Lucas (left) with Sachin Gupta Ph.D., M.B.A. (right), and Santas Rosario checking endothelium-derived KSHV-infected cells under the microscope.
“I’m going to do my best to help patients by combining my medical and scientif ic backgrounds.â€? to suppress the PDGFRÄŽ signaling, and found that there was a VLJQLĂ€FDQW UHGXFWLRQ LQ WXPRU JURZWK ZLWK NAC DQG IPDWLQLE TKH RQO\ FDYHDW WR WKH IPDWLQLE H[SHULPHQW LV WKDW IPDWLQLE DIIHFWV DOO WKH PD*FR VXEW\SHV TR SURYH WKDW IPDWLQLE LQKLEsg.mededu.miami.edu/medicalibis
ited oncogenesis only through the PDGFRĎ SDWKZD\ LXFDV SHUIRUPHG WDUJHW YDOLGDWLRQ KH KDUYHVWHG WKH WXPRUV DQG SHUIRUPHG :HVWHUQ EORWV WR GHWHUPLQH WKH SURWHLQ OHYHOV RI activated PDGFRĎ TKH GDWD VKRZHG D UHGXFWLRQ LQ PD*FRĎ, indicating that the PDGFRĎ needs to be activated in KS. LXFDV ZDV VWLOO XQVDWLVÀHG ZLWK MXVW SURYLQJ WKH LQYROYHment of PDGFRĎ E\ XVLQJ D GUXJ WULDO TR FRQFOXVLYHO\ YHULI\ the driving pathway was PDGFRĎ LXFDV GHYLVHG D JHQHWLF H[SHULPHQW LXFDV DQG KLV DVVRFLDWHV JHQHWLFDOO\ FUHDWHG .SHV infected cells that expressed a non-functional PDGFRĎ, called a dominant negative PDGFR Ď PXWDQW TKLV PXWDWLRQ ZRXOG NQRFN RXW RQO\ RQH VWHS LQ WKH LQWUDFHOOXODU VLJQDOLQJ FDVFDGH PDNLQJ LW D PRUH VSHFLÀF H[SHULPHQW WKDQ WKH IPDWLQLE DQG NAC WHVWLQJ LXFDV IRXQG WKDW WKH GRPLQDQW QHJDWLYH PD*FRĎ mutant failed to produce tumors. B\ DIIHFWLQJ RQO\ RQH JHQH LQ WKH KRVW LXFDV KDG QHDUO\ completely inhibited oncogenesis, which supports the hypothesis that PDGFRĎ SDWKZD\ LV RQFRJHQLF LQ .S BHFDXVH RI KLV ZRUN PDQNLQG QRZ KDV D VSHFLÀF SKDUPDFRORJLF WDUJHW LQ WKH ÀJKW DJDLQVW .S LXFDV KRSHV WR ORRN IRU PRUH SRWHQW VPDOO PROHFXOH GUXJV WKDW ZLOO EH PRUH HIIHFWLYH LQ EORFNLQJ the PDGFRĎ SDWKZD\ DQG WKXV KHOS WR GHYHORS VSHFLÀF DQG more effective anti-KS drugs. Spring 2014 | The Medical I.B.I.S.
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