Moderate
Severe
Severe, Potentially life-threatening
Diffuse macular, maculopapular, or morbilliform rash with vesicles or limited number of bullae, OR superficial ulcerations of mucous membrane limited to one site
Extensive or generalised bullous lesions OR Stevens-Johnson syndrome, OR ulceration of mucous membrane involving two or more distinct mucosal sites, OR Toxic Epidermal Necrolysis (TEN)
Severe
Severe, Potentially life-threatening Behaviour potentially harmful to self or others OR, life-threatening consequences
Allergic/dermatologic Cutaneous reaction rash
85
Parameter
Localised macular rash
Mild
Diffuse macular, maculopapular, or morbilliform rash, OR target lesions
Moderate
Neurologic Alteration in personality, Alteration causing no or behaviour or in mood minimal interference with usual social & functional activities
Alteration causing greater than minimal interference with usual social & functional activities
Alteration causing inability to perform usual social & functional activities AND intervention indicated
Altered Mental Status
Mild lethargy or somnolence causing greater than minimal interference with usual social & functional activities
Onset of confusion, Onset of delirium, memory impairment, obtundation, or coma lethargy, or somnolence causing inability to perform usual social & functional activities
Changes causing no or minimal interference with usual social & functional activities
Source: Adapted from Division of AIDS, National Institute of Allergy and Infectious Diseases, Table for grading the severity of adult and paediatric adverse events, Bethesda, Maryland, USA; December 2004. Notes: a. Values are provided for children in general except where age groups are specifically noted b. Usual social and functional activities in young children include those that are age and culturally appropriate (e.g. social interactions, play activities, learning tasks, etc) c. Activities that are age and culturally appropriate (e.g. feeding self with culturally appropriate eating implement, walking or using hands). ULN upper limit of normal
Guidelines for Antiretroviral Therapy of HIV infection in Infants and Children: Towards universal access
Mild
Annex G: Severity grading of selected clinical and laboratory toxicities most commonly seen with recommended antiretroviral drugs for children
Parameter