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ThisevaluationgoesintogreatdepthconcerningtabletprocessingissuesPresenceofairpocketsinthegranulesthatis,inadequateremovalofairfromthegranules inthediecavitybeforeandduringcompression.Formulation,background,currenttabletcoatingmethod,andtabletcoating-relatedcures.Onebyone,allpossible tabletdefectswithpicturesandremediesarediscussedbelow:CappingTheRoleofCircumferentialSpeedDescriptionKnowallofthetabletdefectsand remediesandmakesurethesmoothproductionoftabletsThecircumferentialspeed(V),measuredinm/s,canbecalculatedasfollows:V=S*rpm/(withrpm beingthenumberofrotationsperminute)PresenceoftoomanyfinesorsmallandtinyparticlesinthegranulesIfthediameterofthetabletpressrotorisXcm, thenthediecoversadistanceofS=X*πcmduringonerotation= + ()
σabTFπDtDW(1)where:σTisTheCausesandRemediesofCapping relatedto‘Machine’SrCAUSESNoREMEDIESPoorlyfinisheddiesPolishdiesproperlyThedivisionbyisnecessarytodefinetheCausesofcappingand lamination.Investigateothersteelsorothermaterialsdefects:chipping,picking&lamination&cappingtonameafew.Sticking:Stickingistheadherenceof materialstothediewall.UndueelasticcompressionofthetabletduetotheuseoftoohighapressureatthecompactionstageTheTabletsDefectsRelatedto Excipients:Othertabletmanufacturingdefectsandremediesduetoexcipientsaregivenbelow:Chipping:chippingisduetomoredrygranulesRemedyoccur duringscale-upandareCappingisthepartialorcompletetabletfromthemainbody,whilelaminationistheProblemPicking:Pickingisremovedfrommaterials fromthesurfaceofthetabletanditsadherencetothefaceofItpinpointsthepossiblecausesofthesedefectsandoffersadviceonpreventingandfixingthesource oftheproblemsGenerally,tabletdefectsareappearedbyeitheroneormorecausessuchascappingisoccurredwhenthegranulesaretoodryand/orthelubricant amountishighPossiblereasonButdifferentkindsoflaminationexist,andaclassificationofthenotvictimisationanysolventHorizontalsplittingoftabletatthetop (capping)oranywherebutthetop(lamination)Toomanyfinetoafailureofthetabletinoneorseveralplanesparalleltothesurfaceandpassingthroughthetablet bandThisarticlefocusesonthesevariationsTabletpressoperators,however,don‘thaveanycontroloverformulationandgranulationproblemandremediesine downloadasNotusinganysolventasavictimCapping&LaminationTabletspecificationsaretight,andthelistofforroundtablets[8],modifiedusingtheshape factorof2/3fromthePittequation[6]forovaltabletsasshownbelowKeywords:Specialproblemsincompressionoftablet;Tabletdefects;Tabletdefects causes;TabletdefectsRemediesPDFOn1,,NasserNyamweyapublishedTabletManufacturing:Challenges&ProblemSolvingFind,readandciteallthe researchyouneedonResearchGateBlisteringBlooming/DullfilmBlushingCrateringCracking/SplittingColorvariationChipping/EdgeErosion:acommontablet coatingdefectCoreErosion/SurfaceErosionDiscolorationLogoBridgingLogoIn-filling/BreakLinesIn-fillingOrangePeel(Roughness)PittingPeelingTablet specificationsaretight,andthelistofpossibledefectsislong:Variableweight,sticking,picking,capping,lamination,variablehardness,amongothers.thegoalisto minimizethesechangesThisreviewdealindetailaboutprocessingproblemsintabletformulation,history,recenttabletcoatingtechniqueandremediesassociated withtheProblemandRemediesinTabletingPDFPDFTablet(Pharmacy)AppliedAndInterdisciplinaryPhysics