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Regenlite Transform Dr Donna Freeman, Director of Clinical Research at Chromogenex, discusses the benefits of the new Regenlite Transform laser in treating dermatological conditions Following the N-Lite and Regenlite, Chromogenex has now launched Regenlite Transform the only laser proven to stimulate the skin’s immune system by triggering an increase in Transforming Growth Factor Beta (TGFβ). Previously dermatological conditions such as psoriasis and eczema have been treated using the vascular mode of pulsed dye lasers. However, studies conducted with Regenlite and published in the British Journal of Dermatology indicated that the effect on acne was primarily due to biostimulation, in particular in the upregulating of TGFβ, which is involved in producing collagen and in downregulating the inflammatory cascade. (1) It is also known to be intimately involved in the acquisition of an immune response in the skin, to reduce the skin’s reactivity to triggers such as bacteria and viruses. The study showed that as early as three hours after treatment with Regenlite there was a massive upregulation in TGFβ of between 500 and 1500%. In our studies some patients reported a reduction in the pain of inflammatory acne and relief from itching in eczema and psoriasis within hours of their first treatment. With the new Regenlite we have focused on the parameters that are most effective for biostimulation, making it a major advance in the treatment of inflammatory skin conditions such as acne, psoriasis, rosacea, eczema and for warts and verrucas. These new parameters use much lower doses of light than in the vascular mode, and even better targeted parameters than the previous biostimulation Before
After
Psoriasis, Before and three months after eight treatments.
Before
After
Rosacea, Before and after three treatments.
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mode, making the treatments pain-free, very well tolerated, with no bruising or risk of hypopigmentation even in Fitzpatrick skin types V and VI. It is also the release of these molecules, in particular TGFβ, which produces the unique treatment results seen with this laser. TGFβ is known to be a potent
heat-damaged layer associated with ablative resurfacing techniques and initiates collagen stimulation without long-term impairment. The critical laser parameters engineered into the device to achieve bio-stimulation include pulse duration and temporal profile. The unique parameters ensure that erythrocytes remain intact, there is no endothelial cell Regenlite Transform introduces two unique modes necrosis and the of action, • Bio-stimulation, a multi-application mode formation of immature • Thermal for vascular treatments elastic fibres can be Delivering both double and triple pulse options, it uses low observed as soon fluency light to specifically target the microvasculature of as three days after the dermis and stimulate the tissue’s natural wound healing treatment(3). It uses response without any residual cell necrosis. Absorption of the a patented pulse yellow light into these blood vessels results in a mild thermal profile innovation effect and an inflammation that incites the release of cytokines of 100μs, which and growth factors and leads to the stimulation of new collagen. delivers consistent reproducible stimulus for neocollagenesis and a pivotal cutaneous immunological responses immunosuppressive cytokine. The action without tissue impairment. The pulse is of these is the promotion of inflammation generated by the ultra stable laser cavity, resolution within early acne lesions and which produces the fast rise pulse and pure prevention of microcomedone formation 585nm yellow light output. The absorption that occurs as a result of keratinocyte characteristics of oxyhemoglobin highlight hyperproliferation at the pilosebaceous unit. 585nm to be the perfect wavelength When the laser targets a small capillary; of light to combine maximum tissue 1) absorption in the oxyhemoglobin results penetration and maximum absorption. in heating of the capillary walls Wavelength stability is crucial to maximise 2) inflammatory mediators are released the absorption in oxyhaemoglobin and which stimulate fibroblast cells in the minimise unwanted purpura. Patients extracellular dermal matrix today are less likely to desire or tolerate 3) these fibroblasts produce new collagen. systemic treatments such as antibiotics or complicated and unpleasant ones as are Yellow laser light was originally used for traditional for psoriasis. I believe Regenlite the therapy of vascular lesions because Transform offers a more holistic treatment of their high absorption preference by that can improve patient safety, compliance oxyhaemoglobin. Following on from the and satisfaction. use of Argon (blue-green) laser light for REFERENCES the treatment of Port Wine Stains, attention 1. Seaton et al, British Journal of Dermatology focused on pulsed yellow dye lasers to 2006; 155: 748-755 replicate the highly selective damage to 2. Tan OT, Arch Dermatol 1986; 122(9): 1016-22 cutaneous micro-vessels but with minimal 3. Omi et al, Lasers in Surg Med 2003; 32: 46-49 injury to the overlying epidermis.(2) Dr Donna Freeman Careful consideration of the key parameters is director of clinical research and education of the laser can enable the focus of the at Chromogenex, treatment to not be the normal ectatic or with a focusing on dilated vessels of a vascular irregularity but clinical research, instead the smallest of the microvasculature development of within the dermis. Biochemical stimulation new devices and rather than thermolysis of these microtechnologies, construction of technical articles and documents. vessels mimics the effect of residual Aesthetics | February 2014