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Advanced RCC
GIST
Pancreatic NET
2006
2006
2011
Years above denote TGA approval. PBS Information: RCC and GIST. Authority required. Refer to PBS Schedule for full authority information. Pancreatic NET. This indication is not listed on the PBS.
BEFORE PRESCRIBING, REFER TO THE FULL PRODUCT INFORMATION AVAILABLE AT WWW.PFIZER.COM.AU MINIMUM PRODUCT INFORMATION. SUTENT® (sunitinib 12.5 mg, 25 mg and 50 mg as malate) Capsules. Indications: Advanced renal cell carcinoma (RCC); gastrointestinal stromal tumour (GIST) after failure of imatinib mesylate treatment due to resistance or intolerance; unresectable, well-differentiated pancreatic neuroendocrine tumours (pancreatic NET). Contraindications: Hypersensitivity to sunitinib malate or excipients. Precautions: Haemorrhage, neutropenia, thrombocytopenia, decreased left ventricular ejection fraction, pre-existing cardiac conditions, prolonged QTc interval, hypertension, thyroid dysfunction, pancreatitis, hepatotoxicity, impaired wound healing, osteonecrosis of the jaw, tumour lysis syndrome, pregnancy, lactation, CYP3A4 inhibitors or inducers. See full PI for details. Adverse Effects: More common – fatigue, diarrhoea, nausea, vomiting, hypertension, bleeding, mucositis, skin abnormalities including hand-foot syndrome and change in hair & skin colour, altered taste. See full PI for details. Dosage and Administration: For RCC and GIST, 50 mg daily for 4 weeks followed by 2 weeks off (6 week cycle). For pancreatic NET, 37.5 mg daily. See full PI for details. PBS dispensed price, January 2012: SUTENT 12.5 mg: $1834.20; SUTENT 25 mg: $3521.76; SUTENT 50 mg: $6897.44. Reference. 1. SUTENT Approved Product Information. Pfizer Australia Pty Limited, ABN 50 008 422 348. www.pfizer.com.au Medical Information: 1800 675 229. SUTENT® is a registered trademark of Pfizer. Copyright © 2012. All rights reserved. P5700 01/12 PON0195/VMC
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