 0.21 respectively. Vaccines: 0-1 UTI 74.5% (3 months), 61% (6 months), 38.8% (12 months). Autovaccines: 0-1 UTI 82.7% (3 months), 68 % (6 months), 28.2% (12 months). p = 0.04, 0.25 and 0.63 respectively.

Conclusions: MV140 reduced the number of UTI to 0-2 in 95.5% at 3 months, 86.8% at 6 months and 54.7% at 12 months. Smoking did not worsen the response of MV140. Autovaccines achieved better results than vaccines only at 3 months. Adverse effects represented 1.49%, but no patient had to abandon treatment

Indexat a: MEDLINE/WOS/JCR

Factor Impacte: 0.430 Quartil: 4 Categoria: Urology & Nephrology Posició: 89/90

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Ramírez Sevilla C, Gómez Lanza E, Llopis Manzanera J, Cetina Herrando A, Puyol Pallàs JM.

Focus on Long-Term Follow-Up of Immunoprophylaxis to Recurrent Urinary Tract Infections: 10 Years of Experience with MV140 Vaccine in a Cohort of 1003 Patients Support High Efficacy and Safety.

Publicacions Científiques CSDM 2022

Ramírez-Sevilla C,

A, Puyol-Pallàs JM. Effectiveness and health cost analysis between immunoprophylaxis with MV140 autovaccine, MV140 vaccine and continuous treatment with antibiotics to prevent recurrent urinary tract infections. Actas Urol Esp (Engl Ed). 2022 Aug 12:S2173-5786(22)00091-9. English, Spanish. doi: 10.1016/j.acuroe.2022.08.016. Epub ahead of print. PMID: 36470711.

Abstract

Introduction: The objective of this study was to compare the results on prevention of uncomplicated recurrent UTI between continuous use of antibiotics, MV140 autovaccine and MV140 polybacterial vaccine from collection strain.

Methods: 377 patients were prospectively analyzed from January 2017 to August 2019 and divided into 3 groups according to the prophylaxis. Group A (126): antibiotics, Group B (126): MV140 autovaccine, Group C (125): MV140 polybacterial vaccine from the collection strain. Variables analyzed were: gender, age, menopause, number of UTI at baseline and 3 and 6 months after the end of prophylaxis, health cost along follow-up at 3 and 6 months.

Results: At 3 months, group A had 0-1 UTI in 65%, group B had 0-1 UTI in 80.8% and group C in 81.7%. At 6 months, group A had 0-1 UTI in 44.4%, group B had 0-1 UTI in 61.6% and group C in 74.6%. Regarding health cost along follow-up, at 3 months group A had euro21,171.87, group B had euro20,763.73 and group C euro18,866.14. At 6 months, health cost was euro32,980.35 in group A, euro28,133.42 in group B, and euro23,629.19 in group C.

Conclusions: MV140 autovaccine and MV140 polybacterial vaccine were more efficient with lower number of UTI at 3 and 6 months and lower health cost along follow-up compared to continued prophylaxis with antibiotics (p < 0.05). Polybacterial MV140 vaccine from collection strain had higher effect to reduce the number of UTI and less health cost than autovaccine.. Indexat a: MEDLINE/WOS/JCR Factor Impacte: 0.887 Quartil: 4 Categoria: Urology & Nephrology Posició: 84/90

Sevilla C, Gómez Lanza E, Llopis Manzanera J, Romero Martin JA, Barranco Sanz MA Immunoprophylaxis in Recurrent Urinary Tract Infection. In: Dökmeci, F., Rizk, D.E.E. (eds) Insights Into Incontinence and the Pelvic Floor. (2022). Springer, Cham. https://doi.org/10.1007/978-3-030-94174-1_28.

Abstract:

This study analyzes the efficacy of Uromune® in reducing the episodes of UTI at 3, 6, and 12 months of follow-up in a cohort of 784 patients with uncomplicated recurrent UTI. The average age of the sample was 73, female represented 83% and 90% were menopausal. At the beginning 94.4% presented between 3 and 6 UTI. At 3 months 71% presented 0–1 UTI, at 6 months 64%, and at 12 months more than 60%.

Female presented better results than the male with 73%, 65%, and 61% of 0–1 UTI at 3, 6, and 12 months compared to 61%, 58%, and 57% in male.

Menopausal had better response at 3, 6, and 12 months with 0–1 UTI in 74%, 66%, and 62% compared to premenopausal with 64%, 56%, and 40%.

Uromune® obtained high effectiveness reducing UTI to 0–1 in 71.7%, 64.7%, and 60.7% at 3, 6, and 12 months, most in menopausal.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Gómez-Lanza E, Llopis-Manzanera J, Cetina-Herrando

Ramirez Sevilla C, Gómez Lanza E, Llopis Manzanera J, Romero Martin JA, Barranco Sanz MA Recurrent Urinary Tract Infection. (2022) In: Dökmeci, F., Rizk, D.E.E. (eds) Insights Into Incontinence and the Pelvic Floor. Springer, Cham. https://doi.org/10.1007/978-3-030-94174-1_27.

Publicacions Científiques CSDM 2022

Abstract:

The objective of this study has been to analyze the efficacy of the Uromune® autovaccine (Group B, 44 patients) in relation to Uromune® vaccine from the collection strain (Group C, 45) and the prophylaxis with antibiotics (Group A, 42) to reduce UTI episodes at 3 and 6 months of follow-up.

Uromune® provided greater efficacy than continued treatment with antibiotics obtained at 3 months 0–1 UTI in 86.4% with autovaccine and 86.7% with vaccine strain collection with respect to 66.5% with antibiotics.

At 6 months of follow-up, the results were 0–1 UTI in 72.8% with autovaccine and 71.1% with collection strain with respect to 50% with antibiotics.

The results were similar between autovaccine and collection strain at 3 months but higher with autovaccine at 6 months.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

ARTICLES INDEXATS* PER SERVEI

Psiquiatria 20 7 Motilitat Digestiva 12 8 Medicina Interna 12 3 Medicina Intensiva 10 1 Pediatria 9 8 Neurologia 8 1 Cirurgia General 7 3 Medicina Física i Rehabilitació 5 1 Digestiu 4 0 Farmacia 3 2 Neumologia 3 1 Oncologia 3 0 Cirurgia Ortopèdica i Traumatologia 2 2 Unitat de Recerca 2 2 Anestesiologia 2 0 Hematologia 2 0 Urologia 2 0 Direcció 1 1 Medicina de Família 1 1 Oftalmologia 1 1 Cirurgia Vascular 1 0 Dermatologia 1 0

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions

Científiques CSDM 2022

FACTOR D’IMPACTE*

FI Total per Servei* FI liderat CSDM**

Medicina Intensiva 140.735 2.799 Psiquiatria 88.805 37.700 Motilitat Digestiva 59.619 41.487 Neurologia 58.350 1.235 Medicina Interna 53.765 8.111 Cirurgia general 24.163 4.481 Medicina Física i Rehabilitació 23.223 4.997 Digestiu 22.700Oncologia 18.997Pediatria 14.376 11.999 Unitat de Recerca 12.782 12.782 Neumologia 12.666 6.333 Hematologia 7.425Farmàcia 6.498 5.329 Anestesiologia i Reanimació 5.721 -

Cirurgia Vascular 3.007Cirurgia Ortopèdica & Traumatol. 2.789 2.789 Oftalmologia 2.536 2.536 Dermatologia 2.481Medicina de Família 2.290 2.290 Urologia 1.317Alimentació i Dietètica 1.057 1.057

* Font: Journal Citation Reports, JCR: 2021 ** Articles amb primer, últim o corresponding autor CSDM.

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Publicacions Científiques CSDM 2022

RESUM INDICADORS BIBLIOMÈTRICS CSDM 2016-2022

Biblioteca. Direcció Acadèmica, Recerca i Innovació. Plantilla març-08

Plantilla març 08

Biblioteca Consorci Sanitari del Maresme. 2022