4-Methylbenzenesulfonohydrazide hydrochloride (TsNHNH2·HCl) [C7H11ClN2O2S; C7H10N2O2S·ClH]

4-Methylbenzenesulfonhydrazide hydrochloride [C7H10N2O2S·ClH]

Query Query Cl

Results

Date

4 reactions in Reaxys

2018-08-12 14h:23m:27s (UTC)

H

O

1. Query

O

H 2N

S NH

Search as: Product, As drawn, No mixtures ) AND (IDE.INCHI='WQLWGGFWTRRLKP-UHFFFAOYSA-N') NOT (RX.RXRN=3719947))

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2018-08-12 14:28:33

4-Methylbenzenesulfonhydrazide hydrochloride [C7H10N2O2S·ClH]

H 2N

O O

S

NH Cl

S

O

Cl

H

O

Rx-ID: 34024170 View in Reaxys 1/4 Yield

Conditions & References Reaction Steps: 2 1: hydrazinium sulfate; sodium hydroxide / water / 20 - 90 °C / pH 7.3 2: hydrogenchloride / water; diethyl ether; benzene With hydrogenchloride, sodium hydroxide, hydrazinium sulfate in diethyl ether, water, benzene Mamedov; Mamedova; Guseinov; Ladokhina; Fatalizade; Farzaliev; Petroleum Chemistry; vol. 52; nb. 4; (2012); p. 284 287 View in Reaxys O

O

H 2N

NH

S

H 2N

Cl

S

O

NH

H

O

Rx-ID: 34024179 View in Reaxys 2/4 Yield

Conditions & References With hydrogenchloride in diethyl ether, water, benzene Mamedov; Mamedova; Guseinov; Ladokhina; Fatalizade; Farzaliev; Petroleum Chemistry; vol. 52; nb. 4; (2012); p. 284 287 View in Reaxys H 2N

NH O

Cl

S

H

O

Rx-ID: 9721119 View in Reaxys 3/4 Yield 92.4%

Conditions & References 2.1.3 : [2-1-2] [2-1-3] Synthesis of N1 -9-(4-methoxy)acridinyl-N 2 -p-toluenesulfonylhydrazine hydrochloride (18) A mixed solution comprising 817 mg of 9-chloro-4-methoxyacridine (17), 749 mg of p-toluenesulfonylhydrazide and 20 ml of n-amyl alcohol was allowed to react at 70° C. for a period of one hour.

After the completion of the reaction, the reacted solution was cooled to room temperatures.

Then, the precipitated crystals were collected by filtering and washed with ethyl acetate.

Thereafter, 1.33 g of N1 -9-acridinyl-N2 -p-toluenesulfonylhydrazine hydrochloride (18) was obtained as crystals on drying (yield 92.4percent).

Without purification at this stage, the operation proceeded to the next reaction as it was.

Patent; Nippon Paper Industries Co., Ltd.; US5792863; (1998); (A) English View in Reaxys

O S

N N H

O

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2018-08-12 14:28:33

4-Methylbenzenesulfonhydrazide hydrochloride [C7H10N2O2S·ClH]

H 2N

O

NH O

Cl

S

O

H

S Cl

O

S N

N

Rx-ID: 2135853 View in Reaxys 4/4 Yield 89 %

Conditions & References With disulfur dichloride in dichloromethane, Time= 0.5h, T= 20 °C , other reagents (SOCl2, SCl2) and time, Product distribution Bellesia, Franco; Grandi, Romano; Pagnoni, Ugo M.; Trave, Roberto; Gazzetta Chimica Italiana; vol. 111; nb. 7/8; (1981); p. 289 - 292 View in Reaxys

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2018-08-12 14:28:33