Journal of Dentistry and Oral Epidemiology (ISSN: 2770-0453) Open Access Research Article
Volume 2 – Issue 1
Investigation of Periodontal Disease Status in Acute Leukemia (Myeloid and Lymphoblastic) Greek Patients: A Case - Control Study Nikolaos Andreas Chrysanthakopoulos1,* and Eleftheria Vryzaki2 1
Dental Surgeon, Oncologist (MSc), Specialized in Clinical Oncology, Cytology and Histopathology, Dept. of Pathological Anatomy,
Medical School, University of Athens, Athens, Greece, Resident in Maxillofacial and Oral Surgery, 401 General Military, Hospital of Athens, Athens, Greece, PhD in Oncology (cand) 2
MD, PhD, Department of Dermatology, Rio University Hospital of Patras, Greece, Running head: Periodontal Indices and Risk of Acute
Hematopoietic Cancer, *
Corresponding author: Nikolaos Andreas Chrysanthakopoulos PhD, Dental Surgeon, Oncologist, Specialized in Clinical Oncology,
Cytology and Histopathology, Dept. of Pathological Anatomy, Medical School, University of Athens, Athens, Greece, Resident in Maxillofacial and Oral Surgery, 401 General Military, Hospital of Athens, Athens, Greece Received date: 10 May, 2022 |
Accepted date: 19 May, 2022 |
Published date: 23 May, 2022
Citation: Chrysanthakopoulos NA, Vryzaki E. (2022) Investigation of Periodontal Disease Status in Acute Leukemia (Myeloid and Lymphoblastic) Greek Patients: A Case - Control Study. J Dent Oral Epidemiol 2(1): doi https://doi.org/JDOE2200103 Copyright: © 2022 Chrysanthakopoulos NA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract Objectives: Oral manifestations in acute leukemia patients is a serious medical condition. The aim of the current research was to compare the periodontal condition in a group of acute, myeloid and lymphoblastic, leukemia (AM/ALL) patients with a control group of healthy individuals. Methods: 98 patients with AM/ALL and 196 controls were selected. The clinical measurements used to diagnose periodontal condition concerned probing depths (PPDs), clinical attachment loss (CAL), gingival index (GI), bleeding on probing (BOP), and oral hygiene habits. The models of chi-square test and logistic regression were used to assess the possible differences between AM/ALL patients and controls. Results: The mean ages were 65.7 ± 3.4 years and 66.2 ± 2.8 years for cases and controls, respectively. AM/ALL patients had worst periodontal parameters such as PPD (p = 0.052, OR =1.725, 95% CI = 0.995-2.00), tooth-brushing frequency (p = 0.046, OR = 0.581, 95% CI = 0.341-0.00), GI (p = 0.091, OR = 1.632, 95% CI = 0.924-2.88), and BOP (p = 0.011, OR = 2.05, 95% CI = 1.18-3.563), after adjustment for smoking, socio-economic and educational status, compared with healthy individuals. Conclusion: Individuals with AM/ALL presented deeper periodontal pockets than healthy controls, worse gingival inflammation, and bleeding on probing than healthy controls and poor oral hygiene practices such as daily tooth brushing. Keywords: Acute myeloid leukemia, acute lymphoblastic leukemia, adults, periodontal indices Abbreviations: AM/ALL: Acute, Myeloid and Lymphoblastic, Leukemia, PPD: Periodontal Condition Concerned Probing Depths, CAL: Clinical Attachment Loss, GI: Gingival Index, BOP: Bleeding on Probing, PD: Periodontal Disease,
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