61. Inhibition of ETS by Antimycin A
Quick Notes • • • •
One of the important known inhibitors of the ETC. It is an antibiotic produced by Streptomyces griseous that has been used as a piscicide for the control of some fish species. Antymicine A interferes with electron flow from cytochrome bH in Complex III (Qcytochrome c oxidoreductase). In the presence of this substance, cytochrome bHcan be reduced but not oxidized, consequently, in the presence of antimycin A cytochrome c remains oxidized, as do the cytochromes a and a3 that are ahead.
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