UNIMIB in Europe

UNIMIB IN EUROPE Participation of the University of Milano-Bicocca in the 2007-2013 framework programme for research and technological development

Foreword

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n this collection we report all the projects financed by the European Union in the 7th Framework Programme (2007-2013), in which the University of Milano-Bicocca is actively involved. In total 66 projects have been supported, covering all research areas of the University of Milano-Bicocca, from human sciences, sociology, economy, psychology and law, to the traditional hard sciences, chemistry, physics, biology, medicine, informatics, not to mention more interdisciplinary areas such as environmental sciences, materials science and biotechnology. The projects span from knowledge oriented basic and fundamental aspects, to highly applied topics and projects involving industries, stakeholders and technology transfer. These research activities resulted not only in excellent science, with international papers of high impact, but also in important applications and patents, with significant impact on issues related to society and industry.

The success of our researchers in the participation in the 7th Framework Programme demonstrates the existence of a lively community, with a high level of international connections and collaborations, and a strong propensity for research and innovation. These are essential elements for a modern University to successfully tackle the societal challenges and needs but also to provide a strong link between high-level educational programs with research activities done at the forefront of various disciplines. We will put a great deal of effort to continue and even improve in the new Horizon2020 EU research and innovation program.

Cristina Messa The Rector

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Index Foreword Alert Bio_sos Capmix Care Cascatbel Casi Catsense Cessda-ppp Cheetah Cisstem Cosmode Controlled systems Decore Eco Edonhist Encca Encite Endotofpet-us Etsf Eu-mascara Familyplatform Fusenet Geo Hem_id Holmes Image ddr Imode-ckd Impact Europe Impressions Lenvis

1 4 5 6 8 9 10 11 13 14 16 17 18 19 20 21 22 24 26 27 28 29 30 33 34 36 37 38 39 40 43

Meetmetonight Meusix Mime Nad Nemo Odmir Picosec-mcnet Pincette Prages Rastanews Safeguard Safeland Saferubber Sahwa Seatide Siera Sinergy Social polis Solar design Sos Swab Synapse Sysinbio Thinface Tolerage Unicellsys Workable Xd-string Yeastcell 3D Biomimetics

44 45 46 47 49 50 51 52 53 54 55 56 58 59 60 61 62 63 64 65 66 67 68 69 70 72 74 77 78 79

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ALERT

From 2008-02-01 to 2011-07-31

Early detection of adverse drug events by integrative mining of clinical records and biomedical knowledge

Objective Serious adverse effects resulting from the treatment with thalidomide prompted modern drug legislation more than 40 years ago. Post-marketing spontaneous reporting systems for suspected adverse drug reactions (ADRs) have been a cornerstone to detect safety signals in pharmacovigilance. It has become evident that adverse effects of drugs may be detected too late, when millions of persons have already been exposed.

In this project, an alternative approach for the detection of ADR signals will be developed. Rather than relying on the physician’s capability and willingness to recognize and report suspected ADRs, the system will systematically calculate the occurrence of disease (potentially ADRs) during specific drug use based on data available in electronic patient records. In this project, electronic health records (EHRs) of over 30 million patients from several European countries will be available. In an environment where rapid signal detection is feasible, rapid signal assessment is equally impor-

Project details

Project reference: 215847 Status: Completed Total cost: EUR 5 880 600 EU contribution: EUR 4 500 000 Programme acronym: FP7-ICT Subprogramme area: ICT-2007.5.2 Contract type: Collaborative project (generic)

Publications (20)via OpenAIRE

• Electronic healthcare databases for active drug safety surveillance: is there enough leverage?

Preciosa M. Coloma - Gianluca Trifiro - Martijn J. Schuemie Rosa Gini - Ron Herings - Julia Hippisley-Cox - Giampiero Mazzaglia Gino Picelli - Giovanni Corrao Lars Pedersen - Johan Lei - Miriam Sturkenboom • Using Electronic Health Care Records for Drug Safty Signal Detection A Comparative Evaluation of Statistical Methods Martijn J. Schuemie - Preciosa M. Coloma - Huub Straatman Ron M. C. Herings - Gianluca Trifiro - Justin Neil Matthews David Prieto-Merino - Mariam Molokhia - Lars Pedersen - Rosa Gini Francesco Innocenti - Giampiero Mazzaglia - Gino Picelli Lorenza Scotti - Johan van der Lei - Miriam C. J. M. Sturkenboom • Concept-based query expansion for retrieving gene related publications from MEDLINE Sergio Matos - Joel P. Arrais - Joao Maia-Rodrigues Jose Luis Oliveira

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Nederland

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tant. To rapidly assess signals, a number of resources will be used to substantiate the signals: causal reasoning based on information in the EHRs, semantic mining of the biomedical literature, and computational analysis of biological and chemical information (drugs, targets, anti-targets, SNPs, pathways, etc.).

The overall objective of this project is the design, development and validation of a computerized system that exploits data from electronic healthcare records and biomedical databases for the early detection of adverse drug reactions. The ALERT system will generate signals using data and text mining, epidemiological and other computational techniques, and subsequently substantiate these signals in the light of current knowledge of biological mechanisms and in silico prediction capabilities. The system should be able to detect signals better and faster than spontaneous reporting systems and should allow for identification of subpopulations at higher risk for ADRs.

Participants • FUNDACIO IMIM - España • LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE United Kingdom • UNIVERSITE VICTOR SEGALEN BORDEAUX II - France • UNIVERSIDADE DE AVEIRO - Portugal • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • UNIVERSITAT POMPEU FABRA - España • THE UNIVERSITY OF NOTTINGHAM - United Kingdom • UNIVERSIDADE DE SANTIAGO DE COMPOSTELA - España • ASTRAZENECA AB - Sverige • AGENZIA REGIONALE DI SANITÀ - Italia • AARHUS UNIVERSITETSHOSPITAL, AARHUS SYGEHUS - Danmark • IRCCS CENTRO NEUROLESI BONINO PULEJO - Italia • SOCIETÀ SERVIZI TELEMATICI SRL - Italia • PHARMO COOPERATIE UA - Nederland

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

BIO_SOS

From 2010-12-01 to 2013-11-30 • BIO SOS: www.biosos.eu

BIOdiversity Multi-Source Monitoring System: from Space TO Species

Objective BIO_SOS BIOdiversity multi-SOurce monitoring System: from Space TO Species is a response to the Call for proposals FP7- SPACE-2010-1, addressing topic SPACE.2010.1.1-04 BIO_SOS is a pilot project for effective and timely multi-annual monitoring of NATURA 2000 sites and their surrounding in support to management decisions in sample areas, mainly in Mediterranean regions and for the reporting on status and trends according

Project details

Project reference: 263435 Status: Completed Total cost: EUR 3 159 510 EU contribution: EUR 2 476 363 Programme acronym: FP7-SPACE Subprogramme area: SPA.2010.1.1-04 Contract type: Collaborative project (generic)

to National and EU obligations. The aim of BIO_SOS is two-fold: 1) the development and validation of a prototype multi-modular system to provide a reliable long term biodiversity monitoring service at high to very high-spatial resolution; 2) to embed monitoring information (changes) in innovative ecological (environmental) modelling for Natura 2000 site management. The system will be developed and validated within ecologically sensitive.

Participants • AGENZIA SPAZIALE ITALIANA - Italia • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • ALTAMIRA INFORMATION SL - España • PLANETEK ITALIA SRL - Italia • CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS - Hellas

Result in Brief

• Mapping habitat extension and loss over time

Report Summary

• Periodic Report Summary 1 - BIO_SOS (BIOdiversity MultiSource Monitoring System: from Space TO Species) • Periodic Report Summary 2 - BIO_SOS

Documents

• Periodic Report 1 - BIO_SOS

Coordinator CONSIGLIO NAZIONALE DELLE RICERCHE - Italia

• ICETA - INSTITUTO DE CIÊNCIAS E TECNOLOGIAS AGRÁRIAS E AGRO-ALIMENTARES - Portugal • ASHOKA TRUST FOR RESEARCH IN ECOLOGY AND THE ENVIRONMENT - India • STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK - Nederland • BARALDI CONSULTANCY IN REMOTE SENSING - Italia • ABERYSTWYTH UNIVERSITY - United Kingdom • UNIVERSITÀ DEGLI STUDI DI BARI “ALDO MORO” - Italia • PANEPISTIMIO IOANNINON - Hellas • UNIVERSITÉ PAUL SABATIER TOULOUSE III - France • PLANETEK HELLAS - Hellas • INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT - France

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CAPMIX

From 2010-10-01 to 2014-09-30 • CAPMIX: www.capmix.eu

Capacitive mixing as a novel principle for generation of clean renewable energy from salinity differences

Objective Electricity can be generated by mixing salt water and fresh water in a controlled way. Salt water can be sea water and fresh water can be river water, so this technology can be used wherever a river flows into the sea. CAPMIX stands for capacitive mixing and is a new way of harvesting this potential power. The principal advantage of this technology is that the electricity gen-

Project details

Project reference: 256868 Status: Execution Total cost: EUR 3 184 921 EU contribution: EUR 2 404 745 Programme acronym: CAPMIX Subprogramme area: ENERGY.2010.10.2-1 Contract type: Collaborative project (generic)

eration is directly linked to the mixing process, no additional intermediate conversions are necessary. There is thus no need for expensive complex converters like turbines or electrodes. This makes that this type of holds the greatest promise of becoming an economical and environmental benign renewable energy plant.

Participants • UNIVERSIDAD DE GRANADA - España • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • REDSTACK BV - Nederland • MAST CARBON INTERNATIONAL LTD - United Kingdom • POLITECHNIKA WROCLAWSKA - Polska

Result in Brief •

Salinity gradient provides green energy

Report Summary

• Periodic Report Summary - CAPMIX (Capacitive mixing as a novel principle for generation of clean renewable energy from salinity differences) • Periodic Report Summary 2 - CAPMIX

Coordinator

STICHTING WETSUS CENTRE OF EXCELLENCE FOR SUSTAINABLE WATER TECHNOLOGY Nederland

Publications (20)via OpenAIRE • A prototype cell for extracting energy from a water salinity difference by means of double layer expansion in nanoporous carbon electrodes D. Brogioli, R. Zhao, and P. M. Biesheuvel, Energy & Environmental Science, 4, 772-777 (2011).

• Ions Transport and Adsorption Mechanisms in Porous Electrodes During Capacitive-Mixing Double Layer Expansion (CDLE), R. A. Rica, D. Brogioli, R. Ziano, D. Salerno, and F. Mantegazza, J. Phys. Chem. C 116 32, 16934-16938 (2012) • Thermodynamic relation between voltage-concentration dependence and salt adsorption in electrochemical cells R. A. Rica, R. Ziano, D. Salerno, F. Mantegazza, and D. Brogioli, Phys.

Rev. Lett., accepted on 14 September 2012 • Electrochemical characterization of a supercapacitor flow cell for power production from salinity gradients B. B. Sales, F. Liu, O. Schaetzle, C. J. N. Buisman, H. V. M. Hamelers, Electrochimica Acta, 2012 10.1016/j.electacta.2012.05.069

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

• CAPMIX - Deploying Capacitors for Salt Gradient Power Extraction M. F. M. Bijmans, O. S. Burheim, M. Bryjak, A. Delgado, P. Hack, F. Mantegazza, S. Tenisson, H. V. M. Hamelers, Energy Procedia, 20, 2012, 108-115 • Effect of additional charging and current density on the performance of Capacitive energy extraction based on Donnan Potential F. Liu, O. Schaetzle, B. B. Sales, M. Saakes, C. J. N. Buisman, H. V. M. Hamelers, Energy & Environmental Science, 5, 2012, 8642-8650 • Faster Time Response by the Use of Wire Electrodes in Capacitive Salinity Gradient Energy Systems O. S. Burheim, F. Liu, B. B. Sales, O. Schaetzle, C. J. N. Buisman, H.V. M. Hamelers, The Journal of Physical Chemistry C, 116, 2012, 19203-19210 • Auto Generative Capacitive Mixing of Sea and River Water by the Use of Membranes O. Burheim, B.B. Sales, O. Schaezle, F. Liu, H. V. M. Hamelers, Paper no. IMECE2011-63459 pp. 483-492 • Impact of Wire Geometry in Energy Extraction from Salinity Differences Using Capacitive Technology B. B. Sales, O. S. Burheim, F. Liu, O. Schaetzle, C. J. N. Buisman, H. V. M. Hamelers, Environmental Science & Technology, 10.1021/ es302169c • Exploiting the spontaneous potential of the electrodes used incapacitive mixing technique for extraction of salinity-difference energy D. Brogioli, R. Ziano, R. A. Rica, and D. Salerno, Energy & environmental science, accepted on 21 september 2012 • Electro-diffusion of ions in porous electrodes for capacitive extraction of renewable energy from salinity differences Raúl A. Rica, Roberto Ziano,, Domenico Salerno, Francesco Mantegazza, Martin Z. Bazant, Doriano Brogioli, Electrochimica Acta, Volume 92, 1 March 2013, Pages 304–314 • Capacitive Mixing for Harvesting the Free Energy of Solutions at Different Concentrations R. A. Rica, R. Ziano, D. Salerno, F. Mantegazza, R. van Roij, D. Brogioli, Entropy 15 (4), 1388-1407 (2013) • Capacitive mixing for the extraction of energy from salinity differences: survey of experimental results and electrochemical models D. Brogioli, R. Ziano, R.A. Rica, D. Salerno, F. Mantegazza, Journal of Colloid and Interface Science, Volume 407, 1 October 2013, Pages 457–466 • Energy from CO2 Emissions H. V. M. Hamelers, O. Schaetzle, J. M. Paz-García, P. M. Biesheuvel, and C. J. N. Buisman Environ. Sci. Technol. Lett., 2014, 1 (1), pp 31–35

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CARE

From 2014-01-01 to 2016-12-31

Curriculum Quality Analysis and Impact Review of European ECEC

Objective In line with the EU strategies for 2020 and the need for a systemic and integrated approach to Early Childhood education and Care (ECEC), the project identifies eight key issues and questions for which effective policy measures and instruments should be developed. They concern assessing the impact of ECEC, optimizing quality and curricula for ECEC to increase effectiveness, raising the professional competencies of staff, monitoring and assuring quality of ECEC, increasing the inclusiveness of ECEC, in particular for socioeconomically disadvantaged children, funding of ECEC, and the need for innovative European indicators of children’s wellbeing. The project will address these issues in an integrative way by combining state-of-the-art knowledge of factors determining personal, social and economic benefits of ECEC with knowledge of the mechanisms determining access to and use of ECEC. In developing a European knowledge base for ECEC, we will add to the existing knowledge in two ways. First, we will include recent and

Project details

Project reference: 613318 Status: Accepted Total cost: EUR 3 285 284 EU contribution: EUR 2 498 607 Programme acronym: FP7-SSH Subprogramme area: SSH.2013.3.2-2 Contract type: Small or medium-scale focused research project

Coordinator

UNIVERSITEIT UTRECHT - Nederland

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ongoing ECEC research from several European countries. Second, we will include the perspectives of important stakeholders and integrate cultural beliefs and values. The central aim is to develop an evidence-based and culture-sensitive framework of: (a) Developmental goals, quality assessment, curriculum approaches and policy measures for improving the quality and effectiveness of ECEC; and (b) Effective strategies of organizing, funding and governing ECEC that increase the impact of ECEC. Our interdisciplinary research team will construct this framework, based on the competencies and skills that young children need to develop in current societies, identify the conditions that have to be fulfilled to promote child development and wellbeing, and identify strategies and policy measures that support access to high quality provisions, and likely to receive broad support of stakeholders, thereby enhancing the impact of ECEC.

Participants • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD - United Kingdom • KATHOLIEKE UNIVERSITEIT LEUVEN - Belgique/België • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • JYVASKYLAN YLIOPISTO - Suomi/Finland • HELLENIC OPEN UNIVERSITY - Hellas • INSTITUTO UNIVERSITARIO DE LISBOA - Portugal • HOGSKOLEN I VESTFOLD - Norge • UNIWERSYTET WARSZAWSKI - Polska • FREIE UNIVERSITAET BERLIN - Deutschland • AARHUS UNIVERSITET - Danmark

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

CASCATBEL

From 2013-11-01 to 2017-10-31 • CASCATBEL: www.cascatbel.eu

CAScade deoxygenation process using tailored nanoCATalysts for the production of BiofuELs from lignocellullosic biomasss

Objective The present project is aimed to the development of a multi-step process for the production of second-generation biofuels from lignocellulosic biomass in a cost-efficient way through the use of tailored nanostructured catalysts. The proposed process is based on the cascade combination of three catalytic transformations: catalytic pyrolysis, intermediate deoxygenation and hydrodeoxygenation. The sequential coupling of catalytic steps will be an essential factor for achieving a progressive and controlled biomass deoxygenation, which is expected to lead to liquid biofuels with a chemical composition and properties similar to those of oil-derived fuels. According to this strategy, the best nanocatalytic system in each step will be selected to deal with the remarkable chemical complexity of lignocellulose pyrolysis products, as well as to optimize the bio-oil yield and properties. Since hydrodeoxygenation

Project details

Project reference: 604307 Status: Execution Total cost: EUR 9 340 505 EU contribution: EUR 6 380 116 Programme acronym: FP7-NMP Subprogramme area: NMP.2013.1.1-1 Contract type: Large-scale integrating project

Coordinator

FUNDACION IMDEA ENERGIA - España

(HDO) is outlined in this scheme as the ultimate deoxygenation treatment, the overall hydrogen consumption should be strongly minimized, resulting in a significant improvement of the process economic profitability. The use of nanostructured catalysts will be the key tool for obtaining in each chemical step of the cascade process, the optimum deoxygenation degree, as well as high efficiency, in terms both of matter and energy, minimizing at the same time the possible environmental impacts. The project will involve experiments at laboratory, bench and pilot plant scales, as well as a viability study of its possible commercial application. Thereby, the integrated process will be assessed according to technical, economic, social, safety, toxicological and environmental criteria. The consortium will be formed by 18 partners, including 4 research institutions, 7 universities, 5 large industries and 2 SME.

Participants • • • • • • • • • • • • • •

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia TECHNISCHE UNIVERSITAET HAMBURG-HARBURG - Deutschland UNIVERZITA KARLOVA V PRAZE - Ceska Republika UNIVERSITEIT UTRECHT - Nederland ENI S.P.A. - Italia ASTON UNIVERSITY - United Kingdom EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH - Suisse ABENGOA RESEARCH SL - España OUTOTEC GMBH - Deutschland SILKEM PROIZVODNJA ZEOLITOV DOO - Slovenija MAST CARBON INTERNATIONAL LTD - United Kingdom CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS - Hellas THE UNIVERSITY OF WARWICK - United Kingdom USTAV FYZIKALNI CHEMIE J. HEYROVSKEHO AV CR, V. V. I. Ceska Republika • ENCE INVESTIGACION Y DESARROLLO SAU - España • MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG - Deutschland • NANOLOGICA AB - Sverige

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CASI

From 2014-01-01 to 2017-06-30

Public Participation in Developing a Common Framework for Assessment and Management of Sustainable Innovation

Objective The proposal responds to the Horizon 2020 challenge called “Climate action, resource efficiency and raw materials”. In addition, it addresses the second specific challenge of the Mobilising and Mutual Learning Action Plans (MMLAP) topics, listed in the Science in Society call for proposals of the Capacities Work Programme 2013, namely “Assessment of sustainable innovation”. The project’s main objective will be to develop a methodological framework for assessing sustainable innovation and managing multi-disciplinary solutions through public engagement in the RTDI system by ensuring the commitment of a broad spectrum of societal stakeholders into its implementation, including industry, policy-makers, research organisations and academia, civil society organisations and the general public.

In achievement to the overall objective of the proposed action, the specific objectives include the development of: • A working definition of sustainable innovation, building on common definitions, academic literature as well as expert advice internal and external to the project consortium;

Project details

Project reference: 612113 Status: Accepted Total cost: EUR 4 473 404 EU contribution: EUR 3 897 381 Programme acronym: FP7-SIS Subprogramme area: SiS.2013.1.2-1 Contract type: Support actions

Coordinator

APPLIED RESEARCH AND COMMUNICATIONS FUND - Bulgaria

Participants • • • • • • • • • • • • • • • • • •

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ZENTRUM FUER SOZIALE INNOVATION - Österreich KATHOLIEKE UNIVERSITEIT LEUVEN - Belgique/België UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia TECHNISCHE UNIVERSITAET DORTMUND - Deutschland THE UNIVERSITY OF MANCHESTER - United Kingdom KULUTTAJATUTKIMUSKESKUS - Suomi/Finland TECHNOLOGICA EAD - Bulgaria FUTURES DIAMOND SRO - Cescka Republika CLEANTECH BULGARIA FOUNDATION - Bulgaria MUNICIPIO DE ESPINHO - Portugal COVENTRY UNIVERSITY ENTERPRISES LIMITED - United Kingdom COMUNE DI MONZA - Italia FUNDACJA UNIWERSYTETU IM ADAMA MICKIEWICZA W POZNANIU Polska FONDEN TEKNOLOGIRÅDET - Danmark INOVAMAIS - SERVICOS DE CONSULTADORIA EM INOVACAO TECNOLOGICA S.A. - Portugal META GROUP S.R.L. - Italia INCREASE TIME SA - Portugal UNIVERZA NA PRIMORSKEM UNIVERSITA DEL LITORALE - Slovenija

• Ways to include general public concerns in assessing the social impact of these innovations on society in consultation workshops. Issues such as participation in the development of innovation, inclusiveness, ethics, gender and open access will be considered in these sessions; • A common understanding of best practices in sustainable innovation management; • A framework for assessment and management of sustainable innovations; • Specific policy recommendations on how to improve innovation management and how sustainability considerations can be incorporated into it based on the findings of the assessment framework and public consultations.

CASI mobilises 19 partners from 12 EU Member States. Through a network of country correspondents CASI will cover the whole of Europe. The work is structured in 11 work packages, and the mandatory work packages as outlined in the call are included.

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

CATSENSE

From 2014-01-01 to 2017-12-31 • CATSENSE: www.catsense.eu

Design of novel high performance catalysts and biosensors based on deposited mass-selected clusters assisted by computational theoretical screening

Objective The main S&T objective of CATSENSE is to design novel high performance catalysts and biosensors by a new interactive approach combining i). the production of mono and bi-metallic gas-phase clusters of controlled homogeneity, ii). the extensive characterisation of their morphology, structure (ex and in situ) and optical properties, iii). theoretical modelling and screening, and iv). catalytic and biosensing laboratory tests. Prototypes of the most promising catalyst and biosensor will be tested in realistic operative conditions through intense collaboration with our industrial partners.

Biosensing and Catalysis applications are of paramount importance in Europe nowadays and are directly related to core issues of the Renewed

Project details

Project reference: 607417 Status: Accepted Total cost: EUR 3 938 144 EU contribution: EUR 3 938 144 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2013-ITN Contract type: Networks for Initial Training (ITN)

Coordinator

Lisbon strategy, i.e, Health and Environment, respectively. Combining these technologies in a new supra-discipline of cluster-based nanotechnology will allow CATSENSE to contribute to the challenges that nanotechnology is now facing in Europe: a poor commercialisation track record of new discoveries and a shortage of adequately trained professionals. The training program will deliver nanotechnology experts corresponding to the need of the job market through a multi-level interdisciplinary and intersectorial network. The balanced program combines local expert training by academia and industrial partners, a network-wide secondment scheme, and a dense seminar, workshop and school schedule.

Participants • DANMARKS TEKNISKE UNIVERSITET - Danmark • TEL AVIV UNIVERSITY - Israel • UNIVERSITÀ DEGLI STUDI DI MILANO - Italia • THE UNIVERSITY OF BIRMINGHAM - United Kingdom • TEER COATINGS LIMITED - United Kingdom • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

KATHOLIEKE UNIVERSITEIT LEUVEN - Belgique-België

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

CESSDA-PPP

From 2008-01-01 to 2010-06-30 • CESSDA-PPP: www.cessda.org/project

Preparatory phase project for a major upgrade of the council of european social science data archives (cessda) research infrastructure

Objective This proposal for a major upgrade to the CESSDA Research Infrastructure is a response to the general principles and vision set out in the 2004 Blueprint for the European Research Obsrvatory for the Humanities and Social Science and will meet the goals set out in that report to strengthen interdisciplinary and cross-border collaboration and comparative research on a European dimension enhance the building of research infrastructure capacity in the less resourced European countries of today [and] it will increase the opportunity to improve knowledge on social processes and

thus holds great potential in terms of advising European and national policy-makers on how to manage the challenges currently faced by the societies of Europe. Building on the existing operational structure of the Council of European Social Science Data Archives (CESSDA) network of data archives and its associated partners, this proposal for a major RI upgrade will seek to address the major gaps and deficiencies identified by the EROHS report on Research Infrastructures through the facilitation of access to and sharing of existing European and national data.

Project details

Report Summary

Project reference: 212214 Status: Completed Total cost: EUR 4 164 974 EU contribution: EUR 2 675 250 Programme acronym: FP7-INFRASTRUCTURES Subprogramme area: INFRA-2007-2.2-01 Contract type: Integrating activities / e-infrastructures / preparatory phase

• Periodic Report Summary - CESSDA-PPP (PREPARATORY PHASE PROJECT FOR A MAJOR UPGRADE OF THE COUNCIL OF EUROPEAN SOCIAL SCIENCE DATA ARCHIVES RESEARCH INFRASTRUCTURE)

Coordinator University of Essex - United Kingdom

Result in Brief

• Social sciences powerhouse

Participants • UNIVERZA V LJUBLJANI - Slovenija

• CENTRO DE INVESTIGACIONES SOCIOLOGICAS - España

• UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

• UNIVERSITATEA DIN BUCURESTI - Romania

• WIENER INSTITUT FUR SOCIALWISSENSCHAFTLICHE

• FONDATION SUISSE POUR LA RECHERCHE EN SCIENCES

DOKUMENTATION UND METHODIK - Österreich

SOCIALES - Schweiz/Suisse/Svizzera

• GOETEBORGS UNIVERSITET - Sverige • TAMPEREEN YLIOPISTO - Suomi/Finlanld • GESIS - LEIBNIZ INSTITUT FUR SOZIALWISSENSCHAFTEN E.V. Deutschland • KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN KNAW - Nederland • STATENS ARKIVER - Danmark • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - France • NORSK SAMFUNNSVITENSKAPELIG DATATJENESTE AS - Norge • NATIONAL CENTRE FOR SOCIAL RESEARCH - EKKE - Hellas • TARKI TARSADALOMKUTATASI INFORMATIKA EGYESULES Magyarorszag • INSTITUTE OF SOCIOLOGY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC PUBLIC RESEARCH INSTITUTION Ceska Republika

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CHEETAH

From 2014-01-01 to 2017-12-31

Cost-reduction through material optimisation and Higher EnErgy outpuT of solAr pHotovoltaic modules - joining Europe’s Research and Development efforts in support of its PV industry

Objective Europe has invoked the SET-Plan to design and implement an energy technology policy for Europe to accelerate the development and deployment of cost-effective renewable energy systems, including photovoltaics. With lower cost of solar electricity, PV could significantly contribute to the achievements of the 20-20-20 objectives.

The Joint Program on PV of the European Energy Research Alliance (EERA-PV) aims to increase the effectiveness and efficiency of PV R&D through alignment and joint programming of R&D of its member institutes, and to contribute to the R&D-needs of the Solar Europe Industry Initiative.

In CHEETAH, all EERA-PV members will, through collaborative R&D activities, (1) focus on solving specific bottlenecks in the R&D Joint Program of EERA-PV, (2) strengthen the collaboration between PV R&D performers in Europe through sharing of knowledge, personnel and facilities, and (3) accelerate the implementation of developed technologies in the European PV industry. Specifically, CHEETAH R&D will support Pillar A (performance en-

Project details

Project reference: 609788 Status: Accepted Total cost: EUR 13 282 470 EU contribution: EUR 9 696 132 Programme acronym: FP7-ENERGY Subprogramme area: ENERGY.2013.10.1.5 Contract type: CPCSA

Coordinator

STICHTING ENERGIEONDERZOEK CENTRUM NEDERLAND Nederland

14

hancement & energy cost reduction) of the SEII Implementation Plan, through materials optimization and performance enhancement.

CHEETAH’s objectives are threefold: 1) Developing new concepts and technologies for wafer-based crystalline silicon PV (modules with ultra-thin cells), thin-film PV (advanced light management) and organic PV (very low-cost barriers), resulting in (strongly) reduced cost of materials and increased module performance; 2) Fostering long-term European cooperation in the PV R&D sector, by organizing workshops, training of researchers, efficient use of infrastructures; 3) Accelerating the implementation of innovative technologies in the PV industry, by a strong involvement of EPIA and EIT-KIC InnoEnergy in the program.

It is the ambition of CHEETAH to develop technology and foster manufacturing capabilities so that Europe can regain and build up own manufacturing capacity in all parts of the value chain in due time.

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Participants • INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW Belgique/België

• ZENTRUM FUR SONNENENERGIE- UND WASSERSTOFFFORSCHUNG BADEN-WURTTEMBERGSTIFTUNG - Deutschland

• TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU - Turkey

• TEKNOLOGIAN TUTKIMUSKESKUS VTT - Suomi/Finlanld

• STIFTELSEN SINTEF - Norge

• CENTRO DE INVESTIGACIONES ENERGETICAS,

• FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V - Deutschland • FORSCHUNGSZENTRUM JUELICH GMBH - Deutschland • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE United Kingdom • ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Schweiz/Suisse/Svizzera • UNIVERSIDAD POLITECNICA DE MADRID - España

MEDIOAMBIENTALES Y TECNOLOGICAS-CIEMAT - España • JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION Belgique/België • EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT - Schweiz/Suisse/Svizzera • INSTITUTT FOR ENERGITEKNIKK - Norge • UNIVERSITÀ DEGLI STUDI DI ROMA TORVERGATA - Italia • EUROPEAN PHOTOVOLTAIC INDUSTRY ASSOCIATION Belgique/België

• LOUGHBOROUGH UNIVERSITY - United Kingdom

• TALLINNA TEHNIKAULIKOOL - Eesti

• AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH - Österreich

• AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L’ENERGIA

• FUNDACION TECNALIA RESEARCH & INNOVATION - España

E LO SVILUPPO ECONOMICO SOSTENIBILE - Italia

• DANMARKS TEKNISKE UNIVERSITET - Danmark • UNIVERSITAT POLITECNICA DE VALENCIA - España • FORSCHUNGSVERBUND BERLIN E.V. - Deutschland • ALMA CONSULTING GROUP SAS - France • COMMISSARIAT A L’ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES - France • HELMHOLTZ-ZENTRUM BERLIN FUR MATERIALIEN UND ENERGIE GMBH - Deutschland • NPL MANAGEMENT LIMITED - United Kingdom • KENTRO ANANEOSIMON PIGON KE EXIKONOMISIS ENERGEIAS (CENTRE FOR RENEWABLE ENERGY SOURCES AND SAVING) Hellas • KIC INNOENERGY SE - Nederland • LABORATORIO NACIONAL DE ENERGIA E GEOLOGIA I.P. - Portugal • MIDDLE EAST TECHNICAL UNIVERSITY - Turkey

15

CISSTEM

From 2008-10-01 to 2012-03-31 • CISSTEM: www.cisstem.org

Cis-regulatory logic of the transcriptional control in neural stem cells

Objective Neural stem cells (NSCs) have emerged as a major topic in neurobiology.

The persistence of multipotent cells in the adult mammalian brain offers a realistic chance for the treatment of neurodegenerative diseases. It is thus crucial to understand NSCs from as many as possible angles (e. g. cellular and molecular biology), in order to better isolate and successfully manipulate them. CISSTEM presents a post-genomic systems biology approach, taking advantage of new computational and experimental tools to address the specification and maintenance of NSCs at the transcriptional/epigenetic level.

CISSTEM is designed to unravel the basic principles of gene regulation in

NSC, with a focus on cis-regulatory modules (CRMs). To do so we follow a multidisciplinary approach tightly interconnecting computational prediction and experimental validation in vitro and in vivo using different vertebrate models systems. Major intermediate objectives of this project are the prediction of relevant elements and the identification of the temporal, spatial and quantitative activities of predicted conserved regulatory motifs associated with NSC expressed genes. To achieve this goal, CISSTEM will develop computational tools and resources for the in silico identification of CRMs and transcription factor binding sites (TFBSs).

Project details

Coordinator

Project reference: 223210 Status: Completed Total cost: EUR 4 002 786 EU contribution: EUR 2 984 169 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH-2007-2.1.2-5 Contract type: Small or medium-scale focused research project

Result in Brief

• Unveiling the genomic architecture in neural stem cells

Report Summary

• Periodic Report Summary 1 - CISSTEM (Cis-regulatory logic of the transcriptional control in neural stem cells) • Periodic Report Summary 2 - CISSTEM

Publications (5)via OpenAIRE

• Transcription factors: from enhancer binding to developmental control Francois Spitz - Eileen E. M. Furlong • Ensembl 2012.

Paul Flicek - M Ridwan Amode - Daniel Barrell - Kathryn Beal - Simon Brent - Denise Carvalho-Silva - Peter Clapham - Guy Coates - Susan Fairley - Stephen Fitzgerald - Laurent Gil - Leo Gordon - Maurice Hendrix - Thibaut Hourlier - Nathan Johnson - Andreas K Kähäri - Damian Keefe - Stephen Keenan - Rhoda Kinsella - Monika Komorowska - Gautier Koscielny - Eugene Kulesha - Pontus Larsson - Ian Longden - William McLaren Matthieu Muffato - Bert Overduin - Miguel Pignatelli - Bethan Pritchard - Harpreet Singh Riat - Graham R S Ritchie - Magali Ruffier - Michael Schuster - Daniel Sobral - Y Amy Tang - Kieron Taylor - Stephen Trevanion - Jana Vandrovcova - Simon White Mark Wilson - Steven P Wilder - Bronwen L Aken - Ewan Birney - Fiona Cunningham - Ian Dunham - Richard Durbin - Xosé M Fernández-Suarez - Jennifer Harrow - Javier Herrero - Tim J P Hubbard - Anne Parker - Glenn Proctor - Giulietta Spudich - Jan Vogel - Andy Yates - Amonida Zadissa - Stephen M J Searle • Annotating genes and genomes with DNA sequences extracted from biomedical articles Maximilian Haeussler - Martin Gerner - Casey M. Bergman

16

INSTITUT NATIONALE DE LA RECHERCHE AGRONOMIQUE INRA France

Participants • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) France • RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG - Deutschland • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • THE UNIVERSITY OF MANCHESTER - United Kingdom • EUROPAISCHES LABORATORIUM FUR MOLEKULARBIOLOGIE Deutschland • INRA TRANSFERT S.A. - France • KARLSRUHER INSTITUT FUER TECHNOLOGIE - Deutschland • MEDICAL RESEARCH COUNCIL - United Kingdom

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

COMSODE

From 2013-10-01 to 2015-09-30

Components Supporting the Open Data Exploitation

Objective The project COMSODE (Components Supporting the Open Data Exploitation) is an SME-driven RTD project aimed at progressing the capabilities in the Open Data re-use field. The goal is an answer to barriers still present in this young area: data published by various open data catalogues are poorly integrated; quality assessment and cleansing are seldom addressed. Data consumers have to integrate the data before they can use them which increases significantly the costs of open data consumption and hinder open data usage and uptake, etc. COMSODE has the following main objectives: (1) Create a publication platform called Open Data Node that builds on results of previous research and development in the linked data field. Its mission is to bring results from research environment into real-world for people, SMEs and other organizations to use and reuse. (2) Create a methodological framework for easy use of technology in operating conditions of typical public bodies and rigorously tested for traceability, usability and sustainability in a public body environment. This is going to be verified in three pilot implementations during the project.

End user-communities will be involved EU-wide to set a use case framework within which the requirements of heterogeneous organisations can

Project details

Project reference: 611358 Status: Execution Total cost: EUR 1 839 863 EU contribution: EUR 1 469 000 Programme acronym: FP7-ICT Subprogramme area: ICT-2013.4.3 Contract type: Collaborative project (generic)

Publications

be clearly understood. Provided feedback will be processed into the final methodology and recommendations for re-use applications. These two results will enable new applications to emerge – some of them will be directly created in the project by consortium members (search service

by SPINQUE) or by associated bodies (Semantic Web Company, Austria).

The project will cooperate with activities under progress in the EU and internationally (consortium members were personally involved in many of them: e.g. LOD2, OGP, etc.). It is a project ambition to lay the foundations for a data integration platform based on Open Data which will allow the re-use of data not only between public bodies and end-users but also among public bodies themselves: Public bodies can exchange information by using the same infrastructure and tools as end-users which will decrease costs of exchanging the data and in most cases also enhance the quality and speed-up of the exchange. What is even more important, OpenData APIs can be used by integration projects between public bodies, again saving costs and enhancing the quality of the resulting solution.

This in turn strengthens OpenData publishing, with end-users benefiting again – a self reinforcing loop.

Participants • ADDSEN SRO - Slovenska Republika • UNIVERZITA KARLOVA V PRAZE - Ceska Republika • MINISTRY OF INTERIOR OF THE SLOVAK REPUBLIC Slovenska Republika • SPINQUE BV - Nederland • EEA SRO - Ceska Republika

• Comsode D7.1 fact sheet

Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

17

CONTROLLED SYSTEMS

From 2008-10-01 to 2012-09-30

Deterministic and stochastic controlled systems and applications

Objective Experienced Researchers from the Universities of Iasi, Brest, Jena, Manchester, Marrakech and Milano propose an Initial Training Network Marie Curie on the theme “Deterministic and Stochastic Controlled Systems and Applications”. This project aims to unite the six teams with their complementary competences in - Controlled Systems: Deterministic and Stochastic Control, Game Theory, - Stochastic Equations: Stochastic Differential Equations, Stochastic Partial Differential Equations, Backward Stochastic Differential Equations, and - Levy processes as well as fractal processes, in order to investigate problems arising in the interaction between these competences and allowing to study, in cooperation with our industrial partners (coming from the bank and insurance sector), related problems in - Finance and Insurance, but also in - Natural Sciences, namely, the problem of transport in porous media.

The Early-Stage Researchers and the Experienced Researchers recruited by

Project details

Project reference: 213841 Status: Completed Total cost: EUR 3 761 677 EU contribution: EUR 3 761 677 Programme acronym: FP7-PEOPLE Subprogramme area: PEOPLE-2007-1-1-ITN Contract type: Networks for Initial Training (ITN)

Result in Brief

• Modelling financial, insurance and scientific data

Report Summary

• Periodic Report Summary - CONTROLLED SYSTEMS (Deterministic and Stochastic Controlled Systems and Applications)

Publications (39)via OpenAIRE

• A BSDE approach to stochastic differential games with incomplete information Christine Grün • A stochastic approach to a new type of parabolic variational inequalities Tianyang Nie • Stochastic representation for solutions of Isaacs’ type integral-partial differential equations Rainer Buckdahn - Ying Hu - Juan Li

Coordinator

UNIVERSITATEA ALEXANDRU IOAN CUZA - Romania

18

the network will be integrated from the early beginning in research projects between teams with complementary competences which should allow them (as well as the qualified researchers from the different teams) to profit from synergy effects and find quite new answers to the research problems. Besides an individual research training under supervision of qualified researchers and a local training programme the young researcher will also profit from network-wide training offers including namely - annual schools on subjects reflecting the different competences of the network teams, - a first professional experience in research with one of our industrial partners, as well as - workshops and international conferences which will give to the young researchers the possibility to present and discuss their results in research and to find contacts also with researchers outside the network and representatives of all the industrial partners of our network.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • UNIVERSITÉ DE BRETAGNE OCCIDENTALE - France • FRIEDRICH-SCHILLER-UNIVERSITAET JENA - Deutschland • UNIVERSITÉ CADI AYYAD - Morocco • THE UNIVERSITY OF MANCHESTER - United Kingdom

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

DECORE

From 2013-01-01 to 2016-12-31 • DECORE: www.decore.eucoord.com

Direct ElectroChemical Oxidation Reaction of Ethanol: optimization of the catalyst/support assembly for high temperature operation (DECORE)

Objective The main general goal of DECORE is to achieve the fundamental knowledge needed for the development of a fuel cell (FC) electrode, which can operate efficiently (both in terms of activity and selectivity) as the anode of a direct ethanol (EOH) FC (DEFC) in the temperature range between 150200 °C (intermediate-T). Such a technology is still lacking in the market.

The choice for EOH as an alternative energy source is well founded on the abundance of bioethanol, and on the relatively simpler storage and use with respect to other energy carriers. The intermediate-T is required for an efficient and selective total conversion of EOH to CO2, so exploiting the maximum number of electrons in the DEFC. DECORE will explore the use of fully innovative supports (based on titanium oxycarbide, TiOxCy) and nano-catalysts (based on group 6 metal carbides, MCx, M=Mo,W), which have never been tested in literature as anodes for

Project details

Project reference: 309741 Status: Execution Total cost: EUR 3 070 020 EU contribution: EUR 2 341 664 Programme acronym: FP7-NMP Subprogramme area: NMP.2012.1.1-1 Contract type: Small or medium-scale focused research project

Coordinator

DEFCs. The new support is expected to be more durable than standard carbon supports at the targeted temperature. The innovative nano-catalysts would be noble-metal free, so reducing Europes reliance on imported precious metals. To tailor the needed materials, the active role of the support and nano-catalyst will be studied at atomic level.

Demonstrating an activity of such nano-catalyst/support assembly at intermediate-T would open a novel route where DEFCs with strongly reduced production costs would have an impact on a fast industrialisation. The power range for the envisioned application is of the order of hundreds of Watts, i.e. the so called distributed generation, having an impact for devices such as weather stations, medical devices, signal units, auxiliary power units, gas sensors and security cameras. By the end of the project, a bench-top single DEFC operating at intermediate-T will be built and tested.

Participants • TECHNISCHE UNIVERSITAET MUENCHEN - Deutschland • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • CONSIGLIO NAZIONALE DELLE RICERCHE - Italia • UNIVERSIDAD DE LA LAGUNA - España • KOBENHAVNS UNIVERSITET - Danmark • ELCOMAX GMBH - Deutschland

UNIVERSITÀ DEGLI STUDI DI PADOVA - Italia

19

ECO

From 2009-10-01 to 2013-09-30

Environmental chemoinformatics

Objective The implementation of the new EU legislation concerning the registration, evaluation, authorization and restriction of chemicals (REACH) requires demonstration of the safe manufacture of chemicals and their safe use throughout the supply chain.

REACH encourages development of new in vitro test methods and replacement of animal tests wherever possible by alternative methods. These goals are not achievable without well-trained personnel with a broad expertise and knowledge in both experimental and computational areas of environmental sciences. The requirements for such scientists, however, are not limited to the REACH implementation itself.

Large companies and SMEs could be interested to employ such specialists to perform risk assessment and prioritization of molecules in the development stage. Therefore, the primary objective of this ITN (http://www.eco-itn.eu) is to contribute to the education of a new generation of scientists, environmental chemoinformaticans, who will receive advanced training in both environmen-

Project details

Project reference: 238701 Status: Completed Total cost: EUR 3 386 676 EU contribution: EUR 3 386 676 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-ITN-2008 Contract type: Networks for Initial Training (ITN)

Result in Brief

• Modelling financial, insurance and scientific data

Publications (6)via OpenAIRE

• Acute toxicity of poly and perfluorinated compounds to two cladocerans, Daphnia magna and Chydorus sphaericus Guang-Hui Ding - Tobias Froemel - Evert-Jan van den Brandhof Rob Baerselman - Willie J. G. M. Peijnenburg • Comparison of Different Approaches to Define the Applicability Domain of QSAR Models Faizan Sahigara - Kamel Mansouri - Davide Ballabio - Andrea Mauri - Viviana Consonni - Roberto Todeschini • Compound Lipophilicity as a Descriptor to Predict Binding Affinity (1/K-m) in Mammals Alessandra Pirovano - Mark A. J. Huijbregts - Ad M. J. Ragas - A. Jan Hendriks

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGS ZENTRUM FUER GESUNDHEIT UND UMWELT GMBH - Deutschland

20

tal and computational methods.

To achieve this goal the ITN will train the fellows using expertise and knowledge of its partners in various complementary computational and experimental areas of environmental sciences. The additional training will also be offered by means of Winter and Summer Schools and will include both theoretical and practical courses.

The internships to the laboratories of associated partners will allow fellows to learn new methods and to broaden their knowledge in the field. A flexible system of Short Term Fellowships will offer additional targeted training to researchers originally not associated with the network.

Given the potentially great business impact of evaluating more than 120,000 industrial chemicals in the European market within the next decade, the fellows of this network may have a significant economic dimension with regard to the hazard evaluation of chemicals in Europe.

Participants • HOCHSCHULE FRESENIUS GEMEINNUETZIGE GMBH Deutschland • STICHTING KATHOLIEKE UNIVERSITEIT - Nederland • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • LINNEUNIVERSITETET - Sverige • UNIVERSITEIT LEIDEN - Nederland • INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA - España

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

EDONHIST

From 2013-03-01 to 2017-02-28

Electronic DOped colloidal Nanocrystal Heterostructures with designed Interfacial composition: towards the development of new nano-device conceptS for lightning and energy Technologies

Objective Lighting is responsible for over 20% of global electricity usage, most of which is wasted due to the low efficiency of current technologies. Unlike these, Solid-State Lighting (SSL) has the potential to be a 100% efficient technology. Colloidal nanocrystals (NC) are ideal candidates for this application as they exhibit efficient, tenable emission and can be processed in solution. Their applicability is however hindered by nonradiative Auger recombination (AR), the difficulty of achieving balanced electron/hole currents in LEDs and small Stokes shifts which increase the losses by self-absorption. These issues can be addressed by engineering the confinement potential in NC heterostructures and through electronic doping. This project aims at combining these two strategies for achieving highly efficient, lowcost SSL devices that can be implemented in real-world technologies. This goal implies a dedicated synthesis effort and deep understanding of the physical and chemical processes occurring in the NCs and a strong multi-

Project details

Project reference: 324603 Status: Execution Total cost: EUR 100 000 EU contribution: EUR 100 000 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2012-CIG Contract type: Support for training and career development of researcher (CIG)

disciplinary approach. The structural and optical properties will be investigated with advanced spectroscopic techniques some of which pioneered by the candidate. LEDs will be fabricated and optimized for maximizing their performance. The results will have strong impact on all aspects of NC research: 1) Development of synthesis protocols for producing NCs unaffected by AR and exhibiting new functionalities; 2) achievement of deeper understanding of the photophysical processes especially with regard to the role of interfaces on suppression of AR and the involvement of dopants in the recombination processes of NCs; 3) Design and realization of new SSL sources (white and monochromatic) also based on new operation paradigms made possible by the new functionalities of the advanced NCs. The project will also have strong impact on the candidates reintegration as it will allow him to establish his independent line of research within the host organization.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

21

ENCCA

From 2011-01-01 to 2014-12-31 • ENCCA: www.encca.eu

European network for cancer research in children and adolescents

Objective ENCCA aims to establish a durable, European Virtual Institute on clinical and translational research in childhood and adolescent cancers that will define and implement an integrated research strategy and methodology and will facilitate the necessary investigator-driven clinical trials to introduce the new generation of biologically targeted drugs into standard of care for children and adolescents with cancer. This will lead to more efficacious and less toxic therapies that will maximise the quality of life of the increasing number of survivors of cancer at a young age in Europe and allow them to assume their proper place in society. This biologically-driven research agenda will improve training of the clinical investigators and translational scientists of the future to spread excellence, increase capacity to participate in research and monitor outcomes across Europe. Patients and their families will be full partners and will be better informed about the need for and processes of clinical research.

They will be in a better situation to care from their long term health risks for children. Drug development will be accelerated in partnership with industry through improved access to young patients with cancer, to academic expertise in care, clinical and biological research. All of this will be achieved with respect for the highest ethical and patient safety standards. ENCCA will bring all stakeholders to the table in a timely and efficacious manner. It will address the needs of all the current multinational clinical trial groups for the benefit of children with cancer. It will provide them with common tools and approaches to solve the bottlenecks in testing new therapeutic strategies for those rare diseases in a vulnerable age group and in running a competitive clinical research agenda. Ongoing efforts to coordinate EU and US clinical research will be reinforced. ENCCA will be led by the most active EU institutes in the field (31), recognised as being at the forefront of excellence.

Project details

Publications via OpenAIRE

Project reference: 261474 Status: Execution Total cost: EUR 13 493 973 EU contribution: EUR 11 997 958 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH.2010.2.4.1-3 Contract type: Networks of Excellence

Result in Brief

• Enhancing quality of life for young cancer survivors

Documents

• Periodic Report 2 - ENCCA (European network for cancer research in children and adolescents)

Report Summary

• Periodic Report Summary - ENCCA • Periodic Report Summary 2 - ENCCA

Coordinator

ST. ANNA KINDERKREBSFORSCHUNG - Österreich

22

• Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice Lukas C. Heukamp - Theresa Thor - Alexander Schramm Katleen De Preter - Candy Kumps - Bram De Wilde - Andrea Odersky - Martin Peifer - Sven Lindner - Annika Spruessel - Filip Pattyn - Pieter Mestdagh - Bjoern Menten - Steffi Kuhfittig-Kulle - Annette Kuenkele - Katharina Koenig - Lydia Meder - Sampurna Chatterjee - Roland T. Ullrich - Stefanie Schulte - Jo Vandesompele - Frank Speleman - Reinhard Buettner - Angelika Eggert - Johannes H. Schulte • Performance of binary markers for censored failure time outcome: nonparametric approach based on proportions Laura Antolini - Maria Grazia Valsecchi • Taking the long view: how to design a series of Phase III trials to maximize cumulative therapeutic benefit Marie-Cecile Le Deley - Karla V. Ballman - Julien Marandet Daniel Sargent

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Participants • FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS Hellas • CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER France • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM - Nederland • UNIVERSITAETSKLINIKUM ESSEN - Deutschland • WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Deutschland • KAROLINSKA INSTITUTET - Sverige • CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL - Deutschland • UNIVERSITEIT GENT - Belgique/België • UNIVERSITY COLLEGE LONDON - United kingdom • UNIVERSITÀ DEGLI STUDI DI PADOVA - Italia • ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS - France • CHARITE - UNIVERSITAETSMEDIZIN BERLIN - Deutschland • ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Nederland • THE LEEDS TEACHING HOSPITALS NATIONAL HEALTH SERVICE TRUST - United Kingdom • LANDESHAUPTSTADT STUTTGART - Deutschland • OSTERREICHISCHE KINDER-KREBS-HILFE VERBAND DER OSTERREICHISCHEN KINDER KREBS HILFE ORGANISATIONEN Österreich • AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH - Österreich • INSTITUT CURIE - France • ESQH VIENNA OFFICE - EUROPAISCHE GESELLSCHAFT FUR QUALITAT IM GESUNDHEITSWESEN - WIENER BURO VEREIN Österreich • UNIVERSITÀ CATTOLICA DEL SACRO CUORE - Italia • ISTITUTO GIANNINA GASLINI - Italia

• • • • • • • • • • •

SIOP EUROPE - Belgique/België GDANSKI UNIWERSYTET MEDYCZNY - Polska UNIVERSITY OF LEEDS - United Kingdom CONSORZIO INTERUNIVERSITARIO CINECA - Italia THE UNIVERSITY OF BIRMINGHAM - United Kingdom UNIVERSITY OF SOUTHAMPTON - United Kingdom ACADEMISCH ZIEKENHUIS LEIDEN - LEIDS UNIVERSITAIR MEDISCH CENTRUM - Nederland CENTRE ANTICANCEREUX LEON BERARD - France FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA - España EUROPEAN CANCER ORGANISATION - Belgique/België INSTITUT GUSTAVE ROUSSY - France

23

ENCITE

From 2008-06-01 to 2012-11-30 • ENCITE: www.encite.org

European Network for Cell Imaging and Tracking Expertise

Objective Cell therapy can be defined as the transplantation of living cells for the treatment of medical disorders. Three different principles underlie the increasing interest in cell therapy. 1. Transplanted cells used as an active drug 2. Transplanted cells used to replace damaged and degenerated tissue. 3.

Cells used as a drug delivery vehicle. Promising results have been obtained in pre-clinical and clinical studies, however, success rates have been variable and clinical benefits have been limited. A major issue is the fact that the mechanisms by which cell therapy works in the different disease areas, are still poorly understood. The ability to non-invasively monitor the fate and modes of action of transplanted cells over time is mandatory. The development of relevant imaging tools will lead to a better understanding of how cell therapy works, the possibility of response monitoring in patients, and sufficient safety of the treatment. ENCITE will provide tools to allow this by

developing; New imaging methods to improve the spatio-temporal tracking of labelled cells Dual- and multimodality imaging procedures to cross-validate each individual approach; New contrast agents and procedures that will improve the sensitivity and specificity of cellular labelling Combining of molecular biology for the generation of molecular and cellular imaging reporters with multimodal imaging techniques; Novel cell and animal reporter systems detecting the location and function of individual cells and small cell subsets within the target organ Cellular labelling that does not interfere with cellular functions and therapeutic efficacy; Methods for quantitative assessment to generate reliable biomarkers of the cell fate and therapeutic effects Cell homing for therapeutic delivery to target organs. The tools and methodologies developed will be validated in 5 key disease areas; Neurological, Cardiovascular, Musculoskeletal, Diabetes and Cancer.

Project details

Publications (46)via OpenAIRE

Project reference: 201842 Status: Completed Total cost: EUR 15 503 366 EU contribution: EUR 11 997 945 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH-2007-1.2-4 Contract type: Large-scale integrating project

Result in Brief

• Imaging cell fate after cell therapy

Report Summary

• Periodic Report Summary 1 - ENCITE (European Network for Cell Imaging and Tracking Expertise) • Periodic Report Summary 2 - ENCITE • Final Report - ENCITE

Documents

• Periodic Report - ENCITE • Periodic Report 2 - ENCITE • Final Report - ENCITE

24

• Effects of MRI Contrast Agents on the Stem Cell Phenotype Annelies Crabbe - Caroline Vandeputte - Tom Dresselaers - Angel Ayuso Sacido - Jose Manuel Garcia Verdugo - Jeroen Eyckmans - Frank P. Luyten - Koen Van Laere - Catherine M. Verfaillie - Uwe Himmelreich • In vivo imaging of inhibitory, GABAergic neurons by MRI Markus Aswendt - Eliana Gianolio - Giorgio Pariani - Roberta Napolitano - Franco Fedeli - Uwe Himmelreich - Silvio Aime Mathias Hoehn • Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling Stefaan J. H. Soenen - Uwe Himmelreich - Nele Nuytten - Marcel De Cuyper

Coordinator

EIBIR GEMEINNUETZIGE GMBH ZUR FOERDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG - Österreich

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Participants • AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS - España • MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. - Deutschland • INSTITUT CURIE - France

• KING’S COLLEGE LONDON - United Kingdom • VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG Nederland • ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Nederland

• UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

• UNIVERSITAETSSPITAL BASEL - Schweiz/Suisse/Svizzera

• FRIEDRICH-ALEXANDER UNIVERSITAET ERLANGEN-

• ACADEMISCH ZIEKENHUIS LEIDEN - LEIDS UNIVERSITAIR

NUERNBERG - Deutschland • WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Deutschland • STICHTING KATHOLIEKE UNIVERSITEIT - Nederland • KATHOLIEKE UNIVERSITEIT LEUVEN - Belgique/België

MEDISCH CENTRUM - Nederland • UNIVERSITÉ DE MONS - Belgique/België • CONSORCI INSTITUT CATALÀ DE CIÈNCIES CARDIOVASCULARS España • MEDRES-MEDICAL RESEARCH GMBH - Deutschland

• TEL AVIV UNIVERSITY - Israel • THE HEBREW UNIVERSITY OF JERUSALEM - Israel • WEIZMANN INSTITUTE OF SCIENCE - Israel • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE - United kingdom • UNIVERSITÀ DEGLI STUDI DI TORINO - Italia • UNIVERSITAETSKLINIKUM FREIBURG - Deutschland • FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA España • INSTITUT KLINICKÉ A EXPERIMENTÁLNÍ MEDICINY - Ceska Republika • UNIVERSIDAD DE NAVARRA - España • CAGE CHEMICALS SRL - Italia • BIOSPACE LAB SA - France • UNIVERSITAETSKLINIKUM ERLANGEN - Deutschland • UNIVERSITÉ PARIS DESCARTES - France

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ENDOTOFPET-US

From 2011-01-01 to 2014-12-31

Novel multimodal endoscopic probes for simultaneous PET/ultrasound imaging for image-guided interventions

Objective In the frame of this project it is proposed to define and build a bi-modal PET-US (Positron Emission Tomography and Ultrasound) endoscopic probe combining in a miniaturized system a fully digital, 200ps time resolution Time of Flight PET detector head (TOF-PET) coupled to a commercial ultrasound (US) assisted biopsy endoscope and to launch the first steps of clinical validation. The project addresses and combines several objectives of the topics Health 2010. 1. 2-1, such as novel multimodality

Project details

Project reference: 256984 Status: Execution Total cost: EUR 10 397 115 EU contribution: EUR 5 516 001 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH.2010.1.2-1 Contract type: Small or medium-scale focused research project

Result in Brief

• Novel endoscopic tool advances cancer imaging

Report Summary

• Periodic Report Summary - ENDOTOFPET-US (Novel multimodal endoscopic probes for simultaneous PET/ultrasound imaging for image-guided interventions)

Coordinator

UNIVERSITÉ D’AIX MARSEILLE - France

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imaging tools, including a single photon (quantum) counting PET detector head for the purpose of identifying and quantifying morphologic and functional markers and of developing new biomarkers of tumoral processes at the preclinical and clinical levels. Moreover the endoscopic approach, combined with an unprecedented PET timing resolution will allow more sensitive, more precise, lower radiation dose and less invasive imaging and intervention on small internal structures and lesions.

Participants • LABORATORIO DE INSTRUMENTACAO E FISICA EXPERIMENTAL DE PARTICULAS - Portugal • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG - Deutschland • TECHNISCHE UNIVERSITAET MUENCHEN - Deutschland • STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY Deutschland • EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH Schweiz/Suisse/Svizzera • KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN - Deutschland • TECHNISCHE UNIVERSITEIT DELFT - Nederland • UNIVERSITÉ DE LA MEDITERRANEE D’AIX-MARSEILLE II France • FIBERCRYST SAS - France • KLOE SA - France • HOSPICES CANTONAUX CHUV - Schweiz/Suisse/Svizzera • SURGICEYE GMBH - Deutschland

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

ETSF

From 2008-01-01 to 2010-12-31 • ETSF: www.ei3.etsf.eu

European theoretical spectroscopy facility I3

Objective The European Theoretical Spectroscopy Facility addresses an important need of European science and technology by providing experimental, industrial and other researchers with access to state-of-the-art computer simulation tools for electronic excited states in matter, together with high-quality support from ETSF personnel, mirroring the massive progress in the power and resolution of new European experimental facilities.

All domains that need knowledge about electronic excitations, transport and spectroscopy will benefit from the ETSF, such as condensed matter physics and chemistry, biology, materials science and nanoscience, atmospheric science, and astrophysics. The ETSF provides users with computer codes, background knowledge, customised support and development, training, and collaborators to enhance their studies of the electronic and transport properties of complex or nanoscale materials. Its focus is on the rapid transfer of ground-breaking fundamental knowledge of matter, at the

Project details

Project reference: 211956 Status: Completed Total cost: EUR 4 374 911 EU contribution: EUR 3 800 000 Programme acronym: FP7-INFRASTRUCTURES Contract type: No contract type

Publications (139)via OpenAIRE

• Localized state and charge transfer in nitrogen-doped graphene Frederic Joucken - Yann Tison - Jerome Lagoute - Jacques Dumont - Damien Cabosart - Bing Zheng - Vincent Repain - Cyril Chacon - Yann Girard - Andres Rafael Botello-Mendez - Sylvie Rousset - Robert Sporken - Jean-Christophe Charlier - Luc Henrard • Charge-transfer in time-dependent density-functional theory via spin-symmetry-breaking Johanna I. Fuks - Angel Rubio - Neepa T. Maitra • Electronic properties of lanthanide oxides from the GW perspective Hong Jiang - Patrick Rinke - Matthias Scheffler

quantum-mechanical level, to detailed understanding and future-oriented design of prototypical or technologically relevant systems.

The ETSF has been successfully designed and recently brought into operation by the Nanoquanta Network of Excellence with the support of national and local institutions. In the present ETSF-I3 project, the ETSF is partnered by the Barcelona Supercomputing Centre to create a framework for deploying the ETSF infrastructure to a much wider range of users, through user training and projects supported by ETSF scientists.

The ETSF-I3 project will monitor the scientific and technological needs of users, and will boost the user-oriented development of ETSF software, algorithms and libraries made available on the most advanced computational platforms. ETSF-I3 will be crucial to keep the ETSF at the forefront of knowledge and establish it as the world-wide reference centre for modelling of electronic excited states.

Participants • • • • • • • • • • • • • •

ECOLE POLYTECHNIQUE - France COMMISSARIAT A L’ENERGIE ATOMIQUE - France CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - France CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS - España BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION - España MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. - Deutschland LUNDS UNIVERSITET - Sverige UNIVERSITÀ DEGLI STUDI DI MILANO - Italia FRIEDRICH-SCHILLER-UNIVERSITAET JENA - Deutschland FREIE UNIVERSITAET BERLIN - Deutschland UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA - España UNIVERSITÀ DEGLI STUDI DI ROMA “TOR VERGATA” - Italia UNIVERSITÉ CATHOLIQUE DE LOUVAIN - Belgique/België UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCA - Italia

Coordinator

UNIVERSITY OF YORK - United Kingdom

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EU-MASCARA

From 2011-12-01 to 2015-11-30 • EU-MASCARA: www.eu-mascara.eu

Markers for Sub-Clinical Cardiovascular Risk Assessemnt

Objective EU-MASCARA is a collaborative project that aims to improve diagnosis of cardiovascular diseases and prediction of cardiovascular risk by analysing a panel of biomarkers. EU-MASCARA aims to examine genetic, proteomic and metabolomic markers together with markers of inflammation, oxidative stress and cardiac remodelling to study their incremental diagnostic and predictive value over and above existing diagnostic and predictive algorithms. For this purpose a large number of cohorts from different European regions, both patient and population cohorts, that have been accurately assessed for cardiovascular phenotypes are readily available to the consortium. Access to clinical samples and to standardised cardiovascular phenotypes will be granted by a strong clinical platform as one of the key work packages of EU-MASCARA. Both cross-sectional and prospective analyses will be performed that will result in the development of improved risk prediction scores.

Project details

Project reference: 278249 Status: Execution Total cost: EUR 7 849 988 EU contribution: EUR 5 990 880 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH.2011.2.4.2-2 Contract type: Small or medium-scale focused research project

Publications (9)via OpenAIRE

• Significance of White-Coat Hypertension in Older Persons With Isolated Systolic Hypertension A Meta-Analysis Using the International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Population Stanley S. Franklin - Lutgarde Thijs - Tine W. Hansen - Yan Li Jose Boggia - Masahiro Kikuya - Kristina Bjoerklund-Bodegard - Takayoshi Ohkubo - Jorgen Jeppesen - Christian Torp-Pedersen - Eamon Dolan - Tatiana Kuznetsova - Katarzyna Stolarz-Skrzypek - Valerie Tikhonoff - Sofia Malyutina - Edoardo Casiglia - Yuri Nikitin - Lars Lind - Edgardo Sandoya - Kalina Kawecka-Jaszcz - Yutaka Imai - Jiguang Wang - Hans Ibsen - Eoin O’Brien - Jan A. Staessen • Urinary proteomics to support diagnosis of stroke Jesse Dawson - Matthew Walters - Christian Delles - Harald Mischak - William Mullen • Aldosterone and parathyroid hormone: a precarious couple for cardiovascular disease Andreas Tomaschitz - Eberhard Ritz - Burkert Pieske - Astrid Fahrleitner-Pammer - Katharina Kienreich - Joerg H. Horina Christiane Drechsler - Winfried Maerz - Michael Ofner - Thomas R. Pieber - Stefan Pilz

Coordinator

UNIVERSITY OF GLASGOW - United Kingdom

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The consortium is heavily supported by contributions of SMEs in key areas of the proposed research: biomarker testing, data handling and analysis, assay development and project management. EU-MASCARA is further characterised by a strong integrative approach both within and across work packages, with results from one task informing strategies of research in other tasks. With a dedicated bioinformatics and health economic platform the most robust biomarkers will be selected and analysed for their benefit in clinical practice.

EU-MASCARA will rigorously validate biomarkers that have been proposed to be associated with cardiovascular disease and risk across different disease entities and also in independent general population samples.

The most robust biomarkers will be implemented in novel biochip based assays for clinical use.

Participants • • • • • • • • • • • • • •

MEDIZINISCHE UNIVERSITAET GRAZ - Österreich KATHOLIEKE UNIVERSITEIT LEUVEN - Belgique/België UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia CHARITE - UNIVERSITAETSMEDIZIN BERLIN - Deutschland FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA España ISTITUTO AUXOLOGICO ITALIANO - Italia UNIVERSITEIT MAASTRICHT - Nederland EMERGENTEC BIODEVELOPMENT GMBH - Österreich MOSAIQUES DIAGNOSTICS GMBH - Deutschland KITE INNOVATION (EUROPE) LIMITED - United Kingdom ACS BIOMARKER BV - Nederland RANDOX CLINICS LIMITED - United Kingdom FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA - España MEDIZINISCHE HOCHSCHULE HANNOVER - Deutschland

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

FAMILYPLATFORM

From 2009-10-01 to 2011-03-31

Social platform on research for families and family policies

Objective The overall objective of the planned FAMILYPLATFORM is to elaborate a focussed research agenda that will address fundamental research issues and key policy questions for future research and family policies in Europe.

Therefore, the platform will match three relevant perspectives: The perspective of the scientific community, the perspective of European families represented by important stakeholders such as family and children’s rights associations, and the perspective of policy makers and social partners.

The FAMILYPLATFORM will focus on four areas: - Catching up with the current state of family research and elaboration of significant trends, differences between countries, gaps and methodological problems of existing research on families. Therefore a wide range of existential fields of family life and family policy will be taken into consideration.

- A critical review of existing research from the perspective of a wide range of stakeholder representatives such as family associations, children’s right associations and policy makers and social partners.

- Generating key policy questions for future European policy and research issues and tools focussed on well being of families as key concept in European policy.

- Working out a research agenda with fundamental research issues, research areas and tasks of long-term studies, methodological tools based on step 1-3.

The FAMILYPLATFORM offers a wide variety of forums: Conferences with debates to certain topics, workshops and future scenarios with defined tasks, focus groups for opinion formation, and discussion forums on the internet platform. In order to build a consensus, there will be special techniques of moderation.

The FAMILYPLATFORM will involve a wide range of stakeholders from an early state of the project. The consortium covers well known European experts on applied research for families and family policies in Europe and one important confederation of family organisations in Europe.

Project details

Participants

Result in Brief

• LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE United Kingdom • JYVASKYLAN YLIOPISTO - Suomi/Finland • STAATSINSTITUT FÜR FAMILIENFORSCHUNG AN DER UNIVERSITÄT BAMBERG (IFB) - Deutschland • HUNGARIAN CENTRAL STATISTICAL OFFICE DEMOGRAPHIC RESEARCH INSTITUTE - Magyarorszag • CONFEDERATION DES ORGANISATIONS FAMILIALES DE L’UNION EUROPEENNE - Belgique/België • TALLINN UNIVERSITY - Eesti • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • MOUVEMENT MONDIAL DES MERES - EUROPE - Belgique/België • UNIVERSITAET WIEN - Österreich • FORUM DELLE ASSOCIAZIONI FAMILIARI - Italia • INSTITUTO DE CIENCIAS SOCIAIS DA UNIVERSIDADE DE LISBOA Portugal

Project reference: 243864 Status: Completed Total cost: EUR 1 558 889 EU contribution: EUR 1 398 827 Programme acronym: FP7-SSH Subprogramme area: SSH-2009-3.2.2.

Contract type: Support actions

• New social platform boosts research on families

Report Summary

• Periodic Report Summary - FAMILYPLATFORM (Social platform on research for families and family policies) • Final Report Summary - FAMILYPLATFORM

Documents

• Periodic Report - FAMILYPLATFORM • Final Report - FAMILYPLATFORM

Publications (4)via OpenAIRE

• Social Inequality and Diversity of Families Working Report (April 2010) Wall, Karin, 1955 - Leitão, Mafalda - Ramos, Vasco • Critical Review of Research on Families and Family Policies in Europe Wall, Karin, 1955 - Leitão, Mafalda - Ramos, Vasco • Critical Review of Research on Families and Family Policies in Europe Wall, Karin - Leitão, Mafalda - Ramos, Vasco

Coordinator

TECHNISCHE UNIVERSITAET DORTMUND - Deutschland

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FUSENET

From 2008-10-01 to 2013-09-30 • FUSENET: www.fusenet.eu

Fusenet - the European fusion education network

Objective This aim of the FUSENET project is the establishment of a European Fusion Education Network (FUSENET) for education in fusion science and technology, as part of a comprehensive package of coordination actions, in order to increase, enhance, and broaden fusion training and education activities in Europe. The project consists of eleven focused work packages, with a total proposed budget of 2,000,000. The project brings together a broad representation of the European fusion community with 36 participants from 18 countries, of which 22 Universities and 14 Euratom Associations.

The project consists of four groups of coordination actions: the establishment and running of the FUSENET network; development of individual learning opportunities and common educational goals; development of educational materials and hands-on experiments; and funding of joint educational activities. The FUSENET project will cover all education levels, from secondary school through Bachelor and Master level, to PhD. The actions of

Project details

Project reference: 224982 Status: Completed Total cost: EUR 2 478 290 EU contribution: EUR 1 852 480 Programme acronym: FP7-EURATOM-FUSION Subprogramme area: Fusion-2007-7.1 Contract type: Coordination (or networking) actions

Result in Brief

• Building the next generation of fusion engineers

Report Summary

• Periodic Report Summary 1 - FUSENET (The European fusion education network) • Periodic Report Summary 2 - FUSENET • Periodic Report Summary 3 - FUSENET

Coordinator

TECHNISCHE UNIVERSITEIT EINDHOVEN - Nederland

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FUSENET build upon the already strongly coordinated European Fusion Research programme, coordinated under the European Fusion Development Agreement EFDA. The network will be given a permanent identity by the establishment of the FUSENET Association, which will provide a platform for the coordination of existing actions, the initiation, development and implementation of new EU-wide actions, and for the exchange and dissemination of fusion education information.

The envisioned concrete end result of the FUSENET project is an integrated fusion education system in Europe, with strong links between fusion institutes and higher education institutes. Through a central website, the programme will offer a transparent structure of coherent educational actions, accessible and inviting, in which students and teachers can easily find their way to a variety of attractive ways to participate in the fusion research programme.

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Participants • CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS-CIEMAT - España

• INSTYTUT FIZYKI PLAZMY I LASEROWEJ MIKROSYNTEZY IM. SYLWESTRA KALISKIEGO - Polska

• COMMISSARIAT ENERGIE ATOMIQUE CEA - France

• SZECHENYI ISTVAN UNIVERSITY - Magyarorszag

• CONSIGLIO NAZIONALE DELLE RICERCHE - Italia

• UNIVERSITATEA ALEXANDRU IOAN CUZA - Romania

• ENTE PER LE NUOVE TECNOLOGIE, L’ENERGIA E L’AMBIENTE

• UNIVERZITA KARLOVA V PRAZE AS* - Ceska Republika

Italia • STICHTING VOOR FUNDAMENTEEL ONDERZOEK DER MATERIE FOM - Nederland

• SOFIISKI UNIVERSITET SVETI KLIMENT OHRIDSKI - Bulgaria • MTA KFKI RESZECSKE-ES MAGFIZIKAI KUTATOINTEZET Magyarorszag

• UNIVERSITE HENRI POINCARE NANCY 1 - France

• UNIVERSIDADE TECNICA DE LISBOA - UTL - Portugal

• DANMARKS TEKNISKE UNIVERSITET - Danmark

• UNITED KINGDOM ATOMIC ENERGY AUTHORITY

• UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

United Kingdom

• THE UNIVERSITY OF WARWICK - United Kingdom

• CRANFIELD UNIVERSITY - United Kingdom

• CESKE VYSOKE UCENI TECHNICKE V PRAZE - Ceska Republika

• UNIVERSITÉ DE LORRAINE - France

• QUEEN’S UNIVERSITY BELFAST - United Kingdom

• ARISTOTELIO PANEPISTIMIO THESSALONIKIS - Hellas

• ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Schweiz/Suisse/Svizzera • TAMPEREEN TEKNILLINEN YLIOPISTO - Suomi/Finland • NATIONAL TECHNICAL UNIVERSITY OF ATHENS - Hellas • BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM Magyarorszag • UNIVERSITÉ LIBRE DE BRUXELLES - Belgique/België • UNIVERSITEIT GENT - Belgique/België • UNIVERSITÀ DEGLI STUDI DI PADOVA - Italia • UNIVERSITAET INNSBRUCK - Österreich • FORSCHUNGSZENTRUM JUELICH GMBH - Deutschland • KARLSRUHER INSTITUT FUER TECHNOLOGIE - Deutschland • ECOLE POLYTECHNIQUE - France • ÚSTAV FYZIKY PLAZMATU AV ČR, V. V. I. - Ceska Republika • MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. - Deutschland

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

GEO

From 2012-02-01 to 2016-01-31

Geohazards and geomechanics

Objective This proposal aims to bring together the complementary expertise of world leading groups carrying out research on the engineering assessment, prevention and mitigation of geohazards, the main ones being floods, landslides, and earthquakes considering also the effect of climate change and human activity on soil degradation.

To mitigate these disasters it is necessary to improve our understanding of the failures taking place in flood defence embankments, to have better models for a more rational risk assessment of areas prone to flooding, to investigate the geomechanical conditions leading to the onset of landslides more in depth, to model debris flows and mudflows to estimate run-out distances and destructive power of the landslide materials, etc. In other words, prevention, preparedness and mitigation of geohazards rely on sound geo-engineering which requires competences in geomechanics, numerical modelling, constitutive models for soils, hazard zonation

Project details

Project reference: 294976 Status: Execution Total cost: EUR 438 900 EU contribution: EUR 438 900 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2011-IRSES Contract type: International research staff exchange scheme (IRSES)

Coordinator

THE UNIVERSITY OF WARWICK - United Kingdom

and risk assessment.

The goals of this proposal are: i)To investigate the key aspects of major geohazards (floodings, landslides, earthquakes) to bridge the current gaps in knowledge to improve significantly the current capabilities of prevention, preparedness and mitigation by bringing together specialists engaged in cutting edge research; ii) to enable knowledge exchange among experts in complementary research fields; iii) to train several Early Stage Researches (ESRs) to expand their knowledge during their stay at the host institution; iv) to improve the current normative standards and codes ruling geohazard prevention; v) to generate new approaches to the problems dealt with through exposure to different methodologies.

Participants • UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK - Eire/ireland • UNIVERSITAT POLITECNICA DE CATALUNYA - España • INSTITUT POLYTECHNIQUE DE GRENOBLE - France • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD - United Kingdom • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

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HEM_ID

From 2011-11-01 to 2015-10-31 • www.hemid.eu

HEMatopoietic cell IDentity: genetic and epigenetic regulation in normal and malignant hematopoiesis

Objective In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been well defined in the last years, the precise molecular circuits governing the balance between proliferation/commitment/ specification and how these are corrupted in disease are largely unknown.

The focus of Hem-ID is a highly integrated approach to study the functional interactions between the genetic regulatory circuits orchestrated by transcription factors TFs-, (that direct the progressive cell type specification) and epigenetic mechanisms (that establish the cellular memory that fixes cell fate decisions during differentiation) in physiological hematopoiesis and in leukemia with the final goal of formulating novel diagnostic/prognostic markers

Project details

Project reference: 289611 Status: Execution Total cost: EUR 3 269 702 EU contribution: EUR 3 269 702 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2011-ITN Contract type: Networks for Initial Training (ITN)

Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA, UNIMIB ITALIA PI: Antonella Ronchi, Project Manager: Floriana Di Giacomo

Participants • AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS - España • UNIVERSITÉ JOSEPH FOURIER GRENOBLE 1 - France • BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING - Hellas • INSTITUT CURIE - France • CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH - Österreich • ACADEMISCH ZIEKENHUIS GRONINGEN - Nederland • NERVIANO MEDICAL SCIENCES S.R.L - Italia • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - France • CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE - France • SOURCE BIOSCIENCE PLC - United Kingdom • UNIVERSITÀ DEGLI STUDI DI ROMA LA SAPIENZA - Italia

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and therapeutic approaches in treating leukemias. HEM_ID will: - Decipher Modular Networks assembled by master TFs controlling hematopoietic self renewal and differentiation and the molecular dynamics of TFs/ DNA interactions by unique biophysical approache - Identify epigenetic modifiers (new relevant loci, -epiQTLs, DNAmethylation, Polycomb dependent-gene silencing, miRNA and long non coding RNAs) involved in the pathogenesis of leukemias.

The strength of Hem-ID ITN lies in the high quality multidisciplinary - but strictly integrated - expertise and technological platforms covering the complete pathway from basic research to its clinical exploitation - contributed from both public Institutions and Private sector and made available to Hem-ID Fellows. Besides research, an integrated training program of scientific and complementary activities is offered to HEM-ID Fellows, that will complement and strengthen their career development.

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

The HEM_ID scientific research is articulated into three Sub-programs: Sub-program 1

Transcriptional and epigenetic regulation of hematopoiesis This subprogram focuses on specific aspects of transcriptional and epigenetic regulation of hematopoiesis that include TF function, DNA methylation, histone variants, Polycomb-Group (PcG) proteins and epiQTLs. Specific Projects CeMM, Wien, Austria: TF interactome in hematopoietic stem/progenitor cells. PIs: G. Superti-Furga and F. Grebien. Fellow: Anna Skucha (Poland) UNIMIB, Milano, Italy: Investigating Sox4 and Sox6 function in regulating erythropoiesis. PI: A. Ronchi. Fellow: Isaura Font Monclus (Spain) UJFG, Grenoble France: Potential roles for histone variants H2A.Z and macro H2A in regulating erythropoiesis. PI: S. Dimitrov. Fellow: Ramachandra Boopathi (India) FLEMING, Athens, Greece: Characterization of Dnmt1 DNA methyltransferase interactions with hematopoietic transcription factors in erythroid cells. PI: John Strouboulis. Fellow: Grigosios Tsaknakis (Greece) CSIC, Madrid, Spain: Ring1B PcG protein complexes in hematopoiesis. PI: M. Vidal. Fellow: Katarzyna Starowitz (Poland) UMCG, Groningen, The Netherland: Characterization of genomic regulatory loci (eQTLs) in hematopoietic cell development. PIs: G. de Haan and L. Bystrykh. Fellow: Sara Russo Krauss (Italy).

Sub-program 2

Malignant Hematopoiesis Corruption of physiological regulatory mechanisms controlling cell commitment and differentiation in hematopoiesis, leads to pathological conditions, including leukemia. The aim of this sub-program is to investigate the contribution of specific TFs and miRNAs to the pathogenesis of leukemia.

Projects CeMM, Wien, Austria: TF interactome in hematopoietic stem/progenitor cells. PIs: G. Superti-Furga and F. Grebien. Fellow: Anna Skucha (Poland) UNIMIB, Milano, Italy: Investigating Sox4 and Sox6 function in regulating.

Associated Partner: FT, Fondazione Tettamanti, Ospedale San Gerardo, Italy. FT, working at the interface between research, diagnosis and patients’ social assistance, provides a critical focus on diagnosis/prognosis and socio ethical issues of leukemias. PIs: Andrea Biondi, Gianni CazzanigaUNIMIB, Milano, Italy: Investigating Sox4 and Sox6 function in regulating.

Sub-program 3

Horizontal technological platforms and support activities This Subprogram is dedicated to develop and enhance common methodological approaches and technology platforms (massive parallel sequencing, siRNA knockdowns, Transcription Factors-DNA interactions assays) used

by HEMID Partners.

NMS, Nerviano, Italy: siRNA validation of novel targets relevant to hemato-oncogenesis. PI: F. Gasparri.Fellow: Marta Durlak (Poland) CNRS, Lyon, France: Dynamics of TF chromatin interactions at a millisecond time scale and at one base pair resolution. PI: D. Angelov. Fellow: Ognyan Svetlenov Tonchev (Bulgary). SourceBioscience, Nottingham, UK: Bioinformatics and database development for the analysis of massive parallel sequence datasets. PI: T. Burr. Fellow: Robert Steinfelder (Germany).

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HOLMES

From 2014-02-01 to 2019-01-31

The Electron Capture Decay of 163Ho to Measure the Electron Neutrino Mass with sub-eV sensitivity

Objective HOLMES is aimed at directly measuring the electron neutrino mass using the electron capture (EC) decay of 163Ho. The measurement of the absolute neutrino mass represents a major breakthrough in particle physics and cosmology. Due to their abundance as big-bang relics, massive neutrinos strongly affect the large-scale structure and dynamics of the universe. In addition, the knowledge of the scale of neutrino masses, together with their hierarchy pattern, is invaluable to clarify the origin of fermion masses beyond the Higgs mechanism.

The innovative approach of HOLMES consists in the calorimetric measurement of the energy released in the decay of 163Ho. In this way, all the atomic de-excitation energy is measured, except that carried away by the neutrino. A finite neutrino mass m causes a deformation of the energy spectrum which is truncated at Q-m, where Q is the EC transition energy. The sensitivity depends on Q - the lower the Q, the higher the sensitivity - and 163Ho is an ideal isotope with a Q around 2.5keV. The

Project details

Project reference: 340321 Status: Accepted Total cost: EUR 3 057 067 EU contribution: EUR 3 057 067 Programme acronym: FP7-IDEAS-ERC Subprogramme area: ERC-AG-PE2 Contract type: ERC Advanced Grant

Principal Investigator Prof. Stefano Ragazzi

Host Institution

ISTITUTO NAZIONALE DI FISICA NUCLEARE - Italia

Beneficiaries

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia ISTITUTO NAZIONALE DI FISICA NUCLEARE - Italia

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direct measurement exploits only energy and momentum conservation, and it is therefore completely model-independent. At the same time, the calorimetric measurement eliminates systematic uncertainties arising from the use of external beta sources, as in neutrino mass measurements with beta spectrometers, and minimizes the effect of the atomic de-excitation process uncertainties.

HOLMES will deploy a large array of low temperature microcalorimeters with implanted 163Ho nuclei. The resulting mass sensitivity will be as low as 0.4eV. HOLMES will be an important step forward in the direct neutrino mass measurement with a calorimetric approach as an alternative to spectrometry. It will also establish the potential of this approach to extend the sensitivity down to 0.1eV. The detection techniques developed for HOLMES will have an impact in many frontier fields as astrophysics, material analysis, nuclear safety, archeometry, quantum communication.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

IMAGE DDR

From 2008-11-01 to 2012-10-31

High resolution microscopy in the DNA damage response

Objective Background: The DNA damage response (DDR) is a specialised stress response fundamental to maintaining genome integrity and suppressing tumour formation. Traditional molecular and cellular biology, combined with genetics and biochemistry, have led to an understanding of the architecture of the DDR in a variety of model organisms and in human cells. These studies have employed populations of cells/molecules and their results are of necessity an average of the response. High sensitivity imaging technologies make it feasible to study events in single cells and to do experiments with small numbers of molecules in vitro.

Project Objectives: To provide an interdisciplinary training in single cell and single molecule studies to graduate students in Physics, Chemistry, LS, Maths and Computer sciences. The focus of the research will be the study of the DDR and genome stability. The main technologies to be developed concern high resolution molecular imaging methodologies.

Specific aims: To train eight early stage researchers to doctoral level to utilize an interdisciplinary approach to address specific scientific questions and to communicate between disciplines. Study Design: We will achieve our objective by building a network comprising four local groups, each a collaboration between an imaging specialist and a cell biologist / molecular geneticists engaged in research on genome stability.

The collaborating scientists will serve as co-advisors and will develop a personalised interdisciplinary research training programme for each recruit. Local training will be augmented by specially designed network-wide summer schools, workshops and meetings encompassing all network participants and invited experts. An industrial partner is integral to the network in order to share methods and provide secondments and input into workshops to train researchers in technology exploitation.

Publications

Project details

• Nestoras, K., Mohammed, A.H., Schreurs, A.S., Fleck, O., Watson, A.T., Poitelea, M., O’Shea, C., Chahwan, C., Holmberg, C., Kragelund, B.B., Nielsen, O., Osborne, M., Carr, A.M. and Liu, C. (2010) Regulation of Ribonucleotide Reductase by Spd1 involves multiple mechanisms. Genes Dev: 24:1145-1159.

• Bonetti D, Clerici M, Anbalagan S, Martina M, Lucchini G, Longhese MP (2010) Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres. PLoS Genet. 6: e1000966.

• Anbalagan S, Bonetti D, Lucchini G, Longhese MP (2011) Rif1 supports the function of the CST complex in yeast telomere capping. PLoS Genet. 7: e1002024.

• Longhese MP, Anbalagan S, Martina M, Bonetti D (2012) The role of shelterin in maintaining telomere integrity. Front. Biosci. 2012 17:1715-28.

• Iraqui I, Chekkal Y, Jmari N, Pietrobon V, Fréon K, Costes A, Lambert SA (2012) Recovery of arrested replication forks by homologous recombination is error-prone. PLoS Genet 8:e1002976.

• Hegnauer, A.M., Hustedt, N., Shimada, K., Pike, B.L., Vogel, M., Amsler1, P., Rubin, S.M., van Leeuwen, F., Guenole, A., van Attikum H., Thoma, N. H. and Gasser, S.M. (2012) An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks. EMBO J 31; 3768-3783.

• Lavut A, Raveh D (2012) Sequestration of Highly Expressed mRNAs in Cytoplasmic Granules, P-Bodies, and Stress Granules Enhances Cell Viability. PLoS Genet 8: e1002527.

• Voloshin O, Bakhrat A, Herrmann S, Raveh D (2012) Transfer of Ho Endonuclease and Ufo1 to the Proteasome by the UbL-UbA Shuttle Protein, Ddi1, Analysed by Complex Formation In Vitro. PLoS ONE 7: e39210.

• Hustedt N, Gasser SM, Shimada K (2013) Replication checkpoint: tuning and coordination of replication forks in S phase. Genes (Basel) 4:388-434.

• Bonetti D, Anbalagan S, Lucchini G, Clerici M, Longhese MP (2013) he Tbf1 and Vid22 proteins promote resection and non-homologous end joining at DNA double-strand break ends. EMBO J. 32:275-89.

Project reference: 215148 Status: Completed Total cost: EUR 2 160 000 EU contribution: EUR 2 160 000 Programme acronym: FP7-PEOPLE Subprogramme area: PEOPLE-2007-1-1-ITN Contract type: Networks for Initial Training (ITN)

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • INSTITUT CURIE - France • NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER-INSTITUT FOR BIOMEDICAL RESEARC Schweiz/Suisse/Svizzera • BEN-GURION UNIVERSITY OF THE NEGEV - Israel • GENOMIC VISION - France

Coordinator

UNIVERSITY OF SUSSEX - United Kingdom

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IMODE-CKD

From 2013-09-01 to 2017-08-31 • IMODE-CKD: www.imodeckd.org

Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease

Objective iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical research. This educational scope is placed in the context of a significant research objective: to improve quality of life of patients with chronic kidney disease (CKD) and diminish the severe health and economic burden imposed by this disease, by providing better diagnostic and prognostic means. Established CKD has been selected based on the accumulation of existing molecular data, and complementarity to active European programs focusing on early stage CKD in the context of diabetes and hypertension, in which participants of the consortium are actively involved. The main objectives of iMODE-CKD are: - Training young scientists to become the next generation of true transla-

Project details

Project reference: 608332 Status: Execution Total cost: EUR 2 794 789 EU contribution: EUR 2 794 789 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2013-ITN Contract type: Networks for Initial Training (ITN)

Coordinator

BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS Hellas

tional multidisciplinary researchers exploiting multiple -omics technologies to their full extent.

- Training young scientists in Systems Biology approaches to decipher molecular pathology and understanding clinical phenotypes.

- Identifying and validating molecules involved in progression of renal complications trough clinical –omics in established CKD. - Understanding the molecular determinants of established CKD through integrative Systems Biology. iMODE-CKD provides the opportunity to train young researchers not only in the different fields of -omics research, but also in -omics data evaluation, combining of datasets from different -omics traits, and exploiting both, data and literature, to enable the generation of in silico models of the molecular pathology of specific diseases. Such approaches will also enable development of new and specific drugs; and pave the road towards stratified/personalized medicine.

Participants • • • •

• • • •

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SERVICEXS BV - Nederland UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia CHARITE - UNIVERSITAETSMEDIZIN BERLIN - Deutschland HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH - Deutschland MOSAIQUES DIAGNOSTICS GMBH - Deutschland INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE (INSERM) - France UNIVERSITY OF GLASGOW - United Kingdom SS. CYRIL AND METHODIUS UNIVERSITY IN SKOPJE The former yugoslav Republic of Macedonia

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

IMPACT EUROPE

From 2014-01-01 to 2017-06-30

Innovative Method and Procedure to Assess Counter-violent-radicalisation Techniques in Europe

Objective IMPACT Europe will develop an evaluation toolkit to help professionals in the public and voluntary sectors design and implement an evaluation of their programmes tackling violent radicalisation, whether policies or interventions.

The toolkit will also help professionals go beyond the evaluation of a single project by integrating best practice into the design and implementation of future programmes.

This evaluation toolkit will be composed of four elements: 1) A standardised methodology, to provide professionals with a tool to con-

Project details

Project reference: 312235 Status: Accepted Total cost: EUR 3 534 308 EU contribution: EUR 2 801 537 Programme acronym: FP7-SECURITY Subprogramme area: SEC-2012.6.1-1 Contract type: Small or medium-scale focused research project

Coordinator

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO - Nederland

duct robust evaluations; 2) An evaluation results database, to allow professionals to analyse these results over time, identify best practice and develop a more informed understanding of violent radicalisation; 3) A training course (including a train-the-trainer component), to build professionals’ capacity to design, carry out and learn from appropriate evaluations; 4) A training manual, to provide easy reference for professionals applying the toolkit.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • ITTI SP ZOO - Polska • RAND EUROPE COMMUNITY INTEREST COMPANY United Kingdom • STICHTING HOGESCHOOL UTRECHT - Nederland • ISC INTELLIGENCE IN SCIENCE SPRL - Belgique/België • STICHTING DR HILDA VERWEY-JONKER INSTITUUT - Nederland • CEVAS DI LEONE LILIANA - Italia • FONDATION POUR LA RECHERCHE STRATEGIQUE - France • POLITIEREGIO ZAANSTREEK-WATERLAND - Nederland • RADICAL MIDDLE WAY COMMUNITY INTEREST COMPANY United Kingdom • INTERNATIONAL SECURITY AND COUNTER-TERRORISM ACADEMY - Israel

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IMPRESSIONS

From 2013-11-01 to 2018-10-31 • IMPRESSIONS: impressions-project.eu

Impacts and risks from higher-end scenarios: Strategies for innovative solutions

Objective IMPRESSIONS will provide empirically-grounded, transformative science that quantifies and explains the consequences of high-end climate scenarios for both decision-makers and society. IMPRESSIONS will develop and apply a novel participatory methodology that explicitly deals with uncertainties and strong non-linear changes focussing on high-end climate change, but also including intermediate warming levels. This new methodology will build on the representative concentration pathways (RCPs) and shared socio-economic pathways (SSPs) to create a coherent set of highend climate and socio-economic scenarios covering multiple scales. These scenarios will be applied to a range of impact, adaptation and vulnerability models that build on theories of complex systems and address tipping elements as key characteristics of such systems. The models will be embedded within an innovative multi-scale integrated assessment approach to improve analysis of cross-scale interactions and cross-sectoral benefits,

Project details

Project reference: 603416 Status: Execution Total cost: EUR 11 248 478 EU contribution: EUR 8 914 935 Programme acronym: FP7-ENVIRONMENT Subprogramme area: ENV.2013.6.1-3 Contract type: Collaborative project (generic)

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD - United Kingdom

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conflicts and trade-offs. Model results will inform the development of timeand path-dependent transition pathways. These will include mechanisms to foster synergies between adaptation and mitigation and will aim to build resilience in the face of uncertainty. Methods will be applied within five linked multi-sectoral case studies at global, European and regional/local scales. Stakeholders within these case studies will be fully engaged in the research process through a series of in-depth professionally facilitated workshops which maximise their active participation in defining high-end scenarios and adaptation and mitigation pathways, and in analysing the inherent risks and opportunities of new policy strategies. This will build the capacity of stakeholders to understand the risks, opportunities, costs and benefits associated with different adaptation and mitigation pathways under high-end scenarios, and how they might be effectively embedded within decision-making processes.

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Participants • LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE United Kingdom

MEDIU, AGRICULTURA SI SCHIMBARI GLOBALE - Romania • WAGENINGEN UNIVERSITY - Nederland

• UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

• DUTCH RESEARCH INSTITUTE FOR TRANSITIONS BV - Nederland

• SCUOLA SUPERIORE DI STUDI UNIVERSITARI

• KOZEP-EUROPAI EGYETEM - Magyarorszag

E DI PERFEZIONAMENTO SANT’ANNA - Italia • THE UNIVERSITY OF EDINBURGH - United Kingdom • UNIVERSITAET KASSEL - Deutschland • IODINE SPRL - Belgique/België

• FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA - Portugal • POTSDAM INSTITUT FUER KLIMAFOLGENFORSCHUNG Deutschland

• CRANFIELD UNIVERSITY - United Kingdom • DANMARKS METEOROLOGISKE INSTITUT - Danmark • STIFTELSEN THE STOCKHOLM ENVIRONMENT INSTITUTE Sverige • PROSPEX BVBA - Belgique/België • PARIS-LODRON-UNIVERSITÃT SALZBURG - Österreich • JOAN DAVID TABARA VILLALBA - España • PENSOFT PUBLISHERS LTD - Bulgaria • JAGER JILL - Österreich • EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH Schweiz/Suisse/Svizzera • SUOMEN YMPARISTOKESKUS - Suomi/Finland • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - France • FUNDATIA PENTRU TEHNOLOGIA INFORMATIEI APLICATE IN

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

LENVIS

From 2008-09-01 to 2012-01-31 • LENVIS: www.lenvis.eu

Localised environmental and health information services for all: User-centric collaborative decision support network for water and air quality management

Objective The main goal of the LENVIS project is to develop an innovative collaborative decision support network for exchange of location-based environmental and health services between all stakeholders, for enhanced capacity to assess population exposure and health risks and better management of the concerned ecosystems. LENVIS will include health indicators as integral part of the environmental management.

There is a growing demand for real time and integrated environmental and health risk information. Provision of such location-based services linked to the state of the environment at particular geographical locations (addresses) is necessary for improving the quality of life of all people.

This is essential for mitigation of environmental-related health threats associated to water quantity and quality, and outdoor air pollutions.

Project details

Project reference: 223925 Status: Completed Total cost: EUR 3 131 818 EU contribution: EUR 2 232 223 Programme acronym: FP7-ICT Subprogramme area: ICT-2007.6.3 Contract type: Collaborative project (generic)

Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

LENVIS project aims to fill the existing gap between environmental management and the health management systems. This will be done by developing a generic ICT solution that combines service-oriented-architecture (SOA) and user-centric approach (peer-to-peer network, P2P) by fusion of location-based environmental and health data, information and modelling services. This novel collaborative peer-to-peer network, as an integral part of the Single Information Space for the Environment in Europe, will be validated through test cases on fresh surface water and outdoor air quality in the Netherlands, Portugal and Italy. LENVIS project will facilitate collaboration between different stakeholders, such as environmental protection agencies, health institutions and service providers, policy makers, citizens in general and environmental communities in Europe.

Participants • INSTITUTO SUPERIOR TECNICO - Portugal • ARIA TECHNOLOGIES SA - France • COMUNE DI BARI - Italia • HYDROLOGIC BV - Nederland • NOORD-BRABANT PROVINCIE - Nederland • UNESCO-IHE INSTITUTE FOR WATER EDUCATION - Nederland • ESAPROJEKT SP Z OO - Polska • GMVIS SKYSOFT SA - Portugal • HIDROMOD MODELACAO EM ENGENHARIA LDA - Portugal

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MEETMETONIGHT

From 2012-04-01 to 2012-10-31

MEET RESEARCHERS TONIGHT!

Objective In the context of one of the most powerful and rich economic areas of Europe, Milan and Lombardy Region, MEETmeTONIGHT was born as an initiative of Politecnico di Milano together with the main city universities and for the first time is extended to the entire Regional territory. The project will involve 3 full partners and, as associated partners, a long and various list of public and private entities (all main Milan universities, Lombardy Region Government, Province of Milan, Municipality of Milan, foundations, associations and media partners). The concept of the overall project is to enhance the awareness among the citizens that universities, science and research represent nowadays the future of the whole society and its main actors, that is to say the Researchers, will impact with their job on competitiveness, economic growth, employment, environmental protection and in general on citizens daily life.

Therefore it aims at: a) showing to common people the normality of the daily

Project details

Project reference: 316552 Status: Completed Total cost: EUR 198 951 EU contribution: EUR 100 000 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2012-NIGHT Contract type: Support actions

Coordinator

POLITECNICO DI MILANO - Italia

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Researchers life; b) amplifying the social image of Researchers; c) opening up consciousness about the importance of a scientific career in the local, national and European context; d) launching the first Lombardy Researchers Night as a distinctive date to be attended every year, so to foster the liaison between Researchers and citizens. The practical aim of the project is to organise an outstanding evening where people will have the opportunity to meet and know the Researchers directly. MEETmeTONIGHT wants to communicate the message: Researchers are people like you! Meet me and see what I do everyday. The central locations of the event (in the Milan city centre) will encourage the involvement of a large number of people. Simultaneously on all Lombardy campuses of the University partners and on locations of associated partners (Como, Lecco, Ispra, Brescia, Mantova, Cremona, Pavia, Lodi) satellite events will take place.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • UNIVERSITÀ DEGLI STUDI DI MILANO - Italia

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

MEUSIX

From 2012-12-01 to 2017-11-30 • MEUSIX: meusix.tigem.it

Clinical trial of gene therapy for MPS VI - a severe lysosomal storage disorder

Objective Mucopolysaccharidosis VI (MPS VI, or Maroteaux-Lamy syndrome; OMIM #253200) is a rare lysosomal storage disease caused by deficient activity of arylsulfatase B (ARSB). MPS VI is characterized by growth retardation, corneal clouding, cardiac valve disease, organomegaly, skeletal dysplasia, without central nervous system involvement. Thus, systemic therapies targeting peripheral organs have the potential to fully correct the MPS VI phenotype. Enzyme replacement therapy, the current treatment for MPS VI, requires weekly infusions of a costly enzyme and has limited efficacy on bone and corneal disease. Based on the encouraging preclinical results generated by our group, gene therapy based on a single intravascular administration of adeno-associated viral (AAV) vectors targeting liver

Project details

Project reference: 304999 Status: Execution Total cost: EUR 7 877 621 EU contribution: EUR 5 995 041 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH.2012.2.4.4-1 Contract type: Small or medium-scale focused research project

Coordinator

FONDAZIONE TELETHON - Italia

has the potential to provide a lifelong source of ARSB. The MeuSIX consortium plans to conduct a multicenter phase 1/2 clinical trial to investigate the safety and efficacy of AAV-mediated gene therapy in patients with MPS VI. An orphan drug designation (ODD) has been obtained from both the European Medicinal Agency and the US Food and Drug Administration for the MPS VI therapeutic AAV vector. The results from this clinical trial proposed by the MeuSIX consortium has the potential to have a tremendous impact on the natural history of MPSVI and to significantly improve the quality of life of the affected patients. Moreover, the approach developed may facilitate the development of similar approaches for other inborn errors of metabolism.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Nederland • HACETTEPE UNIVERSITESI - Turkey • INFORMA SRL - Italia • REGENX BIOSCIENCES LLC - United States • UNIVERSITÀ DEGLI STUDI DI NAPOLI FEDERICO II - Italia • GENOSAFE SAS - France

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MIME

From 2014-03-01 to 2018-08-31

MOBILITY AND INCLUSION IN MULTILINGUAL EUROPE

Objective Using an innovative interdisciplinary approach, MIME will generate an organised body of policy-relevant propositions addressing the full range of questions raised in the call. Our aim is to identify the language policies and strategies that best combine “mobility” and “inclusion”.

MIME emphasises complementarity between disciplines, and brings together researchers from sociolinguistics, political science, sociology, history, geography, economics, education, translation studies, psychology, and law, who all have longstanding experience in the application of their discipline to language issues. The diverse concepts and methods are combined in an analytical framework designed to ensure their practice-oriented integration. MIME identifies, assesses and recommends measures for the management of trade-offs between the potentially conflicting goals of mobility and inclusion in a multilingual Europe. Rather than taking existing trade-offs as a given, we think that they can be modified, both in symbolic and in material/financial

terms, and we argue that this objective can best be achieved through carefully designed public policies and the intelligent use of dynamics in civil society.

Several partners have been involved in successful FP6 research, and key advances achieved there will guide the MIME project: languages are viewed as fluid realities in a context of high mobility of people, goods, services, and knowledge, influencing the way in which skills and identities are used and constantly re-shaped. The project integrates these micro-level insights into a macro-level approach to multilingual Europe.

MIME results will be made widely available through a creative approach to dissemination, including training modules and the MIME Stakeholder Forum, allowing for sustained dialogue between academics, professional associations and local/regional authorities. The project culminates in a consensus conference where recommendations based on the project findings are adopted.

Project details

Project reference: 613344 Status: Accepted Total cost: EUR 6 392 523 EU contribution: EUR 4 999 998 Programme acronym: FP7-SSH Subprogramme area: SSH.2013.5.2-1 Contract type: Large-scale integrating project

Coordinator

UNIVERSITÉ DE GENEVE - Schweiz/Suisse/Svizzera

Participants • • • • • • • • • • • • • • • • •

SCIPROM SARL - Schweiz/Suisse/Svizzera FONDATION NATIONALE DES SCIENCES POLITIQUES - France LATVIJAS UNIVERSITATE - Latvija KATHOLIEKE UNIVERSITEIT LEUVEN - Belgique/België UNIVERZA V LJUBLJANI - Slovenija UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia UNIVERSITAET AUGSBURG - Deutschland VRIJE UNIVERSITEIT BRUSSEL - Belgique/België UNIVERSITEIT VAN AMSTERDAM - Nederland THE UNIVERSITY OF EDINBURGH - United Kingdom UNIVERSITAET LEIPZIG - Deutschland UPPSALA UNIVERSITET - Sverige UNIVERSITAT ROVIRA I VIRGILI - España UNIVERSITÉ DE REIMS CHAMPAGNE-ARDENNE - France HUMBOLDT-UNIVERSITAT ZU BERLIN - Deutschland UNIVERSITY OF LIMERICK - Éire/Ireland SVEUCILISTE JOSIPA JURJA STROSSMAYERA U OSIJEKU FILOZOFSKI FAKULTET - Hrvatska • FONDATION OBSERVATOIRE DE LA FINANCE Schweiz/Suisse/Svizzera • UNIVERSITATEA DIN ORADEA - Romania • UNIVERSIDADE DO ALGARVE - Portugal

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• MAGYAR TUDOMANYOS AKADEMIA TARSADALOMTUDOMANYI KUTATOKOZPONT - Magyarorszag

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

NAD

From 2008-09-01 to 2013-08-31 • NAD: www.nadproject.eu

Nanoparticles for therapy and diagnosis of Alzheimer disease

Objective The search for effective therapies and early detection strategies for Alzheimer

Project details

Project reference: 212043 Status: Execution Total cost: EUR 14 365 090 EU contribution: EUR 10 921 350 Programme acronym: FP7-NMP Subprogramme area: NMP-2007-4.0-4 Contract type: Large-scale integrating project

Result in Brief

• Nanoparticles for treating Alzheimer’s disease

Report Summary

• Periodic Report Summary 2 - NAD (NANOPARTICLES FOR THERAPY AND DIAGNOSIS OF ALZHEIMER DISEASE) • Periodic Report Summary 1 - NAD

Documents

• Periodic Report - NAD

Publications (39)via OpenAIRE

• Nonfibrillar Abeta(1-42) Inhibits Glutamate Uptake and Phosphorylates p38 in Human Fibroblasts Chiara Paola Zoia - Chiara Riva - Valeria Isella - Paola Proserpio - Alessandro Terruzzi - Silvia Arban - Domenico Salerno - Valeria Cassina - Francesco Mantegazza - Lucio Tremolizzo - Carlo Ferrarese • Tetracycline prevents A beta oligomer toxicity through an atypical supramolecular interaction Cristina Airoldi - Laura Colombo - Claudia Manzoni - Erika Sironi Antonino Natalello - Silvia Maria Doglia - Gianluigi Forloni - Fabrizio Tagliavini - Elena Del Favero - Laura Cantu - Francesco Nicotra Mario Salmona • Disturbed Ca2+ homeostasis increases glutaminyl cyclase expression; connecting two early pathogenic events in Alzheimer’s disease in vitro.

Line De Kimpe - Anna Bennis - Rob Zwart - Elise S van Haastert Jeroen J M Hoozemans - Wiep Scheper

Participants • • • • • • • • • • • • • • • • • •

LANCASTER UNIVERSITY - United Kingdom BIOTALENTUM TUDASFEJLESZTO KFT - Magyarorszag UNIVERSITÉ PARIS-SUD XI - France CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED - Slovenska Republika UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA - España TURUN YLIOPISTO - Suomi/Finland KAROLINSKA INSTITUTET - Sverige BIAL INDUSTRIAL FARMACEUTICA S.A. - España STAB VIDA, INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA. - Portugal CENTRO DE INVESTIGACION BIOMEDICA EN RED ENFERMEDADES NEURODEGENERATIVAS - España ISTITUTO DI RICERCHE FARMACOLOGICHE - Italia ACADEMISCH MEDISCH CENTRUM - Nederland KØBENHAVNS UNIVERSITET - Danmark UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 - France GUERBET SA - France NANOVECTOR SRL - Italia UNIVERSITY OF PATRAS - Hellas UNIVERSITEIT ANTWERPEN - Belgique/België

Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

NEMO

From 2009-05-01 to 2013-04-30 • NEMO: nemo.vtt.fi

Novel high-performance enzymes and micro-organisms for conversion of lignocellulosic biomass to bioethanol

Objective The NEMO project provides novel efficient enzymes and microbes for 2nd generation bioethanol production. It generates through metabolic engineering and mutagenesis & screening approaches robust yeast strains that have a broad substrate range and can (co-)ferment C6 and C5 sugars to ethanol with high productivity (rate and yield), and that are significantly more stress tolerant, i.e. inhibitor, ethanol and thermotolerant than the current S.cerevisiae strains used in ethanol production.

The NEMO project also identifies and improves enzymes for hydrolysis of biomasses relevant for Europe. Novel enzymes are identified and improved through various approaches, based on screening, broad comparative genomics analyses, and protein engineering. These efforts will generate more thermostable enzymes for high temperature hydrolysis, more efficient enzymes for hydrolysis of the resistant structures in lignocellulose such as crystalline cellulose and lignin-hemicellulose complexes, enzymes with reduced affinity

on lignin, and efficient thermo and mesophilic enzyme mixtures that are optimised and tailor-made for the relevant biomasses for Europe and European industry. These novel biocatalysts are tested in an iterative manner in process relevant conditions, including also pilot-scale operations, which ensure that the novel enzymes and microbes will be superior in real process conditions.

Furthermore, optimal enzyme, microbe and process regime combinations are identified, providing basis for the development of the most economic and ecoefficient overall processes. The impact of the NEMO project on 2nd generation bioethanol production is significant because it provides most realistic but widely applicable technologies that could be exploited broadly by European industry. Its impact goes also much beyond bioethanol because NEMO provides technology improvements that are directly applicable and crucial for efficient and economic production of also other biofuels and bulk chemicals.

Project details

Project reference: 222699 Status: Completed Total cost: EUR 8 098 596 EU contribution: EUR 5 898 000 Programme acronym: FP7-KBBE Subprogramme area: KBBE-2007-3-2-06 Contract type: Large-scale integrating project

Coordinator

TEKNOLOGIAN TUTKIMUSKESKUS VTT - Suomi/Finland

Participants • • • • • • • • • • • • • • • • • •

UNIVERZA V LJUBLJANI - Slovenija LUNDS UNIVERSITET - Sverige UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Schweiz/Suisse/Svizzera UNIVERSITEIT UTRECHT - Nederland HELSINGIN YLIOPISTO - Suomi/Finland CHALMERS TEKNISKA HOEGSKOLA AB - Sverige WIRTSCHAFT UND INFRASTRUKTUR GMBH & CO PLANUNGS KG Deutschland DYADIC NEDERLAND BV - Nederland ROAL OY - Suomi/Finland KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN – KNAW - Nederland SEKAB E-TECHNOLOGY AB - Sverige VIB - Belgique/België UNIVERSITÉ DE LA MEDITERRANEE D’AIX-MARSEILLE II - France C-LECTA GMBH - Deutschland GREEN SUGAR GMBH PRODUKTINNOVATIONEN AUS BIOMASSE Deutschland JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN - Deutschland UNIVERSITÉ D’AIX MARSEILLE - France

• SYNGENTA CROP PROTECTION AG - Schweiz/Suisse/Svizzera • CHEMTEX ITALIA SRL - Italia

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ODMIR

From 2009-12-01 to 2014-11-30

The origins and development of the human mirror neuron system

Objective Evidence demonstrating the presence of mirror neurons in the adult human brain has led many researchers to suggest a fundamental role for the mirror neuron system (MNS) in human mentalizing behaviour and social cognition. Recent findings have also suggested strong relationships between MNS impairments and neurodevelopmental disorders in which mentalizing behaviour is impaired. In light of this evidence, it has become of paramount importance to understand whether or not the MNS is present at birth and how its functional properties develop throughout infancy. The current project will address these questions within the text of a neurostructivist framework, according to which a basic perception-action coupling mechanism would be present from birth, and

Project details

Project reference: 241176 Status: Execution Total cost: EUR 1 208 400 EU contribution: EUR 1 208 400 Programme acronym: FP7-IDEAS-ERC Subprogramme area: ERC-SG-SH4 Contract type: ERC Starting Grant

Principal Investigator Dr. Chiara Turati

Host Institution

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

Beneficiaries

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

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undergoes a series of refinements through experience and visuomotor learning. Using behavioural, electromyographic and electrophysiological measures, the project aims to investigate action understanding and emotion recognition in newborns and infants. Behavioural looking time and eye-movement paradigms will be used to test infants ability to visually anticipate the actions goal. Electromyographic paradigms will allow for testing of when and how the activation of infants muscles is affected by the goal of the observed action or the emotion expressed by the observed face. Electrophysiological paradigms will be used to investigate modulations of infants EEG activity during the execution and observation of grasping actions.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

PICOSEC-MCNET

From 2011-12-01 to 2015-11-30 • PICOSEC-MCNET: picosec.web.cern.ch

Pico-second Silicon photomultiplier-Electronics- & Crystal research-Marie-Curie-Network

Objective We propose to establish a special detector-training network aiming to extend the application of cutting-edge technologies developed in High Energy Physics (HEP) to other domains, such as medical imaging. A large number of detector techniques, developed for and used in particle physics experiments, has been transferred successfully to other fields. Most prominent are their applications in medicine, X-ray imaging, materials research, astrophysics and others. These technological spin-offs are of highest value for society and will be a focal point in this Network. Not only for positron emission tomography (PET), the Network will likewise respond to the need to develop new ultra-fast photo-detection for the future generation of linear colliders with unprecedented beam intensities. The Multi-Site Network, to be coordinated by CERN, would be an interdisciplinary, multi-national initiative whose main goal is to train young researchers in the domain of novel high-speed photo-detec-

Project details

Project reference: 289355 Status: Execution Total cost: EUR 5 699 664 EU contribution: EUR 5 699 664 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2011-ITN Contract type: Networks for Initial Training (ITN)

Coordinator

EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH Schweiz/Suisse/Svizzera

tion instruments in HEP calorimetry and also to make use of photon time of flight (TOF) in PET, thus enabling us for the first time to considerably enhance image quality with instant benefits to patients and medical institutions. This multi-site ITN comprises 11 full partners, 7 in academia and 4 in the private sector, known world-wide in the fields of frontier detector technologies, photo detection techniques and novel scintillator production methods, as well as in the domain of semiconductor technology, medical instrumentation, image reconstruction and fusion, and surgical tracking and navigation. As such, the Network combines the necessary competence, expertise and infrastructure for top-level training of young researchers. It is foreseen to hire 18 Early Stage Researchers (ESRs) plus 4 Experienced Researchers (ERs) and structure the training project into five principle research-oriented work packages, and three work package for management, training and outreach.

Participants • LABORATORIO DE INSTRUMENTACAO E FISICA EXPERIMENTAL DE PARTICULAS - Portugal • TECHNISCHE UNIVERSITEIT DELFT - Nederland • RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG - Deutschland • TECHNISCHE UNIVERSITAET MUENCHEN - Deutschland • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • STMICROELECTRONICS SRL - Italia • STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY Deutschland • FIBERCRYST SAS - France • KLOE SA - France • SURGICEYE GMBH - Deutschland

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PINCETTE

From 2010-07-01 to 2013-06-30 • PINCETTE: www.pincette-project.eu

Validating Changes and Upgrades in Networked Software

Objective Europe relies on the availability and flawless functioning of distributed infrastructures, such as electricity, water, communication, transportation, and environmental management. This infrastructure is based on distributed networked IT systems for monitoring and control.

Technological innovation offers opportunities for more efficient infrastructure.

Innovation in infrastructures and the resulting improvement in quality of life are hindered by the danger of upgrades: • in a new version, some of the existing functionality can be lost; • incompatibilities between the old and new version can result in major service outages; As it is infeasible to update the entire infrastructure at once, periods of coexistence between old and new components are inevitable.

As a result, infrastructure upgrades are done only once the existing infrastructure performs below acceptable levels. Lowering the risk of infrastructure updates will benefit society, infrastructure operators, and the European systems vendors. All existing validation solutions do not take upgrades into account. A solution for validating upgrades is in dire need

Project details

Project reference: 257647 Status: Execution Total cost: EUR 4 173 406 EU contribution: EUR 2 800 000 Programme acronym: FP7-ICT Subprogramme area: ICT-2009.1.4 Contract type: Collaborative project (generic)

Publications (7)via OpenAIRE

• Dynamic Analysis of Upgrades in C/C++ Software PASTORE, FABRIZIO - MARIANI, LEONARDO • Revolution: Automatic Evolution of Mined Specifications MARIANI, LEONARDO • PINCETTE - Validating Changes and Upgrades in Networked Software MARIANI, LEONARDO - DENARO, GIOVANNI

Coordinator

IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD - Israel

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because of shorter product lifecycles and increasing complexity and scale of networked systems.

PINCETTE will develop the technology to ensure safe infrastructure upgrades by validating continuously evolving networked software systems.

PINCETTE will 1) reduce the cost and time to market of upgrades by several orders of magnitude; 2) increase the level of confidence in the safety of upgrades; 3) enable certification of upgrades.

The PINCETTE consortium is composed of the leading European research experts and prominent infrastructure providers. The PINCETTE technology will be validated at: • ABB produces and sells components and systems used in utility, industrial, and public transportation infrastructures. A major share of the European power grid is built on ABB equipment.

• VTT provides the monitoring and maintenance robot system for the International Thermonuclear Experimental Reactor.

• IAI operates autonomous aircrafts for environmental monitoring, deployed worldwide.

Participants • UNIVERSITÀ DELLA SVIZZERA ITALIANA - Schweiz/Suisse/Svizzera • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD - United Kingdom • ABB SCHWEIZ AG - Schweiz/Suisse/Svizzera • TEKNOLOGIAN TUTKIMUSKESKUS VTT - Suomi/Finland • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • ISRAEL AEROSPACE INDUSTRIES LTD - Israel

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

PRAGES

From 2008-04-01 to 2009-12-31 • PRAGES: www.pragesdatabase.eu

Practising gender equality in science

Objective The project Practising Gender Equality in Science (PRAGES) consists of an action of coordination aimed at comparing the various strategies implemented for promoting the presence of women in decision-making bodies relating to scientific research in public institutions. It pursues the objective of collecting, classifying and evaluating good practices and positive actions (involving those where a positive contribution from men is recorded) that can be found in OECD countries, both at the national level and at the level of the individual institutions, and to make them available, in a usable form, to a number of selected targets, including both decision-makers and other

Project details

Project reference: 217754 Status: Completed Total cost: EUR 1 498 040 EU contribution: EUR 998 418 Programme acronym: FP7-SIS Subprogramme area: SiS-2007-2.1.1.1 Contract type: Coordination (or networking) actions

Result in Brief

• Good practice database to support women in research

Report Summary

• Final Report Summary - PRAGES (Practising gender equality in science)

relevant stakeholders.

It will be characterized by four particular elements: the attempt to integrate the most important and relevant results deriving from the studies and good practices relating to the fight against vertical segregation in various professional, political and social areas; enhancing the understanding of the exclusion of women as being deeply linked to what may be called the lack of socialisation of gender in science, that is, the resistance of scientific community to recognise and manage social and gender dynamics that drive the production of scientific research and its assessment.

Participants • THE UNIVERSITY OF MANCHESTER - United Kingdom • ASSEMBLEA DELLE DONNE PER LO SVILUPPO E LA LOTTA ALL’ESCLUSIONE SOCIALE – ASDO - Italia • THE UNIVERSITY OF QUEENSLAND - Australia • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE - United Kingdom • EUROPEAN UNIVERSITY INSTITUTE - Italia • AARHUS UNIVERSITET - Danmark • SIMMONS FEMALE COLLEGE - United States • UNIVERSITÀ DEGLI STUDI DI MILANO - Italia • TUDOMANYOS ES TECHNOLOGIAI ALAPITVANY - Magyarorszag

Coordinator

DIPARTIMENTO PER I DIRITTI E LE PARI OPPORTUNITÀ, PRESIDENZA DEL CONSIGLIO DEI MINISTRI - Italia

• UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • THE AUSTRALIAN NATIONAL UNIVERSITY - Australia

53

RASTANEWS

From 2013-02-01 to 2016-01-31 • RASTANEWS: www.rastanews.eu

Macro-Risk Assessment and Stabilization Policies with New Early Warning Signals

Objective RASTANEWS intends to enhance knowledge base, at both theoretical and an applied level, on many aspects of the future of macro-economic and monetary integration in Europe thus paving the way to a revised governance of the EMU, and the EU as a whole, in the wake of the debt crisis.

We see three key issues about the working of the EU macro-economy that deserve deeper investigation. The first is the issue of incomplete and informationally inefficient financial markets, the Achilles heel of the consensus DSGE models. The second, related issue, is the heterogeneity in expectations, which should play a fundamental role in explaining

Project details

Project reference: 320278 Status: Execution Total cost: EUR 3 072 059 EU contribution: EUR 2 439 775 Programme acronym: FP7-SECURITY Contract type: Small or medium-scale focused research project

the behaviour of asset prices. The third issue is the need to overcome the traditional dichotomy between Keynesian (short run) and neoclassical (long run) policy prescriptions. Taking these issues seriously has important implications for the conduct of EU monetary and fiscal policies and for EU governance system. In addition, to facilitate the timely identification of macro risks, we propose a new system of early warning indicators, to be implemented within the EMU surveillance mechanism. This proposal is consistent with our theoretical framework and is based on an empirical macro-finance approach.

Participants • FONDATION NATIONALE DES SCIENCES POLITIQUES - France • UNIVERSITEIT VAN AMSTERDAM - Nederland • BRUNEL UNIVERSITY - United Kingdom • QUEEN MARY AND WESTFIELD COLLEGE, UNIVERSITY

Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

OF LONDON - United Kingdom • RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG - Deutschland • KATHOLIEKE UNIVERSITEIT LEUVEN - Belgique/België • UNIVERSITÀ POLITECNICA DELLE MARCHE - Italia • UNIVERSITÀ CATTOLICA DEL SACRO CUORE - Italia • POLSKI INSTYTUT SPRAW MIEDZYNARODOWYCH - Polska • ISTITUTO PER GLI STUDI DI POLITICA INTERNAZIONALE - Italia • PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS Magyarorszag

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

SAFEGUARD

From 2011-10-01 to 2014-09-30

Safety Evaluation of Adverse Reactions in Diabetes

Objective In 2010 a widely marketed drug for the treatment of type 2 diabetes (T2DM) (rosiglitazone) was taken from the market as it was associated with an increased risk of myocardial infarction, a T2DM complication it was actually supposed to prevent. This example shows several things.

First, the approval requirements do not guarantee a longer term positive benefit risk profile. Second, large scale post-marketing studies are desperately needed to monitor the benefit risk profile throughout the lifecycle of T2DM drugs, and to achieve the required scale collaboration across countries is mandatory. Many novel T2DM drugs have come to the market, all on the basis of the same surrogate endpoints. New safety issues are constantly arising, such as potential associations with pancreatitis, pancreas cancer, bladder cancer, acute renal failure, etc.

In the SAFEGUARD Consortium we have assembled an excellent multidisciplinary group of experts who collaboratively aim to quantify the cardiovascular, cerebro-vascular and pancreatic safety risk of the T2DM

drugs, in particular the more novel drugs by investigating 1. published clinical trials and observational studies; 2. spontaneously reported adverse event reports in national and international pharmacovigilance databases; 3. data from nine population-based health care databases in six countries capturing longitudinal drug exposure and event data on more than 1.7 million T2DM patients. Data elaboration will be distributed but standardized through common protocols, data models and scripts.

To put the epidemiological results into perspective, intensive monitoring mechanistic studies in human will be conducted to further understand how and why these T2DM drugs may affect the cardiovascular, digestive or renal system. The SAFEGUARD consortium will yield a harmonized epidemiological data platform on a large T2DM population, which could easily be used to address newly occurring safety issues in the future.

Project details

Result in Brief

Project reference: 282521 Status: Execution Total cost: EUR 3 881 341 EU contribution: EUR 2 997 196 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH.2011.4.2-2 Contract type: Small or medium-scale focused research project

• Type 2 diabetes mellitus - drug safety and monitoring

Report Summary

• Periodic Report Summary - SAFEGUARD (Safety Evaluation of Adverse Reactions in Diabetes)

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Nederland

Participants • • • • • • • • • • • • • • • •

UNIVERSITAET BREMEN - Deutschland UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia UNIVERZITA KARLOVA V PRAZE - Ceska Republika AGENCIA ESPANOLA DE MEDICAMENTOS Y PRODUCTOS SANITARIOS - España FONDAZIONE SCIENTIFICA SIMG-ONLUS - Italia RESEARCH TRIANGLE INSTITUTE - United States UNIVERSITY OF BATH - United Kingdom CONSORZIO MARIO NEGRI SUD - Italia DRUG SAFETY RESEARCH TRUST - United Kingdom STICHTING VU-VUMC - Nederland BIPS - INSTITUT FUR EPIDEMIOLOGIE UND PRAVENTIONSFORSCHUNG GMBH - Deutschland PHARMO INSTITUTE N.V. - Nederland THE BRIGHAM AND WOMEN’S HOSPITAL, INC. - United States SYNAPSE RESEARCH MANAGEMENT PARTNERS SL - España PHARMO COOPERATIE UA - Nederland VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG Nederland

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SAFELAND

From 2009-05-01 to 2012-04-30 • SAFELAND: www.safeland-fp7.eu

Living with landslide risk in Europe: Assessment, effects of global change, and risk management strategies

Objective SafeLand will develop generic quantitative risk assessment and management tools and strategies for landslides at local, regional, European and societal scales and establish the baseline for the risk associated with landslides in Europe, to improve our ability to forecast landslide hazard and detect hazard and risk zones.

The scientific work packages in SafeLand are organized in five Areas: Area 1 focuses on improving the knowledge on triggering mechanisms, processes and thresholds, including climate-related and anthropogenic triggers, and on run-out models in landslide hazard assessment; Area 2 does an harmonisation of quantitative risk assessment methodologies for different spatial scales, looking into uncertainties, vulnerability, landslide susceptibility, landslide frequency, and identifying hotspots in Europe with

Project details

Project reference: 226479 Status: Completed Total cost: EUR 8 774 804 EU contribution: EUR 6 610 000 Programme acronym: FP7-ENVIRONMENT Subprogramme area: ENV.2008.1.3.3.1 Contract type: Large-scale integrating project

Result in Brief

• Learning to live with landslides

Report Summary

• Periodic Report Summary - SAFELAND (Living with landslide risk in Europe: assessment, effects of global change, and risk management strategies) • Final Report Summary - SAFELAND

Publications (27)via OpenAIRE

• Brief communication “A prototype forecasting chain for rainfall induced shallow landslides” Mercogliano, P. - Segoni, S. - Rossi, G. - Sikorski, B. - Tofani, V. Schiano, P. - Catani, F. - Casagli, N. • A stabilized Runge-Kutta, Taylor smoothed particle hydrodynamics algorithm for large deformation problems in dynamics Thomas Blanc - Manuel Pastor • Rockfall vulnerability assessment for reinforced concrete buildings Mavrouli, O. - Corominas, J.

Coordinator

STIFTELSEN NORGES GEOTEKNISKE INSTITUTT - Norge

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higher landslide hazard and risk; Area 3 focuses on future climate change scenarios and changes in demography and infrastructure, resulting in the evolution of hazard and risk in Europe at selected hotspots; Area 4 addresses the technical and practical issues related to monitoring and early warning for landslides, and identifies the best technologies available both in the context of hazard assessment and in the context of design of early warning systems; Area 5 provides a toolbox of risk mitigation strategies and guidelines for choosing the most appropriate risk management strategy. Maintaining the database of case studies, dissemination of the project results, and project management and coordination are defined in work packages 6, 7 and 8.

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Participants • TRL LIMITED - United Kingdom • ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Schweiz/Suisse/Svizzera • KING’S COLLEGE LONDON - United Kingdom • CENTRO EURO-MEDITERRANEO PER I CAMBIAMENTI CLIMATICI SCARL - Italia • GEOLOSKI ZAVOD SLOVENIJE - Slovenija • C.S.G. CENTRO SERVIZI DI GEOINGEGNERIA - Italia • UNIVERSITÀ DEGLI STUDI DI FIRENZE - Italia • UNIVERSITÉ DE LAUSANNE - Schweiz/Suisse/Svizzera • UNIVERSITAT POLITECNICA DE CATALUNYA - España • UNIVERSITÀ DEGLI STUDI DI SALERNO - Italia • INTERNATIONALES INSTITUT FUER ANGEWANDTE SYSTEMANALYSE - Österreich • RISQUES ET DEVELOPPEMENT - France • EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH Schweiz/Suisse/Svizzera • BUREAU DE RECHERCHES GEOLOGIQUES ET MINIERES France • STUDIO GEOTECNICO ITALIANO SRL - Italia • AMRA - ANALISI E MONITORAGGIO DEL RISCHIO AMBIENTALE SCARL - Italia • COMMISSION OF THE EUROPEAN COMMUNITIES DIRECTORATE GENERAL JOINT RESEARCH CENTRE – JRC Belgique/België • UNIVERSITEIT TWENTE - Nederland • GEOLOGISCHE BUNDESANSTALT - Österreich

• CENTRALE RECHERCHE SA - France • FUNDACION AGUSTIN DE BETANCOURT - España • MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. - Deutschland • INSTITUTUL GEOLOGIC AL ROMANIEI - Romania • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) - France • UNIVERSITA’ DEGLI STUDI DI MILANO-BICOCCA - Italia • ARISTOTELIO PANEPISTIMIO THESSALONIKIS - Hellas

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SAFERUBBER

From 2010-06-01 to 2013-05-31 • SAFERUBBER: www.saferubber.eu

A Safer Alternative Replacement for Thiourea Based Accelerators in the Production Process of Chloroprene Rubber

Objective In December 2007, the European Commission imposed a total of 247 635 000 fines on the five largest manufacturers of chloroprene rubber for participating in a cartel. As a result of this price fixing and market abuse by large enterprises, the SME involvement in this sector has diminished and requires research investment to re-build its presence. Additionally there is increasing pressure to replace the vulcanisation accelerator, ethylene thiourea (ETU), due to its assessment as a Cat 2 rep carcinogen as per the EU classification, IARC and EPA. It is believed that under REACH it will be classified as a CMR substance (Carcinogenic/Mutagenic/toxic for

Project details

Project reference: 243756 Status: Completed Total cost: EUR 2 637 682 EU contribution: EUR 2 010 392 Programme acronym: FP7-SME Subprogramme area: SME-2 Contract type: Research for SME associations/groupings

Result in Brief

• A safer rubber manufacturing process

Report Summary

• Periodic Report Summary 2 - SAFERUBBER (A Safer Alternative Replacement for Thiourea Based Accelerators in the Production Process of Chloroprene Rubber) • Periodic Report Summary 1 - SAFERUBBER

Documents

• Periodic Report 2 - SAFERUBBER • Periodic Report 1 - SAFERUBBER

Coordinator

ASSOCIAZIONE NAZIONALE COSTRUTTORI DI MACCHINE E STAMPI PER MATERIE PLASTICHE E GOMMA - Italia

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Reproduction) which will lead to legislation prohibiting or banning its use.

The SafeRubber project aims to develop a safer alternative accelerator to replace the carcinogenic ethylene thiourea (ETU) based accelerators to be used in the manufacturing of rubbers such as polychloroprene (CR) and epichlorohydrin (ECO). This will be based around a new catalyst molecule that has tri-functionality, which offers the added benefit of reducing consumption of metal oxides during manufacturing, lowering manufacturing costs and giving SMEs another unique differentiator, allowing them to compete in the market.

Participants • EUROPEAN TYRE AND RUBBER MANUFACTURERS’ ASSOCIATION - Belgique/België • MGN TRANSFORMACIONES DEL CAUCHO SA - España • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • THE UK MATERIALS TECHNOLOGY RESEARCH INSTITUTE LIMITED - United Kingdom • ROBINSON BROTHERS LIMITED - United Kingdom • GRAND SYNTHESIS LATVIA - Latvija • ASSOCIATION DES PRODUCTEURS D’ARTICLES EN MATIERES PLASTIQUES ET ELASTOMERES ASBL - Belgique/België • CLWYD COMPOUNDERS LIMITED - United Kingdom • BRITISH RUBBER AND POLYURETHANE PRODUCTS ASSOCIATION LIMITED - United Kingdom • NORNER AS - Norge • MIXER SPA - Italia • NORNER INNOVATION AS - Norge

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

SAHWA

From 2014-01-01 to 2016-12-31

Empowering the young generation: towards a new social contract in South and East Mediterranean countries (SAHWA)

Objective Young people in the South and East Mediterranean area are enduring a multiple transitions. In addition to the political and socioeconomic transformations, there is the transition to adulthood from the famous tripartite division of the life cycle in preparation for professional life, working life and retirement. Other experiences of socio-economic transformation, as in East Europe, may give us learnt lessons to manage economic, political and social change. Today, there are no longer substantial differences separating the young people of west and east. Nevertheless, there are important differences in economic resources, education and social between two shores of the Mediterranean.

In addition, the SEM young Europeans differ in cultural values and practices different from their counterparts in the north. Still, some processes linked to

Project details

Project reference: 613174 Status: Accepted Total cost: EUR 3 117 791 EU contribution: EUR 2 498 526 Programme acronym: FP7-SSH Subprogramme area: SSH.2013.4.1-2 Contract type: Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries (SICA)

Coordinator

CENTRE FOR INTERNATIONAL INFORMATION AND DOCUMENTATION IN BARCELONA - España

economic globalization and the precarious living conditions, labor and difficulties in individual empowerment, among others, suggest the emergence of a youth crime and its consolidation as a category of scientific analysis. This argument lets you put so research that supports integrating the European experiences in youth employment, political participation and gender equality, the youth situation in the context of transition and European double in similar scenarios on the south bank. To articulate such research dimensions the project will articulate the concept of triple transition, taking into account political transitions, socio-economic transitions, and “invisible” transition such as cultural trends and emotions related to youth and the insecurity about the future (“resident generation”)...

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • NUORISOTUTKIMUSSEURA RY UNGDOMSFORSKNINGSSALLSKAPET RF - Suomi/Finland • THE UNIVERSITY OF LIVERPOOL - United Kingdom • CENTRE DE RECHERCHE EN ECONOMIE APPLIQUEE POUR LE DEVELOPPEMENT - Algeria • LEBANESE AMERICAN UNIVERSITY NON PROFIT CORPORATION - United States • MIDDLE EAST TECHNICAL UNIVERSITY - Turkey • FUNDACION EDUCACION PARA EL EMPLEO - España • UNIVERSIDAD DE LLEIDA - España • UNIVERSITAET BREMEN - Deutschland • UNIVERSITY OF PLOVDIV - Bulgaria • HEM - Morocco • ANIMA INVESTMENT NETWORK - France • CENTRE FEMME ARABE FORMATION RECHERCHE ASSOCIATION - Tunisia • THE AMERICAN UNIVERSITY IN CAIRO - Egypt

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SEATIDE

From 2012-12-01 to 2015-11-30 • SEATIDE: www.seatide.eu

Integration in Southeast Asia: Trajectories of Inclusion, Dynamics of Exclusion

Objective The project SEATIDE brings together Southeast Asian (SEA) and European researchers with two objectives: research and network development. Research. Using locally focused field study methodologies, our experience of research on integration frameworks in Southeast Asia shows that historical and contemporary integrative processes include some groups and exclude others. Exclusion of communities presents risks to human development and security, even of framework disintegration. This understanding directs our research question: in processes of integration, who is excluded? We address it in thematic work packages with relevant qualitative/quantitative case studies guided by a common analytical framework focused on four key issues: diversity, prosperity, knowledge and security. Attention to SEAs sub-regions

Project details

Project reference: 320221 Status: Execution Total cost: EUR 3 049 104 EU contribution: EUR 2 415 071 Programme acronym: FP7-SSH Subprogramme area: SSH.2012.4.1-2 Contract type: Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries (SICA)

Coordinator

ECOLE FRANCAISE D’EXTREME-ORIENT - France

and globalisation/transnational issues defines our approach. Structuring the European Research Area (ERA).

On the basis of existing structures the unique EFEO network of 10 field centres in SEA, plus ECAF, EUROSEAS, ASEF we work for the development of effective, integrated networks of EU-SEA research, embracing Western European and ASEAN-founder countries alongside Eastern/Southern Europe and post-communist SEA nations. Broad dissemination of results is essential to the projects success, through conferences, publications, press coverage and policy briefs. Our recent and innovative research serves to improve the dialogue initiated in the EFEOs FP7 project IDEAS between social scientists and policymakers.

Participants • UNIVERSITAET HAMBURG - Deutschland • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • CHIANG MAI UNIVERSITY - Thailand • UNIVERSITI SAINS MALAYSIA* - Malaysia • TALLINN UNIVERSITY - Eesti • GADJAH MADA UNIVERSITY - Indonesia • COLLEGE OF ST MARY MAGDALENE IN THE UNIVERSITY OF CAMBRIDGE ROYAL CHARTER - United Kingdom • VIEN KHOA HOC XA HOI VIET NAM - Viet Nam

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

SIERA

From 2011-10-01 to 2014-09-30

Integrating Sina Institute into the European Research Area

Objective The rapid growth of cross-border markets and global concerns are creating a huge demand to facilitate knowledge sharing between societies.

The diversity of languages, cultures, and standards are the main barriers to sharing and consuming knowledge. The objective of the SIERA project is to reinforce closer and sustainable scientific cooperation between Palestinian and EU scientists in the field of multilingual and multicultural knowledge sharing technologies.

This objective is attained through integrating BZU Sina Institute, which is the largest ICT research centre in Palestine and among a few in the Arab world in this field, into the European Research Area. BZU Sina institute will twin with four leading European research institutions that are pioneers in

Project details

Project reference: 295006 Status: Execution Total cost: EUR 609 535 EU contribution: EUR 550 515 Programme acronym: FP7-INCO Subprogramme area: INCO.2011-6.2 Contract type: Support actions

Report Summary

the area of multilingual knowledge sharing and have an excellent profile in research cooperation at the European and international levels. This collective expertise and scientific excellence will be utilized to help BZU Sina Institute enhance its research cooperation capacity.

In particular, the project aims at achieving the following specific goals: (i) Widening the R&D strategy of BZU Sina Institute, (ii) setting up joint research and cooperation, (iii) facilitating PhD students co-supervision, (iv) Organizing joint summer courses, (v) building competency and facilitating the participation of BZU Sina Institute in FP7, and (vi) increasing the visibility and impact of BZU Sina Institute at the regional and international levels.

Participants • BERLIN-BRANDENBURGISCHE AKADEMIE DER WISSENSCHAFTEN - Deutschland • UNIVERSIDADE NOVA DE LISBOA - Portugal • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • UNIVERSITÀ DEGLI STUDI DI TRENTO - Italia

• Periodic Report Summary - SIERA (Integrating Sina Institute into the European Research Area)

Documents

• Periodic Report - SIERA

Coordinator

BIRZEIT UNIVERSITY - West Bank And Gaza Strip

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SINERGY

From 2013-11-01 to 2016-10-31 • SINERGY: sinergy-project.eu

SILICON FRIENDLY MATERIALS AND DEVICE SOLUTIONS FOR MICROENERGY APPLICATIONS

Objective This proposal selects a series of relevant examples of power microgeneration and storage (thermoelectric generators, vibrational harvesters and microstructrured batteries) and pushes them further into their development and performance maturity. With that goal in mind the emphasis is put on the materials themselves and their integration route into a technology able to bring the eventual solutions closer to an exploitable phase. For this reason we consider novel silicon technology compatible materials as our starting point. The combination of those materials with device-making silicon micro and nanotechnologies is especially well positioned to make breakthrough developments in the microdomain regarding energy harvesting and storage.

This approach enables (a) nanostructuration of the materials themselves, (b) dense device architectures by means of 3D high aspect ratio microstructures -which increase the resulting energy density, and (c) open the path for min-

Project details

Project reference: 604169 Status: Execution Total cost: EUR 4 824 461 EU contribution: EUR 3 794 913 Programme acronym: FP7-NMP Subprogramme area: NMP.2013.2.2-4 Contract type: Small or medium-scale focused research project

iaturized complete systems through the compact assembly of the different elements involved (e.g. harvesters, batteries, power control electronics, devices to be powered) by means of hybrid or monolithic integration strategies.

Wafer level processes will be favoured to assure an easier transferability of the results to a fabrication stage. The high density architectures and system manufacturability provided by silicon micro and nanotechnologies endorse the use of silicon friendly materials even when their intrinsic properties may lag behind other technologically exotic material alternatives. Two application scenarios, engine/machinery fault prevention and tire pressure monitoring systems, relying on self-powered wireless sensor networks, have been chosen as frame of reference for our microenergy developments since they offer different harvesting opportunities (vibrations and waste heat) and realistic and long term scenarios to work on.

Participants • INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW Belgique/België • CONSIGLIO NAZIONALE DELLE RICERCHE - Italia • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • ELECTROLUX ITALIA S.P.A. - Italia

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS - España

• STICHTING IMEC NEDERLAND - Nederland • FUNDACIO INSTITUT DE RECERCA DE L’ENERGIA DE CATALUNYA - España • STE SAS DI GUIDO MOIRAGHI E C. - Italia • CONFINDUSTRIA EMILIA ROMAGNA RICERCA SCARL - Italia

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

SOCIAL POLIS

From 2007-12-01 to 2010-11-30 • SOCIAL POLIS: www.socialpolis.eu

Social platform on cities and social cohesion

Objective This proposal outlines the organisation and strategic activities of a social platform, Social Polis, for the development of a research agenda and scientific dialogue addressing the role of cities and social cohesion. Its central purpose is to engage significant stakeholders from the scientific, civil society and governance sectors in establishing key scientific and policy issues for the agenda, informing focussed and coherent FP7-SSH calls for proposals on this theme in March 2008 and June 2009. Social Polis will mobilise a wide range of relevant findings, recommendations and scientific/practitioner networks from previous research projects under Framework Programmes 4, 5 and 6. Building on these experiences, Social Polis will organise consultation with a wide network of researchers and other stakeholders, including two workshops and one large-scale conference.

Project details

Project reference: 217157 Status: Completed Total cost: EUR 1 629 120 EU contribution: EUR 1 461 263 Programme acronym: FP7-SSH Subprogramme area: SSH-2007-2.2-01 Contract type: Coordination (or networking) actions

Coordination and support activities will include: surveying relevant literature, starting from the conclusions of FP4, 5 and 6 projects, for findings, recommendations, missing topics and methodological shortcomings, to define a future research agenda on Cities and Social Cohesion in Europe and the world; meetings and other forms of consultation with different groups of significant stakeholders; synthesising research agendas and set priorities; preparing two draft call texts on Cities and Social Cohesion (for FP7-SSH-2008 and -2009) organising a semi-permanent meeting room between significant stakeholders, which will ultimately lead to the establishment of a Social Platform; following developments in international research, stakeholder and policy debates relating to cities and social cohesion; dissemination and provision of educational resources.

Participants • UNIVERSITEIT VAN AMSTERDAM - Nederland • UNIVERSITAT DE BARCELONA - España • KATHOLIEKE UNIVERSITEIT LEUVEN - Belgique/België • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • THE UNIVERSITY OF MANCHESTER - United Kingdom

Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE - United Kingdom

• UNIVERSITE DE QUEBEC A MONTREAL - Canada • CENTRE DE RECHERCHE ET D’INFORMATION SUR LA DEMOCRATIE ET L’AUTONOMIE - France • ITER SRL - CENTRE RICERCHE E SERVIZI - Italia • WIRTSCHAFTSUNIVERSITAT WIEN - Österreich • FUNDACAO DA UNIVERSIDADE DE LISBOA - Portugal

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SOLAR DESIGN

From 2013-01-01 to 2015-12-31 • SOLAR DESIGN: www.solar-design.eu

On-the-fly alterable thin-film solar modules for design driven applications

Objective The demand for aesthetically integrated photovoltaic materials is increasing steadily in many industries. A growing number of designers, architects and industrial manufacturers across the world share a common interest in using Photovoltaics (PV) as a decentralized and sustainable source of energy in their product designs. Developing markets such as sustainable housing, temporary building structures, outdoor activities, electro-mobility and mobile computing will drive the demand for decentralized, attractive energy solutions.

For solar powered products are customisable shapes, sizes, colours, transparencies or specific electrical properties required, which have a decisive influence on the acceptance on the market. Therefore a new breed of solar technologies is necessary.

To achieve this goal new flexible production processes and materials

Project details

Project reference: 310220 Status: Execution Total cost: EUR 3 712 054 EU contribution: EUR 2 716 423 Programme acronym: FP7-NMP Subprogramme area: NMP.2012.4.0-1 Contract type: Collaborative Project targeted to a special group (such as SMEs)

Coordinator

TECHNISCHE UNIVERSITAET WIEN - Österreich

need to be developed.

A novel manufacturing process will enable the adjustment of all properties of a Cu(In, Ga)Se2 (CIGS) thin-film module on-the-fly and facilitate the production of customized photovoltaic modules with the desired voltage, size and shape. Combined with the material characteristics given by the underlying CIGS thin-film solar cell technology a new-breed of design-led, sustainable and decentralised energy solutions can be realized.

Furthermore the designer or architect who wants to incorporate solar electricity into his work needs a service environment to be assisted in the creative process. Tools should support the designer in conceiving, planning and producing the solar design products. This project will address the above mentioned challenges by exploring and developing new materials, manufacturing and business processes in PV powered product design and architecture.

Participants • • • • • •

• • • •

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UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia EUSKAL HERRIKO ELEKTRONIKA ETA INFORMAZIO - España FACHHOCHSCHULE MUNCHEN - Deutschland STUDIO ITINERANTE ARQUITECTURA SL - España RHP-TECHNOLOGY GMBH & CO KG - Österreich ACCADEMIA EUROPEA PER LA RICERCA APPLICATA ED IL PERFEZIONAMENTO PROFESSIONALE BOLZANO (ACCADEMIA EUROPEA BOLZANO) - Italia COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES - France INNOVATEC SENSORIZACION Y COMUNICACION, S.L. - España SUNPLUGGED - SOLARE ENERGIESYSTEME GMBH - Österreich FAKTOR 3 APS - Danmark

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

SOS

From 2008-11-01 to 2012-04-30

Safety of non-steroidal anti-inflammatory drugs

Objective The Safety Of non-Steroidal anti-inflammatory drugs (SOS) proposal aims to assess the relative cardiovascular (CVD) and gastrointestinal (GI) safety of non-steroidal anti-inflammatory drugs (NSAIDs). The NSAIDs are divided in traditional NSAIDs (tNSAIDs) and the newer COX-II inhibitors(coxibs).

The aim will be fulfilled by a two-phase approach comprising systematic reviews and synthesis of CVD and GI risk information from clinical trials and published observational studies, followed by the design and conduct of a multi-country study in existing health care databases in the UK, Netherlands, Germany and France, comprising medical information on at least 35 million persons. A data ware house will be constructed that will contain all pre-specified and locally elaborated anonimized data from inception cohorts of NSAID users. Data elaboration is standardized through a common protocol that will be designed on the basis of information and knowledge gaps observed in the systematic literature reviews, plus information

Project details

Project reference: 223495 Status: Completed Total cost: EUR 3 767 705 EU contribution: EUR 2 800 000 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH-2007-4.2-2 Contract type: Small or medium-scale focused research project

Result in Brief

• Revisiting the safety of non-steroid anti-inflammatory drugs

Report Summary

• Periodic Report Summary 1 - SOS (Safety of non-steroidal anti-inflammatory drugs) • Periodic Report Summary 2 - SOS • Final Report Summary - SOS

requirements for the statistical and decision models. The database study will yield risk estimates for CVD and GI bleeding for each individual NSAID by dose and duration and by other important effect modifiers (e.g. aspirin use). Separate models will be built for children since the indications and dosages differ and little is known on the safety of NSAIDs in this group as they are often prescribed off-label. Special emphasis will be put on the assessment and evaluation of methodological issues, such as confounding by indication, and outcome validity as these constitute the most important threats to the interpretation, robustness and perceived validity of observational studies. The results of the literature reviews, analysis of observational databases and re-analysis of published studies will feed into a decision model for clinicians to support treatment decisions and a decision model for regulatory authorities that will focus on the public health risk.

Participants • • • • • • •

UNIVERSITAET BREMEN - Deutschland UNIVERSITE VICTOR SEGALEN BORDEAUX II - France THE UNIVERSITY OF NOTTINGHAM - United Kingdom UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia AZIENDA OSPEDALIERA DI PADOVA - Italia RESEARCH TRIANGLE INSTITUTE - United States FUNDACIO INSTITUT MAR D'INVESTIGACIONS MEDIQUES IMIM - España • AZIENDA SANITARIA LOCALE DELLA PROVINCIA DI CREMONA Italia • PHARMO COOPERATIE UA - Nederland • THE RESEARCH INSTITUTE OF THE MC GILL UNIVERSITY HEALTH CENTRE - Canada

Documents

• Periodic Report 2 - SOS • Final Report - SOS

Publications via OpenAIRE

• Stroke risk and NSAIDs: a systematic review of observational studies Cristina Varas-Lorenzo - Nuria Riera-Guardia - Brian Calingaert - Jordi Castellsague - Antoine Pariente - Lorenza Scotti - Miriam Sturkenboom - Susana Perez-Gutthann

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Nederland

65

SWAB

From 2013-05-01 to 2018-04-30

Shadows of Slavery in West Africa and Beyond. A Historical Anthropology

Objective Though the colonial abolition of West African slavery and slave trade is well researched, the aftermath of slavery still deserves attention. What does it mean to be of slave descent today? How does the legacy of slavery and the slave trade overlap with harsh contemporary forms of marginality and exploitation? Moreover, what do we see when these questions are raised in a much broader comparative perspective? This project looks at the follow up of the abolition of slavery and the slave trade, a global process that invested the world at different times with a rich and complex variety of outcomes.

Most historical research has stopped at the early colonial period, a very well documented phase of world history. Here, the analysis expands up to the present, and beyond the boundaries West African studies. Four regions of the world, which are under scrutiny for trafficking and contemporary

Project details

Project reference: 313737 Status: Execution Total cost: EUR 935 100 EU contribution: EUR 935 100 Programme acronym: FP7-IDEAS-ERC Subprogramme area: ERC-SG-SH6 Contract type: ERC Starting Grant

Principal Investigator Prof. Alice Bellagamba

Host Institution

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

Beneficiaries

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

66

slavery, will be studied comparatively. These are Eastern Senegal (West-Africa), Libya (North Africa), Coastal Madagascar (Indian Ocean), and North Afghanistan (Central Asia). The ambition is to link the micro-study of lived experience, cultural meanings and practices with the analysis of linkages and broader historical processes. To get results, there is need of a dialogue with human rights, legal theory, studies of gender and racial discrimination as well as scholarly insights on globalization and neo-liberalism.

The ultimate objective of the project is an analytically integrated study of the aftermath of slavery that captures both the variety of concrete case-studies and the larger history of linkages between different parts of Africa and the world, Europe included. Innovation stands at the crossroad of chronological, geographical and disciplinary boundaries.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

SYNAPSE

From 2012-12-01 to 2015-11-30 • SYNAPSE: synapse.mdm.imm.cnr.it

SYnthesis and functionality of chalcogenide NAnostructures for PhaSE change memories

Objective The SYNAPSE project aims at the metalorganic chemical vapor phase deposition (MOCVD) and study of chalcogenide single material, (core) and double material (core-shell) nanowires (NWs), for innovative multi-level phase change memories (PCM). Although Ge-Sb-Te is the most studied material for PCM applications, In-based materials, like In-Sb-Te or In-GeTe alloys, are also promising, because they are featured by low reset current and high crystallization temperature, paving the way for performing data storage devices even in the automotive field. At the same time, a great attention is currently devoted to the chance to downscale PCM cells by employing chalcogenide NWs. In SYNAPSE, Ge-based and In-based NWs will be first deposited by MOCVD on different substrates and using different bottom-up approaches, the vapor-liquid-solid (VLS) and the selective area growth (SAG) methods. Single material nanowire (SM-NWs) will be in-situ MOCVD-coated by other phase change chalcogenides, to obtain core-shell

Project details

Project reference: 310339 Status: Execution Total cost: EUR 3 231 717 EU contribution: EUR 2 206 640 Programme acronym: FP7-NMP Subprogramme area: NMP.2012.2.2-2 Contract type: Small or medium-scale focused research project

nanowires (CS-NWs), both free-standing and buried in a template matrix.

Different material combinations (Ge-Sb-Te/In-Sb-Te/In-GeTe) will be explored in the realization of the CS-NWs aiming at developing multilevel PCM devices. The NW synthesis will be supported by the development and test of precursors for MOCVD. A detailed study of the NW phase switching behaviour (reversible amorphous-crystalline transitions) will be carried out and correlated with materials properties. Special attention will be devoted to the investigation of electrical and thermal properties of the NWs, their phase formation/crystallization dynamics, size-dependent effects and structural/chemical composition. Experimental work will be supported by theoretical modelling and simulation of both crystallization dynamics and electro-thermal behaviour. The SYNAPSE consortium is formed by 7 participants (5 academic/research centers and 2 industries) from Italy (3), France (2), Germany (1) and Ireland (1).

Participants • UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK - Éire/Ireland • FORSCHUNGSZENTRUM JUELICH GMBH - Deutschland • MICRON SEMICONDUCTOR ITALIA SRL - Italia • AIR LIQUIDE ELECTRONICS SYSTEMS SA - France

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE - Italia

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

67

SYSINBIO

From 2008-12-01 to 2011-11-30 • SYSINBIO: www.sysbio.de

Systems Biology as a Driver for Industrial Biotechnology

Objective Metabolic engineering is an applied science focusing on developing new cell factories or improving existing ones. Metabolic engineering is an enabling science, and distinguishes itself from applied genetic engineering by the use of advanced analytical tools for identification of appropriate targets for genetic modifications and the use of mathematical models to perform in silico design of optimized cell factories. In recent years, there has been increasing focus on using mathematical models for design. SYSIBIO will coordinate European activities in the field of model driven metabolic engineering and also coordination of activities on other technologies required for state of the art metabolic engineering, e.g. metabolomics and

fluxomics.

The coordination of activities will involve establishing a database containing metabolic models for different industrially important microorganisms.

The database will also contain different simulation tools required for use of these models to identify metabolic engineering targets and use of these models for analysis of omics data. SYSINBIO will also coordinate the further development of techniques required for metabolic engineering, such as metabolomics, fluxomics and identification of mutations in evolved strains.

Furthermore, an important part of SYSINBIO will be coordination of education and training in the field of metabolic engineering in Europe.

Project details

Project reference: 212766 Status: Completed Total cost: EUR 1 485 204 EU contribution: EUR 996 545 Programme acronym: FP7-KBBE Subprogramme area: KBBE-2007-3-2-05 Contract type: Coordination (or networking) actions

Coordinator

CHALMERS TEKNISKA HOEGSKOLA AB - Sverige

Participants • VALTION TEKNILLINEN TUTKIMUSKESKUS - Suomi/Finland • UNIVERSITAET SIEGEN - Deutschland • EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH Schweiz/Suisse/Svizzera • DANMARKS TEKNISKE UNIVERSITET - Danmark • LUNDS UNIVERSITET - Sverige • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Schweiz/Suisse/Svizzera • TECHNISCHE UNIVERSITEIT DELFT - Nederland • NOVOZYMES A/S - Danmark • UNIVERSITAET DES SAARLANDES - Deutschland • STIFTELSEN FRAUNHOFER-CHALMERS CENTRUM FOR INDUSTRIMATEMATIK - Sverige • EVONIK DEGUSSA GMBH - Deutschland • UNIVERSIDADE DO MINHO - Portugal • CHR. HANSEN A/S - Danmark • DSM FOOD SPECIALTIES BV - Nederland • BASF SE - Deutschland • UNIVERSITAET STUTTGART - Deutschland • FLUXOME SCIENCES A/S - Danmark

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• BOGAZICI UNIVERSITY - Turkey • METABOLIC EXPLORER SA - France

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

THINFACE

From 2013-09-01 to 2017-08-31

Thin-film Hybrid Interfaces: a training initiative for the design of next-generation energy devices

Objective Organic thin-films constitute a fast growing area of electronic and opto-electronic devices that offer cost-effective and flexible solutions for e.g. improved energy efficiency and energy harvesting. Due to the achievements made during the past decade, the development of such sustainable energy devices has already reached an early commercialization stage, however, in order to further boost their uptake on the market, improvement of device efficiency and lifetime is still needed. Such improvement requires a profound knowledge about fundamental properties of thin-film hybrid interfaces and their implementation in devices – a knowledge that is already requested from established and new companies focusing on organic electronic and opto-electronic devices. With this project, we establish a network that trains and educates young researchers within the area of hybrid thin-film interfaces for sustainable energy devices. In order to provide training and education that are of both high quality and of relevance for the

Project details

Project reference: 607232 Status: Accepted Total cost: EUR 3 873 667 EU contribution: EUR 3 873 667 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2013-ITN Contract type: Networks for Initial Training (ITN)

market, the research training programmes are in this consortium based on a combination of state-of-the-art research and industrial development and production processes.

The consortium consists of 5 full university partners, 1 research organization, 2 full industry partners, 4 associate industry partners and 1 associate research organization. The partners in the consortium are deliberately chosen in order to build up a unique cluster between universities and companies. Such cluster provides the young researchers in the consortium strong competence on 1) state-of-the-art research, 2) innovation and entrepreneurship and 3) large through-put industrial production processes.

The training network combines expertise on modeling, thin-film formation, device fabrication and characterization (multidisciplinary aspect) in order to provide solutions for a range of different sustainable energy applications such as thin-film transistors and solar cells (intersectoral aspect).

Participants • UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 - France • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • TECHNISCHE UNIVERSITAET GRAZ - Österreich • SAES GETTERS S.P.A. - Italia • ASOCIACION - CENTRO DE INVESTIGACION COOPERATIVA

Coordinator

SYDDANSK UNIVERSITET - Danmark

EN NANOCIENCIAS - CIC NANOGUNE - España • DANFOSS POWER ELECTRONICS AS - Danmark • UNIVERSIDAD AUTONOMA DE MADRID - España

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TOLERAGE

From 2008-04-01 to 2012-09-30 • TOLERAGE: tolerage.eu

Normalisation of immune reactivity in old age from basic mechanisms to clinical application

Objective When restoration of the immune response in older age is the target of basic and clinical research, boosting innate and adaptive immunity, e.g. by more efficient vaccination strategies, is the general approach. However, TOLERAGE has a fundamentally different focus, i.e. restoring the age-dependent decline of auto-tolerance that underlies the development of the paradigmatic age-associated diseases atherosclerosis (AS) and rheumatoid arthritis (RA). These diseases represent the major medical and socioeconomic burden in aging societies. They start earlier in life but become clinically manifest with increasing age. To reach this aim a consortium of ten partner groups was formed that have an outstanding track record in areas of immunology pertinent for this task. The work of TOLERAGE will focus on three major issues, viz. 1. Investigating basic

principles of the induction of central and peripheral tolerance in mice against autoantigens, including heat shock protein 60 (HSP60) that has been shown to play a major role in the development of AS and RA. 2.

Determination of the mediators of central and peripheral tolerance that are responsible for the T effector/T regulatory cell dysbalance in older age in general and in AS and RA in particular. 3. Translation of the results obtained in (a) and (b) into practical application for the prevention and treatment of AS and RA by appropriate vaccines. For all partners, important technical platforms will be available, including unique transgenic and knockout mouse strains, sophisticated models for in vitro and in vivo transfection of dendritic cells (DCs) and a well established Functional Genomics Facility.

Project details

Publications (39)via OpenAIRE

Project reference: 202156 Status: Completed Total cost: EUR 10 136 875 EU contribution: EUR 7 736 931 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH-2007-2.2.2-1 Contract type: No contract type

Result in Brief

• Vaccinating against age-related autoimmunity

Report Summary

• Periodic Report Summary 1 - TOLERAGE (Normalisation of immune reactivity in old age - from basic mechanisms to clinical application) • Periodic Report Summary 2 - TOLERAGE • Final Report Summary - TOLERAGE

Documents

• Periodic Report - TOLERAGE • Final Report - TOLERAGE

Coordinator

MEDIZINISCHE UNIVERSITAET INNSBRUCK - Österreich

70

• PTX3 predicts severe disease in febrile patients at the emergency department Martijn D. de Kruif - Maarten Limper - Karlien Sierhuis - Jiri F. P. Wagenaar - C. Arnold Spek - Cecilia Garlanda - Alessia Cotena - Alberto Mantovani - Hugo ten Cate - Pieter H. Reitsma - Eric C. M. van Gorp • Mouse Hepatitis Virus Liver Pathology Is Dependent on ADP-Ribose-1 ‘’-Phosphatase, a Viral Function Conserved in the Alpha-Like Supergroup Klara Kristin Eriksson - Luisa Cervantes-Barragan - Burkhard Ludewig - Volker Thiel • Long Pentraxin 3/Tumor Necrosis Factor-Stimulated Gene-6 Interaction A Biological Rheostat for Fibroblast Growth Factor 2-Mediated Angiogenesis Daria Leali - Antonio Inforzato - Roberto Ronca - Roberta Bianchi Mirella Belleri - Daniela Coltrini - Emanuela Di Salle - Marina Sironi - Giuseppe Danilo Norata - Barbara Bottazzi - Cecilia Garlanda Anthony J. Day - Marco Presta

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Participants • DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Deutschland • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) - France • KAROLINSKA INSTITUTET - Sverige • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • UNIVERSITEIT UTRECHT - Nederland • FONDAZIONE HUMANITAS PER LA RICERCA - Italia • CENTER OF EXCELLENCE IN MEDICINE AND IT GMBH Österreich • KANTONSSPITAL ST. GALLEN - Schweiz/Suisse/Svizzera • FUNCTIONAL GENOMICS CONSORTIUM - Italia

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UNICELLSYS

From 2008-04-01 to 2013-03-31 • UNICELLSYS: www.unicellsys.eu

Eukaryotic unicellular organism biology systems biology of the control of cell growthand proliferation

Objective The overall objective of UNICELLSYS is a quantitative understanding of fundamental characteristics of eukaryotic unicellular organism biology: how cell growth and proliferation are trolled and coordinated by extracellular and intrinsic stimuli. Achieving an understanding of the principles with which bio-molecular systems function requires integrating quantitative experimentation with simulations of dynamic mathematical models.

UNICELLSYS bring together a sortium of leading European experimental and computational systems biologists that will study cell growth and proliferation at the levels of cell population, single cell, cellular network, large-scale dynamic systems and functional module. Building computational restructions and dynamic models will involve different precise quantitative measurements as well as complementary approaches of mathematical modelling. A major challenge will be the generation of comprehensive dynamic models of the entire trol system of cell growth

and proliferation, which will require integration of smaller sub-models and reduction of complexity. Implementation of the models will allow observing responses to altered growth ditions zooming in seamlessly from populations sisting of cells of different replicative age and cell cycle stage via genome-wide molecular networks, large dynamic systems to detailed functional modules. Employing computational simulations combined with experimentation will allow discovering new and emerging principles of bio-molecular organisation and analysing the trol mechanisms of cell growth and proliferation. The project will deliver new knowledge on fundamental eukaryotic biology as well as tools for quantitative experimentation and modelling. Detailed plans for dissemination and exploitation will ensure that UNICELLSYS will have major impact on the development of Systems Biology in Europe ensuring a competitive advantage of Europe in dynamic quantitative modelling of bio-molecular processes.

Project details

Publications (53)via OpenAIRE

Project reference: 201142 Status: Completed Total cost: EUR 15 436 639 EU contribution: EUR 11 700 000 Programme acronym: FP7-HEALTH Subprogramme area: HEALTH-2007-2.1.2-1 Contract type: Large-scale integrating project

Result in Brief

• Modelling eukaryotic cell growth and proliferation

Report Summary

• Periodic Report Summary 1 - UNICELLSYS (Eukaryotic unicellular organism biology, systems biology of the control of cell growth and proliferation) • Periodic Report Summary 2 - UNICELLSYS

Coordinator

GOETEBORGS UNIVERSITET - Sverige

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• Further developments towards a genome-scale metabolic model of yeast Paul D. Dobson - Kieran Smallbone - Daniel Jameson - Evangelos Simeonidis - Karin Lanthaler - Pinar Pir - Chuan Lu - Neil Swainston - Warwick B. Dunn - Paul Fisher - Duncan Hull - Marie Brown Olusegun Oshota - Natalie J. Stanford - Douglas B. Kell - Ross D. King - Stephen G. Oliver - Robert D. Stevens - Pedro Mendes • Mass spectrometry-based proteomics for systems biology Eduard Sabido - Nathalie Selevsek - Ruedi Aebersold • Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation Attila Csikasz-Nagy - Orsolya Kapuy - Attila Toth - Csaba Pal - Lars Juhl Jensen - Frank Uhlmann - John J. Tyson - Bela Novak

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Participants • MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. - Deutschland • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD - United Kingdom • HUMBOLDT-UNIVERSITAT ZU BERLIN - Deutschland • EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH Schweiz/Suisse/Svizzera • DANMARKS TEKNISKE UNIVERSITET - Danmark • CHALMERS TEKNISKA HOEGSKOLA AB - Sverige • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • THE UNIVERSITY OF EDINBURGH - United Kingdom • THE UNIVERSITY OF MANCHESTER - United Kingdom • STIFTELSEN FRAUNHOFER-CHALMERS CENTRUM FOR INDUSTRIMATEMATIK - Sverige • MEDIZINISCHE UNIVERSITAET WIEN - Österreich • FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA España • UNIVERSITAT POMPEU FABRA - España • ABERYSTWYTH UNIVERSITY - United Kingdom • VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG Nederland

• THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE - United Kingdom

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WORKABLE

From 2009-11-02 to 2012-11-01 • WORKABLE: www.workable-eu.org

Making capabilities work

Objective Making Capabilities Work (WorkAble) will scrutinise strategies to enhance the social sustainability and economic competitiveness of Europe by strengthening the capabilities of young people to actively shape their personal and work lives in knowledge societies and cope with today’s economic, cultural, demographic and technological challenges.

Bridging quantitative and qualitative methods, WorkAble will assess the potential of innovative European strategies for dealing with local labour-market demands and regional inequalities. Adopting a comparative and interdisciplinary approach, it will systematically analyse whether and how young people are enabled to participate in working life and society. Applying the Capabilities Approach as a common heuristic framework, 12 partners from different disciplines (educational science, sociology, economics, philosophy, political studies and social work) in 10 European countries will collaborate closely in a multidimensional research process.

WorkAble will survey whether and how the match between young people’s supply of skills and competencies and changing labour-market needs is sustained and secured, while simultaneously broadening their options for living in and actively shaping European knowledge societies.

It will explore how educational strategies are implemented and assess whether they enable young people to convert knowledge, skills and competencies into capabilities to function as fully participating active citizens. This calls for a three-phase research design: - a comparative institutional mapping and analysis of vocational and labour-market policies in all educational regimes - case studies to reconstruct the conceptions, aspirations and practices of local actors implementing educational and training programmes - quantitative secondary analyses of national and European longitudinal data revealing how effectively these strategies enhance economic performance and close the capability gap.

Project details

Documents

Project reference: 244909 Status: Completed Total cost: EUR 2 860 441 EU contribution: EUR 2 264 789 Programme acronym: FP7-SSH Subprogramme area: SSH-2009-1.1.1.

Contract type: Small or medium-scale focused research project

Result in Brief

• Periodic Report 1 - WORKABLE • Periodic Report 2 - WORKABLE • Final Report - WORKABLE

Publications via OpenAIRE

• Establishing Caseness, Institutional Selves and “realistic perspectives” - A German Case Study on the Transition from School to Work.

Düker, Jan - Ley, Thomas

• Helping youth find their way in work

Report Summary

• Periodic Report Summary 1 - WORKABLE (Making capabilities work) • Periodic Report Summary 2 - WORKABLE • Final Report Summary - WORKABLE

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Coordinator

UNIVERSITAET BIELEFELD - Deutschland

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

Participants • FORSCHUNGS- UND BERATUNGSSTELLE ARBEITSWELT Österreich • UNIWERSYTET WARSZAWSKI - Polska • HAUTE ECOLE SPECIALISEE DE SUISSE OCCIDENTALE Schweiz/Suisse/Svizzera • UNIVERSITÀ DEGLI STUDI DI PAVIA - Italia • EDINBURGH NAPIER UNIVERSITY - United Kingdom • CENTRE D’ETUDES ET DE RECHERCHES SUR LES QUALIFICATIONS - France • BBJ CONSULT AG - Deutschland • UNIWERSYTET IM. ADAMA MICKIEWICZA W POZNANIU - Polska • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • UMEA UNIVERSITET - Sverige • GOETEBORGS UNIVERSITET - Sverige • AARHUS UNIVERSITET - Danmark

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UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

XD-STRING

From 2012-09-01 to 2017-08-31

The Structure of the Extra Dimensions of String Theory

Objective How many dimensions does space have? According to everyday experience, three. Since antiquity, however, humans have wondered if there could also exist extra “hidden” dimensions. “String theory” was originally conceived to reconcile Einstein’s general relativity, which describes gravity, with quantum mechanics, which describes the subatomic world.

The theory postulates that all known elementary particles are actually tiny

Project details

Project reference: 307286 Status: Execution Total cost: EUR 679 200 EU contribution: EUR 679 200 Programme acronym: FP7-IDEAS-ERC Subprogramme area: ERC-SG-PE2 Contract type: ERC Starting Grant

vibrating strings. One of its predictions is that space has six extra dimensions, “wrapped” in a space too small to be accessible to our senses (and so far to experiments). The aim of the project is to determine the “shape” of this hidden space, to classify the possibilities admitted for it by string theory, and to determine its consequences on physics in the three ordinary dimensions; for example, on the properties of black holes.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

Principal Investigator Dr. Alessandro Tomasiello Tel: +39264482527 Fax: +39264486012

Host Institution

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

Beneficiaries

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

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YEASTCELL

From 2013-09-01 to 2017-08-31 • YEASTCELL: www.yeastcell.eu

Yeast Cell Factories: Training Researchers to Apply Modern Post-Genomic Methods In Yeast Biotechnology

Objective The YEASTCELL ITN will train 11 Early Stage Researchers for productive careers as research scientists and leaders in the public or private yeast biotechnology sectors. Yeast biotechnology spans fundamental and applied research and is an area with an immediate need for highly trained researchers to advance knowledge and to develop new applications. The training sortium comprises 9 Public Sector (6 Universities, 3 Research Institutes) and 4 Private Sector (2 large companies and 2 SME) partners. A research training programme embracing the philosophy of “use-inspired fundamental research” has been designed to provide all 11 ESRs with interdisciplinary research training in both the public and private sectors.

The research themes include yeast physiology and metabolism, metabolic engineering, mathematical modeling, genomics and bioinformatics, fermentation, synthetic biology and systems biology. In addition to training via collaborative research projects, ESRs will participate in courses at local

Project details

Project reference: 606795 Status: Execution Total cost: EUR 3 066 365 EU contribution: EUR 3 066 365 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2013-ITN Contract type: Networks for Initial Training (ITN)

Coordinator

UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK - Éire/Ireland

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and network levels to enhance their technical and academic skills. All ESRs will register for PhD degrees and will also take a separate postgraduate certificate course in commercialisation and entrepreneurship. Industry-led workshops, research sedments and site visits will provide specific training that prepares ESRs for research in the private sector. A comprehensive programme of advanced training in complementary topics and skills of relevance to both the public and private sectors is provided at the network level. As well as directly training 11 ESRs, the network training activities will provide opportunities for ~40 additional researchers and will promote long-term interactions between research groups at the partner Institutions.

The major impact of YEASTCELL will be a cohort of highly-trained ESRs with excellent career prospects in the yeast biotechnology sector and a lasting European training and research collaboration between public and private sector partners.

Participants • INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE France • TECHNISCHE UNIVERSITEIT DELFT - Nederland • CHALMERS TEKNISKA HOEGSKOLA AB - Sverige • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia • JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN - Deutschland • UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN - Éire/Ireland • EVOLVA BIOTECH A/S - Danmark • LALLEMAND SAS - France • LEIBNIZ - INSTITUT FUER PFLANZENGENETIK UND KULTURPFLANZENFORSCHUNG - Deutschland • TEKNOLOGIAN TUTKIMUSKESKUS VTT - Suomi/Finland

UNIMIB IN EUROPE PARTICIPATION OF THE UNIVERSITY OF MILANO-BICOCCA IN THE 2007-2013 FRAMEWORK PROGRAMME FOR RESEARCH AND TECHNOLOGICAL DEVELOPMENT

3D BIOMIMETICS

From 2014-03-01 to 2016-08-31

Scaffold Base Supramolecular Architectures as Protein Epitope mimetics for Biomedical Applications

Objective Synthetic molecules that mimic the structure of the part of a folded protein involved in recognition events (protein epitope mimetics, PEMs) can access biological targets previously deemed as “undruggable” and are considered as a potential source of future therapeutics. So far, PEMs could effectively mimic only individual secondary structure elements of peptides and proteins. The major goal of this project is the development of a novel versatile platform for the design of multifaceted 3D architectures as PEMs of higher order structure elements and discontinuous epitopes of bioactive protein surfaces. The platform is based on cyclic pseudopeptide scaffolds comprising triazole rings linked by conventional amide bonds that are designed to allow for precise topological positioning of biomolecules.

The synthetic strategy relies on sequential assembly on solid support of tailor-made building blocks through cycles of alternated amide coupling and Copper(I)-catalyzed azide-alkyne cycloaddition reactions. The building

Project details

Project reference: 627403 Status: Execution Total cost: EUR 218 349 EU contribution: EUR 218 349 Programme acronym: FP7-PEOPLE Subprogramme area: FP7-PEOPLE-2013-IOF Contract type: International Outgoing Fellowship (IOF)

blocks will be prepared in solution and using solid phase synthesis (SPS) to produce macromolecular units bearing bioactive peptide segments.

Conclusively, these PEM systems can provide further insight into protein folding mechanism and recognition processes of bioactive protein surfaces. On the other side, improving pharmacodynamic and pharmacokinetic properties of natural peptides and proteins, a number of biomedical applications can be targeted. Specific focus will be devoted to the development of PEM anti-infective agents and the mimicry of structural and functional properties of trimeric HR1 complex of the HIV-1 protein gp41. Moreover, the developed platform can allow for the design of chimeric PEM systems that present saccharide and peptide units in a convergent manner as in the surface of native glycoproteins. This “discontinuous epitope” approach will be applied to improve pharmacological properties of the antimicrobial PEM systems.

Participants • UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA - Italia

Subjects Chemistry

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UNIMIB IN EUROPE Participation of the University of Milano-Bicocca in the 2007-2013 framework programme for research and technological development