ACG Capsule Brochure

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EVERYTHING YOU NEED TO FULFILL YOUR DIVERSE RANGE OF CAPSULE REQUIREMENTS

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ACG CAPSULES When it comes to capsule needs, ACG is the name to be reckoned with pride and recognition. With over 50 years of industry experience, ACG Capsules is one of the largest manufacturer of empty hard capsules. Our diverse range of capsules is designed to meet every capsule requirement. We offer capsules in a variety of sizes and colors. We also provide application-based capsules that are suitable for filling solids, liquids, semi-liquids and combination fills. We have also pioneered a unique technology solution for printing on hard capsules. This technology offers a distinct identity to brands, setting them apart from the competition.

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Our world-class capsule manufacturing facilities in India, Europe and Brazil (upcoming) cater to the pharmaceutical and nutraceutical industries in more than 100 countries. Our extensive global network of well-equipped warehousing facilities ensures quick deliveries to global markets. Our consistent approach to provide customized solutions anywhere in the world, have enabled us to work closely with our customers.

The ACG capsule manufacturing facilities* are • WHO GMP certified • ISO 9001:2000 and ISO 14001:2015 certified • EXCiPACT certified • Assigned with DMF registration number by the US FDA and Health Canada SciTech Centre - ACG’s R&D affiliate in Mumbai stands testimony to our continuous investment in innovative products and technologies. *Applicable certifications may vary from site to site

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ACG IN NUMBERS

5

100+

11

900+

15

20,000+

Decades of Industry Experience

Countries with Satisfied Customers

Global Track & Trace Line Implementations

Global Offices

Global Manufacturing Facilities

Machines Installed

100+

38,000+

Billion Capsules Production Capacity

Tons Packaging Films and Foils Produced Annually

OUR GLOBAL PRESENCE

UK

North America

Croatia UAE India

China Bangladesh Thailand Indonesia

Brazil Argentina

PRODUCTS WIDEST RANGE OF STANDARD CAPSULE SIZES IN ANY COLOR YOU NEED

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Capsule colors A colorful capsule not only increases the aesthetic appeal of the product but also provides an opportunity to manufacturers to create unique products for an impactful brand recall. With the development of more than 10,000 shades, ACG has proven expertise and sophisticated equipment set up for color development.

Apart from offering an incredible myriad color options to choose from, ACG also offers customized color solutions. Our experienced and knowledgeable team offers complete support to help you choose right colorants for the capsules to ensure product stability, compatibility and most importantly, regulatory compliance across the global market.

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Capsule sizes To meet the varied requirements of product dosage specifications of fill weight and volume, and patient convenience, ACG offers 15 different sizes in the capsules. These include the standard sizes between #00 to #5 plus special sizes like #000, and many extended length options.

000

00el

00

00sl

0xel

0el+

0el

0

1el

1

2el

2

3

4

5

Hard capsules fill weight chart Size

000

00el

00

0el

0

Volume (ml)

1.37

1.02

0.95

0.78 0.68

1el

1

2el

2

3

4

5

0.54

0.50

0.41

0.37

0.30

0.21

0.10

Powder weight in mg

Density (g/cc) 0.3

411

306

285

234

204

162

150

123

111

90

63

30

0.4

548

408

380

312

272

216

200

164

148

120

84

40

0.5

685

510

475

390

340

270

250

205

185

150

105

50

0.6

822

612

570

468

408

324

300

246

222

180

126

60

0.7

959

714

665

546

476

378

350

287

259

210

147

70

0.8

1096 816

760

624

544

432

400

328

296

240

168

80

0.9

1233

918

855

702

612

486

450

369

333

270

189

90

1.0

1370

1020 950

780

680

540

500

410

370

300

210

100

1.1

1507

1122

1045 858

748

594

550

451

407

330

231

110

1.2

1644 1224

1140

936

816

648

600

492

444

360

252

120

1.3

1781

1326

1235

1014

884

702

650

533

481

390

273

130

1.4

1918

1428

1330

1092

952

756

700

574

518

420

294

140

1.5

2055 1530

1425

1170

1020 810

750

615

555

450

315

150

Details for other sizes available on request

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Regular Gelatin Capsules ACGcaps™ GR For best performance, reliability & immediate release needs

Wide choice and flexibility •

Available in 15 sizes (000 to 5) and more than 10,000 color shades

Maximizes yield on high-speed filling machines •

Proven machine-friendly design

Regulatory compliant •

Meets high quality standards

Enhanced brand security and differentiation •

Supports customized intricate printing

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Regular HPMC Capsules ACGcaps™ HR Versatile capsules that meet dietary, functional & lifestyle preferences

Suitable for vegetarian products •

Made from natural plant-sourced cellulose. No animal origin materials used in manufacturing

Compatible with a wide range of formulations •

Superior heat stability with no cross-linking issues with the formulation

Suitable for moisture-sensitive formulations •

Low inherent moisture

Certified by relevant regulations •

Meets standards of Vegetarian society U.K., Certified Vegan, Non-GMO, Star ‘K’ Kosher and Halal

Maximizes yield on high-speed filling machines •

Proven machine-friendly design

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HPMC Plus Capsules ACGcaps™ H+ Clean, inert and robust capsules for pharmaceutical and nutraceutical products

Meets the requirement of challenging products •

Fulfills the dissolution performance requirement across all biological pH

Compatible with a wide range of formulations •

Superior heat stability with no cross-linking issues with the formulation

Suitable for moisture-sensitive formulations •

Low inherent moisture

Suitable for vegetarian products •

Made from natural plant-sourced cellulose. No animal origin materials used in manufacturing

Certified by relevant regulations •

Meets standards of Vegetarian society U.K., Certified Vegan, Non-GMO, Star ‘K’ Kosher and Halal

Maximizes yield on high-speed filling machines •

Proven machine-friendly design

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Delayed Release HPMC capsules ACGcaps™ HD Extends the release and protects acid sensitive ANIs

Prevents degradation of formulation by avoiding exposure to stomach acids •

Delays release of formulation by up to 60 minutes or until the capsule is in the intestine (i.e. pH > 5.5)

Easier and more convenient way to develop a modified-release product •

Eliminates the need for additional protective coating of formulation or capsule

Suitable for vegetarian products •

Made from natural plant-sourced cellulose. No animal origin materials used in manufacturing

Ideal choice for products like probiotics and enzymes •

Suitable for sensitive formulations

Certified by relevant regulations •

Meets standards of Vegetarian society U.K., Certified Vegan, Non-GMO, Star ‘K’ Kosher and Halal

Maximizes yield on high-speed filling machines •

Proven machine-friendly design

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Liquid Encapsulation Machine

Liquid Fill Capsules ACGcaps™ GL/HL Superior Liquid Encapsulation in Gelatin and HPMC

Suitable for a wide range of formulations •

Available in gelatin and HPMC variants

Ideal choice for filling liquids, semi-liquids, pastes, hot-melts and combination fills •

Specially designed for secured encapsulation of liquids

Enhanced brand identity enabling product line extension •

Distinct attractive appearance. Printing on capsules possible

Effective taste and odor masking of formulations •

Secure band sealing of capsules after encapsulation

Prevents the risk of de-coloration •

No plasticizer used in the capsule shell

End-to-end service •

By offering liquid encapsulation and band sealing machines

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Dry Powder Inhalation Capsules ACGcaps™ GI/HI Cornerstone of capsule based cDPI solutions

Suitable for a wide range of formulations •

Available in gelatin and HPMC variants

Enhanced drug effectiveness •

Designed for maximum dose delivery

Compatible with any commonly available inhalation device •

Efficient puncturing, cutting or “twist open” performance

Enhanced brand identity •

Wide choice of color and printing options

Maximizes yield on high-speed filling machines •

Proven machine-friendly design

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Gelatin Capsules for Clinical Trials ACGcaps™ GC Designed for double blind trials

Ideal for clinical trials to ensure integrity of double blind studies •

Specially designed to effectively mask drug and placebo with secured locking

Convenient and versatile to use •

Large internal space for accommodating uniquely shaped tablets

Wide choice and flexibility •

Available in AA, A & B sizes, and universally accepted standard colors

Improved patient compliance •

Easy to swallow

Maximizes yield on high-speed filling machines •

Proven machine-friendly design

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Fish Gelatin Capsules ACGcaps™ GF A proven alternate to bovine & porcine gelatin

Free from TSE risk associated with bovine or porcine gelatin sources •

Made from fish gelatin derived from non-ruminant material

Wide choice and flexibility for customers •

Available in many sizes and colors

Suitable for water and oxygen sensitive formulations •

Low water vapor transmission rate and low oxygen permeability

Certified by relevant regulations •

Kosher certified, compliant with EP and regulation N 999/2001 amendments

Maximizes yield on high-speed filling machines •

Proven machine-friendly design

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Combination Fill Capsules Many options, explore the possibilities

Suitable for a wide range of formulations •

Available in gelatin and HPMC variants

Suitable for fixed dose combination, multi-dose products or incompatible formulations •

Enables simultaneous filling of two or more formulations into a single capsule

Enables the best of both worlds in one dosage form •

Capable of combining solid and liquid formulations

Ideal for extending the product life cycle •

Easier way to accomplish brand differentiation

Maximizes yield on high-speed filling machines •

Proven machine-friendly design

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VALUE-ADDED SERVICES

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Customized Printing of Capsules ACGcaps™ Brandshield Wide range of options to enhance Brand Security & Differentiation

Enhances brand visibility •

Customized printing of graphic, logo or text on capsules

Provides effective protection against counterfeiting •

Intricate and secured printing technology

Eliminates the need for any capital investment •

One-stop solution from customized designing to supply of pre-printed capsules

Unique way to achieve effective brand differentiation •

“4C” solution enables attractive printing using up to 4 colors

Intricate way to prevent counterfeiting of capsules •

“360” solution enables full circular oriented printing using up to 2 colors

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Capsules with pearl like appearance ACGcaps™ Pearlz Elegant aesthetics that enhances brand appeal

Suitable for a wide range of formulations •

Possible in gelatin and HPMC variants

Wide choice and flexibility •

Available in many sizes and colors

Ideal for personal care and lifestyle products •

Renders a premium appearance to the product with a shiny lustre finish

Enhanced brand security and differentiation •

Supports customized intricate printing

Maximizes yield on high-speed filling machines •

Proven machine-friendly design

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Formulation Compatibility Support Supported by our strong R&D capabilities and expert resources, we work closely with the customers’ product development teams on aspects related to compatibility between the formulation and the capsule. This helps customers ensure selection of the right capsule at the development stage. We also work with customers on innovative customization of capsules to suit the formulation requirement and give them a competitive edge in the market.

Technical Services We believe that our responsibility does not end with the supply of right quality capsules. We go an extra mile in partnering with our customers to ensure that they achieve maximum productivity with our capsules on the filling machines. Leveraging our group level expertise in manufacturing of capsule-filling machines and engineering knowledge, our technical service team proactively helps customers in maximizing the yield. We also support them by overcoming the challenges associated with the capsule-filling process on the shop floor.

Regulatory Support With our rich global experience and exposure to all key markets, we are aligned with the regulatory requirements of both developed and emerging markets, laying emphasis on cross-country compliances.

We have a dedicated regulatory experts team that ensures process and product compliances for meeting the regulatory requirements of different markets. We work closely with our customers to actively support them on all documentary requirements for exporting products to the regulated markets of Europe and the USA.

Capsule Customization With our innovation capabilities and a wide range of manufacturing solutions, we help our customers in developing solutions customized for their needs. These include development of right colorants for regulatory compliance, special size of capsule, dosage optimization and unique multi-color and 360° circular printing on capsules to name a few.

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PRODUCT AND FACILITY CERTIFICATIONS*

HALAL CERTIFIED

*Applicability may vary for different capsule products and manufacturing facilities

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ARGENTINA ACG Argentina S.R.L. Centro Industrial Florida Oeste, Av. Gral. Julio A. Roca, No 4250/80 - Unidad 110, (B1604BZJ) Florida - Vicente López, Buenos Aires, Argentina Tel: +54 11 4709 2010 Email: sales.argentina@acg-world.com BANGLADESH ACG Bangladesh Pvt. Ltd. Plot No. 369, Road No. 28, Flat No. 4A New DOHS Mohakhali, Dhaka-1206, Bangladesh BRAZIL ACG Capsules S/A, 1714, Rua Vieira de Morais 1713, Cj 72 Campo Belo, São Paulo, 04617-015, Brazil Tel: +55 11 5096 1704 Email: sales.brasil@acg-world.com ACG Films & Foils Rua: Howard Achenson Junior n° 55 Jardim da Gloria, Cotia-SP 06711-280 Tel: +55 11 4613-7623 Email: sales.brasil@acg-world.com CHINA ACG (Shanghai) Co. Ltd. 1607, Guoli Mansion, 1465 Beijing Rd, Shanghai 200040 Tel: +86 21 5212 0007 Fax: +86 21 5212 0042 Email: sales.china@acg-world.com EUROPE ACG Europe Ltd. Corby Enterprise Centre, London Road, Corby NN17 5EU, United Kingdom Tel: +44 15 3656 0540 Email: sales.acpl@acg-world.com ACGIS Europe d.o.o.

Slavonska Avenida 19, 10 040 Zagreb, Croatia Tel: ++385 1409 5220 Email: sales.inspection@acg-world.com ACG Lukaps d.o.o. Frankopanska 79, 42230 Ludbreg, Croatia Tel: +385 1409 5220 INDONESIA P.T. ACG Indonesia JI. Gading Kirana Barat IX, Blok C10 No. 26, Kelapa Gading, Jakarta Utara - 14240, Indonesia Tel: +62 21 4587 4093 Fax: +62 21 4587 4011 Email: acg.indonesia@acg-world.com THAILAND ACG Capsules (Thailand) Co. Ltd. 75/22, Ocean Tower 2, 17th Floor, Soi Sukhumvit 19 (Wattana) Sukhumvit Road, Kwaeng Klongtoey Nua, Khet Wattana, Bangkok 10110, Thailand Tel: +66 2661 7771/2 Fax: +66 2661 1773 UAE ACG Fze SAIF Suit Y1-073, Sharjah Airport International, P.O. Box 121581, Sharjah, U.A.E Direct: 00971509099

ACG NORTH AMERICA, LLC 262 Old New Brunswick Road, Suite A, Piscataway, NJ 08854 Tel: +1 908 757 3425; Fax: +1 908 757 3287; Toll Free: +1 877 618 3344 Email: sales.acgna@acg-world.com

145, Kandivali Industrial Estate, Charkop, Kandivali (West), Mumbai - 400067, Maharashtra, India.

Tel: +91 22 3070 0118/19 Fax: +91 22 2868 6152 Email: sales.acpl@acg-world.com

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ACG CAPSULES (HEAD OFFICE)