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ItisThromboangiitisobliterans(TAO),aninflammatoryvasculopathyalsoknownasBuergerdisease,ischaracterizedbyaninflammatoryendarteritisthatcausesa prothromboticstateandsubsequentBuerger’sdiseaseorthromboangiitisobliterans:descriptionoftwocases•.StephaneLaurentThromboangiitisobliterans (TAO)isanonatherosclerotic,segmentalinflammatorydiseasethatmostcommonlyafectsthesmallandmedium-sizedarteriesandveinsinTreatmentfor Thromboangiitisobliteransistobaccocessation,whichpreventsthepatientundergoesafuturelimbamputationandpreventsthediseasefromspreadingtoother Thromboangiitisobliteransisinflammationandsubsequentblockageofsmallandmedium-sizedarteriesofthelegsorarmsThromboangiitisobliteranscommonly developsinThromboangiitisobliterans(TAO)wasfirstdescribedin,whenFelixvonWiniwarter,anAustriansurgeonwhowasanassociateofTheodorBillroth, reportedintheGermanThromboangiitisobliteransoralsocalledBuergerdisease,isaninflammatorydiseasethataffectsthearteries,especiallythoseofsmalland mediumcaliberandreachestheendsThromboangiitisobliteransisinflammatorythrombosisofsmallandmedium-sizedarteriesandsomesuperficialveins,causing arterialischemiaindistalextremitiesandsuperficialTheimportanceofsmokinginthediseaseonsetanditsmaintenance,itsepidemiology,itsdiagnosiscriteria, complementarystudies,proposedtreatmentsanditsnaturalevolutionOverviewofThromboangiitisObliterans(Buerger'sDisease)Aformofvasculitisassociated withahighlyinflam-matoryclotwithinthelumenaswellasinflammationwithinthevascularwallTendstoinvolvemedium-sizedarteriesandveins,withthemost strikingINTRODUCTIONThromboangiitisobliteransandendothelialfunction•Thromboangiitisobliterans(TAO),alsocalledBuergerdisease,isa nonatherosclerotic,segmental,inflammatorydiseasethatmostcommonlyaffectsthesmalltomedium-sizedarteriesandveinsoftheextremities(upperandlower)[ ]FigureTypicalAcuteHistologicLesionofBuerger'sDiseaseinaVeinwithIntenseThromboangiitis,ShowingaMicroabscessintheThrombusandTwo MultinucleatedGiantCells(Arrows)Thromboangiitisobliterans(TAO)isasegmentalocclusiveinflammatoryconditionofarteriesandveins,characterizedby thrombosisandrecanalizationoftheaffectedvessels[1,]DownloadFreePDFViewPDFEuropeanJournalofClinicalInvestigationGildaSANDRIItwas firstdescribedinbyDrLeoBuergerTAOismorecommoninmen,andisusuallydiagnosedbeforeyearsofageThromboangiitisobliteransorBuerger'sdiseaseis asegmentalocclusiveinflammatoryconditionofarteriesandveins,characterizedbythrombosisandrecanalizationoftheaffectedvesselsGoto:Epidemiology Buerger'sdiseaseorThromboangiitisObliterans(TAO)isasegmentalnon-atheroscleroticinflammatoryconditionthataffectsthesmallandmediumsizedarteries andveinsoftheextremitiesAssociatedwithactivecigarettesmoking,typicallymoderatetoheavyItisanon-atheroscleroticinflammatorydiseaseaffectingsmall andmediumsizedarteriesandveinsoftheupperandlowerextremities[]