

A Message from the President and CEO
We are celebrating 25 years of 4Life Global and 15 years of 4Life Europe, a number that gives us more strength for the next challenges. Throughout these years, we have remained at the forefront of an ever-changing world, reinforcing who we are: the Immune System Company with values grounded in science, success, service, and satisfaction.
At 4Life Global Connexion, we had the opportunity to return to our roots, to our hometown of Salt Lake City, attending an event that allowed us to connect and rebuild from shared experiences. Why the theme of “Connexion”? Because we know nothing worthwhile can be built by one person alone.
The combined passion of many people sustains greatness. 4Life Founders David and Bianca Lisonbee knew this from the beginning, which is why they relied on others to help them build a solid foundation. 4Life wouldn’t be where it is today if it weren’t for the collaboration of our Affiliates and employees, and the support of our customers.
Let’s be together at the upcoming 4Life Europe Tour in January 2023, setting up goals to reach new milestones over the year. See you there!

Warm regards, Danny Lee
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Immune system support at the top of your mind? We get it. What products should you take? How frequently should you take them? What company should you trust with your well-being goals? These are all questions you have a right to ask.

With a growing list of patents, peer-reviewed studies, and award-winning products to its name, 4Life (The Immune System Company) makes it easy for anyone to benefit instantly from decades of immune system research and expertise. We have everything you’d expect from THE Immune System Company—products with essential nutrients to support your immune system and address your targeted needs for a healthy lifestyle. What’s more . . . we have something no other company can offer: 4Life Transfer Factor™!

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Not pictured:
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The 10 Commandments for a healthy Immune System

1. I get enough sleep
Research shows that adequate sleep is paramount for a high-functioning immune system. Sleep allows the immune system to do its work while the body is at rest. Lack of sleep can lead to more than just fatigue. It can also lead to a less effective immune system. 1,2

3. I practice good hygiene
Wash your hands frequently and avoid touching your face—especially after visiting a public place.

2. I consistently eat a nutritious diet
Consuming a high amount of fruits and vegetables is important, since these foods are generally rich in vitamins A, Folic Acid, Selenium and Zinc. These four nutrients contribute to a normal immune system function. 3,4,5,6

4. I exercise
Exercise is key for a healthy immune syste for many reasons. Not only does it keep you physically healthy, but it can also help reduce mental stress and even improve your quality of sleep. Moderate exercise is a great way to support a normal immune system. 7,8

6. I limit exposure to illness
It’s no secret that viruses are contagious. Avoid being in close contact with people who are ill or who have been exposed to an illness.
5. I dedicate time to total body recovery
Exercise is important, but resting after exercise is just as important. Give your body time to recoup after strenuous exercise with a day off and avoid overtraining, since it may wear you and your immune system out. 9


8. I minimize mental and physiological stress levels
Mental stress can have a biological effect on your immune system. Your physical reaction to stress can affect the normal functioning of your immune system. Manage stress to support your immune system. 11,12,13

7. I practice nourishing supplementation

Sometimes it’s not easy to nourish your body solely from the food you eat. A daily multivitamin or an immune system–support supplement can help you reach the daily requirements for vitamins specific to normal immune system function. 10

9. I avoid drugs and alcohol
Alcohol and drugs can limit the effectiveness of your immune system. There are correlations between drug and/or alcohol use and increased susceptibility to infections. 14
10. I get sufficient sun
Studies have shown that vitamin D is a key component for a highfunctioning immune system. Want a good source? Look no further than your backyard! Depending on the time of year, 5−30 minutes in the sun supports vitamin D synthesis. And during the months with fewer hours of sunshine you can supplement your diet with vitamin D..15

4Life is not endorsing these websites or vouching for the accuracy of any information found on these external sites.
Footnotes:
1.Besedovsky, L., Lange, T., & Born, J. (2012, January). Sleep and immune function. Pflugers Archiv: European journal of physiology. https://www.ncbi. nlm.nih.gov/pmc/articles/PMC3256323/
2. Besedovsky, L., Lange, T., & Born, J. (2012). The sleep-immune crosstalk in health and disease. Physiological reviews. https://pubmed.ncbi.nlm.nih. gov/30920354/
3.Carr, A. C., & Maggini, S. (2017). Vitamin C and immune function. Nutrients. https://pubmed.ncbi.nlm.nih.gov/29099763/
4.Gombart, A. F., Pierre, A., & Maggini, S. (2020). A review of micronutrients and the immune system-working in harmony to reduce the risk of infection. PubMed.gov. https://pubmed.ncbi.nlm.nih.gov/31963293/
5.Ueland, P. M., McCann, A., Midttun, Ø., & Ulvik, A. (2017). Inflammation, vitamin B6 and related pathways. Molecular aspects of medicine. https:// pubmed.ncbi.nlm.nih.gov/27593095/
6.Lee, G. Y., & Han, S. N. (2018). The role of vitamin E in immunity. PubMed. gov. https://pubmed.ncbi.nlm.nih.gov/30388871/
7.Gleeson, M. (2007). Immune Function in sport and exercise. PubMed.gov. https://pubmed.ncbi.nlm.nih.gov/17303714/
8.Wang, J., Liu, S., Li, G., & Xiao, J. (2020). Exercise regulates the immune system. PubMed.gov. https://pubmed.ncbi.nlm.nih.gov/32342473/
9.Peak, J. M., Neubauer, O., Walsh, N. P., & Simpson, R. J. (2017). Recovery of the immune system after exercise. Journal of Applied Psychology, 122(5), 1077-1087.
10.U.S. Department of Health and Human Services. (2018, February). Vitamins and minerals. National Center for Complementary and Integrative Health. https://www.nccih.nih.gov/health/vitamins-and-minerals
11.Dhabhar, F. S. (2014). Effects of stress on immune function: The good, the bad, and the beautiful. PubMed.gov. https://pubmed.ncbi.nlm.nih. gov/24798553/
12. Dragoş, D., & Tănăsescu, M. D. (2010). The effect of stress on the Defense Systems. PubMed.gov. https://pubmed.ncbi.nlm.nih.gov/20302192/
13.Ray, A., Gulati, K., & Rai, N. (2017). Stress, anxiety, and immunomodulation: A pharmacological analysis. PubMed.gov. https://pubmed.ncbi.nlm.nih. gov/28061967/
14. Friedman, H., Newton, C., & Klein, T. W. (2003). Microbial Infections, Immunomodulation, and Drugs of Abuse. Clinical Microbiology Reviews, 16(2), 209-219. doi:10.1128/cmr.16.2.209-219.2003
15. NIH. (2021, August 17). Office of dietary supplements - vitamin D. National Institutes of Health. https://ods.od.nih.gov/factsheets/vitamindhealthprofessional/
