State of the School Presentation by UAB School of Medicine

State of the School Selwyn M. Vickers, M.D., FACS Senior Vice President for Medicine Dean of the School of Medicine January 29, 2020

IN MEMORIAM

Mark Pritchard, Ph.D.

Ralph Samlowski, Associate M.D.

Raymond Sheppard, Sr., M.D. Assistant

Professor

Assistant Professor

Family Medicine

OB/GYN

Surgery

Huntsville RMC

Jay McDonald, M.D.

Professor

Former Chair

Pediatrics

Professor Emeritus Pathology

SCHOOL OF MEDICINE

Beverly Chaignaud, M.D.

LEADERSHIP ACKNOWLEDGEMENT

Ray L. Watts, M.D. President, UAB

UAB named ‘#1 Young University’ 2nd year in a row and celebrated 50th anniversary

SCHOOL OF MEDICINE

UNIVERSITY LEADERSHIP

Pam Benoit, Ph.D. Senior Vice President for Academic Affairs and Provost

SCHOOL OF MEDICINE

Christopher S. Brown, Ph.D. Vice President for Research

BUILDING ON A SUCCESSFUL PARTNERSHIP

Selwyn M. Vickers, M.D., FACS Senior Vice President for Medicine

William Ferniany, Ph.D. CEO, UAB Health System

Dean of the School of Medicine

SCHOOL OF MEDICINE

PHYSICIAN LEADERSHIP

Keith A. (Tony) Jones, M.D.

President, UAHSF Chief Physician Executive, UABHS Senior Associate Dean for Clinical Affairs, SOM

SCHOOL OF MEDICINE

LEADERSHIP CHANGES IN 2019

Steven Theiss, M.D. Named Chair of Orthopaedic Surgery

SCHOOL OF MEDICINE

Erik Hess, M.D., M.Sc. Named Interim Chair of Emergency Medicine

LEADERSHIP CHANGES IN 2019

Barry Sleckman, M.D., Ph.D. Named Director of the O’Neal Comprehensive Cancer Center

SCHOOL OF MEDICINE

THANK YOU

Ravi Bhatia, M.D. For serving as Interim Director of the O’Neal Comprehensive Cancer Center

SCHOOL OF MEDICINE

THANK YOU FOR YOUR SERVICE

Janyce Sanford, M.D., MBA Stepped down from

Jim MeadorWoodruff, M.D. Stepped down from

Amie McLain, M.D. Stepped down from

Chair of Emergency Medicine

Chair of Psychiatry for new role in UAB Health System

Chair of Physical Medicine and Rehabilitation

11 years of service as Chair

13 years of service as Chair

SCHOOL OF MEDICINE

ACTIVE LEADERSHIP SEARCHES

• Dean – Montgomery Regional Medical Campus • Chair – Department of Genetics • Chair – Department of OB/GYN

SCHOOL OF MEDICINE

PITTMAN SCHOLARS: UAB RESEARCH PIPELINE

Akila Subramania m, M.D. Obstetrics/ Gynecology

Ashley Harms, Ph.D.

Ceren YararFisher, Ph.D.

Sushant Bhatnagar, Ph.D.

Department of Neurology

Department of Physical Medicine and Rehabilitation

Department of Medicine

SCHOOL OF MEDICINE

Craig Maynard, Ph.D.

Department of Pathology

Summer Thyme, Ph.D. Department of Neurobiology

ENDOWED CHAIRS & PROFESSORSHIPS AWARDED IN 2019 13

Roslyn Berstein Mannon, M.D. Robert G. Luke, M.D., Endowed Chair in Transplant Nephrology Vineeta Kumar, M.D. Robert C. Bourge and Cutessa D. Bourge Endowed Professorship in Transplant Nephrology Edward W. Inscho, Ph.D. Endowed Professorship in Nephrology Cynthia J. Brown, M.D., MSPH Gwen McWhorter, Ed.D., Endowed Chair in Geriatric Medicine Rachel E. Fargason, M.D. Patrick H. Linton Professorship in Psychiatry Cristina Magi-Galluzzi, M.D., Ph.D., FCAP C. Bruce Alexander Endowed Professorship in Pathology Douglas R. Morgan, M.D., MPH SCHOOL OF MEDICINE Endowed Professorship in Gastroenterology and

Jose A. Tallaj, M.D. Bourge-McGiffin Endowed Professorship in Heart Transplantation Salpy V. Pamboukian, M.D., MSPH Bourge-Kirklin Endowed Professorship in Mechanical Circulatory Support Jayme E. Locke, M.D., MPH., FACS, FAST Mark H. Deierhoi, M.D., Endowed Professorship Gang Liu, M.D., Ph.D. Endowed Professorship in Lung Cellular and Molecular Biology Rosa A. Serra, Ph.D. UAHSF Endowed Chair in Cancer Biology Keith A. Jones, M.D. Maurice S. Albin, M.D., Endowed Professorship in Anesthesiology and Perioperative Medicine Lewis Keith Lloyd, M.D. Anderson Family Endowed Chair in Urology© UAB. All Rights Reserved.

ENDOWED CHAIRS & PROFESSORSHIPS Dan E. Berkowitz, M.B., BCh Alfred Habeeb Chair in Anesthesiology Marcas M. Bamman, Ph.D. UAHSF Endowed Professorship in Regenerative and Translational Medicine Suzanne Oparil, M.D. United Therapeutics Endowed Professorship in Pulmonary Vascular Disease Andre Ballesteros-Tato, Ph.D. J. Claude Bennett Endowed Professorship in Rheumatology and Immunology Hugh T. McElderry, Jr., M.D. G. Neal Kay Endowed Professorship in Clinical Electrophysiology Yabing Chen, Ph.D. Jay M. McDonald, M.D., Endowed Professorship in Laboratory Medicine Susan L. Bellis, Ph.D. Alma B. Maxwell-UAHSF Endowed Chair in Biomedical Research SCHOOL OF MEDICINE

Erik D. Roberson, M.D., Ph.D. Rebecca Gale Endowed Professorship in the Department of Neurology C. Ryan Miller, M.D., Ph.D. Translational Research Endowed Professorship in Pathology Alan Percy, M.D. Sarah Katherine Bateh Endowed Professorship for Rett Syndrome Talene Yacoubian, M.D., Ph.D. John A. and Ruth R. Jurenko Endowed Professorship in Neurology Jeremy H. Herskowitz, Ph.D. Patsy W. and Charles A. Collat Endowed Professorship in Neuroscience

SNAPSHOT

3,799

T O TA L S O M S TA F F

1,619 F U L L -T I M E F A C U LT Y

799

98%

MEDICAL STUDENTS

M AT C H R AT E

SCHOOL OF MEDICINE

N E W F A C U LT Y

1,057

RESIDENTS & FELLOWS

SNAPSHOT

1,500,888

125,065

51,910

UAB MEDICINE CLINIC ENCOUNTERS

# O F PAT E N T S BY S O M F A C U LT Y

ANNUAL ER VISITS AT UA B H O S P I TA L

H O S P I TA L S U R G I C A L CASES

SCHOOL OF MEDICINE

PHDS AWARDE D

91.31% H O S P I TA L O C C U PA N C Y R AT E

“

Yesterday’s home runs don’t win today’s game. -Babe Ruth

”

BUILDING ON THE LAST FIVE YEARS

SCHOOL OF MEDICINE

ADVANCE THE MISSION

RESEARCH

HOW DO WE BUILD ON THE LAST SIX YEARS Six-year growth of NIH grants >$100M (2013-2019) 100%

93%

92%

90%

87% 81%

80%

74%

70%

63%

60% 51%

50%

49%

45%

44%

41%

40%

40% 30%

30%

28%

20% 10% 0% 21

-U

AB w th or g - N ber 15 e i n F

r te es

ou -M

in tS

h ca i -I

-N

rk Yo

si er iv

ty 9

-C

bi um

-U

as W

g in

n to 8

-D

e 5

rd fo n a St 7

-P

r bu ti ts

gh 6

al -Y

-U

a Fr

i nc

o 10

-M

i ch

-U

n fe ef G A-

SCHOOL OF MEDICINE

-P

y ns

an m l re Pe a 2

-J

n oh

k op

NIH FUNDING GROWTH

• 2019 SOM total NIH funding: $256,395,438 • 9.4% growth year-over-year • Ranked #8 among public schools • Ranked #21 among all schools SCHOOL OF MEDICINE

Nearly all departments have experienced growth in NIH research dollars

TOP 25 - % CHANGE YEAR OVER YEAR

30.0% 25.0%

9.4%

20.0% 15.0% 10.0% 5.0% 0.0% -5.0% -10.0%

n e n y n ty rn an LA to or si go uk ah te g r C m e l c s m D n r U e e -I E ve hi O ai er s ni 8 hw n a P i t 3 U 0 9 u 1 S 2 2 W a 1 k i t 2 So Yor U an un T v o l U M ew nsy 2 15 N 3 n 2 12 Pe 17 3

n B ilt le ia is rn rg rd ns do co an na go b a i i b si u A u e o l r e a s g t f Y k i i n i o r b o U e m n s h c L s o D u e op ar co ta ic nd t. ol itt n 6 an ol w H C is S a 1 r S a P M C h C V 2 t F s W S th U n or 5 hn 7 U C or 4 0 n a 9 N 4 o 2 1 o N U S 1 J gt C in 25 8 16 U h 11 1 as 1 W 4

or yl a B

SCHOOL OF MEDICINE

MAJOR GRANTS

• Bruce Korf, M.D., Ph.D. - Southern All of Us Network, $67M/5yrs, Department of Genetics • Robert Kimberly, M.D. - Center for Clinical Translational Science, $49M/5yrs, Department of Medicine • Richard Whitley, M.D./The Antiviral Drug Discovery and Development Center (AD3C) Five-year, $37.5 million grant from the National Institute of Allergy and Infectious Diseases Centers of Excellence for Translational Research to study and develop treatment for high-priority infections • Frances Lund, Ph.D. - Mechanisms of Tissue and Organ Specific Human B Cell Immunity, $17.8M, Department of Microbiology

SCHOOL OF MEDICINE

MAJOR GRANTS

• David Kimberlin, M.D. - $10 million contract from The National Institute of Allergy and Infectious Disease to conduct a multicenter, multinational natural history study of acute flaccid myelitis, Department of Pediatrics • Michael Saag, M.D - Center for AIDS Research (CFAR) $7.5M grant renewal from the National Institute of Allergy and Infectious Diseases for HIV and related disorder research • Division of Infectious Diseases & CFAR - $7 million grant from Merck Foundation to address HIV disparities in the Southeast • Kenneth Saag, M.D., M.Sc. - Deep South Translational Research Mentored Career Development Program, >$5M, Department of Medicine SCHOOL OF MEDICINE

OUTSTANDING NIH INVESTIGATOR AWARDS

R35 Grant Recipients

Smita Bhatia, M.D. Mitigating long-term treatment-related morbidity in childhood cancer survivors

J. Edwin Blalock, Ph.D. A novel exosomal inflammatory pathway

SCHOOL OF MEDICINE

Michael Gray, Ph.D. Bacterial responses to reactive chlorine stress and their role in host-microbe interactions

Gang Liu, M.D., Ph.D Program on cellular metabolism and lung fibrosis

Steven Rowe, M.D., MSPH Translational program in CFTRrelated airward disease

THE AMERICAN SOCIETY FOR CLINICAL INVESTIGATION

Elected to the ASCI in 2019:

Erik Roberson, M.D., Ph.D.

Orlando Gutierrez, M.D. Medicine

Neurology SCHOOL OF MEDICINE

EDUCATION

ACADEMIC SUCCESS

The SOM Academic Success Program is working to strategically impact more students by: • Expanding the peer tutoring staff and involving them to create peer learning experiences • Soliciting faculty and student feedback to better address challenges in the curriculum/transition points • Piloting a pre-matriculation course for students who might benefit from early engagement • Developing an actionable, data-driven plan to expand the Step 1 advising program

4,369 students applied to the medical school last year, and 186 were matriculated: very competitive SCHOOL OF MEDICINE

INTERNATIONAL MEDICAL EDUCATION • Developed and fostered close to 20 programs that enable visiting scholars at varying degrees of academic levels to come to UAB for further training • International Visiting Medical Student (IVMS) Program hosted 124 students attending 160 different clinical electives • Sent 18 UAB medical students abroad through the Medical Student Enrichment Program for first and fourth years students who are interested in global medicine

SCHOOL OF MEDICINE

Majd Zayzafoon, M.D., Ph.D. Assistant Dean of International Medical Education

Medical students in Zambia

HUNTSVILLE REGIONAL MEDICAL CAMPUS

• The UAB Comprehensive Transplant Institute has opened a new clinic at the HRMC to better serve patients in North Alabama • The HRMC has opened a new psychiatric clinic to serve both adult and pediatric patients • Two new endowments were established: the William H. Coleman, Sr., M.D., Ph.D., Huntsville Family Medicine Endowed Professorship and the Lourdes C. Corman, M.D., FACP, Endowed Support Fund for Huntsville Outreach SCHOOL OF MEDICINE

Roger Smalligan, M.D. Dean

Drs. Coleman and Corman

MONTGOMERY REGIONAL MEDICAL CAMPUS

• Thanks to a generous philanthropic pledge from the Baptist Health Care Foundation, the MRMC is launching an Internal Medicine Integrated Residency Scholarship Program • UAB is currently completing a search for a new dean of the MRMC • MRMC has grown to 11 faculty members, 40 staff members and 82 students and residents SCHOOL OF MEDICINE

TUSCALOOSA REGIONAL CAMPUS

• In July 2019, Richard Friend, M.D., was named dean of the Tuscaloosa Regional Campus/College of Community Health Sciences • Added physicians specializing in family medicine, pediatrics, endocrinology, ob-gyn • Tuscaloosa has now admitted two classes of Primary Care Track students Richard Friend, M.D. Dean

• The Hybrid Longitudinal Integrated Clerkship is in its second year

SCHOOL OF MEDICINE

GRADUATE MEDICAL EDUCATION

• UAB currently has 1,000+ residents and fellows and is the largest training site in the state • These individuals bring a key influx of talent to Birmingham/the state of Alabama • Lisa Willett, M.D., MACM, FACP, has received a five-year, $1.8 million grant from the American Medical Association to study and reduce resident physician burnout, along with three other leading U.S. academic medical centers SCHOOL OF MEDICINE

Alice Goepfert, M.D. Associate Dean of GME

CAHABA MEDICAL CARE & FAMILY MEDICINE PARTNERSHIP 36

• UAB has formed a partnership with Cahaba Medical Care to launch the Family Medicine Residency program and address Alabama’s physician shortage

Irfan Asif, M.D. Chair Department of Family and Community Medicine

• Program will recruit 12 new graduates per year during the three-year residency • UAB maintains 40 other family medicine physician residents in the state, with current UAB residencies in Huntsville and Selma

SCHOOL OF MEDICINE

John Waits, M.D., FAAFP CEO Cahaba Medical Care

CLINICAL CARE 300 physicians named “Best Doctors in America”

ARRIVED APPOINTMENTS

SCHOOL OF MEDICINE

SURGICAL VOLUMES

Surgical Volumes 54,000 51,910

52,000 50,000

49,466

48,000 46,512 45,520

46,000 44,754 44,000 42,000 40,000

2015

2016

2017 Surgical Volumes

SCHOOL OF MEDICINE

2018

2019

Linear (Surgical Volumes)

STRATEGIC ALLIANCE WITH ASCENSION ST. VINCENT’S

• UAB and Ascension St. Vincent’s are entering a strategic alliance to improve care in the Birmingham metropolitan area and throughout Alabama • The alliance will utilize innovative strategies to address health disparities, mental and behavioral health, and diabetes, with an emphasis on expanded access for poor, vulnerable and rural populations • Through closer alignment of each organization’s many locations, specialties and expertise, the health systems will strive to better accommodate patients

SCHOOL OF MEDICINE

NEW OPENINGS • The UAB Proton Center acquired ‘Emma,’ the 90-ton cyclotron that is a key piece of technology for proton therapy used to treat many types of cancer

Proton Center

• Proton International at UAB opened Jan. 13, 2020, with first therapy treatments expected to take place by the end of February • Opened UAB Medicine Hoover Primary and Specialty Care clinic Hoover Clinic SCHOOL OF MEDICINE

CONTINUED GROWTH

• Medical West, an affiliate of the UAB Health System, will construct a 200-bed replacement hospital near by 2022 • The 1917 Clinic at UAB will relocate to Birmingham’s Lakeview district in late 2020 or early 2021

Medical West rendering

• Gardendale freestanding ER and medical building opened Jan. 15, 2019 Gardendale ER SCHOOL OF MEDICINE

VA MEDICAL CENTER

• The Birmingham VA recently named a new director, Stacy Vasquez, who continues to be an outstanding partner for UAB Medicine • The VA received Whole Health (WH) designation from the Veterans Health Administration’s Office of Patient Care and Cultural Transformation • Kidney transplantation has been re-established at the Birmingham VA

SCHOOL OF MEDICINE

PEDIATRIC HSF CLINICAL PRACTICE COMMITTEE

Mike Warren, J.D. CEO, Children’s of Alabama

Mitchell Cohen, M.D.

Mike Chen, M.D. Surgeon in Chief

Physician in Chief

Committee Chair

SCHOOL OF MEDICINE

MAKE AN IMPACT

THE GRAND CHALLENGE

• As part of UAB's strategic plan, the university announced call for ambitious and impressive proposals—The Grand Challenge • Out of 77 proposals, Dr. Mona Fouad’s “Healthy Alabama 2030: Live HealthSmart” was selected as the winner of a three-year $2.7 million award • Dr. Fouad and her 90+ person team plan to move the state's health rankings up from the bottom worst by 2030

SCHOOL OF MEDICINE

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE • >800 faculty panel participants from across the Partner Network

• Participants are 3-4x more likely to be extramurally funded

CCTS Project Panels 200 180 160 140 120 100 80 60 40 20 0

2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019

• >10% year-over-year growth in total clinical trial expenditures ($75M in FY 19)

SCHOOL OF MEDICINE

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE

• The CCTS Partner Network has driven >$32M in NIH research funding for the current year • The number of Consortium Grants jumped from 2 in 2013 to 12 in 2017 • The CCTS has assumed leadership of the National CTSA Consortium, resulting in 8 additional projects and $3M in additional NIH funding SCHOOL OF MEDICINE

CHRONIC DISEASE/HEALTH DISPARITIES SUPPLEMENTS • Monica Baskin, Ph.D. & Mike Birrer, M.D., Ph.D O’Neal Comprehensive Cancer Center $3,827,966 – Cancer Research • Mona Fouad, M.D., MPH Obesity and Health Disparities Research Center $1,053,156 – Obesity Research • Orlando Gutierrez, M.D., MMSc & Anupam Agarwal, M.D. O’Brien Center for Kidney Diseases $885,314 – Diabetes Research

SCHOOL OF MEDICINE

• Steve Rowe, M.D., MSPH & Mark Dransfield, M.D. UAB CF Research and Translation Core Center $884,599 – Chronic Lung Disease • Ken Saag, M.D., M.Sc. Center of Research Translation for Gout $961, 116 – Gout

TOTAL: $7,612,151

Anupam Agarwal, M.D. Executive Vice Dean

GLOBAL HEALTH – WHERE WE WORK

• Africa Health Research Institute – Durban, South Africa

• Universidad Peruana Cayetano Heredia – Lima, Peru

• Alexandria University Faculty of Medicine – Alexandria, Egypt

• University of Buea and the Cameroon Baptist Convention Health Services – Cameroon

• Centre for Infectious Disease Research – Lusaka, Zambia • Mbarara University of Science and Technology – Mbarara, Uganda • Pontifícia Universidade Católica de Paraná – Paraná, Brazil • Sefako Makgatho Health Science University – Pretoria, South Africa • Universidad de Antioquia – Medellín, Colombia SCHOOL OF MEDICINE

• University of Cape Town Faculty of Health Sciences – Cape Town, South Africa • University of Limpopo Faculty of Health Sciences – Sovenga, Limpopo, South Africa • University of the Witwatersrand Faculty of Health Sciences – Durban, South Africa • Walter Sisulu University Faculty of Health Sciences – Eastern Cape Province, South Africa © UAB. All Rights Reserved.

ADDRESSING THE OPIOID EPIDEMIC

• In 2017, Alabama had the highest opioid prescription rate in the country, nearly twice as high as the national average • The Department of Emergency Medicine launched the Medication Assisted Treatment to help patients with opioid use disorders get appropriate therapy and referral for further assistance (Image from AL.com)

SCHOOL OF MEDICINE

ADDRESSING THE OPIOID EPIDEMIC

• New UAB Opioid Stewardship Committee, chaired by Juhan Paiste, M.D. MBA, CPE, executive vice chair of the Department of Anesthesiology and Perioperative Medicine • Karen Cropsey, Psy.D., professor in the Department of Psychiatry and Behavioral Neurobiology, has been appointed to the Committee on the Review of Specific Programs in the Comprehensive Addiction and Recovery Act for the National Academies of Sciences, Engineering and Medicine

Dr. Paiste

• Cropsey has also submitted a proposal to establish the Center for Addiction and Pain Prevention and Intervention (CAPPI) Dr. Cropsey

SCHOOL OF MEDICINE

PROVIDE THE TOOLS

CORES ARE CRITICAL TO OUR FUTURE RESEARCH SUCCESS

• Vision: UAB will be a regional, national, and world leader in academic research infrastructure and environment making it the institution of choice for research scientists • Mission: The Institutional Research Cores Program will provide the most effective cutting-edge research infrastructure to the faculty of UAB • IRCP Oversight Committee is finalizing institutional model and business plan • UAB is significantly behind in capital equipment investment in cores • Process for identifying institutional cores will be implemented in 2020

SCHOOL OF MEDICINE

Michael Bertram, Ph.D. Director of Institutional Research Core Program

A COMMITMENT TO WELLNESS

• The Office of Wellness has moved into a new space (KCPD 509) to make wellness resources and programming more accessible • Well-Being Index has been launched to Faculty, APPs, Trainees, Medical Students, Nurses, and will be launched to all employees and staff in 2020 • Staff members include: David Rogers, M.D. MHPE; Katherine Meese, Ph.D, MPH; Sandra Frazier, M.D.; and Nisha Patel, MSHA, MBA SCHOOL OF MEDICINE

HEALTHCARE EDUCATORS ACADEMY

• Ensure that we’re supporting our instructors • Partnership between the Schools of Dentistry, Health Professions, Public Health, Nursing, and Medicine • Three pillars: Teaching Excellence, Career Advancement, Professional Meaning • Pilot cohort has 12 mentors and 12 mentees SCHOOL OF MEDICINE

INSTITUTE FOR LEADERSHIP

• UAB Medicine Leadership Development Office (LDO) recently launched the Institute for Leadership, a development program designed to enhance existing personal, managerial, and leadership capabilities • Program is an intentional investment to foster excellence in critical competencies and to promote the ongoing success of UAB Medicine • Pilot program launched in August of 2019 and concluded this past December

SCHOOL OF MEDICINE

SPACE

Three-phase project that will create space for ~32-40 new recruits.

Victor Darley-Usmar, Ph.D. Associate Dean, Research

SCHOOL OF MEDICINE

DIVERSITY AND INCLUSION

ADDRESS UNCONSCIOUS BIAS • The Office for Diversity and Inclusion has presented The Common Thread toolkit to every SOM department

Mona Fouad, M.D., MPH

• “My hope is that wide-scale adoption of the toolkit will help us continue to pursue our mission as a world-class academic medical center.” – Dr. Mona Fouad, Senior Associate Dean for Diversity and Inclusion

SCHOOL OF MEDICINE

CHAMPION DIVERSITY

• We celebrated our third annual Diversity Fair, an event that continues to grow each year –You’re invited to attend our 4th Diversity Fair Friday, Jan. 31 • Latesha Elopre, M.D., MSPH, was named director of Diversity and Inclusion for GME at the beginning of 2019 and was charged with leading efforts to improve GME diversity • The Office for Diversity and Inclusion created the Women in Medicine and Science Newsletter SCHOOL OF MEDICINE

CCTS PROMOTES DIVERSE RESEARCH WORKFORCE

• The CCTS is working to increase diversity through: • NRSA Training (TL1) and Mentored Career Development (KL2) Positions • Diversity Supplements • DRIVEN Program • UAB will host the 2020 national meeting for the Harold Amos Scholars Program • Dr. Latesha Elopre and Dr. Gregory Payne were recently named recipients SCHOOL OF MEDICINE

GENDER EQUITY COMPENSATION REVIEW

• Faculty CV data collection completed in December 2019 • Study to be completed by end of calendar year 2020 • Labor economist will be analyzing the data over the next several months • Be on the lookout for dates of town halls and email communications with updates about this process and avenues for questions

SCHOOL OF MEDICINE

UNDERSTAND EACH PATIENT

ALABAMA GENOMIC HEALTH INITIATIVE

• Enrollment: 5,500+ in all 67 Alabama counties • 77 actionable results returned representing genetic risks for disease including cardiovascular and cancer conditions • 92% consent to biobank and share data

Bruce Korf, M.D., Ph.D. Associate Dean Genomic Medicine

We are submitting a new protocol to the IRB that will pilot AGHI partnerships with a set of primary care clinics, where, in addition to the existing AGHI return of results, we will also be returning polygenic risk scores and pharmacogenetic data. SCHOOL OF MEDICINE

ALL OF US RESEARCH PROGRAM • The Southern Network of All of Us–led by UAB– has enrolled 19,200+ participants • Consistently #1 in daily recruitment • UAB investigators, funded by an additional $7 million funding award from NIH, will conduct a pilot study to discover better ways to engage and retain those enrollees

SCHOOL OF MEDICINE

Bruce Korf, M.D., Ph.D. Associate Dean Genomic Medicine

Mona Fouad, M.D., MPH Senior Associate Dean for Diversity and Inclusion

Beth Lewis, M.D., MSPH Chair, Department of Epidemiology School of Public Health

HUGH KAUL PRECISION MEDICINE INSTITUTE & UAB GENOMIC MEDICINE

• Nita Limdi, Pharm.D, Ph.D., MSPH, FAHA, is PI of a proposal for UAB to join the eMERGE network, which is an NHGRI funded consortium aimed at integration of genomic data and electronic health records • By joining the eMERGE network, the Hugh Kaul PMI will be part of the largest NIH-funded consortia on genomic medicine: All of Us, CSER (Clinical Sequencing Evidence-Generating Research Consortium), and eMERGE

Nita Limdi, Pharm.D, Ph.D., MSPH, FAHA

• Bruce Korf, M.D., Ph.D., is co-chairing a national meeting as part of the NGHRI Genomic Medicine Working Group to focus on Bruce Korf, M.D., Ph.D. population genomics

Assoc. Dean for Genomic Medicine

SCHOOL OF MEDICINE

HUGH KAUL PRECISION MEDICINE INSTITUTE

• Commenced 4-year, Phase 2 of Undiagnosed Diseases Network with award from NIH as joint operator of the Coordinating Center, with a responsibility for designing personalized therapeutics plans for diagnosed patients • Awarded Phase 2 of NIH NCATS Translator program to develop an AI-driven personalized drug repurposing tool • Awarded U54 joint with Mayo for a Research Network on Disorders of Glycosylation • Includes funding for a clinical trial of a novel therapeutic approach for Dr. Might’s son's disorder—NGLY1 deficiency—as well as a natural history study of patients with glycosylation disorders SCHOOL OF MEDICINE

Matt Might, Ph.D. Director of the Hugh Kaul PMI

SOURCES OF FUNDS

LaKisha Mack, MBA Associate Dean Administration and Finance

SCHOOL OF MEDICINE

SOURCES OF FUNDS

THE SCHOOL REMAINS FINANCIALLY PRUDENT AND IN THE BLACK

SCHOOL OF MEDICINE

AEF

AEF Total Contribution $70,000,000.00

$>57M

$60,000,000.00

$50,000,000.00 $22,727,485.00 $40,000,000.00 $12,979,679.00 $30,000,000.00

$12,202,749.00

$13,118,000.00

$420,271.00

$20,000,000.00 $34,653,651.00 $10,000,000.00

$21,491,756.00

$21,671,951.00

2015

2016

$26,933,487.00

2017 Budgeted

Variable

SCHOOL OF MEDICINE

$29,028,796.00

2018

2019

Dawn Bulgarella, MSHA, CPA Senior Associate Dean Administration and Finance

UPCOMING EVENTS

Francis Collins, M.D., Ph.D. Director, National Institutes of Health 8-9 a.m., March 6, 2020 Margaret Cameron Spain Auditorium

Dennis McKearin, Ph.D. Senior Scientific Officer, Howard Hughes Medical Institute 9-10 a.m., February 17, 2020 Finley Conference Room

SCHOOL OF MEDICINE

TIME FOR A TEST!

SCHOOL OF MEDICINE

QUESTIONS?

Join me at “Dreams of Hope: Birmingham's Historic 16th Street Baptist Church Welcomes Violins of Hope” on Feb. 6 at the Alabama Theatre