page_20_5-(Aminomethyl)-1,2-oxazol-3-one hydrate (Muscimol hydrate) [C4H8N2O3; C4H6N2O2·H2O]

5-(Aminomethyl)-1,2-oxazol-3-one hydrate (Muscimol hydrate) [C4H8N2O3]

Query Query

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Date

1 reactions in Reaxys

2018-08-03 20h:55m:46s (UTC)

H 2O HN O

1. Query

O NH 2

Search as: Product, As drawn, No mixtures ) AND (IDE.RN='305808-13-3') AND (IDE.INCHI='QYGRQAWQDLPUDKUHFFFAOYSA-N') NOT (RX.RXRN=14819161))

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2018-08-03 21:04:06

5-(Aminomethyl)-1,2-oxazol-3-one hydrate (Muscimol hydrate) [C4H8N2O3]

O O

N

HN

HN O O

HN

O

H 2O

N

NH 2 NH O

S

O

O

Rx-ID: 24338252 View in Reaxys 1/1 Yield 32%

Conditions & References 17 : 2-{2-Ethoxy-5-[(5-isoxazolin-3-onylmethyl)sulphamoyl]-phenyl}pyrido[3,2-d]pyrimidin-4(3H)-one EXAMPLE 17 2-{2-Ethoxy-5-[(5-isoxazolin-3-onylmethyl)sulphamoyl]-phenyl}pyrido[3,2-d]pyrimidin-4(3H)-one Obtained using muscimol hydrate in 32percent yield, m.p. indeterminate (amorphous solid).

Rf 0.40 (dichloromethane:methanol:glacial acetic acid, 90:10:1).

Patent; Cell Pathways, Inc.; US6060477; (2000); (A) English View in Reaxys

32%

17 : 2-{2-Ethoxy-5-[(5-isoxazolin-3-onylmethyl)sulphamoyl]-phenyl}pyrido [3,2-d]pyrimidin-4(3H)-one EXAMPLE 17 2-{2-Ethoxy-5-[(5-isoxazolin-3-onylmethyl)sulphamoyl]-phenyl}pyrido [3,2-d]pyrimidin-4(3H)-one Obtained using muscimol hydrate in 32percent yield, m.p. indeterminate (amorphous solid).

Rf 0.40 (dichloromethane: methanol: glacial acetic acid, 90:10:1). Found: C,51.01; H,3.86; N,15.49. C19 H17 N5 O6 S requires C,51.46; H,3.86; N,15.79percent.

Patent; Pfizer Inc.; US5591742; (1997); (A) English View in Reaxys

Copyright Š 2018 Elsevier Life Sciences IP Limited except certain content provided by third parties. Reaxys is a trademark of Elsevier Life Sciences IP Limited.

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2018-08-03 21:04:06