Pharmaceutical Excipients Used in Tablets and Capsules The FDA says excipient as a stable ingredient deliberately added to therapeutic and diagnostic products, which are not intended to exert therapeutic effects at the intended dosage, but which may allow to increase product delivery (e.g., improve absorption or key release of the drug substance).
Tablet manufacturing In the pharmaceutical manufacturing industry, tablet manufacturing is a composite method of making forms of solid pharmaceutical dosage. Packaging of solid pharmaceutical dosage another complicated processes. Meanwhile, unit pharmaceutical dose packaging has emerged as the most special form. For tablet formulation/compression and tablet manufacturing require special skill because which are required to be both pharmaceutically and therapeutically equivalent to a reference listed drug because the size and shape of the tablets may impact a patient’s ability. Roles of Excipients Excipients have different roles in a formulation/compression. Some of the major ones Roles of Excipients: 1. 2. 3. 4. 5.
Aid in the processing of the drug delivery system during its manufacture Protect, support, or enhance stability, bioavailability, or patient acceptability, Assist in product identification, and enhance any attribute of the overall safety Assist in the effectiveness and/or delivery of the drug in use Assist in maintaining the integrity of the drug product during storage
Selecting the Appropriate Excipient The purpose of pharmaceutical formulation development is to ensure that the drug is safe, effective, stable, and convenient to use. Excipients are an integral part of pharmaceutical products, general term for other materials in preparations except for the main drug, and are an important part of pharmaceutical preparations. Choosing of one or some right excipients for a drug formulation is a main step in drug manufacturing. The right excipients can reduce the manufacturing costs by being multifunctional, or may enhance patient. Excipients can be selected according to the uniqueness of the dosage form and the needs of the direction of drug administration. The right excipient for pharmaceutical formulation contains the ideal pharmacokinetic properties for your intended pharmaceutical application. The right excipient will also work well with your existing equipment or fit into your manufacturing plan.
For all these highly specialized works, there is always a solution. Several Excipient manufacturers, including those who work contracts, are specializing in different procedures of this industry. Some of them are equipped for custom formulation, packaging, and labeling.