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ASHappointedclinicalexperts,fivemethodologistsandpatientrepresentativestoreviewevidenceandformrecommendationsonSCDTherecommendations addresstreatmentofbothadultandpediatricSCDBackgroundSicklecelldiseasecontributessubstantiallytomortalityinchildrenyoungerthanyearsinsubSaharanAfricaWedidthecross-sectionalUgandaSickleSurveillanceStudytoassesstheburdenofdiseaseAmongbabiesagedmonthsoryounger,theoverall prevalenceofsicklecelltraitwas2%andofdiseasewas08%,whichsuggeststhatatleastbabiesperyeararebornwithsicklecelldiseaseinUgandaPrevalence rangedfrom25%to9%ResultSicklecelldiseaseinUganda:atimeforactionObjectiveBackground:Worldwide,theburdenofSickleCelldisease(SCD)has notbeenamplyaddressedInUganda,babiesperyeararethoughttobebornwithsicklecelldisease,butaccuratedataarenotavailableInUganda,|Find,read andcitealltheBulletinoftheWorldHealthOrganizationTLDRResults“Creatingawarenessandearlytestingofthesicklecelldiseasewhileensuringahealthy Result1dayago ByDanaD'AmicoByFrancesGatta.Thestudyusedanintervieweradministeredquestionnairestocollectthedata.Todeterminetheregional anddistrict-levelnewbornprevalenceofsicklecelltraitanddisease,andtheprevalenceof1, Sicklecelldiseaseisanumbrellaterminologythatdescribesa groupoflife-longdebilitatingautosomalrecessivedisorderswhichoccurasaresultofasingle-pointmutation(basechangefromIn,ASHinitiatedaneffortto developclinicalpracticeguidelinesonSickleCellDisease(SCD)Frompersonalizedmedicinetolabautomationtogenetherapy,bothestablishedandemerging areasResult, AbstractWHOhasindicatedtheneedtoimprovediseaseprevention,awarenessandearlydetectioninAfrica[7,]Prevalenceofsicklecelltrait indistrictsinUgandaThenationalprevalenceofhaemoglobinvariants,specificallythoseotherthansicklehaemoglobin,was0·5%,butrangedfrom0·1%inthe SouthWesternregionto18%intheWestNileregion(table2)PDFBackground:Sicklecelldiseasecontributessubstantiallytomortalityinchildrenyounger thanyearsinsub-SaharanAfrica.InUgandaestimatessuggestthat,babiesareborneachyearwithsicklecelldisease[].Thisisbelievedtobethehighestinthe wholeworldMethod:Thiscrosssectionalstudythereforesetouttodeterminetheattitudes,perceptionandlevelofawarenesstowardsSickleCelldiseasein Ugandancommunities/eamjv80iThepublishedliteraturefromAfricaandfromtheUSandCaribbeaninpopulationsofURNTheMinistryofHealthUgandahas launchedthefirst-evertreatmentguidelinesforsicklecelldiseasetoResultAbstractInAfrica,Ugandahasthe5thhighestburden,asituationResultVision StatementTheprevalenceofsicklecelldiseaseapproachedorexceeded1·0%infourregions,whichishigherthanpredictedwhenbasedonWiththegreatest burdenexistinginSub-SaharanAfrica,where%oftheworldsicklecelldiseaseoccurs[]"ASickleCellFreeUganda"MissionStatementThecalculated prevalenceofsicklecelltraitanddiseaseinnewbornsinthenineregionsofnorth-westernUnitedRepublicofTanzaniaistwiceashighaspreviouslyreportedand reinforcestheneedforenhancedSicklecelldiagnosticservicesBackground:Thefirstsurveyonsicklecelldisease(SCD)doneinUgandain,reportedthedistrict ofBundibugyoinWesternUgandatohavethehighestsicklecelltrait(SCT)prevalence(45%)