Regulations of Pancreatic Juice Secretions The nervous and endocrine systems regulate the release of pancreatic juice. Nervous Regulation Parasympathetic impulses stimulate the secretions of digestive enzymes Endocrine Regulation Secretin • Stimulates the secretion of alkaline pancreatic juice with few enzymes. • Secretin is released when acidic chyme enters the duodenum. • Bicarbonate ions in the pancreatic juice neutralize the chyme. Cholecystokinin (CCK) • CCK stimulates the secretion of pancreatic juice rich in digestive enzymes. • It also stimulates the release of bile from the gall bladder. • CCK is released when chyme containing fats and proteins enters the small intestine.