Covid Reference

Page 99

Transmission

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unravel the secrets of super-spreading;

advance our understanding of host factors involved in the successful “seeding” of SARS-CoV-2 infection;

elucidate the role of young adults in the genesis of the second European SARS-CoV-2 wave;

continue to describe the conditions under which people should be allowed to gather in larger groups.

SARS-CoV-2 vaccines will have to be rolled out safely and affordably to billions of people. In the meantime there will be no return to a “normal” pre2020 way of life, and the best prevention scheme is a potpourri of physical distancing (Kissler 2020), intensive testing, case isolation, contact tracing, quarantine (Ferretti 2020) and as a last (but not impossible) resort, local lockdowns and curfews. If thanks to the history-making ultra-fast development of potent vaccines the pandemic should be over earlier than most people feared, SARS-CoV-2 will have taught the world a lesson of value for future pandemics: face masks are a simple and powerful tool to mitigate the impact of infectious respiratory diseases.

References Abbas M, Pittet D. Surfing the COVID-19 scientific wave. Lancet Infect Dis. 2020 Jun 30:S14733099(20)30558-2. PubMed: https://pubmed.gov/32619434. Full-text: https://doi.org/10.1016/S1473-3099(20)30558-2 Aboubakr HA, Sharafeldin TA, Goyal SM. Stability of SARS-CoV-2 and other coronaviruses in the environment and on common touch surfaces and the influence of climatic conditions: a review. Transbound Emerg Dis. 2020 Jun 30. PubMed: https://pubmed.gov/32603505. Full-text: https://doi.org/10.1111/tbed.13707 Adam DC, Wu P, Wong JY, et al. Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong. Nat Med. 2020 Nov;26(11):1714-1719. PubMed: https://pubmed.gov/32943787. Full-text: https://doi.org/10.1038/s41591-020-1092-0 Adam DC, Wu P, Wong JY, et al. Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong. Nat Med. 2020 Sep 17. PubMed: https://pubmed.gov/32943787. Fulltext: https://doi.org/10.1038/s41591-020-1092-0 Anderson EL, Turnham P, Griffin JR, Clarke CC. Consideration of the Aerosol Transmission for COVID-19 and Public Health. Risk Anal. 2020 May;40(5):902-907. PubMed: https://pubmed.gov/32356927. Full-text: https://doi.org/10.1111/risa.13500 Anfinrud P, Stadnytskyi V, Bax CE, Bax A. Visualizing Speech-Generated Oral Fluid Droplets with Laser Light Scattering. N Engl J Med. 2020 Apr 15. PubMed: https://pubmed.gov/32294341. Full-text: https://doi.org/10.1056/NEJMc2007800 Arons MM, Hatfield KM, Reddy SC, et al. Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility. N Engl J Med. 2020 Apr 24. PubMed: https://pubmed.gov/32329971 . Full-text: https://doi.org/10.1056/NEJMoa2008457 Arwady MA, Bawo L, Hunter JC, et al. Evolution of ebola virus disease from exotic infection to global health priority, Liberia, mid-2014. Emerg Infect Dis. 2015 Apr;21(4):578-84. PubMed: https://pubmed.gov/25811176. Full-text: https://doi.org/10.3201/eid2104.141940

COVID Reference ENG 006.9


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References

1hr
pages 497-554

Management

10min
pages 491-496

Diagnosis and classification

11min
pages 484-490

Transplantation

4min
pages 472-473

Transmission

4min
pages 482-483

Pathophysiology and immunopathology

4min
pages 480-481

Natural course and risk factors for complications

2min
page 479

Epidemiology of COVID-19 in children

2min
page 478

Cancer

8min
pages 468-471

Immunosuppression (other than HIV

3min
pages 466-467

HIV infection

6min
pages 463-465

COPD and smoking

4min
pages 461-462

Hypertension and cardiovascular co-morbidities

14min
pages 452-458

Diabetes mellitus

4min
pages 459-460

References

6min
pages 447-451

Special situations in severe COVID-19

3min
pages 445-446

References

25min
pages 429-440

Spotlight: The situation in a German COVID-19 hospital

4min
pages 443-444

Outlook and Recommendations

1min
page 428

4. Immunomodulators

19min
pages 415-424

Other treatments for COVID-19 (with unknown or unproven mechanisms of action

5min
pages 425-427

3. Monoclonal Antibodies and Convalescent Plasma

13min
pages 408-414

2. Various antiviral agents

5min
pages 405-407

1. Inhibitors of the viral RNA synthesis

11min
pages 399-404

Monitoring, treatment options

3min
pages 391-392

Studies with objectifiable tests

3min
pages 389-390

Reactivations, reinfections

2min
page 366

Outcome

27min
pages 352-365

Clinical classification

1min
page 351

Laboratory findings

6min
pages 347-350

References

21min
pages 324-332

Asymptomatic cases

4min
pages 334-335

Radiology

6min
pages 321-323

Incubation period

1min
page 333

Symptoms

21min
pages 336-346

Diagnosis

36min
pages 303-320

References

55min
pages 277-302

Outlook

5min
pages 272-276

Single Vaccines

24min
pages 247-261

Coming vaccines

8min
pages 267-271

Special Topics

9min
pages 241-246

Approved Vaccines

2min
pages 223-224

References

21min
pages 211-222

Outlook

1min
page 210

Transmission

1min
page 187

Epidemiology

11min
pages 175-186

Summary – 13 February

1min
page 173

Genomic Structure and Variation

4min
pages 164-166

References

8min
pages 167-172

Origin and Evolution

4min
pages 158-159

Introduction

1min
page 174

History

4min
pages 154-155

References

20min
pages 136-152

Conclusion

1min
page 135

Introduction

31min
pages 117-133

Containment or mitigation of COVID-19?

1min
page 134

References

40min
pages 99-116

Outlook

1min
page 98

Prevention

3min
pages 96-97

End of Quarantine

1min
page 95

Transmission Event

26min
pages 82-94

References

31min
pages 54-68

Summary

1min
page 69

Routes of Transmission

16min
pages 73-81

Outlook

3min
pages 52-53

The 2020 Lockdowns

7min
pages 48-51

Person-to-person transmission

2min
page 72

Special Aspects of the Pandemic

15min
pages 38-46

The SARS-CoV-2 pandemic: Past and Future

2min
page 47
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