Dogs have been used as powerful weapons of war for at least the last 3,000 years. The ancient Egyptians, Greeks, Persians, Sarmatians, Britons, and Romans are all known to have used dogs in combat, or for scouts, sentries, trackers, or executioners.
Reference:
https://ancientoriginsmagazine.com/becerrillo-the-terrifying-war-dog-of-the-spanish-conquistadors