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The Kilkenny Observer Friday 13 May 2022
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Science & Wellbeing Medical and scientific research has never been as advanced as it today, especially when it comes to finding better treatments and, indeed, cures for cancers. Cancer is one of the world’s biggest killers, leading to 10 million deaths in 2020. But scientists are using artificial intelligence, DNA sequencing, precision oncology and other technologies to improve treatment and diagnosis of the disease. Breakthroughs include the DNA sequencing of more than 12,000 cancer tumours and a new test for diagnosing pancreatic cancer – one of the deadliest cancers. Cancer killed nearly 10 million people in 2020 and is a leading cause of death globally, according to the World Health Organisation (WHO). Breast cancer, lung cancer and colon cancer are among the most common cancers. Death rates from cancer were falling before the pandemic. Now COVID-19 has caused a big backlog in cancer diagnosis and treatment. But medical advances are continuing to help the world fight cancer. Here are some recent developments. Precision oncology Precision oncology is the “best new weapon to defeat cancer”, the chief executive of Genetron Health, Sizhen Wang, says in a blog for the World Economic Forum. This involves studying the genetic makeup and molecular characteristics of cancer tumours in individual patients. The precision oncology approach identifies changes in cells that might be causing the cancer to grow and spread. Personalised treatments can then be developed. Because
Winning the war on cancer precision oncology treatments are targeted – as opposed to general treatments like chemotherapy – it can mean less harm to healthy cells and fewer side effects as a result. In India, World Economic Forum partners are using emerging technologies like artificial intelligence (AI) and machine learning to transform cancer care. For example, AIbased risk profiling can help
to screen for common cancers like breast cancer, leading to early diagnosis. AI technology can also be used to analyse X-rays to identify cancers, in places where imaging experts might not be available. These are two of 18 cancer interventions that The Centre for Fourth Industrial Revolution of the World Economic Forum India hopes to accelerate.
Hospitals have sequenced the DNA of more than 12,000 cancer tumours to reveal new clues about the disease. At Cambridge University Hospitals in England, the DNA of cancer tumours from 12,000 patients is revealing new clues about the causes of cancer, scientists say. By analysing genomic data, oncologists are identifying different mutations that have contributed to each
person’s cancer. For example, exposure to smoking or UV light, or internal malfunctions in cells. These are like “fingerprints in a crime scene”, the scientists say – and more of them are being found. “We uncovered 58 new mutational signatures and broadened our knowledge of cancer,” says study author Dr Andrea Degasperi, from Cambridge’s Department of Oncology.
Biopsies are the main way doctors diagnose cancer – but the process is invasive and involves removing a section of tissue from the body, sometimes surgically, so it can be examined in a laboratory. Liquid biopsies are an easier and less invasive solution where blood samples can be tested for signs of cancer. Synthetic biopsies are another innovation that can force cancer cells to reveal themselves during the earliest stages of the disease. A treatment that makes immune cells hunt down and kill cancer cells was recently declared a success for leukaemia patients. The treatment, called CAR-T-cell therapy, involves removing and genetically altering immune cells, called T cells, from cancer patients. The altered cells then produce proteins called chimeric antigen receptors (CARs). These recognise and can destroy cancer cells. In the journal Nature, scientists at the University of Pennsylvania announced that two of the first people treated with CAR-T- cell therapy were still in remission 12 years on. nature Pancreatic cancer is one of the deadliest cancers. It is rarely diagnosed before it starts to spread and has a survival rate of less than 5% over five years. At the University of California San Diego School of Medicine, scientists have developed a test that was able to identify 95% of early pancreatic cancers in a study. The research, published in Nature Communications Medicine, explains how biomarkers in extracellular vesicles – particles that regulate communication between cells – were used to detect pancreatic, ovarian and bladder cancer at stages I and II.
Imagine doing nothing at all, absolutely zero Bet ye didn’t know this, but one of the most popular behaviours or pastimes down through history has been doing nothing at all. Absolutely nothing. Nowt. Zero. The Greeks, in particular, excelled at it. We seem to have forgotten how to perform or do nothing. The closest we come to it these days is sleeping or resting. But when was the last time you did absolutely nothing? When was the last time you stared out of a window for a long period of time? Can you remember the last time you sat in a park and just looked around? Have you ever just laid on your back and looked deep into the sky? We live in a world where something is expected of us every moment. Either we’re working, socialising, cooking, cleaning, eating, drinking, travelling, scrolling through social media, or watching Netflix We’re always going somewhere or trying to get something. We live in a culture that abhors doing nothing which is evident in our frantic work
schedules and constant need to be entertained. Imagine if you had the monk-like peace of mind to just put a stop to all of the doing and lived completely in what Eckhart Tolle calls
‘The Now’. Seems impossible, right? In the ‘Tao Te Ching’ philosopher Lao Tzu challenges people to balance all of the something they’re constantly up to by also learning to
embrace the nothing. “When nothing is done, nothing is left undone,” the philosopher famously said. Dr Manvir Singh, a research fellow at the Institute for Advanced Study in
Toulouse and a Ph.D. from Harvard’s Department of Human Evolutionary Biology, called attention to our inability to do nothing on Twitter recently. Dr Singh shared a tweet
thread that highlighted a study from the ‘70s and ‘80s in small-scale non-industrial societies where researchers noted activities people engaged in throughout the day. The shocking fact — at least from today’s perspective — is that idling or “doing nothing” was one of their favourite activities. In the 1970s and ‘80s, anthropologists working in small- scale, non-industrial societies fastidiously noted down what people were doing throughout the day. The anthropologists visited random people during waking hours and recorded what they were doing, building a representative sample of time use. Most of these data were collected while an anthropologist lived with the community for a year. The researchers typically chose among 60 activity codes, one of which was ‘Idle, doing nothing’. This is different from napping, chatting, fixing tools, tidying up, and idleness because of illness. As far as we can tell, it’s really about doing nothing at all, at least apparently.
