1 PEG Effect and how to Apply PEG in the Repair Process Polyethylene glycol (PEG) is a synthetic polymer and a product of condensed ethylene oxide and water. Several types of PEGs are hydrophilic in nature, making the ideal penetration enhancers. Its repairing mechanism involves a lipid rearrangement process and making the water between molecules thermodynamically unfavorable, therefore inducing fusion (Lentz & Lee, 1999). As a fusogen, PEGs can be effectively used to repair injury sites at it enhances the regeneration process. It is effective for normal types of injuries and for nerve injury repair, promoting the re-innervation of nerve function. Despite not being used in clinical set ups, the use of PEGs in peripheral nerve repair is still a promising prospect in clinical practice. PEG provides a rapid and dramatic peripheral nerve repair option. In a study by Ghergherehchi et al. (2019), applying PEG at the ends of viable severed nerves showed positive effects including restoring axonal continuity, preventing Wallerian degeneration, preserving neuromuscular junctions, improving recovering of voluntary functions and preventing target muscle atrophy. Notably, PEG-fused allografts were not rejected even without tissue matching and immunosuppression technique.
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