1-(3-Methoxyphenyl)cyclohexan-1-amine hydrochloride (3-MeO-PCA·HCl)

1-(3-Methoxyphenyl)cyclohexan-1-amine hydrochloride (3-MeO-PCA·HCl)

Query Query Cl

1. Query O

Results

Date

1 reactions in Reaxys

2018-07-31 11h:02m:32s (UTC)

H

H 2N

Search as: Product, As drawn, No mixtures ) AND (IDE.RN='125802-06-4') AND (IDE.INCHI='NKLOFEKZVVGNHBUHFFFAOYSA-N') NOT (RX.RXRN=3634378))

Copyright © 2018 Elsevier Life Sciences IP Limited except certain content provided by third parties. Reaxys is a trademark of Elsevier Life Sciences IP Limited.

1/2

2018-07-31 11:03:50

1-(3-Methoxyphenyl)cyclohexan-1-amine hydrochloride (3-MeO-PCA·HCl)

O S

NH

Cl

O

H

H 2N

O

Rx-ID: 23512553 View in Reaxys 1/1 Yield

Conditions & References 55 :To a 50 mL round-bottom flask was added the tert-butyl sulfinimine (1. 16 g, 3. 75 mmol), MeOH (20ml) and HCI/dioxane (5 mL) and allowed to stir at room temperature for 30min. Disappearance of starting material was monitored by HPLC. The reaction was concentrated to give a solid which was dried, rinsed with Et20 (2x), and dried again in vacuo. MS (ESI) 189.0.

With hydrogenchloride in 1,4-dioxane, methanol, Time= 0.5h, T= 20 °C Patent; ELAN PHARMACEUTICALS, INC.; WO2005/70407; (2005); (A1) English View in Reaxys

Copyright © 2018 Elsevier Life Sciences IP Limited except certain content provided by third parties. Reaxys is a trademark of Elsevier Life Sciences IP Limited.

2/2

2018-07-31 11:03:50