1-(1-(4-Methoxyphenyl)cyclohexyl)piperidine (4-MeO-PCP) [C18H27NO]

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5 reactions in Reaxys

2018-03-25 13h:29m:07s (EST)

O

1. Query

N

Search as: As drawn

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2018-03-25 13:41:19

H N

O N

Rx-ID: 30499111 View in Reaxys 1/5 Yield

Conditions & References Reaction Steps: 2 1: toluene / 12 h / 130 °C 2: tetrahydrofuran / -78 - 20 °C in tetrahydrofuran, toluene Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco; Bioorganic and Medicinal Chemistry Letters; vol. 21; nb. 7; (2011); p. 2059 - 2063 View in Reaxys

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Br Mg

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Rx-ID: 30499147 View in Reaxys 2/5 Yield

Conditions & References in tetrahydrofuran, T= -78 - 20 °C Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco; Bioorganic and Medicinal Chemistry Letters; vol. 21; nb. 7; (2011); p. 2059 - 2063 View in Reaxys

O O N

Rx-ID: 30499204 View in Reaxys 3/5 Yield

Conditions & References Reaction Steps: 2 1: toluene / 12 h / 130 °C 2: tetrahydrofuran / -78 - 20 °C in tetrahydrofuran, toluene Zarantonello, Paola; Bettini, Ezio; Paio, Alfredo; Simoncelli, Chiara; Terreni, Silvia; Cardullo, Francesco; Bioorganic and Medicinal Chemistry Letters; vol. 21; nb. 7; (2011); p. 2059 - 2063 View in Reaxys

HO N

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O

N

N

Rx-ID: 1462237 View in Reaxys 4/5 Yield

Conditions & References in diethyl ether, ethanol, Time= 0.5h, Ambient temperature Masumoto; Takeuchi; Ohta; Hirobe; Chemical and Pharmaceutical Bulletin; vol. 37; nb. 7; (1989); p. 1788 - 1794 View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2018-03-25 13:41:19

O N

Rx-ID: 6429867 View in Reaxys 5/5 Yield

Conditions & References Cyclohexanoncyanhydrin, Piperidin, p-Methoxyphenylmagnesiumbromid Geneste et al.; European Journal of Medicinal Chemistry; vol. 14; (1979); p. 301,302 View in Reaxys 1-Piperidino-cyclohexan-carbonsaeure-nitril, 4-Methoxy-phenylmagnesiumbromid MADDOX; GODEFROI; PARCELL; Journal of medicinal chemistry; vol. 8; (1965); p. 230 - 235 View in Reaxys lt. Lit.6 Kalir et al.; European Journal of Medicinal Chemistry; vol. 13; (1978); p. 17,18 View in Reaxys

Copyright © 2018 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2018-03-25 13:41:19