The Pharmacologist is published and distributed by the American Society for Pharmacology and Experimental Therapeutics.
Contents 4 Introduction 5 Oat Sprouts and the Topliss Tree: Rationalizing SAR
12 Stamping Out Drug Tampering 21
The Crohn Legacy: From Halitosis to Colitis and Beyond
THE PHARMACOLOGIST PRODUCTION TEAM Rich Dodenhoff Catherine Fry, PhD Judith A. Siuciak, PhD Suzie Thompson COUNCIL President Kenneth E. Thummel, PhD President-Elect David R. Sibley, PhD Past President Annette E. Fleckenstein, PhD Secretary/Treasurer Dennis C. Marshall, PhD Secretary/Treasurer-Elect Charles P. France, PhD Past Secretary/Treasurer Paul A. Insel, PhD Councilors Wayne Backes, PhD John D. Schuetz, PhD
30 The Great Dogsled Relay: The Race against Diphtheria
41 How Paul Janssen’s Drugs Saved the Chinese Terracotta Warriors
52 Blue Bloods: How the Humble Horseshoe Crab Helps Save Human Lives
61 Sleepy Sickness, Oliver Sacks, and the Early Days of L-Dopa
71 Sidney Farber, Methotrexate, and the Jimmy Fund: The Birth of Modern Chemotherapy
Margaret E. Gnegy, PhD Chair, Board of Publications Trustees Mary E. Vore, PhD Chair, Program Committee Scott Waldman, MD, PhD FASEB Board Representative Brian M. Cox, PhD Executive Officer Judith A. Siuciak, PhD The Pharmacologist (ISSN 0031-7004) is published quarterly in March, June, September, and December by the American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20814-3995. Copyright © 2016 by the American Society for Pharmacology and Experimental Therapeutics Inc. All rights reserved. If you would like a print subscription to The Pharmacologist, please contact the membership department at membership@aspet.org. ASPET assumes no responsibility for the statements and opinions advanced by contributors to The Pharmacologist.
The Pharmacologist • Special Edition