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A Natural-Herbal methionine

M

ethionine (abbreviated as Met or M) is an Îą-aminoacid with the

chemical formula HO2CCH(NH2)CH2CH2SCH3. This essential amino acid is classified as nonpolar. Together with cystein, methionine is one of two sulfur-containing proteinogenic amino acids. Its derivative Sadenosyl methionine (SAM) serves as a methyl donor. Methionine is an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithine, and other phospholipids. Improper conversion of methionine can lead to atherosclerosis.

Methionine is required for It assists in the breakdown of fats and thereby prevents the build-up of fat in the arteries, as well as assisting with the digestive system and removing heavy metals from the body since it can be converted to cysteine, which is a precursor to glutathione, which is of prime importance in detoxifying the liver.

The amino acid methionine is also a great antioxidant as the sulfur it supplies inactivates free radicals.

It is also one of the three amino acids needed by the body to manufacture creatine monohydrate, a compound essential for energy production and muscle building.

Deficiency of methionine Severe deficiency may manifest in dementia, while lesser deficiencies may be known by symptoms like fatty liver, slow growth, weakness, edema and skin lesions.

Methionine is required in the diet and thus is considered an essential amino acid.

Methionine helps in the biochemical breakdown of fats in the body; this action prevents the accumulation of fat in the liver.

The availability of methionine in the body may affect the biochemical synthesis of the amino acids cystein and taurine.

Methionine also aids in the rapid detoxification of harmful compounds such as lead and any other heavy metals which may cause toxic side effects due to their presence in the body.

Methionine also actively reduces the onset of muscular weakness.

Methionine is also believed to be beneficial for proper bone formation.

Methionine has a powerful antioxidant action against free radicals produced in the natural metabolic processes of the body.

The amino acid methionine is also an excellent source for the essential mineral sulfure, which quickly inactivates free radicals produced in the body.

The amino acid is also required during the synthesis of nucleic acids, collagen and different proteins found in almost every cell- it is a constituent of many enzymes and proteins found in different parts of the body.

Methionine is not synthesized in the body and is considered to be an essential amino acid.

It needs to be obtained in the diet from methionine rich food sources or via dietary supplements of methionine or protein rich complexes in easily available form.

Methionine is a lipotropic, or a chemical substance that helps the liver process fats (lipids). Other lipotropics include choline, inositol, and betaine (trimethylglycine), all of which help prevent the accumulation of fat in the liver and thus ensure normal liver function, which is essential for the elimination of toxins from the body. Methionine also supports liver function by regulating glutathione supplies..

Methionine is essential for the formation of healthy collagen used to form skin, feathers, and connective tissue, and helps reduce the level of inflammatory histamines in the body.

Methionine is an essential vitamin, which means it must be obtained through dietary sources..

A FATTY LIVER (POULTRY)

Higher level of methionine is required to meet with the increased tissue demands for fast growth and high production.

It helps optimize protein synthesis and improves the tone and pliability of the skin and strengthens feathers.

Methionine is essential for the absorption and transportation and bioavailability of some essential minerals in the body.

It also acts as a methyl donor and prevent excess fat buildup in the liver.

Methionine deficiency causes Slow growth in broilers, layer chicks and growers.

Poor feed conversion ratio, lowered egg production.

Liver damage.

Loss of muscle tone and fat.

Skin tone and feather loosening.

Immune depression.

Natural Methionine Nature has provided methionine to plants as dipeptides and oligopeptides along with its precursors and intermediates to facilitate optimum biosynthesis of methionine, as per birds needs.

Herbs also have enzymes required for conversion of methionine into S-Adenosyl Methionine (SAM) which is Active Methionine.

Herbal Methionine as researched based formulation contains bioactive natural methionine in free as well as conjugated dipeptide and oligopeptide forms.

Herbal Methionine contains the precursors and intermediates of methionine, folic acid.

Serine - Serine is an efficient contributor to methionine formation. Natural serine present in Herbal Methionine provides significant contribution to methionine production. Herbal Methionine contains all of these pre-requisites for methionine formation from serine.

Aspartic Acid – Like serine, natural aspartic acid present in Herbal Methionine is converted through homoserine into homocysteine and then methionine, thereby providing an useful source of methionine bio-synthesis.

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Folic Acid - Folic acid present in Herbal Methionine helps in one carbon transfer reactions and thus spares methionine for protein synthesis and methylation functions.

Recycler of Methionine – S-Adenosyl Methionine (SAM) obtained from methionine is used in the synthesis of creatine. The homocystine further gets reconverted into methionine with the help of phosphatidyl choline and folic acid present in Herbal Methionine, for sustained bioavailability and activity of methionine.

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Andrographis paniculata 350 gms.

Zea mays 250 gms.

Ocimum sanctum 300 gms.

Asparagus racemosus 100 gms.

drtajdararosol@yahoo.com

Causes of Poor Feathering The absence of feathers on birds can result from any of several causes and can be separated into two groups: 1) those birds that cannot grow feathers and 2) those birds that pull or break them off. Either situation can be reversed by correcting the problem's cause.

The most common reason that feathers do not develop is a deficiency of a critical protein constituent (amino acid) from the diet of the birds. The feathers of birds contain high levels of a subunit of proteins called "methionine." Methionine is one of only a few amino acids that contain sulfur, and sulfur is a major constituent of feathers. If bird diets are deficient in any single amino acid, it will most likely be methionine. An adequate level of methionine is required in the diet and a deficiency results in reduced growth and feather development. A methionine deficient bird will tend to eat feathers in an attempt to satisfy a craving for this amino acid. A bird may even pull them from its own body.

Few ingredients used in making poultry diets contain adequate amounts of methionine, so manufactured methionine must be added to the dietary mixture to ensure that the birds receive an adequate amount. All quality poultry feeds are designed to contain adequate methionine and prevent reduced body growth and feather development. However, if additional grains (such as corn) are fed with the complete feed, then the amount of methionine consumed by the bird can be inadequate for providing growth and feather development. Feeding of additional grains with complete poultry feeds is not recommended.

Pyruvate + SO4

NH3

ď Ą-Ketobutyrate

Propionyl CoA

5 Cysteine

Cystathionine

4 Cystathionase Cystathionine ď ˘-synthase (requires pyridoxal phosphate)

CH CH33 group adenosine donation

3

CH3 S-Adenosylmethionine

Homocysteine-SH CH33-B12

THF

1 Methionine adenosyltransferase ATP

2a

Methionine synthase

2b

CH3 3 Methionine-S-CH Hydroxy B12

Figure 4. Metabolism of methionine and cysteine. THF is tetrahydrofolate.

N5-CH CH3 THF

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In a study published in British Journal of Nutrition (1985), Linda Saunderson reported that l-methionine incorporates better into different tissues like breast, leg, skin and brain of broiler chicks as compared to dlmethionine.

Linda Saunderson also reported that lmethionine excretes significantly lesser (less than 5 times) as compared to dl-methionine, providing sustained bio-actibity

14C

incorporation (per min per gm tissue)

dl-methionine

l-methionine

Breast

2851

4249

Leg

2821

4169

Skin

2431

4540

Brain

1797

3468

14C

Excreta

in excreta extract 9.59

1.88

ADVANTAGES : Provides 100% Methionine to the animal/bird for optimum growth.

Controls fat metabolism hence prevents fatty liver syndrome Provides energy so that the animal/bird remain in healthy & lively state Keep the Liver in its vibrant state of performance hence there is production of optimum bile secretion and prevention from aflatoxicosis Methonine is helpful in optimum cell synthesis hence it provides basic building blocks for newer cells.

Optimizes hatchability

INDICATIONS : Improves skeletal & muscular growth Improves FCR & Anabolic effect Optimum production Enhanced Convalescence Healthy Digestion Early recovery from skin diseases and feather loss Recovers Leg Weakness DOSAGE FORM : Powder Oral PRESENTATION: 1 Kg Pack 20 Kg Pack

Effect of supplementing Herbal Methionine on performance and immune response of broilers Abstract A study was conducted with broilers to find out the effect of addition of herbal methionine (1 g/kg) to a basal diet containing crude protein, 223 g/kg, ME, 12¡25 MJ/kg, Supplemental levels of methionine was found to be highly effective in improving the growth, food consumption, food conversion ratio and immunity of broilers. A higher value for leucocyte migration inhibition was observed in chicks fed on the diet containing 1.5 g/kg methionine which indicated a significant improvement in cellular immune response. Hamagutination test and ELISA indicated enhanced antibody titres in chicks receiving 2.5 g/kg of herbal methionine, showing a significantly better humoral immune response.

Hence it is advocated to supplement Herbal Methionine for efficient FCR, growth and enhanced immunity of boilers.

Growth and Carcass Quality of Slow Growing Chicks on diets containing Different Levels of Herbal Methionine

The responses of slow growing chicks to different dietary levels of herbal methionine and its interaction were investigated during the startergrower period from 1 to 56 d of age. Therefore, a basal marginally herbal methionine deficient all-mash corn-soybean meal diet was formulated to contain 0.32% herbal methionine, 0.65% total sulphur amino acid (TSAA) and adequate level of choline (NRC, 1994). This diet was supplemented with 0, 0.05 and 0.10% of herbal methionine. Thus, there were nine experimental diets; each diet was fed to 40 chicks divided equally among 5 replicates of eight chicks each. Herbal Methionine level at 0.37 and 0.42% significantly improved BWG by 2.1 and 8.1% and FCR by 4.5 and 8.6% compared to the basal diet, respectively. Moreover, herbal methionine at 0.37 and 0.42% significantly decreased serum AST and ALT, and abdominal fat compared to the basal diet. There were significant interaction between methionine level. In conclusion, slow growing chicks (14.6 g/d) during 1-56 d of age could be fed diet containing 0.42% methionine.