New Grants for EMBI Faculty

from EMBI Annual Report 2022

N e w G r a n t s f o r E M B I T r a i n e e s

Dr. Rundek received funding for these submissions in 2022

Dr. Rundek’s training grant submission to the Florida DOH Ed and Ethel Moore Alzheimer’s Disease Research Program was funded in the amount of $100,000 00 The training project TRANSlational Fellowship Opportunity for Research on Multimorbidity in Alzheimer’s Disease: TRANSFORM-AD will aim to increase the number of diverse AD/ADRD investigators-leaders in cross-disciplinary clinical translational research, who can effectively and rapidly translate, implement, and disseminate discoveries to practice and community, and to address the special health challenges and health disparities of the diverse AD/ADRD patients we serve through team science and collaborations with community partners and diverse health care stakeholders.

Dr. Rundek’s collaborative T32 training grant study PINNACLE was funded (Role: Co-I). Details on page 31.

Drs. Loewenstein and Rundek (Co-Investigators) received an R01 grant to study Innovative Deep Phenotyping of African Americans (AA) at Risk for Alzheimer's disease. Details on page 51.

The UM CFAR funding was renewed for five years (Role: Senior Investigator and Steering Committee member) Details on page 32

Dr. Rundek as a Co-I received an NIA R01 titled Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease Details on page 46

Dr. Galvin received 4 new NIH awards this year

NIH R01 supplement award to study Retinal Amyloid Imaging with our EMBI collaborators Drs. Jiang & Wang. The major goals of this project are to develop, validate and test retinal amyloid imaging using confocal scanning laser ophthalmoscopy and optical coherence tomography in a longitudinal study of ADRD biomarkers in a deeply phenotyped multicultural sample of older adults. Role: PI

NIH/NIA R01to research A Phase 2b Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients with Mild-to-Moderate Dementia with Lewy Bodies. The major goal of this project is to conduct a Phase 2b clinical trial of Neflamapimod, a novel disease-modifying compound, in patients with mild to moderate dementia with Lewy bodies. Role: MPI.

NIH/NIA RF1 Alzheimer’s Disease and Related Dementias (ADRD) Prevalence in American Samoa. The major goals of this project are to assess ADRD health literacy and research readiness, establish the prevalence of mild cognitive impairment and ADRD, and study genetic and plasma ADRD biomarkers Role: MPI

NIH/NIA R56 Deep Phenotypic Characterization of Prodromal Dementia with Lewy Bodies The major goal of this study is to model prodromal DLB using deep phenotyping and describe the risk of conversion to clinical symptomatic stages of disease in order to increase accurate and early diagnosis, develop therapeutic targets, and improve health outcomes in DLB Role: PI

Dr. Sun received an award as a Co-Investigator to study the Neural Network Connectivity of Autobiographical Music in Adults with Mild Cognitive Impairment and Mild Alzheimer’s Disease from the Lee Peach Foundation This is the basis of her newest partnership with the UM Frost School of Music

Dr. Davis was awarded the following grants in 2022.

Herbert W. Hoover Foundation: Detecting Nanoplastics in the Olfactory Pathway: A Feasibility Study Role: PI

NIH NINDS - Single-nucleus Transcriptome Profiling Across Multiple Brain Regions in Parkinson's Disease Role: Co-I

U S Department of Veterans Affairs - The National Posttraumatic Stress Disorder Biorepository Brain Role: Co-I

NIH NINDS - The NIH Brain and Tissue Repository Role: Co-I

Dr. McIntosh received a Center for AIDS Research (CFAR) Small Pilot Program grant to study Geriatric Resilience Informed by Precision Selection (GRIPS) Role: PI; Co-Investigator: Dr. Levin

Dr. Bracko received three grant awards this year:

One was an R21 from the NIH for Investigating the cause of cerebral blood flow reductions in a mouse model of frontotemporal dementia.

Another was an AARG grant from the Alzheimer’s Association to research Single-cell analysis of neutrophil subpopulations and their contribution to vascular inflammation in mouse models of Alzheimer’s disease

The third was a Provost's Research Award for the role of neutrophils in microvascular dysfunction in mouse models of Alzheimer’s disease