N-Methyl-1-phenylpropan-2-amine (Methamphetamine)

Reaxys

PubChem

eMolecules

Reactions (368)

Substances (168)

Citations (3449)

Structure

Structure/Compound Data Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; D-mandelate

N° of preparations All Preps | All Reactions

Available Data

no reactions.

Physical Data (1)

1

no reactions.

Physical Data (1)

1

N° of ref.

Reaxys Registry Number: 6121829

CAS Registry Number: 85445-00-7 Type of Substance: isocyclic Molecular Formula: C8H8O3*C10H15N Linear Structure Formula: C10H15N*C8H8O3

Molecular Weight: 301.386

InChI Key: QMSAZBMWZVIYFU-IRAZKAIOSA-N

100

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; D-mandelate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; D-Mandelat Physical Data Melting Point (1) Melting Point

Reference

96 - 97 °C

Chiang; Li

Journal of the Chinese Chemical Society (Peking), 1951 , vol. 18, p. 161 Full Text Show Details

Chemical Name: methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; D-mandelate Reaxys Registry Number: 6121830

CAS Registry Number: 85444-98-0 Type of Substance: isocyclic Molecular Formula: C8H8O3*C10H15N Linear Structure Formula: C10H15N*C8H8O3

Molecular Weight: 301.386

InChI Key: QMSAZBMWZVIYFU-XPNWLKPYSA-N

101

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; D-mandelate, Methyl-((R)-1-methyl-2-phenyl-aethyl)-amin; D-Mandelat Physical Data Melting Point (1) Melting Point

Reference

96 - 97 °C

Chiang; Li

Journal of the Chinese Chemical Society (Peking), 1951 , vol. 18, p. 161 Full Text Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; 4-chloro benzoate

no reactions.

Physical Data (1)

1

no reactions.

Physical Data (1)

1

Reaxys Registry Number: 6102966

Type of Substance: isocyclic Molecular Formula: C7H5ClO2*C10H15N Linear Structure Formula: C10H15N*C7H5ClO2

Molecular Weight: 305.804

InChI Key: XBLJNBMHELHIBZ-FVGYRXGTSA-N 102

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; 4-chloro benzoate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; 4-Chlor-benzoat Physical Data Melting Point (1) Melting Point

Reference

90 °C

Chiang; Li

Journal of the Chinese Chemical Society (Peking), 1951 , vol. 18, p. 161 Full Text Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; 2-chloro benzoate Reaxys Registry Number: 6121697

Type of Substance: isocyclic Molecular Formula: C7H5ClO2*C10H15N Linear Structure Formula: C10H15N*C7H5ClO2

Molecular Weight: 305.804

InChI Key: DBOYAFWLKMNWGS-FVGYRXGTSA-N 103

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; 2-chloro benzoate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; 2-Chlor-benzoat Physical Data Melting Point (1) Melting Point

Reference

93 - 95 °C

Chiang; Li

Journal of the Chinese Chemical Society (Peking), 1951 , vol. 18, p. 161 Full Text Show Details

Chemical Name: methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; 2-chloro benzoate

no reactions.

Physical Data (1)

1

Reaxys Registry Number: 6121698

Type of Substance: isocyclic Molecular Formula: C7H5ClO2*C10H15N Linear Structure Formula: C10H15N*C7H5ClO2

Molecular Weight: 305.804

InChI Key: DBOYAFWLKMNWGS-SBSPUUFOSA-N 104

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; 2-chloro benzoate, Methyl-((R)-1-methyl-2-phenyl-aethyl)-amin; 2-Chlor-benzoat Physical Data Melting Point (1) Melting Point

Reference

94 - 96 °C

Chiang; Li

Journal of the Chinese Chemical Society (Peking), 1951 , vol. 18, p. 161 Full Text Show Details

Chemical Name: methamphetamine, nicotine Reaxys Registry Number: 30194874

Molecular Formula: C10H14N2*C10H15N Linear Structure Formula: C10H14N2*C10H15N Molecular Weight: 311.47

InChI Key: LGKOEWOISUIUOT-PPHPATTJSA-N 105

no reactions.

1

Synthesize | Hide Details Find similar Chemical Names and Synonyms methamphetamine, nicotine Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; 4-nitro benzoate

no reactions.

Physical Data (4)

Reaxys Registry Number: 6103955

Type of Substance: isocyclic Molecular Formula: C7H5NO4*C10H15N Linear Structure Formula: C10H15N*C7H5NO4

Molecular Weight: 316.357

InChI Key: IUJVWZVIBWYPPQ-FVGYRXGTSA-N 106

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; 4-nitro benzoate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; 4-Nitro-benzoat Physical Data Melting Point (2) Melting Point

Solvent (Melting Point)

Reference

112 - 113 °C

diethyl ether

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

112 - 113 °C

acetone

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

Optical Rotatory Power (2) Type (Optical Rotatory Power)

Concentration (Optical Rotatory Power)

Solvent (Optical Rotatory Power)

Optical Rotatory Power

Wavelength (Optical Rotatory Power)

Temperature (Optical Rotatory Power)

[alpha]

c=0.8

ethanol

-7.9 deg

589 nm

23 °C

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

[alpha]

c=0.8

H2O

6.3 deg

589 nm

23 °C

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

Reference

1

Chemical Name: meth amphetamine

no reactions.

5

Reaxys Registry Number: 30138015

Molecular Formula: C9H13N*C10H15N*ClH Linear Structure Formula: C9H13N*C10H15N*ClH Molecular Weight: 320.906

InChI Key: NTUUZNGYUKZLOZ-WWPIYYJJSA-N 107

Synthesize | Hide Details Find similar Chemical Names and Synonyms meth amphetamine Chemical Name: dl-methamphetamine diliturate

no reactions.

Physical Data (3)

1

no reactions.

Physical Data (1)

1

Reaxys Registry Number: 6762990

Type of Substance: heterocyclic Molecular Formula: C4H3N3O5*C10H15N Linear Structure Formula: C10H15N*C4H3N3O5

Molecular Weight: 322.321

InChI Key: MNKHGIDBFQAUMO-UHFFFAOYSA-N 108

Synthesize | Hide Details Find similar Chemical Names and Synonyms dl-methamphetamine diliturate Physical Data Crystal Phase (1) Description (Crystal Phase)

Reference

Crystal habit

Julian; Plein

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 6 p. 704 - 707 Title/Abstract Full Text View citing articles Show Details

Crystal System (1) Crystal System

Reference

monoclinic

Julian; Plein

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 6 p. 704 - 707 Title/Abstract Full Text View citing articles Show Details

Optics (1) Description (Optics)

Reference

Crystal refractive indices

Julian; Plein

Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 6 p. 704 - 707 Title/Abstract Full Text View citing articles Show Details

Chemical Name: methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; (S)-α-bromo isovalerate

Reaxys Registry Number: 6121109

Type of Substance: isocyclic Molecular Formula: C5H9BrO2*C10H15N Linear Structure Formula: C10H15N*C5H9BrO2

Molecular Weight: 330.265

InChI Key: GWBFJLCROABIFN-VBZMPERESA-N

109

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; (S)-α-bromo isovalerate, Methyl-((R)-1-methyl-2-phenyl-aethyl)-amin; (S)-α-Brom-isovalerat Physical Data Melting Point (1) Melting Point

Solvent (Melting Point)

Reference

96 - 97 °C

H2O

Senoh

Yakugaku Zasshi, 1951 , vol. 71, p. 798 Chem.Abstr., 1952 , p. 2501 Full Text Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; (R)-α-bromo isovalerate

no reactions.

Physical Data (1)

1

no reactions.

Bioactivity (3)

3

Reaxys Registry Number: 6121110

Type of Substance: isocyclic Molecular Formula: C5H9BrO2*C10H15N Linear Structure Formula: C10H15N*C5H9BrO2

Molecular Weight: 330.265

InChI Key: GWBFJLCROABIFN-AGAVTAENSA-N

110

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; (R)-α-bromo isovalerate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; (R)-α-Brom-isovalerat Physical Data Melting Point (1) Melting Point

Reference

96 - 97 °C

Senoh

Yakugaku Zasshi, 1951 , vol. 71, p. 798 Chem.Abstr., 1952 , p. 2501 Full Text Show Details

Chemical Name: dextromethamphetamine hydrochloride Reaxys Registry Number: 9418777

Type of Substance: isocyclic Molecular Formula: 2C10H15N*ClH Linear Structure Formula: 2C10H15N*ClH Molecular Weight: 334.933

InChI Key: TWXDDNPPQUTEOV-FVGYRXGTSA-N

111

Synthesize | Hide Details Find similar Chemical Names and Synonyms dextromethamphetamine hydrochloride, METH methamphetamine Bioactivity Pharmacological Data (3) 1 of 3

2 of 3

Comment (Pharmacological Data)

Bioactivities present

Reference

Shappell, Scott A.; Kearns, Gregory L.; Valentine, Jimmie L.; Neri, David F.; DeJohn, Charles A.

Journal of Clinical Pharmacology, 1996 , vol. 36, # 11 p. 1051 - 1063 Title/Abstract Full Text View citing articles Show Details

Klupczynska, Agnieszka; Dereziński, Paweł; Krysztofiak, Janusz; Kokot, Zenon J.

Forensic Science International, 2016 , vol. 260, p. 14 - 21 Title/Abstract Full Text View citing articles Show Details

Jafari Giv, Mahsa

Cardiovascular Toxicology, 2017 , vol. 17, # 1 p. 13 - 24 Title/Abstract Full Text Show Details

Effect (Pharmacological Data)

pharmacokinetics

Species or TestSystem (Pharmacological Data)

human

Sex

male

Route of Application

peroral

Concentration (Pharmacological Data)

30 mg/70kg

Kind of Dosing (Pharmacological Data)

title comp. administered at 8:40 AM (day session) or 8:40 PM (night session)

Method (Pharmacological Data)

10 healthy subjects; methamphetamine levels of serum and urine determined by GC/MS method; Cmax, Tmax, Ka, Ke, AUC, Clt, Clr, Vd

Further Details (Pharmacological Data)

Cmax is the peak conc of methamphetamine, Tmax its time; Ka and Ke are absorption and elimination rate constants; Clt and Clr are total and renal clearance; Vd=steady-state volume of distribution

Half-life Time (Pharmacological Data)

9.11 - 10.81 h

Results

serum conc.-time diagram given; kinetic data for day and night sessions in tables and diagrams; no differences in day-vs.-night kinetic profile

Metabolite (Pharmacological Data)

dexamfetamine [Reaxys RN: 2205872]

Reference

Shappell, Scott A.; Kearns, Gregory L.; Valentine, Jimmie L.; Neri, David F.; DeJohn, Charles A.

Journal of Clinical Pharmacology, 1996 , vol. 36, # 11 p. 1051 - 1063 Title/Abstract Full Text View citing articles Show Details

3 of 3

Effect (Pharmacological Data)

behavioural symptoms

Species or TestSystem (Pharmacological Data)

human

Sex

male

Route of Application

peroral

Concentration (Pharmacological Data)

30 mg/70kg

Kind of Dosing (Pharmacological Data)

title comp. administered at 8:40 AM (day session) or 8:40 PM (night session)

Method (Pharmacological Data)

10 healthy subjects; recognitive performance (auditory divided attention, spatial memory, psychomotor tasks) subjective fatigue scale determined during 6:30 AM - 9:00 PM (day session) and 6:30 PM - 9:00 AM (night session); blood pressures measured

Results

no correlation between behavioral parameters and serum methamphetamine levels; diastolic and systolic blood pressures vs. time diagrams showed maxima

Reference

Shappell, Scott A.; Kearns, Gregory L.; Valentine, Jimmie L.; Neri, David F.; DeJohn, Charles A.

Journal of Clinical Pharmacology, 1996 , vol. 36, # 11 p. 1051 - 1063 Title/Abstract Full Text View citing articles Show Details

Chemical Name: D,L-Methylamphetamin-p-chlorphenoxyacetat Reaxys Registry Number: 4076518

CAS Registry Number: 98739-95-8 Type of Substance: isocyclic Molecular Formula: C8H7ClO3*C10H15N Linear Structure Formula: C10H15N*C8H7ClO3

Molecular Weight: 335.831

InChI Key: GEPDUXWJAAGKEP-UHFFFAOYSA-N

112

1 prep out of 1 reactions.

Physical Data (1)

1

no reactions.

Identification Physical Data (1) Spectra (4)

1

Synthesize | Hide Details Find similar Chemical Names and Synonyms D,L-Methylamphetamin-p-chlorphenoxyacetat Physical Data Melting Point (1) Melting Point

Reference

81 °C

Laboratoire d'Analyses et de Recherches Biologiques Mauvernay; C.E.R.M.

Patent: BE639286 , 1962 ; Chem.Abstr., 1965 , vol. 62, # 11738b Full Text Show Details

Reaxys Registry Number: 10612519

Type of Substance: heterocyclic Molecular Formula: C9H12N2O4*C10H15N Linear Structure Formula: C10H15N*C9H12N2O4

Molecular Weight: 361.441

InChI Key: DWYKRVKDMLFZGE-FVGYRXGTSA-N

113

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Identification Substance Label (1) Label

Reference

4 <H&-1%L>2<R1NMeH2>2

Reviriego, Felipe; Rodriguez-Franco, Maria Isabel; Navarro, Pilar; Garcia-Espana, Enrique; Liu-Gonzalez, Malva; Verdejo, Begona; Domenech, Antonio

Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16458 - 16459 Title/Abstract Full Text View citing articles Show Details

Physical Data Melting Point (1) Melting Point

Reference

83 - 85 °C

Reviriego, Felipe; Rodriguez-Franco, Maria Isabel; Navarro, Pilar; Garcia-Espana, Enrique; Liu-Gonzalez, Malva; Verdejo, Begona; Domenech, Antonio

Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16458 - 16459 Title/Abstract Full Text View citing articles Show Details

Spectra NMR Spectroscopy (2) Description (NMR Spectroscopy)

Nucleus (NMR Spectroscopy)

Solvents (NMR Spectroscopy)

Frequency (NMR Spectroscopy)

Chemical shifts

1H

dimethylsulfoxided6

500 MHz

Reviriego, Felipe; Rodriguez-Franco, Maria Isabel; Navarro, Pilar; Garcia-Espana, Enrique; Liu-Gonzalez, Malva; Verdejo, Begona; Domenech, Antonio

Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16458 - 16459 Title/Abstract Full Text View citing articles Show Details

Chemical shifts

13C

dimethylsulfoxided6

125 MHz

Reviriego, Felipe; Rodriguez-Franco, Maria Isabel; Navarro, Pilar; Garcia-Espana, Enrique; Liu-Gonzalez, Malva; Verdejo, Begona; Domenech, Antonio

Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16458 - 16459 Title/Abstract Full Text View citing articles Show Details

Reference

IR Spectroscopy (1) Description (IR Spectroscopy)

Solvent (IR Spectroscopy)

Bands

KBr

Reference Reviriego, Felipe; Rodriguez-Franco, Maria Isabel; Navarro, Pilar; Garcia-Espana, Enrique; Liu-Gonzalez, Malva; Verdejo, Begona; Domenech, Antonio

Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16458 - 16459 Title/Abstract Full Text View citing articles Show Details

Mass Spectrometry (1) Description (Mass Spectrometry) fast atom bombardment (FAB) spectrum

Reference Reviriego, Felipe; Rodriguez-Franco, Maria Isabel; Navarro, Pilar; Garcia-Espana, Enrique; Liu-Gonzalez, Malva; Verdejo, Begona; Domenech, Antonio

Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16458 - 16459 Title/Abstract Full Text View citing articles Show Details

Chemical Name: (+-)-methyl-(1-methyl-2-phenyl-ethyl)-amine; picrate

114

Reaxys Registry Number: 6113532

CAS Registry Number: 13857-60-8, 59920-95-5 Type of Substance: isocyclic Molecular Formula: C6H3N3O7*C10H15N Linear Structure Formula: C10H15N*C6H3N3O7

Molecular Weight: 378.342

InChI Key: OPLMVANOTUKEPS-UHFFFAOYSA-N

no reactions.

Physical Data (4)

3

Synthesize | Hide Details Find similar Chemical Names and Synonyms (+-)-methyl-(1-methyl-2-phenyl-ethyl)-amine; picrate, (+-)-Methyl-(1-methyl-2-phenyl-aethyl)-amin; Picrat Physical Data Melting Point (3) Melting Point

Solvent (Melting Point)

Reference

122 °C

methanol

Abe

Yakugaku Zasshi, 1955 , vol. 75, p. 159,162 Chem.Abstr., 1956 , p. 1779 Full Text Show Details

126 °C

H2O

Evdokimoff

Gazzetta Chimica Italiana, 1947 , vol. 77, p. 318,323,325 Full Text Show Details

128 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Crystal Property Description (1) Colour & Other Properties

Reference

gelb

Abe

Yakugaku Zasshi, 1955 , vol. 75, p. 159,162 Chem.Abstr., 1956 , p. 1779 Full Text Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; picrate Reaxys Registry Number: 6113533

CAS Registry Number: 13857-60-8, 59920-95-5 Type of Substance: isocyclic Molecular Formula: C6H3N3O7*C10H15N Linear Structure Formula: C10H15N*C6H3N3O7

Molecular Weight: 378.342

InChI Key: OPLMVANOTUKEPS-FVGYRXGTSA-N

115

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; picrate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; Picrat, D-desoxyephedrine picrate Physical Data

1 prep out of 1 reactions.

Physical Data (2) Spectra (1)

3

Melting Point (2) Melting Point

Reference

145.7 - 147.1 °C

Chatten; Levi

Analytical Chemistry, 1959 , vol. 31, p. 1581,1582,1585 Full Text View citing articles Show Details

144 - 145 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Spectra IR Spectroscopy (1) Description (IR Spectroscopy)

Solvent (IR Spectroscopy)

Comment (IR Spectroscopy)

Reference

Spectrum

KBr

4000 - 650 cm**(-1)

Chatten; Levi

Analytical Chemistry, 1959 , vol. 31, p. 1581,1582,1585 Full Text View citing articles Show Details

Chemical Name: methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; picrate

no reactions.

Physical Data (1)

1

no reactions.

Physical Data (1)

1

Reaxys Registry Number: 6113534

CAS Registry Number: 59920-95-5 Type of Substance: isocyclic Molecular Formula: C6H3N3O7*C10H15N Linear Structure Formula: C10H15N*C6H3N3O7

Molecular Weight: 378.342

InChI Key: OPLMVANOTUKEPS-SBSPUUFOSA-N

116

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; picrate, Methyl-((R)-1-methyl-2-phenyl-aethyl)-amin; Picrat Physical Data Melting Point (1) Melting Point

Reference

144 - 145 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amin; (1S)-2-oxo-bornane10-sulfonate Reaxys Registry Number: 6113089

Type of Substance: isocyclic Molecular Formula: C10H15N*C10H16O4S Linear Structure Formula: C10H16O4S*C10H15N Molecular Weight: 381.536

InChI Key: SLORXCQEJDMGNH-LIGZPJPGSA-N

117

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Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amin; (1S)-2-oxo-bornane-10-sulfonate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; (1S)-2-Oxo-bornan-10sulfonat Physical Data Melting Point (1) Melting Point

Reference

124 - 125 °C

Chiang; Li

Journal of the Chinese Chemical Society (Peking), 1951 , vol. 18, p. 161 Full Text Show Details

Chemical Name: methyl-((R)-1-methyl-2-phenyl-ethyl)-amin; (1S)-2-oxo-bornane10-sulfonate

no reactions.

Physical Data (1)

1

no reactions.

1

no reactions.

Physical Data (8)

1

Reaxys Registry Number: 6113090

Type of Substance: isocyclic Molecular Formula: C10H15N*C10H16O4S Linear Structure Formula: C10H16O4S*C10H15N Molecular Weight: 381.536

InChI Key: SLORXCQEJDMGNH-GUIHCAGKSA-N

118

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((R)-1-methyl-2-phenyl-ethyl)-amin; (1S)-2-oxo-bornane-10-sulfonate, Methyl-((R)-1-methyl-2-phenyl-aethyl)-amin; (1S)-2-Oxo-bornan-10sulfonat Physical Data Melting Point (1) Melting Point

Reference

124 - 125 °C

Chiang; Li

Journal of the Chinese Chemical Society (Peking), 1951 , vol. 18, p. 161 Full Text Show Details

Chemical Name: tional ice Reaxys Registry Number: 30246026

Molecular Formula: C8H18O4S2*C10H15N Linear Structure Formula: C8H18O4S2*C10H15N Molecular Weight: 391.596

InChI Key: KQLZLQDGXVVCNC-FVGYRXGTSA-N

119

Synthesize | Hide Details Find similar Chemical Names and Synonyms tional ice Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; sulfate

Reaxys Registry Number: 6100466

CAS Registry Number: 17086-30-5, 20189-61-1, 28297-73-6, 28297-74-7, 58670-90-9 Type of Substance: isocyclic Molecular Formula: 2C10H15N*H2O4S Linear Structure Formula: 2C10H15N*H2O4S Molecular Weight: 396.551

InChI Key: SOBAVQRLBCJNQT-FVGYRXGTSA-N

120

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; sulfate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; Sulfat Physical Data Melting Point (2) Melting Point

Solvent (Melting Point)

Reference

124 - 125 °C

ethanol

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

124 - 125 °C

acetone

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

Optical Rotatory Power (6) Type (Optical Rotatory Power)

Concentration (Optical Rotatory Power)

Solvent (Optical Rotatory Power)

Optical Rotatory Power

Wavelength (Optical Rotatory Power)

Temperature (Optical Rotatory Power)

[alpha]

c=2

ethanol

-10.6 deg

589 nm

20 °C

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

[alpha]

c=4

ethanol

-10.3 deg

589 nm

29 °C

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

[alpha]

c=2

methanol

-7.8 deg

589 nm

24 °C

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

[alpha]

c=2

H2O

12.6 deg

589 nm

20 °C

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

[alpha]

c=4

H2O

12.5 deg

589 nm

29 °C

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

[alpha]

c=0.2

CHCl3

-13.9 deg

589 nm

16 °C

Chiang

Journal of the Chinese Chemical Society (Peking), 1950 , vol. 17, p. 106,112 Full Text Show Details

Chemical Name: sulfanilic acid pyrimidin-2-ylamide; methyl-(1-methyl-2-phenylethyl)-amine salt

Reference

no reactions.

Physical Data (4)

1

Reaxys Registry Number: 3847059

Type of Substance: heterocyclic Molecular Formula: C10H10N4O2S*C10H15N Linear Structure Formula: C10H15N*C10H10N4O2S Molecular Weight: 399.517

InChI Key: QBVXTXBYXXJVCN-UHFFFAOYSA-N

121

Synthesize | Hide Details Find similar Chemical Names and Synonyms sulfanilic acid pyrimidin-2-ylamide; methyl-(1-methyl-2-phenyl-ethyl)-amine salt, Sulfanilsaeure-pyrimidin-2-ylamid; Methyl-(1-methyl-2-phenylaethyl)-amin-Salz Physical Data Melting Point (1) Melting Point

Reference

187 - 189 °C

Hamilton et al.

Journal of the American Pharmaceutical Association (1912-1977), 1944 , vol. 33, p. 142,143 Full Text Show Details

Crystal System (1) Crystal System

Reference

monoclinic

Hamilton et al.

Journal of the American Pharmaceutical Association (1912-1977), 1944 , vol. 33, p. 142,143 Full Text Show Details

Solubility (MCS) (2) Solubility

Saturation

Temperature (Solubility (MCS))

Solvent (Solubility (MCS))

Reference

12.5 g·l-1

in solution

2 °C

H2O

Hamilton et al.

Journal of the American Pharmaceutical Association (1912-1977), 1944 , vol. 33, p. 142,143 Full Text Show Details

15.2 g·l-1

in solution

30 °C

H2O

Hamilton et al.

Journal of the American Pharmaceutical Association (1912-1977), 1944 , vol. 33, p. 142,143 Full Text Show Details

Chemical Name: sulfanilic acid thiazol-2-ylamide; (+-)-methyl-(1-methyl-2-phenylethyl)-amine salt Reaxys Registry Number: 3843875

Type of Substance: heterocyclic Molecular Formula: C9H9N3O2S2*C10H15N Linear Structure Formula: C10H15N*C9H9N3O2S2

Molecular Weight: 404.557

InChI Key: IWDYBSBBBKFGMW-UHFFFAOYSA-N

122

Synthesize | Hide Details Find similar Chemical Names and Synonyms sulfanilic acid thiazol-2-ylamide; (+-)-methyl-(1-methyl-2-phenyl-ethyl)-amine salt, Sulfanilsaeure-thiazol-2-ylamid; (+-)-Methyl-(1-methyl-2-phenyl-

no reactions.

Physical Data (4)

1

aethyl)-amin-Salz Physical Data Melting Point (1) Melting Point

Reference

118 - 120 °C

Hamilton et al.

Journal of the American Pharmaceutical Association (1912-1977), 1944 , vol. 33, p. 142,143 Full Text Show Details

Crystal Property Description (1) Colour & Other Properties

Reference

monoklin

Hamilton et al.

Journal of the American Pharmaceutical Association (1912-1977), 1944 , vol. 33, p. 142,143 Full Text Show Details

Solubility (MCS) (2) Solubility

Saturation

Temperature (Solubility (MCS))

Solvent (Solubility (MCS))

Reference

11.9 g·l-1

in solution

2 °C

H2O

Hamilton et al.

Journal of the American Pharmaceutical Association (1912-1977), 1944 , vol. 33, p. 142,143 Full Text Show Details

16.7 g·l-1

in solution

30 °C

H2O

Hamilton et al.

Journal of the American Pharmaceutical Association (1912-1977), 1944 , vol. 33, p. 142,143 Full Text Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; picrolonate Reaxys Registry Number: 6113714

Type of Substance: heterocyclic Molecular Formula: C10H8N4O5*C10H15N Linear Structure Formula: C10H15N*C10H8N4O5

Molecular Weight: 413.433

InChI Key: CTZVWXXMDVEGAI-NPULLEENSA-N

123

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; picrolonate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; Picrolonat Physical Data Melting Point (1) Melting Point

Reference

183 °C

Dultz

Zeitschrift fuer Analytische Chemie, 1940 , vol. 120, p. 84,86 Full Text Show Details

Kofler,L. u. A.

Thermo-Mikro-Methoden, 3. Aufl.<Weinheim 1954>> S. 532 Full Text Show Details

Crystal Property Description (1) Colour & Other Properties

Reference

gelb

Dultz

Zeitschrift fuer Analytische Chemie, 1940 , vol. 120, p. 84,86 Full Text Show Details

no reactions.

Physical Data (2)

2

Kofler,L. u. A.

Thermo-Mikro-Methoden, 3. Aufl.<Weinheim 1954>> S. 532 Full Text Show Details

Chemical Name: DMI ice

no reactions.

2

no reactions.

Physical Data (1)

1

no reactions.

Identification Physical Data (1)

1

Reaxys Registry Number: 30235585

Molecular Formula: C10H15N*C18H22N2

Linear Structure Formula: C10H15N*C18H22N2

Molecular Weight: 415.622

InChI Key: JYLSUZICRFUDJS-NPULLEENSA-N

124

Synthesize | Hide Details Find similar Chemical Names and Synonyms DMI ice Chemical Name: 4,6,2'-trimethyl-3-methylen-4'-oxo-3H-spiro[benzofuran-2,1'cyclopent-2'-ene]-3'-carboxylic acid ; (+-)-2-methylamino-1phenyl-propane salt Reaxys Registry Number: 3854778

Type of Substance: heterocyclic Molecular Formula: C10H15N*C17H16O4

Linear Structure Formula: C17H16O4*C10H15N Molecular Weight: 433.547

InChI Key: XCZRBBXYDXMESM-UHFFFAOYSA-N

125

Synthesize | Hide Details Find similar Chemical Names and Synonyms 4,6,2'-trimethyl-3-methylen-4'-oxo-3H-spiro[benzofuran-2,1'-cyclopent-2'-ene]-3'-carboxylic acid ; (+-)-2-methylamino-1-phenyl-propane salt, 4,6,2'Trimethyl-3-methylen-4'-oxo-3H-spiro[benzofuran-2,1'-cyclopent-2'-en]-3'-carbonsaeure; (+-)-2-Methylamino-1-phenyl-propan-Salz Physical Data Melting Point (1) Melting Point

Solvent (Melting Point)

Reference

150 °C

benzene diethyl ether

Dean et al.

Journal of the Chemical Society, 1953 , p. 1250,1253 Journal of the Chemical Society, 1957 , p. 1577 Full Text Show Details

Chemical Name: (+-)-methyl-(1-methyl-2-phenyl-ethyl)-amine; trichloromercurate(II) Reaxys Registry Number: 6112741

Type of Substance: isocyclic Molecular Formula: C10H15N*Cl3Hg*H Linear Structure Formula: C10H15N*Cl3Hg(1-)*H(1+)

126

Molecular Weight: 457.193

InChI Key: KISDFACEDNITLX-UHFFFAOYSA-L

Synthesize | Hide Details Find similar Chemical Names and Synonyms (+-)-methyl-(1-methyl-2-phenyl-ethyl)-amine; trichloromercurate(II), (+-)-Methyl-(1-methyl-2-phenyl-aethyl)-amin; Trichloromercurat(II) Identification One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Hg{X}3

X

3

Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Hg{X}3

X

3

Multi-Center Ligands (1)

Physical Data Melting Point (1) Melting Point

Reference

128 - 130 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; trichloromercurate(II)

no reactions.

Reaxys Registry Number: 6112742

Type of Substance: isocyclic Molecular Formula: C10H15N*Cl3Hg*H Linear Structure Formula: C10H15N*Cl3Hg(1-)*H(1+)

Molecular Weight: 457.193

InChI Key: KISDFACEDNITLX-ZWACTXNCSA-L

127

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; trichloromercurate(II), Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; Trichloromercurat(II) Identification One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Hg{X}3

X

3

Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Hg{X}3

X

3

Multi-Center Ligands (1)

Physical Data

Identification Physical Data (1)

1

Melting Point (1) Melting Point

Reference

214 - 215 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Chemical Name: methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; trichloromercurate(II)

no reactions.

Reaxys Registry Number: 6112743

Type of Substance: isocyclic Molecular Formula: C10H15N*Cl3Hg*H Linear Structure Formula: C10H15N*Cl3Hg(1-)*H(1+)

Identification Physical Data (1)

1

Physical Data (1) Spectra (1)

1

Molecular Weight: 457.193

InChI Key: KISDFACEDNITLX-RASHCQHBSA-L

128

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; trichloromercurate(II), Methyl-((R)-1-methyl-2-phenyl-aethyl)-amin; Trichloromercurat(II) Identification One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Hg{X}3

X

3

Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Hg{X}3

X

3

Multi-Center Ligands (1)

Physical Data Melting Point (1) Melting Point

Reference

152 - 153 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; reineckate Reaxys Registry Number: 6111361

Type of Substance: isocyclic Molecular Formula: 4CNS*C10H15N*Cr*H*2H3N Linear Structure Formula: C10H15N*4CNS(1-

)*Cr(3+)*2H

129

N*H(1+)

3

Molecular Weight: 468.636

InChI Key: LJWJTASGTMGBRI-DXYFNVQQSA-N

Synthesize | Hide Details

no reactions.

Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; reineckate, Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; Reineckat Physical Data Melting Point (1) Melting Point

Solvent (Melting Point)

Reference

120.8 - 123.9 °C

aq. ethanol

Chatten; Levi

Analytical Chemistry, 1959 , vol. 31, p. 1581,1582,1585 Full Text View citing articles Show Details

Spectra IR Spectroscopy (1) Description (IR Spectroscopy)

Solvent (IR Spectroscopy)

Comment (IR Spectroscopy)

Reference

Spectrum

KBr

4000 - 650 cm**(-1)

Chatten; Levi

Analytical Chemistry, 1959 , vol. 31, p. 1581,1582,1585 Full Text View citing articles Show Details

Chemical Name: Methamphetamin-tetraphenylborat Reaxys Registry Number: 6311962

Type of Substance: isocyclic Molecular Formula: C10H15N*C24H20B*H Linear Structure Formula: C24H20B(1-)*C10H15N*H(1+)

Molecular Weight: 469.478

InChI Key: UVQXUSSMGDNJDH-NPULLEENSA-O

130

Synthesize | Hide Details Find similar Chemical Names and Synonyms Methamphetamin-tetraphenylborat Physical Data Melting Point (1) Melting Point

Reference

127 - 128 °C

SINSHEIMER; SMITH

Journal of pharmaceutical sciences, 1963 , vol. 52, p. 1080 - 1085 Title/Abstract Full Text View citing articles Show Details

Spectra IR Spectroscopy (1) Description (IR Spectroscopy)

Reference

Spectrum

SINSHEIMER; SMITH

Journal of pharmaceutical sciences, 1963 , vol. 52, p. 1080 - 1085 Title/Abstract Full Text View citing articles Show Details

UV/VIS Spectroscopy (2) Description (UV/VIS Spectroscopy)

Reference

Spectrum

SINSHEIMER; SMITH

no reactions.

Physical Data (1) Spectra (3)

1

Journal of pharmaceutical sciences, 1963 , vol. 52, p. 1080 - 1085 Title/Abstract Full Text View citing articles Show Details

Absorption maxima

SINSHEIMER; SMITH

Journal of pharmaceutical sciences, 1963 , vol. 52, p. 1080 - 1085 Title/Abstract Full Text View citing articles Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; tetrachloroaurate (III)

no reactions.

Reaxys Registry Number: 6112739

Type of Substance: isocyclic Molecular Formula: AuCl4*C10H15N*H Linear Structure Formula: C10H15N*AuCl4(1-)*H(1+)

Molecular Weight: 489.022

InChI Key: STXJZSIETYQJNY-SADGAIANSA-K

131

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; tetrachloroaurate (III), Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; Tetrachloroaurat(III) Identification One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Au{X}4

X

4

Multi-Center Ligands (1) Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Au{X}4

X

4

Physical Data Melting Point (2) Melting Point

Solvent (Melting Point)

Reference

127 - 128 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

126 °C

aq. HCl

Schmidt

Archiv der Pharmazie (Weinheim, Germany), 1914 , vol. 252, p. 121 Archiv der Pharmazie (Weinheim, Germany), 1915 , vol. 253, p. 52 Full Text Show Details

Crystal Property Description (1) Colour & Other Properties

Reference

rotgelbe Nadeln

Schmidt

Archiv der Pharmazie (Weinheim, Germany), 1914 , vol. 252, p. 121 Archiv der Pharmazie (Weinheim, Germany), 1915 , vol. 253, p. 52 Full Text Show Details

Optics (1) Description (Optics)

Reference

Identification Physical Data (4)

3

Keenan

Journal of the American Pharmaceutical Association (1912-1977), 1949 , vol. 38, p. 314 Chem.Abstr., 1949 , p. 8611 Full Text Show Details

Crystal refractive indices

Chemical Name: methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; tetrachloroaurate (III)

no reactions.

Reaxys Registry Number: 6112740

Type of Substance: isocyclic Molecular Formula: AuCl4*C10H15N*H Linear Structure Formula: C10H15N*AuCl4(1-)*H(1+)

Identification Physical Data (1)

1

Identification Physical Data (4)

3

Molecular Weight: 489.022

InChI Key: STXJZSIETYQJNY-NMPKWJFPSA-K

132

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; tetrachloroaurate (III), Methyl-((R)-1-methyl-2-phenyl-aethyl)-amin; Tetrachloroaurat(III) Identification One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Au{X}4

X

4

Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Au{X}4

X

4

Multi-Center Ligands (1)

Physical Data Melting Point (1) Melting Point

Reference

127 - 128 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Chemical Name: (+-)-methyl-(1-methyl-2-phenyl-ethyl)-amine; tetrachloroaurate (III) Reaxys Registry Number: 6112963

Type of Substance: isocyclic Molecular Formula: AuCl4*C10H15N*H Linear Structure Formula: C10H15N*AuCl4(1-)*H(1+)

Molecular Weight: 489.022

InChI Key: STXJZSIETYQJNY-UHFFFAOYSA-K

133

Synthesize | Hide Details Find similar Chemical Names and Synonyms

no reactions.

(+-)-methyl-(1-methyl-2-phenyl-ethyl)-amine; tetrachloroaurate (III), (+-)-Methyl-(1-methyl-2-phenyl-aethyl)-amin; Tetrachloroaurat(III) Identification One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Au{X}4

X

4

Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Au{X}4

X

4

Multi-Center Ligands (1)

Physical Data Melting Point (2) Melting Point

Reference

103 - 104 °C

Jacobsen et al.

Skand.Arch.Physiol., 1938 , vol. 79, p. 258,278 Full Text Show Details

108 - 109 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Crystal Property Description (1) Colour & Other Properties

Reference

Nadeln

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Optics (1) Description (Optics)

Reference

Crystal refractive indices

Keenan

Journal of the American Pharmaceutical Association (1912-1977), 1949 , vol. 38, p. 314 Chem.Abstr., 1949 , p. 8611 Full Text Show Details

Chemical Name: ((+)-methamphetamine(+1H))AuCl4

Reaxys Registry Number: 23678276

Molecular Formula: AuCl4*C10H15N*H Linear Structure Formula: AuCl4(1-)*H(1+)*C10H15N Molecular Weight: 489.022

InChI Key: QUDKYMBGLIGJEQ-SADGAIANSA-K

134

Synthesize | Hide Details Find similar Chemical Names and Synonyms ((+)-methamphetamine(+1H))AuCl4, D-methyl(1-phenylpropan-2-yl)azanium tetrachloridoaurate(III) Identification

1 prep out of 1 reactions.

Identification Physical Data (6)

1

One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Au{X}4

X

4

Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Au{X}4

X

4

Multi-Center Ligands (1)

Substance Label (1) Label

Reference

2

Wood, Matthew R.; Lalancette, Roger A.

Acta Crystallographica Section C: Crystal Structure Communications, 2013 , vol. 69, # 4 p. 388 - 393 Title/Abstract Full Text View citing articles Show Details

Physical Data Density (1)

Measurement Temperature

Type (Density)

Reference

-173.16 °C

crystallographic

Wood, Matthew R.; Lalancette, Roger A.

Acta Crystallographica Section C: Crystal Structure Communications, 2013 , vol. 69, # 4 p. 388 - 393 Title/Abstract Full Text View citing articles Show Details

Conformation (1) Object of Investigation

Reference

Conformation

Wood, Matthew R.; Lalancette, Roger A.

Acta Crystallographica Section C: Crystal Structure Communications, 2013 , vol. 69, # 4 p. 388 - 393 Title/Abstract Full Text View citing articles Show Details

Crystal Phase (1) Description (Crystal Phase)

Reference

Structure of the solid

Wood, Matthew R.; Lalancette, Roger A.

Acta Crystallographica Section C: Crystal Structure Communications, 2013 , vol. 69, # 4 p. 388 - 393 Title/Abstract Full Text View citing articles Show Details

Crystal System (1) Crystal System

Reference

Monoclinic

Wood, Matthew R.; Lalancette, Roger A.

Acta Crystallographica Section C: Crystal Structure Communications, 2013 , vol. 69, # 4 p. 388 - 393 Title/Abstract Full Text View citing articles Show Details

Interatomic Distances and Angles (1) Description

Comment (Interatomic Distances and Angles)

Reference

Interatomic distances and angles

Single Crystal X-ray Diffraction

Wood, Matthew R.; Lalancette, Roger A.

Acta Crystallographica Section C: Crystal Structure Communications, 2013 , vol. 69, # 4 p. 388 - 393 Title/Abstract Full Text View citing articles Show Details

Space Group (1) Space Group 4

Comment (Space Group)

Reference

a = 7.3561 Å; b = 14.2394 Å; c = 13.9103 Å; β = 90.077 °; Z = 4; T = 100 K; Method = Single crystal X-ray diffraction

Wood, Matthew R.; Lalancette, Roger A.

Acta Crystallographica Section C: Crystal Structure Communications, 2013 , vol. 69, # 4 p. 388 - 393 Title/Abstract Full Text View citing articles Show Details

Chemical Name: sugar Ice

no reactions.

1

no reactions.

1

no reactions.

1

no reactions.

Identification Physical Data (1)

1

Reaxys Registry Number: 30263903

Molecular Formula: C10H15N*C12H22O11

Linear Structure Formula: C10H15N*C12H22O11

Molecular Weight: 491.536

InChI Key: KBUPNXGUGPYWDR-OYHRRBSVSA-N

135

Synthesize | Hide Details Find similar Chemical Names and Synonyms sugar Ice Chemical Name: Lactulose Meth Reaxys Registry Number: 30653560

Molecular Formula: C10H15N*C12H22O11*ClH Linear Structure Formula: C10H15N*C12H22O11*ClH Molecular Weight: 527.997

InChI Key: DONMZGSUCKNXPY-TVCRJLEPSA-N

136

Synthesize | Hide Details Find similar Chemical Names and Synonyms Lactulose Meth Chemical Name: naled ice Reaxys Registry Number: 30656156

Molecular Formula: C4H7Br2Cl2O4P*C10H15N Linear Structure Formula: C4H7Br2Cl2O4P*C10H15N Molecular Weight: 530.021

InChI Key: NUHJIWCEEFLQKM-FVGYRXGTSA-N

137

Synthesize | Hide Details Find similar Chemical Names and Synonyms naled ice Chemical Name: methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; hexachloroplatinate (IV) Reaxys Registry Number: 6106611

Type of Substance: isocyclic Molecular Formula: C10H15N*Cl6Pt*2H

Linear Structure Formula: C10H15N*Cl6Pt(2-)*2H(1+)

Molecular Weight: 559.05

InChI Key: XWILRAAJAXLUOY-AGGFLZQHSA-I

138

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((R)-1-methyl-2-phenyl-ethyl)-amine; hexachloroplatinate (IV), Methyl-((R)-1-methyl-2-phenyl-aethyl)-amin; Hexachloroplatinat(IV) Identification One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Pt{X}6

X

6

Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Pt{X}6

X

6

Multi-Center Ligands (1)

Physical Data Melting Point (1) Melting Point

Reference

214 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Chemical Name: ICE CER

no reactions.

1

no reactions.

1

Reaxys Registry Number: 30656299

Molecular Formula: C10H15N*C19H17N3O4S2

Linear Structure Formula: C10H15N*C19H17N3O4S2

Molecular Weight: 564.729

InChI Key: WYMQJCVUNPAODO-RWPRVABESA-N

139

Synthesize | Hide Details Find similar Chemical Names and Synonyms ICE CER Chemical Name: Methamphetamine Cocaine Amyl nitrite Reaxys Registry Number: 30638355

Molecular Formula: C5H11NO2*C10H15N*C17H21NO4

Linear Structure Formula: C5H11NO2*C10H15N*C17H21NO4

Molecular Weight: 569.742

InChI Key: HPHYMVOZGOQJEB-NVDOTFARSA-N

140

Synthesize | Hide Details Find similar Chemical Names and Synonyms Methamphetamine Cocaine Amyl nitrite Chemical Name: acrylamide, stearyl meth acrylate

no reactions.

1

no reactions.

Identification Physical Data (4)

3

Reaxys Registry Number: 30265098

Molecular Formula: C3H5NO*C10H15N*C21H40O2*ClH Linear Structure Formula: C3H5NO*C10H15N*C21H40O2*ClH Molecular Weight: 581.323

InChI Key: FAXCOLXZPYKTSG-DBQHITQZSA-N

141

Synthesize | Hide Details Find similar Chemical Names and Synonyms acrylamide, stearyl meth acrylate Chemical Name: (+-)-methyl-(1-methyl-2-phenyl-ethyl)-amine; hexachloroplatinate (IV) Reaxys Registry Number: 6113295

Type of Substance: isocyclic Molecular Formula: 2C10H15N*Cl6Pt*2H Linear Structure Formula: 2C10H15N*Cl6Pt(2-)*2H(1+)

Molecular Weight: 708.285

InChI Key: XWILRAAJAXLUOY-UHFFFAOYSA-I

142

Synthesize | Hide Details Find similar Chemical Names and Synonyms (+-)-methyl-(1-methyl-2-phenyl-ethyl)-amine; hexachloroplatinate (IV), (+-)-Methyl-(1-methyl-2-phenyl-aethyl)-amin; Hexachloroplatinat(IV) Identification One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Pt{X}6

X

6

Multi-Center Ligands (1) Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Pt{X}6

X

6

Physical Data Melting Point (3) Melting Point

Reference

198 °C

Asklepia A.G.

Patent: CH233303 , 1942 ; Full Text Show Details

198 - 199 °C

Erlenmeyer; Simon

Helvetica Chimica Acta, 1942 , vol. 25, p. 528 Full Text Show Details

205 °C

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Crystal Property Description (1) Colour & Other Properties

Reference

orangegelbe Prismen

Ogata

Yakugaku Zasshi, 1919 , # 451 p. 751 Chem.Abstr., 1920 , vol. 14, p. 745 Full Text Show Details

Chemical Name: methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; hexachloroplatinate (IV)

no reactions.

Reaxys Registry Number: 6113296

Type of Substance: isocyclic Molecular Formula: 2C10H15N*Cl6Pt*2H Linear Structure Formula: 2C10H15N*Cl6Pt(2-)*2H(1+)

Molecular Weight: 708.285

InChI Key: XWILRAAJAXLUOY-UDXRYNAFSA-I

143

Synthesize | Hide Details Find similar Chemical Names and Synonyms methyl-((S)-1-methyl-2-phenyl-ethyl)-amine; hexachloroplatinate (IV), Methyl-((S)-1-methyl-2-phenyl-aethyl)-amin; Hexachloroplatinat(IV) Identification One-Center Ligands (1) Base Formula (One-Center Ligands)

Formula (One-Center Ligands)

Count (One-Center Ligands)

Pt{X}6

X

6

Base Formula (Multi-Center Ligands)

Formula (Multi-Center Ligands)

Count (Multi-Center Ligands)

Pt{X}6

X

6

Multi-Center Ligands (1)

Identification Physical Data (2)

1

Physical Data Melting Point (1) Melting Point

Solvent (Melting Point)

Reference

208 - 209 °C

aq. HCl

Schmidt

Archiv der Pharmazie (Weinheim, Germany), 1914 , vol. 252, p. 121 Archiv der Pharmazie (Weinheim, Germany), 1915 , vol. 253, p. 52 Full Text Show Details

Crystal Property Description (1) Colour & Other Properties

Reference

rotgelbe Nadeln

Schmidt

Archiv der Pharmazie (Weinheim, Germany), 1914 , vol. 252, p. 121 Archiv der Pharmazie (Weinheim, Germany), 1915 , vol. 253, p. 52 Full Text Show Details

Chemical Name: HEM ice

no reactions.

1

no reactions.

Identification Spectra (1)

1

Reaxys Registry Number: 30828678

Molecular Formula: C10H15N*C34H32N4O4*Fe Linear Structure Formula: C10H15N*C34H32N4O4(2-)*Fe(2+)

Molecular Weight: 765.735

InChI Key: AFVDBWSUKVVQQO-MABAWFGTSA-L

144

Synthesize | Hide Details Find similar Chemical Names and Synonyms HEM ice Reaxys Registry Number: 27418543

Molecular Formula: C10H15N*C68H68O8P4S4*ClH Linear Structure Formula: C68H68O8P4S4*C10H15N*ClH Molecular Weight: 1451.14

InChI Key: KQYNVQPLZSXHKI-UHFFFAOYSA-N

145

Synthesize | Hide Details Find similar

Identification Substance Label (1) Label

Reference

TSiiii+Methamphetamine

Biavardi, Elisa; Menozzi, Daniela; Massera, Chiara; Dalcanale, Enrico; Federici, Stefania; Sottini, Andrea; Bergese, Paolo; Tudisco, Cristina; Condorelli, Guglielmo G.

Angewandte Chemie, International Edition, 2014 , vol. 53, # 35 p. 9183 - 9188,6 Angewandte Chemie, 2014 , vol. 126, # 35 p. 9337 - 9342,6 Title/Abstract Full Text View citing articles Show Details

Spectra

NMR Spectroscopy (1)

146

Description (NMR Spectroscopy)

Nucleus (NMR Spectroscopy)

Solvents (NMR Spectroscopy)

Temperature (NMR Spectroscopy)

Frequency (NMR Spectroscopy)

Spectrum

31P

chloroform-d1

24.84 °C

400 MHz

Location

Reference

supporting information

Biavardi, Elisa; Menozzi, Daniela; Massera, Chiara; Dalcanale, Enrico; Federici, Stefania; Sottini, Andrea; Bergese, Paolo; Tudisco, Cristina; Condorelli, Guglielmo G.

Angewandte Chemie, International Edition, 2014 , vol. 53, # 35 p. 9183 - 9188,6 Angewandte Chemie, 2014 , vol. 126, # 35 p. 9337 - 9342,6 Title/Abstract Full Text View citing articles Show Details

Chemical Name: (14)C carbon tetrachloride; methamphetamine; mixture of

mixture (composition partially given) :

(14)C carbon tetrachloride (R)-(-)-methamphetamine

no reactions.

Reaxys Registry Number: 8188771 Type of Substance: mixture (composition partially given)

Hide Details Chemical Names and Synonyms (14)C carbon tetrachloride; methamphetamine; mixture of Composition (14)C carbon tetrachloride

(R)-(-)-methamphetamine

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Bioactivity Pharmacological Data (2) 1 of 2

2 of 2

Comment (Pharmacological Data)

Bioactivities present

Reference

Roberts, Stephen M.; Harbison, Raymond D.; James, Robert C.

Toxicology, 1995 , vol. 97, # 1-3 p. 49 - 57 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hepatotoxic

Species or TestSystem (Pharmacological Data)

ICR mouse

Sex

male

Route of Application

intraperitoneal

Kind of Dosing (Pharmacological Data)

0.005 ml/kg, i.p. <(14)C>CCl4, 1 μCi; methamphetamine 15 mg/kg, i.p. in 10 ml/kg saline 3 h after CCl4 dose

Exposure Period

0 - 120 min

Bioactivity (2)

1

(Pharmacological Data)

147

Method (Pharmacological Data)

adult ICR mice; 5-10 male, 30-35 g; administr. <(14)C>CCl4; methamphetamine administr. 3 h after dose CCl4; killed 0-120 min after methamphetamine dose; liver removed; homogen.; covalent binding of radiolabel to proteins and lipids was measured by Sipes

Further Details (Pharmacological Data)

compared with <(14)C>CCl4 alone; results presented as graph as pmoles bound per mg protein or mg lipid

Results

at all time points covalent binding of CCl4 to lipids in methamphetamine-treated mice was less than in mice administr. CCl4; covalent binding CCl4 to proteins was signif. greater in mice 60 min after methamphetamine dose, but unchanged at other time

Reference

Roberts, Stephen M.; Harbison, Raymond D.; James, Robert C.

Toxicology, 1995 , vol. 97, # 1-3 p. 49 - 57 Title/Abstract Full Text View citing articles Show Details

Chemical Name: methamphetamine; carbon tetrachloride; mixture of

mixture (composition partially given) :

tetrachloromethane (R)-(-)-methamphetamine

no reactions.

Reaxys Registry Number: 8188772 Type of Substance: mixture (composition partially given)

Hide Details Chemical Names and Synonyms methamphetamine; carbon tetrachloride; mixture of Composition

(R)-(-)-methamphetamine

tetrachloromethane

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Bioactivity Pharmacological Data (3) 1 of 3

2 of 3

Comment (Pharmacological Data)

Bioactivities present

Reference

Roberts, Stephen M.; Harbison, Raymond D.; James, Robert C.

Toxicology, 1995 , vol. 97, # 1-3 p. 49 - 57 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

enzyme; examination of

Species or TestSystem (Pharmacological Data)

ICR mouse

Sex

male

Route of Application

intraperitoneal

Kind of Dosing (Pharmacological Data)

15 mg/kg, i.p. methamphetamine in 10 ml/kg saline; after 0 - 12 h 0.005 ml/kg, i.p. CCl4; control i.p. injection 10 ml/kg saline

Bioactivity (3)

1

3 of 3

148

Exposure Period (Pharmacological Data)

24 h

Method (Pharmacological Data)

adult ICR mice; 8-10 male, 30-35 g; administr. methamphetamine 15 mg/kg before (-3 h), with (0 h), or 3-12 h after dose CCl4 (0.005 ml/kg); killed; blood collected; necrogenic effect of title comp. assess. by serum alanine aminotransferase (ALT) activ.

Further Details (Pharmacological Data)

ALT activ. measured 24 h after CCl4 dose according to Bergmeyer; compared with control

Results

no signif. increas. in serum ALT activ. when methamphetamine cotreatment before 3 h or 6-12 h after dose CCl4(ca. 80-300 IU/l); cotreatm. methamphetamine with or 3 h after dose CCl4 signif. increas. ALT activ. (ca. 1080 or 1050 IU/l, resp.); control 24

Reference

Roberts, Stephen M.; Harbison, Raymond D.; James, Robert C.

Toxicology, 1995 , vol. 97, # 1-3 p. 49 - 57 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hepatotoxic

Species or TestSystem (Pharmacological Data)

ICR mouse

Sex

male

Route of Application

intraperitoneal

Kind of Dosing (Pharmacological Data)

pretreatment 2 mg/kg, i.p. methamphetamine in 10 ml/kg saline; administr. - 0.005 ml/kg, i.p. CCl4 with 5, 10, 15 mg/kg, i.p. methamphetamine; control i.p. injection 10 ml/kg saline

Exposure Period (Pharmacological Data)

24 h

Method (Pharmacological Data)

adult ICR mice; 8-10 male, 30-35 g; pretreat. methamphetamine 2 mg/kg at 7-day intervals for 5 weeks; after 1 week administr. CCl4 (0.005 ml/kg) with or without methamphetamine (5, 10, 15 mg/kg); killed; blood collected

Further Details (Pharmacological Data)

hepatic necrosis assessed through serum ALT (alanine aminotransferase) activity; ALT activ. measured 24 h after CCl4 dose according to Bergmeyer; control pretreatment saline; compared with control

Results

subchronic methamphetamine pretreatment signif. increased potentiation of CCl4 hepatotoxicity by all tested doses of methamphetamine; ratio ALT activ. for methamphetamine/saline pretreated mice was ca. 8, 18, 28 at 5, 10, 15 mg/kg methamphetamine, resp.

Reference

Roberts, Stephen M.; Harbison, Raymond D.; James, Robert C.

Toxicology, 1995 , vol. 97, # 1-3 p. 49 - 57 Title/Abstract Full Text View citing articles Show Details

mixture (composition partially given) :

tetrachloromethane (R)-(-)-methamphetamine Hide Details

Chemical Name: gadolinium chloride; carbon tetrachloride; methamphetamine; mixture of Reaxys Registry Number: 8188773 Type of Substance: mixture (composition partially given)

Chemical Names and Synonyms gadolinium chloride; carbon tetrachloride; methamphetamine; mixture of Composition tetrachloromethane

(R)-(-)-methamphetamine

no reactions.

Bioactivity (3)

1

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Bioactivity Pharmacological Data (3) 1 of 3

2 of 3

3 of 3

Comment (Pharmacological Data)

Bioactivities present

Reference

Roberts, Stephen M.; Harbison, Raymond D.; James, Robert C.

Toxicology, 1995 , vol. 97, # 1-3 p. 49 - 57 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hepatotoxic

Endpoint of Effect (Pharmacological Data)

ALT activity

Species or TestSystem (Pharmacological Data)

ICR mouse

Sex

male

Route of Application

intraperitoneal

Kind of Dosing (Pharmacological Data)

gadolinium chloride 10 mg/kg, i.v. in 10 ml/kg saline; CCl4 0.005 ml/kg i.p.; methamphetamine 15 mg/kg, i.p. in 10 ml/kg saline; control i.p. injection 10 ml/kg saline

Exposure Period (Pharmacological Data)

24 h

Method (Pharmacological Data)

adult ICR mice; 10 male, 30-35 g; pretreated gadolinium chloride; administr. CCl4 (0.005 ml/kg) with or without methamphetamine (15 mg/kg); killed; blood collected; necrogenic effect of title comp. assess. by serum alanine aminotransferase (ALT) activ.

Further Details (Pharmacological Data)

ALT activ. measured 24 h after CCl4 dose according to Bergmeyer; compared with control

Results

pretreatment with gadolinium chlorid did not affect minimal toxicity of CCl4 alone and ALT activ.; substantially diminished the potentiation of CCl4 hepatotoxicity by methamphetamine; presented as graph

Reference

Roberts, Stephen M.; Harbison, Raymond D.; James, Robert C.

Toxicology, 1995 , vol. 97, # 1-3 p. 49 - 57 Title/Abstract Full Text View citing articles Show Details

Effect (Pharmacological Data)

hepatotoxic

Species or TestSystem (Pharmacological Data)

ICR mouse

Sex

male

Route of Application

intraperitoneal

Kind of Dosing (Pharmacological Data)

gadolinium chloride 10 mg/kg, i.v. in 10 ml/kg saline; CCl4 0.005 ml/kg i.p.; methamphetamine 15 mg/kg, i.p. in 10 ml/kg saline; control i.p. injection 10 ml/kg saline

Exposure Period (Pharmacological Data)

24 h

Method (Pharmacological Data)

adult ICR mice; 10 male, 30-35 g; pretreated gadolinium chloride; administr. CCl4 (0.005 ml/kg) with or without methamphetamine (15 mg/kg); killed; liver removed; sections 4-6 μm thick; stained with hematoxylin and eosin

Further Details (Pharmacological

examined histopathology by light microscopy

Data)

149

Results

pretreatment with gadolinium chloride CCl4-induced necrotic lesions were typically 1/3 to 1/2 the size of those in mice without gadolinium pretriatment; present necrotic foci; many of the lobules had normal, or nearly normal, histology

Reference

Roberts, Stephen M.; Harbison, Raymond D.; James, Robert C.

Toxicology, 1995 , vol. 97, # 1-3 p. 49 - 57 Title/Abstract Full Text View citing articles Show Details

mixture (composition partially given) :

(R)-(-)-methamphetamine carbidopa, catechol-O-methyl transferase (COMT) inhibitor, levodopa; mixture of

Reaxys Registry Number: 11400535 Type of Substance: mixture (composition partially given)

no reactions.

Bioactivity (2)

1

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Composition (R)-(-)-methamphetamine

carbidopa, catechol-O-methyl transferase (COMT) inhibitor, levodopa; mixture of

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Bioactivity Pharmacological Data (2) 1 of 2

Comment (Pharmacological Data)

Bioactivities present

Reference

Caron, Marc G.; Sotnikova, Tatyana D.; Gainetdinov, Raul R.

Patent: US2007/27208 A1, 2007 ; Title/Abstract Full Text Show Details

2 of 2

Effect (Pharmacological Data)

locomotor activity

Species or TestSystem (Pharmacological Data)

DAT-KO mouse

Sex

male and female

Route of Application

intraperitoneal

Method (Pharmacological Data)

Experimental We report here that the pharmacologic inhibition of the rate-limiting enzyme of DA synthesis, TH, almost immediately depletes brain DA to undetectable levels in DAT-KO mice and induces a transient recapitulation of essentially all PD symptoms for up to 16 h. DA-deficient DAT-KO mice (DDD mice) thus represent an acute PD model that is useful for studying the efficacy of compounds that potentially can restore control of locomotion in the absence of any contribution of the dopaminergic system. By using this approach, we found that several amphetamine derivatives can counteract the behavioral manifestations of severe DA deficiency, suggesting that, in addition to well-known DA-mediated effects, amphetamine-like compounds can also affect motor functions in a DA- and DAT-independent manner. Materials and Methods Animals. DAT-KO mice were generated as previously described [11].

Animal care was in accordance with the Guide for Care and Use of Laboratory Animals (National Institutes of Health publication No.865-23, Bethesda, Md., United States) with an approved protocol from the Duke University Institutional Animal Care and Use Committee. C57BL/6J3129Sv/J hybrid WT and DAT-KO mice, 3-5 mo old, of both sexes were used. None of animals used in these studies had the neurodegenerative phenotype sporadically observed in DAT-KO mice [60]. Drugs. Drugs or saline (0.9percent NaCl) were administered intraperitoneally (IP) or subcutaneously (SC) in a volume of 10 ml/kg. The drags were either from Sigma (St. Louis, Mo., United States) or supplied by the National Institute of Drug Abuse (NIDA). Drugs provided by the NIDA Drug Supply Program included: (+/-)-MDMA, (+)-MDMA, (+/-)-6-OH-MDA, (+/-)-MDA, (+/-)-MDE, (+)-MDE, (-)-MDE, and AFT (alpha-ethyl-tryptamine acetate).

Neurochemical assessments. Striatal tissue contents of DA and frontal cortical tissue levels of NE were assessed using HPLC-EC (high performance liquid

chromatography with electrochemical detection) as described [8]. In vivo microdialysis measurements of striatal extracellular DA levels in freely moving mice were performed at least 24 h after implantation of a microdialysis probe as described previously [50]. Dialysate samples were assayed for DA using HPLC-EC. Behavioral methods. Locomotor activity of littermate WT and DATKO mice was measured in an Omnitech CCDigiscan (Accuscan Instruments, Columbus, Ohio United States) activity monitor under bright illumination [83]. All behavioral experiments were performed between 10:00 AM and 5:00 PM. Activity was measured at 5-min intervals, To evaluate the effects of drugs on motor behaviors, mice were placed into activity monitor chambers (20.x.20 cm) for 30 min and then treated with αMT (250 mg/kg IP). A drug or combination of drugs were injected 1 h after αMT administration, and various parameters of locomotor activity were monitored for up to 3 h. In cumulative dosing experiments, animals were treated with increasing doses of drugs after a 1-h interval. For the akinesia test, the mouse is held by the tail so that it is standing on forelimbs only and moving on its own. The number of steps taken with both forelimbs was recorded during a 30-s trial [57]. The presence of catalepsy was determined and measured by placing the animal's forepaws on a horizontal wooden bar (0.7 cm in diameter), 4 cm above the tabletop. The time until the mouse removed both forepaws from the bar was recorded, with a maximum cut-off time of 3 min [53]. In the grasping test of muscular rigidity, the mouse is suspended by its forelimbs on a metal rod (diameter: 0.25 cm) positioned approximately 20 cm above the table. The time the animal remains on the rod (maximum 1 min) was noted [58]. To assess rigidity in a bracing task, the number of steps taken with each forelimb when the mouse is pushed sideways over a distance of 50 cm was recorded [57]. Tremor was scored visually in mice using the rating scale [54]: 0, no tremor; 1, occasional isolated twi Results

potent synergistic effect of L-DOPA/carbidopa and METH was observed; figure is given

Location

Page/Page column 3-4; 12-15; sheet 10

Reference

Caron, Marc G.; Sotnikova, Tatyana D.; Gainetdinov, Raul R.

Patent: US2007/27208 A1, 2007 ; Title/Abstract Full Text Show Details

150

Reaxys Registry Number: 26574692 Type of Substance: mixture (composition completely given)

mixture (composition completely given) :

d-N,a-dimethylphenethylamine 1,3-di-o-tolyl-guanidine

no reactions.

Bioactivity (2)

1

Bioactivity (1)

1

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Composition d-N,a-dimethylphenethylamine (0.0001 - 10 μmol)

1,3-di-o-tolyl-guanidine (0.01 - 1000 μmol)

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Bioactivity Pharmacological Data (2) 1 of 2

2 of 2

151

Comment (Pharmacological Data)

Bioactivities present

Reference

Kaushal, Nidhi; Robson, Matthew J.; Rosen, Abagail; McCurdy, Christopher R.; Matsumoto, Rae R.

European Journal of Pharmacology, 2014 , vol. 724, # 1 p. 193 - 203 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Kaushal, Nidhi; Robson, Matthew J.; Rosen, Abagail; McCurdy, Christopher R.; Matsumoto, Rae R.

European Journal of Pharmacology, 2014 , vol. 724, # 1 p. 193 - 203 Title/Abstract Full Text View citing articles Show Details

mixture (composition partially given) :

2-[(diphenylmethyl)sulfinyl]acetamide d-N,a-dimethylphenethylamine

Reaxys Registry Number: 27703154 Type of Substance: mixture (composition partially given)

no reactions.

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Composition d-N,a-dimethylphenethylamine

2-[(diphenylmethyl)sulfinyl]acetamide

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Bioactivity Pharmacological Data (1) 1 of 1

152

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Gonzlez, Betina; Raineri, Mariana; Cadet, Jean Lud; Garca-Rill, Edgar; Urbano, Francisco J.; Bisagno, Veronica

Neuropharmacology, 2014 , vol. 87, p. 188 - 197 Title/Abstract Full Text View citing articles Show Details

mixture (composition partially given) :

6-D(−)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-αphenylacetamidopenicillinic acid 2-diethylaminoethyl ester hydrochloride 2-diethylaminoethyl 2-[(2,6-dichlorophenyl)amino]benzeneacetate hydrochloride (RS)-N-[1-(1-benzothien-2-yl)ethyl]-N-(2-diethylaminoacetyloxy)urea hydrochloride metaproterenol triacetate hydrochloride (R)-(-)-methamphetamine

Reaxys Registry Number: 27922949 Type of Substance: mixture (composition partially given)

no reactions.

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Composition (R)-(-)-methamphetamine

2-diethylaminoethyl 2-[(2,6dichlorophenyl)amino]benzeneacetate hydrochloride

6-D(−)-α-(4-ethyl-2,3-dioxo-1piperazinylcarbonylamino)-αphenylacetamidopenicillinic acid 2diethylaminoethyl ester hydrochloride

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Identification Bioactivity (1) Other Data (15)

1

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metaproterenol triacetate hydrochloride

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Identification Substance Label (1) Label

Reference

3; 4; 5

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

Bioactivity Pharmacological Data (1) 1 of 1

Location

Paragraph

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

Other Data Use (15) Use Pattern

Location

Reference

Pharmaceuticals

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

allergic conjunctivitis

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

allergic rhinitis

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

asthma

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

chronic bronchitis

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

chronic obstructive pulmonary disease

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

cystic fibrosis

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

emphysema

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

itchiness

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

lower, and upper respiratory tract infections

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

pneumonia

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

pulmonary condition

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

pulmonary fibrosis

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

runny nose

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

sarcoidosis

Page/Page column 75-78

YU, Chongxi; XU, Lina

Patent: US2015/72961 A1, 2015 ; Title/Abstract Full Text Show Details

Chemical Name: (S)-N-methylamphetamine hydrochloride Reaxys Registry Number: 28371209

Molecular Formula: C10H15N*(x)ClH Linear Structure Formula: C10H15N*xClH InChI Key: TWXDDNPPQUTEOV-FVGYRXGTSA-N

153

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no reactions.

Identification Physical Data (1)

1

(S)-N-methylamphetamine hydrochloride Identification Patent-Specific Data (1) Location in Patent

Reference

Page/Page column

CHEMAPOTHECA, LLC; Meckler, Harold; Gregg, Brian Thomas; Yang, Jie

Patent: US2015/183716 A1, 2015 ; Title/Abstract Full Text Show Details

Physical Data Melting Point (1) Melting Point

Location

Reference

172 - 175 °C

Paragraph 0159

CHEMAPOTHECA, LLC; Meckler, Harold; Gregg, Brian Thomas; Yang, Jie

Patent: US2015/183716 A1, 2015 ; Title/Abstract Full Text Show Details

154

Reaxys Registry Number: 28633412 Type of Substance: mixture (composition partially given)

mixture (composition partially given) :

methamphetamin chlordiazepoxide

no reactions.

Bioactivity (1)

1

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Show Related Substances

Composition methamphetamin

chlordiazepoxide

155

mixture (composition partially given) :

Methamphetamin thalidomide

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Reaxys Registry Number: 28681688 Type of Substance: mixture (composition partially given)

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Composition thalidomide

Methamphetamin

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Bioactivity Pharmacological Data (1) 1 of 1

156

Comment (Pharmacological Data)

Bioactivities present

Reference

Astarita, Giuseppe; Avanesian, Agnesa; Grimaldi, Benedetto; Realini, Natalia; Justinova, Zuzana; Panlilio, Leight V.; Basit, Abdul; Goldberg, Steven R.; Piomelli, Daniele

PLoS ONE, 2015 , vol. 10, # 2 art. no. E0116961 Title/Abstract Full Text View citing articles Show Details

Reaxys Registry Number: 28681689 Type of Substance: mixture (composition partially given)

mixture (composition partially given) :

Methamphetamin L-cycloserine

no reactions.

Bioactivity (1)

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Composition L-cycloserine

Methamphetamin

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Bioactivity Pharmacological Data (1) 1 of 1

Comment (Pharmacological Data)

Bioactivities present

Reference

Astarita, Giuseppe; Avanesian, Agnesa; Grimaldi, Benedetto; Realini, Natalia; Justinova, Zuzana; Panlilio, Leight V.; Basit, Abdul; Goldberg, Steven R.; Piomelli, Daniele

PLoS ONE, 2015 , vol. 10, # 2 art. no. E0116961 Title/Abstract Full Text View citing articles Show Details

1

157

Reaxys Registry Number: 29397809 Type of Substance: mixture (composition partially given)

mixture (composition partially given) :

S-methamphetamine hydrochloride 3'-azido-2',3'-deoxythymidine Nevirapine Saquinavir

no reactions.

Bioactivity (2)

1

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Composition 3'-azido-2',3'-deoxythymidine

Nevirapine

S-methamphetamine hydrochloride

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Saquinavir

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Bioactivity Pharmacological Data (2) 1 of 2

2 of 2

Comment (Pharmacological Data)

Bioactivities present

Reference

Sanchez, Ana B.; Varano, Giuseppe P.; De Rozieres, Cyrus M.; Maung, Ricky; Catalan, Irene C.; Dowling, Cari C.; Sejbuk, Natalia E.; Hoefer, Melanie M.; Kaul, Marcus

Antimicrobial Agents and Chemotherapy, 2016 , vol. 60, # 1 p. 168 - 179 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Sanchez, Ana B.; Varano, Giuseppe P.; De Rozieres, Cyrus M.; Maung, Ricky; Catalan, Irene C.; Dowling, Cari C.; Sejbuk, Natalia E.; Hoefer, Melanie M.; Kaul, Marcus

Antimicrobial Agents and Chemotherapy, 2016 , vol. 60, # 1 p. 168 - 179 Title/Abstract Full Text View citing articles Show Details

158

Reaxys Registry Number: 29397810 Type of Substance: mixture (composition partially given)

mixture (composition partially given) :

S-methamphetamine hydrochloride 3'-azido-2',3'-deoxythymidine

no reactions.

Bioactivity (2)

1

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Composition S-methamphetamine hydrochloride

3'-azido-2',3'-deoxythymidine

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2 of 2

159

Comment (Pharmacological Data)

Bioactivities present

Reference

Sanchez, Ana B.; Varano, Giuseppe P.; De Rozieres, Cyrus M.; Maung, Ricky; Catalan, Irene C.; Dowling, Cari C.; Sejbuk, Natalia E.; Hoefer, Melanie M.; Kaul, Marcus

Antimicrobial Agents and Chemotherapy, 2016 , vol. 60, # 1 p. 168 - 179 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Sanchez, Ana B.; Varano, Giuseppe P.; De Rozieres, Cyrus M.; Maung, Ricky; Catalan, Irene C.; Dowling, Cari C.; Sejbuk, Natalia E.; Hoefer, Melanie M.; Kaul, Marcus

Antimicrobial Agents and Chemotherapy, 2016 , vol. 60, # 1 p. 168 - 179 Title/Abstract Full Text View citing articles Show Details

mixture (composition partially given) :

Nevirapine S-methamphetamine hydrochloride

Reaxys Registry Number: 29397811 Type of Substance: mixture (composition partially given)

no reactions.

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Composition Nevirapine

S-methamphetamine hydrochloride

Bioactivity (2)

1

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Bioactivity Pharmacological Data (2) 1 of 2

2 of 2

160

Comment (Pharmacological Data)

Bioactivities present

Reference

Sanchez, Ana B.; Varano, Giuseppe P.; De Rozieres, Cyrus M.; Maung, Ricky; Catalan, Irene C.; Dowling, Cari C.; Sejbuk, Natalia E.; Hoefer, Melanie M.; Kaul, Marcus

Antimicrobial Agents and Chemotherapy, 2016 , vol. 60, # 1 p. 168 - 179 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Sanchez, Ana B.; Varano, Giuseppe P.; De Rozieres, Cyrus M.; Maung, Ricky; Catalan, Irene C.; Dowling, Cari C.; Sejbuk, Natalia E.; Hoefer, Melanie M.; Kaul, Marcus

Antimicrobial Agents and Chemotherapy, 2016 , vol. 60, # 1 p. 168 - 179 Title/Abstract Full Text View citing articles Show Details

Reaxys Registry Number: 29397812 Type of Substance: mixture (composition partially given)

mixture (composition partially given) :

Saquinavir S-methamphetamine hydrochloride

no reactions.

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Composition S-methamphetamine hydrochloride

Bioactivity

Saquinavir

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Bioactivity (2)

1

Pharmacological Data (2) 1 of 2

2 of 2

161

Comment (Pharmacological Data)

Bioactivities present

Reference

Sanchez, Ana B.; Varano, Giuseppe P.; De Rozieres, Cyrus M.; Maung, Ricky; Catalan, Irene C.; Dowling, Cari C.; Sejbuk, Natalia E.; Hoefer, Melanie M.; Kaul, Marcus

Antimicrobial Agents and Chemotherapy, 2016 , vol. 60, # 1 p. 168 - 179 Title/Abstract Full Text View citing articles Show Details

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

Sanchez, Ana B.; Varano, Giuseppe P.; De Rozieres, Cyrus M.; Maung, Ricky; Catalan, Irene C.; Dowling, Cari C.; Sejbuk, Natalia E.; Hoefer, Melanie M.; Kaul, Marcus

Antimicrobial Agents and Chemotherapy, 2016 , vol. 60, # 1 p. 168 - 179 Title/Abstract Full Text View citing articles Show Details

Reaxys Registry Number: 29479297 Type of Substance: mixture (composition partially given)

mixture (composition partially given) :

S-methamphetamine hydrochloride human immunodeficiency virus type 1 BaL gp120

no reactions.

Bioactivity (1)

1

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Composition S-methamphetamine hydrochloride

human immunodeficiency virus type 1 BaL gp120

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Bioactivity Pharmacological Data (1) 1 of 1

162

Comment (Pharmacological Data)

Bioactivities present

Reference

Sanchez, Ana B.; Varano, Giuseppe P.; De Rozieres, Cyrus M.; Maung, Ricky; Catalan, Irene C.; Dowling, Cari C.; Sejbuk, Natalia E.; Hoefer, Melanie M.; Kaul, Marcus

Antimicrobial Agents and Chemotherapy, 2016 , vol. 60, # 1 p. 168 - 179 Title/Abstract Full Text View citing articles Show Details

mixture (composition partially given) :

low-affinity anti-(+)-methamphetamine monoclonal antibody 6H8 Methamphetamin

Reaxys Registry Number: 29480448 Type of Substance: mixture (composition partially given)

no reactions.

Bioactivity (1)

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Composition Methamphetamin

low-affinity anti-(+)-methamphetamine monoclonal antibody 6H8

1

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Bioactivity Pharmacological Data (1) 1 of 1

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

The Board of Trustees of the University of Arkansas; Owens, Samuel M.; Carroll, Frank Ivy; Abraham, Philip

Patent: US9303092 B2, 2016 ; Title/Abstract Full Text Show Details

163

mixture (composition partially given) :

high-affinity anti-(+)-methamphetamine monoclonal antibody 6H4 Methamphetamin

Reaxys Registry Number: 29480450 Type of Substance: mixture (composition partially given)

no reactions.

Bioactivity (1)

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Composition Methamphetamin

high-affinity anti-(+)-methamphetamine monoclonal antibody 6H4

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Bioactivity Pharmacological Data (1) 1 of 1

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

The Board of Trustees of the University of Arkansas; Owens, Samuel M.; Carroll, Frank Ivy; Abraham, Philip

Patent: US9303092 B2, 2016 ;

1

Title/Abstract Full Text Show Details

164

Reaxys Registry Number: 29480452 Type of Substance: mixture (composition partially given)

mixture (composition partially given) :

anti-phencyclidine monoclonal antibody Fab fragment Methamphetamin

no reactions.

Bioactivity (1)

1

Bioactivity (1)

1

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Composition anti-phencyclidine monoclonal antibody Fab fragment

Methamphetamin

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Bioactivity Pharmacological Data (1) 1 of 1

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

The Board of Trustees of the University of Arkansas; Owens, Samuel M.; Carroll, Frank Ivy; Abraham, Philip

Patent: US9303092 B2, 2016 ; Title/Abstract Full Text Show Details

165

mixture (composition partially given) :

anti-d-methamphetamine-specific monoclonal antibody Fab fragment Methamphetamin

Reaxys Registry Number: 29480453 Type of Substance: mixture (composition partially given)

no reactions.

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Composition Methamphetamin

anti-d-methamphetamine-specific monoclonal antibody Fab fragment

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Bioactivity Pharmacological Data (1) 1 of 1

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

The Board of Trustees of the University of Arkansas; Owens, Samuel M.; Carroll, Frank Ivy; Abraham, Philip

Patent: US9303092 B2, 2016 ; Title/Abstract Full Text Show Details

166

mixture (composition partially given) :

high-affinity anti-(+)-methamphetamine, (+)-amphetamine, (+)-3,4methylenedioxymethamphetamine monoclonal antibody 4G9 Methamphetamin

Reaxys Registry Number: 29480455 Type of Substance: mixture (composition partially given)

no reactions.

Bioactivity (1)

1

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Composition high-affinity anti-(+)-methamphetamine, (+)-amphetamine, (+)-3,4-methylenedioxymethamphetamine monoclonal antibody 4G9

Methamphetamin

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Bioactivity Pharmacological Data (1) 1 of 1

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

The Board of Trustees of the University of Arkansas; Owens, Samuel M.; Carroll, Frank Ivy; Abraham, Philip

Patent: US9303092 B2, 2016 ; Title/Abstract Full Text Show Details

167

mixture (composition partially given) :

anti-(+)-methamphetamine monoclonal antibody mAb6H7 Methamphetamin

Reaxys Registry Number: 29480456 Type of Substance: mixture (composition partially given)

no reactions.

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Composition Methamphetamin

anti-(+)-methamphetamine monoclonal antibody mAb6H7

Bioactivity (1)

1

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Bioactivity Pharmacological Data (1) 1 of 1

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

The Board of Trustees of the University of Arkansas; Owens, Samuel M.; Carroll, Frank Ivy; Abraham, Philip

Patent: US9303092 B2, 2016 ; Title/Abstract Full Text Show Details

168

Reaxys Registry Number: 29480457 Type of Substance: mixture (composition partially given)

mixture (composition partially given) :

anti-(+)-methamphetamine monoclonal antibody mAb9B11 Methamphetamin

no reactions.

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Composition Methamphetamin

anti-(+)-methamphetamine monoclonal antibody mAb9B11

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Bioactivity Pharmacological Data (1) 1 of 1

Comment (Pharmacological Data)

physiological behaviour discussed

Reference

The Board of Trustees of the University of Arkansas; Owens, Samuel M.; Carroll, Frank Ivy; Abraham, Philip

Patent: US9303092 B2, 2016 ;

Bioactivity (1)

1

Title/Abstract Full Text Show Details