A P P E N D I C E S

APPENDIX 1 ...56

List of McKnight Affiliate Faculty and Trainees

APPENDIX 2 ...63

Top 20 Publications from FY22

APPENDIX 3 ...67

Presentations at scientific or public meetings

APPENDIX 4 ...73

Highlights of website development, media coverage and/or social media audience development

APPENDIX 5 ...87

Update on McKnight Neurocognitive Scholar Christian Agudelo, MD

Dear Trustees:

Please find enclosed the University of Miami Evelyn F McKnight Brain Institute Annual report As I reflect on 2022, I am proud of many things that demonstrate the maturing and expansion of our EMBI. If you visit our website at https://mbi-umiami.org and our social media pages, you will understand that our EMBI umbrella has grown in its coverage of cognitive clinical and translational research in all divisions in the Department of Neurology and the brain health and cognitive programs at the University of Miami Miller School of Medicine.

In 2022, the Department of Neurology at the University of Miami was ranked #25 in the US News and World Report in the Neurology and Neurosurgery specialty and, even more impressive, #18 in NIH funding Our EMBI continues to develop scientific programs according to our strategic plan and continues to offer a broad range of clinical and research training opportunities to clinical and translational trainees and researchers Led by Dr Rundek as the scientific director and the Evelyn F McKnight Chair for Learning and Memory in Aging, our EMBI focuses and offers a wealth of knowledge in clinical translational research, education, and mentorship, and provides neurocognitive research opportunities, all that are detailed in the report I am happy to confirm that Dr James Galvin, who is a world-renowned cognitive neurologist and researcher has started as the Chief of the Cognitive Division and has expanded the Comprehensive Center for Brain Health’s (CCBH) research and outreach into the in Boca Raton/Palm Beach community Our EMBI works closely with CCBH on clinical research and research mentoring, and clinical education and training in cognitive aging and brain health.

We continue our successful work on the integrative and collaborative programs with the Center for Neurocognitive Sciences and Aging led by Dr. David Loewenstein in the Department of Psychiatry. We have also extended our collaborations across the University, particularly through our Clinical Translational Science Institute (CTSI) and institutional neuroscience and aging collaborative programs and initiatives under leadership of Drs. Rundek, Loewenstein and Galvin in collaboration with the Department of Neurosurgery, Miami Project to Cure Paralysis, Center for AIDS Research (CFAR) and others Our collaboration with other EMBIs is strong We supported our Inter-institutional meeting this year and traveled to Arizona to attend the meetings in-person We work collaboratively on large projects with UA and on other grants and pilots with UF and UAB Our collaborations with other national institutions and partners is also strong We continue our research collaborations and programs with Columbia University, Albert Einstein in New York, University of Chicago, USCD, Harvard, and established new partnerships such as with University of Louisville We are partners with the AHA, AAN, and other professional and scientific organizations and NIH networks, including NeuroNEXT, StrokeNet, and ADRC.

Dr. Rundek continues her work as the main PI for research training and education for the 1FL ADRC. She co-directs the 1FL ADRC AlzSTARS (Alzheimer's Disease Science Training to Advance Research Success) program together with Dr Glenn Smith at UF As Director of NIH StrokeNet and NeuroNEXT Training programs as well as of CTSI Kl2 program and MS in Clinical Translational Investigations, Dr Rundek is a key mentor to trainees in these programs Our mentees obtained K and K-like grants We expect more success as Dr Rundek has just received funding for a T32 in collaboration with Dr Jean-Louis in the Department of Psychiatry and submitted two additional T32s and a R25 with aging and neuroscience focus

Our strategic plan is entering the third year We are ahead in accomplishing our strategic goals in research, education, collaborations and community outreach. We are dedicated to our DIRECT (Diversity, Integrity, Responsibility, Excellence, Creativity, Teamwork) values. Our EMBI team is strong, cohesive, effective, and collaborative and is a role model for any collaborative research team.

Challenges however remain, while Covid has allowed us to reach many patients and research participants without Miami travel issues, the in-person portion of some studies continues to be limited. Together with Dr. Baumel and now with Dr. Galvin, our clinical and educational activities will continue to grow with the opportunities to recruit at least two more cognitive neurologists and train a strong team of clinical cognitive neurologists-scientists Our current neurocognitive team has provided virtual care for more than 2,000 patients this year

In 2023, we will continue our leadership in research, training and mentorship of the next generation of successful cognitive physician-scientists by recruiting another Evelyn F McKnight Neurocognitive Clinical Scholar in Brain Health and Aging as part of our postdoctoral training program With Drs Rundek, Sun, Levin, and Galvin, along with all existing EMBI faculty and EMBI Scientific Advisory Board members, the University of Miami EMBI and the Department of Neurology will continue its unique cognitive aging and memory clinical translational program and continue to advance research in age-related memory loss and cognitive decline and brain health through new programs, grants and other multi-disciplinary collaborations and partnerships. Finally, in January of 2023 the Alexandria and Bernard Schoninger Chair in Memory Disorders will be awarded to Dr. Galvin.

As I battle my health issues, I feel confident that our EMBI is in the capable hands of our team under leadership of Dr. Rundek, who has my full support as well as the support of our Institution, Dean Ford, our Scientific Advisory Board, and the leaders of the other EMBIs

Thank you for your continued support and collaboration in our efforts

Warmest regards, Ralph L. Sacco MD, MS, FAHA,

Dear Trustees:

As I reflect on 2022, I am proud of my 5th year co-leadership of the EMBI at the University of Miami Department of Neurology. Our EMBI continues achieving the objectives in all areas of our strategic plan goals: research, education, collaborations, and community outreach. We innovate and continue to extend our collaborations within our Institution, with other EMBIs, and with institutions nationwide. Our EMBI team is effective, collaborative, productive, and continuously strives to improve and advance our mission. We openly communicate and share our EMBI activities and results at multiple forums, from our weekly administrative and research meetings, to monthly seminars and journal clubs, clinical and research training programs and community outreach through social media and educational events. As a matured organization our formal Scientific Advisory Board meets formally twice a year, but also convenes at Dean’s team science research meetings, and Clinical Translational Science Institute collaborative neuroscience activities

We have advanced almost all our four strategic goals for 2022: (1) Continue development of our scientific programs directly related to our EMBI and the McKnight Brain Research Foundation mission Our new NIH grants and the Comprehensive Center for Brain Health (CCBH) led by Dr James Galvin continues the expansion of our research and scientific programs; (2) Continue clinical translational education and mentorship Dr Christian Agudelo, Michael Kleiman and Anita Saporta are advancing this goal together with Taylor Ariko, our PhD student in medical bioengineering, who will advance machine learning algorithms for the assessment of neuroimaging and cognitive phenotypes; (3) Promotecommunicationsand collaborations. We have significantly advanced our EMBI branding, established our EMBI logo and participated in several collaborative inter-institutional projects; and (4) Develop community outreach. We have been on the frontiers of social media outreach in our community and the leaders in virtual social and education events. We plan to continue with this major focus in 2023. I am also extremely proud of our exemplary EMBI research administrative team, Susan Fox-Rosellini, Stacy Merritt, and Marti Flothmann, who continue improving our web, social media development, and our community outreach.

In November 2022, I was elected to the Academy of Science, Engineering and Medicine in Florida (ASEMFL), a great honor which will expand my collaborations across the State of Florida and facilitate my engagement in discussions about research and global challenges our society faces I continue as President of the Intersocietal Accreditation Commission (IAC) Vascular Testing Board of Directors, the largest national accreditation body that accredits clinical nuclear/PET, MRI, CT, ultrasound, cardiac echo, and carotid stenting programs We have increased the number of accredited vascular testing facilities, particularly in neurovascular testing services, and through accreditation and research improved care for patients with vascular cognitive impairment (VCI).

We have published a seminal IAC paper on the revised criteria for carotid stenosis that are now being adopted by many institutions as a new standard of care in their clinical practice for patients with carotid atherosclerotic disease, stroke and VCI.

This year was again full of achievements, but also challenges. In the first part of a post-Covid 2022 environment, we continued to be concerned for the health of our team members, patients and study participants Despite these issues, our programs have successfully continued and thrived, and our team members were encouraging and supportive of all of our EMBI members, collaborators, study participants, trainees and the community we serve

In our report and in this letter, we highlight our achievements, from numerous training and research grants submitted and received, to educational and training activities, success of our EMBI scholar and other trainees, community outreach and numerous established collaborations and new initiatives within our institution, with other EMBIs, and across institutions nationwide Among our most notable, is a renewal application of our CTSI in September, where I led the submission of CTSI K12 program as a Director. I have submitted six training grants to NIH as MPI (three T32s, one R25, NeuroNEXT and FL DOH fellowship); one T32 and FL DOH just received funding, one would need to be resubmitted and others are pending reviews. I have also submitted several collaborative NIH grants, which are pending review. It has been an intensive grant writing period and it will continue in 2023!

In 2023, I am committed to continue guiding the execution of our strategic plan, advancing our scientific and education mission, and advancing our training and mentorship In addition, I will continue advancing the Research Educational Core for the 1FL ADRC AlzSTARS (Alzheimer's Disease Science Training to Advance Research Success) program, which now has 8 trainees; 2 of which are from our EMBI, Magda Tolea and Regina Vontell In our collaborative and successful NIA award Precision Aging Network (PAN) led by Dr Barnes, I have taken a co-lead role of the PAN2 clinical project with Dr Lee Ryan We had a successful PAN startup year We prepared all regulatory and study documents, obtained IRB approval, prepared SOPs, and trained research teams in all procedures and data collections for a complex 2-day study visit protocol As a lead of the PAN2 Neurosonology Core in Miami, we completed in-person training sessions of all PAN sonographers from Emory, Johns Hopkins and U Arizona, in Miami, and certified them for performance of the standardized ultrasound scanning protocols.

To further advance our strategic programmatic development, I will continue to develop collaborations with other Centers and Institutes at UM as well as other EMBIs. This includes strong collaborations with the Cognitive Division and Comprehensive Center for Brain Health led by Dr. Galvin, who was appointed the new Director of our Cognitive Division this year. Our collaborations will continue with Center for Neurocognitive Sciences and Aging (Dr. Loewenstein), Hussman Institute for Human Genomics (Drs Pericak-Vance and Blanton), and Clinical Translational Science

Institute (CTSI) and Neuroscience program I will continue to be a senior leader of CFAR Scientific Working Group on Aging in HIV and serve on the CFAR Steering Committee I will also closely work with our Education Director Dr Sun on advancing our education mission and recruiting the best candidates for the Evelyn F McKnight Neurocognitive Clinical Scholar in Brain Health and Aging in 2023/2024

Finally, our EMBI is delving into several new and exciting research areas including, Neighborhood Greenness and Cognitive Performance, that was recently funded by NINDS and for which I serve as a MPI, Sleep in Neurocognitive Aging and Alzheimer’s Research (SANAR) led by Dr. Alberto Ramos that was just funded, a new study on cardiac determinants of cognitive health recently submitted to NIH in collaboration with Columbia University, four new federal grant research projects awarded to Dr. Galvin, and other grants, projects and research activities.

I am looking forward to another exciting and productive year for our EMBI.

Warmest regards, Tatjana Rundek, M D , Ph D

Scientific Director

Dear Trustees:

It has been a great pleasure to serve as the Education Director of the Evelyn F McKnight Brain Institute (EMBI). On behalf of the EMBI Education Program at the University of Miami Miller School of Medicine, I am pleased to present a summary of the educational activities organized at our institute in 2022.

Under the leadership of Dr. Sacco and Dr. Rundek, our EMBI educational program continued to play a vital role in providing education for the entire EMBI, in cultivating young scientists, physicians and students for their career development and research in aging and cognitive neurology as their career choice. We focused our efforts on reaching the diverse communities of South Florida to provide education on brain wellness in the aging population

General EMBI Education

We are committed to creating a nurturing learning environment for our neurology staff, graduate students, residents, fellows, and faculty at EMBI We organized a diverse range of research seminars, journal clubs, and brain cutting sessions for EMBI members, collaborators and trainees

Our educational activities were well attended and highly evaluated for relevance, impact and innovation We arranged presentations for our trainees giving them opportunities to hear feedback on their research projects and to improve their research and presentations skills as well as academic achievement outcome. We have supported our faculty and trainees by providing targeted research training in their specific interests and disciplines. We encouraged faculty and trainees to enroll in various workshops such as those offered through the CTSI (Clinical Translational Science Institute), including the research mentoring training program and grant writing workshops.

EMBI Training Program

One of our important missions in our EMBI is to support career development in cognitive neuroscience for the next generation. To provide individual training opportunities, we have focused on obtaining grants poised to recruit additional post-doctoral trainees as well as to fund current trainees and junior faculty Dr Rundek applied for and was awarded 2 training grants (T32 and FL DOH fellowship), which will facilitate the growth of our training program goal to increase the number of scientists and clinicians trained in aging and cognition Our EMBI faculty serve as educators and mentors for trainees with impressive grant portfolios including, an R25, K24, T32, Florida DOH, NIH and 1 Florida ADRC Center grants EMBI trainees are actively applying for F, K and R awards as well as other K-like foundation awards (e g American Heart Association, American Academy of Neurology, National Science Foundation and others)

EMBI Community Outreach Program

This year we strived to provide outreach and education with the goal of maintaining and improving brain health in the aging population. We reached both Hispanic and non-Hispanic community members in Monroe, Dade, Broward and Palm Beach Counties. We worked with our current aging organization partners and continued to make new partnerships. We organized our Lecture Series for the fourth year with the Miami-Dade Public Library System and received overwhelmingly positive feedback with many requests for more series like this.

In 2023, we will increase our scope of EMBI education programs in-house and in the community. We will continue to organize seminar series, journal clubs, and brain cutting sessions. We plan to organize targeted research seminars to facilitate grant application and collaboration across institutes. We plan to recruit excellent candidates to be trained in cognitive neurology and neuroscience. Our focus will continue on obtaining post-doctoral training grants to satisfy the need for clinicians and scientists who can effectively and efficiently translate science into practice in the field of normal brain aging and Alzheimer’s and Alzheimer’s related disorders (AD/ADRD) for our rapidly growing aging population.

In 2023, I am planning to take a more prominent role in our Endowed Brain Bank. I will extend our education and research activities to include more brain pathology and neuroscience education for our trainees in neurology and psychiatry. I will also work with Dr. Rundek on identifying an EMBI Associate Education Director, who will help extend our education activities and who will be mentored to be my successor as I transition to a position of Director of Brain Bank in the next several years.

Thank you for your continued support and collaboration in our education and training efforts.

Warmest Regards, Xiaoyan Sun, MD, PhD