DLD
COG5 107,250,260
DLD
rs12672634
rs3779495
rs7779923
C/T
A/G
C/T
C/T
0.159 (0.015)
-0.318 (0.026)
0.111 (0.019)
0.144 (0.017)
Beta (SE)
1.57x10
1.50x10-17
5.91x10 2.85x10-14
-17
WB
WB
SM
7.84x10
-22
2.31x10
1.18 (0.99 - 1.41)
0.96 (0.78 - 1.20)
1.19 (0.99 - 1.42)
1.16 (0.97 - 1.39)
Liver
7.08x10
-7
-5
Tissue OR (95% C.I.) -10
Q
Fatty lesion
-12
1.64x10
P
Alleles STAGE eQTL analysis
0.063
0.742
0.067
0.093
P 0.159 0.208 8.45x10 0.142
0.99 (0.97 - 1.01) 0.99 (0.97 - 1.01) 1.04 (1.02 - 1.06) 0.99 (0.97 - 1.00)
-4
P
OR (95% C.I.)
CAD
eQTL
meQTL, eQTL, CAD
eQTL
eQTL
Assoc.
Per variant the effect and other allele (Alleles) and the effect allele frequency (EAF) are given. For each associated CpG the chromosomal (Chr) base pair position (BP) as well as the effect size (β) ± standard error of the mean (s.e.m.) with its associated p-value (P) and false-discovery rate (Q) is given. The CpG location indicates the position of the CpG relative to the gene(s). Also indicated for each variant are the odds ratio (OR) with the 95% confidence interval (95% C.I.) and the p-value of association with fatty lessions and CAD (from CARDIoGRAMplusC4D16). The last column (Assoc.) indicates which associations were found for this variant.
107,540,244
107582323
107,522,867
DLD
rs756382
BP
Gene
Variant
Table 4. 7q22 regional association of variants with gene expression in 7 tissues in STAGE.
CVD LOCI ASSOCIATE WITH PLAQUE CHARACTERISTICS
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4